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https://www.readbyqxmd.com/read/29224185/tension-force-induced-bone-formation-in-orthodontic-tooth-movement-via-modulation-of-the-gsk-3%C3%AE-%C3%AE-catenin-signaling-pathway
#1
Yelin Mao, Liangliang Wang, Ye Zhu, Yu Liu, Hongwei Dai, Jianping Zhou, Dechun Geng, Lin Wang, Yong Ji
Orthodontic force-induced osteogenic differentiation and bone formation at tension sites play a critical role in orthodontic tooth movement. However, the molecular mechanism underlying this phenomenon is poorly understood. In the current study, we investigated the involvement of the GSK-3β/β-catenin signaling pathway, which is critical for bone formation during tooth movement. We established a rat tooth movement model to test the hypothesis that orthodontic force may stimulate bone formation at the tension site of the moved tooth and promote the rate of tooth movement via regulation of the GSK-3β/β-catenin signaling pathway...
December 9, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29224060/differences-between-osteoradionecrosis-and-medication-related-osteonecrosis-of-the-jaw
#2
Masaya Akashi, Satoshi Wanifuchi, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Shungo Furudoi, Takahide Komori
PURPOSE: The appearance of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) is similar, but clinically important differences between ORN and MRONJ exist. The aim of this study was to compare the clinical data between ORN and MRONJ and to reveal the critical differences between these diseases. METHODS: We retrospectively reviewed the epidemiological data, clinical findings, and treatment in 27 ORN and 61 MRONJ patients. Radiographic signs before the initiation of treatment were also assessed...
December 9, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29223639/extensive-phenotyping-of-the-orofacial-and-dental-complex-in-crouzon-syndrome
#3
Alexander Khominsky, Robin Yong, Sarbin Ranjitkar, Grant Townsend, Peter J Anderson
OBJECTIVES: Fibroblast growth factor receptor 2 (FGFR2) C342Y/+ mutation is a known cause of Crouzon syndrome that is characterised by craniosynostosis and midfacial hypoplasia. Our aim was to conduct extensive phenotyping of the maxillary, mandibular and dental morphology associated with this mutation. MATERIALS AND METHODS: Morphometric data were obtained from 40 mice, representing two genotypes (Crouzon and wild-type) and two sexes (males and females) (n=10 in each group)...
October 27, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29223396/accelerated-dentinogenesis-by-inhibiting-the-mitochondrial-fission-factor-dynamin-related-protein-1
#4
Yumiko Matsuishi, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Yuta Hirofuji, Hiroshi Sato, Hiroko Wada, Tamotsu Kiyoshima, Kazuaki Nonaka
Undifferentiated odontogenic epithelium and dental papilla cells differentiate into ameloblasts and odontoblasts, respectively, both of which are essential for tooth development. These differentiation processes involve dramatic functional and morphological changes of the cells. For these changes to occur, activation of mitochondrial functions, including ATP production, is extremely important. In addition, these changes are closely related to mitochondrial fission and fusion, known as mitochondrial dynamics...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29222672/morphological-alterations-in-the-position-of-the-mandibular-foramen-in-dentate-and-edentate-mandibles
#5
Niki Matveeva, Lidija Popovska, Biljana Evrosimovska, Elizabeta Chadikovska, Julijana Nikolovska
The technique of inferior alveolar nerve (IAN) block must be based on precise anatomical knowledge regarding the correct position of the mandibular foramen (MF). The aim of the investigation reported here was to determine the anatomic and topographic localization of the MF according to mandibular ramus anatomic landmarks and to identify morphological alterations in the position of the MF and size and shape of the ramus in terms of the impact of tooth socket loss in the molar and premolar region. Seventy-three dry human adult mandibles were divided into two groups according to dental status...
