keyword
https://read.qxmd.com/read/38485719/selective-deletion-of-e3-ubiquitin-ligase-fbw7-in-ve-cadherin-positive-cells-instigates-diffuse-large-b-cell-lymphoma-in-mice-in-vivo
#1
JOURNAL ARTICLE
Zhaohua Cai, Shaojin You, Zhixue Liu, Ping Song, Fujie Zhao, Junqing An, Ye Ding, Ben He, Ming-Hui Zou
During the maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, developing lymphocytes may undergo malignant transformation and produce B-cell lymphomas. Emerging evidence shows that through the endothelial-hematopoietic transition, specialized endothelial cells called the hemogenic endothelium can differentiate into HSPCs. However, the contribution of genetic defects in hemogenic endothelial cells to B-cell lymphomagenesis has not yet been investigated. Here, we report that mice with endothelial cell-specific deletion of Fbw7 spontaneously developed diffuse large B-cell lymphoma (DLBCL) following Bcl6 accumulation...
March 14, 2024: Cell Death & Disease
https://read.qxmd.com/read/38392289/mitochondrial-dysfunction-in-endothelial-progenitor-cells-unraveling-insights-from-vascular-endothelial-cells
#2
REVIEW
Azra Kulovic-Sissawo, Carolina Tocantins, Mariana S Diniz, Elisa Weiss, Andreas Steiner, Silvija Tokic, Corina T Madreiter-Sokolowski, Susana P Pereira, Ursula Hiden
Endothelial dysfunction is associated with several lifestyle-related diseases, including cardiovascular and neurodegenerative diseases, and it contributes significantly to the global health burden. Recent research indicates a link between cardiovascular risk factors (CVRFs), excessive production of reactive oxygen species (ROS), mitochondrial impairment, and endothelial dysfunction. Circulating endothelial progenitor cells (EPCs) are recruited into the vessel wall to maintain appropriate endothelial function, repair, and angiogenesis...
January 23, 2024: Biology
https://read.qxmd.com/read/38383534/cis-inhibition-of-notch1-through-jagged1-sustains-embryonic-hematopoietic-stem-cell-fate
#3
JOURNAL ARTICLE
Roshana Thambyrajah, Maria Maqueda, Wen Hao Neo, Kathleen Imbach, Yolanda Guillén, Daniela Grases, Zaki Fadlullah, Stefano Gambera, Francesca Matteini, Xiaonan Wang, Fernando J Calero-Nieto, Manel Esteller, Maria Carolina Florian, Eduard Porta, Rui Benedito, Berthold Göttgens, Georges Lacaud, Lluis Espinosa, Anna Bigas
Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium (HE) in the aorta- gonads-and mesonephros (AGM) region and reside within Intra-aortic hematopoietic clusters (IAHC) along with hematopoietic progenitors (HPC). The signalling mechanisms that distinguish HSCs from HPCs are unknown. Notch signaling is essential for arterial specification, IAHC formation and HSC activity, but current studies on how Notch segregates these different fates are inconsistent. We now demonstrate that Notch activity is highest in a subset of, GFI1 + , HSC-primed HE cells, and is gradually lost with HSC maturation...
February 21, 2024: Nature Communications
https://read.qxmd.com/read/38383474/endothelial-robo4-suppresses-endothelial-to-mesenchymal-transition-induced-by-irradiation-and-improves-hematopoietic-reconstitution
#4
JOURNAL ARTICLE
Seyram Yao Adzraku, Can Cao, Qi Zhou, Ke Yuan, Xiaowen Hao, Yue Li, Shengnan Yuan, Yujin Huang, Kailin Xu, Jianlin Qiao, Wen Ju, Lingyu Zeng
Bone marrow ablation is routinely performed before hematopoietic stem cell transplantation (HSCT). Hematopoietic stem and progenitor cells (HSPCs) require a stable bone marrow microenvironment to expand and refill the peripheral blood cell pool after ablation. Roundabout guidance receptor 4 (Robo4) is a transmembrane protein exclusive to endothelial cells and is vital in preserving vascular integrity. Hence, the hypothesis is that Robo4 maintains the integrity of bone marrow endothelial cells following radiotherapy...
