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https://www.readbyqxmd.com/read/27923102/pain-treatment-continues-to-be-inaccessible-for-many-patients-around-the-globe-second-phase-of-opioid-price-watch-a-cross-sectional-study-to-monitor-the-prices-of-opioids
#1
Tania Pastrana, Roberto Wenk, Lukas Radbruch, Ebtesam Ahmed, Liliana De Lima
BACKGROUND: Strong opioids are a cornerstone of pain treatment, of which morphine is considered an essential analgesic by the World Health Organization. Access to opioids is limited, due to restrictive laws, limited education, and high prices. This is the second phase of a global project to monitor and report the dispensing price of opioids with the specific aim to expand and increase the information and allow further analysis of the challenges in their availability and affordability...
December 6, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27922958/lipoma-in-the-face-associated-with-maxillofacial-trauma
#2
Fábio Roberto de Souza Batista, Jéssica Araújo Figueira, Rômulo Maciel Lustosa, João Matheus Scherbaum Eidt, Marcello Piacentini, Ângelo José Pavan
No abstract text is available yet for this article.
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27922817/ischemic-stroke-patients-are-biologically-older-than-their-chronological-age
#3
Carolina Soriano-Tárraga, Eva Giralt-Steinhauer, Marina Mola-Caminal, Rosa M Vivanco-Hidalgo, Angel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Sergi Sayols-Baixeras, Roberto Elosua, Jaume Roquer, Jordi Jiménez-Conde
Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls and 82 patients with ischemic stroke were paired by chronological age, ranging from 39 to 82 years...
August 25, 2016: Aging
https://www.readbyqxmd.com/read/27922552/novel-use-of-all-trans-retinoic-acid-in-a-model-of-lipopolysaccharide-immunosuppression-to-decrease-the-generation-of-myeloid-derived-suppressor-cells-by-reducing-the-proliferation-of-cd34-precursor-cells
#4
Daiana Martire-Greco, Nahuel Rodriguez-Rodrigues, Luis A Castillo, María Belén Vecchione, Marcelo de Campos-Nebel, Marlina Córdoba Moreno, Roberto Meiss, Mónica Vermeulen, Veronica I Landoni, Gabriela C Fernandez
All-trans-Retinoic Acid (ATRA) is a derivative of vitamin A with anti-proliferative properties. Endotoxin shock and subsequent immunosuppression (IS) by lipopolysaccharide (LPS) stimulates myelopoiesis with expansion of myeloid-derived suppressor cells (MDSC). Since we have previously shown that ATRA reverses the IS state by decreasing functional MDSC, our aim was to investigate if ATRA was able to modulate MDSC generation by regulating myelopoiesis in murine hematopoietic organs. We found that ATRA administration in vivo and in vitro decreased the number of CD34+ precursor cells that were increased in IS mice...
November 25, 2016: Shock
https://www.readbyqxmd.com/read/27922288/medial-gastrocnemius-myotendinous-junction-displacement-and-plantar-flexion-strength-in-patients-treated-with-immediate-rehabilitation-after-achilles-tendon-repair
#5
Carlos I De la Fuente, Roberto Peña Y Lillo, Rodrigo Ramirez Campillo, Pablo Ortega-Auriol, Mauricio Delgado, Joel Alvarez-Ruf, Gabriel Carreño
CONTEXT:  Pathologic plantar flexion frequently occurs after operative repair of the Achilles tendon (AT) because of immobilization and non-weight bearing in the first weeks of traditional rehabilitation. Novel rehabilitation strategies that apply mobilization and weight bearing have been proposed, but their effects on medial gastrocnemius myotendinous junction displacement (MJD) and isometric plantar-flexion strength (PFS) are unknown. OBJECTIVE:  To compare the effects of 12 weeks of immediate versus traditional rehabilitation on MJD and PFS in patients with percutaneous AT repair and to compare AT rupture scores (ATRSs) during follow-up...
