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https://www.readbyqxmd.com/read/29775895/ozone-therapy-prevents-the-onset-of-dysplasia-in-hpv16-transgenic-mice-a-pre-clinical-efficacy-and-safety-analysis
#1
C Peirone, V F Mestre, B Medeiros-Fonseca, B Colaço, M J Pires, T Martins, R M Gil da Costa, M J Neuparth, R Medeiros, M M S M Bastos, J A Marques-Magallanes, P A Oliveira
Infection with high-risk human papillomavirus (HPV), most often HPV16, is associated with the development of anogenital and oropharyngeal cancers. Recently, ozone therapy was reported to have considerable efficacy against rabbit VX2 tumors, induced by the cottontail rabbit papillomavirus. The present study aims to determine whether similar results can be obtained in HPV16-transgenic mice, possibly paving the way for new therapeutic options against HPV-induced cancers. HPV16-transgenic and wild-type, female, 20 weeks-old mice were injected intraperitoneally with medical O3 /O2 (80░mL/kg, at O3 50░μg/mL), once a day, for 5 consecutive days...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775416/downregulation-of-the-%C3%AE-1-and-%C3%AE-1-subunit-of-sgc-in-arterial-smooth-muscle-cells-of-opscc-is-hpv-independent
#2
Y Korkmaz, H C Roggendorf, O G Siefer, J Seehawer, T Imhof, M Plomann, W Bloch, A Friebe, C U Huebbers
The nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC) is a heterodimeric enzyme with an α and β subunit. NO binds to heme of the β1 -subunit of sGC, activates the enzyme in the reduced heme iron state in vascular smooth muscle cells (VSMCs), and generates cGMP-inducing vasodilatation and suppression of VSMC proliferation. In the complex tumor milieu with higher levels of reactive oxygen species (ROS), sGC heme iron may become oxidized and insensitive to NO. To change sGC from an NO-insensitive to NO-sensitive state or NO-independent manner, protein expression of sGC in VSMC is required...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29774396/tumor-volume-as-a-prognostic-marker-in-p16-positive-and-p16-negative-oropharyngeal-cancer-patients-treated-with-definitive-intensity-modulated-radiotherapy
#3
Timo Carpén, Kauko Saarilahti, Caj Haglund, Antti Markkola, Jussi Tarkkanen, Jaana Hagström, Petri Mattila, Antti Mäkitie
PURPOSE: To investigate the impact of primary gross tumor volume (pGTV) and nodal gross tumor volume (nGTV) in oropharyngeal squamous cell carcinoma (OPSCC) and the difference in their role between human papillomavirus (HPV)-positive and HPV-negative patients. METHODS: The patient cohort consists of 91 OPSCC patients treated with definitive radiochemotherapy or radiotherapy using intensity-modulated radiotherapy (IMRT). All patients had a minimum follow-up of 31 months...
May 17, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29774116/human-papilloma-virus-global-research-architecture-assessed-by-density-equalizing-mapping
#4
Dörthe Brüggmann, Luise Kayser, Jenny Jaque, Matthias Bundschuh, Doris Klingelhöfer, David A Groneberg
Human papilloma virus (HPV) infection is linked to cervical cancer, which represents the world's fourth most common cancer in women. So far, no detailed map of the worldwide HPV research architecture has been constructed. Hence, this study focuses on the chronological development and geographical distribution of the global HPV-specific publications and evaluates citation-based parameters as well as socioeconomic features of the publishing countries. In total, 29,330 HPV-related publications were identified...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29774091/sensitive-molecular-detection-of-small-nodal-metastasis-in-uterine-cervical-cancer-using-hpv16-e6-ck19-muc1-cancer-biomarkers
#5
Vanessa Samouëlian, Nawel Mechtouf, Eric Leblanc, Guillaume B Cardin, Valérie Lhotellier, Denis Querleu, Françoise Révillion, Francis Rodier
Metastatic nodal involvement is a critical prognostic factor in uterine cervical cancer (UCC). To improve current methods of detecting UCC metastases in lymph nodes (LNs), we used quantitative PCR (qPCR) to assess mRNA expression of potential metastatic biomarkers. We found that expression of HPV16-E6, cytokeratin19 (CK19), and mucin1 (MUC1) is consistently upregulated in tumors and metastatic tissues, supporting a role for these genes in UCC progression. These putative biomarkers were able to predict the presence of histologically positive metastatic LNs with respective sensitivities and specificities of 82% and 99% (CK19), 76% and 95% (HPV16-E6), and 76% and 78% (MUC1)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29774090/strong-sod2-expression-and-hpv-16-18-positivity-are-independent-events-in-cervical-cancer