December 8, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/29222227/pings-phone-based-intervention-under-nurse-guidance-after-stroke-interim-results-of-a-pilot-randomized-controlled-trial
#6
Fred Sarfo, Frank Treiber, Mulugeta Gebregziabher, Sheila Adamu, Sachin Patel, Michelle Nichols, Dominic Awuah, Asumadu Sakyi, Nyantakyi Adu-Darko, Arti Singh, Raelle Tagge, Jenkins Carolyn, Bruce Ovbiagele
BACKGROUND AND PURPOSE: Stroke exacts an immense toll in sub-Saharan Africa where there are few resources, and stroke prevention research is limited. The aim of this study is to test the feasibility and preliminary efficacy of an m-Health technology-enabled, nurse-guided intervention in improving blood pressure (BP) control among Ghanaian stroke patients within 1 month of symptom onset. METHODS: We conducted a 2-arm cluster pilot randomized controlled trial involving 60 recent stroke survivors encountered within a single tertiary medical system in Ghana...
December 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29220087/dual-energy-based-metal-segmentation-for-metal-artifact-reduction-in-dental-computed-tomography
#7
Mohamed A A Hegazy, Mohamed Elsayed Eldib, Daniel Hernandez, Myung Hye Cho, Min Hyoung Cho, Soo Yeol Lee
PURPOSE: In a dental CT scan, the presence of dental fillings or dental implants generates severe metal artifacts that often compromise readability of the CT images. Many metal artifact reduction (MAR) techniques have been introduced, but dental CT scans still suffer from severe metal artifacts particularly when multiple dental fillings or implants exist around the region of interest. The high attenuation coefficient of teeth often causes erroneous metal segmentation, compromising the MAR performance...
December 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/29219193/the-effect-of-horizontal-and-vertical-furcation-involvement-on-molar-survival-a-retrospective-study
#8
L Nibali, C Sun, A Akcalı, Y C Yeh, Y K Tu, N Donos
BACKGROUND: Periodontal involvement of the furcation area (furcation involvement, FI) has been reported to confer to molars a higher risk of tooth loss. AIMS: The aim of this retrospective analysis was to assess the effect of FI on disease progression and tooth loss in molars of patients with chronic periodontitis undergoing supportive periodontal therapy (SPT) in a UK private practice setting. MATERIALS AND METHODS: Six-hundred and thirty-three molars were analysed in 100 chronic periodontitis patients treated with active periodontal therapy (APT) and followed up in SPT for at least 5 years...
December 8, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29217962/spectrophotometric-evaluation-of-crown-fragment-a-year-after-reattachment-using-fiber-reinforced-post-a-case-report
#9
Fundaoğlu Funda Küçükekencı, Ahmet Serkan Küçükekencı
Background: Crown fracture is the most common type of fracture and frequently affects the anterior teeth. Crown fractures have been treated in several ways depending on the location and kind of fracture. This case emphasizes reattachment of fractured fragments using fiber-reinforced post. Also this case report underlines the related aesthetic concerns of reattaching of the fractured fragment. Case Report: Intraorally, examination revealed a complicated crown-root fracture of the left maxillary central (#21) and lateral incisor (#22)...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217358/lack-of-agreement-between-objective-and-subjective-measures-in-the-evaluation-of-masticatory-function-a-preliminary-study
#10
Aline Pedroni-Pereira, Maria Carolina Salomé Marquezin, Darlle Santos Araujo, Luciano José Pereira, Silvana Bommarito, Paula Midori Castelo
The evaluation of mastication is important to understand the masticatory behavior and diagnose feeding difficulties. The objective of this preliminary study was to verify if there is agreement between objective and subjective validated methods of chewing evaluation in a convenience sample which consisted of 32 adolescents (mean 15.5years), complete permanent dentition and free of tooth decay. The Quality of Masticatory Function Questionnaire with the Food-Mastication, Habits, Meat, Fruit and Vegetables domains was used in the subjective evaluation...
