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https://www.readbyqxmd.com/read/29443839/how-common-and-how-serious-is-clostridium-difficile-colitis-after-geriatric-hip-fracture-findings-from-the-nsqip-dataset
#1
Patawut Bovonratwet, Daniel D Bohl, Glenn S Russo, Nathaniel T Ondeck, Denis Nam, Craig J Della Valle, Jonathan N Grauer
BACKGROUND: Patients with geriatric hip fractures may be at increased risk for postoperative Clostridium difficile colitis, which can cause severe morbidity and can influence hospital quality metrics. However, to our knowledge, no large database study has calculated the incidence of, factors associated with, and effect of C. difficile colitis on geriatric patients undergoing hip fracture surgery. QUESTIONS/PURPOSES: To use a large national database with in-hospital and postdischarge data (National Surgical Quality Improvement Program [NSQIP®]) to (1) determine the incidence and timing of C...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29439003/impact-of-red-and-processed-meat-and-fibre-intake-on-treatment-outcomes-among-patients-with-chronic-inflammatory-diseases-protocol-for-a-prospective-cohort-study-of-prognostic-factors-and-personalised-medicine
#2
Robin Christensen, Berit L Heitmann, Karina Winther Andersen, Ole Haagen Nielsen, Signe Bek Sørensen, Mohamad Jawhara, Anette Bygum, Lone Hvid, Jakob Grauslund, Jimmi Wied, Henning Glerup, Ulrich Fredberg, Jan Alexander Villadsen, Søren Geill Kjær, Jan Fallingborg, Seyed A G R Moghadd, Torben Knudsen, Jacob Brodersen, Jesper Frøjk, Jens Frederik Dahlerup, Anders Bo Bojesen, Grith Lykke Sorensen, Steffen Thiel, Nils J Færgeman, Ivan Brandslund, Tue Bjerg Bennike, Allan Stensballe, Erik Berg Schmidt, Andre Franke, David Ellinghaus, Philip Rosenstiel, Jeroen Raes, Mette Boye, Lars Werner, Charlotte Lindgaard Nielsen, Heidi Lausten Munk, Anders Bathum Nexøe, Torkell Ellingsen, Uffe Holmskov, Jens Kjeldsen, Vibeke Andersen
INTRODUCTION: Chronic inflammatory diseases (CIDs) are frequently treated with biological medications, specifically tumour necrosis factor inhibitors (TNFi)). These medications inhibit the pro-inflammatory molecule TNF alpha, which has been strongly implicated in the aetiology of these diseases. Up to one-third of patients do not, however, respond to biologics, and lifestyle factors are assumed to affect treatment outcomes. Little is known about the effects of dietary lifestyle as a prognostic factor that may enable personalised medicine...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29422811/duodenal-amyloidosis-secondary-to-ulcerative-colitis
#3
Seung Woon Park, Sam Ryong Jee, Ji Hyun Kim, Sang Heon Lee, Jin Won Hwang, Ji Geon Jang, Dong Woo Lee, Sang Yong Seol
Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29420567/outcome-and-clinical-course-of-ehec-o104-infection-in-hospitalized-patients-a-prospective-single-center-study
#4
J P Albersmeier, J P Bremer, W Dammermann, S Lüth, F Hagenmüller, C Rüther, H Otto, A M Nielsen, U Schumacher, S Ullrich
OBJECTIVES: Shiga-toxin producing O157:H7 Entero Haemorrhagic E. coli [STEC/EHEC] are the most common cause of Haemolytic Uraemic Syndrome [HUS] related to infectious haemorrhagic colitis. Nearly all recommendations on long term treatment of EHEC infections refer to this strain. The 2011 outbreak in Northern Europe was the first of this dimension to be caused by the serotype O104:H4. We report on the 3.5 year follow up of 61 patients diagnosed with symptomatic EHEC O104:H4 infection in spring 2011...
