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https://www.readbyqxmd.com/read/28525912/clinicopathologic-characteristics-of-endometrial-cancer-in-lynch-syndrome-a-french-multicenter-study
#1
Léa Rossi, Marie-Aude Le Frere-Belda, Pierre Laurent-Puig, Bruno Buecher, Antoine De Pauw, Dominique Stoppa-Lyonnet, Geoffroy Canlorbe, Olivier Caron, Bruno Borghese, Chrystelle Colas, Hélène Delhomelle, Nathalie Chabbert-Buffet, Sophie Grandjouan, Fabrice Lecuru, Anne-Sophie Bats
BACKGROUND: Limited data exist on Lynch syndrome (LS)-related endometrial cancer (EC) features. Amsterdam criteria II, commonly used, have poor sensitivity for detection of LS, which is underdiagnosed. AIM: The aim of this study was to describe the clinical and pathological features of LS-related EC among mutation-proven patients. METHODS: We conducted a retrospective study from 1977 to 2013 in 5 hospitals. The inclusion criteria were patients who had a primary EC associated to LS proven by a germline mutation...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28523263/a-rare-case-of-an-autoamputated-ovary-with-mature-cystic-teratoma
#2
Hwi Gon Kim, Yong Jung Song, Yong Jin Na, Juseok Yang, Ook Hwan Choi
Autoamputated ovary with mature cystic teratoma (MCT) is a rarely reported gynecologic entity with an unknown prevalence. A 34-year-old woman referred to our clinic for presumed left ovarian tumor. Pelvic examination, ultrasonography and computed tomography scan revealed a 5-cm, cystic ovarian mass with calcification and fat component, and tumor markers were as follows, cancer antigen (CA) 125; 10.4 U/mL, CA19-9; 2 U/mL. Laparoscopy was performed. The mass was identified in the left adnexal region without any ligamentous or direct connection with the pelvic organs...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28523256/ovarian-volume-in-korean-women-with-polycystic-ovary-syndrome-and-its-related-factors
#3
Young Shin Han, Ah Rha Lee, Hee Kyoung Song, Jeong In Choi, Jang Heub Kim, Mee Ran Kim, Min Jeong Kim
OBJECTIVES: The aim of this study was to determine the relationship of ovarian volume (OV) to age, height, and weight in Korean young women with the polycystic ovary syndrome (PCOS) undergoing ultrasonography (US) and to investigate the relationship between ovarian follicle count and volume on US and serum hormone levels including the levels of the anti-Müllerian hormone (AMH) and gonadotropin. METHODS: A total of 272 Korean nulliparous women aged 15 to 39 years who were newly diagnosed with PCOS at a university hospital were included in this study...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28512173/clinical-utility-of-risk-models-to-refer-patients-with-adnexal-masses-to-specialized-oncology-care-multicenter-external-validation-using-decision-curve-analysis
#4
Laure Wynants, Dirk Timmerman, Jan Verbakel, Antonia Testa, Luca Savelli, Daniela Fischerová, Dorella Franchi, Caroline D Van Holsbeke, Elisabeth Epstein, Wouter Froyman, Stefano Guerriero, Alberto Rossi, Robert Fruscio, Francesco Leone, Tom Bourne, Lil Valentin, Ben Van Calster
To evaluate the utility of pre-operative diagnostic models for ovarian cancer based on ultrasound and/or biomarkers for referring patients to specialized oncology care. The investigated models were RMI, ROMA, and three models from the International Ovarian Tumor Analysis (IOTA) group (LR2, ADNEX, and the Simple Rules risk score, SRRisks). <p>DESIGN: A secondary analysis of prospectively collected data from two cross-sectional cohort studies performed to externally validate diagnostic models.</p> <p>PARTICIPANTS: A total of 2763 patients (2403 in dataset 1 and 360 in dataset 2) from 18 centers (11 oncology centers and 7 non-oncology hospitals) in 6 countries...
