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https://www.readbyqxmd.com/read/29786191/-waiting-for-general-data-protection-regulation
#1
EDITORIAL
Filippo Lorè
No abstract text is available yet for this article.
May 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29780706/the-evolving-first-line-treatment-of-advanced-non-small-cell-lung-cancer-harbouring-epidermal-growth-factor-receptor-mutations
#2
EDITORIAL
Lore Decoster, Philippe Giron, Sacha Mignon, Jacques De Grève
No abstract text is available yet for this article.
April 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29770861/the-fate-of-fogli-s-lore-s-fascial-platysma-fixation-optimalising-the-results-of-fogli-s-neck-lift-procedure
#3
Darryl J Hodgkinson
The author has modified previously described techniques of the superior suspension of the platysma muscle to Lore's fascia by developing an auriculoplastysmal fascial flap, which detaches the posterior platysma from its retaining ligaments to the sternomastoid muscle. Anterior to this flap, the platysma muscle is undermined and suture captured with three throws of a permanent 2.0 Tevdek suture. This suture and its three throws are fixed anterior to the tragus, which includes Lore's fascia and on tightening elevates the whole of the anterior neck as well as defines the cervicomental angle...
May 16, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29769448/tlr-adjuvanted-nanoparticle-vaccines-differentially-influence-the-quality-and-longevity-of-responses-to-malaria-antigen-pfs25
#4
Elizabeth A Thompson, Sebastian Ols, Kazutoyo Miura, Kelly Rausch, David L Narum, Mats Spångberg, Michal Juraska, Ulrike Wille-Reece, Amy Weiner, Randall F Howard, Carole A Long, Patrick E Duffy, Lloyd Johnston, Conlin P O'Neil, Karin Loré
Transmission-blocking vaccines (TBVs) are considered an integral element of malaria eradication efforts. Despite promising evaluations of Plasmodium falciparum Pfs25-based TBVs in mice, clinical trials have failed to induce robust and long-lived Ab titers, in part due to the poorly immunogenic nature of Pfs25. Using nonhuman primates, we demonstrate that multiple aspects of Pfs25 immunity were enhanced by antigen encapsulation in poly(lactic-co-glycolic acid)-based [(PLGA)-based] synthetic vaccine particles (SVP[Pfs25]) and potent TLR-based adjuvants...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29767683/large-outbreak-of-hepatitis-c-virus-associated-with-drug-diversion-by-a-healthcare-technician
#5
Sharon Alroy-Preis, Elizabeth R Daly, Christine Adamski, Jodie Dionne-Odom, Elizabeth A Talbot, Fengxiang Gao, Steffany J Cavallo, Katrina Hansen, Jennifer C Mahoney, Erin Metcalf, Carol Loring, Christine Bean, Jan Drobeniuc, Guo-Liang Xia, Saleem Kamili, José T Montero
Background: In May 2012, the New Hampshire (NH) Division of Public Health Services (DPHS) was notified of 4 persons with newly diagnosed hepatitis C virus (HCV) infection at hospital X. Initial investigation suggested a common link to the hospital cardiac catheterization laboratory (CCL) because the infected persons included 3 CCL patients and a CCL technician. NH DPHS initiated an investigation to determine the source and control the outbreak. Methods: NH DPHS conducted site visits, case patient and employee interviews, medical record and medication use review, and employee and patient HCV testing using enzyme immunoassay for anti-HCV, reverse-transcription polymerase chain reaction for HCV RNA, nonstructural 5B (NS5B) and hypervariable region 1 (HVR1) sequencing, and quasispecies analysis...
May 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29753019/psychophysical-and-neuroimaging-responses-to-moving-stimuli-in-a-patient-with-the-riddoch-phenomenon-due-to-bilateral-visual-cortex-lesions
#6
Michael J Arcaro, Lore Thaler, Derek J Quinlan, Simona Monaco, Sarah Khan, Kenneth F Valyear, Rainer Goebel, Gordon N Dutton, Melvyn A Goodale, Sabine Kastner, Jody C Culham
Patients with injury to early visual cortex or its inputs can display the Riddoch phenomenon: preserved awareness for moving but not stationary stimuli. We provide a detailed case report of a patient with the Riddoch phenomenon, MC. MC has extensive bilateral lesions to occipitotemporal cortex that include most early visual cortex and complete blindness in visual field perimetry testing with static targets. Nevertheless, she shows a remarkably robust preserved ability to perceive motion, enabling her to navigate through cluttered environments and perform actions like catching moving balls...
