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REM sleep without atonia

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https://www.readbyqxmd.com/read/27855735/pareidolias-in-rem-sleep-behavior-disorder-a-possible-predictive-marker-of-lewy-body-diseases
#1
Taeko Sasai-Sakuma, Yoshiyuki Nishio, Kayoko Yokoi, Etsuro Mori, Yuichi Inoue
STUDY OBJECTIVES: To investigate conditions and clinical significance of pareidolias in patients with idiopathic REM sleep behavior disorder (iRBD). METHODS: This cross-sectional study examined 202 patients with idiopathic rapid eye movement sleep behavior disorder (66.8±8.0 yr, 58 female) and 46 healthy control subjects (64.7±5.8 yr, 14 female). They underwent the Pareidolia test, a newly developed instrument for evoking pareidolias, video-polysomnography, olfactory tests, and Addenbrooke's cognitive examination - revised...
October 28, 2016: Sleep
https://www.readbyqxmd.com/read/27752878/treatment-of-rem-sleep-behavior-disorder
#2
Youngsin Jung, Erik K St Louis
REM sleep behavior disorder (RBD) is a common parasomnia disorder affecting between 1 and 7 % of community-dwelling adults, most frequently older adults. RBD is characterized by nocturnal complex motor behavior and polysomnographic REM sleep without atonia. RBD is strongly associated with synucleinopathy neurodegeneration. The approach to RBD management is currently twofold: symptomatic treatment to prevent injury and prognostic counseling and longitudinal follow-up surveillance for phenoconversion toward overt neurodegenerative disorders...
November 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27250807/sleep-pathology-in-creutzfeldt-jakob-disease
#3
Peter Kang, Gabriela S de Bruin, Leo H Wang, Beth A Ward, Beau M Ances, Miranda M Lim, Robert C Bucelli
STUDY OBJECTIVES: Associations between sleep and neurodegenerative diseases have become increasingly evident. This study aims to characterize the prevalence and type of sleep pathology in Creutzfeldt-Jakob disease (CJD), a rapidly progressive, fatal neurodegenerative disease. METHODS: In this observational cross-sectional cohort study, we performed a retrospective analysis of sleep signs and symptoms in a consecutive group of patients with definite CJD at a tertiary care medical center (n = 28)...
2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27245317/structural-brain-alterations-associated-with-rapid-eye-movement-sleep-behavior-disorder-in-parkinson-s-disease
#4
Soufiane Boucetta, Ali Salimi, Mahsa Dadar, Barbara E Jones, D Louis Collins, Thien Thanh Dang-Vu
Characterized by dream-enactment motor manifestations arising from rapid eye movement (REM) sleep, REM sleep behavior disorder (RBD) is frequently encountered in Parkinson's disease (PD). Yet the specific neurostructural changes associated with RBD in PD patients remain to be revealed by neuroimaging. Here we identified such neurostructural alterations by comparing large samples of magnetic resonance imaging (MRI) scans in 69 PD patients with probable RBD, 240 patients without RBD and 138 healthy controls, using deformation-based morphometry (p < 0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27186147/neurophysiological-basis-of-rapid-eye-movement-sleep-behavior-disorder-informing-future-drug-development
#5
REVIEW
Poul Jennum, Julie Ae Christensen, Marielle Zoetmulder
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by a history of recurrent nocturnal dream enactment behavior and loss of skeletal muscle atonia and increased phasic muscle activity during REM sleep: REM sleep without atonia. RBD and associated comorbidities have recently been identified as one of the most specific and potentially sensitive risk factors for later development of any of the alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and other atypical parkinsonian syndromes...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27108917/rem-sleep-without-atonia-in-middle-aged-and-older-psychiatric-patients-and-lewy-body-disease-a-case-series
#6
Hiroshige Fujishiro, Masato Okuda, Kunihiro Iwamoto, Seiko Miyata, Hironao Otake, Akiko Noda, Shuji Iritani, Norio Ozaki
OBJECTIVE: Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with Lewy body disease, narcolepsy, or depression. In contrast, the relationship between REM sleep without atonia (RWA), which is a hallmark of RBD on polysomnography, and clinical characteristics remains unclear. The purpose of this study is to investigate the clinical features of psychiatric patients exhibiting RWA and its relevance to Lewy body disease. METHODS: Of 55 consecutive patients who underwent polysomnography at the psychiatric ward, 25 patients with sleep apnea syndrome were excluded, and 12 patients exhibiting RWA were identified...
