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https://www.readbyqxmd.com/read/29793167/improvement-of-neuronal-differentiation-by-carbon-monoxide-role-of-pentose-phosphate-pathway
#1
Ana S Almeida, Nuno L Soares, Catarina O Sequeira, Sofia A Pereira, Ursula Sonnewald, Helena L A Vieira
Over the last decades, the silent-killer carbon monoxide (CO) has been shown to also be an endogenous cytoprotective molecule able to inhibit cell death and modulate mitochondrial metabolism. Neuronal metabolism is mostly oxidative and neurons also use glucose for maintaining their anti-oxidant status by generation of reduced glutathione (GSH) via the pentose-phosphate pathway (PPP). It is established that neuronal differentiation depends on reactive oxygen species (ROS) generation and signalling, however there is a lack of information about modulation of the PPP during adult neurogenesis...
May 15, 2018: Redox Biology
https://www.readbyqxmd.com/read/29793080/visualizing-the-shape-of-society-an-analysis-of-public-bads-and-burden-allocation-due-to-household-consumption-using-an-input-output-approach
#2
Andrew Chapman, Yosuke Shigetomi
This study investigates how our lifestyles can cause societal issue including a reduction in social equity due to the consumption of natural resources. Based on a range of household environmental footprints and their application to a quantitative social equity evaluation framework, a methodology is proposed which identifies the creation and origin of public bads within society. This research builds on the methodologies of energy policy sustainability evaluation incorporated with environmentally extended input output analysis in order to critically assess lifestyle-based consumption impacts, and to quantify the allocation of subsequent burdens across generations...
May 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29793032/phosphorylated-and-non-phosphorylated-hck-kinase-domains-produced-by-cell-free-protein-expression
#3
Kazushige Katsura, Yuri Tomabechi, Takayoshi Matsuda, Mayumi Yonemochi, Junko Mikuni, Noboru Ohsawa, Takaho Terada, Shigeyuki Yokoyama, Mutsuko Kukimoto-Niino, Chie Takemoto, Mikako Shirouzu
Since phosphorylation is involved in various physiological events, kinases and interacting factors can be potential targets for drug discovery. For the development and improvement of inhibitors from the point of view of mechanistic enzymology, a cell-free protein synthesis system would be advantageous, since it could prepare mutant proteins easily. However, especially in the case of protein kinase, product solubility remains one of the major challenges. To overcome this problem, we prepared a chaperone-supplemented extract from Escherichia coli BL21 cells harboring a plasmid encoding a set of chaperone genes, dnaK, dnaJ, and grpE...
May 21, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29792995/lumbar-discectomy-is-associated-with-higher-rates-of-lumbar-fusion
#4
Hector Castillo, Ravi Chintapalli, Harout Boyajian, Sebastian A Cruz, Vince K Morgan, Lewis L Shi, Michael J Lee
BACKGROUND CONTEXT: Lumbar disc herniation affects over three million people in the United States every year, and the rate of operation continually increases, particularly in patients 60 years or older.1,2 Surgical discectomy is a common treatment for lumbar disc herniation.1,3 One concern for this method is the risk of undergoing additional surgeries. 2,5,7 There are very limited population-level studies that examine the rate of lumbar fusion following lumbar discectomy. Additionally, there is no study that examines the risk of undergoing lumbar fusion in patients who have undergone lumbar discectomies compared to the risk of lumbar fusion in the general population with no previous lumbar discectomy...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792927/bacillus-subtilis-as-probiotic-candidate-for-red-sea-bream-growth-performance-oxidative-status-and-immune-response-traits
#5
Amr I Zaineldin, Sayed Hegazi, Shunsuke Koshio, Manabu Ishikawa, Abdulnasser Bakr, Abeer M S El-Keredy, Mahmoud A O Dawood, Serge Dossou, Weilong Wang, Zhang Yukun
The effects of dietary administration of Bacillus subtilis on the growth, digestive enzyme activity, blood chemistry, oxidative status and immune response of red sea bream (Pagrus major) were evaluated in the current study. Fish fed five different levels of B. subtilis at 0 (BS0), 1 × 104 (BS1), 1 × 106 (BS2), 1 × 108 (BS3) and 1 × 1010 (BS4) CFU kg-1 diet for 60 days. The obtained results showed that B. subtilis supplementation significantly improved growth performance (FBW, WG and SGR), feed utilization (FI, FCE, PER and PG) and whole-body protein content when compared to the control group (P < 0...
