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https://www.readbyqxmd.com/read/28817638/the-transcriptional-profiling-of-human-in-vivo-generated-plasma-cells-identifies-selective-imbalances-in-monoclonal-gammopathies
#1
Luis M Valor, Beatriz Rodríguez-Bayona, Ana B Ramos-Amaya, José A Brieva, Antonio Campos-Caro
Plasma cells (PC) represent the heterogeneous final stage of the B cells (BC) differentiation process. To characterize the transition of BC into PC, transcriptomes from human naïve BC were compared to those of three functionally-different subsets of human in vivo-generated PC: i) tonsil PC, mainly consisting of early PC; ii) PC released to the blood after a potent booster-immunization (mostly cycling plasmablasts); and, iii) bone marrow CD138+ PC that represent highly mature PC and include the long-lived PC compartment...
2017: PloS One
https://www.readbyqxmd.com/read/28772222/hyperlactatemia-in-icu-patients-incidence-causes-and-associated-mortality
#2
Mireia Ferreruela, Joan Maria Raurich, Ignacio Ayestarán, Juan Antonio Llompart-Pou
PURPOSE: To describe the incidence, causes and associated mortality of hyperlactatemia in critically ill patients and to evaluate the association between lactate clearance and in-hospital survival. METHODS: Retrospective cohort study of patients with hyperlactatemia admitted to the ICU. Hyperlactatemia was defined as a blood lactate concentration ≥5mmol/L and high-grade hyperlactatemia a lactate level ≥10mmol/L. Lactate clearance was calculated as the percentage of decrease in lactate concentration from the peak value...
July 24, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28760809/genome-wide-identification-of-grainy-head-targets-in-drosophila-reveals-regulatory-interactions-with-the-pou-domain-transcription-factor-vvl
#3
Liqun Yao, Shenqiu Wang, Jakub Orzechowski-Westholm, Qi Dai, Ryo Matsuda, Chie Hosono, Sarah Bray, Eric C Lai, Christos Samakovlis
Grainy head (Grh) is a conserved transcription factor (TF) controlling epithelial differentiation and regeneration. To elucidate Grh functions, we identified embryonic Grh targets by ChIP-seq and gene expression analysis. We show that Grh controls hundreds of target genes. Repression or activation correlates with the distance of Grh binding sites to the transcription start sites of its targets. Analysis of 54 Grh-responsive enhancers during development and upon wounding suggests cooperation with distinct TFs in different contexts...
July 31, 2017: Development
https://www.readbyqxmd.com/read/28760634/tracking-the-spread-routes-of-opportunistic-premise-plumbing-pathogens-in-a-haematology-unit-with-water-points-of-use-protected-by-antimicrobial-filters
#4
Sophie Baranovsky, Estelle Jumas-Bilak, Anne Lotthé, Hélène Marchandin, Sylvie Parer, Yosr Hicheri, Sara Romano-Bertrand
BACKGROUND: Water networks in hospitals are frequently contaminated by Opportunistic Premise Plumbing Pathogens (OPPPs) leading to fitment of antimicrobial filters on water points-of-use (POU) in order to limit patients' exposure. AIM: to assess the spread of OPPPs through secondary water routes (outside the plumbing system) in an adult haematology unit in which 52 out of 73 water POU were high-risk for patients and protected by antimicrobial filters. METHODS: An observational audit identified 6 secondary water routes for which bacteria tracking and typing were performed in 315 surface samplings...
July 28, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28755707/survivorship-morbidity-mortality-malignancy
#5
REVIEW
Kelly M Malloy, Anna M Pou
Survivorship encompasses the entire therapeutic, psychosocial, functional, and financial experience of living with and through a cancer diagnosis. The period of survivorship starts on the day of the cancer diagnosis and lasts until the end of the survivor's life, regardless of the cause of death. The National Cancer Institute's Office of Cancer Survivorship expands the term "survivor" to include, importantly, caregivers, family, and friends close to the survivor who also live through this period.
August 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28750039/resistance-to-the-crayfish-plague-aphanomyces-astaci-oomycota-in-the-endangered-freshwater-crayfish-species-austropotamobius-pallipes
#6
Laura Martín-Torrijos, Miquel Campos Llach, Quim Pou-Rovira, Javier Diéguez-Uribeondo
The pathogen Aphanomyces astaci Schikora 1906 is responsible for the decline of the native crayfish species of Europe, and their current endangered status. This pathogenic species is native to North America and only colonizes aquatic decapods. The North American crayfish species have a high resistance to this pathogen, while species from other regions are highly susceptible. However, recent field and laboratory observations indicate that there might exist some populations with resistance against this disease...
