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https://www.readbyqxmd.com/read/28915719/genomic-analysis-of-exceptional-responder-to-regorafenib-in-treatment-refractory-metastatic-rectal-cancer-a-case-report-and-review-of-the-literature
#1
Krittiya Korphaisarn, Jonathan M Loree, Van Nguyen, Ryanne Coulson, Vijaykumar Holla, Beate C Litzenburger, Ken Chen, Gordon B Mills, Dipen M Maru, Funda Meric-Bernstan, Kenna R Mills Shaw, Scott Kopetz
We present the case of a 53-year-old male with metastatic rectal cancer who was treatment resistant to FOLFOX and FOLFOXIRI. Due to a Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation, regorafenib was given in the third line setting. Surprisingly, the patient had a prolonged partial response that lasted 27 months. Mutational status was extensively evaluated to identify potential alterations that might play a role as predictive markers for this unusual event. A poorly characterized but nontransforming mutation in Fms-like tyrosine kinase 4 (FLT4) was present in the tumor...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914087/effect-of-myofascial-techniques-for-treatment-of-persistent-arm-pain-after-breast-cancer-treatment-randomized-controlled-trial
#2
An De Groef, Marijke Van Kampen, Nele Vervloesem, Evi Dieltjens, Marie-Rose Christiaens, Patrick Neven, Lore Vos, Tessa De Vrieze, Inge Geraerts, Nele Devoogdt
OBJECTIVE: To investigate the effect of myofascial therapy in addition to a standard physical therapy program for treatment of persistent arm pain after finishing breast cancer treatment. DESIGN: Double-blinded (patient and assessor) randomized controlled trial. SETTING: University Hospitals Leuven, Belgium. PATIENTS: A total of 50 patients with persistent arm pain and myofascial dysfunctions after breast cancer treatment...
September 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28893864/the-beach-protein-lrba-is-required-for-hair-bundle-maintenance-in-cochlear-hair-cells-and-for-hearing
#3
Christian Vogl, Tanvi Butola, Natja Haag, Torben J Hausrat, Michael G Leitner, Michel Moutschen, Philippe P Lefèbvre, Carsten Speckmann, Lillian Garrett, Lore Becker, Helmut Fuchs, Martin Hrabe de Angelis, Sandor Nietzsche, Michael M Kessels, Dominik Oliver, Matthias Kneussel, Manfred W Kilimann, Nicola Strenzke
Lipopolysaccharide-responsive beige-like anchor protein (LRBA) belongs to the enigmatic class of BEACH domain-containing proteins, which have been attributed various cellular functions, typically involving intracellular protein and membrane transport processes. Here, we show that LRBA deficiency in mice leads to progressive sensorineural hearing loss. In LRBA knockout mice, inner and outer hair cell stereociliary bundles initially develop normally, but then partially degenerate during the second postnatal week...
September 11, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28859082/mouth-clicks-used-by-blind-expert-human-echolocators-signal-description-and-model-based-signal-synthesis
#4
Lore Thaler, Galen M Reich, Xinyu Zhang, Dinghe Wang, Graeme E Smith, Zeng Tao, Raja Syamsul Azmir Bin Raja Abdullah, Mikhail Cherniakov, Christopher J Baker, Daniel Kish, Michail Antoniou
Echolocation is the ability to use sound-echoes to infer spatial information about the environment. Some blind people have developed extraordinary proficiency in echolocation using mouth-clicks. The first step of human biosonar is the transmission (mouth click) and subsequent reception of the resultant sound through the ear. Existing head-related transfer function (HRTF) data bases provide descriptions of reception of the resultant sound. For the current report, we collected a large database of click emissions with three blind people expertly trained in echolocation, which allowed us to perform unprecedented analyses...
