Fanyi Guo, Jianfeng Li, Ziyu Chen, Tianxiao Wang, Ruyu Wang, Tianyao Wang, Yifeng Bian, Yifei Du, Hua Yuan, Yongchu Pan, Jianliang Jin, Huijun Jiang, Feng Han, Jiandong Jiang, Fan Wu, Yuli Wang
The excess production of reactive oxygen species (ROS) will delay tooth extraction socket (TES) healing. In this study, we developed an injectable thermosensitive hydrogel (NBP@BP@CS) used to treat TES healing. The hydrogel formulation incorporated black phosphorus (BP) nanoflakes, recognized for their accelerated alveolar bone regeneration and ROS-scavenging properties, and dl-3- n -butylphthalide (NBP), a vasodilator aimed at enhancing angiogenesis. In vivo investigations strongly demonstrated that NBP@BP@CS improved TES healing due to antioxidation and promotion of alveolar bone regeneration by BP nanoflakes...
May 10, 2024: ACS Applied Materials & Interfaces