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Hepatobiliary cancer

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https://www.readbyqxmd.com/read/29761833/hepatobiliary-and-pancreatic-pancreatic-cancer-with-elevated-serum-igg4-level-due-to-multiple-myeloma-mimicking-localized-autoimmune-pancreatitis
#1
S Kato, M Kuwatani, K Kawakubo, R Sugiura, K Hirata, S Tanikawa, T Mitsuhashi, S Shiratori, N Sakamoto
No abstract text is available yet for this article.
May 15, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29737954/-90-y-radioembolization-for-hepatic-malignancy-in-patients-with-previous-biliary-intervention-multicenter-analysis-of-hepatobiliary-infections
#2
Kavi K Devulapalli, Nicholas Fidelman, Michael C Soulen, Matthew Miller, Matthew S Johnson, Eric Addo, Ghassan El-Haddad, Charles Nutting, James Morrison, Khashayar Farsad, R Peter Lokken, Ron C Gaba, Jacob Fleming, Daniel B Brown, Sharon W Kwan, Steven C Rose, Kevin A Pennycooke, David M Liu, Sarah B White, Ripal Gandhi, Ann A Lazar, Robert K Kerlan
Purpose To determine the frequency of hepatobiliary infections after transarterial radioembolization (TARE) with yttrium 90 (90 Y) in patients with liver malignancy and a history of biliary intervention. Materials and Methods For this retrospective study, records of all consecutive patients with liver malignancy and history of biliary intervention treated with TARE at 14 centers between 2005 and 2015 were reviewed. Data regarding liver function, 90 Y dosimetry, antibiotic prophylaxis, and bowel preparation prophylaxis were collected...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29700559/-primary-sclerosing-cholangitis-current-diagnostics-and-treatment
#3
REVIEW
T Liwinski, C Schramm
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown etiology. Characteristic features are multifocal strictures and dilatations of the bile ducts. In 60-80 % of cases the PSC is strongly associated with chronic inflammatory bowel disease, mostly in the form of pancolitis. The diagnosis is established based on detection of typical cholangiographic lesions of the bile ducts and exclusion of secondary causes of sclerosing cholangitis. There is no approved medical treatment, but in Germany ursodeoxycholic acid is frequently used...
April 26, 2018: Der Internist
https://www.readbyqxmd.com/read/29692213/identification-of-inequalities-in-the-selection-of-liver-surgery-for-colorectal-liver-metastases-in-sweden
#4
A Norén, P Sandström, K Gunnarsdottir, B Ardnor, B Isaksson, G Lindell, M Rizell
BACKGROUND: Liver resection for colorectal liver metastases offers a 5-year survival rate of 25%-58%. This study aimed to analyze whether patients with colorectal liver metastases undergo resection to an equal extent and whether selection factors play a role in the selection process. MATERIAL AND METHODS: Data were retrieved from the Swedish Colorectal Cancer Registry (2007-2011) for colorectal cancer and colorectal liver metastases. The patients identified were linked to the Swedish Registry of Liver and Bile surgery and the National Patient Registry to identify whether liver surgery or ablative treatment was performed...
April 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29651565/synthesis-and-preclinical-evaluation-of-novel-18-f-labeled-glu-urea-glu-based-psma-inhibitors-for-prostate-cancer-imaging-a-comparison-with-18-f-dcfpyl-and-18-f-psma-1007
#5
Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius, Thomas Günther, Behrooz Hooshyar Yousefi, Markus Schwaiger, Hans-Jürgen Wester
BACKGROUND: Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific radiolabeled PSMA ligands. To address the continuously growing clinical demand for 18 F-labeled PSMA-probes, we developed two novel Glu-urea-Glu-(EuE)-based inhibitors, EuE-k-18 F-FBOA (1) and EuE-k-β-a-18 F-FPyl (2), both with optimized linker structure and different 18 F-labeled aromatic moieties...
