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https://www.readbyqxmd.com/read/29773901/ets-1-promoter-associated-noncoding-rna-regulates-the-nono-erg-ets-1-axis-to-drive-gastric-cancer-progression
#1
Dan Li, Yajun Chen, Hong Mei, Wanju Jiao, Huajie Song, Lin Ye, Erhu Fang, Xiaojing Wang, Feng Yang, Kai Huang, Liduan Zheng, Qiangsong Tong
Emerging studies have indicated the essential functions of long noncoding RNAs (lncRNAs) during cancer progression. However, whether lncRNAs contribute to the upregulation of v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1), an established oncogenic protein facilitating tumor invasion and metastasis, in gastric cancer remains elusive. Herein, we identified Ets-1 promoter-associated noncoding RNA (pancEts-1) as a novel lncRNA associated with the gastric cancer progression via mining of publicly available datasets and rapid amplification of cDNA ends...
May 18, 2018: Oncogene
https://www.readbyqxmd.com/read/29753229/novel-agnws-pan-tpu-membrane-for-point-of-use-drinking-water-electrochemical-disinfection
#2
Xiaojun Tan, Chao Chen, Yongyou Hu, Junjie Wen, Yanzhe Qin, Jianhua Cheng, Yuancai Chen
The safety of drinking water remains a major challenge in developing countries and point-of-use (POU) drinking water treatment device plays an important role in decentralised drinking water safety. In this study, a novel material, i.e. a silver nanowires-polyacrylonitrile/thermoplastic polyurethane (AgNWs-PAN/TPU) composite membrane, was fabricated via electrospinning and vacuum filtration deposition. Morphological and structural characterisation showed that the PAN/TPU fibres had uniform diameters and enhanced mechanical properties...
May 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29747467/electrochemical-detection-of-e-coli-o157-h7-in-water-after-electrocatalytic-and-ultraviolet-treatments-using-a-polyguanine-labeled-secondary-bead-sensor
#3
Michael G Beeman, Ugochukwu C Nze, Himanshu J Sant, Hammad Malik, Swomitra Mohanty, Bruce K Gale, Krista Carlson
The availability of clean drinking water is a significant problem worldwide. Many technologies exist for purifying drinking water, however, many of these methods require chemicals or use simple methods, such as boiling and filtering, which may or may not be effective in removing waterborne pathogens. Present methods for detecting pathogens in point-of-use (POU) sterilized water are typically time prohibitive or have limited ability differentiating between active and inactive cells. This work describes a rapid electrochemical sensor to differentially detect the presence of active Escherichia coli (E...
May 10, 2018: Sensors
https://www.readbyqxmd.com/read/29741366/metagenomic-characterization-of-antibiotic-resistance-genes-in-full-scale-reclaimed-water-distribution-systems-and-corresponding-potable-systems
#4
Emily Garner, Chaoqi Chen, Kang Xia, Jolene Bowers, David Engelthaler, Jean McLain, Marc A Edwards, Amy Pruden
Water reclamation provides a valuable resource for meeting non-potable water demands. However, little is known about the potential for wastewater reuse to disseminate antibiotic resistance genes (ARGs). Here, samples were collected seasonally in 2014-2015 from four U.S. utilities' reclaimed and potable water distribution systems before treatment, after treatment, and at five points of use (POU). Shotgun metagenomic sequencing was used to profile the resistome (i.e., full contingent of ARGs) of a subset (n=38) of samples...
May 9, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29733647/adherence-to-point-of-use-water-treatment-over-short-term-implementation-parallel-crossover-trials-of-flocculation-disinfection-sachets-in-pakistan-and-zambia
#5
Ameer Shaheed, Sohail Rathore, Andy Bastable, Jane Bruce, Sandy Cairncross, Joe Brown
The health benefits of point-of-use (POU) water treatment can only be realized through high adherence: correct, consistent, and sustained use. We conducted parallel randomized, longitudinal crossover trials measuring short-term adherence to two single-use flocculant-disinfectant sachets in Pakistan and Zambia. In both trials, adherence declined sharply for both products over the eight-week surveillance periods, with overall lower adherence to both products in Zambia. There was no significant difference in adherence between the two products...
