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photodynamic bladder cancer

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https://www.readbyqxmd.com/read/29110046/-supplementary-optical-techniques-for-the-detection-of-nonmuscle-invasive-bladder-cancer
#1
REVIEW
S Aeishen, Y Dawood, S Papadoukakis, M Horstmann
White light cystoscopy (WL) is the gold standard for the detection of bladder cancer. It can be performed using a rigid or flexible urethrocystoscope. With the more recent introduction of high definition (HD) techniques, WL cystoscopy has been decisively improved. Supplementary optical techniques are also used to improve the detection of bladder cancer. Among these are photodynamic diagnosis (PDD), narrow-band imaging (NBI), S‑technologies of IMAGE1 S, optical coherence tomography (OCT), confocal laser endomicroscopy (CLE), and Raman spectroscopy...
November 6, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29045251/novel-endoscopic-visualization-techniques-for-bladder-cancer-detection-a-review-of-the-contemporary-literature
#2
Andrea Mari, Mohammad Abufaraj, Killian M Gust, Shahrokh F Shariat
PURPOSE OF REVIEW: To describe the principles of photodynamic diagnosis (PDD), narrow-band imaging (NBI) and Storz Professional Image Enhancement System (SPIES) techniques for the endoscopic management of nonmuscle-invasive bladder cancer (BCa) and to report their impact on clinical practice. RECENT FINDINGS: PDD is associated with an increased sensitivity for detecting BCa specifically carcinoma in situ (CIS). Moreover, PDD has been shown to lower recurrence rate in comparison with white-light cystoscopy...
October 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29031069/synthesis-and-biological-evaluation-of-a-platinum-ii-c-rgdyk-conjugate-for-integrin-targeted-photodynamic-therapy
#3
T Chatzisideri, S Thysiadis, S Katsamakas, P Dalezis, I Sigala, T Lazarides, E Nikolakaki, D Trafalis, O A Gederaas, M Lindgren, V Sarli
A cancer-targeting conjugate 4 of a cyclometalated [N,C,N-Pt(II)] complex bearing a NˆCˆN 1,3-di(2-pyridyl)-benzene with c(RGDyK) peptide as guiding molecule was designed and synthesized for real-time drug delivery monitoring in cancer cells and photodynamic therapy (PDT). This conjugate demonstrates a mild cytostatic effect to six cancer cell lines expressing integrins at different extent, while possessing promising features for PDT. Conjugate 4 demonstrated rapid cell uptake by receptor-mediated endocytosis and efficient generation of (1)O2 upon irradiation...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28972608/photochemical-internalization-in-bladder-cancer-development-of-an-orthotopic-in-vivo-model
#4
Odrun A Gederaas, Anders Johnsson, Kristian Berg, Rojlina Manandhar, Chetana Shrestha, Daniel Skåre, Ingvild Kinn Ekroll, Anders Høgset, Astrid Hjelde
The possibility of using photochemical internalization (PCI) to enhance the effects of the cytotoxic drug bleomycin is investigated, together with photophysical determination and outlines of a possible treatment for intravesical therapy of bladder cancer. In vitro experiments indicated that the employment of PCI technology using the novel photosensitizer TPCS2a® can enhance the cytotoxic effect of bleomycin in bladder cancer cells. Furthermore, experiments in an orthotopic in vivo bladder cancer model show an effective reduction in both the necrotic area and the bladder weight after TPCS2a based photodynamic therapy (PDT)...
November 8, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28803385/-real-life-experience-recurrence-rate-at-3%C3%A2-years-with-hexvix-%C3%A2-photodynamic-diagnosis-assisted-turbt-compared-with-good-quality-white-light-turbt-in-new-nmibc-a-prospective-controlled-study
#5
Kevin M Gallagher, Kayleigh Gray, Claire H Anderson, Hannah Lee, Sarah Stewart, Roland Donat, Paramananthan Mariappan
PURPOSE: To compare the recurrence rate at 3 years (RR-3y) for non-muscle invasive bladder cancer (NMIBC) between good quality (GQ) PDD-TURBT and GQWL-TURBT where PDD is used in routine practice for all new tumours. METHODS: All new, consecutive, NMIBC that received "good quality" criteria first TURBT across a university hospital service were prospectively recruited to this study over a 4-year period. Data were prospectively collected on all WL-TURBTs performed in 2007/8 and compared with PDD-TURBT from 2009/10...
