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https://www.readbyqxmd.com/read/27824658/influences-of-resistance-training-on-physical-function-in-older-obese-men-and-women-with-sarcopenia
#1
Katja Stoever, Anke Heber, Sabine Eichberg, Klara Brixius
BACKGROUND AND PURPOSE: Sarcopenic obesity is associated with disability, gait problems, and falls. Activities of daily living such as walking and climbing stairs are physically difficult or impossible for the individual with severe obesity. These aspects also limit participation in recreational activities or exercise programs. However, good muscle function is crucial to maintain functional independence. The objective of this study was to investigate the influence of resistance training on physical function in older, obese persons with sarcopenia...
November 7, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27605230/coxibrain-results-of-the-prospective-randomised-phase-ii-iii-study-for-the-selective-cox-2-inhibition-in-chronic-subdural-haematoma-patients
#2
A Schaumann, W Klene, Chr Rosenstengel, F Ringel, J Tüttenberg, P Vajkoczy
BACKGROUND: Chronic subdural haematomas (cSDHs) have shown an increasing incidence in an ageing population over the last 20 years, while unacceptable recurrence rates of up to 30 % persist. The recurrence rate of cSDH seems to be related to the excessive neoangiogenesis in the parietal membrane, which is mediated via vascular endothelial growth factor (VEGF). This is found to be elevated in the haematoma fluid and is dependent on eicosanoid/prostaglandin and thromboxane synthesis via cyclo-oxygenase-2 (COX-2)...
November 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27508801/-op-lb-02-05-a-patient-with-malignant-hypertension-successfully-treated-with-eculizumab-and-bosentan-suggestions-of-significant-interactions-of-complement-and-the-endothelin-system-in-blood-pressure-control
#3
A Mitchell, B Nokay, H Guberina, U Behlen-Wilm, M Nagel, M Kirschfink, T Wiech, A Kribben, A Bienholz
OBJECTIVE: Malignant hypertension as borne out by uncontrolled hypertension with accelerated target organ damage has a variable and often dire prognosis. Loss of kidney function is a hallmark of the condition and is frequently accompanied by thrombotic microangiopathy (TMA). DESIGN AND METHOD: Here we present the case of a patient with malignant hypertension, who was successfully treated using a combination of in-label and off-label medication according to the following pathophysiological concepts: 1) Innate immunity has been identified as a player in blood pressure (BP) control, 2) the complement inhibitor eculizumab has become available for treating atypical hemolytic uremic syndrome (aHUS), which shares many features of malignant hypertension, 3) endothelin (ET) antagonism, although not currently approved for these indications, has been shown to be effective for treating proteinuria and as a possible adjunct for the treatment of resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27075679/-conservative-treatment-of-nonspecific-chronic-low-back-pain-evidence-of-the-efficacy-a-systematic-literature-review
#4
J Bredow, K Bloess, J Oppermann, C K Boese, L Löhrer, P Eysel
OBJECTIVES: Non-specific chronic low back pain (NSCLBP): Which conservative therapy shows an evident effectiveness - A review of the current literature. MATERIALS AND METHODS: Our results are based on literature reviews of current randomised control studies, reviews and meta-analysis drawn from the Cochrane Library and Medline-Database between the years 2004 until 2015. German and English Studies were included. We focused on different conservative Treatments of NSCLBP, which are listed at, the NVL-Guidelines...
July 2016: Der Orthopäde
https://www.readbyqxmd.com/read/26793863/cephalometric-features-of-class-iii-malocclusion
#5
Georgeta Zegan, Cristina Dascălu, R B Mavru, Daniela Anistoroaei
AIM: The study aimed to identify quantitative and relational characteristics of bone, dental and soft tissue structures for Class III malocclusion, according to gender and age range. MATERIAL AND METHODS: 60 conventional lateral cephalograms were divided into two groups according to ANB angle: the group of cases with skeletal Class III (n = 36) and a control group with skeletal Class I (n = 24). There were performed 53 digital cephalometric measurements according to Steiner, Tweed and Jarabak analyzes...
