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https://www.readbyqxmd.com/read/28927264/comparative-interactomes-of-vrk1-and-vrk3-with-their-distinct-roles-in-the-cell-cycle-of-liver-cancer
#1
Namgyu Lee, Dae-Kyum Kim, Seung Hyun Han, Hye Guk Ryu, Sung Jin Park, Kyong-Tai Kim, Kwan Yong Choi
Vaccinia-related kinase 1 (VRK1) and VRK3 are members of the VRK family of serine/threonine kinases and are principally localized in the nucleus. Despite the crucial roles of VRK1/ VRK3 in physiology and disease, the molecular and functional interactions of VRK1/VRK3 are poorly understood. Here, we identified over 200 unreported VRK1/VRK3-interacting candidate proteins by affinity purification and LC-MS/MS. The networks of VRK1 and VRK3 interactomes were found to be associated with important biological processes such as the cell cycle, DNA repair, chromatin assembly, and RNA processing...
August 31, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28927258/a-proteomics-based-approach-reveals-differential-regulation-of-visceral-adipose-tissue-proteins-between-metabolically-healthy-and-unhealthy-obese-patients
#2
Assim A Alfadda, Afshan Masood, Mohammed Y Al-Naami, Pierre Chaurand, Hicham Benabdelkamel
Obesity and the metabolic disorders that constitute metabolic syndrome are a primary cause of morbidity and mortality in the world. Nonetheless, the changes in the proteins and the underlying molecular pathways involved in the relevant pathogenesis are poorly understood.In this study a proteomic analysis of the visceral adipose tissue isolated from metabolically healthy and unhealthy obese patients was used to identify presence of altered pathway(s) leading to metabolic dysfunction. Samples were obtained from 18 obese patients undergoing bariatric surgery and were subdivided into two groups based on the presence or absence of comorbidities as defined by the International Diabetes Federation...
September 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28926988/quality-assessment-of-platelet-rich-fibrin-like-matrix-prepared-from-whole-blood-samples-after-extended-storage
#3
Hideo Kawabata, Kazushige Isobe, Taisuke Watanabe, Toshimitsu Okudera, Masayuki Nakamura, Masashi Suzuki, Jietsu Ryu, Yutaka Kitamura, Hajime Okudera, Kazuhiro Okuda, Koh Nakata, Tomoyuki Kawase
The platelet-rich fibrin-like matrix (PRFM) is usually prepared onsite and immediately used for regenerative therapy. Nonetheless, to meet the clinical necessity of preserving the PRFM without quality deterioration, we developed a method for preparation of PRFMs from short-term-stored whole blood (WB) samples. In this study, to evaluate the practical expiration date of storage, we extended the storage time of WB samples from 2 to 7 days and assessed the quality of the resulting PRFMs. WB samples collected with acid-citrate-dextrose were stored with gentle agitation at ambient temperature...
September 18, 2017: Biomedicines
https://www.readbyqxmd.com/read/28926952/medium-access-control-protocols-for-cognitive-radio-ad-hoc-networks-a-survey
#4
REVIEW
Mahdi Zareei, A K M Muzahidul Islam, Sabariah Baharun, Cesar Vargas-Rosales, Leyre Azpilicueta, Nafees Mansoor
New wireless network paradigms will demand higher spectrum use and availability to cope with emerging data-hungry devices. Traditional static spectrum allocation policies cause spectrum scarcity, and new paradigms such as Cognitive Radio (CR) and new protocols and techniques need to be developed in order to have efficient spectrum usage. Medium Access Control (MAC) protocols are accountable for recognizing free spectrum, scheduling available resources and coordinating the coexistence of heterogeneous systems and users...
