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https://www.readbyqxmd.com/read/28638297/pediatric-nasal-tip-amputation-successfully-treated-with-nonmicrovascular-replantation-and-hyperbaric-oxygen-therapy
#1
Jason D Pou, H Devon Graham
BACKGROUND: Nasal tip amputation is a rare but difficult problem to manage. Nonmicrovascular nasal tip replantation is a valid and relatively simple repair option for moderate nasal defects, but tissue ischemia and graft failure occur frequently. CASE REPORT: We present the case of a pediatric nasal tip amputation from a dog bite treated with replantation within 5 hours. The 2.5-cm avulsed tip contained skin, cartilage, and mucosa and was replanted as a 3-layer composite graft...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28633916/novel-variant-of-oct4b4-is-differentially-expressed-in-human-embryonic-stem-and-embryonic-carcinoma-cells
#2
Ensieh M Poursani, Majid Mehravar, Bahram Mohammad Soltani, Seyed Javad Mowla
POU domain proteins are an important family of transcription factors that regulates cell type-specific gene expression. One of the most crucial members of this family that maintains pluripotency and self-renewal of embryonic stem cells is POU5F1/OCT4. The OCT4 gene can generate several variants under different situations/cell types includes OCT4A that is the major factor sustains pluripotency in embryonic stem and embryonic carcinoma cells, and also OCT4B and OCT4B1, which might be transcribed from a different potential promoter located in intron1 and are expressed in various tissues and cell types...
June 17, 2017: Gene
https://www.readbyqxmd.com/read/28621470/the-pou-homeodomain-transcription-factor-poum2-and-broad-complex-isoform-2-transcription-factor-induced-by-20-hydroxyecdysone-collaboratively-regulate-vitellogenin-gene-expression-and-egg-formation-in-the-silkworm-bombyx-mori
#3
Y Lin, H Liu, C Yang, J Gu, G Shen, H Zhang, E Chen, C Han, Y Zhang, Y Xu, J Wu, Q Xia
Vitellogenin (Vg) is a source of nutrition for embryo development. Our previous study showed that the silkworm (Bombyx mori) transcription factor broad complex isoform 2 (BmBrC-Z2) regulates gene expression of the Vg gene (BmVg) by induction with 20-hydroxyecdysone (20E). However, the mechanism by which 20E regulates BmVg expression was not clarified. In this study, cell transfection experiments showed that the BmVg promoter containing the POU homeodomain transcription factor POUM2 (POUM2) and BrC-Z2 cis-response elements (CREs) showed a more significant response to 20E than that harbouring only the BrC-Z2 or POUM2 CRE...
June 16, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28600144/targeting-proteins-to-rna-transcription-and-processing-sites-within-the-nucleus
#4
Noemí Sánchez-Hernández, Silvia Prieto-Sánchez, Cristina Moreno-Castro, Juan Pablo Muñoz-Cobo, Younes El Yousfi, Sofía Boyero-Corral, Marc Suñé-Pou, Cristina Hernández-Munain, Carlos Suñé
Studies of the spatial organization of the highly compartmentalized eukaryotic nucleus and dynamics of transcription and RNA processing within it are fundamental for fully understanding how gene expression is regulated in the cell. Although some progress has been made in deciphering the functional consequences of this complex network of interacting molecules in the context of nuclear organization, how proteins and RNA move in the nucleus and how the transcription and RNA processing machineries find their targets are important questions that remain largely unexplored...
