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https://www.readbyqxmd.com/read/28541278/sharing-data-under-the-21st-century-cures-act
#1
REVIEW
Mary A Majumder, Christi J Guerrini, Juli M Bollinger, Robert Cook-Deegan, Amy L McGuire
On 13 December 2016, President Obama signed the 21st Century Cures Act ("the Act") into law. Many of its provisions support the creation of an "Information Commons," an ecosystem of separate but interconnected initiatives that facilitate open and responsible sharing of genomic and other data for research and clinical purposes. For example, the Act supports the National Institutes of Health in mandating data sharing, provides funding and guidance for the large national cohort program now known as All of Us, expresses congressional support for a global pediatric study network, and strengthens patient access to health information...
May 25, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28471436/a-novel-approach-in-pediatric-telegenetic-services-geneticist-pediatrician-and-genetic-counselor-team
#2
Shobana Kubendran, Siddharthan Sivamurthy, Gerald Bradley Schaefer
PurposeOur aim was to improve access to genetic services in an underserved region by developing a collaborative telegenetic service delivery model with a pediatrician, medical geneticist, and genetics counselor (GC).MethodsProtocols for the evaluation of common genetic indications were developed. Patients referred with indications suggestive of a syndromic etiology were scheduled to see the geneticist directly via telegenetics. Other patients were scheduled to see the pediatrician and GC in person before follow-up with the geneticist if indicated...
May 4, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28377653/clinical-and-radiological-evaluation-of-turmeric-powder-as-a-pulpotomy-medicament-in-primary-teeth-an-in-vivo-study
#3
Rajiv N Purohit, Manohar Bhatt, Kanchan Purohit, Jitendra Acharya, Rajesh Kumar, Rakesh Garg
Many plants with biological and antimicrobiological properties have been studied since there has been a relevant increase in the incidence of antibiotic overuse and misuse. In dentistry, phytomedicines have been used as anti-inflammatory, antibiotic, analgesic, and sedative agents. Turmeric is used extensively in foods for its flavor and color, as well as having a long tradition of use in the Chinese and Ayurvedic systems of medicine, particularly as an anti-inflammatory and for the treatment of flatulence, jaundice, menstrual difficulties, hematuria, hemorrhage, and colic...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28334565/year-end-resident-clinic-handoffs-narrative-review-and-recommendations-for-improvement
#4
Amber T Pincavage, Michael J Donnelly, John Q Young, Vineet M Arora
BACKGROUND: Year-end clinic handoffs in resident continuity clinics are an important patient safety issue. METHODS: Intervention articles addressing the year-end resident clinic handoff were identified in a targeted literature search. These articles were reviewed and abstracted to summarize the current literature. On the basis of these reviews and consensus expert opinion, recommendations to improve year-end clinic handoffs were developed. RESULTS: Of 23 identified articles, 10 intervention articles in the fields of internal medicine, internal medicine-pediatrics, psychiatry, and family medicine were ultimately included...
February 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28321121/dnmt3a-regulates-t-cell-development-and-suppresses-t-all-transformation
#5
A C Kramer, A Kothari, W C Wilson, H Celik, J Nikitas, C Mallaney, E L Ostrander, E Eultgen, A Martens, M C Valentine, A L Young, T E Druley, M E Figueroa, B Zhang, G A Challen
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm resulting from the malignant transformation of T-cell progenitors, and comprises ~15% and 25% of pediatric and adult ALL cases, respectively. It is well-established that activating NOTCH1 mutations are the major genetic lesions driving T-ALL in most patients, but efforts to develop targeted therapies against this pathway have produced limited success in decreasing leukemic burden and come with significant clinical side effects...
