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https://www.readbyqxmd.com/read/29909558/blood-brain-barrier-permeability-assessed-by-perfusion-computed-tomography-predicts-hemorrhagic-transformation-in-acute-reperfusion-therapy
#1
Taewon Kim, Jaseong Koo, Seong-Hoon Kim, In-Uk Song, Sung-Woo Chung, Kwang-Soo Lee
Hemorrhagic transformation (HT) is one of the most feared complications of acute recanalization therapies. The aim of this study was to evaluate whether blood-brain barrier permeability (BBBP) imaging can predict HT in the setting of acute recanalization therapy and to determine the sensitivity and specificity of BBBP for the prediction of HT according to the type of reperfusion therapy. We assessed a total of 46 patients who received recanalization therapy (intravenous (IV) recombinant tissue plasminogen activator (tPA), mechanical thrombectomy with a stent retriever or both) for acute ischemic stroke within the internal carotid artery or middle cerebral artery...
June 16, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29909547/modulation-of-mg-2-influx-and-cytoplasmic-free-mg-2-concentration-in-rat-ventricular-myocytes
#2
Michiko Tashiro, Hana Inoue, Masato Konishi
To examine whether TRPM7, a member of the melastatin family of transient receptor potential channels, is a physiological pathway for Mg2+ entry in mammalian cells, we studied the effect of TRPM7 regulators on cytoplasmic free Mg2+ concentration ([Mg2+ ]i ) of rat ventricular myocytes. Acutely isolated single cells were AM-loaded with the fluorescent indicator furaptra, and [Mg2+ ]i was estimated at 25 °C. After [Mg2+ ]i was lowered by soaking the cells with a high-K+ and Mg2+ -Ca2+ -free solution, [Mg2+ ]i was recovered by extracellular perfusion of Ca2+ -free Tyrode's solution that contained 1 mM Mg2+ ...
June 16, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29909103/prrospective-comparison-of-ffr-derived-from-coronary-ct-angiography-with-spect-perfusion-imaging-in-stable-coronary-artery-disease-the-reassess-study
#3
Niels Peter Rønnow Sand, Karsten Tange Veien, Søren Steen Nielsen, Bjarne Linde Nørgaard, Pia Larsen, Allan Johansen, Søren Hess, Lone Deibjerg, Majed Husain, Anders Junker, Kristian Korsgaard Thomsen, Allan Rohold, Lisette Okkels Jensen
OBJECTIVES: This study sought to compare the per-patient diagnostic performance of coronary computed tomography angiography (CTA)-derived fractional flow reserve (FFRCT ) with that of single-photon emission computed tomography (SPECT), using a fractional flow reserve (FFR) value of ≤0.80 as the reference for diagnosing at least 1 hemodynamically significant stenosis in a head-to-head comparison of patients with intermediate coronary stenosis as determined by coronary CTA. BACKGROUND: No previous study has prospectively compared the diagnostic performance of FFRCT and myocardial perfusion imaging by SPECT in symptomatic patients with intermediate range coronary artery disease (CAD)...
June 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909101/lipoprotein-apheresis-acutely-reverses-coronary-microvascular-dysfunction-in-patients-with-severe-hypercholesterolemia
#4
Melinda D Wu, Federico Moccetti, Eran Brown, Brian P Davidson, Tamara Atkinson, J Todd Belcik, George Giraud, P Barton Duell, Sergio Fazio, Hagai Tavori, Sotirios Tsimikas, Jonathan R Lindner
OBJECTIVES: The study evaluated whether lipoprotein apheresis produces immediate changes in resting perfusion in subjects with severe hypercholesterolemia, and whether there is a difference in the response between peripheral and coronary microcirculations. BACKGROUND: Lipoprotein apheresis is used in patients with severe hypercholesterolemia to reduce plasma levels of low-density lipoprotein cholesterol. METHODS: Quantitative contrast-enhanced ultrasound perfusion imaging of the myocardium at rest and skeletal muscle at rest and during calibrated contractile exercise was performed before and immediately after lipoprotein apheresis in 8 subjects with severe hypercholesterolemia, 7 of whom had a diagnosis of familial hypercholesterolemia...
