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https://www.readbyqxmd.com/read/28075640/toward-developing-clinical-competence-improving-health-care-of-gender-diverse-people
#1
Lore M Dickey
No abstract text is available yet for this article.
February 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28031390/methylphenidate-cognition-and-epilepsy-a-double-blind-placebo-controlled-single-dose-study
#2
Jesse Adams, Valerie Alipio-Jocson, Katherine Inoyama, Victoria Bartlett, Saira Sandhu, Jemima Oso, John J Barry, David W Loring, Kimford Meador
OBJECTIVE: To evaluate the potential efficacy of immediate-release methylphenidate (MPH) for treating cognitive deficits in epilepsy. METHODS: This was a double-blind, randomized, single-dose, 3-period crossover study in patients with epilepsy and chronic cognitive complaints comparing the effects of placebo and MPH 10 and 20 mg given 1 week apart. Cognitive outcome was evaluated on the basis of an omnibus z score calculated from performance on the Conners Continuous Performance Test 3 (ability to discriminate between target and nontarget stimuli [d'] and hit reaction time standard deviation), Symbol-Digit Modalities Test, and Medical College of Georgia Paragraph Memory Test...
December 28, 2016: Neurology
https://www.readbyqxmd.com/read/28010929/dr-galen-wagner-1939-2016-as-an-academic-writer-an-overview-of-his-peer-reviewed-scientific-publications
#3
REVIEW
Olle Pahlm, Cees A Swenne, Sumche Man, Yama Fakhri, Brett D Atwater, Ljuba Bacharova, Lia Bang, Yochai Birnbaum, Esben Carlsson, Peter Clemmensen, Henrik Engblom, Leonard S Gettes, Peer Grande, Nina Hakacova, Lene Holmvang, Birgit Jurlander, Zak Loring, Ulrika Pahlm, Jonas Pettersson, Michael Ringborn, Niels Risum, Maria Sejersten-Ripa, Leif Sörnmo, David G Strauss, Robbert Zusterzeel, Stafford G Warren
No abstract text is available yet for this article.
January 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28009074/new-monoclonal-antibodies-to-defined-cell-surface-proteins-on-human-pluripotent-stem-cells
#4
Carmel M O'Brien, Hun S Chy, Qi Zhou, Shiri Blumenfeld, Jack W Lambshead, Xiaodong Liu, Joshua Kie, Bianca D Capaldo, Tung-Liang Chung, Timothy E Adams, Tram Phan, John D Bentley, William J Mckinstry, Karen Oliva, Paul J Mcmurrick, Yu-Chieh Wang, Fernando J Rossello, Geoffrey J Lindeman, Di Chen, Thierry Jarde, Amander T Clark, Helen E Abud, Jane E Visvader, Christian M Nefzger, Jose M Polo, Jeanne F Loring, Andrew L Laslett
The study and application of human pluripotent stem cells (hPSCs) will be enhanced by the availability of well-characterised monoclonal antibodies (mAbs) detecting cell-surface epitopes. Here we report generation of seven new mAbs that detect cell surface proteins present on live and fixed human ES cells (hESCs) and human iPS cells (hiPSCs), confirming our previous prediction that these proteins were present on the cell surface of hPSCs. The mAbs all show a high correlation with POU5F1 (OCT4) expression and other hPSC surface markers (TRA-160 and SSEA-4) in hPSC cultures and detect rare OCT4 positive cells in differentiated cell cultures...
December 23, 2016: Stem Cells
https://www.readbyqxmd.com/read/28003247/impaired-high-density-lipoprotein-anti-oxidative-function-is-associated-with-outcome-in-patients-with-chronic-heart-failure
#5
Lore Schrutka, Klaus Distelmaier, Philipp Hohensinner, Patrick Sulzgruber, Irene M Lang, Gerald Maurer, Johann Wojta, Martin Hülsmann, Alexander Niessner, Lorenz Koller
BACKGROUND: Oxidative stress is mechanistically linked to the pathogenesis of chronic heart failure (CHF). Antioxidative functions of high-density lipoprotein (HDL) particles have been found impaired in patients with ischemic cardiomyopathy; however, the impact of antioxidative HDL capacities on clinical outcome in CHF patients is unknown. We therefore investigated the predictive value of antioxidative HDL function on mortality in a representative cohort of patients with CHF. METHODS AND RESULTS: We prospectively enrolled 320 consecutive patients admitted to our outpatient department for heart failure and determined antioxidative HDL function using the HDL oxidative index (HOI)...
