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photodynamic bladder cancer

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https://www.readbyqxmd.com/read/28609792/-systematic-review-on-conservative-treatment-options-in-non-muscle-invasive-bladder-cancer-patients-refractory-to-bacillus-calmette-gu%C3%A3-rin-instillation-therapy
#1
Thomas Martini, Felix Wezel, Niklas Löbig, Michael J Mitterberger, Daniela Colleselli
Background Adjuvant Bacillus Calmette-Guérin (BCG) intravesical instillation is the recommended standard treatment in patients with high-risk non-muscle-invasive bladder cancer (NMIBC). However, a significant proportion of patients fail treatment, and radical cystectomy (RC) is the subsequent gold standard. On the other hand, there is an unmet need for conservative alternatives for patients who are unfit or unwilling to undergo surgery. This study aimed to identify conservative treatment options in NMIBC patients after BCG failure...
June 13, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28537820/photodynamic-diagnosis-and-narrow-band-imaging-in-the-management-of-bladder-cancer-a-review
#2
Piotr Kutwin, Tomasz Konecki, Marcin Cichocki, Piotr Falkowski, Zbigniew Jabłonowski
BACKGROUND: Bladder cancer is the most common malignancy of the urinary tract. Its proper diagnosis and efficient treatment is still considered a challenge in Urology today. White Light Cystoscopy is a gold standard for the diagnosis, follow-up, and endoscopic treatment of bladder cancer. To improve the efficacy of bladder cancer management, photodynamic diagnosis and narrow-band imaging have been introduced to the urological armamentarium. OBJECTIVE AND METHODS: The article presents the current state of knowledge of technical solutions that are intended to improve the diagnosis and management of bladder cancer...
May 22, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28472723/activity-of-phosphatase-sensitive-5-aminolevulinic-acid-prodrugs-in-cancer-cell-lines
#3
Viktorija Herceg, Norbert Lange, Eric Allémann, Andrej Babič
5-aminolevulinc acid (5-ALA)-based photodynamic therapy (PDT) and photodiagnosis (PD) present many advantages over treatments with conventional photosensitizers (PS). It offers great tumor specificity, reduced photosensitivity reactions caused by PS accumulation in non-targeted tissues and also inherent PS metabolism into endogenous non-fluorescent heme. However, chemical instability, low bioavailability and poor pharmacokinetic profile limit systemic efficacy of 5-ALA. Here, we present a comprehensive in vitro evaluation of novel phosphatase-sensitive prodrugs of 5-ALA...
June 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28416355/expression-of-coproporphyrinogen-oxidase-is-associated-with-detection-of-upper-gastrointestinal-carcinomas-by-5-aminolevulinic-acid-mediated-photodynamic-diagnosis
#4
Kumi Ogihara, Hajime Isomoto, Hiroki Kurumi, Tsutomu Kanda, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Kayoko Matsushima, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao
BACKGROUND: 5-Aminolevulinic acid is a precursor of photosensitizing protoporphyrin IX and has been applied for photodynamic diagnosis of brain and bladder tumors with few side effects. Although most upper gastrointestinal tumors can be detected during photodynamic diagnosis, some tumors containing signet-ring cells cannot be visualized. Here, we aimed to assess whether proteins involved in the absorbance, activation, and turnover of protoporphyrin IX altered the fluorescence signal in gastric cancer...
April 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28326794/urothelial-tumors-and-dual-band-imaging-a-new-concept-in-confocal-laser-endomicroscopy
#5
Arnaud Marien, Aurélien Rock, Khaled El Maadarani, Catherine Francois, Pierre Gosset, Brigitte Mauroy, Jean-Louis Bonnal
OBJECTIVES: Confocal laser endomicroscopy (CLE) uses a low-energy laser light source to obtain microscopic histology images of bladder tissue exposed to a fluorescent dye. To evaluate the feasibility of using CLE with two fluorophores: fluorescein (FLUO) and hexylaminolevulinate (HAL) to determine histologic and cytologic bladder cancer criteria. METHODS: Patients eligible for HAL-photodynamic diagnosis-assisted transurethral resection of bladder tumor were included...
