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Vascular, endovascular, stem cell, progenitor cell,

Peixi Liu, Yingjie Zhou, Qingzhu An, Yaying Song, Xi Chen, Guo-Yuan Yang, Wei Zhu
UNLABELLED: : This study explored a new approach to enhance aneurysm (AN) neck endothelialization via erythropoietin (EPO)-induced endothelial progenitor cell (EPC) stimulation. Results suggest that EPO enhanced the endothelialization of a coiled embolization AN neck by stimulating EPCs via vascular endothelial growth factor modulation. Thus, the promotion of endothelialization with EPO provides an additional therapeutic option for preventing the recurrence of ANs. Endovascular coil embolization is an attractive therapy for cerebral ANs, but recurrence is a main problem affecting long-term outcomes...
September 2016: Stem Cells Translational Medicine
Jun-Ichi Suzuki, Munehisa Shimamura, Hiroyuki Suda, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Mitsuaki Isobe, Issei Komuro, Ryuichi Morishita
Peripheral artery disease (PAD) is associated with elevated morbidity and mortality with cardiovascular (CV) disease. The guideline recommends smoking cessation and antiplatelet/antithrombotic drugs for asymptomatic and symptomatic PAD patients. It also recommends that PAD patients with critical limb ischemia (CLI) should be considered to receive endovascular and open surgical treatment for limb salvage. Although PAD patients with CLI receive these treatments, they are sometimes unable to deliver sufficient blood flow to eliminate their symptoms...
April 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Darian R Esfahani, Vyas Viswanathan, Ali Alaraj
Until recently, endovascular management of intracranial aneurysms has focused on mechanical and hemodynamic aspects: characterizing aneurysm morphology by angiogram, mechanical obstruction by detachable coils, and flow diversion with endovascular stents. Although now common practice, these interventions only ward off aneurysm rupture. The source of the problem, disease of the vessel wall itself, remains. New imaging technology and treatment modalities, however, are offering great promise to the field. In this review, we outline several new developments in the recent literature and pose potential adaptations toward cerebral aneurysms using them...
March 2015: Neurological Research
Francesco Moccia, Silvia Dragoni, Mariapia Cinelli, Stefania Montagnani, Bruno Amato, Vittorio Rosti, Germano Guerra, Franco Tanzi
Endothelial dysfunction or loss is the early event that leads to a host of severe cardiovascular diseases, such as atherosclerosis, hypertension, brain stroke, myocardial infarction, and peripheral artery disease. Ageing is regarded among the most detrimental risk factor for vascular endothelium and predisposes the subject to atheroscleorosis and inflammatory states even in absence of traditional comorbid conditions. Standard treatment to restore blood perfusion through stenotic arteries are surgical or endovascular revascularization...
2013: BMC Surgery
C Botti, C Maione, A Coppola, V Sica, G Cobellis
Inadequate blood supply to tissues caused by obstruction of arterioles and/or capillaries results in ischemic injuries - these injuries can range from mild (eg, leg ischemia) to severe conditions (eg, myocardial infarction, stroke). Surgical and/or endovascular procedures provide cutting-edge treatment for patients with vascular disorders; however, a high percentage of patients are currently not treatable, owing to high operative risk or unfavorable vascular involvement. Therapeutic angiogenesis has recently emerged as a promising new therapy, promoting the formation of new blood vessels by the introduction of bone marrow-derived stem and progenitor cells...
2012: Stem Cells and Cloning: Advances and Applications
Shu-chun Chen, Guang-yao Song, Yang Sun, Na Liu
OBJECTIVE: To study the relationship between oxidative stress and endothelial progenitor cells (EPCs) count in the first-degree relatives of diabetes mellitus (FDRs). METHODS: Three groups were evaluated with 40 type 2 diabetes mellitus (T2DM) patients, 38 FDRs and 30 healthy individuals as the control (NC). Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), TG, TC and fasting plasma insulin concentrations were measured and homeostasis model assessment-insulin resistance (HOMA-IR) was calculated...
March 2012: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
M Behjati, M Kazemi, M Hashemi, S H Zarkesh-Esfahanai, E Bahrami, B Hashemi-Beni, R Ahmadi
BACKGROUND: Enhanced attraction of selective vascular reparative cells is of great importance in order to increase vascular patency after endovascular treatments. We aimed to evaluate efficient attachment of endothelial cells and their progenitors on surfaces coated with mixture of specific antibodies, L-selectin and VE-cadherin, with prohibited platelet attachment. METHODS: The most efficient conditions for coating of L-selectin-Fc chimera and VE-cadherin-Fc chimera proteins were first determined by protein coating on ELISA plates...