December 21, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28002834/cost-effectiveness-and-budget-effect-analysis-of-a-population-based-skin-cancer-screening
#6
Lore Pil, Isabelle Hoorens, Katrien Vossaert, Vibeke Kruse, Isabelle Tromme, Niko Speybroeck, Lieven Annemans, Lieve Brochez
Importance: Several epidemiological studies show an alarming global increase in incidence of melanoma and nonmelanoma skin cancer. Objectives: To examine the cost-effectiveness of 2 population-based skin cancer screening methods and to assess their budget effect and the influence on skin cancer epidemiological findings. Design, Setting, and Participants: A Markov model with a latent period of 20 years and a time horizon of 50 years was used to analyze the cost-effectiveness (societal perspective) and budget effect (public health care payer perspective) of 2 population-based skin cancer screening programs in Belgium compared with the absence of a screening program...
December 14, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27997603/socio-ecological-variables-associated-with-context-specific-sitting-time-in-belgian-older-adults-a-one-year-follow-up-study
#7
Cedric Busschaert, Anne-Lore Scherrens, Ilse De Bourdeaudhuij, Greet Cardon, Jelle Van Cauwenberg, Katrien De Cocker
INTRODUCTION: Knowledge about variables associated with context-specific sitting time in older adults is limited. Therefore, this study explored cross-sectional and longitudinal associations of socio-demographic, social-cognitive, physical-environmental and health-related variables with sitting during TV viewing, computer use and motorized transport in older adults. METHODS: A sample of Belgian older adults completed structured interviews on context-specific sitting time and associated variables using a longitudinal study design...
2016: PloS One
https://www.readbyqxmd.com/read/27982545/oral-lichen-planus-therapy-and-phenotype
#8
Bruno Loré, Rosita Saraceno, Giulio Poladas, Monika Fida, Charbel Khoury, Claudio Arcuri, Roberto Magnato
BACKGROUND: Lichen planus (LP) is a mucocutaneous disease of chronic inflammatory nature. Although many therapeutic options are available, none are curative. The aim of this article was to describe a therapeutic algorithm that take into consideration the clinical futures of oral LP (OLP). METHODS: Patients affected by symptomatic OLP were enrolled into three groups to receive cyclosporine mouthwash, retinoic acid lotion 0.05%, and autologous platelet- rich plasma (PRP) gel in the treatment of reticular, plaque-like, and erosive-type respectively...
December 16, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27959841/kidney-stones-composition-frequency-and-relation-to-metabolic-diagnosis
#9
Francisco R Spivacow, Elisa E Del Valle, Ernesto Lores, Paula G Rey
Nephrolithiasis is one of the most frequent urologic diseases. The aim of this paper is to study the composition and frequency of 8854 patient kidney stones and in a subset of them their metabolic risk factors to be related to their type of calculi. Physicochemical and crystallographic methods were used to assess kidney stone composition. In a subset of 715 patients, we performed an ambulatory metabolic protocol with diagnostic purposes. From the total sample 79% of stones were made of calcium salts (oxalate and phosphate), followed by uric acid stones in 16...
2016: Medicina
https://www.readbyqxmd.com/read/27933544/dissection-of-host-susceptibility-to-bacterial-infections-and-its-toxins
#10
Aysar Nashef, Mahmoud Agbaria, Ariel Shusterman, Nicola Ivan Lorè, Alessandra Bragonzi, Ervin Wiess, Yael Houri-Haddad, Fuad A Iraqi
Infection is one of the leading causes of human mortality and morbidity. Exposure to microbial agents is obviously required. However, also non-microbial environmental and host factors play a key role in the onset, development and outcome of infectious disease, resulting in large of clinical variability between individuals in a population infected with the same microbe. Controlled and standardized investigations of the genetics of susceptibility to infectious disease are almost impossible to perform in humans whereas mouse models allow application of powerful genomic techniques to identify and validate causative genes underlying human diseases with complex etiologies...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27923998/interplay-between-h1-and-hmgn-epigenetically-regulates-olig1-2-expression-and-oligodendrocyte-differentiation
#11
Tao Deng, Yuri Postnikov, Shaofei Zhang, Lillian Garrett, Lore Becker, Ildikó Rácz, Sabine M Hölter, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Michael Bustin
An interplay between the nucleosome binding proteins H1 and HMGN is known to affect chromatin dynamics, but the biological significance of this interplay is still not clear. We find that during embryonic stem cell differentiation loss of HMGNs leads to down regulation of genes involved in neural differentiation, and that the transcription factor OLIG2 is a central node in the affected pathway. Loss of HMGNs affects the expression of OLIG2 as well as that of OLIG1, two transcription factors that are crucial for oligodendrocyte lineage specification and nerve myelination...