October 2015: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/26638513/-acute-pericarditis
#6
M Ben Gaied, J Krähenbühl, F Rey, D Genné
Acute pericarditis is an inflammation of the pericardium. Different etiologies are known, and can be classified in three groups: infectious, neoplastic and auto-immun. The diagnosis is based essentially on clinical signs and should be raised by position and respiratory dependent chest pain, especially when it follows a viral infection, and a pericardial friction rub on cardiac auscultation. An ECG and an echocardiography should be performed to assess the presence of a pericardial effusion. A diffuse and concave ST elevation permits the distinction with myocardial ischemia...
October 7, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26528732/cranial-base-characteristics-in-anteroposterior-malocclusions-a-meta-analysis
#7
Aixiu Gong, Jing Li, Zhendong Wang, Yuan Li, Fang Hu, Qingyi Li, Dengshun Miao, Lin Wang
OBJECTIVE: To investigate cranial base characteristics in malocclusions with sagittal discrepancies. MATERIALS AND METHODS: An electronic search was performed in PubMed, Embase, Web of Science, and the Cochrane Library. A fixed- or random-effect model was applied to calculate weighted mean difference with 95% confidence intervals (CIs) according to statistical heterogeneity. Outcome measures were anterior, posterior, and total cranial base length and cranial base angle...
July 2016: Angle Orthodontist
https://www.readbyqxmd.com/read/25929893/-asa-intolerance-syndrome-and-persistent-rhinosinusitis-differential-diagnosis-and-treatment
#8
H Kirsche, L Klimek
BACKGROUND: A differential diagnosis of persistent chronic rhinosinusitis is ASA-intolerance syndrome (AIS), also known as Aspirin®‑exacerbated respiratory disease (AERD), Samter-Trias (Samter's disease, Morbus Widal). Particularly in cases of frequent recurrency of nasal polyps in combination with bronchial asthma and hypersensitivity reactions to acetylsalicylic acid (ASA) and other nonsteroidal anti-inflammatory drugs (NSAR) can often be referred to an underlying AIS. The pathogenesis of this syndrome is attributed to a misallocation of the arachidonic acid metabolism, resulting in an increased leukotriene production...
May 2015: HNO
https://www.readbyqxmd.com/read/25792266/dietary-exposure-to-volatile-and-non-volatile-n-nitrosamines-from-processed-meat-products-in-denmark
#9
S S Herrmann, L Duedahl-Olesen, T Christensen, P T Olesen, K Granby
Recent epidemiological studies show a positive association between cancer incidence and high intake of processed meat. N-nitrosamines (NAs) in these products have been suggested as one potential causative factor. Most volatile NAs (VNAs) are classified as probable human carcinogens, whereas the carcinogenicity for the majority of the non-volatile NA (NVNA) remains to be elucidated. Danish adults (15-75 years) and children (4-6 years) consume 20 g and 16 g of processed meat per day (95th percentile), respectively...
June 2015: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/25658333/urinary-levels-of-n-nitroso-compounds-in-relation-to-risk-of-gastric-cancer-findings-from-the-shanghai-cohort-study
#10
Ling Xu, Yong-Hua Qu, Xin-Di Chu, Renwei Wang, Heather H Nelson, Yu-Tang Gao, Jian-Min Yuan
BACKGROUND: N-Nitroso compounds are thought to play a significant role in the development of gastric cancer. Epidemiological data, however, are sparse in examining the associations between biomarkers of exposure to N-nitroso compounds and the risk of gastric cancer. METHODS: A nested case-control study within a prospective cohort of 18,244 middle-aged and older men in Shanghai, China, was conducted to examine the association between urinary level of N-nitroso compounds and risk of gastric cancer...