April 11, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28319548/tanshinone-iia-attenuates-sevoflurane-neurotoxicity-in-neonatal-mice
#6
Yimeng Xia, Heng Xu, Chenfei Jia, Xiaodong Hu, Yu Kang, Xiaoxuan Yang, Qingsheng Xue, Guorong Tao, Buwei Yu
BACKGROUND: Sevoflurane is the most widely used inhalational anesthetic in pediatric medicine. Despite this, sevoflurane has been reported to exert potentially neurotoxic effects on the developing brain. Clinical interventions and treatments for these effects are limited. Tanshinone IIA (Tan IIA), extracted from Salvia miltiorrhiza (Danshen), has been documented to alleviate cognitive decline in traditional applications. Therefore, we hypothesized that preadministration of Tan IIA may attenuate sevoflurane-induced neurotoxicity, suggesting that Tan IIA is a new and promising drug capable of counteracting the effects of cognitive dysfunction produced by general anesthetics...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28248319/safety-dosing-and-pharmaceutical-quality-for-studies-that-evaluate-medicinal-products-including-biological-products-in-neonates
#7
Robert M Ward, Daniel Benjamin, Jeffrey S Barrett, Karel Allegaert, Ronald Portman, Jonathan M Davis, Mark A Turner
The study of medications among pediatric patients has increased worldwide since 1997 in response to new legislation and regulations, but these studies have not yet adequately addressed the therapeutic needs of neonates. Additionally, extant guidance developed by regulatory agencies worldwide does not fully address the specificities of neonatal drug development, especially among extremely premature newborns who currently survive. Consequently, an international consortium from Canada, Europe, Japan, and the United States was organized by the Critical Path Institute to address the content of guidance...
March 1, 2017: Pediatric Research
https://www.readbyqxmd.com/read/27986495/current-strategies-for-the-long-term-assessment-monitoring-and-management-of-cystic-fibrosis-patients-treated-with-cftr-modulator-therapy
#8
J Stuart Elborn, Jane Davies, Marcus A Mall, Patrick A Flume, Barry Plant
The content for this activity is based on the satellite symposium, "Current Strategies for the Long-term Assessment, Monitoring, and Management for Cystic Fibrosis Patients Treated with CFTR Modulator Therapy" that was presented at the 39th European Cystic Fibrosis Society Conference on June 10, 2016 (Online access: http://courses.elseviercme.com/ecfs2016e/619e). The emergence of novel targeted agents, that directly correct CFTR loss function alleles, has created new treatment opportunities for patients with cystic fibrosis with advanced disease...
December 13, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/27890390/world-association-of-sleep-medicine-wasm-2016-standards-for-recording-and-scoring-leg-movements-in-polysomnograms-developed-by-a-joint-task-force-from-the-international-and-the-european-restless-legs-syndrome-study-groups-irlssg-and-eurlssg
#9
R Ferri, S Fulda, R P Allen, M Zucconi, O Bruni, S Chokroverty, L Ferini-Strambi, B Frauscher, D Garcia-Borreguero, M Hirshkowitz, B Högl, Y Inoue, A Jahangir, M Manconi, C L Marcus, D L Picchietti, G Plazzi, J W Winkelman, R S Zak
This report presents the results of the work by a joint task force of the International and European Restless Legs Syndrome Study Groups and World Association of Sleep Medicine that revised and updated the current standards for recording and scoring leg movements (LM) in polysomnographic recordings (PSG). First, the background of the decisions made and the explanations of the new rules are reported and then specific standard rules are presented for recording, detecting, scoring and reporting LM activity in PSG...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27826610/identification-of-long-bone-fractures-in-radiology-reports-using-natural-language-processing-to-support-healthcare-quality-improvement
#10
Robert W Grundmeier, Aaron J Masino, T Charles Casper, Jonathan M Dean, Jamie Bell, Rene Enriquez, Sara Deakyne, James M Chamberlain, Elizabeth R Alpern
BACKGROUND: Important information to support healthcare quality improvement is often recorded in free text documents such as radiology reports. Natural language processing (NLP) methods may help extract this information, but these methods have rarely been applied outside the research laboratories where they were developed. OBJECTIVE: To implement and validate NLP tools to identify long bone fractures for pediatric emergency medicine quality improvement. METHODS: Using freely available statistical software packages, we implemented NLP methods to identify long bone fractures from radiology reports...