August 12, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28726046/spectrophotometric-photodynamic-detection-involving-extracorporeal-treatment-with-hexaminolevulinate-for-bladder-cancer-cells-in-voided-urine
#6
Yasushi Nakai, Toshiyuki Ozawa, Fumiko Mizuno, Sayuri Onishi, Takuya Owari, Syunta Hori, Yosuke Morizawa, Yosihiro Tatsumi, Makito Miyake, Nobumichi Tanaka, Daisuke Tsuruta, Kiyohide Fujimoto
PURPOSE: To evaluate the feasibility of hexaminolevulinate (HAL) for the photodynamic detection of cancer cells in voided urine. METHODS: This study included 50 patients with bladder cancer that was confirmed histologically after transurethral resection (bladder cancer group) and 50 outpatients without a history of urothelial carcinoma or cancer-related findings (no malignancy group). One third of the voided urine samples were incubated with aminolevulinic acid (ALA-treated samples), one third were incubated with HAL (HAL-treated samples), and the remaining samples were incubated without treatment (untreated samples)...
November 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28609792/-systematic-review-on-conservative-treatment-options-in-non-muscle-invasive-bladder-cancer-patients-refractory-to-bacillus-calmette-gu%C3%A3-rin-instillation-therapy
#7
Thomas Martini, Felix Wezel, Niklas Löbig, Michael J Mitterberger, Daniela Colleselli
Background Adjuvant Bacillus Calmette-Guérin (BCG) intravesical instillation is the recommended standard treatment in patients with high-risk non-muscle-invasive bladder cancer (NMIBC). However, a significant proportion of patients fail treatment, and radical cystectomy (RC) is the subsequent gold standard. On the other hand, there is an unmet need for conservative alternatives for patients who are unfit or unwilling to undergo surgery. This study aimed to identify conservative treatment options in NMIBC patients after BCG failure...
August 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28537820/photodynamic-diagnosis-and-narrow-band-imaging-in-the-management-of-bladder-cancer-a-review
#8
Piotr Kutwin, Tomasz Konecki, Marcin Cichocki, Piotr Falkowski, Zbigniew Jabłonowski
BACKGROUND: Bladder cancer is the most common malignancy of the urinary tract. Its proper diagnosis and efficient treatment is still considered a challenge in urology today. White light cystoscopy is a gold standard for the diagnosis, follow-up, and endoscopic treatment of bladder cancer. To improve the efficacy of bladder cancer management, photodynamic diagnosis and narrow-band imaging have been introduced to the urological armamentarium. OBJECTIVE AND METHODS: The article presents the current state of knowledge of technical solutions that are intended to improve the diagnosis and management of bladder cancer...
September 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28472723/activity-of-phosphatase-sensitive-5-aminolevulinic-acid-prodrugs-in-cancer-cell-lines
#9
Viktorija Herceg, Norbert Lange, Eric Allémann, Andrej Babič
5-aminolevulinc acid (5-ALA)-based photodynamic therapy (PDT) and photodiagnosis (PD) present many advantages over treatments with conventional photosensitizers (PS). It offers great tumor specificity, reduced photosensitivity reactions caused by PS accumulation in non-targeted tissues and also inherent PS metabolism into endogenous non-fluorescent heme. However, chemical instability, low bioavailability and poor pharmacokinetic profile limit systemic efficacy of 5-ALA. Here, we present a comprehensive in vitro evaluation of novel phosphatase-sensitive prodrugs of 5-ALA...
