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https://www.readbyqxmd.com/read/29337206/evolution-of-the-pou1f1-transcription-factor-in-mammals-rapid-change-of-the-alternatively-spliced-%C3%AE-domain
#1
Michael Wallis
The POU1F1 (Pit-1) transcription factor is important in regulating expression of growth hormone, prolactin and TSH β -subunit, and controlling development of the anterior pituitary cells in which these hormones are produced. POU1F1 is a conserved protein comprising three main domains, an N-terminal transcription activation domain (TAD), a POU-specific domain and a C-terminal homeodomain. Within the TAD, a β -domain can be inserted by alternative splicing, giving an extended ' β -variant' with altered properties...
January 11, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29335749/diversity-among-pou-transcription-factors-in-chromatin-recognition-and-cell-fate-reprogramming
#2
REVIEW
Vikas Malik, Dennis Zimmer, Ralf Jauch
The POU (Pit-Oct-Unc) protein family is an evolutionary ancient group of transcription factors (TFs) that bind specific DNA sequences to direct gene expression programs. The fundamental importance of POU TFs to orchestrate embryonic development and to direct cellular fate decisions is well established, but the molecular basis for this activity is insufficiently understood. POU TFs possess a bipartite 'two-in-one' DNA binding domain consisting of two independently folding structural units connected by a poorly conserved and flexible linker...
January 15, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29311716/discovering-viral-genomes-in-human-metagenomic-data-by-predicting-unknown-protein-families
#3
Mauricio Barrientos-Somarribas, David N Messina, Christian Pou, Fredrik Lysholm, Annelie Bjerkner, Tobias Allander, Björn Andersson, Erik L L Sonnhammer
Massive amounts of metagenomics data are currently being produced, and in all such projects a sizeable fraction of the resulting data shows no or little homology to known sequences. It is likely that this fraction contains novel viruses, but identification is challenging since they frequently lack homology to known viruses. To overcome this problem, we developed a strategy to detect ORFan protein families in shotgun metagenomics data, using similarity-based clustering and a set of filters to extract bona fide protein families...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305536/pou6f1-mediates-neuropeptide-dependent-plasticity-in-the-adult-brain
#4
Cynthia K McClard, Mikhail Y Kochukov, Isabella Herman, Zhandong Liu, Aiden Eblimit, Yalda Moayedi, Joshua Ortiz-Guzman, Daniel Colchado, Brandon Pekarek, Sugi Paneerselvam, Graeme Mardon, Benjamin R Arenkiel
The mouse olfactory bulb (OB) features continued, activity-dependent integration of adult-born neurons, providing a robust model to examine mechanisms of plasticity in the adult brain. We previously reported that local OB interneurons secrete the neuropeptide corticotropin releasing hormone (CRH) in an activity-dependent manner onto adult-born granule neurons, and that local CRH signaling promotes expression of synaptic machinery in the bulb. This effect is mediated via activation of the CRH receptor 1 (CRHR1), which is developmentally regulated during adult-born neuron maturation...
January 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29281652/basalt-geochemistry-reveals-high-frequency-of-prehistoric-tool-exchange-in-low-hierarchy-marquesas-islands-polynesia
#5
Andrew McAlister, Melinda S Allen
Exchange activities, formal or otherwise, serve a variety of purposes and were prominent in many Pacific Island societies, both during island settlement and in late prehistory. Recent Polynesian studies highlight the role of exchange in the region's most hierarchical polities where it contributed to wealth economies, emergent leadership, and status rivalry in late prehistory. Building on this research, we hypothesized that exchange in low hierarchy chiefdoms (kin-based polities where there are distinctions between commoners and elites but ranking within the latter is lacking, weak, or ephemeral) would differ in frequency and function from that associated with strongly hierarchical polities...