2017: PloS One
https://www.readbyqxmd.com/read/28735722/-is-the-introduction-of-clinical-management-programs-for-patients-with-chronic-obstructive-pulmonary-disease-useful-comparison-of-the-effectiveness-of-two-interventions-on-the-clinical-progress-and-care-received
#7
Ingrid Solanes, Ignasi Bolíbar, Maria Antònia Llauger, Meritxell Peiro, Pepi Valverde, Mar Fraga, Casimira Medrano, Teresa Bigorra, Montserrat Freixas, Iskra Ligüerre, Maria Antònia Pou, Leandra Domínguez, Carles Valero, Judit Solà, Jordi Giner, Vicente Plaza
OBJECTIVE: To evaluate the effectiveness of two management programs on patients with chronic obstructive pulmonary disease (COPD). DESIGN: A study with a quasi-experimental design was used to evaluate the effectiveness of two interventions (I1, I2) for the care of patients with COPD after a mean follow-up of 31.2months. SETTING: Primary Care Centres in two Barcelona Health Areas and their referral hospitals. PARTICIPANTS: Patients with COPD selected by simple random sampling using any disease code corresponding to COPD...
July 20, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28723927/piped-water-supply-interruptions-and-acute-diarrhea-among-under-five-children-in-addis-ababa-slums-ethiopia-a-matched-case-control-study
#8
Metadel Adane, Bezatu Mengistie, Girmay Medhin, Helmut Kloos, Worku Mulat
BACKGROUND: The problem of intermittent piped water supplies that exists in low- and middle-income countries is particularly severe in the slums of sub-Saharan Africa. However, little is known about whether there is deterioration of the microbiological quality of the intermittent piped water supply at a household level and whether it is a factor in reducing or increasing the occurrence of acute diarrhea among under-five children in slums of Addis Ababa. This study aimed to determine the association of intermittent piped water supplies and point-of-use (POU) contamination of household stored water by Escherichia coli (E...
2017: PloS One
https://www.readbyqxmd.com/read/28680048/liver-fat-hepatic-enzymes-alkaline-phosphatase-and-the-risk-of-incident-type-2-diabetes-a-prospective-study-of-132-377-adults
#9
Sean Chun-Chang Chen, Shan Pou Tsai, Jing-Yun Jhao, Wun-Kai Jiang, Chwen Keng Tsao, Ly-Yun Chang
Previous studies have reported inconsistent results of the associations of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) with incident type 2 diabetes (diabetes hereafter). We aimed to resolve the controversy by taking nonalcoholic fatty liver disease (NAFLD) into account. The study population comprised 132,377 non-diabetic individuals (64,875 men and 67,502 women) aged 35-79 who had two or more health examinations during 1996-2014. A total of 6,555 incident diabetes (3,734 men and 2,821 women) were identified, on average, over 5...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28675237/ursolic-acid-induces-mitochondrial-biogenesis-through-the-activation-of-ampk-and-pgc-1-in-c2c12-myotubes-a-possible-mechanism-underlying-its-beneficial-effect-on-exercise-endurance
#10
Jihang Chen, Hoi Shan Wong, Pou Kuan Leong, Hoi Yan Leung, Wing Man Chan, Kam Ming Ko
Mitochondrial biogenesis, which involves an increase in mitochondrial number and the overall capacity of oxidative phosphorylation, is a critical determinant of skeletal muscle function. Recent findings have shown that some natural products can enhance mitochondrial adaptation to aerobic exercise, which in turn improves exercise performance, presumably by delaying muscle fatigue. Ursolic acid (UA), a natural triterpene, is commonly found in various vegetables and fruits. In the current study, UA was shown to increase mitochondrial mass and ATP generation capacity, with a concomitant production of a low level of mitochondrial reactive oxygen species (ROS) in C2C12 myotubes...
