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https://www.readbyqxmd.com/read/28731360/communications-between-pulmonary-airways-and-blood-vessels-a-new-mechanism
#1
Stephen H Loring
No abstract text is available yet for this article.
July 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28730545/platelet-first-responders-in-wound-response-cancer-and-metastasis
#2
REVIEW
David G Menter, Scott Kopetz, Ernest Hawk, Anil K Sood, Jonathan M Loree, Paolo Gresele, Kenneth V Honn
Platelets serve as "first responders" during normal wounding and homeostasis. Arising from bone marrow stem cell lineage megakaryocytes, anucleate platelets can influence inflammation and immune regulation. Biophysically, platelets are optimized due to size and discoid morphology to distribute near vessel walls, monitor vascular integrity, and initiate quick responses to vascular lesions. Adhesion receptors linked to a highly reactive filopodia-generating cytoskeleton maximizes their vascular surface contact allowing rapid response capabilities...
July 20, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28728321/review-of-the-nomenclature-of-the-retaining-ligaments-of-the-cheek-frequently-confused-terminology
#3
Yeui Seok Seo, Jennifer Kim Song, Tae Suk Oh, Seong Ihl Kwon, Tanvaa Tansatit, Joo Heon Lee
Since the time of its inception within facial anatomy, wide variability in the terminology as well as the location and extent of retaining ligaments has resulted in confusion over nomenclature. Confusion over nomenclature also arises with regard to the subcutaneous ligamentous attachments, and in the anatomic location and extent described, particularly for zygomatic and masseteric ligaments. Certain historical terms-McGregor's patch, the platysma auricular ligament, parotid cutaneous ligament, platysma auricular fascia, temporoparotid fasica (Lore's fascia), anterior platysma-cutaneous ligament, and platysma cutaneous ligament-delineate retaining ligaments of related anatomic structures that have been conceptualized in various ways...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28726057/macrophage-migration-inhibitory-factor-mif-modulates-trophic-signaling-through-interaction-with-serine-protease-htra1
#4
Åsa Fex Svenningsen, Svenja Löring, Anna Lahn Sørensen, Ha Uyen Buu Huynh, Simone Hjæresen, Nellie Martin, Jesper Bonnet Moeller, Maria Louise Elkjær, Uffe Holmskov, Zsolt Illes, Malin Andersson, Solveig Beck Nielsen, Eirikur Benedikz
Macrophage migration inhibitory factor (MIF), a small conserved protein, is abundant in the immune- and central nervous system (CNS). MIF has several receptors and binding partners that can modulate its action on a cellular level. It is upregulated in neurodegenerative diseases and cancer although its function is far from clear. Here, we report the finding of a new binding partner to MIF, the serine protease HTRA1. This enzyme cleaves several growth factors, extracellular matrix molecules and is implicated in some of the same diseases as MIF...
July 19, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28724081/genome-wide-screening-for-lectin-motifs-in-arabidopsis-thaliana
#5
Lore Eggermont, Bruno Verstraeten, Els J M Van Damme
For more than three decades, served as a model for plant biology research. At present only a few protein families have been studied in detail in . This study focused on all sequences with lectin motifs in the genome of . Based on amino acid sequence similarity (BLASTp searches), 217 putative lectin genes were retrieved belonging to 9 out of 12 different lectin families. The domain organization and genomic distribution for each lectin family were analyzed. Domain architecture analysis revealed that most of these lectin gene sequences are linked to other domains, often belonging to protein families with catalytic activity...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28722103/decreased-levels-of-active-upa-and-klk8-assessed-by-111-in-mica-401-binding-correlate-with-the-seizure-burden-in-an-animal-model-of-temporal-lobe-epilepsy
#6
Stephan Missault, Lore Peeters, Halima Amhaoul, David Thomae, Annemie Van Eetveldt, Barbara Favier, Anagha Thakur, Jeroen Van Soom, Asla Pitkänen, Koen Augustyns, Jurgen Joossens, Steven Staelens, Stefanie Dedeurwaerdere
OBJECTIVE: Urokinase-type plasminogen activator (uPA) and kallikrein-related peptidase 8 (KLK8) are serine proteases that contribute to extracellular matrix (ECM) remodeling after brain injury. They can be labelled with the novel radiotracer [(111) In]MICA-401. As the first step in exploring the applicability of [(111) In]MICA-401 in tracing the mechanisms of postinjury ECM reorganization in vivo, we performed in vitro and ex vivo studies, assessing [(111) In]MICA-401 distribution in the brain in two animal models: kainic acid-induced status epilepticus (KASE) and controlled cortical impact (CCI)-induced traumatic brain injury (TBI)...