November 9, 2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27741957/where-teachers-are-few-documenting-available-faculty-in-five-tanzanian-medical-schools
#11
Charles A Mkony, Ephata E Kaaya, Alex J Goodell, Sarah B Macfarlane
BACKGROUND: Faced with one of the lowest physician-to-population ratios in the world, the Government of Tanzania is urging its medical schools to train more physicians. The annual number of medical students admitted across the country rose from 55 in the 1990s to 1,680 approved places for the 2015/16 academic year. These escalating numbers strain existing faculty. OBJECTIVE: To describe the availability of faculty in medical schools in Tanzania. DESIGN: We identified faculty lists published on the Internet by five Tanzanian medical schools for the 2011/12 academic year and analyzed the appointment status, rank, discipline, and qualifications of faculty members...
2016: Global Health Action
https://www.readbyqxmd.com/read/27646479/moving-toward-a-paradigm-shift-in-the-regulatory-requirements-for-pediatric-medicines
#12
REVIEW
William Wei Lim Chin, Angelika Joos
Over the past two decades, there has been growing concern over the lack of proper medication for children. This review attempts to evaluate the current progress of EU Pediatric Regulation made since 2007. The lack of properly evaluated pediatric medication has for long been a source of concern in the European Union. The drugs that were used in the past were often not properly evaluated, and dosage was arbitrarily calculated. Therefore, it was necessary to establish the Pediatric Regulation (EC no. 1901/2006) in the EU which would mandate research for pediatric drugs...
December 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27625713/blog-and-podcast-watch-pediatric-emergency-medicine
#13
Fareen Zaver, Michael Hansen, Evan Leibner, Andrew Little, Michelle Lin
INTRODUCTION: By critically appraising open access, educational blogs and podcasts in emergency medicine (EM) using an objective scoring instrument, this installment of the ALiEM (Academic Life in Emergency Medicine) Blog and Podcast Watch series curated and scored relevant posts in the specific areas of pediatric EM. METHODS: The Approved Instructional Resources - Professional (AIR-Pro) series is a continuously building curriculum covering a new subject area every two months...
September 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27490462/impact-factors-and-prediction-of-popular-topics-in-a-journal
#14
M B Nielsen, K Seitz
The impact factor (IF) for 2015 was recently released and this could be the time to once again reflect on its use as a metric of a journal. Problems and concerns regarding the IF have been addressed extensively elsewhere 1 2. The principle of the IF for a given year is that it represents the average number of citations of articles published in the journal in the two previous years.While authors frequently cite the IF as a determining factor for submission, the IF does not predict how many times individual articles will be cited...
August 2016: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/27477090/recommendations-for-pharmacological-clinical-trials-in-children-with-irritable-bowel-syndrome-the-rome-foundation-pediatric-subcommittee-on-clinical-trials
#15
M Saps, M A L van Tilburg, J V Lavigne, A Miranda, M A Benninga, J A Taminiau, C Di Lorenzo
BACKGROUND: There is little published evidence of efficacy for the most commonly used treatments. Thus, there is an urgent need to conduct clinical trials on existing and novel therapies. PURPOSE: In order to address these issues the Rome Foundation and members of the Pediatric Committee of the European Medicines Agency formed a subcommittee on clinical trials to develop guidelines for the design of clinical trials in children with irritable bowel syndrome (IBS)...