June 6, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28586020/altered-expression-of-epithelial-mesenchymal-transition-and-pluripotent-associated-markers-by-sex-steroid-hormones-in-human-embryonic-stem-cells
#5
So-Ye Jeon, Kyung-A Hwang, Cho-Won Kim, Eui-Bae Jeung, Kyung-Chul Choi
Embryonic stem (ES) cells are pluripotent stem cells derived from a developmental stage of pre‑implanted embryos. The present study investigated the effect of female sex steroid hormones on the characteristics of human ES cells by using a feeder‑free culture protocol. In a feeder‑free condition without sex hormones, human ES cells assumed the form of tightly packed cells that grow in a monolayer. The cells had clean and defined edges with no evidence of differentiation and expressed several markers specific for undifferentiated ES cells including POU class 5 homeobox 1 (POU5F1), sex determining region Y‑box 2 (SOX2) and NANOG homeobox (NANOG)...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28577854/diabetes-with-early-kidney-involvement-may-shorten-life-expectancy-by-16-years
#6
Chi Pang Wen, Chia Hsuin Chang, Min Kuang Tsai, June Han Lee, Po Jung Lu, Shan Pou Tsai, Christopher Wen, Chien Hua Chen, Chih Wen Kao, Chwen Keng Tsao, Xifeng Wu
This study aimed to identify the excess risks associated with diabetic patients with early kidney involvement (early diabetic kidney disease). The mortality risks of early diabetic kidney disease, defined as diabetes in early stages 1-3 chronic kidney disease (CKD), were assessed from a cohort of 512,700 adults in Taiwan participating in a health surveillance program from 1994-2008. Three related groups were identified and compared: diabetes without CKD, early diabetic kidney disease, and early CKD without diabetes...
June 1, 2017: Kidney International
https://www.readbyqxmd.com/read/28557428/oxime-based-and-catalyst-free-dynamic-covalent-polyurethanes
#7
Wen-Xing Liu, Chi Zhang, Huan Zhang, Ning Zhao, Zhi-Xiang Yu, Jian Xu
Polyurethanes (PUs) have many applications resulting from their preeminent properties, but being commonly used toxic catalysts, and the lack of processability for PU thermosets cause limitations. Herein, we report a new class of the PU-like dynamic covalent polymers, poly(oxime-urethanes) (POUs), which are prepared from the uncatalyzed polyaddition of multifunctional oximes and hexamethylene diisocyanate (HDI) at ambient temperature. Kinetics studies reveal that almost complete polymerization (∼99% conversion) can be achieved in 3 h at 30 °C in dichloromethane (DCM), the most effective among the solvents evaluated, producing linear POUs with comparable molecular weights to the catalyzed PUs...
June 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28529911/severe-trauma-in-the-geriatric-population
#8
REVIEW
Juan Antonio Llompart-Pou, Jon Pérez-Bárcena, Mario Chico-Fernández, Marcelino Sánchez-Casado, Joan Maria Raurich
Geriatric trauma constitutes an increasingly recognized problem. Aging results in a progressive decline in cellular function which leads to a loose of their capacity to respond to injury. Some medications commonly used in this population can mask or blunt the response to injury. Falls constitute the most common cause of trauma and the leading cause of trauma-related deaths in this population. Falls are complicated by the widespread use of antiplatelets and anticoagulants, especially in patients with brain injury...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28500132/the-zinc-finger-e-box-binding-homeobox-1-zeb1-promotes-the-conversion-of-mouse-fibroblasts-into-functional-neurons
#9
Long Yan, Yue Li, Zixiao Shi, Xiaoyin Lu, Jiao Ma, Baoyang Hu, Jianwei Jiao, Hongmei Wang
The zinc finger E-box binding transcription factor Zeb1 plays a pivotal role in the epithelial-mesenchymal transition (EMT). Numerous studies have focused on the molecular mechanisms by which Zeb1 contributes to this process. However, the functions of Zeb1 beyond EMT remain largely elusive. Using a transdifferentiation system to convert mouse embryonic fibroblasts (MEFs) into functional neurons via the neuronal transcription factors Achaete-scute family bHLH transcription factor1 (Ascl1), POU class 3 homeobox 2 (POU3F2/Brn2) and Neurogenin 2 (Neurog2, Ngn2) (ABN), we found that Zeb1 was up-regulated during the early stages of transdifferentiation...
