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Abdur Rahman, Khalid M Khan, Muddanna S Rao
Lead (Pb) is a neurotoxic heavy metal, but the mechanism of its neurotoxicity is not clearly understood. Expression of metallothioneins (MTs) is induced in response to heavy metal exposure as a protective mechanism against heavy metal toxicity. There are several isoforms of MTs (MT-1 to 4), of which MT-3 is the neuron specific isoform, which also has neurite growth inhibitory effects. Whereas, the induction of MT-1 and 2 in response to Pb has been reported, the effect of Pb on the expression of MT-3 in the brain has not been documented...
February 13, 2018: Neurotoxicology
Leslie Raphael de Moura Ferraz, Alinne Élida Gonçalves Alves, Débora Dolores Souza da Silva Nascimento, Isabela Araújo E Amariz, Aline Silva Ferreira, Salvana Priscylla Manso Costa, Larissa Araújo Rolim, Ádley Antonini Neves de Lima, Pedro José Rolim Neto
Caused by Trypanosoma cruzi, Chagas disease is responsible for public health problems greater in magnitude than those attributed to malaria, schistosomiasis, or leishmaniasis. A factor in the socioeconomic development of poor countries, Chagas disease can cause death due to a high parasitic burden during its acute phase due and irreversible damage in organs such as the heart, esophagus, and colon during its chronic phase, even when the number of parasites is minimal. For treating Chagas disease, benznidazole (BNZ) remains the drug of choice and, in Latin America, the only drug on the market for treating the disease...
February 13, 2018: Acta Tropica
Yoo Jin Lee, Jin Young Yoon, Jae Jun Park, Soo Jung Park, Jie-Hyun Kim, Young Hoon Youn, Tae Il Kim, Hyojin Park, Won Ho Kim, Jae Hee Cheon
BACKGROUND AND AIMS: Although colonic perforation is a dreadful adverse event associated with stent placement, data on this topic are sparse. We aimed to investigate the clinical outcomes of colonic perforation and factors related with its occurrence in patients who receiving self-expanding metal stents (SEMSs) for malignant colorectal obstruction. METHODS: We retrospectively reviewed the data of 474 patients with malignant colorectal obstruction who received endoscopic SEMS insertion from April 2004 to May 2011 in the Severance and Gangnam Severance Hospital...
February 13, 2018: Gastrointestinal Endoscopy
Xinyu Yang, Shuai Yuan, Lanfang Zou, Hannah Drake, Yingmu Zhang, Junsheng Qin, Ali Alsalme, Hongcai Zhou
Epitaxial growth of MOF-on-MOF composite is an evolving research topic. In current methods, the core-shell MOFs are synthesized via a stepwise strategy which involves growing the shell-MOFs on top of the preformed core-MOFs with matched lattice parameters. However, the inconvenient stepwise synthesis and the strict lattice-matching requirement have limited the development of core-shell MOFs. Herein, we demonstrate that hybrid core-shell MOFs with mismatching lattices can be synthesized under the guidance of nucleation kinetics...
February 16, 2018: Angewandte Chemie
Varahenage R Perera, John D Lapek, Gerald L Newton, David J Gonzalez, Kit Pogliano
Bacillithiol is a low molecular weight thiol found in Firmicutes that is analogous to glutathione, which is absent in these bacteria. Bacillithiol transferases catalyze the transfer of bacillithiol to various substrates. The S-transferase-like (STL) superfamily contains over 30,000 putative members, including bacillithiol transferases. Proteins in this family are extremely divergent and are related by structural rather than sequence similarity, leaving it unclear if all share the same biochemical activity. Bacillus subtilis encodes eight predicted STL superfamily members, only one of which has been shown to be a bacillithiol transferase...
2018: PloS One
Tadele Melese, Dereje Habte, Billy M Tsima, Keitshokile Dintle Mogobe, Mercy N Nassali
BACKGROUND: Post abortion complications are the third leading cause of maternal death after hemorrhage and hypertension in Botswana where abortion is not legalized. This study aimed at assessing the management of post abortion complications in Botswana. METHODS: A retrospective study was conducted at four hospitals in Botswana in 2014. Socio-demographic, patient management and outcomes data were extracted from patients' medical records. Descriptive statistics and chi-square test were used to analyze and present the data...
2018: PloS One
Gal Y Kreitman, Ryan J Elias, David W Jeffery, Gavin L Sacks
Volatile sulfur compounds (VSCs), particularly low molecular weight sulfhydryls like hydrogen sulfide (H 2 S) and methanethiol (MeSH), are often observed in wines with sulfurous off-aromas. Recent work has shown both H 2 S and MeSH can increase up to a few µM (> 40 µg/L) during anoxic storage, but the identity of the latent sources of these sulfhydryls is still disputed. This review critically evaluates the latent precursors and pathways likely to be responsible for the loss and formation of these sulfhydryls during wine storage based on the existing enology literature as well as studies from food chemistry, geochemistry, biochemistry, and synthetic chemistry...