February 21, 2024: Cell Death & Disease
https://read.qxmd.com/read/38363844/glycolytic-state-of-aortic-endothelium-favors-hematopoietic-transition-during-the-emergence-of-definitive-hematopoiesis
#5
JOURNAL ARTICLE
Anu Pv, Shubham Haribhau Mehatre, Catherine M Verfaillie, Mohammad Tauqeer Alam, Satish Khurana
The first definitive hematopoietic progenitors emerge through the process of endothelial-to-hematopoietic transition in vertebrate embryos. With molecular regulators for this process worked out, the role of metabolic pathways used remains unclear. Here, we performed nano-LC-MS/MS-based proteomic analysis and predicted a metabolic switch from a glycolytic to oxidative state upon hematopoietic transition. Mitochondrial activity, glucose uptake, and glycolytic flux analysis supported this hypothesis. Systemic inhibition of lactate dehydrogenase A (LDHA) increased oxygen consumption rate in the hemato-endothelial system and inhibited the emergence of intra-aortic hematopoietic clusters...
February 16, 2024: Science Advances
https://read.qxmd.com/read/38339164/immunological-profile-and-markers-of-endothelial-dysfunction-in-elderly-patients-with-cognitive-impairments
#6
JOURNAL ARTICLE
Nikolay V Goncharov, Polina I Popova, Igor V Kudryavtsev, Alexey S Golovkin, Irina V Savitskaya, Piotr P Avdonin, Ekaterina A Korf, Natalia G Voitenko, Daria A Belinskaia, Maria K Serebryakova, Natalia V Matveeva, Natalia O Gerlakh, Natalia E Anikievich, Marina A Gubatenko, Irina A Dobrylko, Andrey S Trulioff, Arthur D Aquino, Richard O Jenkins, Pavel V Avdonin
The process of aging is accompanied by a dynamic restructuring of the immune response, a phenomenon known as immunosenescence. Further, damage to the endothelium can be both a cause and a consequence of many diseases, especially in elderly people. The purpose of this study was to carry out immunological and biochemical profiling of elderly people with acute ischemic stroke (AIS), chronic cerebral circulation insufficiency (CCCI), prediabetes or newly diagnosed type II diabetes mellitus (DM), and subcortical ischemic vascular dementia (SIVD)...
February 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38212000/-epcs-exos-combined-with-tanshinone-%C3%A2-_a-protect-vascular-endothelium-cells-from-oxidative-damage-via-pi3k-akt-pathway
#7
JOURNAL ARTICLE
Lu Ma, Lei Yang, Chang-Qing Deng, Wei Zhang, Huang Ding, Xiao-Dan Liu, Wan-Yu Li, Jiang Wen, Wei Tan, Yan-Ling Li, Yan-Yan Zhang, Xin-Ying Fu, Lin-Quan Liu, Cai-Xia Liu, Zhao-Wen Zeng
This study aims to investigate the molecular mechanism of tanshinone Ⅱ_(A )(TaⅡ_A) combined with endothelial progenitor cells-derived exosomes(EPCs-exos) in protecting the aortic vascular endothelial cells(AVECs) from oxidative damage via the phosphatidylinositol 3 kinase(PI3K)/protein kinase B(Akt) pathway. The AVECs induced by 1-palmitoyl-2-(5'-oxovaleroyl)-sn-glycero-3-phosphocholine(POVPC) were randomly divided into model, TaⅡ_A, EPCs-exos, and TaⅡ_A+EPCs-exos groups, and the normal cells were taken as the control group...
December 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38132657/her2-targeted-therapy-from-pathophysiology-to-clinical-manifestation-a-narrative-review
#8
REVIEW
Svetoslava Elefterova Slavcheva, Atanas Angelov
Trastuzumab is the primary treatment for all stages of HER2-overexpressing breast cancer in patients. Though discovered over 20 years ago, trastuzumab-induced cardiotoxicity (TIC) remains a research topic in cardio-oncology. This review explores the pathophysiological basis of TIC and its clinical manifestations. Their understanding is paramount for early detection and cardioprotective treatment. Trastuzumab renders cardiomyocytes susceptible by inhibiting the cardioprotective NRG-1/HER2/HER4 signaling pathway...