#6
Silvia Helena Rabelo-Santos, Lara Termini, Enrique Boccardo, Sophie Derchain, Adhemar Longatto-Filho, Maria Antonieta Andreoli, Maria Cecília Costa, Rafaella Almeida Lima Nunes, Liliana Aparecida Lucci Ângelo-Andrade, Luisa Lina Villa, Luiz Carlos Zeferino
It is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasia grade 3 (CIN3), squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Strong SOD2 expression was significantly higher in ADC (82%) than CIN3 (52%) or SCC (64%)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773816/experimental-investigation-of-radiobiology-in-head-and-neck-cancer-cell-lines-as-a-function-of-hpv-status-by-mtt-assay
#7
Paul Reid, Puthenparampil Wilson, Yanrui Li, Loredana G Marcu, Alexander H Staudacher, Michael P Brown, Eva Bezak
Head and neck cancers (HNCs) are aggressive epithelial tumours frequently treated using radiation. HNC biology shows distinctions dependent on the oncologic involvement of the human papilloma virus (HPV). Clinically, HPV positive HNCs respond better to radiotherapy but few in vitro data demonstrate radiobiological differences explaining differences in clinical outcomes. This pilot study examined radiobiological responses to irradiation and subsequent regeneration in two HNC cell lines (HPV positive and negative)...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773702/exploring-variation-in-human-papillomavirus-vaccination-uptake-in-switzerland-a-multilevel-spatial-analysis-of-a-national-vaccination-coverage-survey
#8
Maurane Riesen, Garyfallos Konstantinoudis, Phung Lang, Nicola Low, Christoph Hatz, Mirjam Maeusezahl, Anne Spaar, Marc Bühlmann, Ben D Spycher, Christian L Althaus
OBJECTIVE: Understanding the factors that influence human papillomavirus (HPV) vaccination uptake is critically important to the design of effective vaccination programmes. In Switzerland, HPV vaccination uptake (≥1 dose) by age 16 years among women ranges from 31% to 80% across 26 cantons (states). Our objective was to identify factors that are associated with the spatial variation in HPV vaccination uptake. METHODS: We used cross-sectional data from the Swiss National Vaccination Coverage Survey 2009-2016 on HPV vaccination status (≥1 dose) of 14-17-year-old girls, their municipality of residence and their nationality for 21 of 26 cantons (n=8965)...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29771616/predictors-of-human-papillomavirus-vaccine-follow-through-among-privately-insured-us-patients
#9
Jennifer C Spencer, Noel T Brewer, Justin G Trogdon, Stephanie B Wheeler, Stacie B Dusetzina
OBJECTIVES: To assess predictors of timely human papillomavirus (HPV) vaccine follow-through among privately insured individuals initiating the 3-dose series. METHODS: Using MarketScan Commercial claims data, we identified 1 332 217 privately insured US individuals aged 9 to 26 years who initiated the bivalent or quadrivalent HPV vaccine series from 2006 to 2014, with follow-up data extending through 2015. The study outcome was receipt of third HPV dose within 12 months of the first, compared by year of initiation...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29771378/detection-of-incident-anal-high-risk-hpv-dna-in-msm-incidence-or-reactivation
#10
Denise E Twisk, Marianne A B van der Sande, Arne van Eeden, Daniëlle A M Heideman, Fiona R M van der Klis, Henry J C de Vries, Maarten F Schim van der Loeff
Background: We aimed to assess whether sexual exposure may explain all incident anal HPV detections among men who have sex with men (MSM). Methods: A longitudinal study among MSM was conducted between 2010 and 2013 with six-monthly visits and up to 24 months of follow-up. Risk-factor questionnaires, blood samples, and anal and penile self-swabs were collected at each visit. Self-swabs were used for detection and genotyping of HPV by SPF10-PCR/DEIA/LiPA25 system...