2018: PloS One
https://www.readbyqxmd.com/read/29390512/venous-thromboembolism-related-to-cytomegalovirus-infection-a-case-report-and-literature-review
#5
Amar H Kelkar, Kavitha S Jacob, Eman B Yousif, John J Farrell
RATIONALE: Herein, we present a case of seemingly unprovoked portal vein thrombosis (PVT) occurring in the context of an acute cytomegalovirus (CMV) infection and prolonged debilitating fatigue. PATIENT CONCERNS: A 46-year-old male airline pilot presented with a 2 week history of abdominal pain, nausea, vomiting, watery diarrhea, and daily recurrent fevers. This was in the context of progressive, debilitating fatigue for 3 months forcing the patient to leave his job...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29363355/biologic-induced-infections-in-inflammatory-bowel-disease-the-tnf-%C3%AE-antagonists
#6
Sean M McConachie, Sheila M Wilhelm, Ashish Bhargava, Pramodini B Kale-Pradhan
OBJECTIVE: To review the mechanism and association of infectious risk among the tumor-necrosis factor α (TNF-α) antagonists used in inflammatory bowel disease. DATA SOURCES: A PubMed literature search was performed using the following search terms: infliximab, adalimumab, certolizumab, golimumab, inflammatory bowel disease, crohn's, ulcerative colitis, adverse effects, adverse events, safety, and infection. STUDY SELECTION AND DATA EXTRACTION: Meta-analyses and cohort studies with outcomes pertaining to quantitative infectious risk were reviewed...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29211811/challenges-in-the-diagnosis-of-ulcerative-colitis-with-concomitant-bacterial-infections-and-chronic-infectious-colitis
#7
Wei-Chen Lin, Chen-Wang Chang, Ming-Jen Chen, Cheng-Hsin Chu, Shou-Chuan Shih, Tzu-Chi Hsu, Horng-Yang Wang
Ulcerative colitis (UC) is a chronic inflammation of the large bowel characterized by diarrhea and a negative stool culture. However, several enteropathogens have been implicated as causative agents in UC. The differentiation between chronic infectious colitis (IC) and UC with concurrent infection is difficult owing to their similar clinical presentations. The study aimed to explore the presentations and diagnostic clues that enable differentiation between UC with concomitant infections and chronic IC. The study included 17 UC patients with a bacterial infection and 46 with chronic IC...
2017: PloS One
https://www.readbyqxmd.com/read/29208963/enhanced-cd25-foxp3-regulatory-t-cell-development-by-amodiaquine-through-activation-of-nuclear-receptor-4a
#8
Hee Yeon Won, Ji Hyun Shin, Sera Oh, Hana Jeong, Eun Sook Hwang
CD4+ T cells play key roles in the regulation of immune responses against pathogenic infectious antigens via development into effector T helper and induced regulatory T (iTreg) cells. Particularly, CD4+CD25+Foxp3+ iTreg cells are crucial for maintaining immune homeostasis and controlling inflammatory diseases. Anti-inflammatory drugs that enhance iTreg cell generation would be effective at preventing and treating inflammatory and autoimmune diseases. In this study, we examined whether anti-malarial and anti-arthritic amodiaquine (AQ) could affect iTreg cell development...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29196305/multiple-simultaneous-infections-in-a-patient-with-well-controlled-hiv-when-occam-s-razor-fails
#9
Miranda Sherley, Sarah Jane Martin
Multiple concurrent infectious processes have previously been reported in the context of advanced HIV with significant immunosuppression. Here we report a case of multiple infections in a 56-year-old man with well-controlled HIV diagnosed 5 years earlier. Soon after returning to Australia following 12 years living in Thailand, he became unwell with fevers, night sweats, arthralgia and myalgia. There were no localising symptoms and examination was unremarkable. Investigations revealed positive syphilis (Treponema pallidum) serology with an RPR of 16, a positive urine culture (Klebsiella pneumoniae), a pulmonary nodule, a liver abscess and colitis (Entamoeba histolytica)...