December 6, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38069208/ahr-and-cyp1b1-control-oxygen-effects-on-bone-marrow-progenitor-cells-the-enrichment-of-multiple-olfactory-receptors-as-potential-microbiome-sensors
#9
JOURNAL ARTICLE
Michele C Larsen, Catherine M Rondelli, Ahmed Almeldin, Yong-Seok Song, Alhaji N'Jai, David L Alexander, E Camilla Forsberg, Nader Sheibani, Colin R Jefcoate
Polycyclic aromatic hydrocarbon (PAH) pollutants and microbiome products converge on the aryl hydrocarbon receptor (AhR) to redirect selective rapid adherence of isolated bone marrow (BM) cells. In young adult mice, Cyp1b1-deficiency and AhR activation by PAH, particularly when prolonged by Cyp1a1 deletion, produce matching gene stimulations in these BM cells. Vascular expression of Cyp1b1 lowers reactive oxygen species (ROS), suppressing NF-κB/RelA signaling. PAH and allelic selectivity support a non-canonical AhR participation, possibly through RelA...
November 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38028440/light-at-the-endothelium-role-of-sox17-and-runx1-in-endothelial-dysfunction-and-pulmonary-arterial-hypertension
#10
REVIEW
Robert Simmons Beck, Olin D Liang, James R Klinger
Pulmonary arterial hypertension (PAH) is a progressive disease that is characterized by an obliterative vasculopathy of the distal pulmonary circulation. Despite significant progress in our understanding of the pathophysiology, currently approved medical therapies for PAH act primarily as pulmonary vasodilators and fail to address the underlying processes that lead to the development and progression of the disease. Endothelial dysregulation in response to stress, injury or physiologic stimuli followed by perivascular infiltration of immune cells plays a prominent role in the pulmonary vascular remodeling of PAH...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/37996457/nod1-dependent-nf-kb-activation-initiates-hematopoietic-stem-cell-specification-in-response-to-small-rho-gtpases
#11
JOURNAL ARTICLE
Xiaoyi Cheng, Radwa Barakat, Giulia Pavani, Masuma Khatun Usha, Rodolfo Calderon, Elizabeth Snella, Abigail Gorden, Yudi Zhang, Paul Gadue, Deborah L French, Karin S Dorman, Antonella Fidanza, Clyde A Campbell, Raquel Espin-Palazon
Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation, but also advance cellular immunotherapies. However, generating functional human induced pluripotent stem cell (hiPSC)-derived HSPCs and their derivatives has been elusive, necessitating a better understanding of the developmental mechanisms that trigger HSPC specification. Here, we reveal that early activation of the Nod1-Ripk2-NF-kB inflammatory pathway in endothelial cells (ECs) primes them to switch fate towards definitive hemogenic endothelium, a pre-requisite to specify HSPCs...
November 23, 2023: Nature Communications
https://read.qxmd.com/read/37981699/hif-1%C3%AE-promotes-kidney-organoid-vascularization-and-applications-in-disease-modeling
#12
JOURNAL ARTICLE
Kexin Peng, Wanqin Xie, Tingting Wang, Yamei Li, Jean de Dieu Habimana, Obed Boadi Amissah, Jufang Huang, Yong Chen, Bin Ni, Zhiyuan Li
BACKGROUND: Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell transplanting therapy. However, these applications are limited since kidney organoid cannot maintain complete morphology and function like human kidney. Kidney organoids are not well differentiated since the core of the organoid lacked oxygen, nutrition, and vasculature, which creates essential niches. Hypoxia-inducible factor-1 α (HIF-1α) serves as a critical regulator in vascularization and cell survival under hypoxia environment...