May 9, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29730462/untying-the-gordion-knot-of-targeting-met-in-cancer
#7
REVIEW
Kanwal Raghav, Ann Marie Bailey, Jonathan M Loree, Scott Kopetz, Vijaykumar Holla, Timothy Anthony Yap, Fang Wang, Ken Chen, Ravi Salgia, David Hong
Despite compelling evidence backing the crucial role of a dysregulated MET axis in cancer and a myriad of agents targeting this pathway in active clinical development, the therapeutic value of MET inhibition in cancer oncology remains to be established. Although a series of disappointing clinical trials, at first, lessened fervor for targeting this pathway, investigations continue unabated with a number of novel active compounds entering clinical trials. Suboptimal designs which lacked biomarker selection have been the main reason for these early failures and this has stimulated a more biomarker enriched approach lately...
April 26, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29721152/tumor-cell-death-after-electrotransfer-of-plasmid-dna-is-associated-with-cytosolic-dna-sensor-upregulation
#8
Katarina Znidar, Masa Bosnjak, Nina Semenova, Olga Pakhomova, Loree Heller, Maja Cemazar
Cytosolic DNA sensors are a subgroup of pattern recognition receptors (PRRs) and are activated by the abnormal presence of the DNA in the cytosol. Their activation leads to the upregulation of pro-inflammatory cytokines and chemokines and can also induce cell death. The presence of cytosolic DNA sensors and inflammatory cytokines in TS/A murine mammary adenocarcinoma and WEHI 164 fibrosarcoma cells was demonstrated using real time reverse transcription polymerase chain reaction (RT-PCR), western blotting and enzyme-linked immunosorbent assay (ELISA)...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29718453/molecular-landscape-of-erbb2-erbb3-mutated-colorectal-cancer
#9
Jonathan M Loree, Ann M Bailey, Amber M Johnson, Yao Yu, Wenhui Wu, Christopher A Bristow, Jennifer S Davis, Kenna R Shaw, Russell Broaddus, Kimberly C Banks, Richard B Lanman, Funda Meric-Bernstam, Michael J Overman, Scott Kopetz, Kanwal Raghav
Background: Despite growing therapeutic relevance of ERBB2 amplifications in colorectal cancer (CRC), little is known about ERBB2/ERBB3 mutations. We aimed to characterize these subsets of CRC. Methods: We performed a retrospective analysis of 419 CRC patients from MD Anderson (MDACC) and 619 patients from the Nurses' Health Study (NHS)/Health Professionals Follow-Up Study (HPFS) with tissue sequencing, clinicopathologic, mutational, and consensus molecular subtype (CMS) profiles of ERBB2/ERBB3 mutant patients...
April 27, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29706360/whole-exome-sequencing-in-age-related-macular-degeneration-identifies-rare-variants-in-col8a1-a-component-of-bruch-s-membrane
#10
Jordi Corominas, Johanna M Colijn, Maartje J Geerlings, Marc Pauper, Bjorn Bakker, Najaf Amin, Laura Lores Motta, Eveline Kersten, Alejandro Garanto, Joost A M Verlouw, Jeroen G J van Rooij, Robert Kraaij, Paulus T V M de Jong, Albert Hofman, Johannes R Vingerling, Tina Schick, Sascha Fauser, Eiko K de Jong, Cornelia M van Duijn, Carel B Hoyng, Caroline C W Klaver, Anneke I den Hollander
PURPOSE: Genome-wide association studies and targeted sequencing studies of candidate genes have identified common and rare variants that are associated with age-related macular degeneration (AMD). Whole-exome sequencing (WES) studies allow a more comprehensive analysis of rare coding variants across all genes of the genome and will contribute to a better understanding of the underlying disease mechanisms. To date, the number of WES studies in AMD case-control cohorts remains scarce and sample sizes are limited...