June 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29908993/priors-guided-slice-wise-adaptive-outlier-cleaning-for-arterial-spin-labeling-perfusion-mri
#5
Yiran Li, Sudipto Dolui, Dan-Feng Xie, Ze Wang
BACKGROUND: Due to the low signal-to-noise-ratio (SNR) and unavoidable head motions, the pairwise subtraction perfusion signal extraction process in arterial spin labeling (ASL) perfusion MRI can produce extreme outliers. COMPARISON WITH EXISTING METHODS: We previously proposed an adaptive outlier cleaning (AOC) algorithm for ASL MRI. While it performed well even for clinical ASL data, two issues still exist. One is that if the reference is already dominated by noise, outlier cleaning using low correlation with the mean as a rejection criterion will actually reject the less noisy samples but keep the more noisy ones...
June 14, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29908978/feasibility-of-intravoxel-incoherent-motion-for-differentiating-benign-and-malignant-thyroid-nodules
#6
Hui Tan, Jun Chen, Yi Ling Zhao, Jin Huan Liu, Liang Zhang, Chang Sheng Liu, Dongjie Huang
RATIONALE AND OBJECTIVES: This study aimed to preliminarily investigate the feasibility of intravoxel incoherent motion (IVIM) theory in the differential diagnosis of benign and malignant thyroid nodules. MATERIALS AND METHODS: Forty-five patients with 56 confirmed thyroid nodules underwent preoperative routine magnetic resonance imaging and IVIM diffusion-weighted imaging. The histopathologic diagnosis was confirmed by surgery. Apparent diffusion coefficient (ADC), perfusion fraction f, diffusivity D, and pseudo-diffusivity D* were quantified...
June 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29908928/a-novel-muscle-transfer-for-independent-digital-control-of-a-myoelectric-prosthesis-the-starfish-procedure
#7
R Glenn Gaston, John W Bracey, Mark A Tait, Bryan J Loeffler
Control of independent digital flexion and extension has remained an elusive goal in myoelectric prosthetics for upper extremity amputees. We first performed a cadaver study to determine the feasibility of transferring the interossei muscles for each digit to the dorsum of the hand without damaging the neurovascular pedicles. Once this capability was ensured, a clinical case was performed transferring the interossei of the middle and ring fingers to the dorsum of the hand where they could serve as a myoelectric signal for a partial hand amputee to allow individual digital control with a myoelectric prosthesis...
June 13, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29908637/dce-mri-reveals-early-decreased-and-later-increased-placenta-perfusion-after-a-stress-challenge-during-pregnancy-in-a-mouse-model
#8
Chressen Catharina Remus, Fabian Kording, Petra Arck, Emilia Solano, Jan Sedlacik, Gerhard Adam, Kurt Hecher, Nils Daniel Forkert
OBJECTIVES: Stress during pregnancy is known to have negative effects on fetal outcome. The purpose of this exploratory study was to examine placental perfusion alterations after stress challenge during pregnancy in a mouse model. MATERIAL AND METHODS: Seven Tesla MRI was performed on pregnant mice at embrionic day (ED) 14.5 and 16.5. Twenty dams were exposed to an established acoustic stress challenge model while twenty non-exposed dams served as controls. Placental perfusion was analyzed in dynamic contrast-enhanced (DCE) MRI using the steepest slope model...
May 2018: Placenta
https://www.readbyqxmd.com/read/29908049/imaging-sublingual-microcirculatory-perfusion-in-pediatric-patients-receiving-procedural-sedation-with-propofol-a-pilot-study
#9
M A Riedijk, D M J Milstein
OBJECTIVE: Procedural sedation with propofol is widely used in the pediatric population. A well-known side effect of propofol is a decrease of peripheral vascular resistance resulting in hypotension, but little is known about the effects on the microcirculation in humans. We aimed to evaluate the effects of propofol on the sublingual microcirculatory perfusion by continuous video imaging in pediatric patients undergoing procedural sedation. METHODS: Patients admitted to the Pediatric Intensive Care Unit for procedural sedation were recruited...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908046/sepsis-induced-acute-kidney-injury-a-disease-of-the-microcirculation
#10
Shuai Ma, Roger G Evans, Naoya Iguchi, Marianne Tare, Helena C Parkington, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva
Acute kidney injury (AKI) is a common complication of sepsis and is significantly associated with mortality. Sepsis accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The pathogenesis of septic AKI is complex, but there is emerging evidence that, at least in the first 48 hours, the defects may be functional rather than structural in nature. For example, septic AKI is associated with an absence of histopathological changes, but with microvascular abnormalities and tubular stress...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908041/automated-quantification-of-microvascular-perfusion
#11
P Mason McClatchey, Nicholas A Mignemi, Zhengang Xu, Ian M Williams, Jane E B Reusch, Owen P McGuinness, David H Wasserman