May 7, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29726400/atomic-scale-defects-and-electronic-properties-of-transferred-synthesized-mos-sub-2-sub-monolayer
#6
Ida Delač Marion, Davor Čapeta, Borna Pielic, Fabio Faraguna, Aurelio Gallardo, Pablo Pou, Blanca Biel, Nataša Vujičić, Marko Kralj
MoS<sub>2</sub> monolayer samples were synthesized on SiO<sub>2</sub>/Si wafer and transferred to Ir(111) for nano-scale characterization. Samples were extensively characterized during every step of the transfer process, and MoS<sub>2</sub> on the final substrate examined down to the atomic level by scanning tunneling microscopy (STM). Conducted procedures yielded high quality monolayer MoS<sub>2</sub> of milimeter-scale size with an average defect density of 2×10<sup>13</sup>/cm<sup>2</sup>...
May 4, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29721570/unveiling-the-atomistic-mechanisms-for-oxygen-intercalation-in-a-strongly-interacting-graphene-metal-interface
#7
Carlos Romero-Muñiz, Ana Martín-Recio, Pablo Pou, José M Gómez-Rodríguez, Rubén Pérez
The atomistic mechanisms involved in the oxygen (O) intercalation in the strongly interacting graphene (G) on Rh(111) system are characterized in a comprehensive experimental and theoretical study, combining scanning tunneling microscopy and density functional theory (DFT) calculations. Experimental evidence points out that the G areas located just above the metallic steps of the substrate are the active sites for initializing the intercalation process when some micro-etching points appear after molecular oxygen gas exposure...
May 3, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29707663/ultraviolet-germicidal-irradiation-in-tap-water-contaminated-by-aspergillus-spp
#8
M Sisti, G F Schiavano, M DE Santi, G Brandi
We investigated the effect of ultraviolet germicidal irradiation (UVI) from a low-pressure mercury lamp on several pathogenic Aspergillus spp. including A. flavipes, A. flavus, A. fumigatus, A. glaucus, A. nidulans, A. niger, A. terreus, A. ustus and A. versicolor suspended in tap water under laboratory-scale conditions. It was shown that within 10 s of exposure, time species such as A. glaucus, A. niudulans and A. ustus were completely inactivated, while 40 s were needed for the elimination of all the species tested...
December 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/29695419/hepatitis-c-virus-ns5a-protein-promotes-the-lysosomal-degradation-of-hepatocyte-nuclear-factor-1%C3%AE-via-chaperone-mediated-autophagy
#9
Chieko Matsui, Lin Deng, Nanae Minami, Takayuki Abe, Kazuhiko Koike, Ikuo Shoji
Hepatitis C virus (HCV) infection is closely associated with type 2 diabetes. We reported that HCV infection induces the lysosomal degradation of hepatocyte nuclear factor 1alpha (HNF-1α) via interaction with HCV NS5A protein, thereby suppressing GLUT2 gene expression. Molecular mechanisms of selective degradation of HNF-1α caused by NS5A are largely unknown. Chaperone-mediated autophagy (CMA) is a selective lysosomal degradation pathway. Here, we investigated whether CMA is involved in the selective degradation of HNF-1α in HCV-infected cells and observed that the pentapeptide spanning from aa 130 to aa 134 of HNF-1α matches the rule for the CMA-targeting motif, also known as KFERQ motif...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29691971/hydroxychloroquine-may-be-associated-with-reduced-risk-of-coronary-artery-diseases-in-patients-with-rheumatoid-arthritis-a-nationwide-population-based-cohort-study
#10
Yao-Min Hung, Yu-Hsun Wang, Lichi Lin, Paul Yung Pou Wang, Jeng-Yuan Chiou, James Cheng-Chung Wei
OBJECTIVES: The aim of this study was to determine whether hydroxychloroquine (HCQ) usage is associated with incidental risk of coronary artery diseases (CAD) in patients with rheumatoid arthritis (RA). METHODS: The Longitudinal Health Insurance Database in Taiwan was used. The study cohort comprised of 1104 newly diagnosed RA patients between 2001-2010, and patients were followed until 31 December 2011. Patients with history of CAD before RA diagnosis were excluded...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29681543/the-pou-oct-transcription-factor-nubbin-controls-the-balance-of-intestinal-stem-cell-maintenance-and-differentiation-by-isoform-specific-regulation
#11
Xiongzhuo Tang, Yunpo Zhao, Nicolas Buchon, Ylva Engström
Drosophila POU/Oct transcription factors are required for many developmental processes, but their putative regulation of adult stem cell activity has not been investigated. Here, we show that Nubbin (Nub)/Pdm1, homologous to mammalian OCT1/POU2F1 and related to OCT4/POU5F1, is expressed in gut epithelium progenitor cells. We demonstrate that the nub-encoded protein isoforms, Nub-PB and Nub-PD, play opposite roles in the regulation of intestinal stem cell (ISC) maintenance and differentiation. Depletion of Nub-PB in progenitor cells increased ISC proliferation by derepression of escargot expression...