September 16, 2017: Sensors
https://www.readbyqxmd.com/read/28926941/why-ubiquitin-has-not-evolved
#5
Douglas C Allan, James C Phillips
Ubiquitin, discovered less than 50 years ago, tags thousands of diseased proteins for destruction. It is small (only 76 amino acids), and is found unchanged in mammals, birds, fish, and even worms, indicating that ubiquitin is perfect. Key features of its functionality are identified here using critical point thermodynamic scaling theory. These include synchronized pivots and hinges, a stabilizing central pivot, and Fano interference between first- and second-order elements of correlated long-range (allosteric) globular surface shape transitions...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28926843/the-genetic-basis-of-delayed-puberty
#6
S R Howard, Leo Dunkel
<br>The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes including short stature, reduced bone mineral density and compromised psychosocial health. Self-limited delayed puberty (DP) is a highly heritable trait, which often segregates in an autosomal dominant pattern; however, its neuroendocrine pathophysiology and genetic regulation remain unclear. Some insights into the genetic mutations that lead to familial DP have come from sequencing genes known to cause GnRH deficiency, most recently via next generation sequencing, and others from large-scale genome wide association studies in the general population...
September 18, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28926812/isotope-and-microbiome-data-provide-complementary-information-to-identify-natural-nitrate-attenuation-processes-in-groundwater
#7
Elena Hernández-Del Amo, Anna Menció, Frederic Gich, Josep Mas-Pla, Lluís Bañeras
Natural attenuation processes alleviate the impact of fertilization practices on groundwater resources. Therefore, identifying the occurrence of denitrification has become a requirement for water quality management. Several approaches are useful for this purpose, such as isotopic and microbiological methods, each of them providing distinct but complementary information about denitrification reactions, attenuation rates and their occurrence in the aquifer. In this paper, we investigate the contribution of both approaches to describe denitrification in a consolidated rock aquifer (limestone and marls), with a porosity related to fracture networks located in the northeastern sector of the Osona basin (NE Spain)...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28926795/dissociable-intrinsic-functional-networks-support-noun-object-and-verb-action-processing
#8
Huichao Yang, Qixiang Lin, Zaizhu Han, Hongyu Li, Luping Song, Lingjuan Chen, Yong He, Yanchao Bi
The processing mechanism of verbs-actions and nouns-objects is a central topic of language research, with robust evidence for behavioral dissociation. The neural basis for these two major word and/or conceptual classes, however, remains controversial. Two experiments were conducted to study this question from the network perspective. Experiment 1 found that nodes of the same class, obtained through task-evoked brain imaging meta-analyses, were more strongly connected with each other than nodes of different classes during resting-state, forming segregated network modules...
September 16, 2017: Brain and Language
https://www.readbyqxmd.com/read/28926778/korean-immigrants-don-t-buy-health-insurance-the-influences-of-culture-on-self-employed-korean-immigrants-focusing-on-structure-and-functions-of-social-networks
#9
Hyunsung Oh, Chung Hyeon Jeong
Culture has been pinpointed as a culprit of disparities in health insurance coverage between Korean immigrants and other ethnic groups. This study explored specific mechanisms by which culture influences a decision to buy health insurance among self-employed Korean immigrants living in ethnic enclaves by focusing on the structure and functions of social networks. Between March and June 2015, we recruited 24 Korean immigrant adults (aged 18 or older) who identified as self-employed and being uninsured for substantial periods before 2014 in Southern California...
September 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28926760/laminin-%C3%AE-5-substrates-promote-survival-network-formation-and-functional-development-of-human-pluripotent-stem-cell-derived-neurons-in-vitro
#10
Anu Hyysalo, Mervi Ristola, Meeri E-L Mäkinen, Sergei Häyrynen, Matti Nykter, Susanna Narkilahti
Laminins are one of the major protein groups in the extracellular matrix (ECM) and specific laminin isoforms are crucial for neuronal functions in the central nervous system in vivo. In the present study, we compared recombinant human laminin isoforms (LN211, LN332, LN411, LN511, and LN521) and laminin isoform fragment (LN511-E8) in in vitro cultures of human pluripotent stem cell (hPSC)-derived neurons. We showed that laminin substrates containing the α5-chain are important for neuronal attachment, viability and network formation, as detected by phase contrast imaging, viability staining, and immunocytochemistry...