May 16, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28505102/bone-protective-effects-of-dried-plum-in-postmenopausal-women-efficacy-and-possible-mechanisms
#5
REVIEW
Bahram H Arjmandi, Sarah A Johnson, Shirin Pourafshar, Negin Navaei, Kelli S George, Shirin Hooshmand, Sheau C Chai, Neda S Akhavan
Osteoporosis is an age-related chronic disease characterized by a loss of bone mass and quality, and is associated with an increased risk of fragility fractures. Postmenopausal women are at the greatest risk of developing osteoporosis due to the cessation in ovarian hormone production, which causes accelerated bone loss. As the demographic shifts to a more aged population, a growing number of postmenopausal women will be afflicted with osteoporosis. Certain lifestyle factors, including nutrition and exercise, are known to reduce the risk of developing osteoporosis and therefore play an important role in bone health...
May 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28504506/-a-very-rare-cause-of-peripheral-precocious-puberty-in-a-girl-ovarian-sex-cord-tumor-with-annular-tubules
#6
Julia Sánchez Zahonero, José A Ruiz Domínguez, Sandra Sánchez Zahonero, M José López García
Sex cord tumor with annular tubules is an extremely uncommon gonadal stromal neoplasm. It represents 0.05-0.6% of all ovarian tumors, according to series. An unusual case is presented in a 6-year-old girl, detected as a result of an isosexual peripheral precocious puberty. The highlight of this case is that no mass attached to the ovary was found, but only a gonadal asymmetry without radiological signs of malignancy. After confirming the presence of tumoral cells by intraoperative biopsy, unilateral salpingo-oophorectomy with ipsilateral para-aortic and pelvic lymphadenectomy was performed...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28502829/primary-ovarian-fibrosarcoma-an-unusual-tumor-in-an-adolescent-case-report-and-review-of-the-pediatric-literature
#7
Bade T Kurtmen, Zafer Dokumcu, Emre Divarci, Gürdeniz Serin, Orkan Ergun, Geylani Ozok, Ahmet Celik
BACKGROUND: Primary ovarian fibrosarcomas are rare and usually observed in perimenopausal and postmenopausal women. Up-to-date, there are only 3 reports of ovarian fibrosarcoma in childhood and adolescence in English literature. In this report, we aimed to present the first pediatric case with advanced staged primary ovarian fibrosarcoma and to compare with previous cases. CASE: A 14-year-old teenage girl was admitted due to a giant abdominal mass. Imaging techniques revealed a giant heterogeneous and vascular ovarian mass...
May 11, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28502062/significantly-lengthened-telomere-in-granulosa-cells-from-women-with-polycystic-ovarian-syndrome-pcos
#8
Duo Wei, Juanke Xie, Baoli Yin, Haoying Hao, Xiaobing Song, Qi Liu, Cuilian Zhang, Yingpu Sun
PURPOSE: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among women at reproductive age. However, its etiology remains poorly understood. Recent studies indicated that telomere length was related to PCOS. However, the association between telomere length and PCOS has only been shown in leucocytes and remained controversial across different studies. To clarify the association between telomere length and PCOS, the current study interrogated telomere length not only in leucocytes, but also in follicular granulosa cells, which is essential for folliculogenesis and steroidogenesis...
May 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28499535/cancer-recognition-and-screening-for-common-breast-disorders-and-malignancy
#9
REVIEW
Constance Bohon
Breast cancer is predicted to be the most common newly diagnosed cancer in women in 2016. Screening mammography is the most commonly used method for the detection of breast cancer in women of average risk. A genetic risk assessment is recommended for women with a greater than 20% to 25% chance of having a predisposition to breast and ovarian cancer. Evaluation of a breast mass begins with a detailed history, assessment for cancer risk, and physical examination.