December 6, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27914009/serum-response-factor-srf-ablation-interferes-with-acute-stress-associated-immediate-and-long-term-coping-mechanisms
#12
Annemarie Zimprich, Gabi Mroz, Christopher Meyer Zu Reckendorf, Sofia Anastasiadou, Philip Förstner, Lillian Garrett, Sabine M Hölter, Lore Becker, Jan Rozman, Cornelia Prehn, Birgit Rathkolb, Kristin Moreth, Wolfgang Wurst, Thomas Klopstock, Martin Klingenspor, Jerzy Adamski, Eckhard Wolf, Raffi Bekeredjian, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Bernd Knöll
Stress experience modulates behavior, metabolism, and energy expenditure of organisms. One molecular hallmark of an acute stress response is a rapid induction of immediate early genes (IEGs) such as c-Fos and Egr family members. IEG transcription in neurons is mediated by the neuronal activity-driven gene regulator serum response factor (SRF). We show a first role of SRF in immediate and long-lasting acute restraint stress (AS) responses. For this, we employed a standardized mouse phenotyping protocol at the German Mouse Clinic (GMC) including behavioral, metabolic, and cardiologic tests as well as gene expression profiling to analyze the consequences of forebrain-specific SRF deletion in mice exposed to AS...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27910599/synthetic-plasma-edge-diagnostics-for-emc3-eirene-highlighted-for-wendelstein-7-x
#13
H Frerichs, F Effenberg, O Schmitz, C Biedermann, Y Feng, M Jakubowski, R König, M Krychowiak, J Lore, H Niemann, T S Pedersen, L Stephey, G A Wurden
Interpretation of spectroscopic measurements in the edge region of high-temperature plasmas can be a challenge since line of sight integration effects make direct interpretation in terms of quantitative, local emission strengths often impossible. The EMC3-EIRENE code-a 3D fluid edge plasma and kinetic neutral gas transport code-is a suitable tool for full 3D reconstruction of such signals. A versatile synthetic diagnostic module has been developed recently which allows the realistic 3D setup of various plasma edge diagnostics to be captured...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910451/preliminary-design-of-a-tangentially-viewing-imaging-bolometer-for-nstx-u
#14
B J Peterson, R Sano, M L Reinke, J M Canik, L F Delgado-Aparicio, J D Lore, K Mukai, T K Gray, G G van Eden, M A Jaworski
The infrared imaging video bolometer (IRVB) measures plasma radiated power images using a thin metal foil. Two different designs with a tangential view of NSTX-U are made assuming a 640 × 480 (1280 × 1024) pixel, 30 (105) fps, 50 (20) mK, IR camera imaging the 9 cm × 9 cm × 2 μm Pt foil. The foil is divided into 40 × 40 (64 × 64) IRVB channels. This gives a spatial resolution of 3.4 (2.2) cm on the machine mid-plane. The noise equivalent power density of the IRVB is given as 113 (46) μW/cm(2) for a time resolution of 33 (20) ms...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910411/design-and-characterization-of-a-prototype-divertor-viewing-infrared-video-bolometer-for-nstx-u
#15
G G van Eden, M L Reinke, B J Peterson, T K Gray, L F Delgado-Aparicio, M A Jaworski, J Lore, K Mukai, R Sano, S N Pandya, T W Morgan
The InfraRed Video Bolometer (IRVB) is a powerful tool to measure radiated power in magnetically confined plasmas due to its ability to obtain 2D images of plasma emission using a technique that is compatible with the fusion nuclear environment. A prototype IRVB has been developed and installed on NSTX-U to view the lower divertor. The IRVB is a pinhole camera which images radiation from the plasma onto a 2.5 μm thick, 9 × 7 cm(2) Pt foil and monitors the resulting spatio-temporal temperature evolution using an IR camera...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27903528/consensus-guidelines-for-the-diagnosis-and-management-of-patients-with-classic-hairy-cell-leukemia
#16
Michael R Grever, Omar Abdel-Wahab, Leslie A Andritsos, Versha Banerji, Jacqueline Barrientos, James S Blachly, Timothy G Call, Daniel Catovsky, Claire Dearden, Judit Demeter, Monica Else, Francesco Forconi, Alessandro Gozzetti, Anthony D Ho, James B Johnston, Jeffrey Jones, Gunnar Juliusson, Eric Kraut, Robert J Kreitman, Loree Larratt, Francesco Lauria, Gerard Lozanski, Emili Montserrat, Sameer A Parikh, Jae H Park, Aaron Polliack, Graeme R Quest, Kanti R Rai, Farhad Ravandi, Tadeusz Robak, Alan Saven, John F Seymour, Tamar Tadmor, Martin S Tallman, Constantine Tam, Enrico Tiacci, Xavier Troussard, Clive S Zent, Thorsten Zenz, Pier Luigi Zinzani, Brunangelo Falini
Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to re-treatment present continuing areas for research. The disease and its effective treatment are associated with immunosuppression. As more patients are being treated with alternative programs, comparison of results will require general agreement on definitions of response, relapse, and methods of determining minimal residual disease...
