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Nicholas Castle, Doug Olson, Urvi Shah, Kevin Hansen
BACKGROUND: This study explores the relationship between recipients of an association-sponsored Quality Award Program and select measures of quality in U.S. nursing facilities, examined both cross-sectionally and over time. METHOD: Data used came from Quality Award Program recipients over 9 years (2003-2011) and a set of quality indicators from the Online Survey Certification and Reporting (OSCAR) database. These data were analyzed using a variety of multivariate regression techniques...
September 7, 2016: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
Daryl E Miller, Teresa E Roane, Jennifer A Salo, Heather C Hardin
BACKGROUND: Medication therapy management (MTM) programs were first introduced as a result of the 2003 Medicare Prescription Drug Improvement and Modernization Act. Since then, the Centers for Medicare & Medicaid Services (CMS) have established minimum requirements for health plans to follow in establishing patient eligibility for enrollment in these programs. The eligibility criteria are based on projected annual Part D medication costs, number of chronic disease states, and number of chronic Part D covered medications...
July 2016: Journal of Managed Care & Specialty Pharmacy
Dustin D French, Curtis E Margo, Robert R Campbell, Paul B Greenberg
Cataract is the most common surgically reversible cause of vision loss and the most common major surgical procedure performed in the United States. To understand how gender composition might affect differences in health services, we examined the surgeon gender-specific rates of routine cataract surgery performed in ambulatory surgical centers in Florida. Routine cataract surgeries were identified through the Florida Agency for Health Care Administration (AHCA) ambulatory surgery center dataset. The background of individual surgeons was determined by linking license numbers in the dataset to physician profiles publicly available from AHCA...
March 2016: Journal of Medical Practice Management: MPM
Anna Ialynytchev, Alan M Sear, Arthur R Williams, Barbara Langland-Orban, Nanhua Zhang
PURPOSE: The objective of this study is to identify the demographic and payer factors that are associated with lumbar fusion surgery. METHODS: A case-control study was conducted utilizing a population of 38,092 patients from the 2010 Florida Agency for Health Care Administration (AHCA), USA hospital discharge data. The case population included 16,236 records with any of five ICD-9-CM principal procedure codes for initial lumbar fusion. The control group was comprised of 21,856 patients who were admitted for the same principal diagnoses as the cases, but who did not have initial fusion surgery...
May 6, 2016: European Spine Journal
Anna Ialynytchev, Alan M Sear, Arthur R Williams, Barbara Langland-Orban, Nanhua Zhang
STUDY DESIGN: A mixed-effects model was used to evaluate the effects specific surgical procedure by International Classification of Diseases, Ninth Revision, Clinical Modification, procedure code, patient age, sex, ethnic group, payers for the inpatient hospital stay, and number of additional diagnoses beyond the principal diagnosis that led to the procedure (as a proxy for severity of illness) on the charges for lumbar fusion surgery. OBJECTIVE: The present research examined the charges and the predictors of the charges for lumbar fusion surgery in Florida hospitals in 2010...
November 1, 2014: Spine
Hangshu Xin, Peiqiang Yu
In this experiment, brown- and yellow-seeded Brassica carinata were selected to use as a model to investigate whether there were any changes in lipid-related structure make-up (including CH3 and CH2 asymmetric and symmetric stretching bands ca. 3010-2765cm(-1), unsaturated lipid band ca. 3043-2987cm(-1) and carbonyl CO ester band ca. 1789-1701cm(-1)) of oilseed tissue during rumen in situ incubation using attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FT/IR). Correlations of lipid spectral characteristics with basic chemical profile and multivariate analyses for clarifying structural differences within lipid regions between two carinata seeds were also measured...
December 10, 2014: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
State Of Florida Agency For Health Care Administration State Center For Health Statistics
SUMMARY: Low-back injuries are among the most common and costly work-related injuries. Many studies show a wide variation in the diagnostic and therapeutic approaches to treat these injuries. To help standardize medical practice patterns and reduce the use of procedures with little or no proven benefit, the Agency for Health Care Administration (AHCA) developed and endorsed a scientifically sound medical practice guideline for the treatment of low-back injuries.This study investigates the potential of the guideline to reduce workers' compensation costs by reducing unnecessary diagnostic and therapeutic treatments to workers with low-back injuries...
