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https://www.readbyqxmd.com/read/29444553/evaluation-of-biomarkers-for-treatment-selection-using-individual-participant-data-from-multiple-clinical-trials
#1
Chaeryon Kang, Holly Janes, Parvin Tajik, Henk Groen, Ben Mol, Corine Koopmans, Kim Broekhuijsen, Eva Zwertbroek, Maria van Pampus, Maureen Franssen
Biomarkers that predict treatment effects may be used to guide treatment decisions, thus improving patient outcomes. A meta-analysis of individual participant data (IPD) is potentially more powerful than a single-study data analysis in evaluating markers for treatment selection. Our study was motivated by the IPD that were collected from 2 randomized controlled trials of hypertension and preeclampsia among pregnant women to evaluate the effect of labor induction over expectant management of the pregnancy in preventing progression to severe maternal disease...
February 14, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29444338/construct-validity-of-the-heart-failure-screening-tool-heart-fast-to-identify-heart-failure-patients-at-risk-of-poor-self-care-rasch-analysis
#2
Nicholas A Reynolds, Chantal F Ski, Samantha M McEvedy, David R Thompson, Jan Cameron
AIM: To psychometrically evaluate the Heart Failure Screening Tool (Heart-FaST) via: i) examination of internal construct validity; ii) testing of scale function in accordance with design; and iii) recommendation for change/s, if items are not well adjusted, to improve psychometric credential. BACKGROUND: Self-care is vital to the management of heart failure. The Heart-FaST may provide a prospective assessment of risk, regarding the likelihood that patients with heart failure will engage in self-care...
February 14, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29444323/the-role-of-fat-and-inflammation-in-the-pathogenesis-and-management-of-osteoarthritis
#3
Hema Urban, Christopher B Little
OA is a complex disease involving mechanical, metabolic and inflammatory contributions to its aetiology. A key risk factor, obesity, is becoming an increasing focus of research due to its multiple potential impacts on OA incidence, progression and symptom severity. An increased load due to an increase in body mass has been well established as a mechanical contribution to the pathophysiology of OA. However, evidence of obesity-linked to OA in non-weight-bearing joints has implicated the biological role of adipose inflammation and metabolic abnormalities in OA...
February 9, 2018: Rheumatology
https://www.readbyqxmd.com/read/29444292/determinants-of-sleepiness-in-obstructive-sleep-apnea
#4
Bharati Prasad, Alana D Steffen, Hans P A Van Dongen, Francis M Pack, Inna Strakovsky, Bethany Staley, David F Dinges, Greg Maislin, Allan I Pack, Terri E Weaver
Study Objectives: Significant interindividual variability in sleepiness is observed in clinical populations with obstructive sleep apnea (OSA). This phenomenon is only partially explained by the apnea-hypopnea index (AHI). Understanding factors that lead to sleepiness is critical to effective management of patients with OSA. We examined demographic and other factors associated with sleepiness in OSA. Methods: Prospective study of 283 patients with newly diagnosed OSA by polysomnography (AHI ≥ 5 per hour)...
February 10, 2018: Sleep
https://www.readbyqxmd.com/read/29444224/a-systematic-review-with-meta-analysis-of-the-prevalence-of-gastroesophageal-reflux-in-congenital-diaphragmatic-hernia-pediatric-survivors
#5
J V Arcos-Machancoses, C Ruiz Hernández, J Martin de Carpi, S Pinillos Pisón
Congenital diaphragmatic hernia survivors are a well-known group at risk for developing gastroesophageal reflux disease that may be particularly long-term severe. The aim of this study is to provide a systematic review of the prevalence of gastroesophageal reflux in infant and children survivors treated for congenital diaphragmatic hernia.Electronic and manual searches were performed with keywords related to congenital diaphragmatic hernia, gastroesophageal reflux disease, and epidemiology terms. Summary estimates of the prevalence were calculated...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444129/long-term-habitat-changes-in-a-protected-area-implications-for-herpetofauna-habitat-management-and-restoration
#6
Chantel E Markle, Gillian Chow-Fraser, Patricia Chow-Fraser
Point Pelee National Park, located at the southern-most tip of Canada's mainland, historically supported a large number of herpetofauna species; however, despite nearly a century of protection, six snake and five amphibian species have disappeared, and remaining species-at-risk populations are thought to be in decline. We hypothesized that long-term changes in availability and distribution of critical habitat types may have contributed to the disappearance of herpetofauna. To track habitat changes we used aerial image data spanning 85 years (1931-2015) and manually digitized and classified image data using a standardized framework...
