keyword
https://read.qxmd.com/read/38490134/sirt6-mediated-vascular-smooth-muscle-cells-senescence-participates-in-the-pathogenesis-of-abdominal-aortic-aneurysm
#1
JOURNAL ARTICLE
Le Yang, Xuejun Wu, Shuai Bian, Dongfang Zhao, Sheng Fang, Hai Yuan
BACKGROUND AND AIMS: In this study, we carried out a clinical sample study, and in vivo and in vitro studies to evaluate the effect of SIRT6 and SIRT6-mediated vascular smooth muscle senescence on the development of abdominal aortic aneurysm (AAA). METHOD AND RESULTS: AAA specimen showed an increased P16, P21 level and a decreased SIRT6 level compared with control aorta. Time curve study of Ang II infusion AAA model showed similar P16, P21 and SIRT6 changes at the early phase of AAA induction...
February 24, 2024: Atherosclerosis
https://read.qxmd.com/read/38487044/female-specific-considerations-in-aortic-health-and-disease
#2
REVIEW
Rebecca Crosier, Maria Agustina Lopez Laporte, Rudy R Unni, Thais Coutinho
The aorta plays a central role in the modulation of blood flow to supply end organs and to optimize the workload of the left ventricle. The constant interaction of the arterial wall with protective and deleterious circulating factors, and the cumulative exposure to ventriculoarterial pulsatile load, with its associated intimal-medial changes, are important players in the complex process of vascular aging. Vascular aging is also modulated by biomolecular processes such as oxidative stress, genomic instability, and cellular senescence...
February 2024: CJC open
https://read.qxmd.com/read/38487034/acute-dissection-of-a-syphilitic-saccular-aneurysm-of-the-ascending-aorta-and-arch-in-a-hypertensive-patient-a-rare-phenomenon
#3
Hubert Daisley, Dennecia George, Johann Daisley
We report the case of a 77-year-old male who suffered from hypertension and died suddenly. At autopsy, he was found to have hypertensive cardiomegaly and a dissecting syphilitic saccular aneurysm of the ascending aorta and arch with tamponade. Chronic aortic regurgitation, which is often seen in syphilitic aortitis, produces an additive effect to the concentric left ventricular hypertrophy seen in hypertension.
2024: Autopsy & Case Reports
https://read.qxmd.com/read/38483247/multimodality-imaging-features-of-immunoglobulin-g4-related-vessel-involvement
#4
JOURNAL ARTICLE
Aileen O'Shea, Rory K Crotty, Mangun Kaur Randhawa, George Oliveira, Cory A Perugino, John H Stone, Mukesh G Harisinghani, Zachary S Wallace, Sandeep S Hedgire
Immunoglobulin 4 (IgG4)-related disease is a chronic immune-mediated fibroinflammatory disorder. Involvement of the vascular system, including large- and medium-sized vessels, is increasingly recognized. The varied appearances of vascular involvement reflect the sequela of chronic inflammation and fibrosis and can include aortitis and periaortitis with resultant complications such as aneurysm formation and dissection. A diagnosis of IgG4-related large vessel involvement should be considered when there is known or suspected IgG4-related disease elsewhere...
April 2024: Radiology. Cardiothoracic imaging
https://read.qxmd.com/read/38478992/-development-techniques-and-utility-of-experimental-animal-models-of-thoracic-and-abdominal-aortic-aneurysms
#5
JOURNAL ARTICLE
Carlos C Bravo-Reyna, Jacqueline Mejía-Cervantes, Ana T Verduzco-Vázquez, Cristopher Sánchez-Rodríguez, Leonardo Cuervo-Vargas, Luis A Medina-Velázquez, Víctor Gómez-Vergara, Carlos A Hinojosa, Javier E Anaya-Ayala
Aneurysms are clinical entities that can develop and affect human aorta; and although in most cases they have an asymptomatic course, these pathological dilatations can lead to a lethal outcome when rupture occurs, thus the establishment of predictors is crucial for death prevention. Essential events that take place in the vessel wall have been identified and described, such as inflammation, proteolysis, smooth muscle cell apoptosis, angiogenesis, and vascular remodeling. Porcine and ovine models have been useful for the development and evaluation of endovascular devices of the aorta...