OBJECTIVE: Changes in microvascular perfusion have been reported in many diseases, yet the functional significance of altered perfusion is often difficult to determine. This is partly because commonly used techniques for perfusion measurement often rely on either indirect or by-hand approaches. METHODS: We developed and validated a fully automated software technique to measure microvascular perfusion in videos acquired by fluorescence microscopy in the mouse gastrocnemius...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29907933/the-effect-of-time-of-flight-and-point-spread-function-modeling-on-82-rb-myocardial-perfusion-imaging-of-obese-patients
#12
Paul K R Dasari, Judson P Jones, Michael E Casey, Yuanyuan Liang, Vasken Dilsizian, Mark F Smith
BACKGROUND: The effect of time-of-flight (TOF) and point spread function (PSF) modeling in image reconstruction has not been well studied for cardiac PET. This study assesses their separate and combined influence on 82 Rb myocardial perfusion imaging in obese patients. METHODS: Thirty-six obese patients underwent rest-stress 82 Rb cardiac PET. Images were reconstructed with and without TOF and PSF modeling. Perfusion was quantitatively compared using the AHA 17-segment model for patients grouped by BMI, cross-sectional body area in the scanner field of view, gender, and left ventricular myocardial volume...
June 15, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29907855/diagnostic-yield-and-accuracy-of-coronary-ct-angiography-after-abnormal-nuclear-myocardial-perfusion-imaging
#13
Felix G Meinel, U Joseph Schoepf, Jacob C Townsend, Brian A Flowers, Lucas L Geyer, Ullrich Ebersberger, Aleksander W Krazinski, Wolfgang G Kunz, Kolja M Thierfelder, Deborah W Baker, Ashan M Khan, Valerian L Fernandes, Terrence X O'Brien
We aimed to determine the diagnostic yield and accuracy of coronary CT angiography (CCTA) in patients referred for invasive coronary angiography (ICA) based on clinical concern for coronary artery disease (CAD) and an abnormal nuclear stress myocardial perfusion imaging (MPI) study. We enrolled 100 patients (84 male, mean age 59.6 ± 8.9 years) with an abnormal MPI study and subsequent referral for ICA. Each patient underwent CCTA prior to ICA. We analyzed the prevalence of potentially obstructive CAD (≥50% stenosis) on CCTA and calculated the diagnostic accuracy of ≥50% stenosis on CCTA for the detection of clinically significant CAD on ICA (defined as any ≥70% stenosis or ≥50% left main stenosis)...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907232/intramuscular-e-selectin-adeno-associated-virus-gene-therapy-promotes-wound-healing-in-an-ischemic-mouse-model
#14
Punam P Parikh, Roberta M Lassance-Soares, Hongwei Shao, Manuela M Regueiro, Yan Li, Zhao-Jun Liu, Omaida C Velazquez
BACKGROUND: Poor wound healing in critical limb ischemia (CLI) is attributed to impaired neovascularization and reperfusion. Optimizing the ischemic wound with adhesion molecules that enhance stem cell homing may revolutionize treatment. The purpose of this study is to test the efficacy of adhesion molecule E-selectin on wound healing in an ischemic mouse wound. METHODS: Adult FVB/NJ mice underwent unilateral femoral artery and vein ligation to induce CLI. A 4-mm punch biopsy wound was created on the anterior thigh to simulate ischemic wounds...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907219/effects-of-a%C3%A3-a%C3%A3-and-cilostazol-on-skin-microcirculation-and-viability-of-tram-flaps-in-hamsters
#15
Denise S Coelho da Mota, Fernando L Sicuro, Angela C Resende, Roberto S De Moura, Daniel A Bottino, Eliete Bouskela
BACKGROUND: Tissue necrosis caused by insufficient perfusion is a major complication in flap transfer. This study evaluated whether treatment with cilostazol or hydroalcoholic extract of seeds of Euterpe oleracea Mart. (açaí) protects the transverse rectus abdominis myocutaneous (TRAM) flap against ischemic damage in hamsters. MATERIALS AND METHODS: Fifty-four hamsters were divided into three oral treatment groups: placebo, açaí, or cilostazol. Caudally based, unipedicled TRAM flaps were raised, sutured back, classified into four vascular zones (I-IV), and evaluated for tissue viability, capillary blood flow (CBF), perfused vessel density (PVD), and microvascular flow index (MFI) by orthogonal polarization spectral imaging at three time points: immediately postoperatively (IPO), 24 h postoperatively (24hPO), and 7 d postoperatively (7POD)...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907130/acute-kidney-injury-is-associated-with-a-decrease-in-cortical-renal-perfusion-during-septic-shock
#16
Anatole Harrois, Nicolas Grillot, Samy Figueiredo, Jacques Duranteau
BACKGROUND: Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contrast enhanced ultrasound (CEUS). METHODS: We prospectively included 20 ICU patients with septic shock and 10 control patients (CL) without septic shock admitted to a surgical ICU. Cortical renal perfusion was evaluated with CEUS during continuous infusion of Sonovue (Milan, Italy) within the first 24 h (day 0), between 24 and 48 h (day 1) and after 72 h (day 3) of care...