June 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28416355/expression-of-coproporphyrinogen-oxidase-is-associated-with-detection-of-upper-gastrointestinal-carcinomas-by-5-aminolevulinic-acid-mediated-photodynamic-diagnosis
#10
Kumi Ogihara, Hajime Isomoto, Hiroki Kurumi, Tsutomu Kanda, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Kayoko Matsushima, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao
BACKGROUND: 5-Aminolevulinic acid is a precursor of photosensitizing protoporphyrin IX and has been applied for photodynamic diagnosis of brain and bladder tumors with few side effects. Although most upper gastrointestinal tumors can be detected during photodynamic diagnosis, some tumors containing signet-ring cells cannot be visualized. Here, we aimed to assess whether proteins involved in the absorbance, activation, and turnover of protoporphyrin IX altered the fluorescence signal in gastric cancer...
September 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28326794/urothelial-tumors-and-dual-band-imaging-a-new-concept-in-confocal-laser-endomicroscopy
#11
Arnaud Marien, Aurélien Rock, Khaled El Maadarani, Catherine Francois, Pierre Gosset, Brigitte Mauroy, Jean-Louis Bonnal
OBJECTIVES: Confocal laser endomicroscopy (CLE) uses a low-energy laser light source to obtain microscopic histology images of bladder tissue exposed to a fluorescent dye. To evaluate the feasibility of using CLE with two fluorophores: fluorescein (FLUO) and hexylaminolevulinate (HAL) to determine histologic and cytologic bladder cancer criteria. METHODS: Patients eligible for HAL-photodynamic diagnosis-assisted transurethral resection of bladder tumor were included...
May 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28324275/the-impact-of-blue-light-cystoscopy-on-the-diagnosis-and-treatment-of-bladder-cancer
#12
REVIEW
Eugene J Pietzak
Photodynamic diagnostic technique with blue light cystoscopy (BLC) takes advantage of the preferential uptake and accumulation of protoporphyrins in neoplastic tissue which emit a red fluorescence when illuminated with blue light (360-450 nm wavelengths). This allows enhanced visualization of small papillary tumors and flat carcinoma in situ lesions that might have been missed on white light cystoscopy (WLC). There is compelling evidence that the ability of BLC to detect these additional tumors translates into improved recurrence rates compared to WLC...
May 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28283914/transurethral-resection-of-bladder-tumors-improving-quality-through-new-techniques-and-technologies
#13
REVIEW
Daniel Zainfeld, Siamak Daneshmand
PURPOSE OF REVIEW: Cystoscopy with transurethral resection of bladder tumors (TURBT) is essential in the diagnosis of bladder cancer as well as the management of non-muscle-invasive disease yet remains a comparatively imprecise procedure secondary to variability among patients, tumors, and surgeons alike. We will review evolving technologies and techniques used to enhance safety and efficacy of TURBT performance and education in the management of bladder cancer. RECENT FINDINGS: Though a generally safe procedure, efficacy of TURBT in terms of complete tumor excision, appropriate pathologic diagnosis, and absence of complications can vary significantly with direct impact on patient outcomes...
May 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28282341/new-developments-in-the-management-of-nonmuscle-invasive-bladder-cancer
#14
Mark D Tyson, Daniel Lee, Peter Clark
PURPOSE OF REVIEW: In this review, we summarize the core principles in the management of nonmuscle invasive bladder cancer (NMIBC) with an emphasis on new developments that have emerged over the last year. RECENT FINDINGS: NMIBC has a propensity to recur and progress. Risk stratification has facilitated appropriate patient selection for treatment but improved tools, including biomarkers, are still needed. Enhanced cystoscopy with photodynamic imaging and narrow band imaging show promise for diagnosis, risk stratification, and disease monitoring and has been formally recommended this year by the American Urological Association...
March 9, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28279796/tetrahydroporphyrin-tetratosylat-thpts-a-near-infrared-photosensitizer-for-targeted-and-efficient-photodynamic-therapy-pdt-of-human-bladder-carcinoma-an-in-vitro-study
#15
Mandy Berndt-Paetz, Annett Weimann, Nadine Sieger, Stanislaw Schastak, Yasser M Riyad, Jan Griebel, Vinodh K A Arthanareeswaran, Jens-Uwe Stolzenburg, Jochen Neuhaus
BACKGROUND: Efficacy of PDT in muscle-invasive bladder cancer is hampered by low tissue penetration of most photosensitizers by short excitation wavelength. THPTS is excitable at near-infrared (760nm) allowing tissue penetration up to 15mm. We examined the cellular effects of THPTS-PDT in human bladder cancer cells. MATERIAL AND METHODS: We used four human transitional carcinoma cell lines, epithelial bladder progenitors (HBLAK) and bladder smooth muscle cells (HBSMC)...