June 2017: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/28496304/evaluation-of-the-antitumor-activity-of-nov202-a-novel-microtubule-targeting-and-vascular-disrupting-agent
#10
Linda Rickardson, Emma Kutvonen, Satu Orasniemi, Marita Högberg, Marko J Kallio, Stefan Rehnmark
PURPOSE: Overall, ~65% of patients diagnosed with advanced ovarian cancer (OC) will relapse after primary surgery and adjuvant first-line platinum- and taxane-based chemotherapy. Significant improvements in the treatment of OC are expected from the development of novel compounds having combined cytotoxic and antiangiogenic properties that make them effective on refractory tumors. METHODS: Permeability of NOV202 was determined with Caco-2 monolayer assay. The compound's pharmacokinetic profile and plasma:brain distribution were assessed in male C57Bl/6 mice...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28494279/gastrointestinal-stromal-tumor-presenting-as-a-right-adnexal-mass-with-histopathologic-correlation
#11
Etan Dayan, Hongfa Zhu, Alan B Copperman, Sara Lewis, Amita Kamath
The authors report and discuss a rare case of a gastrointestinal stromal tumor (GIST) in a 35-year-old female, which was pre-procedurally characterized as a right ovarian mass by magnetic resonance imaging (MRI) features. This manuscript reviews the imaging and clinical features of GISTs with pathologic correlation, and emphasizes how this entity may present a diagnostic challenge in certain anatomic regions owing in large part to its exophytic nature. This case is unique among similarly reported cases in that there was a "claw sign" with the right ovary, which provided convincing evidence of its point of origin...
May 5, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28491194/leptomeningeal-carcinomatosis-and-bilateral-internal-auditory-canal-metastases-from-ovarian-carcinoma
#12
Martin Krupa, Kathy Byun
Ovarian cancer, a leading cause of death in women, typically spreads locally and rarely metastasizes to the brain or seeds the leptomeninges. We present a case of a 62-year-old woman with a history of treated ovarian cell carcinoma who developed bilateral sensorineural deafness and right-sided facial weakness and on imaging was found to have bilateral internal auditory canal (IAC) masses and leptomeningeal carcinomatosis, pathologically proven by cerebrospinal fluid cytology. We discuss her magnetic resonance imaging and positron emission tomography-computed tomography findings and review the imaging characteristics of IAC metastases...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28491011/an-integrated-proteomic-and-glycoproteomic-approach-uncovers-differences-in-glycosylation-occupancy-from-benign-and-malignant-epithelial-ovarian-tumors
#13
Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B S Roden, Hui Zhang, Daniel W Chan
BACKGROUND: Epithelial ovarian carcinomas encompass a heterogeneous group of diseases with a poor 5-year survival rate. Serous carcinoma is the most common type. Most FDA-approved serum tumor markers are glycoproteins. These glycoproteins on cell surface or shed into the bloodstream could serve as therapeutic targets as well as surrogates of tumor. In addition to glycoprotein expressions, the analysis of protein glycosylation occupancy could be important for the understanding of cancer biology as well as the identification of potential glycoprotein changes in cancer...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28488545/determination-of-braf-v600e-ve1-protein-expression-and-braf-gene-mutation-status-in-codon-600-in-borderline-and-low-grade-ovarian-cancers
#14
Pawel Sadlecki, Pawel Walentowicz, Magdalena Bodnar, Andrzej Marszalek, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
Epithelial ovarian tumors are a group of morphologically and genetically heterogeneous neoplasms. Based on differences in clinical phenotype and genetic background, ovarian neoplasms are classified as low-grade and high-grade tumor. Borderline ovarian tumors represent approximately 10%-20% of all epithelial ovarian masses. Various histological subtypes of ovarian malignancies differ in terms of their risk factor profiles, precursor lesions, clinical course, patterns of spread, molecular genetics, response to conventional chemotherapy, and prognosis...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28486623/platinum-induced-mitochondrial-dna-mutations-confer-lower-sensitivity-to-paclitaxel-by-impairing-tubulin-cytoskeletal-organization
#15
Giulia Girolimetti, Flora Guerra, Luisa Iommarini, Ivana Kurelac, Daniele Vergara, Michele Maffia, Michele Vidone, Laura Benedetta Amato, Giulia Leone, Sabrina Dusi, Valeria Tiranti, Anna Myriam Perrone, Cecilia Bucci, Anna Maria Porcelli, Giuseppe Gasparre
Development of chemoresistance is a cogent clinical issue in oncology, whereby combination of anticancer drugs is usually preferred also to enhance efficacy. Paclitaxel (PTX), combined with carboplatin, represents the standard first-line chemotherapy for different types of cancers. We here depict a double-edge role of mitochondrial DNA (mtDNA) mutations induced in cancer cells after treatment with platinum. MtDNA mutations were positively selected by PTX, and they determined a decrease in the mitochondrial respiratory function, as well as in proliferative and tumorigenic potential, in terms of migratory and invasive capacity...
