Jessica Magid-Bernstein, Jennifer Yan, Alison L Herman, Zili He, Conor W Johnson, Hannah Beatty, Rachel Choi, Sofia Velazquez, Eitan Neeman, Guido Falcone, Jennifer Kim, Nils Petersen, Emily J Gilmore, Charles Matouk, Kevin Sheth, Lauren Sansing
BACKGROUND: The inflammatory response within the central nervous system is a key driver of secondary brain injury after hemorrhagic stroke, both in patients with intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage (aSAH). In this study, we aimed to characterize inflammatory molecules in the blood and cerebrospinal fluid (CSF) of patients within 72 hours of hemorrhage to understand how such molecules vary across disease types and disease severity. METHODS: Biological samples were collected from patients admitted to a single-center Neurosciences Intensive Care Unit with a diagnosis of ICH or aSAH between 2014 and 2022...
December 7, 2023: medRxiv