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https://www.readbyqxmd.com/read/29150186/articular-scaling-and-body-mass-estimation-in-platyrrhines-and-catarrhines-modern-variation-and-application-to-fossil-anthropoids
#1
Jonathan M G Perry, Siobhán B Cooke, Jacqueline A Runestad Connour, M Loring Burgess, Christopher B Ruff
Body mass is an important component of any paleobiological reconstruction. Reliable skeletal dimensions for making estimates are desirable but extant primate reference samples with known body masses are rare. We estimated body mass in a sample of extinct platyrrhines and Fayum anthropoids based on four measurements of the articular surfaces of the humerus and femur. Estimates were based on a large extant reference sample of wild-collected individuals with associated body masses, including previously published and new data from extant platyrrhines, cercopithecoids, and hominoids...
November 14, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29134245/esophageal-pressure-research-or-clinical-tool
#2
REVIEW
E Baedorf Kassis, S H Loring, D Talmor
Esophageal manometry has traditionally been utilized for respiratory physiology research, but clinicians have recently found numerous applications within the intensive care unit. Esophageal pressure (PEs) is a surrogate for pleural pressures (PPl), and the difference between airway pressure (PAO) and PEs provides a good estimate for the pressure across the lung also known as the transpulmonary pressure (PL). Differentiating the effects of mechanical ventilation and spontaneous breathing on the respiratory system, chest wall, and across the lung allows for improved personalization in clinical decision making...
November 13, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29133847/female-mice-lacking-pald1-exhibit-endothelial-cell-apoptosis-and-emphysema
#3
Isabel Egaña, Hiroshi Kaito, Anja Nitzsche, Lore Becker, Carolina Ballester-Lopez, Colin Niaudet, Milena Petkova, Wei Liu, Michael Vanlandewijck, Alexandra Vernaleken, Thomas Klopstock, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Helge Rask-Andersen, Henrik J Johansson, Janne Lehtiö, Liqun He, Ali Ö Yildirim, Mats Hellström
Paladin (Pald1, mKIAA1274 or x99384) was identified in screens for vascular-specific genes and is a putative phosphatase. Paladin has also been proposed to be involved in various biological processes such as insulin signaling, innate immunity and neural crest migration. To determine the role of paladin we have now characterized the Pald1 knock-out mouse in a broad array of behavioral, physiological and biochemical tests. Here, we show that female, but not male, Pald1 heterozygous and homozygous knock-out mice display an emphysema-like histology with increased alveolar air spaces and impaired lung function with an obstructive phenotype...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133190/integrating-geriatric-assessment-in-the-first-line-chemotherapy-treatment-in-older-patients-with-metastatic-colorectal-cancer-results-of-a-prospective-observational-cohort-study-avaplus
#4
Lore Decoster, Cindy Kenis, Benedicte Naessens, Ghislain Houbier, Marc De Man, Guy Lambrecht, Els Monsaert, Veerle Moons, Philippe Vergauwe, Hans Prenen, Eric Van Cutsem, Hans Wildiers
OBJECTIVES: This study aims to investigate the use of chemotherapy with or without bevacizumab in older patients with metastatic colorectal cancer (mCRC) in current daily practice and to identify predictive parameters for treatment-related outcomes. PATIENTS AND METHODS: This is a Belgian multi-centre, observational cohort study. Patients≥70years old with mCRC considered suitable for first-line chemotherapy were eligible for inclusion. At baseline geriatric screening and assessment was performed...
November 10, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29107600/inflammation-and-host-pathogen-interaction-cause-and-consequence-in-cystic-fibrosis-lung-disease
#5
Alessandra Bragonzi, Hamed Horati, Lauren Kerrigan, Nicola Ivan Lorè, Bob J Scholte, Sinéad Weldon
Cystic Fibrosis (CF) lung disease is associated with dysregulation of host defence systems, which ultimately disrupts the balance between inflammation and resolution and leaves the host susceptible to repeated infection. However, the mechanisms underlying these defects are complex and continue to garner significant interest among the CF research community. This review explores emerging data on novel aspects of innate host defence with promising biomarker and therapeutic potential for CF lung disease. Improved understanding of inflammation and host defence against pathogens in patients and animal models during the progression of CF lung disease is pivotal for the discovery of new therapeutics that can limit and/or prevent damage from birth...
