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https://www.readbyqxmd.com/read/29679872/maize-productivity-heavy-metals-uptake-and-their-availability-in-contaminated-clay-and-sandy-alkaline-soils-as-affected-by-inorganic-and-organic-amendments
#1
Mahmoud F Seleiman, Ahmed M S Kheir
Contamination of arid and semi-arid ecosystems by toxic heavy metals is a serious concern due to its impact on growth and productivity of crop and health risk through food chain. Therefore, the aims of this investigation were to study the impact of inorganic (i.e. nano hydroxyapatite, NHA and polyacrylamide, PAM) and organic (i.e. sugar beet factory lime, SBFL and biochar, BI) soil amendments on maize productivity grown in contaminated silty clay (i.e. fluvial, lacustrine) and sandy (i.e. marine) alkaline soils...
April 15, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679857/the-risk-of-immune-related-endocrine-disorders-associated-with-anti-pd-1-inhibitors-therapy-for-solid-tumors-a-systematic-review-and-meta-analysis
#2
Qiang Su, Xiao-Chen Zhang, Di-Ya Wang, Huai-Rong Zhang, Cheng Zhu, Yan-Li Hou, Jun-Li Liu, Zu-Hua Gao
BACKGROUND: We performed a systematic review and meta-analysis to evaluate the risk of immune-related endocrine disorders associated with PD-1 inhibitors therapy for solid tumors. METHODS: An Embase and PubMed search through December 6, 2017, using the following keywords was performed: immune-related endocrine disorders, and PD-1 inhibitors, etc. The data were analyzed using R 3.4.3 (R Project) and the metafor package. Patients treated with chemotherapy alone were used as control for the purpose of comparison...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679815/dual-docking-robotic-surgical-staging-for-high-risk-endometrial-cancer
#3
Cécile Loaec, Anne-Sophie Bats, Charlotte Ngo, Caroline Cornou, Léa Rossi, Chérazade Bensaid, Claude Nos, Fabrice Lecuru
OBJECTIVE: The standard of care for patients with high intermediate and high risk endometrial cancer is surgical staging including total hysterectomy with bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy. Over the past decade, laparoscopic or robot-assisted minimally invasive surgery has showed many benefits in the management of endometrial cancer. Few studies have specifically assessed the use of minimally invasive surgery for staging of high risk endometrial cancer...
April 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29679726/late-presenting-dural-tear-incidence-risk-factors-and-associated-complications
#4
Wesley M Durand, J Mason DePasse, Eren O Kuris, JaeWon Yang, Alan H Daniels
BACKGROUND CONTEXT: Unrecognized and inadequately repaired intraoperative durotomies may lead to cerebrospinal fluid leak, pseudomeningocele, and other complications. Few studies have investigated durotomy that is unrecognized intraoperatively and requires additional postoperative management (hereafter, late-presenting dural tear [LPDT]), though estimates of LPDT range from 0.6 - 8.3 per 1,000 spinal surgeries. These single-center studies are based on relatively small sample sizes for an event of this rarity, all with <10 patients experiencing LPDT...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679617/retinopathy-of-prematurity-a-review-of-risk-factors-and-their-clinical-significance
#5
REVIEW
Sang Jin Kim, Alexander D Port, Ryan Swan, J Peter Campbell, R V Paul Chan, Michael F Chiang
Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors...
April 19, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29679598/sleep-in-women-across-the-lifespan
#6
REVIEW
Martino Pengo, Christine Won, Ghada Bourjeily
There are many ways in which women experience sleep differently than men. Women contend with distinct sleep challenges, respond differently to sleep disorders, sleep deprivation and deficiency, and face particular health outcomes as a result of poor sleep. Idiosyncrasies - including changes that occur with the biological life cycles of menstruation, pregnancy, and menopause- make the understanding of sleep in women an important topic to study. Each phase of a woman's life, from childhood to menopause, increases the risk of sleep disturbance in unique ways that may require distinct management...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29679428/estimating-sensitivity-of-seabed-habitats-to-disturbance-by-bottom-trawling-based-on-the-longevity-of-benthic-fauna
#7
Adriaan D Rijnsdorp, Stefan G Bolam, Clement Garcia, Jan Geert Hiddink, Niels T Hintzen, P Daniel van Denderen, Tobias van Kooten
Bottom fishing such as trawling and dredging may pose serious risks to the seabed and benthic habitats, calling for a quantitative assessment method to evaluate the impact and guide management to develop mitigation measures. We provide a method to estimate the sensitivity of benthic habitats based on the longevity composition of the invertebrate community. We hypothesize that long-lived species are more sensitive to trawling mortality due to their lower pace of life (i.e. slower growth, late maturation). We analyse data from box-core and grab samples taken from 401 stations in the English Channel and southern North Sea to estimate the habitat-specific longevity composition of the benthic invertebrate community and of specific functional groups (i...