April 12, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29602584/stomach-dose-volume-predicts-acute-gastrointestinal-toxicity-in-chemoradiotherapy-for-locally-advanced-pancreatic-cancer
#6
D L P Holyoake, D R Warren, C Hurt, M Aznar, M Partridge, S Mukherjee, M A Hawkins
AIMS: Gastrointestinal toxicity impedes dose escalation in chemoradiotherapy for hepatobiliary malignancies. Toxicity risk depends on clinical and radiotherapy metrics. We aimed to identify predictive factors using data from two prospective phase II clinical trials of locally advanced pancreatic cancer (LAPC). MATERIALS AND METHODS: Ninety-one patients with available data from the ARCII (59.4 Gy in 33 fractions with gemcitabine, cisplatin and nelfinavir, n = 23) and SCALOP (50...
March 27, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29579478/surgical-resection-versus-systemic-therapy-for-breast-cancer-liver-metastases-results-of-a-european-case-matched-comparison
#7
A Ruiz, R van Hillegersberg, S Siesling, C Castro-Benitez, M Sebagh, D A Wicherts, K M de Ligt, L Goense, S Giacchetti, D Castaing, J Morère, R Adam
BACKGROUND: Resection of breast cancer liver metastases (BCLM) combined with systemic treatment is increasingly accepted but not offered as therapeutic option. New evidence of the additional value of surgery in these patients is scarce while prognoses without surgery remains poor. PATIENTS AND METHODS: For this case matched analysis, all nationally registered patients with BCLM confined to the liver in the Netherlands (systemic group; N = 523) were selected and compared with patients who received systemic treatment and underwent hepatectomy (resection group; N = 139) at a hepatobiliary centre in France...
March 23, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29573058/molecular-genomic-landscapes-of-hepatobiliary-cancer
#8
REVIEW
Tatsuhiro Shibata, Yasuhito Arai, Yasushi Totoki
Hepatocellular carcinoma (HCC) and biliary tract cancer (BTC) are more frequent in East Asia including Japan. Compiling 1,340 multi-ethnic HCC genomes, the largest cohort ever reported, identified comprehensive landscape of HCC driver genes, which constitutes three core drivers (TP53, TERT and WNT signaling) and combination of infrequent alterations in various cancer pathways. By contrast, five core driver genes (TP53, ARID1A, KRAS, SMAD4 and BAP1) with characteristic molecular alterations including fusion transcripts involving FGFR2 and the PKA pathway, and IDH1/2 mutation constituted the BTC genomes...
March 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29570185/-laparoscopy-in-liver-surgery
#9
László Piros, Zoltán Máthé
More than 9000 laparoscopic liver resections (LLR) are performed worldwide for benign lesions, malignancy (mainly for hepatocellular carcinoma and colorectal cancer liver metastasis), and living donor hepatectomy. Although there is no absolute size criterion, smaller, peripheral lesions (<5 cm) of the anteriolateral segments, that lie far from major vessels and anticipated transection planes are most amenable to LLR, but nowadays lesions of the less ideal posterosuperior segments are feasible for LLR too...
March 23, 2018: Magyar Onkologia
https://www.readbyqxmd.com/read/29564184/how-does-the-tumor-microenvironment-play-a-role-in-hepatobiliary-tumors
#10
REVIEW
Fathima Kamil, Julie H Rowe
The tumor microenvironment (TME) is defined as the structural and dynamic network of cellular and non-cellular interactions between malignant cells and the surrounding non-malignant matrix. Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are two of the most challenging gastrointestinal malignancies. Despite clinical advancements in understanding tumor biology and growth of the chemotherapeutic industry, there have been no corresponding improvements in prognosis and overall survival of HCC and PDAC...