May 21, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29792885/effects-of-vasopressin-on-neural-processing-of-infant-crying-in-expectant-fathers
#6
Sandra Thijssen, Anna E Van 't Veer, Jurriaan Witteman, Willemijn M Meijer, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg
In a randomized, double blind, placebo-controlled, within-subject magnetic resonance imaging study, we examined the effect of 20 IU intranasal vasopressin on the neural processing of infant crying in 25 fathers-to-be. We explored whether familial background modulates vasopressin effects, and whether vasopressin differentially affects cry processing coupled with neutral or emotional contextual information. Participants listened to cries accompanied by neutral ('this is an infant') or emotional ('this infant is sick/bored') contextual information, and neutral control sounds ('this is a saw')...
May 21, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29792782/25-hydroxyvitamin-d3-and-1-25-dihydroxyvitamin-d3-as-an-antiviral-and-immunomodulator-against-herpes-simplex-virus-1-infection-in-hela-cells
#7
Archit Kumar, Mini P Singh, Ragini S Kumar, Radha Kanta Ratho
The antiviral and immunomodulatory role of vitamin D has been shown in various viral infections. However, there is scanty literature available about the effect of vitamin D supplementation in herpes simplex virus-1 (HSV-1) infection. Therefore, the present study aimed to evaluate the role of two different forms of vitamin D: 25-hydroxyvitamin D3 (25D3) and 1,25-dihydroxyvitamin D3 (1,25D3) against HSV-1 in HeLa cells. The HeLa cells were supplemented with either 25D3 or 1,25D3 before HSV-1 infection and were studied after 6, 12, and 24 h postinfection (p...
May 24, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29792778/does-iron-supplementation-improve-performance-in-iron-deficient-nonanemic-athletes
#8
Amity Rubeor, Carmen Goojha, Jeffrey Manning, Jordan White
CONTEXT: Supplementing iron-deficient nonanemic (IDNA) athletes with iron to improve performance is a trend in endurance sports. OBJECTIVES: To investigate the benefits of iron on performance, identify a ferritin level cutoff in IDNA athletes, and determine which iron supplementation regimens are most effective. DATA SOURCES: A search of the PubMed, CINAHL, Embase, ERIC, and Cochrane databases was performed in 2014 including all articles. Citations of pertinent review articles were also searched...
May 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29792544/synergistic-phytochemicals-fail-to-protect-against-ovariectomy-induced-bone-loss-in-rats
#9
Suresh Ambati, Colette N Miller, Erica F Bass, Natalie M Hohos, Diane L Hartzell, Emily W Kelso, Emily R Trunnell, Jeong-Yeh Yang, Mary Anne Della-Fera, Clifton A Baile, Srujana Rayalam
Menopause induces a loss of bone as a result of estrogen deficiency. Despite pharmaceutical options for the treatment of osteopenia and osteoporosis, many aging women use dietary supplements with estrogenic activity to prevent bone loss and other menopausal-related symptoms. Such supplements are yet to be tested for efficacy against a Food and Drug Administration (FDA) approved medication for menopausal bone loss such as zoledronic acid (ZA). The postmenopausal rat model was used to investigate the efficacy of various synergistic phytochemical blends mixed into the diet for 16 weeks...
May 24, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29792369/gene-delivery-in-the-cornea-in-vitro-ex-vivo-evaluation-of-solid-lipid-nanoparticle-based-vectors
#10
Mónica Vicente-Pascual, Andrea Albano, María Á Solinís, Loredana Serpe, Alicia Rodríguez-Gascón, Federica Foglietta, Elisabetta Muntoni, Josune Torrecilla, Ana Del Pozo-Rodríguez, Luigi Battaglia
AIM: Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea. RESULTS: In vitro, vectors showed suitable features as nonviral vectors (size, ζ-potential, DNA binding, protection and release), and they were able to enter and transfect human corneal epithelial cells...
