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athrophic rhinitis

Hu-Lin Jiang, In-Kyu Park, Na-Ri Shin, Sang-Gyun Kang, Han-Sang Yoo, Su-Il Kim, Sang-Bong Suh, Toshihiro Akaike, Chong-Su Cho
Chitosan microspheres (CMs) were prepared by an ionic gelation process with tripolyphosphate and characterized. Bordetella Bronchiseptica Dermonecrotoxin (BBD), a major virulence factor of a causative agent of atrophic rhinitis (AR), was loaded on to the CMs for nasal vaccination. BBD-loaded CMs were observed as aggregated shapes although unloaded CMs were observed as relatively spherical ones. The average particle size of the BBD-loaded CMs was 4.39 microm. The lower the molecular weight of chitosan and the higher the medium pH, the greater was the release of BBD from the BBD-loaded CMs in vitro due to weaker intermolecular interaction between chitosan and BBD...
November 2004: European Journal of Pharmaceutics and Biopharmaceutics
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