keyword
https://read.qxmd.com/read/38407915/heat-exposure-preterm-birth-and-the-role-of-greenness-in-australia
#21
JOURNAL ARTICLE
Tingting Ye, Yuming Guo, Wenzhong Huang, Yiwen Zhang, Michael J Abramson, Shanshan Li
IMPORTANCE: Preterm birth (PTB) is associated with adverse health outcomes. The outcomes of heat exposure during pregnancy and the moderating association of greenness with PTB remain understudied. OBJECTIVE: To investigate associations between heat exposure, greenness, and PTB, as well as interactions between these factors. DESIGN, SETTING, AND PARTICIPANTS: Included in this cohort study were births occurring in Sydney, New South Wales, Australia, between 2000 and 2020, retrieved from New South Wales Midwives Data Collection...
February 26, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38400668/access-to-innovative-therapies-in-pediatric-oncology-report-of-the-nationwide-experience-in-canada
#22
JOURNAL ARTICLE
Sandra Judd, Gabriel Revon-Riviere, Stephanie A Grover, Rebecca J Deyell, Magimairajan Issai Vanan, Victor A Lewis, Lucie Pecheux, Alexandra P Zorzi, Catherine Goudie, Raoul Santiago, Thai Hoa Tran, Lesleigh S Abbott, Josee Brossard, Paul Moorehead, Saima Alvi, Carol Portwine, Avram Denburg, James A Whitlock, Sarah Cohen-Gogo, Daniel A Morgenstern
BACKGROUND: The need for new therapies to improve survival and outcomes in pediatric oncology along with the lack of approval and accessible clinical trials has led to "out-of-trial" use of innovative therapies. We conducted a retrospective analysis of requests for innovative anticancer therapy in Canadian pediatric oncology tertiary centers for patients less than 30 years old between 2013 and 2020. METHODS: Innovative therapies were defined as cancer-directed drugs used (a) off-label, (b) unlicensed drugs being used outside the context of a clinical trial, or (c) approved drugs with limited evidence in pediatrics...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38398378/new-perspectives-of-therapies-in-osteogenesis-imperfecta-a-literature-review
#23
REVIEW
Alexandru Dinulescu, Alexandru-Sorin Păsărică, Mădălina Carp, Andrei Dușcă, Irina Dijmărescu, Mirela Luminița Pavelescu, Daniela Păcurar, Alexandru Ulici
(1) Background: Osteogenesis imperfecta (OI) is a rare skeletal dysplasia characterized as a heterogeneous disorder group with well-defined phenotypic and genetic features that share uncommon bone fragility. The current treatment options, medical and orthopedic, are limited and not efficient enough to improve the low bone density, bone fragility, growth, and mobility of the affected individuals, creating the need for alternative therapeutic agents. (2) Methods: We searched the medical database to find papers regarding treatments for OI other than conventional ones...
February 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38397996/addressing-a-pre-clinical-pipeline-gap-development-of-the-pediatric-acute-myeloid-leukemia-patient-derived-xenograft-program-at-texas-children-s-hospital-at-baylor-college-of-medicine
#24
JOURNAL ARTICLE
Alexandra M Stevens, Maci Terrell, Raushan Rashid, Kevin E Fisher, Andrea N Marcogliese, Amos Gaikwad, Pulivarthi Rao, Chelsea Vrana, Michael Krueger, Michael Loken, Andrew J Menssen, Jacqueline A Cook, Noah Keogh, Michelle Alozie, Hailey Oviedo, Alan K Gonzalez, Tamilini Ilangovan, Julia Kim, Sohani Sandhu, Michele S Redell
The survival rate of pediatric acute myeloid leukemia (pAML) is currently around 60%. While survival has slowly increased over the past few decades, the development of novel agents likely to further improve survival for this heterogeneous patient population has been limited by gaps in the pAML pre-clinical pipeline. One of the major hurdles in evaluating new agents for pAML is the lack of pAML patient-derived xenograft (PDX) models. Unlike solid tumors and other types of leukemias, AML is notoriously hard to establish in mouse models, likely due in part to the need for specific human microenvironment elements...