August 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28858190/performance-on-balance-evaluation-systems-test-bestest-impacts-health-related-quality-of-life-in-adult-spinal-deformity-patients
#5
Lieven Moke, Pieter Severijns, Sebastiaan Schelfaut, Kristel Van de Loock, Lore Hermans, Guy Molenaers, Ilse Jonkers, Lennart Scheys
STUDY DESIGN: Prospective single-center study OBJECTIVE.: Study investigates how dynamic balance performance complements 2D static radiographic measurements and demographics in terms of understanding health-related quality of life in Adult Spinal Deformity (ASD) patients. SUMMARY OF BACKGROUND DATA: Recent insights suggest that demographic variables have a stronger impact on health-related quality of life than 2D radiographic spinopelvic parameters in ASD patients METHODS...
August 23, 2017: Spine
https://www.readbyqxmd.com/read/28843145/presence-of-salmonella-and-escherichia-coli-o157-on-the-hide-and-presence-of-salmonella-escherichia-coli-o157-and-campylobacter-in-feces-from-small-ruminant-goat-and-lamb-samples-collected-in-the-united-states-bahamas-and-mexico
#6
Keelyn E Hanlon, Mark F Miller, Lacey M Guillen, Alejandro Echeverry, Erin Dormedy, Brittney Cemo, Loree A Branham, Shanequa Sanders, Mindy M Brashears
The objective of this study was to evaluate the frequency of Salmonella and E. coli O157 found on the hides, as well as presence of Salmonella, Campylobacter and E. coli O157 found in small-ruminant fecal samples from abattoirs and farms in California, New Mexico, Texas, Mexico and the Bahamas. In small-ruminant fecal samples, overall organism presence was identified as 13.9% Salmonella (n=532), 15.3% E. coli O157 (n=477) and 80.7% Campylobacter (n=176). Overall, on small-ruminant hide surfaces, Salmonella frequency was 17...
August 8, 2017: Meat Science
https://www.readbyqxmd.com/read/28836473/use-of-art-making-intervention-for-pain-and-quality-of-life-among-cancer-patients-a-systematic-review
#7
Kyung Soo Kim, Sarah Loring, Kristine Kwekkeboom
BACKGROUND: Although pain is one of the most prevalent symptoms among cancer patients, medications do not always result in sufficient pain relief. Furthermore, these medications only address the physical component of pain. Art making, a holistic approach, may distract the user's attention from pain and allow expression of the nonphysical (e.g., psychological, spiritual) components of pain. The purpose of this systematic review was to evaluate evidence for the efficacy of art-making interventions in reducing pain and improving health-related quality of life (QoL) among cancer patients...
August 1, 2017: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/28831722/reduced-motor-competence-in-children-with-obesity-is-associated-with-structural-differences-in-the-cerebellar-peduncles
#8
Mireille J C M Augustijn, Frederik J A Deconinck, Eva D'Hondt, Lore Van Acker, Ann De Guchtenaere, Matthieu Lenoir, Karen Caeyenberghs
Previous studies have suggested that neurological factors partly explain the reduced motor competence found in many children with obesity. Accordingly, the aim of this study was to compare motor competence and white matter organization of important pathways for motor control (cerebellar peduncles) in children with and without obesity. Nineteen children with obesity and 25 children with a healthy weight, aged 7-11 years old, were included. Anthropometric measurements were taken and the level of motor competence was assessed using the Movement Assessment Battery for Children (2nd Edition)...
August 22, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28826283/radiotherapy-and-hyperthermia-with-curative-intent-in-recurrent-high-risk-soft-tissue-sarcomas
#9
Franziska Eckert, Lore Helene Braun, Frank Traub, Hans-Georg Kopp, Bence Sipos, Ulf Lamprecht, Arndt-Christian Müller, Frank Paulsen, Daniel Zips
PURPOSE: Radiotherapy before or after resection is one of the pillars of treatment for localised high risk soft tissue sarcomas. Treatment intensification has been described with concurrent chemotherapy and hyperthermia. The aim of this study is to assess local control after multimodal treatment, focussing on the treatment of local recurrences after surgery only. PATIENTS AND METHODS: Of 42 patients treated in a prospective protocol with radiotherapy and hyperthermia, nine were treated for isolated local recurrences without metastatic spread...