May 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28324275/the-impact-of-blue-light-cystoscopy-on-the-diagnosis-and-treatment-of-bladder-cancer
#6
REVIEW
Eugene J Pietzak
Photodynamic diagnostic technique with blue light cystoscopy (BLC) takes advantage of the preferential uptake and accumulation of protoporphyrins in neoplastic tissue which emit a red fluorescence when illuminated with blue light (360-450 nm wavelengths). This allows enhanced visualization of small papillary tumors and flat carcinoma in situ lesions that might have been missed on white light cystoscopy (WLC). There is compelling evidence that the ability of BLC to detect these additional tumors translates into improved recurrence rates compared to WLC...
May 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28283914/transurethral-resection-of-bladder-tumors-improving-quality-through-new-techniques-and-technologies
#7
REVIEW
Daniel Zainfeld, Siamak Daneshmand
PURPOSE OF REVIEW: Cystoscopy with transurethral resection of bladder tumors (TURBT) is essential in the diagnosis of bladder cancer as well as the management of non-muscle-invasive disease yet remains a comparatively imprecise procedure secondary to variability among patients, tumors, and surgeons alike. We will review evolving technologies and techniques used to enhance safety and efficacy of TURBT performance and education in the management of bladder cancer. RECENT FINDINGS: Though a generally safe procedure, efficacy of TURBT in terms of complete tumor excision, appropriate pathologic diagnosis, and absence of complications can vary significantly with direct impact on patient outcomes...
May 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28282341/new-developments-in-the-management-of-nonmuscle-invasive-bladder-cancer
#8
Mark D Tyson, Daniel Lee, Peter Clark
PURPOSE OF REVIEW: In this review, we summarize the core principles in the management of nonmuscle invasive bladder cancer (NMIBC) with an emphasis on new developments that have emerged over the last year. RECENT FINDINGS: NMIBC has a propensity to recur and progress. Risk stratification has facilitated appropriate patient selection for treatment but improved tools, including biomarkers, are still needed. Enhanced cystoscopy with photodynamic imaging and narrow band imaging show promise for diagnosis, risk stratification, and disease monitoring and has been formally recommended this year by the American Urological Association...
March 9, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28279796/tetrahydroporphyrin-tetratosylat-thpts-a-near-infrared-photosensitizer-for-targeted-and-efficient-photodynamic-therapy-pdt-of-human-bladder-carcinoma-an-in-vitro-study
#9
Mandy Berndt-Paetz, Annett Weimann, Nadine Sieger, Stanislaw Schastak, Yasser M Riyad, Jan Griebel, Vinodh K A Arthanareeswaran, Jens-Uwe Stolzenburg, Jochen Neuhaus
BACKGROUND: Efficacy of PDT in muscle-invasive bladder cancer is hampered by low tissue penetration of most photosensitizers by short excitation wavelength. THPTS is excitable at near-infrared (760nm) allowing tissue penetration up to 15mm. We examined the cellular effects of THPTS-PDT in human bladder cancer cells. MATERIAL AND METHODS: We used four human transitional carcinoma cell lines, epithelial bladder progenitors (HBLAK) and bladder smooth muscle cells (HBSMC)...
March 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28247741/-a-systematic-review-and-meta-analysis-to-assess-the-recurrence-free-survival-in-non-muscle-invasive-bladder-cancer-after-transurethral-resection-guided-by-5-aminolevulinic-acid-induced-photodynamic-diagnosis-compared-with-white-light-transurethral-resect
#10
A I Rolevich, A A Evmenenko
INTRODUCTION: We conducted a meta-analysis assessing the effect of photodynamic diagnosis (PDD) -guided transurethral resection of the bladder tumor (TURB) on the recurrence-free survival in patients with non-muscle invasive bladder cancer within prospective randomised trials that used 5-aminolevulinic acid as a photosensitizer. MATHERIAL AND METHODS: Medical literature search was performed up to February 2016. Recurrence hazard ratios (HRs) and its 95% confidence intervals (CI) were calculated for each selected study with direct and indirect methods and the pooled estimates were obtained with random-effects model...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28192305/an-optical-method-for-reducing-green-fluorescence-from-urine-during-fluorescence-guided-cystoscopy
#11
Lars R Lindvold, Gregers G Hermann
Photodynamic diagnosis (PDD) of bladder tumour tissue significantly improves endoscopic diagnosis and treatment of bladder cancer in rigid cystoscopes in the operating theatre and thus reduces tumour recurrence. PDD comprises the use of blue light, which unfortunately excites green fluorescence from urine. As this green fluorescence confounds the desired red fluorescence of the PDD, methods for avoiding this situation particularly in cystoscopy using flexible cystoscopes are desirable. In this paper we demonstrate how a tailor made high power LED light source at 525 nm can be used for fluorescence assisted tumour detection using both a flexible and rigid cystoscope used in the outpatient department (OPD) and operating room (OR) respectively...