2017: PloS One
https://www.readbyqxmd.com/read/29274087/human-enteric-viruses-in-a-wastewater-treatment-plant-evaluation-of-activated-sludge-combined-with-uv-disinfection-process-reveals-different-removal-performances-for-viruses-with-different-features
#6
A Lizasoain, L F L Tort, M García, L Gillman, A Alberti, J P G Leite, M P Miagostovich, S A Pou, A Cagiao, A Razsap, J Huertas, M Berois, M Victoria, R Colina
This study assess the quality of wastewater through the detection and quantification of important causing gastroenteritis viruses at different stages of the wastewater treatment process in an activated-sludge wastewater treatment plant with ultraviolet disinfection. Ten sampling events were carried out in a campaign along a period of 18 months collecting wastewater samples from the influent, after the activated sludge treatment, and after the final disinfection with UV radiation. Samples were concentrated through ultracentrifugation and analyzed using retro-transcription, PCR and real time quantitative PCR protocols, for detection and quantification of Group A Rotavirus (RVA), Human Astrovirus (HAstV), Norovirus Genogroup II (NoV GII) and Human Adenovirus (HAdV)...
December 22, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29223077/multiple-linear-regression-based-congener-profile-correlation-to-estimate-the-toxicity-teq-and-dioxin-concentration-in-atmospheric-emissions
#7
D Palmer, J O Pou, L Gonzalez-Sabaté, J Díaz-Ferrero
The formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) is governed by complex chemical reactions with complex kinetic models. The simulation of Municipal Solid Waste incinerators, or other industrial thermal processes, is a powerful tool that can be used to optimize and control them, and reducing the number of components to simulate is mandatory for a proper use. In this study it has been determined that only the formation of 3 of the 17 main PCDD/F congeners can be considered as linearly independent...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29216297/skn-1a-pou2f3-functions-as-a-master-regulator-to-generate-trpm5-expressing-chemosensory-cells-in-mice
#8
Junpei Yamashita, Makoto Ohmoto, Tatsuya Yamaguchi, Ichiro Matsumoto, Junji Hirota
Transient receptor potential channel M5 (Trpm5)-expressing cells, such as sweet, umami, and bitter taste cells in the oropharyngeal epithelium, solitary chemosensory cells in the nasal respiratory epithelium, and tuft cells in the small intestine, that express taste-related genes function as chemosensory cells. Previous studies demonstrated that Skn-1a/Pou2f3, a POU homeodomain transcription factor is expressed in these Trpm5-expressing chemosensory cells, and is necessary for their generation. Trpm5-expressing cells have recently been found in trachea, auditory tube, urethra, thymus, pancreatic duct, stomach, and large intestine...
2017: PloS One
https://www.readbyqxmd.com/read/29198453/effects-of-rotigotine-on-clinical-symptoms-quality-of-life-and-sleep-hygiene-adequacy-in-haemodialysis-associated-restless-legs-syndrome
#9
Vicent Esteve, Jose Carneiro, Gabriel Salazar, Mónica Pou, Irati Tapia, Miquel Fulquet, Verónica Duarte, Anna Saurina, Fátima Moreno, Manel Ramírez de Arellano
BACKGROUND: Restless legs syndrome (RLS) is a neurological disorder characterised by bothersome symptoms associated with impaired quality of life and sleep hygiene. Rotigotine is a novel therapeutic alternative, although few studies have been published in patients on haemodialysis (HD) with RLS treated with rotigotine. OBJECTIVES: 1.- To establish the prevalence of RLS in our HD unit. 2.- To evaluate the efficacy and safety profile of rotigotine and its effect on symptoms, quality of life and sleep hygiene in our HD population with RLS...
November 30, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29194880/zika-virus-dynamics-in-body-fluids-and-risk-of-sexual-transmission-in-a-non-endemic-area
#10
Adrián Sánchez-Montalvá, Diana Pou, Elena Sulleiro, Fernando Salvador, Cristina Bocanegra, Begoña Treviño, Ariadna Rando, Núria Serre, Tomàs Pumarola, Benito Almirante, Israel Molina
OBJECTIVE: To understand Zika virus (ZIKV) dynamics in fluids of infected individuals and the risk of sexual transmission. METHODS: Prospective study at two centers in Spain. Patients with probable or confirmed diagnosis of ZIKV infection were clinically followed up and fluid samples were collected from saliva, serum, urine and semen or vaginal secretion following the study protocol. Non-traveler-sexual partners were offered to participate. RESULTS: From January 2016 to December 2016 we included a total of 11 traveler patients and 6 sexual contacts...