August 20, 2013: International Journal of Cardiology
Iman Moradi, Mohaddeseh Behjati, Mohammad Kazemi
OBJECTIVES: To study the efficacy of an effective anodized titanium surface with enhanced attachment of endothelial progenitor cell (EPC). BACKGROUND: In-stent restenosis is a major obstacle for vascular patency after catheter-based intravascular interventions. Recently, stents that capture EPCs have been paid attention in order to make a functional endothelialized layer at the site of stent-induced endothelial denudation. Anodized titanium has been shown to enhance stem cell attachment...
2012: Nanoscale Research Letters
Katharina S Volz, Erik Miljan, Amanda Khoo, John P Cooke
Peripheral arterial disease (PAD) is characterized by reduced limb blood flow due to arterial obstruction. Current treatment includes surgical or endovascular procedures, the failure of which may result in amputation of the affected limb. An emerging therapeutic approach is cell therapy to enhance angiogenesis and tissue survival. Small clinical trials of adult progenitor cell therapies have generated promising results, although large randomized clinical trials using well-defined cells have not been performed...
May 2012: Vascular Pharmacology
Hui-Jie Wei, Dong Wang, Jie-Li Chen, Yong Xu, Ping Lei, Rong-Cai Jiang, Li Liu, Jing-Fei Dong, Jian-Ning Zhang
Emerging evidence shows that circulating endothelial progenitor cells (EPCs) promote regeneration of the endothelium at sites of vessel injury. This study was designed to test the hypothesis that EPCs are mobilized in patients who had ruptured cerebral aneurysm (CA) and underwent endovascular therapy. Fourteen patients with ruptured CAs were recruited and blood samples were analyzed after coil embolization surgery. Blood samples were also obtained from 18 healthy control subjects who had no evidence of CAs and did not undergo endovascular surgery...
July 8, 2011: Neuroscience Letters
M Avci-Adali, N Perle, G Ziemer, H P Wendel
Circulating endothelial progenitor cells (EPCs) in the peripheral blood of adults represent an auspicious cell source for tissue engineering of an autologous endothelium on blood-contacting implants. Novel materials biofunctionalised with EPC-specific capture molecules represent an intriguing strategy for induction of selective homing of progenitor cells. The trapped EPCs can differentiate into endothelial cells and generate a non-thrombogenic surface on artificial materials. However, the success of this process mainly depends on the use of optimised capture molecules with a high selectivity and affinity...
2011: European Cells & Materials
Holger Lawall, Peter Bramlage, Berthold Amann
Peripheral arterial disease (PAD) is a highly prevalent atherosclerotic syndrome associated with significant morbidity and mortality. PAD is most commonly caused by atherosclerosis obliterans (ASO) and thromboangiitis obliterans (TAO), and can lead to claudication and critical limb ischemia (CLI), often resulting in a need for major amputation and subsequent death. Standard treatment for such severe cases of PAD is surgical or endovascular revascularization. However, up to 30% of patients are not candidates for such interventions, due to high operative risk or unfavorable vascular involvement...
February 2011: Journal of Vascular Surgery
Peng Gao, Yongmei Chen, Michael T Lawton, Nicholas M Barbaro, Guo-Yuan Yang, Hua Su, Feng Ling, William L Young
BACKGROUND: Brain and spinal cord arteriovenous malformations (AVMs) are characterized by aberrant angiogenesis and vascular remodeling. Endothelial progenitor cells (EPCs) can be recruited by stromal cell-derived factor-1 (SDF-1), and participate in vascular remodeling in both physiological and pathological settings. OBJECTIVE: To investigate whether there are increased EPC levels in the brain and spinal cord AVM nidus. METHODS: Microsurgical specimens without endovascular embolization and radiosurgery from the brain (n = 12) and spinal cord (n = 5) AVMs were examined...
