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https://www.readbyqxmd.com/read/29908422/bioprospection-of-immature-salivary-glands-of-chrysomya-megacephala-fabricius-1794-diptera-calliphoridae
#1
Ronaldo Roberto Tait Caleffe, Stefany Rodrigues de Oliveira, Adriana Aparecida Sinópolis Gigliolli, Maria Claudia Colla Ruvolo-Takasusuki, Helio Conte
Larval therapy (LT) comprises the application of sterile Calliphoridae larvae for wound debridement, disinfection, and healing in humans and animals. Larval digestion plays a key role in LT, where the salivary glands and gut produce and secrete proteolytic and antimicrobial substances. The objective of this work was to bioprospect the salivary glands of Chrysomya megacephala (Fabricius, 1794) larvae, using ultrastructural, morphological, and histological observations, and the total protein electrophoretic profile...
June 8, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29908394/system-on-chip-design-of-the-cortical-diencephalic-centre-of-the-lower-urinary-tract
#2
Francisco Maciá Pérez, Leandro Zambrano Méndez, José Vicente Berná Martínez, Roberto Sepúlveda Lima
This article presents the design of a field programmable gate array (FPGA)-based prototype of a system on chip (SoC) capable of behaving as one of the nerve centres comprising the neuroregulatory system in humans: the cortical-diencephalic nerve centre. The neuroregulatory system is a complex nerve system consisting of a heterogeneous group of nerve centres. These centres are distributed throughout the length of the spinal cord, are autonomous, communicate via interneurons, and govern and regulate the behaviour of multiple organs and systems in the human body...
June 13, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29908224/implication-of-surgical-procedure-in-the-induction-of-headache-and-generalized-painful-sensation-in-a-fluid-percussion-injury-model-in-rats
#3
Fernando da SilvaFiorin, Caroline Cunha do Espírito Santo, Adair Roberto Soares Santos, Michele Rechia Fighera, Luiz Fernando Freire Royes
BACKGROUND: This study demonstrated the effects of traumatic brain injury (TBI) and each step of the surgical procedure for a fluid percussion injury (FPI) model on periorbital allodynia. NEW METHOD: Adult male Wistar rats were divided in naive, incision, scraping, sham-TBI and TBI groups. Periorbital allodynia was evaluated using von Frey filaments, and heat hyperalgesia of the hindpaws was evaluated by a Plantar Test Apparatus. RESULTS: The statistical analyses revealed that the surgical procedure decreased von Frey filaments thresholds twenty-four hours after the surgery in all groups when compared to the naive group (p < 0...
June 13, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29908032/prevalence-and-antifungal-susceptibility-of-candida-species-among-pregnant-women-attending-a-school-maternity-at-natal-brazil
#4
Laíse Diana Dos Santos Brandão, Douglas Boniek, Maria Aparecida de Resende Stoianoff, Flávia Maria Rezende da Mata, Paulo Roberto Medeiros de Azevedo, José Veríssimo Fernandes, Vânia Sousa Andrade
Vulvovaginal candidiasis (VVC) is an inflammatory disease of the vulva and vagina caused by different yeasts of the genus Candida which is responsible for infection in pregnant patients who attended Maternidade Escola Januário Cicco, Rio Grande do Norte, Brazil. From 41 samples, 19 yeasts were identified phenotypically as Candida albicans, and one as C. glabrata which is reported as the non-albicans species most frequently isolated from vulvovaginitis. The susceptibility to selected antifungal agents (fluocytosine, fluconazole, voriconazole, amphotericin B, caspofungin and micafungin) was determined, and the association between patient related signs and symptoms aided the construction of an epidemiological profile...
June 16, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29907947/introduction-of-direct-oral-anticoagulant-within-7-days-of-stroke-onset-a-nomogram-to-predict-the-probability-of-3-month-modified-rankin-scale-score-2
#5
Manuel Cappellari, Gianni Turcato, Stefano Forlivesi, Nicola Micheletti, Giampaolo Tomelleri, Bruno Bonetti, Giovanni Merlino, Roberto Eleopra, Monia Russo, Roberto L'Erario, Alessandro Adami, Carolina Gentile, Anna Gaudenzi, Sandro Bruno, Paolo Bovi
In clinical practice, direct oral anticoagulants (DOACs) are often started earlier (≤ 7 days) than in randomized clinical trials after stroke. We aimed to develop a nomogram model incorporating time of DOAC introduction ≤ 7 days of stroke onset in combination with different degrees of stroke radiological/neurological severity at the time of treatment to predict the probability of unfavorable outcome. We conducted a multicenter prospective study including 344 patients who started DOAC 1-7 days after atrial fibrillation-related stroke onset...