July 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28658301/the-effect-of-anti-rheumatic-medications-for-coronary-artery-diseases-risk-in-patients-with-rheumatoid-arthritis-might-be-changed-over-time-a-nationwide-population-based-cohort-study
#11
Yao-Min Hung, Lichi Lin, Chyong-Mei Chen, Jeng-Yuan Chiou, Yu-Hsun Wang, Paul Yung-Pou Wang, James Cheng-Chung Wei
OBJECTIVES: To determine whether anti-rheumatic drug usage is associated with risk of coronary artery diseases (CAD) in incident Rheumatoid Arthritis (RA) patients. METHODS: Data were obtained from the Taiwan National Health Insurance Research Database. The study cohort comprised 6260 patients who were newly diagnosed with RA between 2001-2010. The study endpoint was occurrence of CAD according to the ICD-9-CM codes. We used the WHO Defined Daily Dose (DDD) as a tool to assess the drugs exposure...
2017: PloS One
https://www.readbyqxmd.com/read/28638297/pediatric-nasal-tip-amputation-successfully-treated-with-nonmicrovascular-replantation-and-hyperbaric-oxygen-therapy
#12
Jason D Pou, H Devon Graham
BACKGROUND: Nasal tip amputation is a rare but difficult problem to manage. Nonmicrovascular nasal tip replantation is a valid and relatively simple repair option for moderate nasal defects, but tissue ischemia and graft failure occur frequently. CASE REPORT: We present the case of a pediatric nasal tip amputation from a dog bite treated with replantation within 5 hours. The 2.5-cm avulsed tip contained skin, cartilage, and mucosa and was replanted as a 3-layer composite graft...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28633916/novel-variant-of-oct4b4-is-differentially-expressed-in-human-embryonic-stem-and-embryonic-carcinoma-cells
#13
Ensieh M Poursani, Majid Mehravar, Bahram Mohammad Soltani, Seyed Javad Mowla
POU domain proteins are an important family of transcription factors that regulates cell type-specific gene expression. One of the most crucial members of this family that maintains pluripotency and self-renewal of embryonic stem cells is POU5F1/OCT4. The OCT4 gene can generate several variants under different situations/cell types includes OCT4A that is the major factor sustains pluripotency in embryonic stem and embryonic carcinoma cells, and also OCT4B and OCT4B1, which might be transcribed from a different potential promoter located in intron1 and are expressed in various tissues and cell types...
June 17, 2017: Gene
https://www.readbyqxmd.com/read/28621470/the-pou-homeodomain-transcription-factor-poum2-and-broad-complex-isoform-2-transcription-factor-induced-by-20-hydroxyecdysone-collaboratively-regulate-vitellogenin-gene-expression-and-egg-formation-in-the-silkworm-bombyx-mori
#14
Y Lin, H Liu, C Yang, J Gu, G Shen, H Zhang, E Chen, C Han, Y Zhang, Y Xu, J Wu, Q Xia
Vitellogenin (Vg) is a source of nutrition for embryo development. Our previous study showed that the silkworm (Bombyx mori) transcription factor broad complex isoform 2 (BmBrC-Z2) regulates gene expression of the Vg gene (BmVg) by induction with 20-hydroxyecdysone (20E). However, the mechanism by which 20E regulates BmVg expression was not clarified. In this study, cell transfection experiments showed that the BmVg promoter containing the POU homeodomain transcription factor POUM2 (POUM2) and BrC-Z2 cis-response elements (CREs) showed a more significant response to 20E than that harbouring only the BrC-Z2 or POUM2 CRE...
June 16, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28600144/targeting-proteins-to-rna-transcription-and-processing-sites-within-the-nucleus
#15
Noemí Sánchez-Hernández, Silvia Prieto-Sánchez, Cristina Moreno-Castro, Juan Pablo Muñoz-Cobo, Younes El Yousfi, Sofía Boyero-Corral, Marc Suñé-Pou, Cristina Hernández-Munain, Carlos Suñé
Studies of the spatial organization of the highly compartmentalized eukaryotic nucleus and dynamics of transcription and RNA processing within it are fundamental for fully understanding how gene expression is regulated in the cell. Although some progress has been made in deciphering the functional consequences of this complex network of interacting molecules in the context of nuclear organization, how proteins and RNA move in the nucleus and how the transcription and RNA processing machineries find their targets are important questions that remain largely unexplored...