April 20, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29679354/low-serum-phosphate-is-associated-with-ischemic-stroke-in-hemodialysis-patients
#8
Tsang-Shan Chen, Chao-Hung Chen, Chien-An Chen, Li-Ping Chou, Chi-Chu Liu
BACKGROUND: Hemodialysis patients have a high incidence of ischemic stroke. However, the association between serum phosphate levels and ischemic stroke is controversial among hemodialysis patients. The present study is used to evaluate whether serum phosphate levels are associated with ischemic stroke among patients undergoing hemodialysis. METHODS: A total of 84 hemodialysis patients were followed up for 8 years. Data collection included chart reviews and assessments of laboratory records...
April 20, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29679303/do-the-sglt-2-inhibitors-offer-more-than-hypoglycemic-activity
#9
REVIEW
Eduardo Flores, Carlos G Santos-Gallego, Nely Diaz-Mejía, Juan Jose Badimon
Type 2 diabetes mellitus (T2DM) is one of the most common chronic health conditions in the USA; it affects approximately 10% of adults with up to one-quarter being undiagnosed. T2DM is associated with substantial cardiovascular (CV) morbidity and mortality. T2DM is a pathological condition characterized by elevated levels of glucose and associated with high CV risk. Traditional hypoglycemic drugs have demonstrated their capability for effective and maintained management of high glucose levels, but they have not significantly impacted on the incidence of CV events...
April 20, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29679023/interventions-for-lower-extremity-peripheral-artery-disease
#10
REVIEW
Jade S Hiramoto, Martin Teraa, Gert J de Borst, Michael S Conte
Peripheral artery disease (PAD) of the lower extremities is a common manifestation of atherosclerosis that is increasing in global prevalence and in the associated public health costs. Ageing of the general population, combined with the pandemics of diabetes mellitus, metabolic syndrome, and tobacco use, is a major underlying factor. A broad range of care providers are involved in the management of patients with PAD, and all health-care professionals require familiarity with the risk factors, diagnosis, and treatment options for this common disease...
April 20, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29678994/can-exercise-delay-transition-to-active-therapy-in-men-with-low-grade-prostate-cancer-a-multicentre-randomised-controlled-trial
#11
Daniel A Galvão, Dickon Hayne, Mark Frydenberg, Suzanne K Chambers, Dennis R Taaffe, Nigel Spry, Paul A Scuffham, Robert S Ware, Nicolas H Hart, Robert U Newton
INTRODUCTION: Active surveillance is a strategy for managing low-risk, localised prostate cancer, where men are observed with serial prostate-specific antigen assessments to identify signs of disease progression. Currently, there are no strategies to support active surveillance compliance nor are there interventions that can prevent or slow disease progression, ultimately delaying transition to active treatment before it is clinically required. Recently, we proposed that exercise may have a therapeutic potential in delaying the need for active treatment in men on active surveillance...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678988/qualitative-evaluation-of-an-educational-intervention-to-reduce-medicolegal-risks-for-medical-doctors-experiencing-significantly-more-cases-than-their-peers-in-the-uk-and-ireland
#12
John Jolly, Paul Bowie, Julie Price, Matt Mason, Mark Dinwoodie
OBJECTIVES: The Medical Protection Society (MPS) is a leading protection organisation for healthcare professionals worldwide. In the UK and Ireland, a small minority of MPS members experience significantly more medicolegal cases than their peers and are invited to participate in a risk education (RE) remediation process. To understand more about this educational intervention, we sought to explore participating doctors' views of their experiences of this process and identify self-reported performance improvements and what elements of the intervention could be improved...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678967/development-and-evaluation-of-an-algorithm-based-tool-for-medication-management-in-nursing-homes-the-amber-study-protocol
#13
Susanne Erzkamp, Olaf Rose
BACKGROUND: Residents of nursing homes are susceptible to risks from medication. Medication Reviews (MR) can increase clinical outcomes and the quality of medication therapy. Limited resources and barriers between healthcare practitioners are potential obstructions to performing MR in nursing homes. Focusing on frequent and relevant problems can support pharmacists in the provision of pharmaceutical care services. This study aims to develop and evaluate an algorithm-based tool that facilitates the provision of Medication Management in clinical practice...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678945/ers-ecdc-statement-european-union-standards-for-tuberculosis-care-2017-update
#14
G B Migliori, G Sotgiu, S Rosales-Klintz, R Centis, L D'Ambrosio, I Abubakar, G Bothamley, J A Caminero, D M Cirillo, M Dara, G de Vries, S Aliberti, A T Dinh-Xuan, R Duarte, F Midulla, I Solovic, D Subotic, M Amicosante, A M Correira, A Cirule, G Gualano, H Kunst, F Palmieri, V Riekstina, S Tiberi, R Verduin, M J van der Werf
The International Standards for Tuberculosis (TB) Care define the essential level of care for managing patients who have or are presumed to have TB, or are at increased risk of developing the disease. The resources and capacity in the European Union and the European Economic Area (EU/EEA) permit higher standards of care to secure quality and timely TB diagnosis, prevention and treatment. On this basis, the European Union Standards for Tuberculosis Care (ESTC) were published in 2012 as standards specifically tailored to the EU-setting...