April 24, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27027974/rem-sleep-behavior-disorder-and-periodic-leg-movements-during-sleep-in-als
#7
D Lo Coco, M Puligheddu, P Mattaliano, P Congiu, G Borghero, M L Fantini, V La Bella, R Ferri
OBJECTIVE: To assess sleep characteristics and the occurrence of abnormal muscle activity during sleep, such as REM sleep without atonia (RSWA), REM sleep behavior disorder (RBD), and periodic leg movements during sleep (PLMS), in patients with amyotrophic lateral sclerosis (ALS). METHODS: A total of 41 patients with ALS and 26 healthy subjects were submitted to clinical interview and overnight video-polysomnography. RESULTS: A total of 22 patients with ALS (53...
March 29, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/26857056/does-postural-rigidity-decrease-during-rem-sleep-without-atonia-in-parkinson-disease
#8
Dario Arnaldi, Alice Latimier, Smaranda Leu-Semenescu, Fabrizio De Carli, Marie Vidailhet, Isabelle Arnulf
STUDY OBJECTIVES: Rigidity is a muscle hypertonia typical of Parkinson disease (PD), whereas rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormally increased muscle tone during REM sleep (REM sleep without atonia) and enacting dream behaviors. Because movements are not bradykinetic during RBD in patients with PD, we investigated whether the background, wake postural rigidity is attenuated during REM sleep without atonia, in absence of movement. METHODS: The amplitude of levator menti (postural muscle) electromyographic activity during relaxed evening wakefulness (considered as reference) and sleep (N2, N3, atonic REM sleep, and quiet REM sleep without atonia) was measured in 20 patients with PD (with and without RBD), 10 patients with idiopathic RBD patients and 10 healthy subjects...
2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26857053/an-open-labeled-trial-of-ramelteon-in-idiopathic-rapid-eye-movement-sleep-behavior-disorder
#9
Yuichi Esaki, Tsuyoshi Kitajima, Shigefumi Koike, Hiroshige Fujishiro, Yasuyo Iwata, Akiko Tsuchiya, Marina Hirose, Nakao Iwata
STUDY OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by REM sleep without atonia and elaborate motor activity in association with dream mentation. The melatonin receptor agonist ramelteon has been documented as being effective in two patients with secondary RBD. However, there are no reports on ramelteon treatment for idiopathic RBD. METHODS: In an open-labeled trial, we treated 12 consecutive patients with idiopathic RBD for at least 4 w with 8 mg ramelteon given within 30 min before bedtime...
May 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26763676/wilson-s-disease-with-and-without-rapid-eye-movement-sleep-behavior-disorder-compared-to-healthy-matched-controls
#10
Gotthard G Tribl, Mateus C Trindade, Thais Bittencourt, Geraldo Lorenzi-Filho, Rosana Cardoso Alves, Daniel Ciampi de Andrade, Erich T Fonoff, Edson Bor-Seng-Shu, Alexandre A Machado, Carlos H Schenck, Manoel J Teixeira, Egberto R Barbosa
OBJECTIVE: Quantitative data are reported on rapid eye movement (REM) sleep behavior disorder (RBD) in a cohort of predominantly neurological Wilson's disease (WD). METHODS: A total of 41 patients with WD and 41 healthy, age- and gender-matched controls were studied by conducting face-to-face interviews, neurological and clinical examinations, laboratory tests, and WD- and RBD-specific scales. Video-polysomnography and quantification of REM sleep without atonia (RWA) were conducted in 35 patients and 41 controls...