May 9, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28485985/breast-metastases-from-extramammary-malignancies-multimodality-imaging-aspects
#16
Almir G V Bitencourt, Roberta R M Gama, Luciana Graziano, Erika M S Negrão, Silvia M P S Sabino, Anapaula H U Watanabe, Camila S Guatelli, Juliana A Souza, Edmundo C Mauad, Elvira F Marques
Breast metastases from extramammary cancers are rare and usually related to poor prognosis. The extramammary tumors most frequently exhibiting breast metastases are melanoma, lymphomas, ovarian cancer, lung, neuroendocrine tumors, and sarcomas. Due to the lack of reliable and specific clinical or radiological signs for the diagnosis of breast metastases, a combination of techniques is needed to differentiate these lesions from primary breast carcinoma or even benign breast lesions. Multiple imaging methods may be used to evaluate these patients, including mammography, ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography (PET/CT)...
May 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28485364/a-review-of-squamous-cell-carcinoma-arising-in-mature-cystic-teratoma-of-the-ovary
#17
N Abhilasha, U D Bafna, V R Pallavi, P S Rathod, S Krishnappa
INTRODUCTION: Germ cell tumors account for 20-25% of ovarian neoplasms. Mature cystic teratoma (MCT) is the most common ovarian germ cell tumor. Malignancy in MCT is seen in 1-2% of the cases. Squamous cell carcinoma (SCC) accounts for 80% of the cases and carries a poor prognosis. AIM: To study the clinicopathological factors, management protocols and its outcome. MATERIALS AND METHODS: Case records reviewed from August 2006 to August 2011 at our institute identified 10 women with SCC in ovarian MCT...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28485195/is-routine-adnexal-scanning-for-postmenopausal-bleeding-of-value-observational-study-of-2101-women
#18
Shagaf Bakour, Emmanuel Emovon, James Nevin, Ayman A A Ewies
Our objective is to assess the merits of adnexal scanning during the investigation of women with postmenopausal bleeding (PMB) in terms of adnexal cancer diagnosis. This observational study was designed utilising an institutional PMB database in a teaching hospital, analysing a sample of 2101 consecutive women with PMB seen between 16th February 2012 and 12th August 2014 looking at the prevalence of cancer in adnexal masses identified on Trans-vaginal ultrasound scanning (TVS) in these PMB women. This study suggests that routine adnexal scanning in women with PMB may provide no benefit...
May 9, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28484923/circulating-levels-of-obesity-related-markers-and-risk-of-renal-cell-carcinoma-in-the-plco-cancer-screening-trial
#19
Linda M Liao, Jonathan N Hofmann, Eunyoung Cho, Michael N Pollak, Wong-Ho Chow, Mark P Purdue
PURPOSE: Obesity is an established risk factor for renal cell carcinoma (RCC). It is unclear what biologic mechanisms underlie this association, although recent evidence suggests that the effects of circulating hormones such as insulin-like growth factors (IGF) and adipokines may play a role. METHODS: To address this question, we conducted a nested case-control study of RCC (252 cases, 252 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial investigating associations with pre-diagnostic serum levels of total adiponectin, high-molecular-weight (HMW) adiponectin, IGF-1, IGF-binding protein-3 (IGFBP-3), and C-peptide...
May 8, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28479754/effect-of-body-mass-index-on-the-outcome-of-in-vitro-fertilization-intracytoplasmic-sperm-injection-in-women
#20
Manish Banker, Dipesh Sorathiya, Sandeep Shah
BACKGROUND: Obesity, a known epidemic, is a leading cause of various reproductive disorders. Association of body mass index (BMI) with pregnancy outcomes, either ovarian or endometrial, is controversial and least elucidated. AIM: This study aimed to analyze the effect of BMI on in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcome in women using self-oocytes, embryos prepared from donor oocytes (DE), or vitrified/frozen embryos (VE) obtained from both the SE and DE groups...
January 2017: Journal of Human Reproductive Sciences
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