April 20, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29678900/prevention-of-exacerbations-in-patients-with-stable-non-cystic-fibrosis-bronchiectasis-a-systematic-review-and-meta-analysis-of-pharmacological-and-non-pharmacological-therapies
#15
Abd Moain Abu Dabrh, Adam T Hill, Claudia C Dobler, Noor Asi, Wigdan H Farah, Qusay Haydour, Zhen Wang, Khalid Benkhadra, Larry J Prokop, Mohammad Hassan Murad
BACKGROUND: Several pharmacological and non-pharmacological therapies are used to treat stable bronchiectasis of non-cystic fibrosis (CF) aetiology. OBJECTIVE: We conducted a systematic review and meta-analysis to assess the evidence of the effectiveness of pharmacological and non-pharmacological treatment options in patients with stable non-CF bronchiectasis with a focus on reducing exacerbations. STUDY SELECTION: Multiple databases were searched through September 2017...
April 20, 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29678687/clinical-characteristics-and-outcomes-of-patients-with-multiple-simultaneous-superficial-vein-thrombi
#16
Rishi Chopra, Luis R Leon, Nicos Labropoulos
BACKGROUND: Although unprovoked superficial venous thrombosis (SVT) has traditionally been considered a local, benign disorder, recent studies demonstrate that patients with SVT are at significant risk for deep venous thrombosis, pulmonary embolism, and other venous thromboembolism (VTE) events. Nevertheless, clinical management remains widely inconsistent. Moreover, patients with multiple, unprovoked SVTs of noncommunicating anatomic sites have not been previously described, and they may be at even increased risk for adverse outcomes...
April 17, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29678607/association-between-hypertension-and-metabolic-disorders-among-elderly-patients-in-north-jordan
#17
Nuha Alwardat, Laura Di Renzo, Renata Costa de Miranda, Sofian Alwardat, Paola Sinibaldi Salimei, Antonino De Lorenzo
BACKGROUND: Hypertension (HTN), dyslipidemia and hyperglycemia are major risk factors for cardiovascular disease, accounting for the highest morbidity and mortality among the elderly Jordanian population. This study aimed to evaluate serum lipid and glucose profiles of hypertensive patients and normotensive controls, and determine the risk factors for HTN among elderly population in Jordan. METHODS: A cross-sectional study was carried out among 200 participants, including 111 hypertensive patients and 89 normotensive controls from June to October 2017 in North Jordan...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678605/hypoglycemia-in-type-2-dm-patients-review-article
#18
REVIEW
Ayla M Tourkmani, Turki J Alharbi, Abdulaziz M Bin Rsheed, Abdulrhamn N AlRasheed, Saad M AlBattal, Osama Abdelhay, Mohamed A Hassali, Alian A Alrasheedy, Nouf G Al Harbi, Abdulaziz Alqahtani
Hypoglycemia is an essential issue for diabetic patients and considered a limiting factor in the glycemic management. Heterogeneity of the diseases in Type 2 Diabetes Mellitus can affect the frequency of hypoglycemia, especially when the patient has cardiovascular diseases. There are several factors lead to hypoglycemia sulfonylurea therapy, insulin therapy, delayed or missed a meal, physical exercise, or drug or alcohol consumption. Long-term studies reported that repeated hypoglycemia is increasing the risk of cardiovascular disease...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678488/medicolegal-considerations-involving-iatrogenic-lingual-nerve-damage
#19
REVIEW
Roberto Pippi, Andrea Spota, Marcello Santoro
The aim of this review is to improve risk management strategies through analysis of the anatomic, semeiotic, and medicolegal aspects that characterize iatrogenic lingual nerve damage (LND) and its legal consequences in the case of legal proceedings for a claim for compensation. In dental practice, LND can be caused by local or general anesthesia or by mechanical, chemical, or thermal mechanisms. A certain postoperative identification of LND etiopathogenesis is often very challenging because it can be difficult to show at what time the damage occurred and which mechanism actually caused it...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29678471/hematologic-toxicity-from-radium-223-therapy-for-bone-metastases-in-castration-resistant-prostate-cancer-risk-factors-and-practical-considerations
#20
REVIEW
Heather Jacene, Leonard Gomella, Evan Y Yu, Eric M Rohren
Radium-223 dichloride is an α-emitting radiopharmaceutical that localizes to bone matrix and is approved for the treatment of patients with metastatic castration-resistant prostate cancer (CRPC) and symptomatic bone metastases. The cumulative impact of Ra-223 and other therapeutic agents for metastatic CRPC on myelosuppression in bone marrow is unknown. The phase 3 randomized, double-blind, placebo-controlled ALSYMPCA trial of Ra-223 in patients with CRPC and symptomatic bone metastases demonstrated a significant improvement in overall survival...
March 23, 2018: Clinical Genitourinary Cancer
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