March 13, 2024: Archivos de Cardiología de México
https://read.qxmd.com/read/38476969/investigating-the-influence-of-collagen-cross-linking-on-mechanical-properties-of-thoracic-aortic-tissue
#6
JOURNAL ARTICLE
Chung Won Lee, Chiseung Lee, Seungik Baek, Emrah Akkoyun, Dongman Ryu
Vascular diseases, such as abdominal aortic aneurysms, are associated with tissue degeneration of the aortic wall, resulting in variations in mechanical properties, such as tissue ultimate stress and a high slope. Variations in the mechanical properties of tissues may be associated with an increase in the number of collagen cross-links. Understanding the effect of collagen cross-linking on tissue mechanical properties can significantly aid in predicting diseased aortic tissue rupture and improve the clarity of decisions regarding surgical procedures...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38476287/tertiary-syphilis-and-cardiovascular-disease-the-united-triad-case-report
#7
Taha Berhil, Fatima Zohra Radi, Badre El Boussaadani, Zainab Raissouni
BACKGROUND: Syphilis, owing to its natural course, can lead to long-term damage to the aortic valve, such as insufficiency and rarely stenosis, ostial coronary stenosis, and syphilitic aortitis. Cardiovascular involvement alongside neurological involvement dominates the prognosis. This should no longer be seen, thanks to awareness and prevention programmes, medical treatment, and antibiotics. CASE SUMMARY: We report a case of a 54-year-old chronic smoker with no previous history, admitted for respiratory distress amid an impaired general condition...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38474394/current-insights-into-tissue-injury-of-giant-cell-arteritis-from-acute-inflammatory-responses-towards-inappropriate-tissue-remodeling
#8
REVIEW
Dimitris Anastasios Palamidas, Loukas Chatzis, Maria Papadaki, Ilias Gissis, Konstantinos Kambas, Evangelos Andreakos, Andreas V Goules, Athanasios G Tzioufas
Giant cell arteritis (GCA) is an autoimmune disease affecting large vessels in patients over 50 years old. It is an exemplary model of a classic inflammatory disorder with IL-6 playing the leading role. The main comorbidities that may appear acutely or chronically are vascular occlusion leading to blindness and thoracic aorta aneurysm formation, respectively. The tissue inflammatory bulk is expressed as acute or chronic delayed-type hypersensitivity reactions, the latter being apparent by giant cell formation...
February 29, 2024: Cells
https://read.qxmd.com/read/38471650/outcomes-for-patients-undergoing-transcatheter-aortic-valve-replacement-with-ascending-aorta-dilation
#9
JOURNAL ARTICLE
Dejing Feng, Jie Zhao, Guannan Niu, Yuxuan Zhang, Can Wang, Yang Chen, Zheng Zhou, Hongliang Zhang, Zhenyan Zhao, Yunqing Ye, Zhe Li, Haiyan Xu, Moyang Wang, Yongjian Wu
BACKGROUND: We aim to compare the short and long-term outcomes for aortic stenosis (AS) patients undergone TAVR with and without ascending aorta dilation (AAD). METHODS: Consecutive patients diagnosed with native severe AS who underwent TAVR from September 2012 to September 2021 were enrolled. They were stratified into the moderate/severe dilation group (greatest ascending aorta width ≥ 45 mm) and the non/mild dilation group. Survival outcomes were illustrated using Kaplan-Meier curves and evaluated with the log-rank test...
March 10, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38468329/evaluation-of-the-embopipe-flow-diverter-device-in-vivo-and-in-vitro-experiments
#10
JOURNAL ARTICLE
Yongnan Zhu, Fanyan Zeng, Jian Liu, Shiqing Mu, Xinjian Yang, Ying Zhang
BACKGROUND: Although flow diverter device (FDD) has brought revolutionized advances in endovascular treatment of intracranial aneurysms, it also presents considerable drawbacks as well, as the innovation for novel device has never stopped. This preclinical research aims to evaluate the safety and efficacy of a newly developed FDD, the EMBOPIPE, through in vivo and in vitro experiments. METHODS: Aneurysms were induced in 20 New Zealand white rabbits which were randomized to three follow-up groups according to the time elapsed after EMBOPIPE implantation (28, 90, and 180 days)...