January 1, 1998: Journal of Back and Musculoskeletal Rehabilitation
Katerina Theodoridou, Sally Vail, Peiqiang Yu
This study was conducted to characterize the protein molecular structure in endosperm tissues in newly developed black and yellow-type canola seeds by using synchrotron-based Fourier transform infrared microspectroscopy. The results showed that the yellow canola seeds contained relatively lower (P<0.05) percentage of β-sheet and amide I and amide II area compared to the black-type canola seed. This might be an indication that the protein value of the yellow canola seeds as food or feed is different from that of the black canola seeds...
2014: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Ahcène Boumendjel, Germain Sotoing Taïwe, Elisabeth Ngo Bum, Tanguy Chabrol, Chantal Beney, Valérie Sinniger, Romain Haudecoeur, Laurence Marcourt, Soura Challal, Emerson Ferreira Queiroz, Florence Souard, Marc Le Borgne, Thierry Lomberget, Antoine Depaulis, Catherine Lavaud, Richard Robins, Jean-Luc Wolfender, Bruno Bonaz, Michel De Waard
No abstract text is available yet for this article.
November 4, 2013: Angewandte Chemie
Frank Zongo, Christophe Ribuot, Ahcène Boumendjel, Innocent Guissou
Waltheria indica is used in traditional pharmacopeia in Burkina Faso for the treatment of asthma and conditions of inflammation. To evaluate its pharmacological properties and isolate the active compounds, a study through a bioguided phytochemical approach was conducted. This search was guided by a two-level investigation. First, we evaluated the impact of various fractions on the activity of enzymes involved in smooth muscle contraction (PDE4A1α) and inflammatory processes (PLA2 , 5-LOX). Second, we investigated the inhibitory effect of fractions on isolated rat trachea...
June 2014: Fundamental & Clinical Pharmacology
Florine Lecerf-Schmidt, Basile Peres, Glaucio Valdameri, Charlotte Gauthier, Evelyn Winter, Léa Payen, Attilio Di Pietro, Ahcène Boumendjel
ABCG2 impacts oral availability, tissue distribution and excretion of its substrates, including anticancer and anti-infectious drugs. Highly expressed at physiological barriers, its secretion level significantly controls drug distribution. Furthermore, its increased content into many types of cancer may lead to cell chemoresistance. Owing to the clinical relevance of ABCG2 in the multidrug resistance phenomenon, ABCG2 constitutes an appealing therapeutic target to increase drug distribution. Development of ABCG2 inhibitors can be used in combination with anticancer drugs to block the drug secretion from cancer cells...
June 2013: Future Medicinal Chemistry
Anne Doléans-Jordheim, Jean-Baptiste Veron, Olivier Fendrich, Emmanuelle Bergeron, Adrien Montagut-Romans, Yung-Sing Wong, Bianca Furdui, Jean Freney, Charles Dumontet, Ahcène Boumendjel
The NorA efflux pump lowers intracellular fluoroquinolone concentrations by expelling antibiotics through the membrane of Staphylococcus aureus. We identified 3-aryl-4-methyl-2-quinolin-2-ones as compounds able to restore the activity of the NorA substrate, ciprofloxacin, against resistant S. aureus strains, and acting as efflux pump inhibitors (EPI). In particular, 5-hydroxy-7-methoxy-4-methyl-3-phenylquinolin-2-one (6 c) presents both an EPI and an antimicrobial effect. Its efficacy and safety make it a potential candidate for further investigations...
April 2013: ChemMedChem
Alexandre Sostelly, Léa Payen, Jérôme Guitton, Attilio Di Pietro, Pierre Falson, Mylène Honorat, Ahcène Boumendjel, Annabelle Gèze, Gilles Freyer, Michel Tod
ATP-Binding Cassette transporters such as ABCG2 confer resistance to various anticancer drugs including irinotecan and its active metabolite, SN38. Early quantitative evaluation of efflux transporter inhibitors-cytotoxic combination requires quantitative drug-disease models. A proof-of-concept study has been carried out for studying the effect of a new ABCG2 transporter inhibitor, MBLI87 combined to irinotecan in mice xenografted with cells overexpressing ABCG2. Mice were treated with irinotecan alone or combined to MBLI87, and tumour size was periodically measured...
April 2014: Fundamental & Clinical Pharmacology
Tom Burke, Lisa Gluckstern
No abstract text is available yet for this article.