2015: PloS One
https://www.readbyqxmd.com/read/25515122/-clinical-otorhinolaryngological-symptoms-of-metamizole-induced-agranulocytosis
#11
T Send, S Westermann, K W G Eichhorn, M Jakob
BACKGROUND: Despite the controversial international debate on the use of metamizole as a standard analgesic, the prescription figures for Germany have increased constantly during recent years. However, metamizole can lead to the rare and severe medical condition called agranulocytosis. MATERIALS AND METHODS: Between January 2009 and January 2014, 5 patients with metamizole-induced agranulocytosis presented themselves at the Interdisciplinary Emergency Center of the University Clinic Bonn...
March 2015: HNO
https://www.readbyqxmd.com/read/25154692/-bloody-diarrhoea-causes-diagnostics-and-therapy
#12
REVIEW
Henriette Heinrich, Stephan R Vavricka
Bloody diarrhoea is always a warning sign and should prompt a more thorough history on duration and accompanying symptoms as well as current medications (antibiotics, NSAR) and diseases (HIV, IBD, transplant organ recipients). In this review the most common bacterial, viral and parasitical causes of bloody diarrhoea as well as radiation and ischemic colitis will be discussed. Additionally important diagnostic tools such as stool cultures and calprotectin for infectious causes auf diarrhoea and imaging tools (CT and endoscopy) for ischemic disease are presented...
September 2014: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/25143931/evaluation-of-relationship-between-cranial-base-angle-and-maxillofacial-morphology-in-indian-population-a-cephalometric-study
#13
Amit Bhattacharya, Amarjitsingh Bhatia, Dolly Patel, Nishit Mehta, Harshik Parekh, Rahul Trivedi
OBJECTIVE: To investigate the role played by the cranial base flexure in influencing the sagittal and vertical position of the jaws in Indian population. MATERIALS AND METHODS: Lateral cephalograms of 108 subjects were divided into three categories (Group A: NSAr > 125°, Group B: NSAr-120°-125°, Group C: NSAr < 120°) according to value of NSAr. Measurement of eight angular (SNA, SNB, NPg-FH, ANB, NAPg, SN-GoGn, Y-Axis, ArGo-SN) and seven linear (N-S, S-Ar, Ar-N, Ar-Pt A, Ar-Gn, Wits appraisal, N- Pt A) variables were taken...
July 2014: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/25039106/a-cephalometric-analysis-of-the-cranial-base-and-frontal-part-of-the-face-in-patients-with-mandibular-prognathism
#14
COMPARATIVE STUDY
Tatjana Cutović, Nebojsa Jović, Ljiljana Stojanović, Julija Radojicić, Irena Mladenović, Stevo Matijević, Ruzica Kozomara
BACKGROUND/AIM: The literature suggests different views on the correlation between the cranial base morphology and size and saggital intermaxillary relationships. The aim of this study was to investigate the cranial base morphology, including the frontal facial part in patients with mandibular prognathism, to clarify a certain ambiguities, in opposing viewspoints in the literature. METHODS: Cephalometric radiographies of 60 patients were analyzed at the Dental Clinic of the Military Medical Academy, Belgrade, Serbia...
June 2014: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/24955846/role-of-an-active-site-loop-in-the-promiscuous-activities-of-amycolatopsis-sp-t-1-60-nsar-osbs
#15
Andrew W McMillan, Mariana S Lopez, Mingzhao Zhu, Benjamin C Morse, In-Cheol Yeo, Jaleesia Amos, Ken Hull, Daniel Romo, Margaret E Glasner
The o-succinylbenzoate synthase (OSBS) family is part of the functionally diverse enolase superfamily. Many proteins in one branch of the OSBS family catalyze both OSBS and N-succinylamino acid racemization in the same active site. In some promiscuous NSAR/OSBS enzymes, NSAR activity is biologically significant in addition to or instead of OSBS activity. Identifying important residues for each reaction could provide insight into how proteins evolve new functions. We have made a series of mutations in Amycolatopsis sp...