December 6, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27920892/surface-modification-and-cellular-uptake-evaluation-of-au-coated-ni80fe20-nanodiscs-for-biomedical-applications
#6
Gabriele Barrera, Loredana Serpe, Federica Celegato, Marco Coїsson, Katia Martina, Roberto Canaparo, Paola Tiberto
A nanofabrication technique based on self-assembling of polystyrene nanospheres is used to obtain magnetic Ni80Fe20 nanoparticles with a disc shape. The free-standing nanodiscs (NDs) have diameter and thickness of about 630 nm and 30 nm, respectively. The versatility of fabrication technique allows one to cover the ND surface with a protective gold layer with a thickness of about 5 nm. Magnetization reversal has been studied by room-temperature hysteresis loop measurements in water-dispersed free-standing NDs...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920813/densitometric-evaluation-of-bone-prosthetic-counterface-in-hip-and-knee-arthroplasty-with-modern-implants
#7
Andrea Cozzi Lepri, Marco Giorgini, Carla Signorini, Christian Carulli, Roberto Civinini, Maria Luisa Brandi, Massimo Innocenti
INTRODUCTION: Recent acquisitions of the complex mechanisms of osseointegration between implants and host bone have gained attention, accordingly to the methods of evaluation of these interactions. DEXA analysis is considered an useful tool to assess such phenomena, in order to analyse in a quantitative manner the local metabolic activity of the bone, and to evaluate over the time the integration between host bone and prosthetic components. The purpose of the present study is to report about a preliminary experience in the analysis of osseointegration processes of patients undergoing a primary Total Hip Arthroplasty (THA) or a revision Total Knee Arthroplasty (rTKA)...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27920698/a-case-of-en-bloc-excision-of-a-chest-wall-leiomyosarcoma-and-closure-of-the-defect-with-non-cross-linked-collagen-matrix-egis-%C3%A2
#8
Marco Rastrelli, Saveria Tropea, Romina Spina, Alessandra Costa, Roberto Stramare, Simone Mocellin, Maria Giuseppina Bonavina, Carlo Riccardo Rossi
Sarcomas arising from the chest wall account for less than 20% of all soft tissue sarcomas, and at this site, primitive tumors are the most frequent to occur. Leiomyosarcoma is a malignant smooth muscle tumor and the best outcomes are achieved with wide surgical excision. Although advancements have been made in treatment protocols, leiomyosarcoma remains one of the more difficult soft tissue sarcoma to treat. Currently, general local control is obtained with surgical treatment with wide negative margins. We describe the case of a 50-year-old man who underwent a chest wall resection involving a wide portion of the pectoralis major and minor muscle, the serratus and part of the second, third and fourth ribs of the left side...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27920286/advanced-interatrial-block-and-ischemic-stroke-the-atherosclerosis-risk-in-communities-study
#9
Manuel Martinez-Selles, Adrian Baranchuk, Roberto Elosua, Antonio Bayés de Luna, Wesley T O'Neal, Hooman Kamel, Zhu-Ming Zhang, Lin Y Chen, Alvaro Alonso, Elsayed Z Soliman
No abstract text is available yet for this article.
December 6, 2016: Neurology
https://www.readbyqxmd.com/read/27919786/increasing-in-cysteine-proteinase-b-expression-and-enzymatic-activity-during-in-vitro-differentiation-of-leishmania-viannia-braziliensis-first-evidence-of-modulation-during-morphological-transition
#10
Cinthia Bernardes Gomes, Franklin Souza da Silva, Karen Dos Santos Charret, Bernardo Acácio Santini Pereira, Léa Cysne Finkelstein, Raquel Santos de Souza, Luzia Monteiro de Castro Côrtes, Mirian Claudia Souza Pereira, Francisco Odêncio Rodrigues de Oliveira, Carlos Roberto Alves
Leishmania (Viannia) braziliensis presents adaptive protease-dependent mechanisms, as cysteine proteinases B (CPB). This work focuses on the expression of three cpb gene isoforms and CPB enzymatic activity during the parasite differentiation. Relative expression levels of LbrM.08.0810 gene was assessed, showing a higher quantity of transcripts in the logarithmic promastigotes phase than in the stationary promastigotes phase (> 1.5 times). The cbp gene tends to decrease during acid pH shock and increases when the temperature rises (> 1...
