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https://www.readbyqxmd.com/read/29232795/-clinical-study-of-testicular-fasciotomy-for-testicular-torsion
#1
Seiji Nagasawa, Akihiro Kanematsu, Yasuhiro Shinkai, Kimihiro Shimatani, Takahiko Hashimoto, Yoshikazu Togo, Toru Suzuki, Shuken Go, Michio Nojima, Shingo Yamamoto
Between November 2011 and November 2014, we performed a tunica albuginea incision with tunica vaginalis flap coverage (TAI+TVFC) on 5 out of 15 patients who underwent surgery for testicular torsion. Of those 15 patients, 7 underwent orchidopexy alone (Group A), 5 underwent TAI+TVFC (Group B), and 3 underwent an orchidectomy procedure (Group C). All were followed for 1 year and preservation of testicular volume >50% on the contralateral side in ultrasound measurements was considered as salvaged. During the follow-up examinations, no testicular atrophy was noted in Group A...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29232732/high-salt-intake-promotes-different-responses-to-urodilatin-and-uroguanylin-in-the-isolated-rat-kidney
#2
Antonio Rafael Coelho Jorge, Pedro Henrique Sá Costa, Helena Serra Azul Monteiro, Manassés Claudino Fonteles
Urodilatin (UD) and uroguanylin (UGN) have been implicated in the regulation of salt and water homeostasis, particularly in the balance handling of salt intake. In this sense, the aim of the present work was to study the main effects of these peptides in kidneys from animals subjected to high NaCl (2%) intake, during 10 days in metabolic cages. The control group received only normal water, whereas the treated group drank 2% solution of NaCl (NaCl 2%). In addition, we studied effect of subthreshold UD (0.14 nM) and UGN (0...
December 12, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29232607/simultaneous-uplc-ms-ms-analysis-of-two-stable-isotope-labeled-versions-of-sucrose-in-mouse-plasma-and-brain-samples-as-markers-of-blood-brain-barrier-permeability-and-brain-vascular-space
#3
Ekram Ahmed Chowdhury, Faleh Alqahtani, Raktima Bhattacharya, Reza Mehvar, Ulrich Bickel
Blood Brain Barrier (BBB) permeability is frequently compromised in the course of diseases affecting the central nervous system (CNS). Sucrose is a low molecular weight, hydrophilic marker with slow permeability at the naive BBB and therefore one of the widely used indicators of barrier integrity. Our laboratory recently developed a highly sensitive UPLC-MS/MS method for stable isotope labeled [13C12]sucrose in biological matrices. Correction of total brain concentration for contribution of intravascular space is required in such experiments in order to accurately measure BBB permeability, and it is often accomplished by vascular perfusion with buffer solutions prior to brain sampling...
December 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29232293/pressure-and-flow-characteristics-of-a-novel-bidirectional-cannula-for-cardiopulmonary-bypass
#4
Yi Chen, Elli Tutungi, James McMillan, Sara M Tayeh, Jess K Underwood, Adam C Wells, Julian A Smith, Randall A Moshinsky
OBJECTIVE: Femoral arterial cannulation is associated with a significant risk of lower limb ischemia. The aim of the study was to assess the pressure and flow in the femoral artery using a novel bidirectional femoral cannula in a sheep model of peripheral cardiopulmonary bypass. METHODS: Peripheral cardiopulmonary bypass was established using a multistage venous cannula inserted into the internal jugular vein and the bidirectional or a conventional arterial cannula into the femoral artery in seven adult ewes...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29232172/halo-202-randomized-phase-ii-study-of-pegph20-plus-nab-paclitaxel-gemcitabine-versus-nab-paclitaxel-gemcitabine-in-patients-with-untreated-metastatic-pancreatic-ductal-adenocarcinoma
#5
Sunil R Hingorani, Lei Zheng, Andrea J Bullock, Tara E Seery, William P Harris, Darren S Sigal, Fadi Braiteh, Paul S Ritch, Mark M Zalupski, Nathan Bahary, Paul E Oberstein, Andrea Wang-Gillam, Wilson Wu, Dimitrios Chondros, Ping Jiang, Sihem Khelifa, Jie Pu, Carrie Aldrich, Andrew E Hendifar
Purpose Metastatic pancreatic ductal adenocarcinoma is characterized by excessive hyaluronan (HA) accumulation in the tumor microenvironment, elevating interstitial pressure and impairing perfusion. Preclinical studies demonstrated pegvorhyaluronidase alfa (PEGPH20) degrades HA, thereby increasing drug delivery. Patients and Methods Patients with previously untreated metastatic pancreatic ductal adenocarcinoma were randomly assigned to treatment with PEGPH20 plus nab-paclitaxel/gemcitabine (PAG) or nab-paclitaxel/gemcitabine (AG)...