January 2016: Sleep Medicine
https://www.readbyqxmd.com/read/26737659/quantification-of-muscle-activity-during-sleep-for-patients-with-neurodegenerative-diseases
#11
Umaer Hanif, Lotte Trap, Poul Jennum, Marielle Zoetmulder, Helge B D Sorensen
Idiopathic REM sleep behavior disorder (iRBD) is a very strong predictor for later development of Parkinson's disease (PD), and is characterized by REM sleep without atonia (RSWA), resulting in increased muscle activity during REM sleep. Abundant studies have shown the loss of atonia during REM sleep, but our aim was to investigate whether iRBD and PD patients have increased muscle activity in both REM and NREM sleep compared to healthy controls. This was achieved by developing a semi-automatic algorithm for quantification of mean muscle activity per second during all sleep stages for the enrolled patients...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26736335/eeg-recordings-as-a-source-for-the-detection-of-irbd
#12
Sissel Bisgaard, Bolette Duun-Christensen, Lykke Kempfner, Helge B D Sorensen, Poul Jennum
The purpose of this pilot study was to develop a supportive algorithm for the detection of idiopathic Rapid Eye-Movement (REM) sleep Behaviour Disorder (iRBD) from EEG recordings. iRBD is defined as REM sleep without atonia with no current sign of neurodegenerative disease, and is one of the earliest known biomarkers of Parkinson's Disease (PD). It is currently diagnosed by polysomnography (PSG), primarily based on EMG recordings during REM sleep. The algorithm was developed using data collected from 42 control subjects and 34 iRBD subjects...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26611948/neuroimaging-evident-lesional-pathology-associated-with-rem-sleep-behavior-disorder
#13
Stuart J McCarter, Maja Tippmann-Peikert, David J Sandness, Eoin P Flanagan, Kejal Kantarci, Bradley F Boeve, Michael H Silber, Erik K St Louis
BACKGROUND/RATIONALE: Rapid eye movement (REM) sleep behavior disorder (RBD) is a potentially injurious parasomnia characterized by dream enactment behavior and polysomnographic REM sleep without atonia (RSWA). Recently, RBD not only has been shown to be strongly associated with synucleinopathy neurodegeneration but has also been rarely reported to be associated with structural lesions involving the brainstem or limbic system. The aim of this study was to describe the clinical, neuroimaging, and outcome characteristics in a case series of patients with lesional RBD...
December 2015: Sleep Medicine
https://www.readbyqxmd.com/read/26446247/the-prevalence-and-characteristics-of-rem-sleep-without-atonia-rswa-in-patients-taking-antidepressants
#14
Kenneth Lee, Kelly Baron, Rodolfo Soca, Hrayr Attarian
STUDY OBJECTIVES: The association of REM sleep without atonia (RSWA) as well as REM sleep behavior disorder (RBD) with the intake of selective serotonin reuptake inhibitors (SSRI) and selective norepinephrine reuptake inhibitors (SNRI) is well established. Our study objective was to determine the prevalence of RSWA and RBD among a group of sleep center patients taking SSRI and SNRI. METHODS: A retrospective chart review was done at our tertiary sleep center, and 10,746 consecutive records from October 1, 2007, through October 31, 2013, were searched for SSRI and SNRI names using the Sleep Cataloguer Software...
March 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26359123/nrem-related-parasomnias-in-machado-joseph-disease-clinical-and-polysomnographic-evaluation
#15
Giselle Melo Fontes Silva, José Luiz Pedroso, Diogo Fernandes Dos Santos, Pedro Braga-Neto, Lucila Bizari Fernandes Do Prado, Luciane Bizari Coin De Carvalho, Orlando G P Barsottini, Gilmar Fernandes Do Prado
Spinocerebellar ataxias (SCA) are autosomal dominant neurodegenerative disorders that affect the cerebellum and its connections, and have a marked clinical and genetic variability. Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3)--MJD/SCA3--is the most common SCA worldwide. MJD/SCA3 is characterized classically by progressive ataxia and variable other motor and non-motor symptoms. Sleep disorders are common, and include rapid eye movement (REM) sleep behaviour disorder (RBD), restless legs syndrome (RLS), insomnia, excessive daytime sleepiness, excessive fragmentary myoclonus and sleep apnea...