June 6, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28586020/altered-expression-of-epithelial-mesenchymal-transition-and-pluripotent-associated-markers-by-sex-steroid-hormones-in-human-embryonic-stem-cells
#16
So-Ye Jeon, Kyung-A Hwang, Cho-Won Kim, Eui-Bae Jeung, Kyung-Chul Choi
Embryonic stem (ES) cells are pluripotent stem cells derived from a developmental stage of pre‑implanted embryos. The present study investigated the effect of female sex steroid hormones on the characteristics of human ES cells by using a feeder‑free culture protocol. In a feeder‑free condition without sex hormones, human ES cells assumed the form of tightly packed cells that grow in a monolayer. The cells had clean and defined edges with no evidence of differentiation and expressed several markers specific for undifferentiated ES cells including POU class 5 homeobox 1 (POU5F1), sex determining region Y‑box 2 (SOX2) and NANOG homeobox (NANOG)...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28577854/diabetes-with-early-kidney-involvement-may-shorten-life-expectancy-by-16-years
#17
Chi Pang Wen, Chia Hsuin Chang, Min Kuang Tsai, June Han Lee, Po Jung Lu, Shan Pou Tsai, Christopher Wen, Chien Hua Chen, Chih Wen Kao, Chwen Keng Tsao, Xifeng Wu
This study aimed to identify the excess risks associated with diabetic patients with early kidney involvement (early diabetic kidney disease). The mortality risks of early diabetic kidney disease, defined as diabetes in early stages 1-3 chronic kidney disease (CKD), were assessed from a cohort of 512,700 adults in Taiwan participating in a health surveillance program from 1994-2008. Three related groups were identified and compared: diabetes without CKD, early diabetic kidney disease, and early CKD without diabetes...
June 1, 2017: Kidney International
https://www.readbyqxmd.com/read/28557428/oxime-based-and-catalyst-free-dynamic-covalent-polyurethanes
#18
Wen-Xing Liu, Chi Zhang, Huan Zhang, Ning Zhao, Zhi-Xiang Yu, Jian Xu
Polyurethanes (PUs) have many applications resulting from their preeminent properties, but being commonly used toxic catalysts, and the lack of processability for PU thermosets cause limitations. Herein, we report a new class of the PU-like dynamic covalent polymers, poly(oxime-urethanes) (POUs), which are prepared from the uncatalyzed polyaddition of multifunctional oximes and hexamethylene diisocyanate (HDI) at ambient temperature. Kinetics studies reveal that almost complete polymerization (∼99% conversion) can be achieved in 3 h at 30 °C in dichloromethane (DCM), the most effective among the solvents evaluated, producing linear POUs with comparable molecular weights to the catalyzed PUs...
June 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28529911/severe-trauma-in-the-geriatric-population
#19
REVIEW
Juan Antonio Llompart-Pou, Jon Pérez-Bárcena, Mario Chico-Fernández, Marcelino Sánchez-Casado, Joan Maria Raurich
Geriatric trauma constitutes an increasingly recognized problem. Aging results in a progressive decline in cellular function which leads to a loose of their capacity to respond to injury. Some medications commonly used in this population can mask or blunt the response to injury. Falls constitute the most common cause of trauma and the leading cause of trauma-related deaths in this population. Falls are complicated by the widespread use of antiplatelets and anticoagulants, especially in patients with brain injury...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28500132/the-zinc-finger-e-box-binding-homeobox-1-zeb1-promotes-the-conversion-of-mouse-fibroblasts-into-functional-neurons
#20
Long Yan, Yue Li, Zixiao Shi, Xiaoyin Lu, Jiao Ma, Baoyang Hu, Jianwei Jiao, Hongmei Wang
The zinc finger E-box-binding transcription factor Zeb1 plays a pivotal role in the epithelial-mesenchymal transition. Numerous studies have focused on the molecular mechanisms by which Zeb1 contributes to this process. However, the functions of Zeb1 beyond the epithelial-mesenchymal transition remain largely elusive. Using a transdifferentiation system to convert mouse embryonic fibroblasts (MEFs) into functional neurons via the neuronal transcription factors achaete-scute family bHLH (basic helix-loop-helix) transcription factor1 (Ascl1), POU class 3 homeobox 2 (POU3F2/Brn2), and neurogenin 2 (Neurog2, Ngn2) (ABN), we found that Zeb1 was up-regulated during the early stages of transdifferentiation...
August 4, 2017: Journal of Biological Chemistry
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