March 12, 2024: Chinese Neurosurgical Journal
https://read.qxmd.com/read/38467550/pathogenetic-significance-of-long-non-coding-rnas-in-the-development-of-thoracic-and-abdominal-aortic-aneurysms
#11
REVIEW
Aksana N Kucher, Iuliia A Koroleva, Maria S Nazarenko
Aortic aneurysm (AA) is a life-threatening condition with a high prevalence and risk of severe complications. The aim of this review was to summarize the data on the role of long non-coding RNAs (lncRNAs) in the development of AAs of various location. Within less than a decade of studies on the role of lncRNAs in AA, using experimental and bioinformatic approaches, scientists have obtained the data confirming the involvement of these molecules in metabolic pathways and pathogenetic mechanisms critical for the aneurysm development...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38465173/motor-evoked-potential-monitoring-with-multi-train-electrical-stimulation-during-thoracoabdominal-aortic-aneurysm-surgery-a-case-report
#12
Takeo Yuno, Yusuke Nakade, Kenji Iino, Takumi Taniguchi, Hiroyasu Oe
Intraoperative motor-evoked potentials (MEPs) are measured for assessing motor function during surgery. MEP monitoring is often performed in thoracoabdominal aortic aneurysm (TAAA) surgery, but false positives are common and amplification methods are needed to obtain waveforms under severe conditions to assess proper spinal cord function. One method of amplitude amplification in transcranial-stimulated MEP monitoring is multitrain stimulation. There are few reports on multitrain-stimulated MEP monitoring for this surgery...
February 2024: Curēus
https://read.qxmd.com/read/38464889/open-repair-of-a-ruptured-abdominal-aorta-with-an-aortoiliac-vein-fistula-in-a-7-month-old-infant-and-review-of-the-literature
#13
JOURNAL ARTICLE
Olivia I Fuson, Kelsi Hirai, Devin R Halleran, Mubeen Jafri, Ashok Muralidaran, Amir Azarbal, Cherrie Z Abraham, Sherene Shalhub
Ruptured abdominal aortic aneurysms are extremely rare in the pediatric population. In this video case report, we describe the successful repair of a ruptured abdominal aortic aneurysm in a 7-month-old female infant.
April 2024: Journal of Vascular Surgery Cases and Innovative Techniques
https://read.qxmd.com/read/38464026/thymidine-phosphorylase-promotes-the-formation-of-abdominal-aortic-aneurysm-in-mice-fed-a-western-diet
#14
Liang Hong, Hong Yue, Dunpeng Cai, Autumn DeHart, Gretel Toloza-Alvarez, Lili Du, Xianwu Zhou, Xiaoping Fan, Huanlei Huang, Shiyou Chen, Shaik O Rahaman, Jian Zhuang, Wei Li
AIMS: The precise molecular drivers of abdominal aortic aneurysm (AAA) remain unclear. Thymidine phosphorylase (TYMP) contributes to increased platelet activation, thrombosis, and inflammation, all of which are key factors in AAA development. Additionally, TYMP suppresses the proliferation of vascular smooth muscle cells (VSMCs), which are central to the development and progression of AAA. We hypothesize that TYMP plays a key role in AAA development. METHODS AND RESULTS: We conducted a histological study using human AAA samples and normal abdominal aortas, revealing heightened levels of TYMP in human AAA vessel walls...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38463737/stop-exsanguination-by-inflation-management-of-aorta-esophageal-fistula-bleeding
#15
Kristina M Pagano, Alexander A Fokin, Michael Parra, Ivan Puente
Aortoesophageal fistula is rare and typically presents itself to the emergency department as Chiari's Triad of mid-thoracic pain, sentinel arterial hemorrhage, and exsanguination after a symptom-free interval. However, fatal bleeding may be the first and last presentation of an aortoesophageal fistula. When a patient experiences massive hematemesis without witnesses, EMS may assume that bleed is of a traumatic mechanism. We present a case of a 59-year-old male with no previous medical history who was transported to a trauma center unconscious and with massive bleeding of unknown origin...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38463128/intimomedial-mucoid-degeneration-resulting-in-a-dissecting-infrarenal-abdominal-aortic-aneurysm-in-a-young-middle-eastern-male-a-case-report
#16
Omar Hariri, Omar Al Laham, Lina Haffar, Mohammad Ghannam, Ammar Mohammad