February 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/26322978/polysomnographic-assessment-of-sleep-comorbidities-in-drug-na%C3%A3-ve-narcolepsy-spectrum-disorders-a-japanese-cross-sectional-study
#16
Taeko Sasai-Sakuma, Akihiko Kinoshita, Yuichi Inoue
This is a large cross-sectional study which aimed to investigate comorbidity rate, degree of sleep-related breathing disorder, polysomnigraphically diagnosible rapid eye movement sleep behavior disorder/rapid eye movement sleep without atonia and periodic limb movements during sleep in Japanese drug-naïve patients with narcolepsy-spectrum disorders. A total of 158 consecutive drug naïve patients with narcolepsy with cataplexy, 295 patients with narcolepsy without cataplexy and 395 patients with idiopathic hypersomnia without long sleep time were enrolled...
2015: PloS One
https://www.readbyqxmd.com/read/26241245/what-does-one-sleep-onset-rem-period%C3%A2-during-either-nocturnal-polysomnography-or-multiple-sleep-latency-test%C3%A2-mean-in-differential-diagnosis-of-central-hypersomnias
#17
Melda Bozluolcay, Mecbure Nalbantoglu, Gulcin Benbir Senel, Derya Karadeniz
PURPOSE: The differentiation of narcolepsy without cataplexy from idiopathic hypersomnia is based on the number of sleep-onset rapid eye movement periods (SOREMPs) observed by multiple sleep latency test (MSLT) and nocturnal polysomnography. The main aim of this study was to investigate the utility of SOREMP in differential diagnosis of central hypersomnias. METHODS: The authors retrospectively evaluated consecutive 101 patients with a normal polysomnography other than the presence of SOREMP and/or REM without atonia and a latency of ≤8 minutes in MSLT...
August 2015: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/26156949/long-term-follow-up-investigation-of-isolated-rapid-eye-movement-sleep-without-atonia-without-rapid-eye-movement-sleep-behavior-disorder-a-pilot-study
#18
Ambra Stefani, David Gabelia, Birgit Högl, Thomas Mitterling, Philipp Mahlknecht, Heike Stockner, Werner Poewe, Birgit Frauscher
STUDY OBJECTIVES: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a harbinger of synuclein-mediated neurodegenerative diseases. It is unknown if this also applies to isolated REM sleep without atonia (RWA). We performed a long-term follow-up investigation of subjects with isolated RWA. METHODS: Participants were recruited from 50 subjects with isolated RWA who were identified at the sleep laboratory of the Department of Neurology at the Medical University of Innsbruck between 2003 and 2005...
November 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26122167/human-rem-sleep-influence-on-feeding-behaviour-with-clinical-implications
#19
REVIEW
James A Horne
Rapid eye movement (REM) sleep shares many underlying mechanisms with wakefulness, to a much greater extent than does non-REM, especially those relating to feeding behaviours, appetite, curiosity, exploratory (locomotor) activities, as well as aspects of emotions, particularly 'fear extinction'. REM is most evident in infancy, thereafter declining in what seems to be a dispensable manner that largely reciprocates increasing wakefulness. However, human adults retain more REM than do other mammals, where for us it is most abundant during our usual final REM period (fREMP) of the night, nearing wakefulness...
August 2015: Sleep Medicine
https://www.readbyqxmd.com/read/26107678/insulinoma-masquerading-as-rapid-eye-movement-sleep-behavior-disorder-case-series-and-literature-review
#20
REVIEW
Keisuke Suzuki, Akiko Kawasaki, Masayuki Miyamoto, Tomoyuki Miyamoto, Takashi Kanbayashi, Masatoshi Sato, Tetsuo Shimizu, Koichi Hirata
Insulinoma is a rare endocrine tumor that can cause a wide variety of symptoms, including abnormal nocturnal behavior. We report on 3 patients with insulinoma who presented with abnormal nocturnal behavior and injury during sleep, which simulated rapid eye movement (REM) sleep behavior disorder (RBD). In case 1, the fasting glucose level was 15  mg/dL, and insulin levels were elevated (15  μU/mL). In case 3, when the patient was transferred to the hospital because of a disturbance of consciousness, hypoglycemia (29  mg/dL) was detected...
June 2015: Medicine (Baltimore)
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