September 12, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28926475/altered-resting-state-functional-connectivity-of-default-mode-network-and-sensorimotor-network-in-heavy-metal-music-lovers
#11
Yan Sun, Congcong Zhang, Shuxia Duan, Xiaoxia Du, Vince D Calhoun
The aim of this study was to investigate the spontaneous neural activity and functional connectivity (FC) in heavy metal music lovers (HMML) compared with classical music lovers (CML) during resting state. Forty HMML and 31 CML underwent resting-state functional MRI scans. Fractional amplitude of low-frequency fluctuations (fALFF) and seed-based resting-state FC were computed to explore regional activity and functional integration. A voxel-based two-sample t-test was used to test the differences between the two groups...
September 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28926431/epigenetic-regulation-of-dendritic-cell-development-and-function
#12
Yuanyuan Tian, Lijun Meng, Yi Zhang
The immune system is characterized by the generation of structurally and functionally heterogeneous immune cells that constitute complex innate and adaptive immunity. This heterogeneity of immune cells results from changes in the expression of genes without altering DNA sequence. To achieve this heterogeneity, immune cells orchestrate the expression and functional status of transcription factor (TF) networks, which can be broadly categorized into 3 classes: pioneer TFs that facilitate initial commitment and differentiation of hematopoietic cells, subset-specific TFs that promote the generation of selected cell lineages, and immune-signaling TFs that regulate specialized function in differentiated cells...
September 2017: Cancer Journal
https://www.readbyqxmd.com/read/28926232/prediction-errors-of-molecular-machine-learning-models-lower-than-hybrid-dft-error
#13
Felix A Faber, Luke Hutchison, Bing Huang, Justin Gilmer, Samuel S Schoenholz, George E Dahl, Oriol Vinyals, Steven Kearnes, Patrick F Riley, O Anatole von Lilienfeld
We investigate the impact of choosing regres- sors and molecular representations for the construction of fast machine learning (ML) models of thirteen electronic ground-state properties of organic molecules. The performance of each regressor/representation/property combination is assessed using learning curves which report out- of-sample errors as a function of training set size with up to ∼118k distinct molecules. Molecular structures and properties at hybrid density functional theory (DFT) level of theory come from the QM9 database [Ramakrishnan et al, Scientific Data 1 140022 (2014)] and include enthalpies and free energies of atomization , HOMO/LUMO energies and gap, dipole moment, polarizability, zero point vibrational energy, heat capacity and the highest fundamental vibrational frequency...
September 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28926230/formation-and-characterization-of-hydrogen-boride-sheets-derived-from-mgb2-by-cation-exchange
#14
Hiroaki Nishino, Takeshi Fujita, Nguyen Thanh Cuong, Satoshi Tominaka, Masahiro Miyauchi, Soshi Iimura, Akihiko Hirata, Naoto Umezawa, Susumu Okada, Eiji Nishibori, Asahi Fujino, Tomohiro Fujimori, Shin-Ichi Ito, Junji Nakamura, Hideo Hosono, Takahiro Kondo
Two-dimensional (2D) materials are promising for applications in a wide range of fields because of their unique properties. Hydrogen boride sheets, a new 2D material recently predicted from theory, exhibit intriguing electronic and mechanical properties as well as hydrogen storage capacity. Here, we report the experimental realization of 2D hydrogen boride sheets with an empirical formula of H1B1, produced by exfoliation and complete ion-exchange between protons and magnesium cations in magnesium diboride (MgB2) with an average yield of 42...