November 19, 2023: Stem Cell Research & Therapy
https://read.qxmd.com/read/37940670/single-cell-spatial-analysis-reveals-inflammatory-foci-of-immature-neutrophil-and-cd8-t-cells-in-covid-19-lungs
#13
JOURNAL ARTICLE
Praveen Weeratunga, Laura Denney, Joshua A Bull, Emmanouela Repapi, Martin Sergeant, Rachel Etherington, Chaitanya Vuppussetty, Gareth D H Turner, Colin Clelland, Jeongmin Woo, Amy Cross, Fadi Issa, Carlos Eduardo de Andrea, Ignacio Melero Bermejo, David Sims, Simon McGowan, Yasemin-Xiomara Zurke, David J Ahern, Eddie C Gamez, Justin Whalley, Duncan Richards, Paul Klenerman, Claudia Monaco, Irina A Udalova, Tao Dong, Agne Antanaviciute, Graham Ogg, Julian C Knight, Helen M Byrne, Stephen Taylor, Ling-Pei Ho
Single cell spatial interrogation of the immune-structural interactions in COVID -19 lungs is challenging, mainly because of the marked cellular infiltrate and architecturally distorted microstructure. To address this, we develop a suite of mathematical tools to search for statistically significant co-locations amongst immune and structural cells identified using 37-plex imaging mass cytometry. This unbiased method reveals a cellular map interleaved with an inflammatory network of immature neutrophils, cytotoxic CD8 T cells, megakaryocytes and monocytes co-located with regenerating alveolar progenitors and endothelium...
November 8, 2023: Nature Communications
https://read.qxmd.com/read/37922878/development-of-functional-resident-macrophages-in-human-pluripotent-stem-cell-derived-colonic-organoids-and-human-fetal-colon
#14
JOURNAL ARTICLE
Jorge O Múnera, Daniel O Kechele, Carine Bouffi, Na Qu, Ran Jing, Pritiprasanna Maity, Jacob R Enriquez, Lu Han, Ian Campbell, Maxime M Mahe, Heather A McCauley, Xinghao Zhang, Nambirajan Sundaram, Jonathan R Hudson, Adrian Zarsozo-Lacoste, Suman Pradhan, Kentaro Tominaga, J Guillermo Sanchez, Alison A Weiss, Praneet Chatuvedi, Jason R Spence, Mariam Hachimi, Trista North, George Q Daley, Christopher N Mayhew, Yueh-Chiang Hu, Takanori Takebe, Michael A Helmrath, James M Wells
Most organs have tissue-resident immune cells. Human organoids lack these immune cells, which limits their utility in modeling many normal and disease processes. Here, we describe that pluripotent stem cell-derived human colonic organoids (HCOs) co-develop a diverse population of immune cells, including hemogenic endothelium (HE)-like cells and erythromyeloid progenitors that undergo stereotypical steps in differentiation, resulting in the generation of functional macrophages. HCO macrophages acquired a transcriptional signature resembling human fetal small and large intestine tissue-resident macrophages...
November 2, 2023: Cell Stem Cell
https://read.qxmd.com/read/37893151/clonal-and-scalable-endothelial-progenitor-cell-lines-from-human-pluripotent-stem-cells
#15
JOURNAL ARTICLE
Jieun Lee, Hal Sternberg, Paola A Bignone, James Murai, Nafees N Malik, Michael D West, Dana Larocca
Human pluripotent stem cells (hPSCs) can be used as a renewable source of endothelial cells for treating cardiovascular disease and other ischemic conditions. Here, we present the derivation and characterization of a panel of distinct clonal embryonic endothelial progenitor cells (eEPCs) lines that were differentiated from human embryonic stem cells (hESCs). The hESC line, ESI-017, was first partially differentiated to produce candidate cultures from which eEPCs were cloned. Endothelial cell identity was assessed by transcriptomic analysis, cell surface marker expression, immunocytochemical marker analysis, and functional analysis of cells and exosomes using vascular network forming assays...