May 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29771169/associations-between-skin-rash-treatment-outcome-and-single-nucleotide-polymorphisms-in-head-and-neck-cancer-patients-receiving-the-egfr-inhibitor-zalutumumab-results-from-the-dahanca-19-trial
#11
Line Brøndum, Jan Alsner, Brita Singers Sørensen, Christian Maare, Jørgen Johansen, Hanne Primdahl, Jan Folkvard Evensen, Claus Andrup Kristensen, Lisbeth Juhler Andersen, Jens Overgaard, Jesper Grau Eriksen
PURPOSE: To study the associations between development of moderate to severe skin rash, clinical outcome, and single nucleotide polymorphisms (SNPs) in candidate genes in head and neck cancer patients from the DAHANCA 19 trial receiving the EGFR-inhibitor zalutumumab concurrently with radiation treatment. MATERIAL AND METHODS: 310 patients were included from the zalutumumab-arm of the DAHANCA 19 study. Nine SNPs in the candidate genes EGFR, EGF, AREG, FCGR2A, FCGR3A, and CCND1 were successfully determined in 294 patients...
May 17, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29770611/the-changing-aetiology-of-head-and-neck-squamous-cell-cancer-a-tale-of-three-cancers
#12
Steven J Thomas, Chris M Penfold, Andrea Waylen, Andrew R Ness
Head and neck cancers are the sixth most common cancers worldwide and an important cause of ill health.(1) Each year about 9000 cases are reported in the UK.(2) Survival is poor and despite advances in treatment, has not improved until recently.(3) The majority of head and neck cancers are squamous cell carcinomas, affecting the larynx, oropharynx and oral cavity. The aetiology is changing and this has implications for prevention and treatment. Twenty years ago, tobacco and alcohol consumption were considered to be the established risk factors and it was estimated that these risk factors accounted for about 75% of cases...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29770079/summary-of-the-naci-update-on-the-recommended-use-of-human-papillomavirus-hpv-vaccine-nine-valent-hpv-vaccine-two-dose-immunization-schedule-and-the-use-of-hpv-vaccines-in-immunocompromised-populations
#13
S L Deeks, M C Tunis, S Ismail
Background: Human papillomavirus (HPV) infections are the most common sexually transmitted infections. In the absence of vaccination, it is estimated that 75% of sexually active Canadians will have an HPV infection at some point in their lives. HPV vaccine programs were first recommended by Canada's National Advisory Committee on Immunization (NACI) in 2007. In addition to the existing HPV vaccine options in Canada, NACI recently recommended the use of a newly authorized nine-valent HPV (HPV9) vaccine according to a 3-dose immunization schedule for the prevention of HPV types 6-, 11-, 16-, 18-, 31-, 33-, 45-, 52- and 58-related cancers and anogenital warts in females aged 9 to 45 years and males aged 9 to 26 years...
June 1, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769604/macrophage-cytokines-enhance-cell-proliferation-of-normal-prostate-epithelial-cells-through-activation-of-erk-and-akt
#14
Tu Dang, Geou-Yarh Liou
Macrophage infiltrations (inflammation) are associated with prostate disorders such as prostatitis, prostatic hyperplasia and prostate cancer. All prostate disorders have elevated cell proliferation, and are initiated from normal prostate epithelial cells. To date, the mechanism of how macrophages regulate normal prostate epithelial cell proliferation remains largely unknown. Using a 3D co-culture system, we here show that Raw 264.7 macrophages increased cell proliferation of normal prostate epithelial PZ-HPV-7 cells...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768678/the-ideal-strategy-for-cervical-cancer-screening-in-japan-result-from-the-fukui-cervical-cancer-screening-study
#15
T Kurokawa, T Onuma, A Shinagawa, Y Chino, M Kobayashi, Y Yoshida
OBJECTIVE: The aims of the Fukui Cervical Cancer Screening (FCCS) study are to determine the frequency of women with high-risk HPV (hrHPV), whether HPV16 or HPV18 (HPV16/18), in the Japanese cancer screening population for the first time and to identify the best strategy for cervical cancer screening in Japan. METHODS: This study enrolled 7,584 women ≥25 years of age who were undergoing routine screening. All women underwent liquid-based cytology and cobas HPV tests...
