Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Karolina Augustyniak, Aleksandra Pragnaca, Monika Lesniak, Marta Halasa, Agata Borkowska, Ewa Pieta, Wojciech M Kwiatek, Claudine Kieda, Robert Zdanowski, Kamilla Malek
Circulating endothelial cell progenitors originating from the bone marrow are considered to be a powerful tool in the repair of endothelium damage. Due to their unique properties, endothelial progenitors are now broadly investigated to assess their clinical significance in diseases e.g., associated with brain endothelial dysfunction. However, their distinction in terms of the expression of specific markers remains ambiguous. Additionally, endothelial progenitor cells may change their repertoire of markers depending on the microenvironment of the tissue in which they are currently located...
October 18, 2023: Cellular and Molecular Life Sciences: CMLS
#22
JOURNAL ARTICLE
Samuel E Honeycutt, Pierre-Emmanuel Y N'Guetta, Deanna M Hardesty, Yubin Xiong, Shamus L Cooper, Matthew J Stevenson, Lori L O'Brien
The kidneys intricate vascular system supports body fluid and organ homeostasis. However, little is known about how vascular architecture is established during kidney development. More specifically, how signals from the kidney influence vessel maturity and patterning remains poorly understood. Netrin-1 (Ntn1) is a secreted ligand critical for vessel and neuronal guidance. Here, we demonstrate that Ntn1 is expressed by Foxd1+ stromal progenitors in the developing kidney and conditional deletion (Foxd1GC/+;Ntn1fl/fl) results in hypoplastic kidneys with extended nephrogenesis...
October 11, 2023: Development
#23
JOURNAL ARTICLE
Y Liu, S Ding, J F Sun, P P Li, X Q Li, L Y Zeng, K L Xu, J L Qiao
Objective: To observe the effect of platelets on hematopoietic stem cell (HSCs) implantation in mice with radiation-induced bone marrow injury and bone marrow transplantation models. Methods: ①Male C57BL/6 mice were divided into a single irradiation group and a radiation infusion group after receiving (60)Co semimyeloablative irradiation for 18-10 weeks. The irradiation infusion group received 1×10(8) platelets expressing GFP fluorescent protein. ② The allogeneic bone marrow transplantation model was established...
August 14, 2023: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
#24
JOURNAL ARTICLE
Yan-Yan Heng, Hui-Juan Shang, Xia-Ze Zhang, Wei Wei
BACKGROUND: Endothelial progenitor cells (EPCs) transplantation is one of the effective therapies for neointima associated with endothelial injury. Diabetes impairs the function of EPCs and cumbers neointima prevention of EPC transplantation with an ambiguous mechanism. Sodium Tanshinone IIA Sulfonate (STS) is an endothelium-protective drug but whether STS protects EPCs in diabetes is still unknown. METHODS: EPCs were treated with High Glucose (HG), STS, and Nucleotide-binding Domain-(NOD) like Receptor 3 (NLRP3), caspase-1, the Receptor of Advanced Glycation End products (AGEs) (RAGE) inhibitors, Thioredoxin-Interacting Protein (TXNIP) siRNA, and EPC proliferation, differentiation functions, and senescence were detected...
September 11, 2023: BMC Cardiovascular Disorders
#25
JOURNAL ARTICLE
Pankaj Sahai-Hernandez, Claire Pouget, Shai Eyal, Ondrej Svoboda, Jose Chacon, Lin Grimm, Tor Gjøen, David Traver
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic stem and progenitor cells (HSPCs) arise from ventral aortic endothelium in all vertebrate animals studied. Work in zebrafish has demonstrated that arterial and venous endothelial precursors arise from distinct subsets of lateral plate mesoderm. Here, we profile the transcriptome of the earliest detectable endothelial cells (ECs) during zebrafish embryogenesis to demonstrate that tissue-specific EC programs initiate much earlier than previously appreciated, by the end of gastrulation...