April 17, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29673854/silencing-of-non-pou-domain-containing-octamer-binding-protein-stabilizes-atherosclerotic-plaque-in-apolipoprotein-e-knockout-mice-via-nf-%C3%AE%C2%BAb-signaling-pathway
#12
Kai Zhang, Fang Zhang, Jian-Min Yang, Jing Kong, Xiao Meng, Meng Zhang, Cheng Zhang, Yun Zhang
BACKGROUND: It remains unknown whether Non-POU-domain-containing octamer-binding protein (NonO) plays a causative role in plaque destabilization. We hypothesized that NonO gene silencing may stabilize atherosclerotic plaque by increasing P4Hα1 expression and inhibiting the inflammation. METHODS AND RESULTS: Vulnerable atherosclerotic plaques were induced in ApoE-/- mice by high fat diet, perivascular collar placement and mental stress. Compared with normal carotid arteries, those contained vulnerable plaques had high NonO expression...
April 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29661567/geriatric-traumatic-brain-injury-an-old-challenge
#13
J A Llompart-Pou, J Pérez-Bárcena
No abstract text is available yet for this article.
April 13, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29604293/immune-cell-production-of-interleukin-17-induces-stem-cell-features-of-pancreatic-intraepithelial-neoplasia-cells
#14
Yu Zhang, Michelle Zoltan, Erick Riquelme, Hanwen Xu, Ismet Sahin, Susana Castro-Pando, Maria Fernanda Montiel, Kyle Chang, Zhengyu Jiang, Jianhua Ling, Sonal Gupta, William Horne, Melissa Pruski, Huamin Wang, Shao-Cong Sun, Guillermina Lozano, Paul Chiao, Anirban Maitra, Steven D Leach, Jay K Kolls, Eduardo Vilar Sanchez, Timothy C Wang, Jennifer M Bailey, Florencia McAllister
BACKGROUND & AIMS: Little is known about how the immune system affects stem cell features of pancreatic cancer cells. Immune cells that produce interleukin 17 A (IL17A) in the chronically inflamed pancreas (chronic pancreatitis) contribute to PanIN initiation and progression. We investigated the effects of IL17A signaling exerts on pancreatic cancer progenitor cells and the clinical relevance of this phenomena. METHODS: We performed studies with Mist1Cre;LSLKras;Rosa26mTmG (KCiMist ;G) and Kras(G12D); Trp53(R172H); Pdx1-Cre (KPC) mice (which upon tamoxifen induction spontaneously develop pancreatic intraepithelial neoplasias, PanINs) and control littermates...
March 28, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29578472/bioinformatics-analysis-of-novel-transcription-factors-and-related-differentially-regulated-modules-in-non-union-skeletal-fractures
#15
Jun Zhang
This study aimed to further clarify the underlying pathomechanism of non-union skeletal fractures.Gene expression profile dataset GSE494 obtained from six non-union skeletal fracture and six normal samples was downloaded from the Gene Expression Omnibus database. Overlapping genes in at least two platforms were analyzed, and differentially expressed genes (DEGs) between normal and disease groups were screened. Transcriptional regulatory relationships and differentially regulated modules of various transcription factors (TFs) were determined...