October 26, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29107052/weekly-observations-of-online-survey-metadata-obtained-through-home-computer-use-allow-for-detection-of-changes-in-everyday-cognition-before-transition-to-mild-cognitive-impairment
#6
Adriana Seelye, Nora Mattek, Nicole Sharma, Thomas Riley, Johanna Austin, Katherine Wild, Hiroko H Dodge, Emily Lore, Jeffrey Kaye
INTRODUCTION: Subtle changes in instrumental activities of daily living often accompany the onset of mild cognitive impairment (MCI) but are difficult to measure using conventional tests. METHODS: Weekly online survey metadata metrics, annual neuropsychological tests, and an instrumental activity of daily living questionnaire were examined in 110 healthy older adults with intact cognition (mean age = 85 years) followed up for up to 3.6 years; 29 transitioned to MCI during study follow-up...
October 26, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29092957/molecular-characterisation-of-metastatic-pancreatic-neuroendocrine-tumours-pnets-using-whole-genome-and-transcriptome-sequencing
#7
Hui-Li Wong, Kevin C Yang, Yaoqing Shen, Eric Y Zhao, Jonathan M Loree, Hagen F Kennecke, Steve E Kalloger, Joanna M Karasinska, Howard J Lim, Andrew J Mungall, Xiaolan Feng, Janine M Davies, Kasmintan Schrader, Chen Zhou, Aly Karsan, Steven Jm Jones, Janessa Laskin, Marco A Marra, David F Schaeffer, Sharon M Gorski, Daniel J Renouf
Pancreatic neuroendocrine tumours (PNETs) are a genomically and clinically heterogeneous group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic mutations, chromosomal aberrations and gene expression signatures in PNETs have been described, but the clinical significance of these molecular changes is still poorly understood, and the clinical outcomes of PNET patients remain highly variable. To help identify the molecular factors that contribute to PNET progression and metastasis, and as part of an ongoing clinical trial at the BC Cancer Agency (clinicaltrials...
November 1, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29073228/using-a-whole-body-31p-birdcage-transmit-coil-and-16-element-receive-array-for-human-cardiac-metabolic-imaging-at-7t
#8
Ladislav Valkovič, Iulius Dragonu, Salam Almujayyaz, Alex Batzakis, Liam A J Young, Lucian A B Purvis, William T Clarke, Tobias Wichmann, Titus Lanz, Stefan Neubauer, Matthew D Robson, Dennis W J Klomp, Christopher T Rodgers
PURPOSE: Cardiac phosphorus magnetic resonance spectroscopy (31P-MRS) provides unique insight into the mechanisms of heart failure. Yet, clinical applications have been hindered by the restricted sensitivity of the surface radiofrequency-coils normally used. These permit the analysis of spectra only from the interventricular septum, or large volumes of myocardium, which may not be meaningful in focal disease. Löring et al. recently presented a prototype whole-body (52 cm diameter) transmit/receive birdcage coil for 31P at 7T...
2017: PloS One
https://www.readbyqxmd.com/read/29067781/report-of-the-international-stem-cell-banking-initiative-workshop-activity-current-hurdles-and-progress-in-seed-stock-banking-of-human-pluripotent-stem-cells
#9
Jung-Hyun Kim, Andreas Kurtz, Bao-Zhu Yuan, Fanyi Zeng, Geoff Lomax, Jeanne F Loring, Jeremy Crook, Ji Hyeon Ju, Laura Clarke, Maneesha S Inamdar, Martin Pera, Meri T Firpo, Michael Sheldon, Nafees Rahman, Orla O'Shea, Patricia Pranke, Qi Zhou, Rosario Isasi, Ruttachuk Rungsiwiwut, Shin Kawamata, Steve Oh, Tenneille Ludwig, Tohru Masui, Thomas J Novak, Tsuneo Takahashi, Wataru Fujibuchi, Soo Kyung Koo, Glyn N Stacey
This article summarizes the recent activity of the International Stem Cell Banking Initiative (ISCBI) held at the California Institute for Regenerative Medicine (CIRM) in California (June 26, 2016) and the Korean National Institutes for Health in Korea (October 19-20, 2016). Through the workshops, ISCBI is endeavoring to support a new paradigm for human medicine using pluripotent stem cells (hPSC) for cell therapies. Priority considerations for ISCBI include ensuring the safety and efficacy of a final cell therapy product and quality assured source materials, such as stem cells and primary donor cells...
November 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29063810/the-use-of-uhear%C3%A2-to-screen-for-hearing-loss-in-older-patients-with-cancer-as-part-of-a-comprehensive-geriatric-assessment
#10
Michelle Lycke, Philip R Debruyne, Tessa Lefebvre, Evi Martens, Lore Ketelaars, Hans Pottel, Koen Van Eygen, Sofie Derijcke, Patrick Werbrouck, Philippe Vergauwe, Karin Stellamans, Philippe Clarysse, Ingeborg Dhooge, Patricia Schofield, Tom Boterberg
OBJECTIVE: We previously validated uHear™ to screen for hearing loss in older patients with cancer without a known hearing loss, as part of a comprehensive geriatric assessment (CGA). In view of low specificity, we tested a new modified uHear™ scoring system as described by Handzel. METHODS: Patients, aged ≥70 years, were evaluated by uHear™ and conventional audiometry, which is considered the gold standard, as part of a CGA. The pass or fail screening cut-off for uHear™ was defined as having ≥2 consecutive hearing grades starting from the moderate-severe threshold zone ranging from 0...
