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Weijie Gu, Beihe Wang, Fangning Wan, Junlong Wu, Xiaolin Lu, Hongkai Wang, Yao Zhu, Hailiang Zhang, Guohai Shi, Bo Dai, Dingwei Ye
Sex-determining region Y-box protein (SOX) genes serve an important role in cancer growth and metastasis. The present study aimed to determine the predictive ability of SOX and associated genes identified through molecular network in clear cell renal cell carcinoma (RCC). A total of 505 patients with clear cell RCC from The Cancer Genome Atlas (TCGA) cohorts were collected in this study. The expression profile of SOX and associated genes were obtained from the TCGA RNAseq database. Clinicopathological characteristics, including age, gender, tumor grade, stage, laterality disease-free-survival and overall survival (OS) were collected...
April 2018: Oncology Letters
Ryuji Yamamoto, Tsuyoshi Osawa, Yusuke Sasaki, Shogo Yamamoto, Motonobu Anai, Kouji Izumi, Yoshihiro Matsumura, Juro Sakai, Hiroyuki Aburatani, Atsushi Mizokami, Tatsuhiko Kodama, Toshiya Tanaka
The non-POU domain-containing octamer binding protein p54nrb /NONO is a multifunctional nuclear protein involved in RNA splicing, processing, and transcriptional regulation of nuclear hormone receptors. Through chromosome copy number analysis via whole-exome sequencing, we revealed amplification of the chromosome Xq11.22-q21.33 locus containing the androgen receptor ( AR ) and NONO genes in androgen-independent, castration-resistant prostate cancer (CRPC)-like LNCaP-SF cells. Moreover, NONO was frequently amplified and overexpressed in patients with CRPC...
February 13, 2018: Oncotarget
Jie Huang, G Patricia Casas Garcia, Matthew A Perugini, Archa Fox, Charles Bond, Mihwa Lee
Members of the Drosophila Behavior Human Splicing (DBHS) protein family are nuclear proteins implicated in many layers of nuclear functions, including RNA biogenesis as well as DNA repair. Definitive of the DBHS protein family, the conserved DBHS domain provides a dimerization platform that is critical for the structural integrity and function of these proteins. The three human DBHS proteins - splicing factor proline- and glutamine-rich (SFPQ), paraspeckle component 1 (PSPC1), and non-POU domain-containing octamer binding protein (NONO) - form either homo- or heterodimers; however, the relative affinity and mechanistic details of preferential heterodimerization are yet to be deciphered...
March 12, 2018: Journal of Biological Chemistry
Amer Jamalpoor, Rolf W Sparidans, Carla Pou Casellas, Johannes J M Rood, Mansi Joshi, Rosalinde Masereeuw, Manoe J Janssen
Nephropathic cystinosis is characterized by abnormal intralysosomal accumulation of cystine throughout the body causing irreversible damage to various organs, particularly the kidneys. Cysteamine, the currently available treatment, can reduce lysosomal cystine and postpone disease progression. However, cysteamine poses serious side effects and does not address all symptoms of cystinosis. To screen for new treatment options, a rapid and reliable high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed to quantify cystine in conditionally immortalized human proximal tubular epithelial cells (ciPTEC)...
March 8, 2018: Biomedical Chromatography: BMC
Tinchou Li, Mingcheng Lee, Fuming Tsai, Yunhsiang Chen, Yiyin Lin, Maoliang Chen
BACKGROUND: Based on accumulating evidence, the regulation of protein expression by antipsychotic drugs (APDs) might be closely related to the control of psychotic symptoms when these drugs are used to treat mental disorders. The low quantity of nuclear proteins in the cell hinders their detection because signal for rare proteins are masked in most proteomic detection systems. METHODS: Nuclear proteins fractionated from APD-treated B35 cells were labeled with iTRAQ and detected by LC/MS/MS to investigate APD-induced alterations in nuclear protein expression...
March 7, 2018: BMC Pharmacology & Toxicology
Alberto Goday, Olga Castañer, David Benaiges, Anna Busquets Pou, José M Ramón, Maria Del Mar Iglesias, Luis Barranco Priego, Juana A Flores Le-Roux
BACKGROUND: Helicobacter pylori (HP) colonization is common in severely obese patients undergoing bariatric surgery. HP eradication treatment could influence the evolution of weight loss and metabolic markers after bariatric surgery. OBJECTIVE: To assess the influence of HP eradication in the clinical course of morbid obesity patients treated with bariatric surgery (gastric bypass (LRYGB) and sleeve gastrectomy (LSG)) METHODS: Retrospective analysis of a prospective cohort of 229 patients that underwent bariatric surgery between 2010 and 2013 in Hospital del Mar...
