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Freezing of speech

Matej Skorvanek, Pablo Martinez-Martin, Norbert Kovacs, Ivan Zezula, Mayela Rodriguez-Violante, Jean-Christophe Corvol, Pille Taba, Klaus Seppi, Oleg Levin, Anette Schrag, Iciar Aviles-Olmos, Mario Alvarez-Sanchez, Tomoko Arakaki, Zsuzsanna Aschermann, Eve Benchetrit, Charline Benoit, Alberto Bergareche-Yarza, Amin Cervantes-Arriaga, Anabel Chade, Florence Cormier, Veronika Datieva, David A Gallagher, Nelida Garretto, Zuzana Gdovinova, Oscar Gershanik, Milan Grofik, Vladimir Han, Liis Kadastik-Eerme, Monica M Kurtis, Graziella Mangone, Juan Carlos Martinez-Castrillo, Amelia Mendoza-Rodriguez, Michal Minar, Henry P Moore, Mari Muldmaa, Christoph Mueller, Bernadette Pinter, Werner Poewe, Karin Rallmann, Eva Reiter, Carmen Rodriguez-Blazquez, Carlos Singer, Peter Valkovic, Christopher G Goetz, Glenn T Stebbins
BACKGROUND: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. METHODS: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression...
March 28, 2018: Parkinsonism & related Disorders
Fabian Blasberg, Lars Wojtecki, Saskia Elben, Philipp Jörg Slotty, Jan Vesper, Alfons Schnitzler, Stefan Jun Groiss
BACKGROUND: Deep brain stimulation (DBS) surgery for Parkinson's disease (PD) is usually performed as awake surgery allowing sufficient intraoperative testing. Recently, outcomes after asleep surgery have been assumed comparable. However, direct comparisons between awake and asleep surgery are scarce. OBJECTIVE: To investigate the difference between awake and asleep surgery comparing motor and nonmotor outcome after subthalamic nucleus (STN)-DBS in a large single center PD population...
March 13, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Didde Trærup Schnack, Katalin Kiss, Søren Hansen, Hidemi Miyazaki, Birgitte Bech, Per Caye Thomasen
Sporadic endolymphatic sac tumor is a very rare neoplasm. It is low malignant, locally destructive and expansive, but non-metastasizing. The tumor is very rare in the sporadic form, but more often associated with Von Hippel-Lindau disease. A 65-year old man with left sided tinnitus and hearing loss for several months. Audiometry showed an asymmetrical sensory neural hearing loss on the left side up to 60 dB. The speech discrimination score was 46% and stapedial reflexes were absent. Several years earlier, he had suffered from periods of dizziness...
August 2017: Journal of International Advanced Otology
Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman, Peter Warnke
Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on improving freezing of gait (FOG) and other axial symptoms, including speech and swallowing function, in Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN DBS). However, other studies failed to confirm this. It seems not clear what determines the difference in response to LFS...
2017: Translational Neurodegeneration
Mitsuaki Ishii, Hideaki Mashimo
[Purpose] In patients with parkinsonism, the precise mechanism of impaired voluntary cough remains poorly understood. This study used the flow-volume curve to clarify whether disordered voluntary cough reflects the freezing phenomenon. [Subjects and Methods] Case 1 was a 58-year-old female who had been suffering from progressive supranuclear palsy-pure akinesia with gait freezing. Case 2 was a 59-year-old female who had advanced juvenile parkinsonism. The subjects were asked to take a deep inspiration to the total lung capacity and then cough more than five times through the face mask into the spirometer without intervening inspirations between the coughing efforts...
March 2017: Journal of Physical Therapy Science
Jean-Jacques Lemaire, Bruno Pereira, Philippe Derost, François Vassal, Miguel Ulla, Dominique Morand, Guillaume Coll, Jean Gabrillargues, Ana Marques, Bérangère Debilly, Jérôme Coste, Franck Durif
BACKGROUND: Deep brain stimulation (DBS) in Parkinson's disease uses bi-hemispheric high-frequency stimulation within the subthalamus, however, the specific impacts of bilaterality of DBS are still not clear. Thus, we aimed to study the individual-level clinical impact of locations of right-left contact pair-up accounting for each subthalamic nucleus (STN) anatomy. METHODS: Contact locations and effects at 1 year were studied retrospectively in an unselected series of 53 patients operated between 2004 and 2010...
