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Pediatric Tuberculosis

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https://www.readbyqxmd.com/read/28229097/pediatric-hypovitaminosis-d-molecular-perspectives-and-clinical-implications
#1
Rafiu Ariganjoye
Vitamin D, a secosteroid, is essential for the development and maintenance of healthy bone in both the adult and pediatric populations. Low level of 25-hydroxy vitamin D (25-(OH)-D) is highly prevalent in children worldwide and has been linked to various adverse health outcomes including rickets, osteomalacia, osteomalacic myopathy, sarcopenia, and weakness, growth retardation, hypocalcemia, seizure and tetany, autism, cardiovascular diseases, diabetes mellitus, cancers (prostate, colon, breast), infectious diseases (viral, tuberculosis), and autoimmune diseases, such as multiple sclerosis and Hashimoto's thyroiditis...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28192579/infectious-diseases-and-immunizations-in-international-adoption
#2
Emily Obringer, Linda Walsh
Children who are adopted internationally have an increased risk of infectious diseases due to endemic conditions and variable access to preventive health care, such as vaccines, in their country of origin. Pediatricians and other providers who care for children should be familiar with the recommended screening for newly arrived international adoptees. Testing for gastrointestinal pathogens, tuberculosis, hepatitis, syphilis, and HIV should be routinely performed. Other endemic diseases and common skin infections may need to be assessed...
February 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28192578/when-the-great-masquerader-reveals-itself-tuberculosis
#3
Brittany Hodgson, Benjamin D Kornfeld, Bridget M Wild
Pneumonia is a clinical diagnosis often treated empirically and successfully on an outpatient basis. When a patient fails to improve, the clinician is left to revisit the differential of pathogens and reconsider the host. Admission, imaging, and invasive and noninvasive testing are part of the toolkit for the severe or atypical case of pneumonia. For fastidious organisms, achieving a culture-proven diagnosis can be quite difficult. This article discusses the screening and testing for tuberculosis, reviews the utility of computed tomography imaging and bronchoscopy with bronchoalveolar lavage in severe or atypical pneumonia, and highlights the barriers to definitive diagnosis even when the causative microbe is on the differential diagnosis when a patient is admitted...
February 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28188122/drug-resistance-detection-and-mutation-patterns-of-multidrug-resistant-tuberculosis-strains-from-children-in-delhi
#4
Jyoti Arora, Ritu Singhal, Manpreet Bhalla, Ajoy Verma, Niti Singh, Digamber Behera, Rohit Sarin, Vithal Prasad Myneedu
A total of 312 sputum samples from pediatric patients presumptive of multidrug resistant tuberculosis were tested for the detection of drug resistance using the GenoTypeMTBDRplus assay. A total of 193 (61.8%) patients were smear positive and 119 (38.1%) were smear negative by Ziehl-Neelsen staining. A line probe assay was performed for 208 samples/cultures (193 smear positive samples and 15 cultures from smear negative samples). Valid results were obtained from 198 tests. Some 125/198 (63.1%) were sensitive to both rifampicin (RIF) and isoniazid (INH), while 73/198 (36...
February 7, 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28164036/primary-extrapulmonary-multidrug-resistant-tuberculosis-in-an-immunocompetent-child-presenting-with-pleural-effusion
#5
Sankalp Yadav, Gautam Rawal
The developing countries are having a number of public health issues. The situation in these resource-limited countries is scary due to the huge burden of infectious diseases like tuberculosis (TB). The latest reports from the WHO shows a high number of drug resistant cases even in the pediatric age groups. Also, the lack of suspicion of drug resistant TB (DR-TB) in the pediatric cases, especially in the absence of a past or family history may lead to delay in diagnosis and flaring-up of the disease. We herein present the very first case of the primary multidrug-resistant TB in an HIV negative child who presented with the left sided pleural effusion...
January 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28163438/a-rare-case-of-cardiac-tumor-in-a-child
#6
Mallar Mukharjee, Jigna N Bathia, Apurba Ghosh, Anil Kumar Singhi
Pediatric cardiac tumors are rare and usually benign. An infectious etiology like tuberculosis invading myocardium and presenting as infiltrative mass is extremely rare. We present a case of a 15 month old girl with clinical feature of cardiac failure who had infiltrative multiple myocardial masses in echocardiogram. Advanced cardiac imaging by Cardiac Magnetic resonance imaging (MRI) helped in tissue delineation. Therapeutic trial of anti-tubercular drugs in view clinical suspicion of Tuberculosis resulted in complete remission of symptom and disappearance of the cardiac mass...
January 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28160362/globalization-of-pediatric-transplantation-the-risk-of-tuberculosis-or-not-tuberculosis
#7
Mignon McCulloch, Philana Ling Lin
The risk of TB among pediatric SOT recipients increases as the globalization of medical care continues to broaden. Unlike adults, children and especially infants are more susceptible to TB as a complication after transplantation. Little data exist regarding the true incidence of TB and the optimal risk-based management of this very vulnerable population. Here, we highlight the theoretical and practical issues that complicate the management of these patients and pose some questions that should be addressed when managing these patients...