September 11, 2023: ELife
#26
JOURNAL ARTICLE
Sara Menegatti, Bethany Potts, Roberto Paredes, Eva Garcia-Alegria, Syed Murtuza Baker, Valerie Kouskoff
During embryonic development, all blood progenitors are initially generated from endothelial cells that acquire a hemogenic potential. Blood progenitors emerge through an endothelial-to-hematopoietic transition regulated by the transcription factor RUNX1. To date, we still know very little about the molecular characteristics of hemogenic endothelium and the molecular changes underlying the transition from endothelium to hematopoiesis. Here, we analyzed at the single cell level a human embryonic stem cell-derived endothelial population containing hemogenic potential...
September 15, 2023: IScience
#27
REVIEW
Dina M Ibrahim, Aleksandra Fomina, Carlijn V C Bouten, Anthal I P M Smits
The use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brings...
September 8, 2023: Advanced Drug Delivery Reviews
#28
JOURNAL ARTICLE
Stanislao Igor Travisano, Michael R M Harrison, Matthew E Thornton, Brendan H Grubbs, Thomas Quertermous, Ching-Ling Lien
Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease, and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are closely associated with coronary arteries, similar to those in zebrafish hearts. We identify a population of cardiac lymphatic endothelial cells (LECs) that reside in the epicardium. Single-nuclei multiomic analysis of the human fetal heart reveals the plasticity and heterogeneity of the cardiac endothelium. Furthermore, we find that VEGFC is highly expressed in arterial endothelial cells and epicardium-derived cells, providing a molecular basis for the arterial association of cardiac lymphatic development...
September 6, 2023: Cell Reports
#29
REVIEW
Layla Pohl, Ina Maria Schiessl
Renal endothelial cells demonstrate an impressive remodeling potential during angiogenic sprouting, vessel repair or while transitioning into mesenchymal cells. These different processes may play important roles in both renal disease progression or regeneration while underlying signaling pathways of different endothelial cell plasticity routes partly overlap. Angiogenesis contributes to wound healing after kidney injury and pharmaceutical modulation of angiogenesis may home a great therapeutic potential. Yet, it is not clear whether any differentiated endothelial cell can proliferate or whether regenerative processes are largely controlled by resident or circulating endothelial progenitor cells...
September 4, 2023: Acta Physiologica
#30
JOURNAL ARTICLE
Wei-Hang Zhu, Jie Chen, Run-Kai Huang, Yuan Zhang, Ze-Xuan Huang, Xiu-Qing Pang, Bo Hu, Yang Yang, Xing Li
Rationale : Hepatocellular carcinoma (HCC) is primarily characterized by a high incidence of vascular invasion. However, the specific mechanism underlying portal vein tumor thrombus (PVTT) in HCC remains unclear. As a consequence of myeloid cell developmental arrest, CD71+ erythroid progenitor cells (EPCs) and myeloid-derived suppressor cells play important roles in HCC; however, their roles in PVTT remain unclear. Methods: The role of CD71+ EPCs in the HCC tumor microenvironment (TME) was evaluated via morphological, RNA-sequencing, enzyme-linked immunosorbent assay, and flow cytometric analyses...
2023: Theranostics
#31
Yuqi Zhu, Sriram Neelamegham
UNLABELLED: The recruitment of peripheral blood neutrophils at sites of inflammation involves a multistep cascade, starting with E- and P-selectin expressed on the inflamed vascular endothelium binding sialofucosylated glycans on leukocytes. As the glycoconjugate biosynthesis pathways in different cells are distinct, the precise carbohydrate ligands of selectins varies both across species, and between different immune cell populations in a given species. To study this aspect in human neutrophils, we developed a protocol to perform CRISPR/Cas9 gene-editing on CD34+ hHSCs (human hematopoietic stem/progenitor cells) as they are differentiated towards neutrophil lineage...
August 19, 2023: bioRxiv
#32
JOURNAL ARTICLE
Ting Chen, Xiaotong Sun, Hui Gong, Mengjia Chen, Yaning Li, Yuesheng Zhang, Ting Wang, Xueyin Huang, Zuoshi Wen, Jianing Xue, Peng Teng, Yanhua Hu, Li Zhang, Jun Yang, Qingbo Xu, Weidong Li
BACKGROUND: Endothelium dysfunction is a central problem for early rejection due to the host alloimmune response and the late status of arteriosclerosis in heart transplantation. However, reliable pieces of evidence are still limited concerning the source of the regenerated endothelium within the transplanted heart. METHODS: We analyzed single-cell RNA sequencing data and constructed an inducible lineage tracing mouse, combined heart transplantation with bone marrow transplantation and a parabiosis model, cellular components, and endothelial cell populations in cardiac graft lesions...