December 1, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29165223/health-status-of-asylum-seekers-spain
#11
Núria Serre-Delcor, Carlos Ascaso, Antoni Soriano-Arandes, Francisco Collazos Sanchez, Begoña Treviño Maruri, Elena Sulleiro, Diana Pou Ciruelo, Cristina Bocanegra Garcia, Israel Molina Romero
The rising rate of conflicts and the unsafe situation caused by reasons of ethnicity, religion, gender, sexual orientation, political opinion, or nationality entail an increase in the number of migratory movements. The goal of this article is to describe the health status of asylum seekers visited in an international health center. We conducted a retrospective study of the asylum seekers visited between July 2013 and June 2016. A total of 303 cases were included. The median age was 28.0 years (interquartile range [IQR]: 21-35), and 203 (67...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29155325/promoter-activity-and-regulation-of-the-pou5f1-homolog-from-a-teleost-nile-tilapia
#12
Wei Jing, Huang Xiaohuan, Fan Zhenhua, Yang Zhuo, Da Fan, Tao Wenjing, Zhou Linyan, Wang Deshou
Mammalian POU5F1 (also known as OCT4) is an essential transcription factor that induces and controls stemness in the inner cell mass and embryonic stem (ES) cells. Its expression results from intricate regulatory networks involving its 5' upstream DNA elements and numerous transcription factors. Pou5f3, the ortholog of POU5F1, has been identified in non-mammalians including fish. However, little is known about the molecular mechanisms controlling its expression up to date. Here we report the promoter activity and regulation of Nile tilapia (Oreochromis niloticus) pou5f3 (Onpou5f3) in fish early-stage embryos and ES cells...
November 16, 2017: Gene
https://www.readbyqxmd.com/read/29153991/serine-347-phosphorylation-by-jnks-negatively-regulates-oct4-protein-stability-in-mouse-embryonic-stem-cells
#13
Ki Beom Bae, Dong Hoon Yu, Kun Yeong Lee, Ke Yao, Joohyun Ryu, Do Young Lim, Tatyana A Zykova, Myoung Ok Kim, Ann M Bode, Zigang Dong
The POU transcription factor OCT4 is critical for maintaining the undifferentiated state of embryonic stem cells (ESCs) and generating induced pluripotent stem cells (iPSCs), but its precise mechanisms of action remain poorly understood. Here, we investigated the role of OCT4 phosphorylation in the biological functions of ESCs. We observed that c-Jun N-terminal kinases (JNKs) directly interacted with and phosphorylated OCT4 at serine 347, which inhibited the transcriptional activity of OCT4. Moreover, phosphorylation of OCT4 induced binding of FBXW8, which reduced OCT4 protein stability and enhanced its proteasomal degradation...
November 10, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29150929/biomechanical-properties-of-feline-ventral-abdominal-wall-and-celiotomy-closure-techniques
#14
Fernando S Reina Rodriguez, Conor T Buckley, Joshua Milgram, Barbara M Kirby
OBJECTIVE: To compare biomechanical properties and mechanism of failure of 3 regions of ventral abdominal wall in cats by using 2 suture materials, 2 suture bite-to-stitch intervals (SBSI), and full-thickness versus fascia-only closure. STUDY DESIGN: Randomized, cadaveric, ex vivo mechanical testing. SAMPLE POPULATION: 16 adult cat cadavers, 3 samples per cat. METHODS: Three regions of ventral abdominal wall were mechanically tested (N = 48 samples)...
November 18, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29143399/buprenorphine-naloxone-treatment-responses-differ-between-young-adults-with-heroin-and-prescription-opioid-use-disorders
#15
Mauricio Romero-Gonzalez, Abtin Shahanaghi, Gregory J DiGirolamo, Gerardo Gonzalez
BACKGROUND AND OBJECTIVES: Opioid use disorder among young adults is rising sharply with an increase in morbidity and mortality. This study examined differences in treatment response to a fixed dose of buprenorphine-naloxone between heroin (HU) and prescriptions opioids (POU) users. METHODS: Eighty opioid dependent young adults (M = 22 years) were treated with buprenorphine-naloxone 16-4 mg/day for 8 weeks. Differences between HU (N = 17) and POU (N = 63) on changes in weekly opioid use, opioid craving, withdrawal, and depression symptoms were analyzed with mixed-effects regression models...