February 3, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28157463/use-of-antiretrovirals-in-hiv-infected-children-in-a-tuberculosis-prevention-trial-impaact-p1041
#8
B Zeldow, S Kim, G McSherry, M F Cotton, P Jean-Philippe, A Violari, R Bobat, S Nachman, L M Mofenson, S A Madhi, C Mitchell
SETTING: International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1041, a tuberculosis (TB) prevention trial conducted among children enrolled from 2004 to 2008 during South Africa's roll-out of combination antiretroviral therapy (ART). OBJECTIVE: To estimate TB incidence and mortality and the effect of ART. DESIGN: Children were pre-screened to exclude TB disease and exposure, actively screened 3-monthly for TB exposure and symptoms, and provided post-exposure isoniazid prophylaxis therapy (IPT)...
January 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28146598/adherence-to-latent-tuberculosis-infection-treatment-in-a-population-with-a-high-number-of-refugee-children
#9
Tanya Rogo, Cynthia Eleanya, Priya Hirway, Doreen Pelland, Carol Lewis, Penelope Dennehy, Phyllis Losikoff
BACKGROUND: Refugee populations in the US have a higher reported prevalence of latent tuberculosis infection (LTBI). The objective of this study was to assess adherence to LTBI treatment in refugee and non-refugee children living in Rhode Island. METHODS: This was a retrospective review of LTBI patients seen in the Hasbro Pediatric Tuberculosis Clinic between August 2009 and September 2011. RESULTS: Of 120 patients with LTBI, 93% were foreign-born and 30% were refugees...
February 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28134745/the-risk-of-m-tuberculosis-transmission-from-pediatric-index-cases-to-school-pupils
#10
Paola Piccini, Elisabetta Venturini, Leila Bianchi, Simonetta Baretti, Paolo Filidei, Luana Paliaga, Franca Mazzoli, Elena Chiappini, Maurizio de Martino, Luisa Galli
This study is the largest report on M. tuberculosis transmission rate (TR) from children with pulmonary tuberculosis to school pupils. Higher TR (around 21.6%) was observed in contacts of smear-positive children. TR from pediatric smear-negative index cases was around 0. If our data are confirmed, school contacts of a smear-negative index case could be screened only by clinical evaluation and TST, avoiding routine use of chest radiographs in children less than 5 years of age as well.
January 26, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28129755/improving-case-detection-of-tuberculosis-among-children-in-bangladesh-lessons-learned-through-an-implementation-research
#11
Ziaul Islam, Kazi Istiaque Sanin, Tahmeed Ahmed
BACKGROUND: According to the Bangladesh National Tuberculosis Control Program (NTP), the proportion of childhood tuberculosis (TB) among all reported cases is only 3%. This is considerably lower compared to other high-burden countries. One of our previous studies identified substantial gaps at the primary care level related to capacity of service providers, supply of required logistics and community awareness about childhood TB. Therefore, we conducted an implementation study with the objectives to address those gaps...
January 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28102654/tuberculosis-and-tuberculin-skin-test-reactivity-in-pediatric-patients-with-celiac-disease
#12
Nafiye Urganci, Derya Kalyoncu
BACKGROUND: The aim of the study was to determine tuberculin skin test reactivity and associated factors in pediatric patients with celiac disease (CD). METHODS: Tuberculin skin test (TST) was performed on 28 patients with CD aged from 1 year to 15 years (mean, 6.64±4.8) and 28 healthy age and sex-matched children. The association between TST reactivity and parameters such as age, gender, malnutrition, clinical presentation, compliance to gluten free diet and response to hepatitis A and B vaccinations were determined...
February 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28060119/acquired-tef-in-hodgkin-lymphoma-in-a-child-a-rare-clinical-association
#13
Vinay Munikoty, Anmol Bhatia, Deepak Bansal, Ashim Das, Niranjan Khandelwal
BACKGROUND: Malignancy is the most common etiology of acquired fistulae between the tracheobronchial tree and esophagus. The majority are due to either primary bronchial or esophageal carcinoma, and are typically observed in adult population. The occurrence of tracheoesophageal fistula (TEF) in patients with Hodgkin lymphoma is a rare phenomenon. OBSERVATION: We report a rare case of Hodgkin lymphoma with TEF in a 10-year-old girl at presentation. She also developed pulmonary tuberculosis later during the follow up...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28053917/mortality-among-pulmonary-tuberculosis-and-hiv-1-co-infected-nigerian-children-being-treated-for-pulmonary-tuberculosis-and-on-antiretroviral-therapy-a-retrospective-cohort-study
#14
Augustine O Ebonyi, Stephen Oguche, Oche O Agbaji, Atiene S Sagay, Prosper I Okonkwo, John A Idoko, Phyllis J Kanki
BACKGROUND: Mortality data, including the risk factors for mortality in HIV-infected children with pulmonary TB (PTB) being treated for PTB and who are on antiretroviral therapy (ART), are scarce in Nigeria. We determined the mortality rate and risk factors for mortality among such children, at the pediatric HIV clinic of the Jos University Teaching Hospital (JUTH) in Jos, Nigeria. METHODS: We performed a retrospective cohort study on 260 PTB-HIV-1 co-infected children, aged 2 months to 13 years, being treated for PTB and on ART from July 2005 to March 2013...