August 25, 2023: Journal of Heart and Lung Transplantation
#33
REVIEW
Ao Li, Jinhua Yan, Ya Zhao, Zhenping Yu, Shane Tian, Abdul Haseeb Khan, Yuanzheng Zhu, Andong Wu, Cuntai Zhang, Xiao-Li Tian
Vascular aging represents a collection of structural and functional changes in a blood vessel with advancing age, including increased stiffness, vascular wall remodeling, loss of angiogenic ability, and endothelium-dependent vasodilation dysfunction. These age-related alterations may occur earlier in those who are at risk for or have cardiovascular diseases, therefore, are defined as early or premature vascular aging. Vascular aging contributes independently to cardio-cerebral vascular diseases (CCVDs). Thus, early diagnosis and interventions targeting vascular aging are of paramount importance in the delay or prevention of CCVDs...
2023: Clinical Interventions in Aging
#34
JOURNAL ARTICLE
Kevin W O'Connor, Tiantian Liu, Sunkyung Kim, Carlos G Briseño, Katia Georgopoulos, Theresa L Murphy, Kenneth M Murphy
Ly6Clo monocytes are a myeloid subset that specializes in the surveillance of vascular endothelium. Ly6Clo monocytes have been shown to derive from Ly6Chi monocytes. NOTCH2 signaling has been implicated as a trigger for Ly6Clo monocyte development, but the basis for this effect is unclear. Here, we examined the impact of NOTCH2 signaling of myeloid progenitors on the development of Ly6Clo monocytes in vitro. NOTCH2 signaling induced by delta-like ligand 1 (DLL1) efficiently induced the transition of Ly6Chi TREML4- monocytes into Ly6Clo TREML4+ monocytes...
August 29, 2023: Proceedings of the National Academy of Sciences of the United States of America
#35
JOURNAL ARTICLE
Issac Goh, Rachel A Botting, Antony Rose, Simone Webb, Justin Engelbert, Yorick Gitton, Emily Stephenson, Mariana Quiroga Londoño, Michael Mather, Nicole Mende, Ivan Imaz-Rosshandler, Lu Yang, Dave Horsfall, Daniela Basurto-Lozada, Nana-Jane Chipampe, Victoria Rook, Jimmy Tsz Hang Lee, Mai-Linh Ton, Daniel Keitley, Pavel Mazin, M S Vijayabaskar, Rebecca Hannah, Laure Gambardella, Kile Green, Stephane Ballereau, Megumi Inoue, Elizabeth Tuck, Valentina Lorenzi, Kwasi Kwakwa, Clara Alsinet, Bayanne Olabi, Mohi Miah, Chloe Admane, Dorin-Mirel Popescu, Meghan Acres, David Dixon, Thomas Ness, Rowen Coulthard, Steven Lisgo, Deborah J Henderson, Emma Dann, Chenqu Suo, Sarah J Kinston, Jong-Eun Park, Krzysztof Polanski, John Marioni, Stijn van Dongen, Kerstin B Meyer, Marella de Bruijn, James Palis, Sam Behjati, Elisa Laurenti, Nicola K Wilson, Roser Vento-Tormo, Alain Chédotal, Omer Bayraktar, Irene Roberts, Laura Jardine, Berthold Göttgens, Sarah A Teichmann, Muzlifah Haniffa
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs...