December 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29232024/myocardial-perfusion-reserve-index-in-children-with-kawasaki-disease
#6
Richard M Friesen, Michal Schäfer, Pei-Ni Jone, Nana Appiawiah, Daniel Vargas, Brian Fonseca, Michael V DiMaria, Uyen Truong, LaDonna Malone, Lorna P Browne
BACKGROUND: Coronary artery lesions in patients with Kawasaki disease (KD) can impair myocardial perfusion, yet evaluation of perfusion defects by cardiac magnetic resonance (MR) in children is often qualitative. PURPOSE: In this study we aimed to use a quantitative method of myocardial perfusion using stress cardiac MR-derived myocardial perfusion reserve index (MPRI) in children with KD and compare MPRI with ventricular mechanical performance evaluated by cardiac MR strain analysis...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29231185/quantitative-evaluation-of-graded-hindlimb-ischemia-based-on-pharmacokinetic-modelling-and-hemodynamic-analysis-of-indocyanine-green
#7
Wenjuan Cai, Yongshuai Li, Fei Liu, Jianwen Luo
OBJECTIVE: Accurate evaluation of the degree of hindlimb ischemia is challenging but essential for the diagnosis and treatment of peripheral vascular insufficiency. The aim of the study is to apply a multiparametric method for the quantitative estimation of mouse models with different degrees of hindlimb ischemia based on a dynamic fluorescence imaging-based strategy. APPROACH: An adjustable hydraulic occluder was placed around the thigh root of one hindlimb to induce six different degrees of hindlimb ischemia...
December 12, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29231040/differentiation-between-phyllodes-tumors-and-fibroadenomas-using-intravoxel-incoherent-motion-magnetic-resonance-imaging-comparison-with-conventional-diffusion-weighted-imaging
#8
Hiroko Kawashima, Tosiaki Miyati, Naoki Ohno, Masako Ohno, Masafumi Inokuchi, Hiroko Ikeda, Toshifumi Gabata
OBJECTIVE: To investigate whether the parameters derived from intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) could differentiate phyllodes tumors (PTs) from fibroadenomas (FAs) by comparing the apparent diffusion coefficient (ADC) values. METHODS: This retrospective study included seven FAs, 10 benign PTs (BPTs), four borderline PTs, and one malignant PT. Biexponential analyses of IVIM were performed using a 3 T MRI scanner. Quantitative IVIM parameters (pure diffusion coefficient [D], perfusion-related diffusion coefficient [D*], and fraction [f]) were calculated...
December 12, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29230960/ciq-a-positive-allosteric-modulator-of-glun2c-d-containing-n-methyl-d-aspartate-receptors-rescues-striatal-synaptic-plasticity-deficit-in-a-mouse-model-of-parkinson-s-disease
#9
Mona Nouhi, Xiaoqun Zhang, Ning Yao, Karima Chergui
AIMS: To investigate if CIQ, a positive allosteric modulator of N-methyl-d-aspartate receptors (NMDARs) containing GluN2C/D subunits, rescues the loss of long-term potentiation (LTP) and forelimb-use asymmetry in a mouse model of Parkinson's disease (PD). METHODS: We have used electrophysiology in brain slices and the cylinder test to examine the effect of CIQ on glutamatergic synaptic transmission, synaptic plasticity, and forelimb-use in the unilateral 6-hydroxydopamine-lesion mouse model of PD...
December 11, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29230939/normative-values-and-factors-affecting-water-perfused-esophageal-high-resolution-impedance-manometry-for-a-chinese-population
#10
P-H Tseng, R K M Wong, J-F Wu, C-C Chen, C-H Tu, Y-C Lee, H-C Lee, H-P Wang, M-S Wu
BACKGROUND: Combined esophageal high-resolution impedance manometry (HRIM) measures multiple pressures and bolus transit simultaneously, facilitating detailed assessment of esophageal motility. Currently, normative values for water-perfused HRIM systems for Chinese populations are lacking. METHODS: Healthy volunteers were enrolled for comprehensive anthropometric measures, blood biochemistry tests, and an HRIM study using 22 water-perfused pressure sensors and 12 impedance channels...