July 19, 2017: Epilepsia
https://www.readbyqxmd.com/read/28715767/non-human-primates-as-a-model-for-understanding-the-mechanism-of-action-of-toll-like-receptor-based-vaccine-adjuvants
#7
REVIEW
Elizabeth A Thompson, Karin Loré
While transgenic mouse models are powerful for understanding how the immune system is manipulated by vaccines, they cannot fully recapitulate the characteristics of the innate immune responses leading to adaptive immunity after vaccination in humans. Outbred non-human primates are far more representative models of human vaccine responses as there is high degree of similarities in immune cell subset distributions, receptor expression (including toll-like receptors; TLRs), and immune cell functions, in addition to modeling doses and injection sites more accurately...
July 14, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28704401/il-13-is-a-central-mediator-of-chemical-induced-airway-hyperreactivity-in-mice
#8
Fien C Devos, Lore Pollaris, Jonathan Cremer, Sven Seys, Tomoaki Hoshino, Jan Ceuppens, Karel Talavera, Benoit Nemery, Peter H M Hoet, Jeroen A J Vanoirbeek
BACKGROUND: While the importance of the Th2 cytokine IL-13 as a central mediator of airway hyperreactivity (AHR) has been described in allergic protein-induced asthma, this has never been investigated in chemical-induced asthma. OBJECTIVE: We examined the importance of IL-13 in a mouse model of chemical-induced AHR, using toluene-2,4-diisocyanate (TDI). METHODS: In a first set-up, wild type (WT) and IL-13 knockout (KO) C57Bl/6 mice were dermally treated on days 1 and 8 with 1% TDI or vehicle (acetone/olive oil) on both ears...
2017: PloS One
https://www.readbyqxmd.com/read/28695538/fgf9-y162c-mutation-alters-information-processing-and-social-memory-in-mice
#9
Lillian Garrett, Lore Becker, Jan Rozman, Oliver Puk, Tobias Stoeger, Ali Önder Yildirim, Alexander Bohla, Oliver Eickelberg, Wolfgang Hans, Cornelia Prehn, Jerzy Adamski, Thomas Klopstock, Ildikó Rácz, Andreas Zimmer, Martin Klingenspor, Helmut Fuchs, Valerie Gailus-Durner, Wolfgang Wurst, Martin Hrabě de Angelis, Jochen Graw, Sabine M Hölter
In neuropsychiatric diseases, such as major depression and anxiety, pathogenic vulnerability is partially dictated by a genetic predisposition. The search continues to define this genetic susceptibility and establish new genetic elements as potential therapeutic targets. The fibroblast growth factors (FGFs) could be interesting in this regard. This family of signaling molecules plays important roles in development while also functioning within the adult. This includes effects on aspects of brain function such as neurogenesis and synapse formation...
July 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28677988/national-palliative-care-capacities-around-the-world-results-from-the-world-health-organization-noncommunicable-disease-country-capacity-survey
#10
Lee Sharkey, Belinda Loring, Melanie Cowan, Leanne Riley, Eric L Krakauer
BACKGROUND: Previous estimates of global palliative care development have not been based on official country data. AIM: The World Health Organization Noncommunicable Disease Country Capacity Survey of World Health Organization member state officials monitors countries' capacities for the prevention and control of noncommunicable diseases. In 2015, for the first time, questions were included on a number of palliative care development metrics to generate baseline data for monitoring global palliative care development...
