Haohua Yuan, Huan Gui, Shuanghui Chen, Lan Zhu, Chenglv Wang, Qianyu Jing, Hang Lv, Quan Wan, Shuyi Wang, Shengwen Zhou, Xiaodong Ren, Yingjie Nie, Linzhao Li
PURPOSE: This study aimed to develop a novel and feasible modification strategy to improve the solubility and antitumor activity of resiquimod (R848) by utilizing the supramolecular effect of 2-hydroxypropyl-beta-cyclodextrin (2-HP-β-CD). METHODS: R848-loaded PLGA nanoparticles modified with 2-HP-β-CD (CD@R848@NPs) were synthesized using an enhanced emulsification solvent-evaporation technique. The nanoparticles were then characterized in vitro by several methods, such as scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, particle size analysis, and zeta potential analysis...
2024: International Journal of Nanomedicine