December 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29230607/the-effect-of-high-count-rates-on-cardiac-perfusion-quantification-in-a-simultaneous-pet-mr-system-using-a-cardiac-perfusion-phantom
#11
Jim O' Doherty, Zacharias Chalampalakis, Paul Schleyer, Muhummad Sohaib Nazir, Amedeo Chiribiri, Paul K Marsden
BACKGROUND: PET-MRI is under investigation as a new strategy for quantitative myocardial perfusion imaging. Consideration is required as to the maximum scanner count rate in order to limit dead-time losses resulting from administered activity in the scanner field of view during the first pass of the radiotracer. RESULTS: We performed a decaying-source experiment to investigate the high count-rate performance of a PET-MR system (Siemens mMR) over the expected range of activities during a clinical study...
December 11, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29230591/intraoperative-use-of-icg-fluorescence-imaging-to-reduce-the-risk-of-anastomotic-leakage-in-colorectal-surgery-a-systematic-review-and-meta-analysis
#12
REVIEW
R Blanco-Colino, E Espin-Basany
BACKGROUND: Indocyanine green (ICG) fluorescence imaging has been proven to be an effective tool to assess anastomotic perfusion. The aim of this systematic review and meta-analysis was to evaluate its efficacy in reducing the anastomotic leakage (AL) rate after colorectal surgery. METHODS: PubMed, Scopus, WOS, Google Scholar and Cochrane Library were searched up to January 2017 for studies comparing fluorescence imaging with standard care. ClinicalTrials.gov register was searched for ongoing trials...
December 11, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29230571/correlation-of-left-ventricular-dyssynchrony-on-gated-myocardial-perfusion-spect-analysis-with-extent-of-late-gadolinium-enhancement-on-cardiac-magnetic-resonance-imaging-in-hypertrophic-cardiomyopathy
#13
Hideaki Yuki, Daisuke Utsunomiya, Shinya Shiraishi, Seiji Takashio, Fumi Sakamoto, Noriko Tsuda, Seitaro Oda, Masafumi Kidoh, Takeshi Nakaura, Kenichi Tsujita, Yasuyuki Yamashita
Myocardial perfusion-single-photon emission computed tomography (MP-SPECT) is used to evaluate microvascular dysfunction and coexisting coronary artery disease in patients with hypertrophic cardiomyopathy (HCM). Phase analysis in gated MP-SPECT can provide additional information on left ventricular (LV) dyssynchrony, while the extent of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging is an important prognostic factor in patients with HCM. We, therefore, sought to investigate the relationship of dyssynchrony by phase analysis on gated MP-SPECT and LGE on CMR imaging in 22 patients with HCM who underwent both stress/rest-gated MP-SPECT and contrast-enhanced CMR imaging...
December 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29230490/pharmacokinetic-study-of-tianeptine-and-its-active-metabolite-mc5-in-rats-following-different-routes-of-administration-using-a-novel-liquid-chromatography-tandem-mass-spectrometry-analytical-method
#14
Małgorzata Szafarz, Agnieszka Wencel, Krzysztof Pociecha, Filip A Fedak, Piotr Wlaź, Elżbieta Wyska
Tianeptine is an atypical antidepressant with a unique mechanism of action and recently it has been also reported that its major metabolite, compound MC5, possesses pharmacological activity similar to that of the parent drug. The current study aims to investigate the pharmacokinetics (PK) of both tianeptine and MC5 after intravenous or intraperitoneal administration of the parent drug as well as the metabolic ratio of MC5 in rats. To achieve these goals an LC-MS/MS method using the small sample volume for the quantitation of tianeptine and its active metabolite MC5 in rat plasma and liver perfusate has been developed and validated...