December 2, 2016: Biochimie
https://www.readbyqxmd.com/read/27919528/laparoscopic-approach-to-the-treatment-of-type-ii-choledocal-cysts
#11
Aylhin López-Marcano, Roberto de la Plaza-Llamas, José Manuel Ramia, Farah Al-Shwely, Jhonny Gonzales-Aguilar, Anibal Medina Velasco
No abstract text is available yet for this article.
December 2, 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27919295/advances-in-intelligence-research-what-should-be-expected-in-the-xxi-century-questions-answers
#12
Roberto Colom
Here I briefly delineate my view about the main question of this International Seminar, namely, what should we expecting from the XXI Century regarding the advancements in intelligence research. This view can be summarized as 'The Brain Connection' (TBC), meaning that neuroscience will be of paramount relevance for increasing our current knowledge related to the key question: why are some people smarter than others? We need answers to the issue of what happens in our brains when the genotype and the environment are integrated...
December 6, 2016: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/27919259/functional-and-radiographic-outcomes-of-hallux-valgus-correction-by-mini-invasive-surgery-with-reverdin-isham-and-akin-percutaneous-osteotomies-a-longitudinal-prospective-study-with-a-48-month-follow-up
#13
Carlo Biz, Michele Fosser, Miki Dalmau-Pastor, Marco Corradin, Maria Grazia Rodà, Roberto Aldegheri, Pietro Ruggieri
BACKGROUND: Minimally invasive surgery (MIS) represents one of the most innovative surgical treatments of hallux valgus (HV). However, long-term outcomes still remain a matter of discussion within the orthopaedic community. The purpose of this longitudinal prospective study was to evaluate radiographic and functional outcomes in patients with mild-to-severe HV who underwent Reverdin-Isham and Akin percutaneous osteotomy, following exostosectomy and lateral release. METHODS: Eighty patients with mild-to-severe symptomatic HV were treated by MIS...
December 5, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27919244/surgical-antibiotic-prophylaxis-in-children-a-mixed-method-study-on-healthcare-professionals-attitudes
#14
Angela Giusti, Stefania Spila Alegiani, Marta Luisa Ciofi Degli Atti, Sofia Colaceci, Roberto Raschetti, Pasquale Arace, Raffaele Spiazzi, Massimiliano Raponi
BACKGROUND: Qualitative and quantitative research investigating determinants of adherence to clinical guidelines (GLs) on surgical antibiotic prophylaxis (SAP) are scarce. We conducted a mixed-method study aimed at investigating barriers and at describing attitudes of healthcare professionals (HCPs) regarding SAP in three Italian children's hospitals. METHODS: The study comprised two sequential phases: 1) collection of qualitative data through focus groups; 2) conduction of a survey on HCPs attitudes towards SAP...