October 2010: Neurosurgery
Peter E Westerweel, Cindy T J van Velthoven, Tri Q Nguyen, Krista den Ouden, Dominique P V de Kleijn, Marie Jose Goumans, Roel Goldschmeding, Marianne C Verhaar
BACKGROUND: Diabetic patients experience exaggerated intimal hyperplasia after endovascular procedures. Recently it has been shown that circulating smooth muscle progenitor cells (SPC) contribute to intimal hyperplasia. We hypothesized that SPC differentiation would be increased in diabetes and focused on modulation of TGF-β/BMP-6 signaling as potential underlying mechanism. METHODS: We isolated SPC from C57Bl/6 mice with streptozotocin-induced diabetes and controls...
2010: Cardiovascular Diabetology
Gian Paolo Fadini, Angelo Avogaro
The endothelium plays a central role in cardiovascular regulation. Endothelial cells produce a variety of vasculoregulatory and vasculotropic molecules that act locally or at distant sites. Alteration of the vascular endothelium is a primary event in the pathogenesis of vascular diseases, such as atherosclerosis, as well as systemic and pulmonary hypertension. For these reasons, the study of human endothelium has become central in cardiovascular research. Unfortunately, technologies handling endothelial cells in vitro are often criticized due to the uncertain transferability of results to intact organs and, importantly, to humans...
July 1, 2010: Cardiovascular Research
Gareth J Padfield, David E Newby, Nicholas L Mills
Percutaneous coronary intervention is associated with mechanical endovascular injury and endothelial denudation. Re-endothelialization is essential for restoration of normal vascular homeostasis and regulation of neointimal hyperplasia. The endothelial progenitor cell recently emerged as an important component of the response to vascular injury, having the potential to accelerate vascular repair through rapid re-endothelialization. There remains considerable uncertainty over the precise identity and function of endothelial progenitor cells, and harnessing their therapeutic potential remains a challenge...
April 13, 2010: Journal of the American College of Cardiology
Holger Lawall, Peter Bramlage, Berthold Amann
Atherosclerotic peripheral artery disease (PAD) is a common manifestation of atherosclerosis. The occlusion of large limb arteries leads to ischaemia with claudication which can progress to critical limb ischaemia (CLI) with pain at rest, and to tissue loss. At present, common therapy for CLI is either surgical or endovascular revascularisation aimed at improving blood flow to the affected extremity. However, major amputation and death are still frequent complications. Exploring new strategies for revascularisation of ischaemic limbs is thus of major importance...
April 2010: Thrombosis and Haemostasis
Augusto Orlandi, Martin Bennett
Accumulation of vascular smooth muscle cells (VSMCs) in the tunica intima plays a major role in the pathogenesis of atherosclerosis and restenosis following endovascular procedures. Arterial VSMCs are heterogeneous even in the normal vessel wall and display different phenotypes in physiological and pathological conditions. In the classical paradigm, vascular wall injury induces VSMC de-differentiation, proliferation and migration from the media into the intima in response to growth factors and proteolytic agents...
June 15, 2010: Biochemical Pharmacology
Xabier L Aranguren, Catherine M Verfaillie, Aernout Luttun
Peripheral vascular disease (PVD) is a growing medical problem in Western societies and presents itself mainly in two different clinical forms. Intermittent claudication is an early moderate manifestation, while patients with critical limb ischemia suffer from severe muscle tissue loss or ulcers and are at high risk for limb amputation. Unfortunately, many patients cannot be helped with currently available surgical or endovascular revascularization procedures because of the complex anatomy of the vascular occlusion and/or the presence of other risk factors...
January 2009: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
D Chen, M Weber, P G Shiels, R Dong, Z Webster, J H McVey, G Kemball-Cook, E G D Tuddenham, R I Lechler, A Dorling
BACKGROUND: Coagulation proteins promote neointimal hyperplasia and vascular remodelling after vessel injury, but the precise mechanisms by which they act in vivo remain undetermined. OBJECTIVES: This study, using an injury model in which the neointima is derived from bone marrow (BM)-derived cells, compared inhibition of tissue factor or thrombin on either BM-derived or existing vascular smooth muscle cells. METHODS: Two transgenic (Tg) mouse strains expressing membrane-tethered tissue factor pathway inhibitor (TFPI) or hirudin (Hir) fusion proteins driven by an alpha smooth muscle actin (SMA) promoter were generated (alpha-TFPI-Tg and alpha-Hir-Tg) and the phenotype after wire-induced endovascular injury was compared with that in wild-type (WT) controls...
October 2006: Journal of Thrombosis and Haemostasis: JTH
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