February 16, 2018: Critical Reviews in Food Science and Nutrition
Mathew J Cherukara, Daniel S Schulman, Kiran Sasikumar, Andrew Joseph Arnold, Henry Chan, Sridhar Sadasivam, Joerg Maser, Wonsuk Cha, Saptarshi Das, Subramanian K R S Sankaranarayanan, Ross J Harder
Emerging 2-D materials such as transition metal dichalcogenides show great promise as viable alternatives for semiconductor and optoelectronic devices that progress beyond silicon. Performance variability, reliability and stochasticity in the measured transport properties represent some of the major challenges in such devices. Native strain arising from interfacial effects due to the presence of a substrate is believed to be a major contributing factor. A full three-dimensional (3-D) mapping of such native nanoscopic strain over micron length scales is highly desirable to gain a fundamental understanding of interfacial effects but has largely remained elusive...
February 16, 2018: Nano Letters
Jie Yang, Fuping Jiang, Chuanxin Ma, Yu-Kui Rui, Mengmeng Rui, Adeel Muhammad, Weidong Cao, Baoshan Xing
Due to the rapid development of nanotechnology, metal-based nanoparticles (NPs) are inadvertently released into environment and may pose a potential threat to ecosystem. However, information for food quality and safety in NP treated crops is limited. In the present study, wheat (Triticum aestivum L.) was grown in different concentrations of Ag NP amended soil (20, 200, and 2000 mg•kg-1) for four months. At harvest, physiological parameters, Ag and micronutrients (Fe, Cu, and Zn) content, as well as amino acid and protein contents were measured...
February 16, 2018: Journal of Agricultural and Food Chemistry
Anthony K Cheetham, G Kieslich, H H-M Yeung
The evolution of metal-organic frameworks (MOFs) has been one of the most exciting aspects of materials chemistry over the last 20 years. In this Account, we discuss the development during this period in our understanding of the factors that control the crystallization of MOFs from solution. Both classical porous MOFs and dense MOF phases are considered. This is an opportune time at which to examine this complex area because the experimental tools now available to interrogate crystallization processes have matured significantly in the last 5 years, particularly with the use of in situ synchrotron X-ray diffraction...
February 16, 2018: Accounts of Chemical Research
Jan Hynek, Petr Brázda, Jan Rohlíček, Michael G S Londesborough, Jan Demel
Metal-organic frameworks (MOFs) are a chemically and topologically diverse family of materials composed of inorganic nodes and organic linkers bound together by coordination bonds. In this contribution we present two significant innovations in this field. The first is the use of a new coordination group in phenylene-1,4-bis(methylphosphinic acid) (PBPA), a phosphinic acid analogue of commonly-used terephtalic acid. We show that the use of this new linker group leads to the formation of a hydrothermally stable permanently porous MOF structure...
February 16, 2018: Angewandte Chemie
Wei Zhang, Jun Lu, Xiaonan Gao, Ping Li, Wen Zhang, Yu Ma, Hui Wang, Bo Tang
In photodynamic therapy (PDT), the level of reactive oxygen species (ROS) produced in the cell directly determines therapeutic effect. Therefore, the development of photosensitizers combining the ability of reducing GSH levels through synergistically improving ROS concentration to strengthen the efficacy of PDT for tumor is important. We report a nano-metal-organic framework based on Cu (II) as active center for PDT. This MOF-2 is readily uptaken by breast cancer cells, and high-level ROS is generated under light irradiation...
February 16, 2018: Angewandte Chemie
Murilo Matias, Marcos Roberto de Freitas, Karina Maria Salvatore de Freitas, Guilherme Janson, Rodrigo Hitoshi Higa, Manoela Fávaro Francisconi
Coated archwires and ceramic brackets have been developed to improve facial esthetics during orthodontic treatment. However, their mechanical behavior has been shown to be different from metallic archwires and brackets. Therefore, the aim of this study was to compare the deflection forces in coated nickel-titanium (NiTi) and esthetic archwires combined with ceramic brackets. Material and Methods Non-coated NiTi (NC), rhodium coated NiTi (RC), teflon coated NiTi (TC), epoxy coated NiTi (EC), fiber-reinforced polymer (FRP), and the three different conventional brackets metal-insert polycrystalline ceramic (MI-PC), polycrystalline ceramic (PC) and monocrystalline ceramic (MC) were used...