2018: PloS One
https://www.readbyqxmd.com/read/29444118/demographic-and-genetic-viability-of-a-medium-sized-ground-dwelling-mammal-in-a-fire-prone-rapidly-urbanizing-landscape
#7
Cristina E Ramalho, Kym M Ottewell, Brian K Chambers, Colin J Yates, Barbara A Wilson, Roberta Bencini, Geoff Barrett
The rapid and large-scale urbanization of peri-urban areas poses major and complex challenges for wildlife conservation. We used population viability analysis (PVA) to evaluate the influence of urban encroachment, fire, and fauna crossing structures, with and without accounting for inbreeding effects, on the metapopulation viability of a medium-sized ground-dwelling mammal, the southern brown bandicoot (Isoodon obesulus), in the rapidly expanding city of Perth, Australia. We surveyed two metapopulations over one and a half years, and parameterized the PVA models using largely field-collected data...
2018: PloS One
https://www.readbyqxmd.com/read/29444092/the-impact-of-early-life-nutrition-and-housing-on-growth-and-reproduction-in-dairy-cattle
#8
G Curtis, C McGregor Argo, D Jones, D Grove-White
Contentious issues in calf rearing include milk feeding practices and single versus group housing. The current study was performed on a high producing 170 Holstein cow dairy farm, to investigate the impact of nutrition and housing on growth and reproduction. Heifer calves (n = 100) were allocated in birth order to one of two commonly used management strategies. All calves received 3-4 litres of dam specific colostrum within 6 hours of birth. Group A calves were group housed from birth and fed milk replacer (MR) ad libitum via a computerised machine utilising a single teat, with weaning commencing at 63 days of age...
2018: PloS One
https://www.readbyqxmd.com/read/29443919/a-novel-strategy-for-very-large-scale-cash-crop-mapping-in-the-context-of-weather-related-risk-assessment-combining-global-satellite-multispectral-datasets-environmental-constraints-and-in-situ-acquisition-of-geospatial-data
#9
Fabio Dell'Acqua, Gianni Cristian Iannelli, Marco A Torres, Mario L V Martina
Cash crops are agricultural crops intended to be sold for profit as opposed to subsistence crops, meant to support the producer, or to support livestock. Since cash crops are intended for future sale, they translate into large financial value when considered on a wide geographical scale, so their production directly involves financial risk. At a national level, extreme weather events including destructive rain or hail, as well as drought, can have a significant impact on the overall economic balance. It is thus important to map such crops in order to set up insurance and mitigation strategies...
February 14, 2018: Sensors
https://www.readbyqxmd.com/read/29443839/how-common-and-how-serious-is-clostridium-difficile-colitis-after-geriatric-hip-fracture-findings-from-the-nsqip-dataset
#10
Patawut Bovonratwet, Daniel D Bohl, Glenn S Russo, Nathaniel T Ondeck, Denis Nam, Craig J Della Valle, Jonathan N Grauer
BACKGROUND: Patients with geriatric hip fractures may be at increased risk for postoperative Clostridium difficile colitis, which can cause severe morbidity and can influence hospital quality metrics. However, to our knowledge, no large database study has calculated the incidence of, factors associated with, and effect of C. difficile colitis on geriatric patients undergoing hip fracture surgery. QUESTIONS/PURPOSES: To use a large national database with in-hospital and postdischarge data (National Surgical Quality Improvement Program [NSQIP®]) to (1) determine the incidence and timing of C...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29443835/venous-thromboembolism-incidence-after-craniofacial-surgery
#11
Wilson I Omesiete, James A Walker, Jack C Yu
INTRODUCTION: Current protocols for venous thromboembolism (VTE) prophylaxis after craniofacial surgery (CFS) vary widely with substantial disagreements in both indications and managements. An evidence-based approach to this issue requires the following: the incidence of postoperative VTE, comorbidities associated with coagulopathy, risk reduction after VTE prophylaxis, and complications attributable to prophylaxis. This study addresses the first two. DESIGN: Retrospective cross-sectional study...