June 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28654613/evidence-based-medicine-current-evidence-in-the-diagnosis-and-management-of-carpal-tunnel-syndrome
#11
Steven J Hermiz, Loree K Kalliainen
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Create a safe and effective plan for management of carpal tunnel syndrome. 2. Support his or her rationale for the use of diagnostic tests. 3. Discuss elements of management that have been controversial, including anesthesia, the use of a tourniquet, postoperative pain control, and cost of care. SUMMARY: This is the fourth MOC-PS CME article on carpal tunnel syndrome. Each of the prior three has had a slightly different focus, and the reader is invited to review all to generate a comprehensive view of the management of this common, and often controversial, topic...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28651794/airflow-shape-is-associated-with-the-pharyngeal-structure-causing-obstructive-sleep-apnea
#12
Pedro R Genta, Scott A Sands, James P Butler, Stephen H Loring, Eliot S Katz, B Gail Demko, Eric J Kezirian, David P White, Andrew Wellman
BACKGROUND: Obstructive sleep apnea (OSA) results from the collapse of different pharyngeal structures (soft palate, tongue, lateral walls, epiglottis). The structure involved in collapse has been shown to impact non-CPAP OSA treatment. Different inspiratory airflow shapes are also observed among OSA patients. We hypothesized that inspiratory flow shape reflects the underlying pharyngeal structure involved in airway collapse. METHODS: Subjects with OSA were studied with a pediatric endoscope and simultaneous nasal flow and pharyngeal pressure recordings during natural sleep...
June 23, 2017: Chest
https://www.readbyqxmd.com/read/28645892/meis1-effects-on-motor-phenotypes-and-the-sensorimotor-system-in-mice
#13
Aaro V Salminen, Lillian Garrett, Barbara Schormair, Jan Rozman, Florian Giesert, Kristina M Niedermeier, Lore Becker, Birgit Rathkolb, Ildikó Rácz, Martin Klingenspor, Thomas Klopstock, Eckhard Wolf, Andreas Zimmer, Valérie Gailus-Durner, Miguel Torres, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Sabine M Hölter, Juliane Winkelmann
MEIS1 is a developmental transcription factor linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder leading to severe sleep reduction and with significant impact on the quality-of-life of patients. In genome-wide association studies, MEIS1 has consistently been the gene with the highest effect size and functional studies suggest a disease-relevant downregulation. Therefore, haploinsufficiency of Meis1 could be the most potential system for modeling RLS in animals...
June 23, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28632745/evaluating-patterns-and-drivers-of-spatial-change-in-the-recreational-guided-fishing-sector-in-alaska
#14
Maggie N Chan, Anne H Beaudreau, Philip A Loring
Understanding the impacts of recreational fishing on habitats and species, as well as the social and ecological importance of place to anglers, requires information on the spatial distribution of fishing activities. This study documented long-term changes in core fishing areas of a major recreational fishery in Alaska and identified biological, regulatory, social, and economic drivers of spatial fishing patterns by charter operators. Using participatory mapping and in-person interviews, we characterized the spatial footprint of 46 charter operators in the communities of Sitka and Homer since the 1990s...
2017: PloS One
https://www.readbyqxmd.com/read/28632522/relationship-of-reaction-time-to-perception-of-a-stimulus-and-volitionally-delayed-response
#15
Kimford J Meador, Alan Boyd, David W Loring
BACKGROUND AND OBJECTIVE: Initiation of response in a simple reaction time (RT) task may precede conscious perception of the stimulus. Since volitionally delayed responses may require conscious perception of the stimulus before response initiation, it has been hypothesized that volitionally delayed responses will markedly delay RT. METHODS: We conducted two experiments with separate groups of healthy volunteers (n=16; n=13) who performed computerized simple and choice RT tasks...
June 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28629359/forced-expiration-measurements-in-mouse-models-of-obstructive-and-restrictive-lung-diseases
#16
Fien C Devos, André Maaske, Annette Robichaud, Lore Pollaris, Sven Seys, Carolina Aznar Lopez, Erik Verbeken, Matthias Tenbusch, Rik Lories, Benoit Nemery, Peter Hm Hoet, Jeroen Aj Vanoirbeek
BACKGROUND: Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. METHOD: Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively...