2018: Journal of Applied Oral Science: Revista FOB
Ji-Min Yang, Rong-Jian Ying, Chun-Xiang Han, Qi-Tu Hu, Hui-Min Xu, Jian-Hui Li, Qiang Wang, Wei Zhang
Herein, we report the synthesis and characterization of Ce(iii)-doped UiO-66 nanocrystals, revealing their potential to efficiently remove organic dyes such as methylene blue (MB), methyl orange (MO), Congo red (CR), and acid chrome blue K (AC) from aqueous solutions. Specifically, the room-temperature adsorption capacities of Ce(iii)-doped UiO-66 equaled 145.3 (MB), 639.6 (MO), and 826.7 (CR) mg g -1 , exceeding those reported for pristine UiO-66 by 490, 270, and 70%, respectively. The above behavior was rationalized based on zeta potential and adsorption isotherm investigations, which revealed that Ce(iii) doping increases the number of adsorption sites and promotes π-π interactions between the adsorbent and the adsorbate, thus improving the adsorption capacity for cationic and anionic dyes and overriding the effect of electrostatic interactions...
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Qian Chen, Yulin Huang, Xiaofeng Wang, Jiawei Wu, Guodian Yu
A highly efficient sulfonylation of thiols has been achieved through the metal-free NaI/TBHP-mediated cross-coupling of sulfonyl hydrazides and thiols at room temperature. This method provides a convenient and practical route to thiosulfonates in 84-99% yields (39 examples) with wide functional group compatibility.
February 16, 2018: Organic & Biomolecular Chemistry
Pengcheng Wu, Xianyin Song, Shuyao Si, Zunjian Ke, Cheng Li, Wenqing Li, Xiangheng Xiao, Chang-Zong Jiang
Metal-oxide semiconductor TiO2 shows enormous potential in the field of photoelectric detection, however, the only UV-light absorption always restricts its widespread application. It is considered that nitrogen doping can improve the visible light absorption of TiO2, but the effect of traditional chemical doping is far from being used for visible light detection. Herein we dramatically broadened the absorption spectrum of TiO2 nanowire (NW) by nitrogen ions implantation and applied the N-doped single TiO2 NW to visible light detection for the first time...
February 16, 2018: Nanotechnology
Sibo Lin, Timothy M Swager
Formic acid is corrosive, and a sensitive and selective sensor could be useful in industrial, medical, and environmental settings. We present a chemiresistor for detection of formic acid composed of single-walled carbon nanotubes (CNTs) and nickel bis(ortho-diiminosemiquinonate) (1), a planar metal complex that can act as a ditopic hydrogen-bonding selector. Formic acid is detected in concentrations as low as 83 ppb. The resistance of the material decreases on exposure to formic acid, but slightly increases on exposure to acetic acid...
February 16, 2018: ACS Sensors
Mitsuki Hori, Jing-Dong Guo, Tomoyuki Yanagi, Keisuke Nogi, Takahiro Sasamori, Hideki Yorimitsu
Metal-free dehydrogenative coupling of aryliodanes with phenols to afford 2-hydroxy-2'-iodobiaryls has been developed. This reaction proceeds via ligand exchange on the hypervalent iodine atom, followed by [3,3] sigmatropic rearrangement, to realize exclusive regioselectivity. This coupling, in combination with in situ oxidation by mCPBA, facilitates the convenient conversion of iodoarenes into the desired biaryls. The obtained biaryls have convertible iodo and hydroxy groups in close proximity, and are thus synthetically useful, as exemplified by the controlled syntheses of π-expanded furans and a substituted [5] helicene...
February 16, 2018: Angewandte Chemie
Irán Rojas-León, Hazem Alnasr, Klaus Jurkschat, Maria G Vasquez-Ríos, Irán F Hernández-Ahuactzi, Herbert Höpfl
Di- and trinuclear organometallic tin (IV) complexes, in which the metal atoms are separated by large aromatic connectors, are useful building blocks for self-assembly. This is demonstrated by the preparation of [1+1], [2+2] and [2+3] macrocyclic and cage-type structures in combination with organic aromatic dicarboxylates. The linkage of the metal atoms by organic binders and the option of varying the number of reactive M-X sites generate versatile building blocks enabling molecular tectonics instead of the node-based strategy generally employed in metallo-supramolecular self-assembly...
February 16, 2018: Chemistry: a European Journal
Yuanyuan Wen, Wei Meng, Chen Li, Lei Dai, Zhangxing He, Ling Wang, Ming Li, Jing Zhu
In this work, we demonstrate the synthesis and application of a novel Co II -based metal-organic framework {[Co 2 (Dcpp)(Bpe) 0.5 (H 2 O)(μ 2 -H 2 O)]·(Bpe) 0.5 } n (Co II -MOF, H 4 Dcpp = 4,5-bis(4'-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection. Single-crystal X-ray diffraction analysis shows that the Co II -MOF has a two-dimensional (2D) bilayer structure composed of Co 2 units and Dcpp 4- ligands. There are two kinds of Bpe in the structure: one serves as a bidentate ligand linking two Co1 atoms in each 2D layer; the other is just free in the lattice...
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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