February 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29443648/readmission-patterns-after-gi-cancer-hospitalizations-the-medical-versus-surgical-patient
#12
Joanna-Grace M Manzano, Ming Yang, Hui Zhao, Linda S Elting, Marina C George, Ruili Luo, Maria E Suarez-Almazor
PURPOSE: Readmission within 30 days has been used as a metric for quality of care received at hospitals for certain diagnoses. In the era of accountability, value-based care, and increasing cancer costs, policymakers are looking into cancer readmissions as well. It is important to describe the readmission profile of patients with cancer in the most clinically relevant approach to inform policy and health care delivery that can positively impact patient outcomes. PATIENTS AND METHODS: We conducted a retrospective cohort study using linked Texas Cancer Registry and Medicare claims data...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29443439/complexity-of-the-relationships-of-pain-posttraumatic-stress-and-depression-in-combat-injured-populations-an-integrative-review-to-inform-evidence-based-practice
#13
Nicholas A Giordano, Christine Bader, Therese S Richmond, Rosemary C Polomano
BACKGROUND: Understanding the complex interrelationships between combat injuries, physical health, and mental health symptoms is critical to addressing the healthcare needs of wounded military personnel and veterans. The relationship between injury characteristics, pain, posttraumatic stress disorder (PTSD), and depression among combat-injured military personnel is unique to modern conflicts and understudied in the nursing literature. AIM: This integrative review synthesizes clinical presentations and relationships of combat injury, PTSD, depression, and pain in Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) United States military service members and veterans...
February 14, 2018: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29443421/diabetes-uk-evidence-based-nutrition-guidelines-for-the-prevention-and-management-of-diabetes
#14
P A Dyson, D Twenefour, C Breen, A Duncan, E Elvin, L Goff, A Hill, P Kalsi, N Marsland, P McCardle, D Mellor, L Oliver, K Watson
A summary of the latest evidence-based nutrition guidelines for the prevention and management of diabetes is presented. These guidelines are based on existing recommendations last published in 2011, and were formulated by an expert panel of specialist dietitians after a literature review of recent evidence. Recommendations have been made in terms of foods rather than nutrients wherever possible. Guidelines for education and care delivery, prevention of Type 2 diabetes, glycaemic control for Type 1 and Type 2 diabetes, cardiovascular disease risk management, management of diabetes-related complications, other considerations including comorbidities, nutrition support, pregnancy and lactation, eating disorders, micronutrients, food supplements, functional foods, commercial diabetic foods and nutritive and non-nutritive sweeteners are included...
February 14, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29443045/routine-screening-method-for-microparticles-in-platelet-transfusions
#15
Daniel Millar, Larry Murphy, Audrey Labrie, Elisabeth Maurer-Spurej
Platelet inventory management based on screening microparticle content in platelet concentrates is a new quality improvement initiative for hospital blood banks. Cells fragment off microparticles (MP) when they are stressed. Blood and blood components may contain cellular fragments from a variety of cells, most notably from activated platelets. When performing their roles as innate immune cells and major players in coagulation and hemostasis, platelets change shape and generate microparticles. With dynamic light scattering (DLS)-based microparticle detection, it is possible to differentiate activated (high microparticle) from non-activated (low microparticle) platelets in transfusions, and optimize the use of this scarce blood product...