April 26, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29703685/sex-bias-in-hand-surgery-research
#11
REVIEW
Loree K Kalliainen, Ian Wisecarver, Allison Cummings, Jennifer Stone
It has been long recognized that sex-based biases related to participant inclusion exist in research. To help address inequities in research participation, the National Institutes of Health Revitalization Act was passed into law in 1993. Although this act was primarily designed to increase inclusion of females and minorities in research funded by National Institutes of Health, it has also helped raise global awareness of the value of routinely including females and minority groups in research. Subsequent work has demonstrated a continued gap in inclusion of females in medical and surgical research and female animals and cell lines in basic science research...
April 24, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29702489/what-s-new-in-short-bowel-syndrome
#12
Lore Billiauws, Olivier Corcos, Francisca Joly
PURPOSE OF REVIEW: Short bowel syndrome (SBS) is a rare disease but with many complications due to intestinal failure, parenteral nutrition and underlying disease. A better prevention, comprehension and treatment could improve the outcome of these patients. RECENT FINDINGS: Recent studies have been published on acute intestinal failure, first cause of SBS, and gives us strategy to avoid extended intestinal resection and thus SBS. There has been progress in the comprehension of intestinal adaptation, characterized by improvements in intestinal absorption, changes on hormonal secretion, development of a hyperphagia and dysbiosis of the gut microbiota...
April 26, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29701937/mediation-analyses-of-insight-quality-of-life-depression-and-suicidality-results-from-the-face-sz-cohort
#13
Paul Roux, David Misdrahi, Delphine Capdevielle, Bruno Aouizerate, Fabrice Berna, Lore Brunel, Isabelle Chereau, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Catherine Faget-Agius, Sandrine Fonteneau, Franck Gabayet, Pierre Michel Llorca, Jasmina Mallet, Romain Rey, Raphaëlle Richieri, Aurélie Schandrin, Franck Schürhoff, Arnaud Tessier, Pierre Vidailhet, Christine Passerieux, Mathieu Urbach
OBJECTIVE: The relationship between greater insight and increased risk of suicide in patients with schizophrenia is debated. The purpose of this study was to assess whether quality of life (QoL) and depression mediated the association between insight and suicidality. METHODS: Between March 2010 and December 2015, 527 community-dwelling adults with stable schizophrenia according to DSM-IV criteria were included in a multicenter cross-sectional study, the FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Study...
April 17, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29700787/exploring-the-use-of-molecular-biomarkers-for-precision-medicine-in-age-related-macular-degeneration
#14
REVIEW
Laura Lorés-Motta, Eiko K de Jong, Anneke I den Hollander
Precision medicine aims to improve patient care by adjusting medication to each patient's individual needs. Age-related macular degeneration (AMD) is a heterogeneous eye disease in which several pathways are involved, and the risk factors driving the disease differ per patient. As a consequence, precision medicine holds promise for improved management of this disease, which is nowadays a main cause of vision loss in the elderly. In this review, we provide an overview of the studies that have evaluated the use of molecular biomarkers to predict response to treatment in AMD...
April 26, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29687230/correction-to-accelerating-therapeutic-development-through-innovative-trial-design-in-colorectal-cancer
#15
Michael Lam, Jonathan M Loree, Allan Andresson Lima Pereira, Yun Shin Chun, Scott Kopetz
In the original version of this article, which published in Volume 19, Issue 2 (February 2018), the third author's name was captured incorrectly. The proper name is now provided.
April 23, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29685299/the-introduction-of-forensic-advisors-in-belgium-and-their-role-in-the-criminal-justice-system
#16
Sonja Bitzer, Laetitia Heudt, Aurélie Barret, Lore George, Karolien Van Dijk, Fabrice Gason, Bertrand Renard
Forensic advisors (FA) at the National Institute for Criminalistics and Criminology (NICC), generalists in forensic science, act as an advising body to the magistrate to improve communication between the various parties involved in the investigation: magistrate, police and crime scene investigators, and forensic experts. Their role is manifold, but their main objectives are to optimise trace processing by selecting the most pertinent traces in the context of the case and by advising magistrates on the feasibility of forensic analyses in particular circumstances in regards to the latest technical advances...