February 8, 2024: Biomedicines
https://read.qxmd.com/read/38396377/guidelines-for-outpatient-administration-of-naxitamab-experience-from-atrium-health-levine-children-s-hospital
#25
JOURNAL ARTICLE
Erin Murphy Trovillion, Meghan Michael, Cathryn C Jordan, Lauren Brown, Katlin Phillips, Javier Oesterheld, Giselle Saulnier-Sholler
AIM: In this publication, we will share our experience of AE management, provide guidance for appropriate staffing, and the discuss the importance of patient education when treating patients with R/R HR neuroblastoma using naxitamab. BACKGROUND: Approved treatments for patients with refractory and/or relapsed (R/R) high-risk (HR) neuroblastoma are limited, and there is a high unmet need for new treatment combinations. Naxitamab is a disialoganglioside 2 (GD2)-binding antibody that was approved by the United States Food and Drug Administration in 2020 for use in combination with granulocyte-macrophage colony-stimulating factor for the treatment of patients with R/R HR neuroblastoma in the bone and/or bone marrow and who have demonstrated a partial response, minor response, or stable disease with prior therapy...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38392585/semi-automatic-analysis-of-specific-electroencephalographic-patterns-during-nrem2-sleep-in-a-pediatric-population-after-sars-cov-2-infection
#26
JOURNAL ARTICLE
Paolo Di Bella, Anna Gaia Attardi, Ambra Butera, Arianna Mancini, Nunzia Calabrò, Elisa Giuseppa Lo Re, Giuseppe Trimarchi, Antonio Gennaro Nicotera, Gabriella Di Rosa, Daniela Lo Giudice
The post-COVID-19 condition is defined by the World Health Organization as the persistence of symptoms or development of new symptoms three months after the initial SARS-CoV-2 infection, lasting for at least two months without a clear explanation. Neuropsychiatric disorders associated with this condition include asthenia, memory and concentration problems, and sleep disturbances. Our study aims to investigate sleep patterns following SARS-CoV-2 infection using EEG findings and a sleep quality questionnaire completed by parents (Sleep Disturbance Scale for Children-SDSC)...
January 30, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38390344/prefabricated-zirconia-crowns-and-preformed-metal-crowns-in-the-treatment-of-severely-childhood-caries-and-anterior-crossbite-in-a-child-with-autistic-spectrum-disorder
#27
Shuman Deng, Qi Gao, Li Zhang, Jing Xie, Ying Chen, Xuezhen Peng
Crowns have been recommended to treat decayed teeth and rebuild teeth function. The dental management of children with autism is a tremendous challenge for pediatric dentists due to the impaired behaviors and communication disorders. In this context, a 5-year-old boy with autism was treated to solve carious lesions under the assistance of general anesthesia. The posterior occlusal function was restored, and the crossbite existing in the primary anterior teeth was approached merely by NuSmile® zirconia crowns (ZCs) rather than orthodontic intervention...
2024: Case Reports in Dentistry
https://read.qxmd.com/read/38385144/post-intensive-care-syndrome-recent-advances-and-future-directions
#28
REVIEW
Shigeaki Inoue, Nobuto Nakanishi, Fumimasa Amaya, Yoshihisa Fujinami, Junji Hatakeyama, Toru Hifumi, Yuki Iida, Daisuke Kawakami, Yusuke Kawai, Yutaka Kondo, Keibun Liu, Kensuke Nakamura, Takeshi Nishida, Hidenori Sumita, Shunsuke Taito, Shunsuke Takaki, Norihiko Tsuboi, Takeshi Unoki, Yasuyo Yoshino, Osamu Nishida
Post-intensive care syndrome comprises physical, cognitive, and mental impairments in patients treated in an intensive care unit (ICU). It occurs either during the ICU stay or following ICU discharge and is related to the patients' long-term prognosis. The same concept also applies to pediatric patients, and it can greatly affect the mental status of family members. In the 10 years since post-intensive care syndrome was first proposed, research has greatly expanded. Here, we summarize the recent evidence on post-intensive care syndrome regarding its pathophysiology, epidemiology, assessment, risk factors, prevention, and treatments...