June 15, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29907935/circulating-mir-215-5p-and-mir-642a-5p-as-potential-biomarker-for-diagnosis-of-osteosarcoma-in-mexican-population
#6
Lucero Monterde-Cruz, Eric G Ramírez-Salazar, Genaro Rico-Martínez, Luis M Linares-González, Roberto Guzmán-González, Ernesto Delgado-Cedillo, Eréndira Estrada-Villaseñor, Margarita Valdés-Flores, Rafael Velázquez-Cruz, Alberto Hidalgo-Bravo
Osteosarcoma is the most common malignant bone neoplasia affecting individuals in the second decade of life. The survival rate has not been improved during the last 25 years, in part because of the lack of specific markers. The microRNAs have been identified as important regulators of gene expression, experimental evidence suggests these molecules as key players in cancer development and progression. To identify miRNAs differentially expressed in serum from patients with osteosarcoma compared to healthy donors in Mexican population...
June 15, 2018: Human Cell
https://www.readbyqxmd.com/read/29907882/relevance-of-placental-type-i-interferon-beta-regulation-for-pregnancy-success
#7
Ja-Young Kwon, Paulomi Aldo, Yuan You, Jiahui Ding, Karen Racicot, Xiaoyan Dong, John Murphy, Guy Glukshtad, Michelle Silasi, Jian Peng, Li Wen, Vikki M Abrahams, Roberto Romero, Gil Mor
Pregnancy is a unique immunologic and microbial condition that requires an adequate level of awareness to provide a fast and protective response against pathogens as well as to maintain a state of tolerance to paternal antigens. Dysregulation of inflammatory pathways in the placenta triggered by pathogens is one of the main factors responsible for pregnancy complications. Type I IFNs are key molecules modulating immune responses at the level of the placenta and are crucial for protection of the pregnancy via their antiviral and immune modulatory properties...
June 15, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29907698/selective-activation-of-retinoic-acid-%C3%AE-2-receptors-exerts-cardioprotective-effects
#8
Alice Marino, Takuya Sakamoto, Xiao-Han Tang, Lorraine J Gudas, Roberto Levi
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor (RARβ2), decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with myocardial ischemia and oxidative stress, we have now investigated the effects of AC261066 in an ex-vivo ischemia/reperfusion (I/R) injury model in hearts of two prototypic dysmetabolic mice. We found that a 6-week oral treatment with AC261066 in both genetically hypercholesterolemic (ApoE-/-) and obese (HFD-fed) wild-type mice exerts protective effects when their hearts are subsequently subjected to I/R ex vivo in the absence of added drug...
June 15, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29907654/nadph-oxidase-5-is-a-pro-contractile-nox-isoform-and-a-point-of-cross-talk-for-calcium-and-redox-signaling-implications-in-vascular-function
#9
Augusto C Montezano, Livia De Lucca Camargo, Patrik Persson, Francisco J Rios, Adam P Harvey, Aikaterini Anagnostopoulou, Roberto Palacios, Ana Caroline P Gandara, Rheure Alves-Lopes, Karla B Neves, Maria Dulak-Lis, Chet E Holterman, Pedro Lagerblad de Oliveira, Delyth Graham, Christopher Kennedy, Rhian M Touyz
BACKGROUND: NADPH Oxidase 5 (Nox5) is a calcium-sensitive superoxide-generating Nox. It is present in lower forms and higher mammals, but not in rodents. Nox5 is expressed in vascular cells, but the functional significance remains elusive. Given that contraction is controlled by calcium and reactive oxygen species, both associated with Nox5, we questioned the role of Nox5 in pro-contractile signaling and vascular function. METHODS AND RESULTS: Transgenic mice expressing human Nox5 in a vascular smooth muscle cell-specific manner (Nox5 mice) and Rhodnius prolixus , an arthropod model that expresses Nox5 endogenoulsy, were studied...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907443/apoa-1milano-muteins-orally-delivered-via-genetically-modified-rice-show-anti-atherogenic-and-anti-inflammatory-properties-in-vitro-and-in-apoe-atherosclerotic-mice
#10
Gabriele Romano, Serena Reggi, Barbara Kutryb-Zajac, Amanda Facoetti, Elisa Chisci, Mariateresa Pettinato, Maria Rita Giuffrè, Federica Vecchio, Silvia Leoni, Marco De Giorgi, Federica Avezza, Massimiliano Cadamuro, Luca Crippa, Biagio Eugenio Leone, Marialuisa Lavitrano, Ilaria Rivolta, Donatella Barisani, Ryszard Tomasz Smolenski, Roberto Giovannoni
BACKGROUND: Atherosclerosis is a slowly progressing, chronic multifactorial disease characterized by the accumulation of lipids, inflammatory cells, and fibrous tissue that drives to the formation of asymmetric focal thickenings in the tunica intima of large and mid-sized arteries. Despite the high therapeutic potential of ApoA-1 proteins, the purification and delivery into the disordered organisms of these drugs is still limited by low efficiency in these processes. METHODS AND RESULTS: We report here a novel production and delivery system of anti-atherogenic APOA-1Milano muteins (APOA-1M) by means of genetically modified rice plants...