March 2, 2018: Obesity Surgery
Bo G Lindberg, Xiongzhuo Tang, Widad Dantoft, Priya Gohel, Shiva Seyedoleslami Esfahani, Jessica M Lindvall, Ylva Engström
Gut immunity is regulated by intricate and dynamic mechanisms to ensure homeostasis despite a constantly changing microbial environment. Several regulatory factors have been described to participate in feedback responses to prevent aberrant immune activity. Little is, however, known about how transcriptional programs are directly tuned to efficiently adapt host gut tissues to the current microbiome. Here we show that the POU/Oct gene nubbin (nub) encodes two transcription factor isoforms, Nub-PB and Nub-PD, which antagonistically regulate immune gene expression in Drosophila...
March 2, 2018: PLoS Pathogens
Tomoko Kato, Daisuke Tanaka, Seiji Muro, Byambatseren Jambaljav, Eisaku Mori, Shin Yonemitsu, Shogo Oki, Nobuya Inagaki
Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of early onset diabetes. The hepatocyte nuclear factor-1-beta (HNF1B) gene is responsible for MODY type 5 (MODY5) with distinctive clinical features, including pancreatic atrophy and renal disease. We herein report a Japanese case of young-onset diabetes with typical phenotypes of MODY5 and a novel heterozygous missense mutation (p.L145Q) in the HNF1B gene. The mutation was located in the POU-specific domain, and the amino acid residue L145 was highly conserved among species...
February 28, 2018: Internal Medicine
Norikatsu Miyoshi, Shiki Fujino, Masayuki Ohue, Masayoshi Yasui, Yusuke Takahashi, Keijiro Sugimura, Akira Tomokuni, Hirofumi Akita, Shogo Kobayashi, Hidenori Takahashi, Takeshi Omori, Hiroshi Miyata, Masahiko Yano
PURPOSE: The POU5F1 gene, which encodes the POU domain, class 5, transcription factor 1 (also known as Oct-4), is expressed in embryonic stem cells where it regulates pluripotency and proliferation. Few studies have examined the expression and significance of POU5F1 in cancer tissues. The aim of this study was to clarify its significance in colorectal cancer (CRC). METHODS: The study included 95 patients who underwent surgery for CRC from 2009 to 2011. The correlations between the POU5F1 gene expression and the clinical parameters were assessed in these patients...
February 27, 2018: Surgery Today
Carl Cummings, Jane C Finlay, Noni E MacDonald
Les infestations par les poux de tête ( Pediculus humanus capitis ) ne constituent ni un risque sanitaire primaire ni un vecteur de maladie, mais représentent plutôt un problème de société au coût impor- tant. Pour diagnostiquer une infestation, il faut déceler un pou vivant. Même si les pyréthines et la perméthrine demeurent les traitements de première intention au Canada, la solution de myristate d'isopropyle et de ST-cyclométhicone et la diméticone peuvent être envisagées en deuxième intention après un échec thérapeutique démontré...
February 2018: Paediatrics & Child Health
Joan M Raurich, Juan A Llompart-Pou, Mariana A Novo, Cristina Talavera, Mireia Ferreruela, Ignacio Ayestarán
PURPOSE: To identify risk factors of successful continuous renal replacement therapy (CRRT) weaning and to evaluate the effect of furosemide in the recovery of urine output after CRRT stop. MATERIALS AND METHODS: Retrospective, observational study of critical patients treated with CRRT. Weaning tests (WT) were classified in two groups: successful (urine output was recovered and CRRT was not required again) and failed (CRRT was required again). A multiple logistic regression model was used to identify risk factors of successful CRRT WT...
February 16, 2018: Journal of Critical Care
Hsin-Pou Huang, Minchen Wei, Li-Chen Ou
In comparison to the great efforts made on the enhancement of image quality for tablet displays, little attention has been paid on the concept of white point. Given the increasing popularity of the light sources with chromaticities off the Planckian locus and color-tunable LED lighting, it is important to investigate human's white perception of tablet display under different ambient lighting conditions. This study investigated the white appearance of a tablet display under 17 ambient lighting conditions, including a dark condition, seven conditions with chromaticities on the Planckian locus, and nine conditions with chromaticities off the Planckian locus, (i...
February 19, 2018: Optics Express
V S Tompkins, D P Valverde, W N Moss
OBJECTIVE: The function of Epstein-Barr virus (EBV) stable intronic sequence (sis)RNAs, non-coding RNAs transcribed from a region required for EBV-mediated cellular transformation, remain unknown. To better understand the function of ebv-sisRNA-1 and ebv-sisRNA-2 from the internal repeat (IR)1 region of EBV, we used a combination of bioinformatics and biochemistry to identify associated RNA binding proteins. The findings reported here are part of ongoing studies to determine the functions of non-coding RNAs from the IR1 region of EBV...