August 21, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28818080/standardized-systemic-phenotypic-analysis-reveals-kidney-dysfunction-as-main-alteration-of-kctd1-i27n-mutant-mice
#10
Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth, Frauke Neff, Jan Rozman, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe de Angelis, Eckhard Wolf, Bernhard Aigner
BACKGROUND: Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further analyzed. METHODS: Analysis of the causative mutation as well as the standardized, systemic phenotypic analysis of the mutant line was carried out...
August 17, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28816636/the-distress-thermometer-predicts-subjective-but-not-objective-cognitive-complaints-six-months-after-treatment-initiation-in-cancer-patients-receiving-a-curative-cancer-treatment
#11
Michelle Lycke, Tessa Lefebvre, Lies Pottel, Hans Pottel, Lore Ketelaars, Karin Stellamans, Koen Van Eygen, Philippe Vergauwe, Patrick Werbrouck, Laurence Goethals, Patricia Schofield, Tom Boterberg, Philip R Debruyne
OBJECTIVES: Research has indicated that cancer-related cognitive impairments (CRCI) may be influenced by psychosocial factors such as distress, worry and fatigue. Therefore, we aimed to validate the distress thermometer (DT) as a screening tool to detect CRCI six months post treatment initiation in a group of general cancer patients. METHODS: Patients(18 years, n 125) with a histologically confirmed diagnosis of a solid cancer or haematological malignancy, scheduled for a curative treatment, were evaluated at baseline (T0) and six months post-treatment initiation (T1) for CRCI by a neuropsychological assessment including patient-reported outcome measures (PROMs)...
August 17, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28811052/current-and-future-perspectives-on-the-evaluation-prevention-and-conservative-management-of-breast-cancer-related-lymphoedema-a-best-practice-guideline
#12
EDITORIAL
Nick Gebruers, Hanne Verbelen, Tessa De Vrieze, Lore Vos, Nele Devoogdt, Lore Fias, Wiebren Tjalma
No abstract text is available yet for this article.
August 4, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28808027/de-novo-mutations-in-inhibitors-of-wnt-bmp-and-ras-erk-signaling-pathways-in-non-syndromic-midline-craniosynostosis
#13
Andrew T Timberlake, Charuta G Furey, Jungmin Choi, Carol Nelson-Williams, Erin Loring, Amy Galm, Kristopher T Kahle, Derek M Steinbacher, Dawid Larysz, John A Persing, Richard P Lifton
Non-syndromic craniosynostosis (NSC) is a frequent congenital malformation in which one or more cranial sutures fuse prematurely. Mutations causing rare syndromic craniosynostoses in humans and engineered mouse models commonly increase signaling of the Wnt, bone morphogenetic protein (BMP), or Ras/ERK pathways, converging on shared nuclear targets that promote bone formation. In contrast, the genetics of NSC is largely unexplored. More than 95% of NSC is sporadic, suggesting a role for de novo mutations. Exome sequencing of 291 parent-offspring trios with midline NSC revealed 15 probands with heterozygous damaging de novo mutations in 12 negative regulators of Wnt, BMP, and Ras/ERK signaling (10...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807640/rogue-nuns-grow-services-to-combat-growing-problems
#14
Loring Leifer
This paper tells the story of how an experiment in caring for the children of poor, working mothers became a multimillion-dollar early learning center. It follows the evolution of two nuns who began providing day care in a church and came to realize that children living in poverty need a much greater range of services. It covers how the sisters broke with the Catholic Church and engaged alternative and unorthodox sources to help the operation survive and to extend its reach. It documents how far the sisters went to keep the doors open and how they sustained success...