November 14, 2016: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28191719/5-aminolevulinic-acid-mediated-photodynamic-therapy-for-bladder-cancer
#12
REVIEW
Keiji Inoue
Photodynamic therapy using 5-aminolevulinic acid is a treatment method in which the fluorescent substance of protoporphyrin IX excessively accumulated specifically in cancer cells is excited by visible red or green light irradiation, and reactive oxygen is produced and injures cancer cells. Photodynamic therapy using 5-aminolevulinic acid less markedly influences the surrounding normal cells and tissue as a result of no accumulation of protoporphyrin IX, being a low-invasive, less harmful treatment localized to cancer...
February 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28101348/evans-blue-mediated-white-light-detection-of-non-muscle-invasive-bladder-cancer-a-preclinical-feasibility-and-safety-study-using-a-rat-bladder-urothelial-cell-carcinoma-model
#13
Sanne Elsen, Evelyne Lerut, Frank Van Der Aa, Ben Van Cleynenbreugel, Hendrik Van Poppel, Peter De Witte
Photodynamic diagnosis (PDD) improves the detection of non-muscle-invasive bladder cancer (NMIBC). However, white-light (WL) cystoscopy remains the technique routinely used in urological clinics. A more cost-effective but equally performant alternative to PDD may encompass the use of an intense tumoritropic dye in combination with WL cystoscopy. Using a preclinical setting, we investigated the practical aspects of the use of Evans blue (EB) dye for the possible future detection of NMIBC using WL cystoscopy...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27973635/%C3%AE-v%C3%AE-3-isoform-specific-erbium-complexes-highly-specific-for-bladder-cancer-imaging-and-photodynamic-therapy
#14
Yan Zhou, Chi-Fai Chan, Daniel W J Kwong, Ga-Lai Law, Steven Cobb, Wai-Kwok Wong, Ka-Leung Wong
We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.
January 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27960233/iatrogenic-changes-in-the-urinary-tract
#15
REVIEW
Antonio Lopez-Beltran, Gladell P Paner, Rodolfo Montironi, Maria R Raspollini, Liang Cheng
A handful of therapeutic procedures are used to treat malignancies of the urinary tract, most frequently intravesical immunotherapy or chemotherapy, but also neoadjuvant systemic chemotherapy. These treatment modalities produce morphological changes in the urothelium that can be mistaken for carcinoma; in particular, these therapies frequently mimic urothelial carcinoma in situ (CIS) urothelial dysplasia or true invasive neoplasia. Drugs such as mitomycin C used after transurethral resection of bladder tumour to reduce recurrences, bacillus Calmette-Guérin (BCG) intravesical immunotherapy to treat high-risk non-muscle-invasive bladder cancer and urothelial CIS and platin-based systemic chemotherapy to improve postcystectomy disease-specific survival are examples of therapy-related atypia seen in the urinary tract...