November 30, 2016: Blood
https://www.readbyqxmd.com/read/27902687/limb-bone-structural-proportions-and-locomotor-behavior-in-a-l-288-1-lucy
#17
Christopher B Ruff, M Loring Burgess, Richard A Ketcham, John Kappelman
While there is broad agreement that early hominins practiced some form of terrestrial bipedality, there is also evidence that arboreal behavior remained a part of the locomotor repertoire in some taxa, and that bipedal locomotion may not have been identical to that of modern humans. It has been difficult to evaluate such evidence, however, because of the possibility that early hominins retained primitive traits (such as relatively long upper limbs) of little contemporaneous adaptive significance. Here we examine bone structural properties of the femur and humerus in the Australopithecus afarensis A...
2016: PloS One
https://www.readbyqxmd.com/read/27901391/comparison-of-antibacterial-effects-among-three-foams-used-with-negative-pressure-wound-therapy-in-an-ex-vivo-equine-perfused-wound-model
#18
COMPARATIVE STUDY
Lore L Van Hecke, Maarten Haspeslagh, Katleen Hermans, Ann M Martens
OBJECTIVE To compare antibacterial effects among 3 types of foam used with negative-pressure wound therapy (NPWT) in an ex vivo equine perfused wound model. SAMPLES Abdominal musculocutaneous flaps from 6 equine cadavers. PROCEDURES Each musculocutaneous flap was continuously perfused with saline (0.9% NaCl) solution. Four 5-cm circular wounds were created in each flap and contaminated with 10(6) CFUs of both Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA). After a 1-hour incubation period, 1 of 4 treatments (NPWT with silver-impregnated polyurethane foam [NPWT-AgPU], polyurethane foam [NPWT-PU], or polyvinyl alcohol foam [NPWT-PVA] or a nonadherent dressing containing polyhexamethylene biguanide without NPWT [control]) was randomly applied to each wound...
December 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27894900/neuroimaging-somatosensory-perception-and-masking
#19
Kimford J Meador, Kathleen Pirog Revill, Charles M Epstein, K Sathian, David W Loring, Chris Rorden
The specific cortical and subcortical regions involved in conscious perception and masking are uncertain. This study sought to identify brain areas involved in conscious perception of somatosensory stimuli during a masking task using functional magnetic resonance (fMRI) to contrast perceived vs. non-perceived targets. Electrical trains were delivered to the right index finger for targets and to the left index finger for masks. Target intensities were adjusted to compensate for threshold drift. Sham target trials were given in ~10% of the trials, and target stimuli without masks were delivered in one of the five runs (68 trials/run)...
January 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/27892514/gwas-study-using-dna-pooling-strategy-identifies-association-of-variant-rs4910623-in-or52b4-gene-with-anti-vegf-treatment-response-in-age-related-macular-degeneration
#20
Moeen Riaz, Laura Lorés-Motta, Andrea J Richardson, Yi Lu, Grant Montgomery, Amer Omar, Robert K Koenekoop, John Chen, Philipp Muether, Lebriz Altay, Tina Schick, Sascha Fauser, Dzenita Smailhodzic, Freekje van Asten, Eiko K de Jong, Carel B Hoyng, Kathryn P Burdon, Stuart MacGregor, Robyn H Guymer, Anneke I den Hollander, Paul N Baird
Pooled DNA based GWAS to determine genetic association of SNPs with visual acuity (VA) outcome in anti-vascular endothelial growth factor (anti-VEGF) treated neovascular age-related macular degeneration (nAMD) patients. We performed pooled DNA based GWAS on 285 anti-VEGF treated nAMD patients using high density Illumina 4.3 M array. Primary outcome was change in VA in Early Treatment Diabetic Retinopathy Study (ETDRS) letters after 6 months of anti-VEGF treatment (patients who lost ≥5 ETDRS letters classified as non-responders and all remaining classified as responders)...
November 28, 2016: Scientific Reports
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