August 11, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28802725/body-mass-estimation-in-hominoids-age-and-locomotor-effects
#15
M Loring Burgess, Shannon C McFarlin, Antoine Mudakikwa, Michael R Cranfield, Christopher B Ruff
While there are a number of methods available for estimation of body mass in adult nonhuman primates, very few are available for juveniles, despite the potential utility of such estimations in both analyses of fossils and in museum collection based research. Furthermore, because of possible scaling differences, adult based body mass estimation equations may not be appropriate for non-adults. In this study, we present new body mass estimation equations for both adult and immature nonhuman hominoids based on joint and metaphyseal dimensions...
August 9, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28794806/recent-developments-in-the-treatment-of-metastatic-colorectal-cancer
#16
REVIEW
Jonathan M Loree, Scott Kopetz
Over the past decade there have been significant advances in the molecular characterization of colorectal cancer (CRC) that are driving treatment decisions. Expanded RAS testing beyond KRAS exon 2 was established as crucial for identifying patients who will respond to anti-epidermal growth factor receptor (EGFR) therapies and low-frequency mutations in RAS/tumor heterogeneity are gaining recognition as potential mechanisms of resistance. Despite this progress, the fact that we do not understand why left-sided but not right-sided tumors have improved outcomes following anti-EGFR therapy highlights our superficial understanding of this disease...
August 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/28792647/ultra-short-bowel-is-an-independent-risk-factor-for-liver-fibrosis-in-adults-with-home-parenteral-nutrition
#17
Dominique Cazals-Hatem, Lore Billiauws, Pierre-Emmanuel Rautou, Vanessa Bondjemah, Nicolas Poté, Olivier Corcos, Valérie Paradis, Francisca Joly
BACKGROUND & AIMS: Intestinal failure-associated liver disease is rare in adults and risk factors are unclear. The aim of this study was to determine risk factors of liver fibrosis in adults receiving home parenteral nutrition for intestinal failure and its impact on survival. METHODS: We retrospectively analysed patients with irreversible intestinal failure who underwent a liver biopsy between 2000 and 2013. Significant liver fibrosis was defined as ≥F2 according to NASH-CRN score...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28767562/deleterious-effect-of-ras-and-evolutionary-high-risk-tp53-double-mutation-in-colorectal-liver-metastases
#18
Yun Shin Chun, Guillaume Passot, Suguru Yamashita, Maliha Nusrat, Panagiotis Katsonis, Jonathan M Loree, Claudius Conrad, Ching-Wei D Tzeng, Lianchun Xiao, Thomas A Aloia, Cathy Eng, Scott E Kopetz, Olivier Lichtarge, Jean-Nicolas Vauthey
OBJECTIVE: To assess the impact of somatic gene mutations on survival among patients undergoing resection of colorectal liver metastases (CLM). BACKGROUND: Patients undergoing CLM resection have heterogeneous outcomes, and accurate risk stratification is necessary to optimize patient selection for surgery. METHODS: Next-generation sequencing of 50 cancer-related genes was performed from primary tumors and/or liver metastases in 401 patients undergoing CLM resection...
August 1, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28763248/evaluating-commercially-available-antibodies-for-rat-%C3%AE-7-nicotinic-acetylcholine-receptors
#19
Brijesh K Garg, Ralph H Loring
Alpha7 nicotinic acetylcholine receptors (α7 nAChRs) are important drug targets in neurological disorders and inflammation, making their detection and localization by validated antibodies highly desirable. However, tests in knockout animals raised questions about specificity of antibodies to mouse α7 nAChRs. To date, methods for validating antibodies for rat or human α7 nAChR have not been reported. We developed a gel-shift assay for western blots using GH4C1 cells expressing either native rat receptors or α7 nAChR-green fluorescent protein (GFP) chimeras to evaluate seven commercially available α7 nAChR antibodies...
September 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28761067/every-other-day-feeding-extends-lifespan-but-fails-to-delay-many-symptoms-of-aging-in-mice
#20
Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S Henzel, Sabine M Hölter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L Pearson, Ildiko Racz, Birgit Rathkolb, Devon P Ryan, Susanne Schröder, Irina Treise, Raffi Bekeredjian, Dirk H Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Dan Ehninger
Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls...
July 24, 2017: Nature Communications
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