October 24, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29039745/profiling-the-fatty-acids-content-of-ornamental-camellia-seeds-cultivated-in-galicia-by-an-optimized-matrix-solid-phase-dispersion-extraction
#11
Carmen Garcia-Jares, Marta Sanchez-Nande, Juan Pablo Lamas, Marta Lores
Camellia (genus of flowering plants of fam. Theaceae) is one of the main crops in Asia, where tea and oil from leaves and seeds have been utilized for thousands of years. This plant is excellently adapted to the climate and soil of Galicia (northwestern Spain) and northern Portugal where it is grown not only as an ornamental plant, but to be evaluated as a source of bioactive compounds. In this work, the main fatty acids were extracted from Camellia seeds of four varieties of Camellia: sasanqua, reticulata, japonica and sinensis, by means of matrix-solid phase dispersion (MSPD), and analyzed by gas chromatography (GC) with MS detection of the corresponding methyl esters...
October 17, 2017: Bioengineering
https://www.readbyqxmd.com/read/29038053/flagellar-motility-extracellular-proteases-and-vibrio-cholerae-detachment-from-abiotic-and-biotic-surfaces
#12
Loree Mewborn, Jorge A Benitez, Anisia J Silva
Vibrio cholerae of serogroups O1 and O139, the causative agent of Asiatic cholera, continues to be a major global health threat. This pathogen utilizes substratum-specific pili to attach to distinct surfaces in the aquatic environment and the human small intestine and detaches when conditions become unfavorable. Both attachment and detachment are critical to bacterial environmental survival, pathogenesis and disease transmission. However, the factors that promote detachment are less understood. In this study, we examine the role of flagellar motility and hemagglutinin/protease (HapA) in vibrio detachment from a non-degradable abiotic surface and from the suckling mouse intestine...
October 13, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29030319/coordination-of-different-ligands-to-copper-ii-and-cobalt-iii-metal-centers-enhances-zika-virus-and-dengue-virus-loads-in-both-arthropod-cells-and-human-keratinocytes
#13
Shovan Dutta, Michael J Celestine, Supreet Khanal, Alexis Huddleston, Colin Simms, Jessa Faye Arca, Amlan Mitra, Loree Heller, Piotr J Kraj, Michel Ledizet, John F Anderson, Girish Neelakanta, Alvin A Holder, Hameeda Sultana
Trace elements such as copper and cobalt have been associated with virus-host interactions. However, studies to show the effect of conjugation of copper(II) or cobalt(III) metal centers to thiosemicarbazone ligand(s) derived from either food additives or mosquito repellent such as 2-acetylethiazole or citral, respectively, on Zika virus (ZIKV) or dengue virus (serotype 2; DENV2) infections have not been explored. In this study, we show that four compounds comprising of thiosemicarbazone ligand derived from 2-acetylethiazole viz...
January 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29029276/complement-c3-associates-with-incidence-of-diabetes-but-no-evidence-of-a-causal-relationship
#14
Yan Borné, Iram Faqir Muhammad, Laura Lorés-Motta, Bo Hedblad, Peter M Nilsson, Olle Melander, Eiko K de Jong, Anna M Blom, Anneke I den Hollander, Gunnar Engström
Purpose: This study explored whether complement factor 3 (C3) in plasma is associated with incidence of diabetes in a population-based cohort. We also identified genetic variants related to C3 and explored whether C3 and diabetes share common genetic determinants. Methods: C3 was analyzed in plasma from 4368 non-diabetic subjects, 46-68 years old, from the Malmö Diet and Cancer study (MDC). Incidence of diabetes was studied in relation to C3 levels during 17.7±4...
September 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28990169/methylphenidate-cognition-and-epilepsy-a-1-month-open-label-trial
#15
Jesse Adams, Valerie Alipio-Jocson, Katherine Inoyama, Victoria Bartlett, Saira Sandhu, Jemima Oso, John J Barry, David W Loring, Kimford J Meador
OBJECTIVE: Cognitive difficulties are common in epilepsy. Beyond reducing seizures and adjusting antiepileptic medications, no well-validated treatment exists in adults. Methylphenidate is used effectively in children with epilepsy and attention-deficit/hyperactivity disorder, but its effects in adults have not been systematically evaluated. We hypothesized that methylphenidate can safely improve cognition in adults with epilepsy. We detail here the open-label follow-up to a double-blind, placebo-controlled, single-dose study...