October 13, 2023: Biomedicines
https://read.qxmd.com/read/37871215/a-degron-based-approach-to-manipulate-eomes-functions-in-the-context-of-the-developing-mouse-embryo
#16
JOURNAL ARTICLE
Alexandra M Bisia, Ita Costello, Maria-Eleni Xypolita, Luke T G Harland, Philipp J Kurbel, Elizabeth K Bikoff, Elizabeth J Robertson
The T-box transcription factor Eomesodermin (Eomes), also known as Tbr2, plays essential roles in the early mouse embryo. Loss-of-function mutant embryos arrest at implantation due to Eomes requirements in the trophectoderm cell lineage. Slightly later, expression in the visceral endoderm promotes anterior visceral endoderm formation and anterior-posterior axis specification. Early induction in the epiblast beginning at day 6 is necessary for nascent mesoderm to undergo epithelial to mesenchymal transition (EMT)...
October 31, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37857295/potentials-of-endothelial-colony-forming-cells-applications-in-hemostasis-and-thrombosis-disorders-from-unveiling-disease-pathophysiology-to-cell-therapy
#17
JOURNAL ARTICLE
Nadine Schwarz, Hamideh Yadegari
Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells circulating in a limited number in peripheral blood. They can give rise to mature endothelial cells (ECs) and, with intrinsically high proliferative potency, contribute to forming new blood vessels and restoring the damaged endothelium in vivo. ECFCs can be isolated from peripheral blood or umbilical cord and cultured to generate large amounts of autologous ECs in vitro. Upon differentiation in culture, ECFCs are excellent surrogates for mature ECs showing the same phenotypic, genotypic, and functional features...
October 2023: Hämostaseologie
https://read.qxmd.com/read/37853851/effects-of-graphene-oxide-and-reduced-graphene-oxide-nanomaterials-on-porcine-endothelial-progenitor-cells
#18
JOURNAL ARTICLE
Alberto Polo-Montalvo, Mónica Cicuéndez, Laura Casarrubios, Nathalie Barroca, Daniela da Silva, María José Feito, Rosalía Diez-Orejas, María Concepción Serrano, Paula A A P Marques, María Teresa Portolés
Graphene oxide (GO) and reduced graphene oxide (rGO) have been widely used in the field of tissue regeneration and various biomedical applications. In order to use these nanomaterials in organisms, it is imperative to possess an understanding of their impact on different cell types. Due to the potential of these nanomaterials to enter the bloodstream, interact with the endothelium and accumulate within diverse tissues, it is highly relevant to probe them when in contact with the cellular components of the vascular system...
October 19, 2023: Nanoscale
https://read.qxmd.com/read/37851174/molecular-tracking-of-interactions-between-progenitor-and-endothelial-cells-via-raman-and-ftir-spectroscopy-imaging-a-proof-of-concept-of-a-new-analytical-strategy-for-in-vitro-research
#19
JOURNAL ARTICLE
Karolina Augustyniak, Aleksandra Pragnaca, Monika Lesniak, Marta Halasa, Agata Borkowska, Ewa Pieta, Wojciech M Kwiatek, Claudine Kieda, Robert Zdanowski, Kamilla Malek
Circulating endothelial cell progenitors originating from the bone marrow are considered to be a powerful tool in the repair of endothelium damage. Due to their unique properties, endothelial progenitors are now broadly investigated to assess their clinical significance in diseases e.g., associated with brain endothelial dysfunction. However, their distinction in terms of the expression of specific markers remains ambiguous. Additionally, endothelial progenitor cells may change their repertoire of markers depending on the microenvironment of the tissue in which they are currently located...
October 18, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37818607/netrin-1-directs-vascular-patterning-and-maturity-in-the-developing-kidney
#20
JOURNAL ARTICLE
Samuel E Honeycutt, Pierre-Emmanuel Y N'Guetta, Deanna M Hardesty, Yubin Xiong, Shamus L Cooper, Matthew J Stevenson, Lori L O'Brien
The kidneys intricate vascular system supports body fluid and organ homeostasis. However, little is known about how vascular architecture is established during kidney development. More specifically, how signals from the kidney influence vessel maturity and patterning remains poorly understood. Netrin-1 (Ntn1) is a secreted ligand critical for vessel and neuronal guidance. Here, we demonstrate that Ntn1 is expressed by Foxd1+ stromal progenitors in the developing kidney and conditional deletion (Foxd1GC/+;Ntn1fl/fl) results in hypoplastic kidneys with extended nephrogenesis...
October 11, 2023: Development
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