INTRODUCTION AND IMPORTANCE: Intimomedial mucoid degeneration is a rare vascular disorder first depicted in 1977. It involves mucin deposition in arterial layers. This will cause elastic tissue degeneration and aneurysm formation. This pathology predominantly affects the aorta. However, it could involve other smaller vessels. Surgical treatment could become complicated by a bleeding diathesis. Therefore, a precise surgical technique is necessary to avoid the ensuing complications. CASE PRESENTATION: We present the case of a previously healthy 27-year-old Middle Eastern male who presented to our surgical clinic following the incidental discovery of an infrarenal abdominal aortic aneurysm following a blunt trauma to the left flank incurred during a fall...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38461960/the-potential-involvement-of-glycocalyx-disruption-in-abdominal-aortic-aneurysm-pathogenesis
#17
REVIEW
Bibi Rabia, Shivshankar Thanigaimani, Jonathan Golledge
BACKGROUND: Abdominal aortic aneurysm (AAA) is a weakening and expansion of the abdominal aorta. Currently, there is no drug treatment to limit AAA growth. The glycocalyx (GC) is the outermost layer of the cell surface, mainly composed of glycosaminoglycans (GAGs) and proteoglycans. OBJECTIVE: The aim of this review was to identify a potential relationship between GC disruption and AAA pathogenesis. METHODS: A narrative review of relevant published research was conducted...
March 8, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38461759/antisense-oligonucleotide-targeting-hepatic-serum-amyloid-a-limits-the-progression-of-angiotensin-ii-induced-abdominal-aortic-aneurysm-formation
#18
JOURNAL ARTICLE
Preetha Shridas, Ailing Ji, Andrea C Trumbauer, Victoria P Noffsinger, Luke W Meredith, Frederick C de Beer, Adam E Mullick, Nancy R Webb, Dennis G Karounos, Lisa R Tannock
BACKGROUND AND AIMS: Obesity increases the risk for abdominal aortic aneurysms (AAA) in humans and enhances angiotensin II (AngII)-induced AAA formation in C57BL/6 mice. We reported that deficiency of Serum Amyloid A (SAA) significantly reduces AngII-induced inflammation and AAA in both hyperlipidemic apoE-deficient and obese C57BL/6 mice. The aim of this study is to investigate whether SAA plays a role in the progression of early AAA in obese C57BL/6 mice. METHODS: Male C57BL/6J mice were fed a high-fat diet (60% kcal as fat) throughout the study...
February 26, 2024: Atherosclerosis
https://read.qxmd.com/read/38461168/in-vivo-phenotypic-vascular-dysfunction-extends-beyond-the-aorta-in-a-mouse-model-for-fibrillin-1-fbn1-mutation
#19
JOURNAL ARTICLE
T Curry, M E Barrameda, T Currier Thomas, M Esfandiarei
In individuals with Marfan Syndrome (MFS), fibrillin-1 gene (FBN1) mutations can lead to vascular wall weakening and dysfunction. The experimental mouse model of MFS (Fbn1C1041G/+ ) has been advantageous in investigating MFS-associated life-threatening aortic aneurysms. It is well established that the MFS mouse model exhibits an accelerated-aging phenotype in elastic organs like the aorta, lung, and skin. However, the impact of Fbn1 mutations on the in vivo function and structure of various artery types with the consideration of sex and age, has not been adequately explored in real-time and a clinically relevant context...
March 9, 2024: Scientific Reports
https://read.qxmd.com/read/38460757/screening-men-and-women-above-the-age-of-50-years-for-abdominal-aortic-aneurysm-a-pilot-study-in-an-upper-middle-income-country
#20
JOURNAL ARTICLE
Igor Koncar, Aleksa Jovanovic, Ognjen Kostic, Andrija Roganovic, Djurdjija Jelicic, Stefan Ducic, Lazar Davidovic
OBJECTIVE: Screening for abdominal aortic aneurysm (AAA) is recommended in high risk populations based on local conditions. Differences in lifestyle and risk factors between countries with different income status make risk stratification based on geographic location necessary. The majority of epidemiological studies on AAA have reported data from high income countries. The aim of this study was to explore the prevalence and risk factors for AAA in an upper middle income country in Eastern Europe...
March 7, 2024: European Journal of Vascular and Endovascular Surgery
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