December 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29140733/proinflammatory-dietary-intake-is-associated-with-increased-risk-of-colorectal-cancer-results-of-a-case-control-study-in-argentina-using-a-multilevel-modeling-approach
#16
Camila Niclis, Sonia A Pou, Nitin Shivappa, James R Hébert, Susan E Steck, María Del Pilar Díaz
Little evidence regarding the inflammatory potential of diet and its effect on colorectal cancer exists in Latin American countries. The aim of the present study was to evaluate the association between the Dietary Inflammatory Index (DII®) and colorectal cancer (CRC) risk in Córdoba, Argentina. A frequency-matched case-control study (N = 446, including 144 (32.3%) CRC cases and 302 (67.7%) controls was conducted in Córdoba (Argentina) from 2008 through 2015. DII® scores were computed based on dietary intake assessed by a validated food frequency questionnaire (FFQ)...
November 15, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29119857/mir-638-inhibits-immature-sertoli-cell-growth-by-indirectly-inactivating-pi3k-akt-pathway-via-spag1-gene
#17
Pandi Hu, Kaifeng Guan, Yue Feng, Changping Ma, Huibin Song, Yang Li, Xuanyan Xia, Jialian Li, Fenge Li
Numerous studies have demonstrated that microRNAs (miRNAs) play important roles in cell growth, apoptosis and spermatogenesis. Our previous study showed that miR-638 was differentially expressed in sexually immature and mature testes of Large White boars. Here we reported that sperm-associated antigen 1 (SPAG1) was a direct target gene of miR-638. Moreover, miR-638 inhibited cell proliferation and cell cycle, and promoted apoptosis of porcine immature Sertoli cells. Key genes including phosphorylated phosphatidylinositide 3-kinases (p-PI3K) and phosphorylated serine/ threonine kinase (p-AKT) in PI3K/AKT pathway as well as cell cycle factors including c-MYC, cyclin-D1 (CCND1), cyclin-E1 (CCNE1) and cyclin-dependent kinase 4 (CDK4) were all significantly down-regulated after overexpression of miR-638 or RNAi of SPAG1...
November 9, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29113774/restricted-presence-of-pou6f2-in-human-corneal-endothelial-cells-uncovered-by-extension-of-the-promoter-level-expression-atlas
#18
Masahito Yoshihara, Susumu Hara, Motokazu Tsujikawa, Satoshi Kawasaki, Yoshihide Hayashizaki, Masayoshi Itoh, Hideya Kawaji, Kohji Nishida
Corneal endothelial cells (CECs) are essential for maintaining the clarity of the cornea. Because CECs have limited proliferative ability, interest is growing in their potentially therapeutic regeneration from pluripotent stem cells. However, the molecular mechanisms of human CEC differentiation remain largely unknown. To determine the key regulators of CEC characteristics, here we generated a comprehensive promoter-level expression profile of human CECs, using cap analysis of gene expression (CAGE) with a single molecule sequencer...
November 2017: EBioMedicine
https://www.readbyqxmd.com/read/29106297/developments-in-micro-and-nanotechnology-for-foodborne-pathogen-detection
#19
Krista Carlson, Manoranjan Misra, Swomitra Mohanty
In response to the potential hazards associated with the globalization of the food industry, research has been focused on the development of new sensing techniques to provide the means of contamination detection at any stage in the food supply chain. The demand for on-site detection is growing as pre-emptive sensing of pathogens could eliminate foodborne-related outbreaks and associated healthcare costs. Reduction in food waste is also a driver for point-of-use (POU) sensing, from both an economic and environmental standpoint...
November 6, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29077289/-predictors-of-drug-resistant-pathogens-in-community-onset-pneumonia-are-factors-considered-in-health-care-associated-pneumonia-useful-in-the-emergency-department
#20
Olga H Torres Bonafonte, Eva Gil Olivas, Estefanía Pérez Macho, Cristina Pacho Pacho, Miriam Mateo Roca, Jordi Casademont Pou, Domingo Ruiz Hidalgo
OBJECTIVES: To analyze factors related to drug-resistant pathogens (DRPs) in community-onset pneumonia (COP) and whether previously suggested criteria are useful in our emergency-department. MATERIAL AND METHODS: Prospective 1-year study of adults coming to the emergency department for COP. We assessed the usefulness of criteria used in health-care-associated pneumonia (HCAP), as well the Shorr index, the Barthel index, and clinical suspicion of resistant pathogens...
October 2017: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
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