September 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28926228/facile-synthesis-of-unique-cellulose-triacetate-based-flexible-and-high-performance-gel-polymer-electrolyte-for-lithium-ion-batteries
#15
Trupti Nirmale, Indrapal Karbhal, Ramchandra S Kalubarme, Manjusha V Shelke, Anjani J Varma, Bharat Bhanudas Kale
Lithium ion batteries (LIBs) with polymer based electrolytes have attracted huge attention due to the possibility of fabricating intrinsically safer and flexible devices. However, economical and eco-friendly sustainable technology is an oncoming challenge to fulfill the ever increasing demand. To circumvent this issue, we have developed gel polymer electrolyte (GPE) based on renewable polymers like cellulose triacetate (CTA) and poly (polyethylene glycol methacrylate) p(PEGMA) by using a photo polymerization technique...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28926182/water-dynamics-and-proton-transport-mechanisms-of-nafion%C3%A2-117-phosphotungstic-acid-composite-membrane-a-molecular-dynamics-study
#16
Saeed Akbari, Mohammad Taghi Hamed Mosavian, Ali Ahmadpour, Fatemeh Moosavi
Nafion®/phosphotungstic acid composite membrane and impact of varying concentration of heteropoly acid (HPA) on the well-known effective mechanisms of proton transport were investigated using classical and quantum hopping molecular dynamics simulation. Our simulations demonstrated that the HPA particles exhibited a favorable influence on Grotthuss mechanism in proton transportation at low hydration levels. From radial distribution function examinations, it was found that HPA particles were solvated with water and also exhibited stronger affinity toward hydronium ions...
September 19, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28926154/brain-functional-connectome-abnormalities-in-als-are-associated-with-disability-and-cortical-hyperexcitability
#17
Nimeshan Geevasinga, Mayuresh S Korgaonkar, Parvathi Menon, Mehdi Van den Bos, Lavier Gomes, Sheryl Foster, Matthew C Kiernan, Steve Vucic
OBJECTIVE: The present study utilized a multimodality approach encompassing connectome network combined with brain volume analysis, and assessment of cortical excitability to provide novel insights into amyotrophic lateral sclerosis (ALS) pathogenesis. METHODS: Magnetic resonance images (MRI) were acquired using a 3.0 Tesla GE Signa HDx scanner, using an 8-channel head coil. MR images for the resting state scan were acquired using echo planar imaging MR sequence, acquiring 40 contiguous axial/oblique slices...
September 19, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28926148/biodiversity-and-species-competition-regulate-the-resilience-of-microbial-biofilm-community
#18
Kai Feng, Zhaojing Zhang, Weiwei Cai, Wenzong Liu, Meiying Xu, Huaqun Yin, Aijie Wang, Zhili He, Ye Deng
The relationship between biodiversity and ecosystem stability is poorly understood in microbial communities. Biofilm communities in small bioreactors called microbial electrolysis cells (MEC) contain moderate species numbers and easy tractable functional traits, thus providing an ideal platform for verifying ecological theories in microbial ecosystems. Here, we investigated the resilience of biofilm communities with a gradient of diversity, and explored the relationship between biodiversity and stability in response to a pH shock...
September 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28926061/network-based-modelling-and-percolation-analysis-of-conformational-dynamics-and-activation-in-the-cdk2-and-cdk4-proteins-dynamic-and-energetic-polarization-of-the-kinase-lobes-may-determine-divergence-of-the-regulatory-mechanisms
#19
G M Verkhivker
The overarching goal of delineating molecular principles underlying differentiation of the activation mechanisms in cyclin-dependent kinases (CDKs) is important for understanding regulatory divergences among closely related kinases which can be exploited in drug discovery of targeted and allosteric inhibitors. To systematically characterize dynamic, energetic and network signatures of the activation mechanisms, we combined atomistic simulations and elastic network modeling with the analysis of the residue interaction networks and rigidity decomposition of the CDK2-cyclin A and CDK4-cyclin D1/D3 complexes...
September 19, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28926054/efficient-incorporation-of-diverse-components-into-metal-organic-frameworks-via-metal-phenolic-networks
#20
Yangke Long, Ling Xiao, Qihua Cao, Xiaowen Shi, Yunan Wang
Metal phenolic networks (MPNs) were used for the first time for the construction of core@shell MOF materials. Diverse functional nanocores with different shapes and sizes could be coated with ZIF-8 shells mediated by MPNs. The obtained Fe3O4@TA-Fe(3+)@ZIF-8 powder showed a superhydrophobic nature which could efficiently absorb n-hexane from water.
September 19, 2017: Chemical Communications: Chem Comm
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