January 31, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442238/two-point-measurement-of-amylase-in-drainage-fluid-predicts-severe-postoperative-pancreatic-fistula-after-gastric-cancer-surgery
#16
Satoshi Kamiya, Naoki Hiki, Koshi Kumagai, Michitaka Honda, Souya Nunobe, Manabu Ohashi, Takeshi Sano, Toshiharu Yamaguchi
BACKGROUND: Early identification of patients at risk of postoperative pancreatic fistula (POPF) allows appropriate management after gastrectomy. Although some reports have suggested a correlation between POPF and the concentration of amylase in drained abdominal fluid (D-AMY), this has not been proven to impact sufficiently on clinical decision-making. A sustained high level of D-AMY is often assumed to be due to unsatisfactory drainage or excessive pancreatic leakage. We assessed the clinical utility of measuring D-AMY on postoperative day (POD) 1 and POD3 for prediction of POPF...
February 13, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29442136/spontaneous-regression-of-a-large-calcified-thoracic-disk-extrusion
#17
Hayley Oligane, Jean Rongo, Vikas Agarwal, Barton F Branstetter
Although spontaneous regression of herniated disk material has been reported in the lumbar and cervical spine, reports of complete spontaneous regression of calcified thoracic disk herniations are exceedingly rare. In symptomatic patients, surgery is typically the treatment of choice; however, conservative therapy with surveillance may allow time for spontaneous resolution and potentially avoid high-risk surgery. We report a 40-year-old woman with complete spontaneous resolution of a large calcified thoracic disk extrusion with conservative management over an 8-month period...
February 13, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29441818/comparative-effectiveness-and-harms-of-intraoperative-transesophageal-echocardiography-in-noncardiac-surgery-a-systematic-review
#18
Ashraf Fayad, Sasha Shillcutt, Massimiliano Meineri, Terrence D Ruddy, Mohammed Toseef Ansari
Intraoperative use of transesophageal echocardiography (TEE) has become commonplace in high-risk noncardiac surgeries but the balance of benefits and harms remains unclear. This systematic review investigated the comparative effectiveness and harms of intraoperative TEE in noncardiac surgery. We searched Ovid MEDLINE, PubMed, EMBASE, and the Cochrane Library from 1946 to March 2017. Two reviewers independently screened the literature for eligibility. Studies were assessed for the risk of selection bias, confounding, measurement bias, and reporting bias...
February 1, 2018: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29441796/heart-failure-symptoms-profile-associated-with-depressive-symptoms
#19
Lucinda J Graven, Melinda K Higgins, Carolyn M Reilly, Sandra B Dunbar
Heart failure (HF) symptoms are known to influence depressive symptoms, yet a symptom profile has not been identified. HF symptoms relative to symptom experience (frequency, severity, interference with physical activity and enjoyment of life) associated with depressive symptoms were examined. Data from three HF studies ( N = 308) which used the Heart Failure Symptom Survey were included in this cross-sectional secondary analysis. Supervised classification for and identification of symptoms most associated with depressive symptoms were accomplished using random forest algorithms via conditional inference trees...
February 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29441700/knowledge-about-cervical-cancer-and-barriers-toward-cervical-cancer-screening-among-hiv-positive-women-attending-public-health-centers-in-addis-ababa-city-ethiopia
#20
Saba Shiferaw, Adamu Addissie, Muluken Gizaw, Selamawit Hirpa, Wondimu Ayele, Sefonias Getachewe, Eva J Kantelhardt, Mathewos Assefa, Ahmedin Jemal
Screening rate for cervical cancer among HIV-infected women and among women overall is low in Ethiopia despite the high burden of the disease and HIV infection, which increases cervical cancer risk. In this paper, we assessed knowledge about cervical cancer symptoms, prevention, early detection, and treatment and barriers to screening among HIV-positive women attending community health centers for HIV-infection management in Addis Ababa. A cross-sectional survey of 581 HIV-positive women aged 21-64 years old attending 14 randomly selected community health centers without cervical cancer screening service in Addis Ababa...
February 14, 2018: Cancer Medicine
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