December 4, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29216779/the-plaque-and-gingivitis-inhibiting-capacity-of-a-commercially-available-mouthwash-containing-essential-oils-and-ethyl-lauroyl-arginate-a-randomized-clinical-trial
#11
Liv O Valør, Inghild K R Norton, Odd C Koldsland, Anne Merete Aass, Andrej M Grjibovski, Hans R Preus
OBJECTIVE: A commercially available mouth rinse with ethyl lauroyl arginate and essential oils claims to have better antimicrobial properties than the traditional essential oil products. The aim of this study was to compare the plaque and gingivitis inhibiting effect of the commercial product containing essential oils with ethyl lauroyl arginate with one placebo and one negative control in a modified experimental gingivitis model. MATERIALS AND METHODS: In three groups of healthy volunteers, experimental gingivitis was induced and monitored over 21 d, simultaneously treated with the commercial test solution, 21...
December 7, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29216024/maxillary-cortical-bone-thickness-in-a-south-eastern-anatolian-population-a-cone-beam-computed-tomography-study
#12
Ozkan Adiguzel, Ceren Aktuna Belgin, Seda Falakaloglu, Suzan Cangul, Zeki Akkus
BACKGROUND The aim of this study was to measure the distance between the maxillary premolar and molar teeth apices to the buccal cortical bone and evaluate differences in gender and age group, using cone beam computed tomography (CBCT). MATERIAL AND METHODS This retrospective study comprised of 451 premolar and molar teeth of one hundred and thirteen patients who were admitted to Dicle University, Faculty of Dentistry, Department of Dentomaxillofacial Radiology for different reasons. Data were analyzed using Student's t-tests and Tukey HSD tests...
December 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29215720/gsk3%C3%AE-regulates-ameloblast-differentiation-via-wnt-and-tgf-%C3%AE-pathways
#13
Yaling Yang, Ziyue Li, Guoqing Chen, Jie Li, Hui Li, Mei Yu, Weiping Zhang, Weihua Guo, Weidong Tian
Wnt and TGF-β signaling pathways participate in regulating a variety of cell fates during organogenesis, including tooth development. Despite well-documented, the specific mechanisms, especially how these two pathways act coordinately in regulating enamel development, remain unknown. In this study, we identified Glycogen Synthase Kinase 3 beta (GSK3β), a negative regulator of Wnt signal pathway, participated in ameloblast differentiation via Wnt and TGF-β pathways during enamel development. In vitro rat mandible culture treated with specific GSK3β inhibitor SB415286 displayed enamel defects, accompanied by disrupted ameloblasts polarization, while odontoblasts and dentin appeared to be unaffected...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215687/impact-of-microabrasion-on-the-effectiveness-of-tooth-bleaching
#14
Camila Evelyn Perete-de-Freitas, Paula Damasceno Silva, André Luis Faria-E-Silva
The aim of the present study was to evaluate the effect of prior microabrasion on the teeth color change and tooth bleaching effectiveness. Eight sound molars were mesio-distally sectioned and the halves were randomly allocated to receive enamel microabrasion or non-abrasion (control) in one of surfaces (buccal or lingual), while the remaining surface received the other treatment. The tooth color on baseline was evaluated by spectrophotometer (CieL*a*b system). After the microabrasion procedure, the tooth color was measured again...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29215686/are-desensitizing-toothpastes-equally-biocompatible-and-effective-against-microorganisms
#15
Samira Esteves Afonso Camargo, Noala Vicensoto Moreira Milhan, Fernanda de Oliveira Saraiva, Jonatas Rafael de Oliveira, Luciane Dias de Oliveira, Carlos Henrique Ribeiro Camargo
The aims of this study were evaluate cytotoxicity, genotoxicity, antimicrobial activity of desensitizing toothpastes compared to a common one and the surface roughness of tooth enamel submitted to brushing with these toothpastes. Samples of three desensitizing toothpastes (Colgate Sensitive, Sensodyne and Oral B Sensitive) and common toothpaste (Colgate) were placed in contact with gingival human fibroblasts. Cytotoxicity and genotoxocity were measured by MTT assay and micronucleus test. Antimicrobial activity of the toothpastes extracts against C...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29215370/opioid-use-after-discharge-in-postoperative-patients-a-systematic-review
#16
Adina E Feinberg, Tyler R Chesney, Sanjho Srikandarajah, Sergio A Acuna, Robin S McLeod
BACKGROUND: Over the past 2 decades, there has been an increase in opioid use and subsequently, opioid deaths. The amount of opioid prescribed to surgical patients has also increased. The aim of this systematic review was to determine postdischarge opioid consumption in surgical patients compared with the amount of opioid prescribed. Secondary outcomes included adequacy of pain control and disposal methods for unused opioids. OBJECTIVE: The objective of this study is to characterize postdischarge opioid consumption and prescription patterns in surgical patients...