March 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28247741/-a-systematic-review-and-meta-analysis-to-assess-the-recurrence-free-survival-in-non-muscle-invasive-bladder-cancer-after-transurethral-resection-guided-by-5-aminolevulinic-acid-induced-photodynamic-diagnosis-compared-with-white-light-transurethral-resect
#16
REVIEW
A I Rolevich, A A Evmenenko
INTRODUCTION: We conducted a meta-analysis assessing the effect of photodynamic diagnosis (PDD) -guided transurethral resection of the bladder tumor (TURB) on the recurrence-free survival in patients with non-muscle invasive bladder cancer within prospective randomised trials that used 5-aminolevulinic acid as a photosensitizer. MATHERIAL AND METHODS: Medical literature search was performed up to February 2016. Recurrence hazard ratios (HRs) and its 95% confidence intervals (CI) were calculated for each selected study with direct and indirect methods and the pooled estimates were obtained with random-effects model...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28192305/an-optical-method-for-reducing-green-fluorescence-from-urine-during-fluorescence-guided-cystoscopy
#17
Lars R Lindvold, Gregers G Hermann
Photodynamic diagnosis (PDD) of bladder tumour tissue significantly improves endoscopic diagnosis and treatment of bladder cancer in rigid cystoscopes in the operating theatre and thus reduces tumour recurrence. PDD comprises the use of blue light, which unfortunately excites green fluorescence from urine. As this green fluorescence confounds the desired red fluorescence of the PDD, methods for avoiding this situation particularly in cystoscopy using flexible cystoscopes are desirable. In this paper we demonstrate how a tailor made high power LED light source at 525 nm can be used for fluorescence assisted tumour detection using both a flexible and rigid cystoscope used in the outpatient department (OPD) and operating room (OR) respectively...
November 14, 2016: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28191719/5-aminolevulinic-acid-mediated-photodynamic-therapy-for-bladder-cancer
#18
REVIEW
Keiji Inoue
Photodynamic therapy using 5-aminolevulinic acid is a treatment method in which the fluorescent substance of protoporphyrin IX excessively accumulated specifically in cancer cells is excited by visible red or green light irradiation, and reactive oxygen is produced and injures cancer cells. Photodynamic therapy using 5-aminolevulinic acid less markedly influences the surrounding normal cells and tissue as a result of no accumulation of protoporphyrin IX, being a low-invasive, less harmful treatment localized to cancer...
February 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28101348/evans-blue-mediated-white-light-detection-of-non-muscle-invasive-bladder-cancer-a-preclinical-feasibility-and-safety-study-using-a-rat-bladder-urothelial-cell-carcinoma-model
#19
Sanne Elsen, Evelyne Lerut, Frank Van Der Aa, Ben Van Cleynenbreugel, Hendrik Van Poppel, Peter De Witte
Photodynamic diagnosis (PDD) improves the detection of non-muscle-invasive bladder cancer (NMIBC). However, white-light (WL) cystoscopy remains the technique routinely used in urological clinics. A more cost-effective but equally performant alternative to PDD may encompass the use of an intense tumoritropic dye in combination with WL cystoscopy. Using a preclinical setting, we investigated the practical aspects of the use of Evans blue (EB) dye for the possible future detection of NMIBC using WL cystoscopy...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27973635/%C3%AE-v%C3%AE-3-isoform-specific-erbium-complexes-highly-specific-for-bladder-cancer-imaging-and-photodynamic-therapy
#20
Yan Zhou, Chi-Fai Chan, Daniel W J Kwong, Ga-Lai Law, Steven Cobb, Wai-Kwok Wong, Ka-Leung Wong
We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.
January 3, 2017: Chemical Communications: Chem Comm
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