December 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29167716/oral-manifestations-of-gastrointestinal-disorders
#10
REVIEW
Martin Jajam, Patricia Bozzolo, Sven Niklander
Background: A considerable number of gastrointestinal disorders (GIDs) of varied nature (inflammatory, infectious, genetic and other etiology) may produce alterations in the hard and soft oral tissues. Among these are Crohn's disease, ulcerative colitis, celiac and gastroesophageal reflux disease. Material and Methods: Article search was done using the National library of medicine (PubMed) database using different search terms and analyzed according to their importance...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29126502/clinical-presentation-of-crohn-s-ulcerative-colitis-and-indeterminate-colitis-symptoms-extraintestinal-manifestations-and-disease-phenotypes
#11
Yangyang R Yu, J Ruben Rodriguez
The incidence of inflammatory bowel disease (IBD) is rising with 25% of IBD diagnosed in children under 18 years of age. The clinical presentation of IBD in children is often vague leading to initial misdiagnosis as infectious colitis or irritable bowel syndrome. When IBD is identified, overlap in histologic and endoscopic features may lead to difficulty distinguishing Crohn's disease from ulcerative colitis, resulting in a higher frequency of the diagnosis indeterminate colitis or IBD unspecified. Recognizing the common and the atypical presentation of pediatric IBD and extraintestinal manifestations will aid in expeditious referral and early diagnosis...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29124893/ischaemic-colitis-uncertainty-in-diagnosis-pathophysiology-and-management
#12
REVIEW
Amanda L Nikolic, James O Keck
Ischaemic colitis is the most common form of gastrointestinal ischaemia, but may be confused with acute mesenteric ischaemia, inflammatory bowel disease or infectious colitis. This review article outlines the current classification, epidemiology and risk factors, as well as approaches about diagnosis and management to guide clinical practice. It also identifies areas for further research.
November 9, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29104126/long-term-quality-of-life-associated-with-early-surgical-complications-in-patients-with-ulcerative-colitis-after-ileal-pouch-anal-anastomosis-a-single-center-retrospective-study
#13
Weimin Xu, Hairong Ye, Yilian Zhu, Wenjun Ding, Jihong Fu, Long Cui, Peng Du
BACKGROUND: Ileal pouch-anal anastomosis (IPAA) is recommended for patients with ulcerative colitis (UC) in terms of surgical treatment. Measuring surgical complications of IPAA and long-term quality of life (QOL) are important to achieve an acceptable risk/benefit ratio for patients with UC. MATERIALS AND METHODS: Patients with UC who underwent total proctocolectomy (TPC) with IPAA from February 2008 to July 2016 at our institute were included. Early surgical complications were defined as mechanical/infectious events within one month after IPAA...
November 7, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29103205/diagnostic-dilemmas-in-chronic-inflammatory-bowel-disease
#14
Maurice B Loughrey, Neil A Shepherd
Histopathological assessment of biopsy and resection specimens of chronic inflammatory bowel disease (CIBD), or possible CIBD, forms a significant component of the routine workload in most tissue pathology laboratories. In this review, we have chosen selected areas of particular diagnostic difficulty in CIBD pathology, providing key advice for pathology reporting. Those mimics of CIBD which have the greatest potential for misdiagnosis are discussed, particularly the wide range of infectious colitides which represent possible diagnostic pitfalls...
November 4, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29058101/dock8-deficiency-presenting-as-an-ipex-like-disorder
#15
Fayhan J Alroqi, Louis-Marie Charbonnier, Sevgi Keles, Fatima Ghandour, Pierre Mouawad, Rami Sabouneh, Reem Mohammed, Abduarahman Almutairi, Janet Chou, Michel J Massaad, Raif S Geha, Zeina Baz, Talal A Chatila
PURPOSE: The dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive-combined immunodeficiency whose clinical spectra include recurrent infections, autoimmunity, malignancies, elevated serum IgE, eczema, and food allergies. Here, we report on patients with loss of function DOCK8 mutations with profound immune dysregulation suggestive of an immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX)-like disorder. METHODS: Immunophenotyping of lymphocyte subpopulations and analysis of DOCK8 protein expression were evaluated by flow cytometry...