2024: Acute Medicine & Surgery
https://read.qxmd.com/read/38383310/a-stool-based-qpcr-for-the-diagnosis-of-tb-in-children-and-people-living-with-hiv-in-uganda-eswatini-and-mozambique-stool4tb-a-protocol-for-a-multicenter-diagnostic-evaluation
#29
JOURNAL ARTICLE
Lucia Carratala-Castro, Willy Ssengooba, Alex Kay, Sozinho Acácio, Joanna Ehrlich, Andrew R DiNardo, Nosisa Shiba, Joachim K Nsubuga, Shilzia Munguambe, Belén Saavedra-Cervera, Patricia Manjate, Durbbin Mulengwa, Busizwe Sibandze, Mangaliso Ziyane, George Kasule, Edson Mambuque, Moorine Penninah Sekadde, Eric Wobudeya, Moses L Joloba, Jan Heyckendorf, Christoph Lange, Sabine Hermans, Anna Mandalakas, Alberto L García-Basteiro, Elisa Lopez-Varela
BACKGROUND: Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk of mortality, particularly in the absence of rapid diagnosis. The main challenges of diagnosing TB in these populations are due to the unspecific and paucibacillary disease presentation and the difficulty of obtaining respiratory samples. Thus, novel diagnostic strategies, based on non-respiratory specimens could improve clinical decision making and TB outcomes in high burden TB settings...
February 21, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38377775/clinical-trial-inclusion-in-patients-with-relapsed-refractory-neuroblastoma-following-the-european-precision-cancer-medicine-trial-mappyacts
#30
JOURNAL ARTICLE
Jordane Chaix, Gudrun Schleiermacher, Nadège Corradini, Nicolas André, Estelle Thebaud, Marion Gambart, Anne-Sophie Defachelles, Natacha Entz-Werle, Pascal Chastagner, Émilie De Carli, Stéphane Ducassou, Judith Landman-Parker, Tiphaine Adam-de-Beaumais, Alicia Larive, Stefan Michiels, Gilles Vassal, Dominique Valteau-Couanet, Birgit Geoerger, Pablo Berlanga
INTRODUCTION: Despite poor survival for patients with relapsed or refractory neuroblastoma, only 10-16% of patients are reported to be included in early phase trials. This study aimed to explore the impact of molecular profiling within the prospective precision cancer medicine trial MAPPYACTS (NCT02613962) on subsequent early phase trial recruitment and treatment by matched targeted therapies in this population. METHODS AND MATERIALS: Clinical data from all French patients with relapsed/refractory neuroblastoma enrolled in MAPPYACTS were analyzed for subsequent matched/non-matched targeted treatment based on clinical tumor board (CMTB) recommendations...
April 2024: European Journal of Cancer
https://read.qxmd.com/read/38365198/pgap2-related-hyperphosphatasia-mental-retardation-syndrome-report-of-a-novel-patient-toward-a-broadening-of-phenotypic-spectrum-and-therapeutic-perspectives
#31
JOURNAL ARTICLE
Annalisa Saracino, Martina Totaro, Davide Politano, Valentina DE Giorgis, Simone Gana, Grazia Papalia, Anna Pichiecchio, Massimo Plumari, Elisa Rognone, Costanza Varesio, Simona Orcesi
PGAP2 gene has been known to be the cause of "hyperphosphatasia, mental retardation syndrome-3" (HPMRS3). To date, 14 pathogenic variants in PGAP2 have been identified as the cause of this syndrome in 24 patients described in single-case reports or small clinical series with pan-ethnic distribution. We aim to present a pediatric PGAP2 -mutated case, intending to further expand the clinical phenotype of the syndrome and to report our experience on a therapeutic approach to drug-resistant epilepsy.We present the clinical, neuroradiological, and genetic characterization of a Caucasian pediatric subject with biallelic pathogenic variants in the PGAP2 gene revealed by next generation sequencing analysis...