February 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29549474/contributions-of-magnetic-resonance-imaging-to-gastroenterological-practice-mris-for-gis
#11
REVIEW
Christopher G Roth, Dina Halegoua-De Marzio, Flavius F Guglielmo
MRI has transformed from the theoretical, investigative realm to mainstream clinical medicine over the past four decades and has become a core component of the diagnostic toolbox in the practice of gastroenterology (GI). Its success is attributable to exquisite contrast and the ability to isolate specific proton species through the use of different pulse sequences (i.e., T1-weighted, T2-weighted, diffusion-weighted) and exploiting extracellular and hepatobiliary contrast agents. Consequently, MRI has gained preeminence in various GI clinical applications: liver and pancreatic lesion evaluation and detection, liver transplantation evaluation, pancreatitis evaluation, Crohn's disease evaluation (using MR enterography) rectal cancer staging and perianal fistula evaluation...
March 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29541193/neutrophil-to-lymphocyte-ratio-predicts-overall-survival-of-patients-with-combined-hepatocellular-cholangiocarcinoma
#12
Chaobin He, Yize Mao, Xiangming Lao, Shengping Li, Xiaojun Lin
The neutrophil-to-lymphocyte ratio (NLR) has been regarded as a prognostic factor in various types of cancer. The present study aimed to identify the association between NLR and combined hepatocellular cholangiocarcinoma (cHCC-CC) in patients who underwent surgical resection. The present study retrospectively reviewed 59 patients who were diagnosed with cHCC-CC and treated with surgical resection between January 2000 and October 2014 at the Department of Hepatobiliary and Pancreatic Surgery at Sun Yat-sen University Cancer Center (Guangzhou, China)...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29528845/preclinical-evaluation-of-severely-defective-manganese-based-nanocrystal-as-a-liver-specific-contrast-media-for-mr-imaging-comparison-with-gd-eob-dtpa-and-mndpdp
#13
Yu Zhang, Xiao-Ping Xiao, Ting Shu, Jing Cai, Xin-Lan Xiao, Yan-Shu Li, Zhong-Wei Zhang, Qun Tang
Manganese-based (chemically formulated of KMnF3 ) nanocrystal was evaluated as a liver-specific contrast agent for MR imaging and its imaging performance was also compared with those of two commercial hepatobiliary contrast media (Gd-EOB-DTPA and MnDPDP). KMnF3 nanocrystal was post-treated using a plasma technique to cause severe defects, leading to appropriate water dispersibility and high relaxivity. Severely defective KMnF3 nanocrystal (SD-KMnF3 ) has characteristic high tolerance, as evidenced by cytotoxicity on the macrophage cell, and acute and subchronic toxicity on the healthy mouse...
June 1, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29518206/the-science-of-obesity-management-an-endocrine-society-scientific-statement
#14
George A Bray, William E Heisel, Ashkan Afshin, Michael D Jensen, William H Dietz, Michael Long, Robert F Kushner, Stephen R Daniels, Thomas A Wadden, Adam G Tsai, Frank B Hu, John M Jakicic, Donna H Ryan, Bruce M Wolfe, Thomas H Inge
The prevalence of obesity, measured by body mass index, has risen to unacceptable levels in both men and women in the United States and worldwide with resultant hazardous health implications. Genetic, environmental, and behavioral factors influence the development of obesity, and both the general public and health professionals stigmatize those who suffer from the disease. Obesity is associated with and contributes to a shortened life span, type 2 diabetes mellitus, cardiovascular disease, some cancers, kidney disease, obstructive sleep apnea, gout, osteoarthritis, and hepatobiliary disease, among others...
April 1, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29487568/the-growth-hormone-receptor-mechanism-of-receptor-activation-cell-signaling-and-physiological-aspects
#15
REVIEW
Farhad Dehkhoda, Christine M M Lee, Johan Medina, Andrew J Brooks
The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal, gastrointestinal, and reproductive systems. In addition, growth hormone signaling is an important regulator of aging and plays a significant role in cancer development. Growth hormone activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29479701/survival-of-patients-with-hepatobiliary-tract-and-duodenal-cancer-sites-in-germany-and-the-united-states-in-the-early-21st-century
#16
Dianne Pulte, Janick Weberpals, Chloé Charlotte Schröder, Katharina Emrich, Bernd Holleczek, Alexander Katalinic, Sabine Luttmann, Eunice Sirri, Lina Jansen, Hermann Brenner
Hepatobiliary tract cancers (HBTCs) are a heterogeneous group of cancers with high mortality. Because most of these cancers, with the exception of hepatocellular carcinoma (HCC), are rare, few data are available concerning the population level survival expectations of patients with HBTC. Here, we describe survival of patients with HBTC in Germany with comparison to survival in the US. Therefore, data were extracted from 12 databases in Germany and the Surveillance, Epidemiology and End Results (SEER13) database in the US...