May 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28492703/prehispanic-guanches-mummies-and-natrium-salts-in-burial-caves-of-las-ca%C3%A3-adas-del-teide-tenerife
#10
Matilde Arnay-de-la-Rosa, Emilio González-Reimers, Sergio Pou-Hernández, Efraím Marrero-Salas, Carlos García-Avila
The prehispanic population of Tenerife (Guanches) buried their dead in caves. Many corpses are totally or partially mummified. Embalming procedures are largely unknown, besides some information recorded by chroniclers and the general idea that environmental conditions in some areas may favour natural mummification. Detailed observation of burial caves containing mummified corpses revealed the presence of a white mineral in form of crusts or powder that was not present in the vast majority of non-burial caves, especially in basaltic and trachybasaltic lava flows...
April 4, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28489585/pou2f1-over-expression-correlates-with-poor-prognoses-and-promotes-cell-growth-and-epithelial-to-mesenchymal-transition-in-hepatocellular-carcinoma
#11
Yonghao Zhong, Hongyang Huang, Min Chen, Jinzhou Huang, Qingxia Wu, Guang-Rong Yan, De Chen
Despite recent efforts to understand activities of POU domain class 2 transcription factor 1 (POU2F1), little is known about the roles of POU2F1 in hepatocellular carcinoma (HCC) tumorigenesis and its correlation with any clinicopathological feature of HCC. In this study, we found that POU2F1 was significantly up-regulated in HCC specimens compared with adjacent non-cancerous liver specimens. The high POU2F1 protein expression level positively correlated with large tumor size, high histological grade, tumor metastasis and advanced clinical stage, and HCC patients with high POU2F1 levels exhibited poor prognoses...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476212/recommendations-of-the-working-groups-from-the-spanish-society-of-intensive-and-critical-care-medicine-and-coronary-units-semicyuc-for-the-management-of-adult-critically-ill-patients
#12
A Hernández-Tejedor, O Peñuelas, G Sirgo Rodríguez, J A Llompart-Pou, E Palencia Herrejón, A Estella, M P Fuset Cabanes, M A Alcalá-Llorente, P Ramírez Galleymore, B Obón Azuara, J A Lorente Balanza, C Vaquerizo Alonso, M A Ballesteros Sanz, M García García, J Caballero López, A Socias Mir, A Serrano Lázaro, J M Pérez Villares, M E Herrera-Gutiérrez
The standardization of the Intensive Care Medicine may improve the management of the adult critically ill patient. However, these strategies have not been widely applied in the Intensive Care Units (ICUs). The aim is to elaborate the recommendations for the standardization of the treatment of critical patients. A panel of experts from the thirteen working groups (WG) of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) was selected and nominated by virtue of clinical expertise and/or scientific experience to carry out the recommendations...
June 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28463945/epidemiology-of-fractures-in-children-younger-than-12-months
#13
Diana Rodà, Victoria Trenchs, Ana Isabel Curcoy, Anibal Dolores Martínez, Jordi Pou, Carles Luaces
OBJECTIVES: The aim of this study is to determine the prevalence and characteristics of fractures in young infants attended at the pediatric emergency department (PED). METHODS: This is a retrospective study for 2 years (2011-2012) of children younger than 12 months attended with a fracture at the PED. Age, sex, site and type of fracture, mechanism of injury, time interval before seeking medical attention, and management were analyzed. RESULTS: One hundred one patients were included...