July 15, 2014: Biochemistry
https://www.readbyqxmd.com/read/24937446/promiscuity-of-exiguobacterium-sp-at1b-o-succinylbenzoate-synthase-illustrates-evolutionary-transitions-in-the-osbs-family
#16
Ashley M Brizendine, Denis Odokonyero, Andrew W McMillan, Mingzhao Zhu, Ken Hull, Daniel Romo, Margaret E Glasner
Catalytic promiscuity, which is the ability to catalyze more than one reaction in the same active site, is thought to facilitate the evolution of new protein functions. Although many enzymes are catalytically promiscuous, there is little direct evidence to show how promiscuous activities evolved into biological functions. We are seeking evidence for this model by studying the o-succinylbenzoate synthase (OSBS) family. Most enzymes within this family only catalyze OSBS, which is a step in menaquinone synthesis...
July 18, 2014: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/24872444/loss-of-quaternary-structure-is-associated-with-rapid-sequence-divergence-in-the-osbs-family
#17
Denis Odokonyero, Ayano Sakai, Yury Patskovsky, Vladimir N Malashkevich, Alexander A Fedorov, Jeffrey B Bonanno, Elena V Fedorov, Rafael Toro, Rakhi Agarwal, Chenxi Wang, Nicole D S Ozerova, Wen Shan Yew, J Michael Sauder, Subramanyam Swaminathan, Stephen K Burley, Steven C Almo, Margaret E Glasner
The rate of protein evolution is determined by a combination of selective pressure on protein function and biophysical constraints on protein folding and structure. Determining the relative contributions of these properties is an unsolved problem in molecular evolution with broad implications for protein engineering and function prediction. As a case study, we examined the structural divergence of the rapidly evolving o-succinylbenzoate synthase (OSBS) family, which catalyzes a step in menaquinone synthesis in diverse microorganisms and plants...
June 10, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/23841297/-longitudinal-genetic-effects-on-mandibular-position-of-female-twins-from-six-to-twelve-years-old
#18
Chang-feng Zhu, Jing Peng
OBJECTIVE: To find the longitudinal genetic effects on mandibular position in mixed dentition. METHODS: The sample used in this study consisted of lateral cephalograms of eighty-nine pairs of female twins in Beijing. With a mixed longitudinal method, the effective twins were 183 pairs(monozygous 110 pairs and dizygous 73 ones). The genetic and environmental effects on mandibular position were analyzed by statistical methods in female twins from six to twelve years old...
June 2013: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/23492784/fieber-n%C3%A3-tzliches-oder-sch%C3%A3-dliches-zu-behandelndes-symptom
#19
Schaffner
Fever is a phylogenetically ancient host reaction to invading microorganisms and other noxious stimuli. Poikylothermic organisms can reach febrile temperatures by seeking a hot environment in response to a higher set point in their thermoregulatory center. Endothermic organisms produce febrile temperatures through endogenous heat production at the expenditure of a higher metabolic rate. Nevertheless, fever has been conserved during evolution through millennia, obviously because of its advantage for host defense...
March 1, 2006: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/23325301/synthesis-and-structural-studies-on-thioimides-r2c-nsr-and-sulfur-diimides-r2c-nsn-cr2
#20
Rebecca L Melen, Dana J Eisler, Rachel A Hewitt, Jeremy M Rawson
Reaction of Ph(2)C=O and py(2)C=O with Li[N(SiMe(3))(2)] and ArSCl (Ar = 2-O(2)NC(6)H(4), 2,4-(O(2)N)(2)C(6)H(3)) yielded Ph(2)C=NSAr (1a and 1b respectively) and py(2)C=NSAr (2a and 2b respectively). Reaction of fluorenone, C(12)H(8)C=O with Li[N(SiMe(3))(2)] and ArSCl under similar conditions afforded C(12)H(8)CNSAr (3a and 3b respectively). Whilst reaction of fluorenone with Li[N(SiMe(3))(2)] and SCl(2) in a 2 : 2 : 1 ratio afforded the sulfur-diimide, C(12)H(8)CNSNCC(12)H(8) (4), reaction of py(2)C=O with Li[N(SiMe(3))(2)] and SCl(2) under similar conditions afforded the thiazyl heterocycle [py(2)CNS]Cl (5) via intramolecular coordination...
March 21, 2013: Dalton Transactions: An International Journal of Inorganic Chemistry
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