2016: Germs
https://www.readbyqxmd.com/read/28053376/vitamin-d-deficiency-among-pediatric-osteoarticular-tuberculosis-patients
#15
Pradeep Kumar Dabla, Anil Agarwal, Madhusudan Mishra, Shikha Sharma
OBJECTIVES: We prospectively investigated serum 25 hydroxy vitamin D concentrations in children suffering from osteoarticular tuberculosis. The age or sex correlation to vitamin D levels in affected subjects was also calculated. METHODS: Twenty five untreated children with osteoarticular tuberculosis were taken as cases along with equal number of age and sex matched 'healthy' controls. The following laboratory references for defining the vitamin D status were used (<30 nmol/L = deficiency; 30-75 nmol/L = insufficiency; > 75 nmol/L = sufficiency)...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28043630/effective-testing-for-pulmonary-tuberculosis-using-xpert-mtb-rif-assay-for-stool-specimens-in-immunocompetent-pakistani-children
#16
Zahra Hasan, Fehmina Arif, Sadia Shakoor, Aisha Mehnaz, Alnoor Akber, Akbar Kanji, Mussarat Ashraf, Rumina Hasan
OBJECTIVE/BACKGROUND: Childhood tuberculosis (TB) is largely a paucibacillary disease and difficult to diagnose. It is difficult to obtain a sputum or gastric aspirate (GA) sample, and patients are often undiagnosed and treated empirically. Stool is a noninvasive specimen not usually used for TB testing in Pakistan. We investigated the value of Xpert MTB/RIF to diagnose Mycobacterium tuberculosis (MTB) in children with pulmonary TB cases, by performing comparative testing of GA and stool samples...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043582/mediastinal-lymphadenopathy-in-pediatric-tuberculosis-in-computed-tomography-scan
#17
Payam Mehrain, Amin Momeni Moghaddam, Elham Tavakol, Afshin Amini, Mehrdad Moghimi, Ali Kabir, Ali Akbar Velayati
BACKGROUND/OBJECTIVES: Pediatric tuberculosis is usually a primary infection presenting mainly as mediastinal or hilar adenopathy in computed tomography (CT) scan. In this study, we study the distribution and other CT scan characteristics of mediastinal lymphadenopathy in childhood tuberculosis. METHODS: Chest CT scans of 75 cases of pediatric tuberculosis at Masih Daneshvari Hospital in Tehran, Iran, from 2009 to 2013 were studied regarding characteristics of mediastinal lymphadenopathy...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043580/application-of-highly-portable-minion-nanopore-sequencing-technology-for-the-monitoring-of-nosocomial-tuberculosis-infection
#18
Matthew Bates, Pascal Polepole, Nathan Kapata, Matt Loose, Justin O'Grady
Referral hospitals in sub-Saharan Africa concentrate large numbers of tuberculosis (TB) and multidrug-resistant TB (MDR-TB) patients, failed by community TB services. We have previously shown, from enhanced screening and through autopsy studies, a significant burden of missed TB infections at the University Teaching Hospital, Lusaka, Zambia, with many patients dying or being discharged without treatment. With minimal TB isolation facilities and minimal political will to invest in broader screening and isolation, the risk of nosocomial transmission is likely to be extremely high...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043528/childhood-tuberculosis-in-qatar
#19
Jay P N Singh, Reem Mohammed, Thanveer Thayyullathil, Abdullatif Al-Khal, Zubaida Al-Suwaidi
Childhood tuberculosis (TB) has been long neglected but has gained attention in recent years. In 2012, the World Health Organization annual report included an estimate for childhood TB for the first time, and in the following year, the TB Alliance received a grant from UNITAID (International Drug Purchase Facility) to develop pediatric TB formulations. Qatar is a low-incidence country. In this observational study, laboratory-confirmed cases of TB were analyzed from 2013 to 2015 and included patients aged ⩽14years...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043488/development-of-the-food-supplement-nyaditum-resae-as-a-new-tool-to-reduce-the-risk-of-tuberculosis-development
#20
Nestani Tukvadze, Paula Cardona, Sergo Vashakidze, Natalia Shubladze, Zaza Avaliani, Cris Vilaplana, Pere-Joan Cardona
Nyaditum resae (NR) is a galenic preparation of heat-killed Mycobacterium manresensis (hkMn). This is a new species that belongs to the Mycobacterium fortuitum complex, and it is present in drinking water-thus, regulatorily speaking, it is considered a food supplement. Preclinical studies in the murine model of active tuberculosis (TB) in the C3HeB/FeJ strain have demonstrated that daily administration of NR containing 10(3)-10(6)hkMn for 14days was able to stop the progression toward active TB [1]. The mechanism of action was linked to the induction of low dose tolerance and was related to the increase of Tuberculin Purified Protein Derivative (PPD) memory-specific Tregs (CD4(+)CD25(+)CD39(+) cells) after ex vivo incubation of splenocytes for 7days...
December 2016: International Journal of Mycobacteriology
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