July 31, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27464676/updated-clinical-guidelines-for-diagnosing-fetal-alcohol-spectrum-disorders
#16
H Eugene Hoyme, Wendy O Kalberg, Amy J Elliott, Jason Blankenship, David Buckley, Anna-Susan Marais, Melanie A Manning, Luther K Robinson, Margaret P Adam, Omar Abdul-Rahman, Tamison Jewett, Claire D Coles, Christina Chambers, Kenneth L Jones, Colleen M Adnams, Prachi E Shah, Edward P Riley, Michael E Charness, Kenneth R Warren, Philip A May
The adverse effects of prenatal alcohol exposure constitute a continuum of disabilities (fetal alcohol spectrum disorders [FASD]). In 1996, the Institute of Medicine established diagnostic categories delineating the spectrum but not specifying clinical criteria by which diagnoses could be assigned. In 2005, the authors published practical guidelines operationalizing the Institute of Medicine categories, allowing for standardization of FASD diagnoses in clinical settings. The purpose of the current report is to present updated diagnostic guidelines based on a thorough review of the literature and the authors' combined expertise based on the evaluation of >10 000 children for potential FASD in clinical settings and in epidemiologic studies in conjunction with National Institute on Alcohol Abuse and Alcoholism-funded studies, the Collaborative Initiative on Fetal Alcohol Spectrum Disorders, and the Collaboration on FASD Prevalence...
August 2016: Pediatrics
https://www.readbyqxmd.com/read/27438402/lumbar-spinous-process-fixation-and-fusion-a-systematic-review-and-critical-analysis-of-an-emerging-spinal-technology
#17
Alejandro J Lopez, Justin K Scheer, Nader S Dahdaleh, Alpesh A Patel, Zachary A Smith
STUDY DESIGN: A systematic review. OBJECTIVE: The available literature on interspinous rigid fixation/fusion devices (IFD) was systematically reviewed to explore the devices' efficacy and complication profile. SUMMARY OF BACKGROUND DATA: The clinical application of new spinal technologies may proceed without well-established evidence, as is the case with IFDs. IFDs are plate-like devices that are attached to the lateral aspects of 2 adjacent spinous processes to promote rigidity at that segment...
July 19, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27395403/aripiprazole-and-acute-extrapyramidal-symptoms-in-children-and-adolescents-a-meta-analysis
#18
REVIEW
Chiara Bernagie, Marina Danckaerts, Martien Wampers, Marc De Hert
BACKGROUND: Both the US FDA and the European Medicines Agency (EMA) have approved aripiprazole for use in adolescents for specific indications. Given the assumed favorable side-effect profile of aripiprazole, its use in children and adolescents has increased for both official and off-label indications (anxiety disorders, eating disorders, personality disorders). However, several cases of children and adolescents with new-onset extrapyramidal symptoms (EPS) after commencing treatment with aripiprazole have been reported, and a more systematic appraisal of this possible risk is lacking...
September 2016: CNS Drugs
https://www.readbyqxmd.com/read/27307737/update-on-the-role-of-eslicarbazepine-acetate-in-the-treatment-of-partial-onset-epilepsy
#19
REVIEW
Renato Tambucci, Claudia Basti, Maria Maresca, Giangennaro Coppola, Alberto Verrotti
Eslicarbazepine acetate (ESL) is a once daily new third generation antiepileptic drug that shares the basic chemical structure of carbamazepine and oxcarbazepine - a dibenzazepine nucleus with the 5-carboxamide substituent, but is structurally different at the 10,11-position. ESL is a pro-drug metabolized to its major active metabolite eslicarbazepine. Despite the fact that the exact mechanism of action has not been fully elucidated, it is thought to involve inhibition of voltage-gated sodium channels (VGSC)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27058819/sex-and-growth-effect-on-pediatric-hip-injuries-presenting-to-sports-medicine-clinic
#20
Andrea Stracciolini, Yi-Meng Yen, Pierre A d'Hemecourt, Cara L Lewis, Dai Sugimoto
UNLABELLED: To compare sports-related hip injuries on the basis of sex and age in a cohort of young athletes. A 5% random probability sample of all new patients' charts over a 10-year time period was selected for investigation. The most common hip injury diagnoses, sport at time of injury, mechanism (acute/traumatic vs. overuse), and types (bony vs. soft tissue) were compared by sex and age (preadolescent vs. adolescent). Descriptive and χ-analyses were carried out. The interaction of sex and age with respect to hip injury over time was examined by two-way (sex, age) analysis of variance...
July 2016: Journal of Pediatric Orthopedics. Part B
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