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https://www.readbyqxmd.com/read/28825193/differential-expression-of-transforming-growth-factor-beta1-connective-tissue-growth-factor-phosphorylated-smad2-3-and-phosphorylated-erk1-2-during-mouse-tooth-development
#1
Shubo Li, Yihuai Pan
Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta 1 (TGF-β1) and TGF-β1-induced CTGF expression is regulated through SMAD and mitogen-activated protein kinase (MAPK) signaling pathways. The fine modulation of TGF-β1 signaling is very important to the process of tooth development. However, little is known about the localization of CTGF, MAPK and SMAD in the context of TGF-β1 signaling during odontogenesis. Hence, we aimed to investigate the expression of TGF-β1, CTGF, phosphorylated-SMAD2/3 (p-SMAD2/3) and phosphorylated-ERK1/2 (p-ERK1/2)...
August 19, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28824898/the-sex-and-gender-intersection-in-chronic-periodontitis
#2
Effie Ioannidou
Periodontitis, a complex polymicrobial inflammatory disease, is a public health burden affecting more than 100 million people and being partially responsible for tooth loss. Interestingly, periodontitis has a documented higher prevalence in men as compared to women signifying a possible sex/gender entanglement in the disease pathogenesis. Although relevant evidence has treated sex/gender in a simplistic dichotomous manner, periodontitis may represent a complex inflammatory disease model, in which sex biology may interfere with gender social and behavioral constructs affecting disease clinical phenotype...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28824450/regulators-of-collagen-fibrillogenesis-during-molar-development-in-the-mouse
#3
Ivana Zvackova, Eva Matalova, Herve Lesot
Development of mammalian teeth and surrounding tissues includes time-space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling. Fibril-associated collagens with interrupted triple helices (FACITs) and a group of small leucine-rich proteoglycans (SLRPs) are involved in the regulation of collagen fibrillogenesis. Recently, collagen type XII and collagen type XIV, members of the FACITs family, were found in the peridental mesenchyme contributing to alveolar bone formation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28824445/molar-hypomineralisation-a-call-to-arms-for-enamel-researchers
#4
Michael J Hubbard, Jonathan E Mangum, Vidal A Perez, Garry J Nervo, Roger K Hall
Developmental dental defects (DDDs, hereafter "D3s") hold significance for scientists and practitioners from both medicine and dentistry. Although, attention has classically dwelt on three other D3s (amelogenesis imperfecta, dental fluorosis, and enamel hypoplasia), dental interest has recently swung toward Molar Hypomineralisation (MH), a prevalent condition characterised by well-delineated ("demarcated") opacities in enamel. MH imposes a significant burden on global health and has potential to become medically preventable, being linked to infantile illness...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28823708/combined-anatomical-variations-the-mylohyoid-bridge-retromolar-canal-and-accessory-palatine-canals-branched-from-the-canalis-sinuosus
#5
M C Rusu, M Săndulescu, C Bichir, L A S Muntianu
The study of anatomical variations is important not only for collecting anthropometric data, but also for improving clinical protocols and understanding why a particular clinical procedure sometimes does not yield the expected results. We report the case of a 74 year-old patient, in which we observed combined anatomical variants of the mandible and maxillary bone. One of these was the unilateral mylohyoid bridge (MB) of the uncommon, lingular type. This MB extended posteriorly to the spine of Spix, over the sulcus colli behind the spine...
August 16, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28823648/patterns-of-integration-in-the-canine-skull-an-inside-view-into-the-relationship-of-the-skull-modules-of-domestic-dogs-and-wolves
#6
Stefan Curth, Martin S Fischer, Kornelius Kupczik
The skull shape variation in domestic dogs exceeds that of grey wolves by far. The artificial selection of dogs has even led to breeds with mismatching upper and lower jaws and maloccluded teeth. For that reason, it has been advocated that their skulls (including the teeth) can be divided into more or less independent modules on the basis of genetics, development or function. In this study, we investigated whether the large diversity of dog skulls and the frequent occurrence of orofacial disproportions can be explained by a lower integration strength between the modules of the skull and by deviations in their covariation pattern when compared to wolves...
August 17, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28823063/glass-ceramic-cad-cam-crowns-and-severely-altered-posterior-teeth-a-three-levels-study
#7
Michel Fages, Stephane Corn, Pierre Slangen, Jacques Raynal, Patrick Ienny, Kinga Turzo, Frederic Cuisinier, Jean-Cédric Durand
For many practitioners, longevity of full glass ceramic crowns in the posterior area, molars and premolars, remains a real challenge. The purpose of this article is to identify and evaluate the parameters that can significantly influence their resistance when preparing a tooth. The analysis proposed in this article relies on interrelated studies conducted at three levels: in vitro (mechanical tests), in silico (finite elements simulations) and in vivo (clinical survival rates). The in vitro and the in silico studies proved that an appropriate variation of the geometric design of the preparations enables to increase up to 80% the mechanical strength of ceramic reconstructions...