May 24, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29792366/nutritional-characterisation-of-zambian-moringa-oleifera-acceptability-and-safety-of-short-term-daily-supplementation-in-a-group-of-malnourished-girls
#11
Michela Barichella, Gianni Pezzoli, Samanta A Faierman, Benedetta Raspini, Martina Rimoldi, Erica Cassani, Simona Bertoli, Alberto Battezzati, Alessandro Leone, Laura Iorio, Valentina Ferri, Giovanna Pinelli, Chiara Pusani, Carlotta Bolliri, Roberto Cilia, Serena Caronni, Patrizia De Marco, Emanuele Cereda
In Zambia, chronic malnutrition still is one of the most common problem among children. To fight against malnutrition, the easiest short-term solution could be to combine specific types of food with affordable local plants. A large variety of natural food resources grow in Zambia, such as Moringa oleifera (MO), whose leaves are known for their health benefits, but are not consumed much by local populations. We analysed Zambian MO powder obtained from dried leaves and found that it contains large amounts of protein, minerals and vitamins, such as iron, calcium and carotenoids...
May 24, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29792085/role-of-selenium-supplementation-in-prevention-of-late-onset-sepsis-among-very-low-birth-weight-neonates-a-systematic-review-of-randomized-controlled-trials
#12
Bhawan Garg, Anju Bansal, Nandkishor Kabra
BACKGROUND: Neonatal sepsis is one of the most common cause of neonatal morbidity and mortality. Selenium has antioxidant and immune-modulating properties. AIM: The aim of this systematic review is to evaluate role of selenium supplementation in the prevention of late onset sepsis (LOS) among very low birth weight (VLBW) neonates. METHODS: We searched literature for this review by searching the Cochrane Central Register of Controlled Trials (CENTRAL) electronic PubMed, Embase and Google Scholar...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29791915/costaria-costata-extract-suppresses-development-of-atopic-dermatitis-in-chloro-2-4-dinitrobenzene-treated-nc-nga-mice
#13
Ok-Kyung Kim, Minhee Lee, Han Ol Kwon, Dasom Lee, Jeongjin Park, Eungpil Kim, Yanghee You, Young Tae Lim, Woojin Jun, Jeongmin Lee
We investigated the potential effects of Costaria costata (CC) on atopic dermatitis (AD) development in chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. CC is a brown alga distributed across the seas of Korea, China, and Japan. A total of 40 mice were randomly assigned to 5 groups with 8 mice per group: untreated Balb/c mice, AD control (0.1% w/v DNCB-treated NC/Nga mice), positive control (i.e., DNCB-treated NC/Nga mice fed a dietary supplement of 66.6 mg/kg of body weight [b.w.] of CJLP133), DNCB-treated NC/Nga mice fed a dietary supplement of 100 mg/kg b...
May 23, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29791909/iodine-induced-fetal-hypothyroidism-diagnosis-and-treatment-with-intra-amniotic-levothyroxine
#14
Macy T Hardley, Andrew H Chon, Jorge Mestman, Caroline T Nguyen, Mitchell E Geffner, Ramen H Chmait
BACKGROUND: Iodine is necessary for fetal thyroid development. Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. CASE REPORT: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. The fetus was successfully treated with intra-amniotic levothyroxine injections. Serial fetal blood sampling confirmed fetal escape from the Wolff-Chaikoff effect in the mid third trimester...
May 23, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29791786/matrine-suppresses-kras-driven-pancreatic-cancer-growth-by-inhibiting-autophagy-mediated-energy-metabolism
#15
Young-Ra Cho, Ji Hyeon Lee, Ji Hye Kim, So-Yeon Lee, Suna Yoo, Min-Kyo Jung, Su Jung Kim, Hyun Ju Yoo, Chang-Gi Pack, Jin Kyung Rho, Jaekyoung Son
Matrine is a natural compound extracted from the herb Sophora flavescens Ait which is widely used in traditional Chinese medicine for treating various diseases. Recently, matrine was reported to have antitumor effects against a variety of cancers without any obvious side effects; however, the molecular mechanisms of its antiproliferative effects on cancer are unclear. Here, we report that matrine inhibits autophagy-mediated energy metabolism, which is necessary for pancreatic cancer growth. We found that matrine significantly reduces pancreatic cancer growth in vitro and in vivo by insufficiently maintaining mitochondrial metabolic function and energy level...