June 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28621683/genomic-analysis-of-exceptional-responder-to-regorafenib-in-treatment-refractory-metastatic-rectal-cancer-a-case-report-and-review-of-the-literature
#17
Krittiya Korphaisarn, Jonathan M Loree, Van Nguyen, Ryanne Coulson, Vijaykumar Holla, Beate C Litzenburger, Ken Chen, Gordon B Mills, Dipen M Maru, Funda Meric-Bernstan, Kenna R Mills Shaw, Scott Kopetz
We present the case of a 53-year-old male with metastatic rectal cancer who was treatment resistant to FOLFOX and FOLFOXIRI. Due to a Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation, regorafenib was given in the third line setting. Surprisingly, the patient had a prolonged partial response that lasted 27 months. Mutational status was extensively evaluated to identify potential alterations that might play a role as predictive markers for this unusual event. A poorly characterized but nontransforming mutation in Fms-like tyrosine kinase 4 (FLT4) was present in the tumor...
June 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615063/lineage-specific-rediploidization-is-a-mechanism-to-explain-time-lags-between-genome-duplication-and-evolutionary-diversification
#18
Fiona M Robertson, Manu Kumar Gundappa, Fabian Grammes, Torgeir R Hvidsten, Anthony K Redmond, Sigbjørn Lien, Samuel A M Martin, Peter W H Holland, Simen R Sandve, Daniel J Macqueen
BACKGROUND: The functional divergence of duplicate genes (ohnologues) retained from whole genome duplication (WGD) is thought to promote evolutionary diversification. However, species radiation and phenotypic diversification are often temporally separated from WGD. Salmonid fish, whose ancestor underwent WGD by autotetraploidization ~95 million years ago, fit such a 'time-lag' model of post-WGD radiation, which occurred alongside a major delay in the rediploidization process. Here we propose a model, 'lineage-specific ohnologue resolution' (LORe), to address the consequences of delayed rediploidization...
June 14, 2017: Genome Biology
https://www.readbyqxmd.com/read/28592561/vaccine-priming-is-restricted-to-draining-lymph-nodes-and-controlled-by-adjuvant-mediated-antigen-uptake
#19
Frank Liang, Gustaf Lindgren, Kerrie J Sandgren, Elizabeth A Thompson, Joseph R Francica, Anja Seubert, Ennio De Gregorio, Susan Barnett, Derek T O'Hagan, Nancy J Sullivan, Richard A Koup, Robert A Seder, Karin Loré
The innate immune mechanisms by which adjuvants enhance the potency and protection of vaccine-induced adaptive immunity are largely unknown. We introduce a model to delineate the steps of how adjuvant-driven innate immune activation leads to priming of vaccine responses using rhesus macaques. Fluorescently labeled HIV-1 envelope glycoprotein (Env) was administered together with the conventional aluminum salt (alum) adjuvant. This was compared to Env given with alum with preabsorbed Toll-like receptor 7 (TLR7) ligand (alum-TLR7) or the emulsion MF59 because they show superiority over alum for qualitatively and quantitatively improved vaccine responses...
June 7, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28587095/comparative-study-of-lectin-domains-in-model-species-new-insights-into-evolutionary-dynamics
#20
Sofie Van Holle, Kristof De Schutter, Lore Eggermont, Mariya Tsaneva, Liuyi Dang, Els J M Van Damme
Lectins are present throughout the plant kingdom and are reported to be involved in diverse biological processes. In this study, we provide a comparative analysis of the lectin families from model species in a phylogenetic framework. The analysis focuses on the different plant lectin domains identified in five representative core angiosperm genomes (Arabidopsisthaliana, Glycine max, Cucumis sativus, Oryza sativa ssp. japonica and Oryza sativa ssp. indica). The genomes were screened for genes encoding lectin domains using a combination of Basic Local Alignment Search Tool (BLAST), hidden Markov models, and InterProScan analysis...
May 25, 2017: International Journal of Molecular Sciences
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