May 1, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28453841/the-use-of-quinacrine-in-nitroimidazole-resistant-giardia-duodenalis-an-old-drug-for-an-emerging-problem
#14
Ana Requena-Méndez, Pilar Goñi, Encarnación Rubio, Diana Pou, Victoria Fumadó, Silvia Lóbez, Edelweiss Aldasoro, Juan Cabezos, Maria Eugenia Valls, Begoña Treviño, Antonio Federico Martínez Montseny, Antonio Clavel, Joaquim Gascon, José Muñoz
Background.: There is little evidence regarding the management of refractory giardiasis after treatment with nitroimidazoles. This study estimates the proportion of persistent giardiasis in 3 hospitals in Barcelona, describes associated risk factors and genotype, and evaluates the efficacy rate of quinacrine in those with persistent giardiasis. Methods.: A clinical, prospective, observational study was conducted in patients with giardiasis treated with nitroimidazoles...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28436273/proteome-analysis-of-sheep-b-lymphocytes-in-the-course-of-bovine-leukemia-virus-induced-leukemia
#15
Michal Reichert
Presented are the results of a study of the expression pattern of different proteins in the course of bovine leukemia virus-induced leukemia in experimental sheep and I discuss how the obtained data may be useful in gaining a better understanding of the pathogenesis of the disease, diagnosis, and for the selection of possible therapeutic targets. In cattle, the disease is characterized by life-long persistent lymphocytosis leading to leukemia/lymphoma in about 5% of infected animals. In sheep, as opposed to cattle, the course of the disease is always fatal and clinical symptoms usually occur within a three-year period after infection...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28431433/experimental-anterior-ischemic-optic-neuropathy-in-diabetic-mice-exhibited-severe-retinal-swelling-associated-with-vegf-elevation
#16
Ming-Hui Sun, Mohammad Ali Shariati, Yaping Joyce Liao
Purpose: Diabetes mellitus (DM) is one of the most important risk factors for nonarteritic anterior ischemic optic neuropathy (AION). In this study, we investigated for the first time the impact of experimental AION in a DM model. Methods: We induced a photochemical thrombosis model of AION after streptozotocin-induced DM and performed serial optical coherence tomography (OCT), morphometric analyses, and VEGF levels in the retina and sera. Results: Compared with non-DM animals, experimental AION in DM mice led to significantly greater retinal swelling on day 1 and worse thinning at week 3 on OCT measurements...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28430310/vascular-access-for-hemodialysis-and-tattoos-a-consideration-to-bear-in-mind
#17
Vicent Esteve Simó, Lucia Martínez Carnovale, Lorenzo Álvarez Rodríguez, Ezequiel Paredes Mariñas, Mónica Pou Potau, Antonio De la Torre Morán, Manel Ramírez de Arellano Serna
No abstract text is available yet for this article.
April 18, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28410371/determining-the-role-of-missense-mutations-in-the-pou-domain-of-hnf1a-that-reduce-the-dna-binding-affinity-a-computational-approach
#18
Sneha P, Thirumal Kumar D, George Priya Doss C, Siva R, Hatem Zayed
Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the Hepatocyte Nuclear Factor 1 Alpha (HNF1A) with MODY3. Missense mutations in the POU homeodomain (POUH) of HNF1A hinder binding to the DNA, thereby leading to a dysfunctional protein. Missense mutations of the HNF1A were retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism...
2017: PloS One
https://www.readbyqxmd.com/read/28402059/molecular-markers-of-putative-spermatogonial-stem-cells-in-the-domestic-cat
#19
S J Bedford-Guaus, S Kim, L Mulero, J M Vaquero, C Morera, R Adan-Milanès, A Veiga, Á Raya
Spermatogonial stem cells (SSCs) are an important tool for fertility preservation and species conservation. The ability to expand SSCs by in vitro culture is a crucial premise for their use in assisted reproduction. Because SSCs represent a small proportion of the germ cells in the adult testis, culture success is aided by pre-enrichment through sorting techniques based on cell surface-specific markers. Given the importance of the domestic cat as a model for conservation of endangered wild felids, herein we sought to examine culture conditions as well as molecular markers for cat SSCs...
April 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28399482/functionalized-polymer-iron-oxide-hybrid-nanofibers-electrospun-filtration-devices-for-metal-oxyanion-removal
#20
Katherine T Peter, Adam J Johns, Nosang V Myung, David M Cwiertny
Via a single-pot electrospinning synthesis, we developed a functionalized polymer-metal oxide nanofiber filter for point of use (POU) water treatment of metal oxyanions (e.g., arsenate and chromate). Polyacrylonitrile (PAN) functionalization was accomplished by inclusion of surface-active, quaternary ammonium salts (QAS) [cetyltrimethylammonium bromide (CTAB) or tetrabutylammonium bromide (TBAB)] that provide strong base ion exchange sites. Embedded iron oxide [ferrihydrite (Fh)] nanoparticles were used for their established role as metal sorbents...
June 15, 2017: Water Research
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