May 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29767739/efficacy-immunogenicity-and-safety-of-a-9-valent-human-papillomavirus-vaccine-subgroup-analysis-of-participants-from-asian-countries
#16
S M Garland, P Pitisuttithum, H Y S Ngan, C-H Cho, C-Y Lee, C-A Chen, Y C Yang, T-Y Chu, N-F Twu, R Samakoses, Y Takeuchi, T H Cheung, S C Kim, L-M Huang, B-G Kim, Y-T Kim, K-H Kim, Y-S Song, S Lalwani, J-H Kang, M Sakamoto, H-S Ryu, N Bhatla, H Yoshikawa, M C Ellison, S R Han, E Moeller, S Murata, M Ritter, M Sawata, C Shields, A Walia, G Perez, A Luxembourg
Background: A 9-valent human papillomavirus-6/11/16/18/31/33/45/52/58 (9vHPV) vaccine extends coverage to 5 next most common oncogenic types (31/33/45/52/58) in cervical cancer versus quadrivalent HPV (qHPV) vaccine. We describe efficacy, immunogenicity, and safety in Asian participants (India, Hong Kong, South Korea, Japan, Taiwan, and Thailand) from 2 international studies: a randomized, double-blinded, qHPV vaccine-controlled efficacy study (young women aged 16-26 years; NCT00543543; Study 001); and an immunogenicity study (girls and boys aged 9-15 years; NCT00943722; Study 002)...
May 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#17
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765068/linking-cervicovaginal-immune-signatures-hpv-and-microbiota-composition-in-cervical-carcinogenesis-in-non-hispanic-and-hispanic-women
#18
Paweł Łaniewski, Dominique Barnes, Alison Goulder, Haiyan Cui, Denise J Roe, Dana M Chase, Melissa M Herbst-Kralovetz
While high-risk human papillomavirus (HPV) infection is a well-established risk factor for cervical cancer, there are likely other factors within the local microenvironment that contribute to cervical carcinogenesis. Here we investigated relationships between HPV, vaginal pH, vaginal microbiota (VMB) composition, level of genital immune mediators and severity of cervical neoplasm. We enrolled women with low- and high-grade cervical dysplasia (LGD, HGD), invasive cervical carcinoma (ICC), and healthy controls...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765009/parent-provider-communication-of-hpv-vaccine-hesitancy
#19
Laura A Shay, Austin S Baldwin, Andrea C Betts, Emily G Marks, Robin T Higashi, Richard L Street, Donna Persaud, Jasmin A Tiro
: media-1vid110.1542/5754332185001PEDS-VA_2017-2312 Video Abstract OBJECTIVES: To prevent human papillomavirus (HPV)-related cancers, providers must effectively communicate with HPV vaccine-hesitant parents. Here, we developed a typology characterizing parent-provider communication around HPV vaccine hesitancy. METHODS: We audio-recorded 43 visits with unvaccinated adolescents at 6 pediatric clinics in Dallas, Texas in which parents were undecided about HPV vaccination. We qualitatively coded how parents verbally expressed hesitancy (assertive response, asking a question, or expressing concern) and whether providers responded with acquiescence (agree to defer vaccination) and/or persistence (continue discussion)...
May 15, 2018: Pediatrics
https://www.readbyqxmd.com/read/29764400/low-cost-hpv-testing-and-the-prevalence-of-cervical-infection-in-asymptomatic-populations-in-guatemala
#20
Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales, Victor Argueta, Andert Rosingh, Femke J H B van Aerde-van Nunen, Griselda Lopez, Herbert M Pinedo, Mark Schiffman, Michael Dean, Roberto Orozco
BACKGROUND: A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determine the most prevalent HPV types and the distribution of HPV infections in over 1795 cancer-free women in Guatemala undergoing primary screening for cervical cancer by cytology...
May 15, 2018: BMC Cancer
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