August 19, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28822567/classification-and-clinical-management-of-retrograde-peri-implantitis-associated-with-apical-periodontitis-a-proposed-classification-system-and-case-report
#8
Nima D Sarmast, Howard H Wang, Ali S Sajadi, Nikola Angelov, Samuel O Dorn
Biological complications involving dental implants include peri-implant diseases such as peri-implant mucositis and peri-implantitis. The latter presents with progressive bone loss from the alveolar crest in a coronal apical direction. However, a separate disease entity termed retrograde peri-implantitis (RPI), which presents with progressive bone loss at the periapex of the implant, also exists and may be of particular interest to endodontists because it typically presents with periapical pathology of both the implant and adjacent tooth or at a site that previously housed an endodontically treated tooth...
August 16, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28822565/the-influence-of-periodontal-status-on-endodontically-treated-teeth-9-year-survival-analysis
#9
Navid Khalighinejad, Anita Aminoshariae, James C Kulild, Jeannie Wang, Andre Mickel
INTRODUCTION: The aim of this study was to investigate the effect of periodontal status at the time of nonsurgical root canal treatment (NSRCT) on the survival rate of endodontically treated teeth (ETT). METHODS: In this retrospective investigation, molars that received NSRCT in an advanced specialty education program in endodontics from 2009 through 2017 were initially recruited. After the application of inclusion and exclusion criteria, 315 teeth were included in the study...
August 16, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28821826/osteocyte-regulation-of-orthodontic-force-mediated-tooth-movement-via-rankl-expression
#10
Ayumi Shoji-Matsunaga, Takehito Ono, Mikihito Hayashi, Hiroshi Takayanagi, Keiji Moriyama, Tomoki Nakashima
Orthodontic tooth movement is achieved by the remodeling of the alveolar bone surrounding roots of teeth. Upon the application of orthodontic force, osteoclastic bone resorption occurs on the compression side of alveolar bone, towards which the teeth are driven. However, the molecular basis for the regulatory mechanisms underlying alveolar bone remodeling has not been sufficiently elucidated. Osteoclastogenesis is regulated by receptor activator of nuclear factor-κB ligand (RANKL), which is postulated to be expressed by the cells surrounding the tooth roots...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821339/tooth-loss-periodontal-disease-and-dental-caries-may-be-associated-with-decreased-oral-health-related-quality-of-life-but-there-is-no-evidence-about-the-magnitude-of-this-association
#11
Romina Brignardello-Petersen
No abstract text is available yet for this article.
August 11, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28820323/non-surgical-model-for-alveolar-bone-regeneration-by-bone-morphogenetic-protein-2-7-gene-therapy
#12
Mariko Kawai, Yo-Hei Kataoka, Junya Sonobe, Hiromitsu Yamamoto, Masakazu Inubushi, Takuya Ishimoto, Takayoshi Nakano, Hiroki Maruyama, Jun-Ichi Miyazaki, Toshio Yamamoto, Kazuhisa Bessho, Kiyoshi Ohura
BACKGROUND: Alveolar bone is a critical tissue for tooth retention; however, once alveolar bone is lost, it may not spontaneously regenerate. Currently, bone grafts or artificial bone are commonly used for alveolar bone regeneration therapy. However, these therapies require surgical procedures, which present risks, particularly in aged patients. Therefore, the development of alveolar bone regeneration techniques that do not require surgical procedures is critical. It is well known that stem cells present in the periosteal and periodontal ligament may be induced to differentiate into osteogenic cells...
August 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28819227/suspected-limited-mobility-of-a-middle-pleistocene-woman-from-southern-italy-strontium-isotopes-of-a-human-deciduous-tooth
#13
Federico Lugli, Anna Cipriani, Julie Arnaud, Marta Arzarello, Carlo Peretto, Stefano Benazzi
We present the Sr isotopic composition of enamel of the most ancient deciduous tooth ever discovered in Italy to assess human mobility in Middle Pleistocene. Reconstructing ancient mobility is crucial for understanding human strategy at exploiting temporally and spatially patchy resources, with most studies focusing on indirect evidences, ultimately affecting our interpretation on hominin territoriality and energetic costs invested by hominin groups. Here, we use the high spatial resolution and micro-destructivity options offered by the Laser Ablation Multi-Collector Inductively Coupled Plasma Mass Spectrometry technique, to determine the (87)Sr/ (86)Sr intra-tooth variability of a human deciduous incisor from the Middle Pleistocene layers of the Isernia La Pineta site (Italy)...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818443/types-of-external-root-resorption-of-replanted-teeth-analysis-of-the-clinical-aspects-and-of-interleukin-4-gene-polymorphisms-involvement
#14
Liliane Roskamp, Paula Cristina Trevilatto, Cleber Machado Souza, Ulisses Xavier Silva Neto, Everdan Carneiro, Luiz Fernando Fariniuk, Vânia Portela Ditzel Westphalen
INTRODUCTION: The absence or presence of root resorption on the surface of a replanted tooth indicates an immune-inflammatory reaction. Recent research even suggests the participation of host predominant immunologic profile on types of resorptions detected on the root surface. Because interleukin 4 (IL-4) is an important anti-inflammatory cytokine, this study aimed to investigate the association of clinical variables and polymorphisms in IL4 with types of resorption of replanted teeth after 1 year of follow-up...