November 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29047391/report-of-a-case-combining%C3%A2-solitary-peutz-jeghers-polyp-colitis-cystica-profunda-and-high-grade-dysplasia-of-the-epithelium%C3%A2-of-the-colon
#16
Alexandros Papalampros, Michail G Vailas, Maria Sotiropoulou, Efstratia Baili, Spiridon Davakis, Demetrios Moris, Evangelos Felekouras, Ioanna Deladetsima
BACKGROUND: Colitis cystica profunda is a rare nonneoplastic disease defined by the presence of intramural cysts that contain mucus, usually situated in the rectosigmoid area, which can mimic various malignant lesions and polyps. Its etiology still remains not fully elucidated, and several mechanisms such as congenital, post-traumatic, and infectious have been implicated in the development of this rare entity. CASE PRESENTATION: Herein, we describe a unique case of colitis cystica profunda in the setting of Peutz-Jeghers-type polyp of the sigmoid colon, associated with high-grade dysplasia of the overlying epithelium in a 48-year-old female patient, who presented to the emergency room with signs of intestinal obstruction...
October 18, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29018144/ogilvie-s-syndrome-treated-with-an-emergency-laparotomy-right-hemicolectomy-and-end-ileostomy
#17
Andrew James Robinson, John-Patrick Quigley, Athene Banks, Martin Farmer
Acute colonic pseudo-obstruction (ACPO), or Ogilvie's syndrome, is a rare clinical entity in which there is massive non-toxic colonic dilatation in the absence of a mechanically obstructing lesion. It is an important yet poorly recognised cause of surgical morbidity and mortality occurring typically in elderly patients with multiple comorbidities. ACPO can often be reversed conservatively with colonoscopic or nasogastric decompression. Surgical intervention is seldom necessary. We present a case of Ogilvie's syndrome in which a healthy 76-year-old man developed life-threatening pseudo-obstruction following rib polytrauma after a mechanical fall...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28990642/quantitative-phase-microscopy-for-evaluation-of-intestinal-inflammation-and-wound-healing-utilizing-label-free-biophysical-markers
#18
REVIEW
Dominik Bettenworth, Arne Bokemeyer, Christopher Poremba, Nik Sheng Ding, Steffi Ketelhut, Philipp Lenz, Björn Kemper
Inflammatory bowel diseases (IBD) are inflammatory disorders of the gastrointestinal tract characterized by a chronic relapsing disease course. As uncontrolled intestinal inflammation can result in severe disease complications, recent treatment targets of IBD evolved toward seeking the absence of mucosal and histological inflammation. However, this approach requires adequate histological evaluation of IBD disease activity. The diagnostic challenge of histological examination of intestinal inflammation is documented by the multitude of proposed histological scoring systems...
October 9, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28981886/perioperative-use-of-vedolizumab-is-not-associated-with-postoperative-infectious-complications-in-patients-with-ulcerative-colitis-undergoing-colectomy
#19
Marc Ferrante, Anthony de Buck van Overstraeten, Nikkie Schils, Annick Moens, Gert Van Assche, Albert Wolthuis, Séverine Vermeire, André D'Hoore
Background and Aims: Preoperative use of vedolizumab has been associated with increased short-term postoperative infectious complications. We assessed this risk in a single-centre cohort of patients with ulcerative colitis undergoing colectomy. Methods: Chart review was performed for all colectomies between 2006 and 2016. Short-term postoperative [non]infectious complications were evaluated within 30 days after colectomy. The comprehensive complication index was calculated based on all reported events...
October 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28955479/granulomatous-colitis-more-than-a-canine-disease-a-case-of-escherichia-coli-associated-granulomatous-colitis-in-an-adult-cat
#20
Rodolfo Oliveira Leal, Kenny Simpson, Mélanie Fine, Jean-Charles Husson, Juan Hernandez
CASE SUMMARY: This report describes a 4-year-old cat with chronic intermittent haematochezia and faecal incontinence of 7 months' duration. Investigation revealed severe colonic multifocal mucosal ulcerations and infiltration of the mucosal lamina propria by large numbers of periodic acid-Schiff-positive macrophages. Fluorescence in situ hybridisation analysis of colonic biopsies revealed multifocal clusters of intracellular Escherichia coli. Treatment with fluoroquinolones for 6 weeks led to a complete resolution of clinical signs...
July 2017: JFMS Open Reports
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