February 16, 2024: Neuropediatrics
https://read.qxmd.com/read/38359080/is-allergen-immunotherapy-a-model-of-personalized-treatment-in-pediatric-respiratory-allergy
#32
JOURNAL ARTICLE
Gustavo Falbo Wandalsen, Fernando Monteiro Aarestrup, Dirceu Solé
PURPOSE OF REVIEW: To review recent evidence on allergen immunotherapy (AIT) as a model of personalized medicine in the treatment of children and adolescents with respiratory allergies. RECENT FINDINGS: Meta-analysis and systematic review studies continue to point out that AIT is an effective treatment for children with respiratory allergies. Molecular allergy allows the understanding of patient sensitization profiles that frequently change the prescription of AIT...
April 1, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38358956/old-tools-new-applications-use-of-environmental-bacteriophages-for-typhoid-surveillance-and-evaluating-vaccine-impact
#33
JOURNAL ARTICLE
Yogesh Hooda, Shuborno Islam, Rathin Kabiraj, Hafizur Rahman, Himadree Sarkar, Kesia E da Silva, Rajan Saha Raju, Stephen P Luby, Jason R Andrews, Samir K Saha, Senjuti Saha
Typhoid-conjugate vaccines (TCVs) provide an opportunity to reduce the burden of typhoid fever, caused by Salmonella Typhi, in endemic areas. As policymakers design vaccination strategies, accurate and high-resolution data on disease burden is crucial. However, traditional blood culture-based surveillance is resource-extensive, prohibiting its large-scale and sustainable implementation. Salmonella Typhi is a water-borne pathogen, and here, we tested the potential of Typhi-specific bacteriophage surveillance in surface water bodies as a low-cost tool to identify where Salmonella Typhi circulates in the environment...
February 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38358393/considering-functional-outcomes-as-efficacy-endpoints-in-pediatric-low-grade-glioma-clinical-trials-an-fda-educational-symposium
#34
JOURNAL ARTICLE
Jason Fangusaro, Robert A Avery, Michael J Fisher, Roger J Packer, Karin S Walsh, Antoinette Schouten-van Meeteren, Dominik Karres, Diana Bradford, Vishal Bhatnagar, Harpreet Singh, Paul G Kluetz, Martha Donoghue, Elizabeth S Duke
In October 2022, the Food and Drug Administration (FDA) Oncology Center of Excellence (OCE) hosted an educational symposium entitled, "Considering Functional Outcomes as Efficacy Endpoints in Pediatric Low-Grade Glioma (pLGG) Clinical Trials." The symposium brought together patient advocates, regulators from the FDA and the European Medicines Agency (EMA), and an international group of academic thought leaders in the field of pediatric neuro-oncology to discuss the potential role of functional outcomes, including visual acuity, motor function, and neurocognitive performance, as endpoints in clinical trials enrolling patients with pLGG...