October 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28977669/stable-breathing-in-patients-with-obstructive-sleep-apnea-is-associated-with-increased-effort-but-not-lowered-metabolic-rate
#16
Camila M de Melo, Luigi Taranto-Montemurro, James P Butler, David P White, Stephen H Loring, Ali Azarbarzin, Melania Marques, Philip J Berger, Andrew Wellman, Scott A Sands
Study objectives: In principle, if metabolic rate were to fall during sleep in a patient with obstructive sleep apnea (OSA), ventilatory requirements could be met without increased respiratory effort thereby favoring stable breathing. Indeed, most patients achieve periods of stable flow-limited breathing without respiratory events for periods during the night for reasons that are unclear. Thus, we tested the hypothesis that in patients with OSA, periods of stable breathing occur when metabolic rate (VO2) declines...
July 23, 2017: Sleep
https://www.readbyqxmd.com/read/28975622/the-low-affinity-neurotensin-receptor-antagonist-levocabastine-impairs-brain-nitric-oxide-synthesis-and-mitochondrial-function-by-independent-mechanisms
#17
Silvia Lores-Arnaiz, Analía G Karadayian, Alicia Gutnisky, Georgina Rodríguez de Lores Arnaiz
Neurotensin is known to inhibit neuronal Na+, K+ -ATPase, an effect that is rescued by nitric oxide (NO) synthase inhibition. However, whether the neurotensinergic and the nitrergic systems are independent pathways, or are mechanistically linked, is unknown. Here, we addressed this issue and found that the administration of NTS2 antagonist, levocabastine (50 μg/kg, i.p.) inhibited NO synthase (NOS) activity by 74 and 42% after 18 h in synaptosomal and mitochondrial fractions isolated from the Wistar rat cerebral cortex, respectively; these effects disappeared 36 h after levocabastine treatment...
October 4, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28974153/image-memorability-across-longer-time-intervals
#18
Lore Goetschalckx, Pieter Moors, Johan Wagemans
You may find some images easier to remember than others. Recent studies of visual memory have found remarkable levels of consistency for this inter-item variability across observers, suggesting that memorability can be considered an intrinsic image property. The current study replicated and extended previous results, while adopting a more traditional visual long-term memory task with retention intervals of 20 min, one day, and one week, as opposed to the previously used repeat-detection task, which typically relied on short retention intervals (5 min)...
October 3, 2017: Memory
https://www.readbyqxmd.com/read/28966146/understanding-gene-functions-and-disease-mechanisms-phenotyping-pipelines-in-the-german-mouse-clinic
#19
REVIEW
Helmut Fuchs, Juan Antonio Aguilar-Pimentel, Oana V Amarie, Lore Becker, Julia Calzada-Wack, Yi-Li Cho, Lillian Garrett, Sabine M Hölter, Martin Irmler, Martin Kistler, Markus Kraiger, Philipp Mayer-Kuckuk, Kristin Moreth, Birgit Rathkolb, Jan Rozman, Patricia da Silva Buttkus, Irina Treise, Annemarie Zimprich, Kristine Gampe, Christine Hutterer, Claudia Stöger, Stefanie Leuchtenberger, Holger Maier, Manuel Miller, Angelika Scheideler, Moya Wu, Johannes Beckers, Raffi Bekeredjian, Markus Brielmeier, Dirk H Busch, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Tobias Stöger, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Valérie Gailus-Durner, Martin Hrabě de Angelis
Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas...
September 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28958578/efficient-targeting-and-activation-of-antigen-presenting-cells-in%C3%A2-vivo-after-modified-mrna-vaccine-administration-in-rhesus-macaques
#20
Frank Liang, Gustaf Lindgren, Ang Lin, Elizabeth A Thompson, Sebastian Ols, Josefine Röhss, Shinu John, Kimberly Hassett, Olga Yuzhakov, Kapil Bahl, Luis A Brito, Hugh Salter, Giuseppe Ciaramella, Karin Loré
mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because they are well tolerated, immunogenic, and scalable and are built on precise but adaptable antigen design. We show that two immunizations of modified non-replicating mRNA encoding influenza H10 hemagglutinin (HA) and encapsulated in lipid nanoparticles (LNP) induce protective HA inhibition titers and H10-specific CD4(+) T cell responses after intramuscular or intradermal delivery in rhesus macaques. Administration of LNP/mRNA induced rapid and local infiltration of neutrophils, monocytes, and dendritic cells (DCs) to the site of administration and the draining lymph nodes (LNs)...
August 12, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
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