December 5, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27919154/-many-doubts-about-the-relationship-between-cases-of-microcephaly-and-zika-virus-in-brazil
#15
Roberto Ronchetti, Pietro Massimiliano Bianco
During the last few years, Zika virus rapidly spread across Central and South America and in the last months has spread also across Southern States of USA. As the epidemic began in Brazil, an increase of microcephaly cases was registered, causing concern and inducing the World Health Organization to raise an alarm. Certainly, the Zika virus, as many other viruses, has the capacity to induce severe cerebral lesions in foetuses of women infected during the first months of pregnancy. Moreover, more than 80% of cases of craniostenosys that verisimilarly took place in Brazil from September 2015 up to now were registered in few states of North- Eastern Brazil, where peaks of this malformation were registered several years before the appearance of Zika virus...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27919148/-contribution-of-amenable-mortality-to-the-decrease-of-overall-mortality-in-piedmont-region-northern-italy-1980-2011
#16
Teresa Dalla Zuanna, Marco Dalmasso, Alberto Amidei, Roberto Gnavi
OBJECTIVES: to describe overall and amenable mortality trends over the last 30 years in the Local Health Authorities (LHAs) of Piedmont Region (Northern Italy). By comparing these trends, it is possible to analyse intraregional variability in the performance of the healthcare system. DESIGN: descriptive study. SETTING AND PARTICIPANTS: mortality data from the Italian National Institute of Statistics (Istat) for the population between 0 and 74 years resident in Piedmont Region for the period 1980-2011...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27918912/predicting-cyp2d6-phenotype-from-resting-brain-perfusion-images-by-gradient-boosting
#17
Giulio Napolitano, Julia C Stingl, Matthias Schmid, Roberto Viviani
The cytochrome P450 enzyme 2D6 is involved in the metabolism of 20% of all commonly used drugs, including many psychotropic drugs and CNS-active substances. CYP2D6 is among the CYP enzymes with the highest expression levels in the brain, suggesting a role in the local brain metabolism of psychotropic drugs and the existence of endogenous substrates. The genetic polymorphism of CYP2D6, which causes individual differences in activity levels of the enzyme, has also been characterized functionally in human brain imaging studies...
November 22, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27918064/cortical-excitability-in-patients-with-resistance-to-thyroid-hormone-compared-to-patients-with-hypothyroidism-and-euthyroid-controls-a-transcranial-magnetic-stimulation-study
#18
C Terranova, V Rizzo, A Calamuneri, L Bartolone, F Morgante, D Bruschetta, V Roberto, P Girlanda, S Benvenga, A Quartarone
Resistance to thyroid hormone (RTH) describes a rare syndrome in which serum levels of thyroid hormones are elevated but serum levels of thyroid stimulating hormone (TSH) are unsuppressed. The importance of thyroid hormones for the normal function of the adult brain is corroborated by the frequent association of thyroid dysfunctions with neurological and psychiatric symptoms. In this study we investigated whether adult thyroid hormone resistance affects cortical excitability and modulates inhibitory and excitatory intracortical circuitries by using transcranial magnetic stimulation...
January 1, 2016: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/27917678/traditional-mediterranean-plants-characterization-and-use-of-an-essential-oils-mixture-to-treat-malassezia-otitis-externa-in-atopic-dogs
#19
Simona Nardoni, Luisa Pistelli, Ilenia Baronti, Basma Najar, Francesca Pisseri, Rose Vanessa Bandeira Reidel, Roberto Papini, Stefania Perrucci, Francesca Mancianti
Several plants extracts from Mediterranean countries are traditionally employed in skin troubles both in humans and in animals. Malassezia pachydermatis is a lipophylic yeast responsible for otitis externa and dermatitis in dogs and for cutaneous and systemic disease in humans. Five mixtures of essential oils obtained from Mediterranean plants (Citrus paradisi, Salvia sclarea, Ocimum basilicum, Rosmarinus officinalis, Citrus limon, Anthemis nobilis, Lavandula hybrida and Thymus vulgaris) provided with antifungal and/or anti-inflammatory action assayed in vitro, were tested in vivo versus M...
December 5, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27917642/can-nanotechnology-improve-cancer-diagnosis-through-mirna-detection
#20
Roberto Fiammengo
miRNAs are key regulators of gene expression, and alterations in their expression levels correlate with the onset and progression of cancer. Although miRNAs have been proposed as biomarkers for cancer diagnosis, their application in routine clinical praxis is yet to come. Current quantification strategies have limitation, and there is a great interest in developing innovative ones. Since a few years, nanotechnology-based approaches for miRNA quantification are emerging at fast pace but there is urgent need to go beyond the proof-of-concept stage...
December 5, 2016: Biomarkers in Medicine
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