June 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29906665/reproductive-performance-of-bos-indicus-beef-cows-treated-with-different-doses-of-equine-chorionic-gonadotropin-at-the-end-of-a-progesterone-estrogen-based-protocol-for-fixed-time-artificial-insemination
#17
Rafael Herrera Alvarez, Guilherme Pugliesi, Fabio Luis Nogueira Natal, Cecilia Constantino Rocha, Gilmar Arantes Ataide Júnior, Alfredo José Ferreira Melo, Ivani Posar Otzuk, Claudio Alvarenga de Oliveira, Patrice Humblot
Two experiments were performed to evaluate the reproductive performance of zebu beef cows treated with different doses of eCG at the end of a progesterone (P4)/estrogen based protocol for timed artificial insemination (TAI). In Experiment 1, suckling Bos indicus Nelore cows (n = 261) received, on day 0, a progesterone (P4) intravaginal device (PD) and an injection of 1 mg estradiol benzoate (EB). On day 8, the PD was removed, 500 μg of cloprostenol was injected, and cows were assigned to one of the following groups: Control (no treatment), 300 (300 IU of eCG), 600 (600 IU of eCG), and 900 (900 IU of eCG)...
June 8, 2018: Theriogenology
https://www.readbyqxmd.com/read/29905609/double-supercharged-jejunal-interposition-for-late-salvage-of-long-gap-esophageal-atresia
#18
Ingrid M Ganske, Joseph M Firriolo, Laura C Nuzzi, Oren Ganor, Thomas E Hamilton, C Jason Smithers, Russell W Jennings, Joseph Upton, Brian I Labow, Amir H Taghinia
BACKGROUND: A variety of surgical techniques exist to manage long-gap esophageal atresia (LGEA), including gastric pull-up (GPU), colonic interposition (CI), jejunal interposition (JI), and distraction lengthening. Salvage reconstruction for late failure of any conduit type is a complex surgical problem fraught with technical difficulty and significant risk. Jejunal interposition can be used as a salvage procedure in the management of LGEA. However, the opposing requirements of conduit length and adequate perfusion make the procedure technically challenging...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29905602/primary-closure-of-wide-fasciotomy-and-surgical-wounds-using-rubber-band-assisted-external-tissue-expansion-a-simple-safe-and-cost-effective-technique
#19
Elizabeth M Kenny, Francesco M Egro, James M Russavage, Alexander M Spiess, Tahsin Oğuz Acartürk
BACKGROUND: Although decompressive fasciotomy is a limb-saving procedure in the setting of acute compartment syndrome, it leaves a large wound defect with tissue edema and skin retraction that can preclude primary closure. Numerous techniques have been described to address the challenge of closing fasciotomy wounds. This study reports our experience with fasciotomy closure using rubber bands (RBs) for external tissue expansion. METHODS: Patients were informed about RB closure and split-thickness skin graft options...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29905541/use-of-perfusion-mri-for-determination-of-irradiation-volumes-in-radiotherapy-of-patients-with-brain-glioma
#20
K Mardaleishvili, G Orkodashvili
Objective - to assess how rCBV maps correlate with irradiation treatment plans in patients with recurrent tumor in order to identify potential differences and optimize treatment planning. 11 patients with brain HGG have taken participation in this study. Study was conducted in Radiation Medicine Center and Scientific Research Institute of Clinical Medicine. All patients underwent DSC-MRI and routine MRI imaging prior to re-irradiation treatment planning, and underwent treatment as per routine clinical protocol...
May 2018: Georgian Medical News
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