June 11, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29907425/repurposing-steroidogenesis-inhibitors-for-the-therapy-of-neuropsychiatric-disorders-promises-and-caveats
#11
REVIEW
Roberto Frau, Marco Bortolato
Steroids exert a profound influence on behavioral reactivity, by modulating the functions of most neurotransmitters and shaping the impact of stress and sex-related variables on neural processes. This background - as well as the observation that most neuroactive steroids (including sex hormones, glucocorticoids and neurosteroids) are synthetized and metabolized by overlapping enzymatic machineries - points to steroidogenic pathways as a powerful source of targets for neuropsychiatric disorders. Inhibitors of steroidogenic enzymes have been developed and approved for a broad range of genitourinary and endocrine dysfunctions, opening to new opportunities to repurpose these drugs for the treatment of mental problems...
May 11, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29907373/effect-of-trochleocapitellar-index-on-adult-patient-reported-outcomes-after-noncomminuted-intra-articular-distal-humeral-fractures
#12
Giuseppe Rollo, Roberto Rotini, Denise Eygendaal, Paolo Pichierri, Michele Bisaccia, Ante Prkic, Alessandro Stasi, Luigi Meccariello
BACKGROUND: Anatomic surgical reduction of intra-articular fractures of the distal humerus is important to achieve the best long-term outcomes and prevent post-traumatic arthritis. In this study we compared the radiographic reduction using the trochleocapitellar index. We also correlated the trochleocapitellar index to the functional outcomes next to the comparison of the triceps brachii lifting approach and olecranon osteotomy approach, 2 common approaches for distal humeral fractures...
July 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29907219/effects-of-a%C3%A3-a%C3%A3-and-cilostazol-on-skin-microcirculation-and-viability-of-tram-flaps-in-hamsters
#13
Denise S Coelho da Mota, Fernando L Sicuro, Angela C Resende, Roberto S De Moura, Daniel A Bottino, Eliete Bouskela
BACKGROUND: Tissue necrosis caused by insufficient perfusion is a major complication in flap transfer. This study evaluated whether treatment with cilostazol or hydroalcoholic extract of seeds of Euterpe oleracea Mart. (açaí) protects the transverse rectus abdominis myocutaneous (TRAM) flap against ischemic damage in hamsters. MATERIALS AND METHODS: Fifty-four hamsters were divided into three oral treatment groups: placebo, açaí, or cilostazol. Caudally based, unipedicled TRAM flaps were raised, sutured back, classified into four vascular zones (I-IV), and evaluated for tissue viability, capillary blood flow (CBF), perfused vessel density (PVD), and microvascular flow index (MFI) by orthogonal polarization spectral imaging at three time points: immediately postoperatively (IPO), 24 h postoperatively (24hPO), and 7 d postoperatively (7POD)...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906924/exploring-the-diluted-ferromagnetic-p-spin-model-with-a-cavity-master-equation
#14
Erik Aurell, Eduardo Domínguez, David Machado, Roberto Mulet
We introduce an alternative solution to Glauber multispin dynamics on random graphs. The solution is based on the recently introduced cavity master equation (CME), a time-closure turning the, in principle, exact dynamic cavity method into a practical method of analysis and of fast simulation. Running CME once is of comparable computational complexity as one Monte Carlo run on the same problem. We show that CME correctly models the ferromagnetic p-spin Glauber dynamics from high temperatures down to and below the spinoidal transition...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906696/ictal-signs-in-tuberous-sclerosis-complex-clinical-and-video-eeg-features-in-a-large-series-of-recorded-seizures
#15
Miriam Nella Savini, Alessia Mingarelli, Aglaia Vignoli, Francesca La Briola, Valentina Chiesa, Angela Peron, Roberto Mai, Laura Tassi, Massimo Mastrangelo, Elena Zambrelli, Katherine Turner, Maria Paola Canevini
Epilepsy is the most common neurological symptom in tuberous sclerosis complex (TSC), occurring in 72-85% of affected individuals. Despite the large number of patients reported, their electroclinical phenotype has been rarely described. We analyzed seizure semiology through ictal video-electroencephalography (V-EEG) recordings in a large series of patients. In this multicenter study, we reviewed V-EEGs of 51 patients: ictal recordings were analyzed in correlation with their clinical variables. The median age of epilepsy onset was six months (one day-16 years), with onset in the first year of life in 71% patients (36/51), in 10 of them during the neonatal period...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29906651/quantifying-facial-expression-signal-and-intensity-use-during-development
#16
Helen Rodger, Junpeng Lao, Roberto Caldara
Behavioral studies investigating facial expression recognition during development have applied various methods to establish by which age emotional expressions can be recognized. Most commonly, these methods employ static images of expressions at their highest intensity (apex) or morphed expressions of different intensities, but they have not previously been compared. Our aim was to (a) quantify the intensity and signal use for recognition of six emotional expressions from early childhood to adulthood and (b) compare both measures and assess their functional relationship to better understand the use of different measures across development...