May 23, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29791675/development-of-a-diet-quality-index-adapted-for-pregnant-women
#16
Lívia Castro Crivellenti, Daniela Cristina Candelas Zuccolotto, Daniela Saes Sartorelli
OBJECTIVE: To develop a Diet Quality Index Adapted for Pregnant Women (IQDAG) and to evaluate its relation with the characteristics of women treated at the Brazilian Unified Health System. METHODS: The data on food intake come from a cross-sectional study carried out with 785 adult pregnant women in the city of Ribeirão Preto, state of São Paulo, Brazil, between 2011 and 2012. The index was based on the recommendations of the Brazilian Ministry of Health, previous national dietary indexes, and the new Dietary Guidelines for the Brazilian Population...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29791620/intervention-time-until-discharge-for-newborns-on-transition-from-gavage-to-exclusive-oral-feeding
#17
Andréa Monteiro Correia Medeiros, Blenda Karen Batista Ramos, Déborah Letticia Santana Santos Bomfim, Conceição Lima Alvelos, Talita Cardoso da Silva, Ikaro Daniel de Carvalho Barreto, Felipe Batista Santos, Ricardo Queiroz Gurgel
Purpose Measure the intervention time required for transition from gavage to exclusive oral feeding, comparing newborns exposed exclusively to the mother's breast with those who, in addition to breastfeeding, received supplementation using a cup or baby bottle. Methods Analytical, longitudinal, cohort study conducted with 165 newborns (NB) divided into groups according to severity of medical complications (G1-with no complications; G2-with significant complications), and into subgroups according to feeding mechanism (A and B)...
2018: CoDAS
https://www.readbyqxmd.com/read/29791509/health-outcomes-and-adherence-to-a-healthy-lifestyle-after-a-multimodal-intervention-in-people-with-multiple-sclerosis-three-year-follow-up
#18
Claudia H Marck, Alysha M De Livera, Chelsea R Brown, Sandra L Neate, Keryn L Taylor, Tracey J Weiland, Emily J Hadgkiss, George A Jelinek
BACKGROUND: Modifiable risk factors such as smoking and sedentary lifestyle adversely affect multiple sclerosis (MS) progression. Few multimodal behavioural interventions have been conducted for people with MS, and follow-up beyond 1 year is rare for lifestyle interventions. This study assessed adoption and adherence to healthy lifestyle behaviours and health outcomes 3 years after a lifestyle modification intervention, using generalized estimating equation models to account for within-participant correlation over time...
2018: PloS One
https://www.readbyqxmd.com/read/29791433/the-belfast-youth-development-study-byds-a-prospective-cohort-study-of-the-initiation-persistence-and-desistance-of-substance-use-from-adolescence-to-adulthood-in-northern-ireland
#19
Kathryn Higgins, Aisling McLaughlin, Oliver Perra, Claire McCartan, Mark McCann, Andrew Percy, Julie-Ann Jordan
BACKGROUND: Substance misuse persists as a major public health issue worldwide with significant costs for society. The development of interventions requires methodologically sound studies to explore substance misuse causes and consequences. This Cohort description paper outlines the design of the Belfast Youth Development (BYDS), one of the largest cohort studies of its kind in the UK. The study was established to address the need for a long-term prospective cohort study to investigate the initiation, persistence and desistance of substance use, alongside life course processes in adolescence and adulthood...
2018: PloS One
https://www.readbyqxmd.com/read/29791066/application-of-denaturing-capillary-electrophoresis-for-the-detection-of-prognostic-mutations-in-isocitrate-dehydrogenase-1-and-isocitrate-dehydrogenase-2-genes-in-brain-tumors
#20
Lucie Benesova, Barbora Belsanova, Filip Kramar, Tereza Halkova, Vladimir Benes, Marek Minarik
Malignant transformation in gliomas is frequently supplemented by somatic mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 genes. It has recently emerged that mutations in these genes are associated with prolonged survival and should be used as prognostic factor in management of brain cancer patients. There are several approaches in use for the detection of isocitrate dehydrogenase 1 and 2 mutations, however, these often exhibit shortcomings such as convoluted protocols with long processing time, complex (and costly) dedicated fluorescent probes and/or high demand on amounts of input DNA...
May 23, 2018: Journal of Separation Science
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