March 16, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29578181/identification-of-key-genes-related-to-high-risk-gastrointestinal-stromal-tumors-using-bioinformatics-analysis
#16
Shuan Jin, Wenhua Zhu, Jun Li
Aim: The purpose of this study was to identify predictive biomarkers used for clinical therapy and prognostic evaluation of high-risk gastrointestinal stromal tumors (GISTs). Materials and Methods: In this study, microarray data GSE31802 were used to identify differentially expressed genes (DEGs) between high-risk GISTs and low-risk GISTs. Then, enrichment analysis of DEGs was conducted based on the gene ontology and kyoto encyclopedia of genes and genomes pathway database...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29568879/retinal-ganglion-cell-conditioned-medium-and-surrounding-pressure-alters-gene-expression-and-differentiation-of-rat-retinal-progenitor-cells
#17
Min Dai, Qing Zhang, Zhikun Zheng, Jianzhou Wang
Loss of retinal ganglion cells is implicated in glaucoma and high intraocular pressure. Factors that affect the differentiation of retinal progenitor cells into retinal ganglion cells remain unclear. The present study aimed to investigate the effects of retinal ganglion cell‑conditioned medium on gene expression and differentiation in retinal progenitor cells, and the effects of surrounding pressure on the survival and differentiation of retinal progenitor cells. Retinal progenitor cells and retinal ganglion cells were isolated from rats...
March 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29564752/te-wh%C3%A4-nau-pou-toru-a-randomized-controlled-trial-rct-of-a-culturally-adapted-low-intensity-variant-of-the-triple-p-positive-parenting-program-for-indigenous-m%C3%A4-ori-families-in-new-zealand
#18
Louise J Keown, Matthew R Sanders, Nike Franke, Matthew Shepherd
Evidence-based parenting support programs (EBPS) based on social learning and cognitive behavioral principles are effective in reducing conduct-related problems in a diverse range of cultural contexts. However, much less is known about their effects with indigenous families. A Collaborative Participation Adaptation Model (CPAM) was used to culturally adapt a low-intensity, two-session group variant of the Triple P-Positive Parenting Program for Māori parents of young children in New Zealand. CPAM involved collaborating closely with Māori tribal elders, practitioners as end-users, and parents as consumers through a participatory process to identify content and delivery process used in Triple P that would ensure that traditional Māori cultural values were incorporated...
March 22, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29559880/acute-calcific-tendonitis-of-the-longus-colli
#19
Blake S Raggio, Samuel C Ficenec, Jason Pou, Brian Moore
Background: Acute calcific tendonitis of the longus colli (ACTLC) is an aseptic inflammatory response to deposition of calcium in the longus colli muscle tendons. Although reports in the literature are scarce, ACTLC likely represents an underreported disease process that routinely goes misdiagnosed. We report a case of ACTLC and provide a brief review of the literature. Case Report: A 45-year-old otherwise healthy female presented with a 3-day history of progressive neck pain, decreased neck mobility, and odynophagia...
2018: Ochsner Journal
https://www.readbyqxmd.com/read/29559870/the-submental-island-flap-is-a-viable-reconstructive-option-for-a-variety-of-head-and-neck-ablative-defects
#20
Blair M Barton, Charles A Riley, Jason D Pou, Christian P Hasney, Brian A Moore
Background: The submental island flap (SIF) is a pedicled flap based upon the submental artery and vein. Its utility in reconstruction following ablative head and neck procedures has been applied to various subsites including skin, lip, buccal mucosa, retromolar trigone, parotidectomy defects, and tongue. We review our experience using the SIF for reconstruction following tumor ablation. Methods: This prospective case series with medical record review includes consecutive patients undergoing SIF reconstruction following ablative surgery for malignancy at a single tertiary care facility between November 2014 and November 2016...
2018: Ochsner Journal
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