January 2017: Histopathology
https://www.readbyqxmd.com/read/27941379/can-we-improve-transurethral-resection-of-the-bladder-tumour-for-nonmuscle-invasive-bladder-cancer
#16
Esmee Iml Liem, Theo M de Reijke
PURPOSE OF REVIEW: The recurrence rate in patients with nonmuscle invasive bladder cancer is high, and the quality of transurethral resection of the bladder (TURB) tumour influences recurrence risk. We review new methods that aim to improve the effectiveness of TURB, and highlight studies of the past year. RECENT FINDINGS: Several approaches have been explored: bipolar resection is well tolerated and efficient; however, surgical outcomes are not clearly superior to monopolar resection; en-bloc resection seems feasible and well tolerated, and has the potential to improve the quality of tissue for histopathology; enhancement techniques such as photodynamic diagnosis, narrow band imaging, and Image1 S improve tumour detection, whereas photodynamic diagnosis reduces recurrence rates; high-resolution imaging modality such as confocal laser endomicroscopy may provide histopathologic information...
March 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/27776475/multiple-means-by-which-nitric-oxide-can-antagonize-photodynamic-therapy
#17
REVIEW
Albert W Girotti, Jonathan M Fahey, Witold Korytowski
Photodynamic therapy (PDT) is a unique site-specific treatment for eradicating a variety of solid tumors, including prostate, lung, bladder, and brain tumors. PDT is a three-component modality involving (i) administration of a photosensitizing agent (PS), (ii) PS photoexcitation by visible or near-infrared light, and (iii) molecular oxygen. Upon photoexcitation, PS gives rise to tumor-damaging reactive oxygen species, most prominently singlet oxygen (1O2). Previous studies revealed that endogenous nitric oxide (NO) in various mouse tumor models significantly reduced PDT effectiveness...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27750007/mitochondria-targeted-photodynamic-therapy-with-a-galactodendritic-chlorin-to-enhance-cell-death-in-resistant-bladder-cancer-cells
#18
Patrícia M R Pereira, Sandrina Silva, Mafalda Bispo, Mónica Zuzarte, Célia Gomes, Henrique Girão, José A S Cavaleiro, Carlos A F Ribeiro, João P C Tomé, Rosa Fernandes
Here, we report the rational design of a new third-generation photosensitizer (PS), a chlorin conjugated with galactodendritic units, ChlGal8, to improve the effectiveness of bladder cancer treatment. ChlGal8 shows better photochemical and photophysical properties than a recently reported homologous porphyrin, PorGal8. In addition to inheriting excellent photostability, the ability to generate singlet oxygen, and the ability to interact with the proteins galectin-1 and human serum albumin (HSA), ChlGal8 exhibits high absorption in the red region of the electromagnetic spectrum...
November 16, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27718388/the-role-of-galectin-1-in-in%C3%A2-vitro-and-in%C3%A2-vivo-photodynamic-therapy-with-a-galactodendritic-porphyrin
#19
Patrícia M R Pereira, Sandrina Silva, José S Ramalho, Célia M Gomes, Henrique Girão, José A S Cavaleiro, Carlos A F Ribeiro, João P C Tomé, Rosa Fernandes
Conventional photodynamic agents used in clinic are porphyrin-based photosensitizers. However, they have low tumour selectivity, which may induce unwanted side-effects and damage to healthy tissues. In this study, we used a porphyrin with dendritic units of galactose (PorGal8) developed by us, which can target the galactose-binding protein, galectin-1, known to be overexpressed in many tumour tissues. In vitro and in vivo studies had been conducted for the validation of PorGal8 effectiveness. We showed a specific uptake of PorGal8 and induction of apoptotic cell death by generating oxidative stress and alterations in the cytoskeleton of bladder cancer cells overexpressing galectin-1...
October 5, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27671517/5-aminolevulinic-acid-in-intraoperative-photodynamic-therapy-of-bladder-cancer-results-of-multicenter-trial
#20
MULTICENTER STUDY
E V Filonenko, A D Kaprin, B Y A Alekseev, O I Apolikhin, E K Slovokhodov, V I Ivanova-Radkevich, A N Urlova
The results of multicenter prospective trial for efficacy of combined modality treatment: transurethral resection (TUR)+photodynamic therapy (PDT) with alasens for bladder cancer are represented in the article. Trials were organized by Research Institute of Organic Intermediates and Dyes and conducted according to clinical protocol approved by Ministry of Health of Russia, at the sites of leading Russian cancer clinical centers. The trial included 45 subjects with verified diagnosis of non-muscle-invasive bladder cancer...
December 2016: Photodiagnosis and Photodynamic Therapy
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