February 26, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29464972/malignant-transformation-arising-within-unusual-and-rare-hepatic-lesions-fibropolycystic-disease-form-of-ductal-plate-malformation-and-biliary-adenofibroma
#17
Darren Chua, Adrian Kah Heng Chiow, Tiing Leong Ang, Lai Mun Wang
Cholangiocarcinoma is the second most common hepatobiliary cancer following hepatocellular carcinoma, and 20% to 25% are intrahepatic. We describe 2 cases of intrahepatic cholangiocarcinoma arising within unusual and rare hepatic lesions, fibropolycystic liver disease form of ductal plate malformation and biliary adenofibroma, whose association with malignancy is rarely reported in the literature.
February 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29464866/biliary-stricture-due-to-a-migrated-suture-after-laparoscopic-distal-gastrectomy
#18
Takehiro Noji, Yo Kurashima, Yoshitsugu Nakanishi, Toshimichi Asano, Yuma Ebihara, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Tomoko Mitsuhashi, Satoshi Hirano
Benign biliary strictures have a broad spectrum of etiologies. There have been no reported cases, however, of a biliary stricture secondary to a migrated suture after laparoscopic distal gastrectomy (LDG). Here, we report one such case. The patient was a 60-year-old man who underwent LDG with Roux-en-Y reconstruction for early gastric cancer. Pathology revealed early cancer (T1N0M0) with a curative resection. Two years after LDG, the patient was found to have elevated hepatobiliary enzymes. After further workup, the new diagnosis was invasive cholangiocarcinoma (T2N0M0), and the patient underwent pancreaticoduodenectomy...
February 20, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29462482/a-randomized-phase-iii-trial-of-adjuvant-s-1-therapy-vs-observation-alone-in-resected-biliary-tract-cancer-japan-clinical-oncology-group-study-jcog1202-ascot
#19
Kohei Nakachi, Masaru Konishi, Masafumi Ikeda, Junki Mizusawa, Junko Eba, Takuji Okusaka, Hiroshi Ishii, Haruhiko Fukuda, Junji Furuse
No standard adjuvant treatment has been established for patients with curatively resected biliary tract cancer. S-1 has been reported to show promising efficacy with mild toxicity profiles in patients with advanced biliary tract cancer, and adjuvant S-1 therapy has been demonstrated to provide survival benefit in patients with resected gastric cancer and pancreatic cancer. The aim of this open-label, multicenter, randomized Phase III trial is to confirm that adjuvant chemotherapy with S-1 would prolong overall survival in patients with resected biliary tract cancer...
April 1, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29460642/novel-targeted-therapy-strategies-for-biliary-tract-cancers-and-hepatocellular-carcinoma
#20
Thomas T DeLeon, Daniel H Ahn, James M Bogenberger, Panos Z Anastasiadis, Mansi Arora, Ramesh K Ramanathan, Bashar A Aqel, George Vasmatzis, Mark J Truty, Rahmi Oklu, Tanios S Bekaii-Saab, Mitesh J Borad
Worldwide hepatobiliary cancers are the second leading cause of cancer related death. Despite their relevance, hepatobiliary cancers have a paucity of approved systemic therapy options. However, there are a number of emerging therapeutic biomarkers and therapeutic concepts that show promise. In hepatocellular carcinoma, nivolumab appears particularly promising and recently received US FDA approval. In intrahepatic cholangiocarcinoma, therapies targeting FGFR2 and IDH1 and immune checkpoint inhibitors are the furthest along and generating the most excitement...
March 2018: Future Oncology
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