October 2012: Provider
Sarah Langmead
No abstract text is available yet for this article.
October 2012: Provider
Xinjie Lu, Min Xia, Valeria Endresz, Ildiko Faludi, Andrea Szabo, Eva Gonczol, Lakshmi Mundkur, Daxin Chen, Vijay Kakkar
AIMS: To assess whether immunizing Apob(tm2Sgy)Ldlr(tm1Her)J mice simultaneously with different atherosclerosis-related epitopes engineered in a single recombinant protein is effective in reducing atherosclerotic lesions. METHODS AND RESULTS: Antigenic epitopes were incorporated into a dendroaspin scaffold: AHC (ApoB100 peptide + hHSP60 peptide [hHSP60(153-163)] + putative epitope derived from Chlamydophila pneumoniae [Cpn]) and AHHC (AHC + hHSP60(303-312)); and were compared with construct A (ApoB peptide), construct H (hHSP60(153-163)), and construct AH (ApoB100 peptide + hHSP60(153-163))...
November 2012: Atherosclerosis
Inoka H Gamage, Arjan Jonker, David A Christensen, Peiqiang Yu
The objectives of this study were (1) to reveal the metabolic characteristics of proteins in different batches of feedstock (wheat) for bioethanol production and their co-products (wheat distillers dried grains with solubles, wDDGS) from the same bioethanol processing plant, and (2) to characterize biomolecular spectral profile associated with nutrient digestion in the rumen and intestine of dairy cattle. The metabolic characteristics of proteins were determined using the DVE/OEB system (where DVE=total truly absorbed protein supply, and OEB=degraded balance of protein) based on chemical profiles and rumen and intestinal digestion data from dairy cattle...
November 2012: Journal of Dairy Science
Romain Haudecoeur, Marine Peuchmaur, Abdelhakim Ahmed-Belkacem, Jean-Michel Pawlotsky, Ahcène Boumendjel
Hepatitis C is a viral liver infection considered as the major cause of cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C virus (HCV) possesses a single positive strand RNA genome encoding a polyprotein composed of approximatively 3000 amino acids. The polyprotein is cleaved at multiple sites by cellular and viral proteases to liberate structural and nonstructural (NS) proteins. NS5B, the RNA-dependent RNA polymerase (RdRp), which catalyzes the HCV RNA replication has emerged as an attractive target for the development of specifically targeted antiviral therapy for HCV (DAA, for direct-acting antivirals)...
September 2013: Medicinal Research Reviews
Alexandre Sostelly, Léa Payen, Jérôme Guitton, Attilio Di Pietro, Pierre Falson, Mylène Honorat, Glaucio Valdameri, Annabelle Geze, Ahcène Boumendjel, Gilles Freyer, Michel Tod
Efflux transporters play an important role in drug absorption and also in multidrug resistance. ABCG2 (BCRP) is an efflux transporter conferring cross-resistance to mitoxantrone (Mit), irinotecan (CPT11), and its active metabolite SN38. MBLI87, a new ABCG2 inhibitor has proven its efficacy against ABCG2-mediated efflux in vitro and in vivo. This work aimed at modeling and quantifying the cellular interaction between MBLI87 and different substrates using a mechanistic template model. An in vitro competition experiment study was carried out with HEK293 cells overexpressing ABCG2 exposed to fixed concentrations of substrates (Mit, CPT11, SN38) and to MBLI87 at several concentration levels...
October 2013: Fundamental & Clinical Pharmacology
Djillali Choubane, Amélie Rabot, Eric Mortreau, Jose Legourrierec, Thomas Péron, Fabrice Foucher, Youyou Ahcène, Sandrine Pelleschi-Travier, Nathalie Leduc, Latifa Hamama, Soulaiman Sakr
Light is a critical determinant of plant shape by controlling branching patterns and bud burst in many species. To gain insight into how light induces bud burst, we investigated whether its inductive effect in rose was related to gibberellin (GA) biosynthesis. In axillary buds of beheaded plants subject to light, the expression of two GA biosynthesis genes (RoGA20ox and RoGA3ox) was promptly and strongly induced, while that of a GA-catabolism genes (RoGA2ox) was reduced. By contrast, lower expression levels of these two GA biosynthesis genes were found in darkness, and correlated with a total inhibition of bud burst...
September 1, 2012: Journal of Plant Physiology
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