February 15, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38357207/implementing-data-on-targeted-therapy-from-the-inform-registry-platform-for-children-with-relapsed-cancer-in-sweden
#35
JOURNAL ARTICLE
Sofia Wallin, Ingrid Øra, Gabriela Prochazka, Johanna Sandgren, Caroline Björklund, Gustaf Ljungman, Hartmut Vogt, Torben Ek, Cornelis M van Tilburg, Anna Nilsson
BACKGROUND: Advances in treatment of childhood malignancies have improved overall cure rates to 80%. Nevertheless, cancer is still the most common cause of childhood mortality in Sweden. The prognosis is particularly poor for relapse of high-risk malignancies. In the international INFORM registry, tumor tissue from patients with relapsed, refractory, or progressive pediatric cancer as well as from very-high risk primary tumors is biologically characterized using next-generation sequencing to identify possible therapeutic targets...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38353586/association-of-an-in-hospital-desirability-of-outcomes-ranking-scale-with-postdischarge-health-related-quality-of-life-a-secondary-analysis-of-the-life-after-pediatric-sepsis-evaluation
#36
JOURNAL ARTICLE
Grace E Logan, Russell K Banks, Ron Reeder, Kristen Miller, Peter M Mourani, Tellen D Bennett, Stephanie L Bourque, Kathleen L Meert, Jerry Zimmerman, Aline B Maddux
OBJECTIVES: To develop a desirability of outcome ranking (DOOR) scale for use in children with septic shock and determine its correlation with a decrease in 3-month postadmission health-related quality of life (HRQL) or death. DESIGN: Secondary analysis of the Life After Pediatric Sepsis Evaluation prospective study. SETTING: Twelve U.S. PICUs, 2013-2017. PATIENTS: Children (1 mo-18 yr) with septic shock. INTERVENTIONS: None...
February 14, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38351155/pediatric-spinal-ependymoma-with-chromothripsis-of-chromosome-6-a-case-report-and-review-of-the-literature
#37
REVIEW
Keela R Scott, Melissa A Gener, Elena A Repnikova
BACKGROUND: Ependymomas are the third most common central nervous system tumor in the pediatric population; however, spinal ependymomas in children are rare. Ependymomas affecting the spinal cord most frequently occur in adults of 20-40 years of age. The current World Health Organization classification system for ependymomas is now composed of ten different entities based on histopathology, location, and molecular studies, with evidence that the new classification system more accurately predicts clinical outcomes...
February 14, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38347822/characteristics-of-pediatric-hospital-medicine-fellowship-program-directors
#38
JOURNAL ARTICLE
Margaret J Trost, Ann H Allen, Monique Naifeh, Ashlie Tseng, Allyson McDermott, Snehal Shah, Jeffrey C Winer, Erik Hoefgen, Joanna Thomson, Robert A Dudas
BACKGROUND AND OBJECTIVES: Rapid growth in pediatric hospital medicine (PHM) fellowships has occurred, yielding many new program directors (PDs). Characteristics of PDs have potential implications on the field. To describe characteristics (demographic, educational) and scholarly interests of PHM fellowship PDs. METHODS: We developed and distributed a 15-question, cross-sectional national survey to the PHM PDs listserv. Questions were pilot tested. The survey was open for 4 weeks with weekly reminders...
February 13, 2024: Hospital Pediatrics
https://read.qxmd.com/read/38344334/the-management-of-clostridioides-difficile-infection-from-empirism-to-evidence
#39
REVIEW
Ioana Ş Deac, Adriana M Ofrim, Radu A Fărcaş, Simona Grad, Ştefan Lucian Popa, Dan L Dumitraşcu
Clostridioides difficile infection (CDI) in clinical practice represents a challenge for its management and also prevention of recurrence. Even though there are updated guidelines for infection prevention, control and treatment, CDI remains a leading cause of healthcare acquired diarrhea with increasing incidence in the community. We present here a synthesis of the most recent international guidelines on the management of CDI. In 2021 updated guidelines on the treatment of CDI in adults were published by the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA), American College of Gastroenterology (ACG) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)...
January 2024: Medicine and pharmacy reports
https://read.qxmd.com/read/38343491/idiopathic-toxic-epidermal-necrolysis-in-a-pediatric-patient
#40
Sharon Pan, Julie Boisen, Saadeddine Saad
Stevens-Johnson syndrome and toxic epidermal necrolysis are potentially life-threatening cutaneous diseases that are rarely seen in the pediatric population. We describe a case of a 7-year-old female who presented with fever, cough, mucosal erosions, and a widespread maculopapular eruption with flaccid bullae for 4 days. She had no sick contacts and no new medications, supplements, or vitamins. She then rapidly developed ulcerations in her oral mucosa and genital area, numerous scattered tense bullae throughout her body, and patchy areas of desquamation...
2024: Proceedings of the Baylor University Medical Center
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