February 20, 2018: BMC Research Notes
María Carmen Fernández-Moreno, Elena Martí-Cuñat, Guillermo Pou, Joaquín Ortega
BACKGROUND: Spigelian hernia (SH) is a rare entity, but its surgical treatment is essential because of its high complication risk. Laparoscopic approaches have become the option in elective surgery because it has less morbidity and requires a shorter stay. Several laparoscopic techniques have been employed, but there is no gold standard technique for this kind of hernia. We report, in this study, our experience with intraperitoneal onlay mesh (IPOM) repair. MATERIALS AND METHODS: Fifteen patients underwent elective surgery for SH between 2008 and 2015 in a Short-Stay Surgical Unit...
February 16, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Zhao-Yan Yu, Zi Wang, Ke-Yue Lee, Ping Yuan, Jie Ding
The role of long non-coding RNAs (lncRNAs) in the carcinogenesis and progression of tumors has been receiving increasing attention. Colon cancer-associated transcript 2 (CCAT2), a type of oncogenic lncRNA, is regarded as a novel biomarker of poor prognosis and metastasis in various types of cancer. However, the molecular contributions of CCAT2 to gastric cancer (GC) progression remain largely unclear. The aim of the present study was to demonstrate the effect of silencing CCAT2 on the biological behavior of GC BGC-823 cells and illustrate the potential underlying molecular mechanisms...
March 2018: Oncology Letters
Zhongyang Xu, Xiuyu Wang, Yanping Zheng
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis and autoimmune disease, the etiology and pathogenesis of which remain largely unknown. In the present study, blood samples were harvested from patients with AS and from healthy volunteers as a normal control (NC) for RNA-sequencing. Differentially expressed genes (DEGs) in the AS group compared with the NC group were identified, and gene ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were subsequently performed...
February 2018: Experimental and Therapeutic Medicine
Yin-Ju Chen, Chia-Chun Kuo, Lai-Lei Ting, Long-Sheng Lu, Ya-Ching Lu, Ann-Joy Cheng, Yun-Tien Lin, Chien-Ho Chen, Jo-Ting Tsai, Jeng-Fong Chiou
Piperlongumine (PL), a natural product of Piper longum, inhibits multiple malignant phenotypes. Therefore, the present study examined whether PL suppresses cancer stemness in oral cancer. The cellular effects of PL were determined by examining alterations in tumor sphere formation, cell migration, invasion, proliferation ability, chemosensitivity and radiosensitivity. Reverse transcription-quantitative polymerase chain reaction analysis and western blotting were performed in order to determine molecular expression levels...
February 2018: Oncology Letters
Sheng-Xia Zheng, Jian Wang, Xue-Li Wang, Asim Ali, Li-Min Wu, Yu-Sheng Liu
Intrauterine adhesions (IUA) are associated with the loss of stem cells in the endometrium. Menstrual blood‑derived stem cells (MenSCs) can be isolated from the menstrual blood and differentiated into endometrial cells. To check the transplantation feasibility of MenSCs for the treatment of severe IUA, MenSCs were isolated from menstrual blood, cultured in Dulbecco's modified Eagle's medium (DMEM), identified by immunocytochemistry and flow cytometry, differentiated into endometrial cells in vitro, and finally transplanted into the axillary subcutaneous tissue of non‑obese diabetic/severe combined immunodeficiency (NOD‑SCID) mice to create endometrial tissue...
April 2018: International Journal of Molecular Medicine
Kumiko Oguma, Kaori Kanazawa, Ikuro Kasuga, Satoshi Takizawa
Ultraviolet light emitting diodes (UV-LEDs) are small mercury-free devices that can be installed at the point of use (POU) of water for disinfection. Considering that heterotrophic bacteria are of concern in drinking water systems, we applied a flow-through UV-LED apparatus to dechlorinated tap water, and determined the heterotrophic plate count (HPC) in samples after UV-LED exposure (UV+) compared to samples without UV-LED application (UV-). The UV+ and UV- samples were maintained at 20 °C to track HPC profiles during storage for seven days...
February 2, 2018: Photochemistry and Photobiology
Huakang Tu, Chi Pang Wen, Shan Pou Tsai, Wong-Ho Chow, Christopher Wen, Yuanqing Ye, Hua Zhao, Min Kuang Tsai, Maosheng Huang, Colin P Dinney, Chwen Keng Tsao, Xifeng Wu
OBJECTIVES: To assess the independent and joint associations of major chronic diseases and disease markers with cancer risk and to explore the benefit of physical activity in reducing the cancer risk associated with chronic diseases and disease markers. DESIGN: Prospective cohort study. SETTING: Standard medical screening program in Taiwan. PARTICIPANTS: 405 878 participants, for whom cardiovascular disease markers (blood pressure, total cholesterol, and heart rate), diabetes, chronic kidney disease markers (proteinuria and glomerular filtration rate), pulmonary disease, and gouty arthritis marker (uric acid) were measured or diagnosed according to standard methods, were followed for an average of 8...
January 31, 2018: BMJ: British Medical Journal
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