August 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28817739/three-dimensional-volumetric-changes-in-severely-resorbed-alveolar-sockets-after-ridge-augmentation-with-bovine-derived-xenograft-and-resorbable-barrier-a-preliminary-study-on-cbct-imaging
#15
Valeria Manavella, Federica Romano, Lisa Corano, Cristina Bignardi, Mario Aimetti
PURPOSE: The primary aim of the study was to describe a novel technique to evaluate volumetric hard tissue dimensional changes after ridge augmentation procedures. The secondary aim was to apply this newly developed measuring method to compromised alveolar sockets grafted with a slowly resorbing biomaterial covered with a collagen membrane. MATERIALS AND METHODS: Eleven patients (6 men and 5 women, mean age 52.7 ± 8.3 years) requiring extraction of one hopeless tooth for severe periodontitis in the maxillary anterior area were consecutively treated with a ridge augmentation procedure...
August 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28817644/cheek-tooth-morphology-and-ancient-mitochondrial-dna-of-late-pleistocene-horses-from-the-western-interior-of-north-america-implications-for-the-taxonomy-of-north-american-late-pleistocene-equus
#16
Christina I Barrón-Ortiz, Antonia T Rodrigues, Jessica M Theodor, Brian P Kooyman, Dongya Y Yang, Camilla F Speller
Horses were a dominant component of North American Pleistocene land mammal communities and their remains are well represented in the fossil record. Despite the abundant material available for study, there is still considerable disagreement over the number of species of Equus that inhabited the different regions of the continent and on their taxonomic nomenclature. In this study, we investigated cheek tooth morphology and ancient mtDNA of late Pleistocene Equus specimens from the Western Interior of North America, with the objective of clarifying the species that lived in this region prior to the end-Pleistocene extinction...
2017: PloS One
https://www.readbyqxmd.com/read/28817143/clinical-outcomes-of-socket-preservation-using-bovine-derived-xenograft-collagen-and-collagen-membrane-post-tooth-extraction-a-6-month-randomized-controlled-clinical-trial
#17
Vincenzo Iorio-Siciliano, Andrea Blasi, Michele Nicolò, Alessandro Iorio-Siciliano, Francesco Riccitiello, Luca Ramaglia
The aim of this study was to evaluate the clinical remodeling of the alveolar socket following the application of bovine-derived xenograft collagen and collagen membrane compared to natural spontaneous healing during the first 6 months following tooth extraction. A total of 20 patients with 20 fresh alveolar sockets were randomly allocated into a test or control group. After a 6-month follow-up period, surgical reentry was performed and implants were placed. Significant statistical differences were recorded in terms of vertical and horizontal bone changes between the test and control groups...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28817142/morphologic-patterns-of-the-atrophic-posterior-maxilla-and-clinical-implications-for-bone-regenerative-therapy
#18
Alberto Monje, Istvan A Urban, Richard J Miron, Jordi Caballe-Serrano, Daniel Buser, Hom-Lay Wang
Regenerative therapies are commonly needed prior to implant placement in the posterior maxilla following tooth extraction. The aim of this study was to investigate the anatomical features of the atrophic posterior maxilla that might affect surgical approach selection and technique and risk of intra- and postoperative complications. Cone beam computed tomography files were screened to identify pristine atrophic maxillary ridges in need of bone augmentation (ridge height < 10 mm). Ridge height and width and lateral wall thickness (LWT) were measured at different levels, and palatonasal recess and lateral wall morphology were calculated...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28817133/identification-and-efficacy-ranking-of-allograft-and-xenograft-for-extraction-and-ridge-preservation-procedures
#19
Zuhair S Natto, Wael Yaghmoor, Raveendhara R Bannuru, Myron Nevins
The objective of this network meta-analysis was to identify and rank different ridge preservation procedures using allograft, xenograft, or extraction only by dimensional changes in ridge width and height after tooth extraction. Electronic and hand searches of several databases were performed in September 2016 to identify randomized controlled trials on extraction and ridge preservation with 3 to 7 months of follow-up. Eight studies were included in the network meta-analysis. The total number of teeth included in these trials was 466, which were randomly assigned to treatment groups...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28817127/ten-year-nonsurgical-periodontal-treatment-protocol-with-adjunctive-use-of-diode-laser-monitoring-clinical-outcomes-in-%C3%A2-6-mm-pockets-a-retrospective-controlled-case-series
#20
Marisa Roncati, Annalisa Roncati, Cinzia Barbieri, Paolo Vescovi
The clinical effects of treatment with 808- and 980-nm diode lasers as an adjunct to a uniform and consistent nonsurgical periodontal treatment protocol (NSPTP) for initial probing pockets ≥ 6 mm with a 10-year follow-up were evaluated. In total, 24 patients (16 test cases and 8 control cases) were treated with the NSPTP. The control group (CG) was treated only with nonsurgical conventional therapy, while the test group (TG) received treatment with thermal diode lasers (wavelength of 808 or 980 nm). All patients had recall visits every 3 months and were reevaluated at 1 year after NSPTP...
September 2017: International Journal of Periodontics & Restorative Dentistry
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