June 12, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29906576/papillary-tumor-of-the-pineal-region-in-children-presentation-of-a-case-and-comprehensive-literature-review
#17
REVIEW
Joham Choque-Velasquez, Roberto Colasanti, Julio Resendiz-Nieves, Behnam Rezai Jahromi, Olli Tynninen, Juhani Collan, Mika Niemelä, Juha Hernesniemi
The papillary tumor of the pineal region (PTPR) is a rare grade II-III pineal lesion with peculiar histologic and immunohistochemical features. These tumors mostly occur in adults, rarely in children (19 cases reported up to now). We present a 3-year-old boy who was re-operated for a recurrent PTPR (grade II). The gross total resection of the lesion, through an occipital interhemispheric approach in sitting position, was followed by adjuvant radiochemotherapy. Histological examination revealed tumor progression (grade III), and the MIB-1 proliferation index was higher than 25%...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29906416/bioactive-lipid-species-and-metabolic-pathways-in-progression-and-resolution-of-non-alcoholic-steatohepatitis
#18
REVIEW
Giovanni Musso, Maurizio Cassader, Elena Paschetta, Roberto Gambino
The prevalence of non-alcoholic steatohepatitis (NASH) is increasing worldwide, yet there are no effective treatments. A decade has passed since initial lipidomic analyses of liver tissues from patients with non-alcoholic fatty liver disease. We have learned that liver cells from patients with NASH have an abnormal lipid composition, and the accumulation of lipids leads to organelle dysfunction, cell injury and death, and chronic inflammation, called liptoxicity. We review the lipid species and metabolic pathways that contribute to pathogenesis of NASH, as well as potential therapeutic targets, including enzymes involved in fatty acid and triglyceride synthesis, bioactive sphingolipids and polyunsaturated-derived eicosanoids and specialized proresolving lipid mediators...
June 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29906303/combination-of-sugar-and-stable-isotopes-analyses-to-detect-the-use-of-non-grape-sugars-in-balsamic-vinegar-must
#19
Perini Matteo, Nardin Tiziana, Camin Federica, Malacarne Mario, Larcher Roberto
'Aceto Balsamico di Modena' (ABM) is a PGI (Protected Geographical Indication) salad dressing obtained from cooked and/or concentrated grape must, with the addition of wine vinegar and a maximum of 2% caramel (EU Reg. 583/2009). In this study we investigated whether the combination of 13 C/12 C of ethanol using Isotope Ratio Mass Spectrometry with 2 H-site-specific Natural Isotope Fractionation - Nuclear Magnetic Resonance, and minor sugars using Ion Chromatography with Pulse Amperometric and Charged Aerosol Detection, is able to improve detection of sugar addition to ABM must...
June 15, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29906154/convective-excitation-of-inertial-modes-in-binary-neutron-star-mergers
#20
Roberto De Pietri, Alessandra Feo, José A Font, Frank Löffler, Francesco Maione, Michele Pasquali, Nikolaos Stergioulas
We present the first very long-term simulations (extending up to ∼140  ms after merger) of binary neutron star mergers with piecewise polytropic equations of state and in full general relativity. Our simulations reveal that, at a time of 30-50 ms after merger, parts of the star become convectively unstable, which triggers the excitation of inertial modes. The excited inertial modes are sustained up to several tens of milliseconds and are potentially observable by the planned third-generation gravitational-wave detectors at frequencies of a few kilohertz...
June 1, 2018: Physical Review Letters
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