May 2018: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/29678770/self-reported-pain-in-patients-with-schizophrenia-results-from-the-national-first-step-face-sz-cohort
#17
Guillaume Fond, Laurent Boyer, Meja Andrianarisoa, Ophelia Godin, Ewa Bulzacka, Fabrice Berna, Lore Brunel, Nathalie Coulon, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Thierry D'amato, Hélène Denizot, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Sylvain Leignier, Jasmina Mallet, David Misdrahi, Romain Rey, Christophe Lancon, Christine Passerieux, Aurélie Schandrin, Mathieu Urbach, Pierre Vidailhet, Marion Leboyer, Franck Schurhoff, Pierre-Michel Llorca, M Andrianarisoa, B Aouizerate, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, Danion Jm, T D'Amato, A Deloge, C Delorme, H Denizot, J M Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, R M Honciuc, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, R Rey, C Roman, M Sebilleau, A Schandrin, F Schurhoff, A Tessier, Tronche Am, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek, A Zinetti-Bertschy
INTRODUCTION: Little is known about perception of physical pain in schizophrenia (SZ). Some studies have suggested that patients with SZ may have an increased pain threshold, while others have suggested that patients with SZ may suffer from undetected and untreated high physical pain levels. The objectives of this study were (i) to investigate the prevalence of self-reported physical pain in stabilized SZ subjects, and (ii) to determine whether physical pain was associated with psychiatric characteristics and somatic comorbidities (iii) to determine whether antidepressants and benzodiazepine administration were associated with lower self-reported pain...
April 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29674221/physical-activity-levels-after-treatment-for-breast-cancer-two-year-follow-up
#18
An De Groef, Inge Geraerts, Heleen Demeyer, Elien Van der Gucht, Lore Dams, Carlijn de Kinkelder, Sanne Dukers-van Althuis, Marijke Van Kampen, Nele Devoogdt
OBJECTIVES: Breast cancer treatment can have a considerable large and prolonged impact on activity levels of breast cancer survivors. Therefore, the aim of the present study was to investigate the change in total physical activity level and occupational, sport and household activity levels of breast cancer survivors from preoperatively up to 24 months after breast cancer surgery. Additionally, predictive factors for this change were investigated. METHODS: Patients with primary breast cancer (n = 267) filled in the Flemish Physical Activity Computerized Questionnaire (FPACQ) before surgery and 1, 3, 6, 12 and 24 months after surgery...
April 16, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29662492/rnase-h2-loss-in-murine-astrocytes-results-in-cellular-defects-reminiscent-of-nucleic-acid-mediated-autoinflammation
#19
Kareen Bartsch, Markus Damme, Tommy Regen, Lore Becker, Lillian Garrett, Sabine M Hölter, Katharina Knittler, Christopher Borowski, Ari Waisman, Markus Glatzel, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Björn Rabe
Aicardi-Goutières syndrome (AGS) is a rare early onset childhood encephalopathy caused by persistent neuroinflammation of autoimmune origin. AGS is a genetic disorder and >50% of affected individuals bear hypomorphic mutations in ribonuclease H2 (RNase H2). All available RNase H2 mouse models so far fail to mimic the prominent CNS involvement seen in AGS. To establish a mouse model recapitulating the human disease, we deleted RNase H2 specifically in the brain, the most severely affected organ in AGS. Although RNase H2ΔGFAP mice lacked the nuclease in astrocytes and a majority of neurons, no disease signs were apparent in these animals...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29659570/laboratory-mouse-housing-conditions-can-be-improved-using-common-environmental-enrichment-without-compromising-data
#20
Viola André, Christine Gau, Angelika Scheideler, Juan A Aguilar-Pimentel, Oana V Amarie, Lore Becker, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Dirk Janik, Kristin Moreth, Frauke Neff, Manuela Östereicher, Ildiko Racz, Birgit Rathkolb, Jan Rozman, Raffi Bekeredjian, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Markus Brielmeier, Helmut Fuchs, Martin Hrabé de Angelis
Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without creating a divide between past and future experimental results. Previous small-scale studies have been inconsistent throughout the literature, and it is not yet completely understood whether and how enrichment might endanger comparability of results of scientific experiments...
April 16, 2018: PLoS Biology
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