December 5, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29215321/mesenchymal-endometrial-stem-stromal-cells-for-hard-tissue-engineering-a-review-of-in-vitro-and-in-vivo-evidence
#17
Fahimeh S Tabatabaei, Jafar Ai
Hard tissues including teeth, bone and cartilage have inability or poor capacity to self-renew, especially in large defects. Therefore, repair of damages in these tissues represents a huge challenge in the medical field today. Hard tissue engineering commonly utilizes different stem cell sources as a promising strategy for treating bone, cartilages and tooth defects or disorders. Decades ago, researchers successfully isolated and identified endometrial mesenchymal stem/stromal cells (EnSCs) and discovered their multidifferentiation potential...
December 7, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29215300/dental-anomalies-in-different-growth-and-skeletal-malocclusion-patterns
#18
Clarissa Christina Avelar Fernandez, Christiane Vasconcellos Cruz Alves Pereira, Ronir Raggio Luiz, Alexandre Rezende Vieira, Marcelo De Castro Costa
OBJECTIVES: To evaluate prevalence, distribution, and sexual dimorphism of dental anomalies (DA) among different skeletal malocclusions (SM) and growth patterns (GP) under the hypothesis that specific clinical patterns exist and may indicate common etiological roots. MATERIALS AND METHODS: A total of 1047 orthodontic records of patients older than 8 years were evaluated. The SN-GoGn angle was used to classify GP (hypodivergent, normal, and hyperdivergent), and the ANB angle was used to verify SM (Angle Classes I, II, and III)...
December 7, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/29215153/the-role-of-municipal-public-policies-in-oral-health-socioeconomic-inequalities-in-brazil-a-multilevel-study
#19
Violeta Rodrigues Aguiar, Marcos Pascoal Pattussi, Roger Keller Celeste
OBJECTIVES: It is known that fluoridation has a contextual effect on oral health socioeconomic inequalities, but broad public policies have not been investigated. Thus, the aim of this study was to determine the effects of municipal public policies on oral health across different social strata. METHODS: This was a cross-sectional study with 7328 12-year-old children and 5445 15-19-year-old adolescents from 177 Brazilian municipalities. Information at municipal level was collated for dental services, educational services, sanitation and water fluoridation...
December 7, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29215088/charcot-marie-tooth-disease-type-2a-with-an-autosomal-recessive-inheritance-the-first-report-of-an-adult-onset-disease
#20
Ryota Hikiami, Hirofumi Yamashita, Natsuko Koita, Naoto Jingami, Nobukatsu Sawamoto, Kaoru Furukawa, Hiromichi Kawai, Tomoya Terashima, Nobuyuki Oka, Akihiro Hashiguchi, Hiroshi Takashima, Makoto Urushitani, Ryosuke Takahashi
Axonal Charcot-Marie-Tooth disease (CMT) is most frequently caused by mutations in the MFN2 gene (CMT2A) that can lead to various clinical phenotypes. The age at disease onset varies, but most cases occur before adolescence. We report two Japanese sisters who presented with middle-age-onset peripheral neuropathy with distinct clinical features. In the affected sisters, a homozygous missense mutation, c.1894C>T, p.R632W, corresponding to the transmembrane domain of MFN2 was identified; this mutation was heterozygous in another non-affected sibling, demonstrating co-segregation of the genotype and phenotype...
November 13, 2017: Journal of Human Genetics
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