August 18, 2023: Science
#36
JOURNAL ARTICLE
Maria A Rincon-Benavides, Natalia Claire Mendonca, Tatiana Z Cuellar-Gaviria, Ana I Salazar-Puerta, Lilibeth Ortega-Pineda, Britani N Blackstone, Binbin Deng, David W McComb, Daniel Gallego-Perez, Heather M Powell, Natalia Higuita-Castro
Vasculogenic cell therapies have emerged as a powerful tool to increase vascularization and promote tissue repair/regeneration. Current approaches to cell therapies, however, rely mostly on progenitor cells, which pose significant risks (e.g., uncontrolled differentiation, tumorigenesis, and genetic/epigenetic abnormalities). Moreover, reprogramming methodologies used to generate induced endothelial cells (iECs) from induced pluripotent stem cells rely heavily on viral vectors, which pose additional translational limitations...
March 2023: Advanced Therapeutics
#37
JOURNAL ARTICLE
Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.
Ivy Kn Chiang, David Humphrey, Richard J Mills, Peter Kaltzis, Shikha Pachauri, Matthew Graus, Diptarka Saha, Zhijian Wu, Paul Young, Choon Boon Sim, Tara Davidson, Andres Hernandez-Garcia, Chad A Shaw, Alexander Renwick, Daryl A Scott, Enzo R Porrello, Emily S Wong, James E Hudson, Kristy Red-Horse, Gonzalo Del Monte-Nieto, Mathias Francois
The cardiac endothelium influences ventricular chamber development by coordinating trabeculation and compaction. However, the endothelial-specific molecular mechanisms mediating this coordination are not fully understood. Here, we identify the Sox7 transcription factor as a critical cue instructing cardiac endothelium identity during ventricular chamber development. Endothelial-specific loss of Sox7 function in mice results in cardiac ventricular defects similar to non-compaction cardiomyopathy, with a change in the proportions of trabecular and compact cardiomyocytes in the mutant hearts...
August 8, 2023: EMBO Reports
#38
JOURNAL ARTICLE
Tian-Tian Liu, Huan-Huan Xu, Ze-Juan Liu, He-Ping Zhang, Hai-Tao Zhou, Zhi-Xiang Zhu, Zhi-Qiang Wang, Jing-Yi Xue, Qiang Li, Yi Ma, Hong-Jie You, Da-Li Luo
Endothelial dysfunction, a central hallmark of cardiovascular pathogenesis in diabetes mellitus, is characterized by impaired endothelial nitric oxide synthase (eNOS) and NO bioavailability. However, the underlying mechanisms remain unclear. Here in this study, we aimed to identify the role of calmodulin (CaM) in diabetic eNOS dysfunction. Human umbilical vein endothelial cells and murine endothelial progenitor cells (EPCs) treated with high glucose (HG) exhibited downregulated CaM mRNA/protein and vascular endothelial growth factor (VEGF) expression with impeded eNOS phosphorylation and cell migration/tube formation...
July 19, 2023: Acta Pharmacologica Sinica
#39
JOURNAL ARTICLE
Joey J Ghersi, Gabriel Baldissera, Jared Hintzen, Stephanie A Luff, Siyuan Cheng, Ivan Fan Xia, Christopher M Sturgeon, Stefania Nicoli
Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of haemogenic endothelial cells in the aorta-gonad-mesonephros (AGM). HSPCs in the AGM are heterogeneous in differentiation and proliferative output, but how these intrinsic differences are acquired remains unanswered. Here we discovered that loss of microRNA (miR)-128 in zebrafish leads to an expansion of HSPCs in the AGM with different cell cycle states and a skew towards erythroid and lymphoid progenitors...
July 17, 2023: Nature Cell Biology
#40
JOURNAL ARTICLE
Dake Hao, Jonathan Lin, Ruiwu Liu, Christopher Pivetti, Kaeli Yamashiro, Linda M Schutzman, Junichiro Sageshima, Mimmie Kwong, Nataliya Bahatyrevich, Diana L Farmer, Misty D Humphries, Kit S Lam, Alyssa Panitch, Aijun Wang
Implantable vascular devices are widely used in clinical treatments for various vascular diseases. However, current approved clinical implantable vascular devices generally have high failure rates primarily due to their surface lacking inherent functional endothelium. Here, inspired by the pathological mechanisms of vascular device failure and physiological functions of native endothelium, we developed a new generation of bioactive parylene (poly(p-xylylene))-based conformal coating to address these challenges of the vascular devices...
October 2023: Bioactive Materials
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