December 12, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29229895/prevalence-and-predictors-of-myocardial-ischemia-by-preoperative-myocardial-perfusion-single-photon-emission-computedtomography-in-patients-undergoing-noncardiac-surgery
#15
Abdelkareem Saleh Al-Oweidi, Hesham Albabtain, Suleiman M Kharabsheh, Peter Kimme, Mahmoud Almustafa, Samer Seder, Mohamed Shoukri, Ahmed L Fathala
BACKGROUND: The prevalence and predictors of myocardial ischemia before noncardiac surgery are unknown. In addition the predictive value of myocardial perfusion single-photon emission computed tomography (SPECT) before noncardiac in individual patients is uncertain. OBJECTIVE: Evaluate the prevalence and predictors of myocardial ischemia before noncardiac surgery, and determine the postoperative cardiac outcome based on results of myocardial perfusion SPECT. DESIGN: Retrospective...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229756/decoding-the-molecular-switches-of-natriuretic-peptides-which-differentiate-its-vascular-and-renal-functions
#16
Sindhuja Sridharan, R Manjunatha Kini
Heart failure (HF) is associated with high morbidity and mortality. Dysfunction of blood pressure and/or volume homeostatic processes result in lower perfusion and/or congestion. Treatment strategies exerting differential effects on pressure and volume mechanisms are critical in handling patients with HF. Atrial natriuretic peptides (ANP) is a key hormone in maintaining circulation. It binds to NP receptor-A (NPR-A) on vasculature, kidneys and nervous system to lowers blood pressure and volume. It exerts a concentration-dependent pharmacological activity; only increased renal excretion of water and sodium at low doses and vasodilation along with renal effects at slightly higher doses...
December 11, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29229555/reduced-cerebrovascular-reactivity-and-increased-resting-cerebral-perfusion-in-rats-exposed-to-a-cafeteria-diet
#17
Mariana Gomez-Smith, Rafal Janik, Evelyn M Lake, Lynsie A M Thomason, Conner Adams, Matthew S Jeffers, Bojana Stefanovic, Dale Corbett
To better understand the effects of a diet high in fat, sugar, and sodium on cerebrovascular function, Sprague Dawley rats were chronically exposed to a Cafeteria diet. Resting cerebral perfusion and cerebrovascular reactivity were quantified using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI). In addition, structural changes to the cerebrovasculature and susceptibility to ischemic lesion were examined. Compared to control animals fed standard chow (SD), Cafeteria diet (CAF) rats exhibited increased resting brain perfusion in the hippocampus and reduced cerebrovascular reactivity in response to 10% inspired CO2 challenges in both the hippocampus and the neocortex...
December 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/29229444/neural-control-of-choroidal-blood-flow
#18
REVIEW
Anton Reiner, Malinda E C Fitzgerald, Nobel Del Mar, Chunyan Li
The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal information centrally and act locally to vasodilate and increase choroidal blood flow...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29229331/an-integrated-precipitation-and-ion-exchange-chromatography-process-for-antibody-manufacturing-process-development-strategy-and-continuous-chromatography-exploration
#19
Steffen Großhans, Gang Wang, Christian Fischer, Jürgen Hubbuch
In the past decades, research was carried out to find cost-efficient alternatives to Protein A chromatography as a capture step in monoclonal antibody (mAb) purification processes. In this work, polyethylene glycol (PEG) precipitation has shown promising results in the case of mAb yield and purity. Especially with respect to continuous processing, PEG precipitation has many advantages, like low cost of goods, simple setup, easy scalability, and the option to handle perfusion reactors. Nevertheless, replacing Protein A has the disadvantage of renouncing a platform unit operation as well...
December 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29229261/preliminary-experience-in-combined-somatic-and-cerebral-oximetry-monitoring-in-liver-transplantation
#20
Tina Hu, Yves Collin, Réal Lapointe, François Martin Carrier, Luc Massicotte, Annik Fortier, Jean Lambert, Franck Vandenbroucke-Menu, André Y Denault
OBJECTIVE: The use of cerebral near-infrared spectroscopy (NIRS) has become widespread in cardiac surgery after research demonstrated an association between perioperative cerebral desaturations and postoperative complications. Somatic NIRS desaturation also is associated with an increased risk of postoperative complications and mortality. The objective of this study was to explore the trends of both somatic and cerebral NIRS during liver transplantation. DESIGN: A prospective, single-site, observational case series...
July 20, 2017: Journal of Cardiothoracic and Vascular Anesthesia
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