2016: Surgical Neurology International
Sangwon Han, Minyoung Oh, Jungsu S Oh, Sang Ju Lee, Seung Jun Oh, Sun Ju Chung, Hee Kyung Park, Jae Seung Kim
Importance: Pure akinesia with gait freezing (PAGF) is a clinical syndrome characterized by freezing of gait, handwriting, and speech without abnormal eye movement or cognitive impairment. Several studies have suggested that PAGF may be a variant of progressive supranuclear palsy (PSP). However, the characteristics of striatal dopamine transporter loss in PAGF are unknown. Objective: To investigate the subregional pattern of striatal dopamine transporter loss in patients with PAGF in comparison with patients with PSP and those with Parkinson disease (PD)...
December 1, 2016: JAMA Neurology
Ju Young Shin, Ryan T Pohlig, Barbara Habermann
Parkinson's disease (PD) is a neurodegenerative disease with a wide range of symptom presentations. The purpose of this research was to compare self-reported motor and non-motor symptoms of PD by sex and disease duration. This study was a cross-sectional descriptive survey in community-dwelling people with PD. A total of 141 participants (64.6% response rate; 59.6% men; Mage = 69.7 years) were included. Males reported more rigidity, speech problems, sexual dysfunction, memory problems, and socializing problems than females...
November 2017: Western Journal of Nursing Research
Mehmet Karakoc, Mehmet Ilker Yon, Gul Yalcin Cakmakli, Ersin Kasim Ulusoy, Aydin Gulunay, Nese Oztekin, Fikri Ak
We aimed to investigate the association between drooling and possible etiological factors in Parkinson's disease (PD) and to determine its effect on the quality of life. Demographic data of the 63 patients with idiopathic PD were recorded. Radboud Oral Motor Inventory for Parkinson's disease (ROMP) test was administered to all patients to evaluate speech, swallowing functions, and saliva control. The freezing of gait questionnaire (FOGQ) was used to evaluate gait and freezing of gait. Dynamic Parkinson gait scale (DYPAGS) was administered for the objective quantification of PD gait features...
December 2016: Neurological Sciences
Lucia Ricciardi, Michela Ebreo, Adriana Graziosi, Marianna Barbuto, Chiara Sorbera, Letterio Morgante, Francesca Morgante
INTRODUCTION: Speech disturbances in Parkinson's disease (PD) are heterogeneous, ranging from hypokinetic to hyperkinetic types. Repetitive speech disorder has been demonstrated in more advanced disease stages and has been considered the speech equivalent of freezing of gait (FOG). We aimed to verify a possible relationship between speech and FOG in patients with PD. METHODS: Forty-three consecutive PD patients and 20 healthy control subjects underwent standardized speech evaluation using the Italian version of the Dysarthria Profile (DP), for its motor component, and subsets of the Battery for the Analysis of the Aphasic Deficit (BADA), for its procedural component...
November 2016: Parkinsonism & related Disorders
José Fidel Baizabal-Carvallo, Marlene Alonso-Juarez
INTRODUCTION: Traditionally, deep brain stimulation (DBS) for movement disorders (MDs) is provided using stimulation frequencies equal to or above 100 Hz. However, recent evidence suggests that relatively low-frequency stimulation (LFS) below 100 Hz is an option to treat some patients with MDs. OBJECTIVES: We aimed to review the clinical and pathophysiological evidence supporting the use of stimulation frequencies below 100 Hz in different MDs. RESULTS: Stimulation of the subthalamic nucleus at 60 Hz has provided benefit in gait and other axial symptoms such as swallowing and speech...
October 2016: Parkinsonism & related Disorders
Marina Picillo, Andres M Lozano, Nancy Kou, Renato Puppi Munhoz, Alfonso Fasano
BACKGROUND: Deep brain stimulation (DBS) is an established and effective treatment for Parkinson's disease (PD). After surgery, a number of extensive programming sessions are performed to define the most optimal stimulation parameters. Programming sessions mainly rely only on neurologist's experience. As a result, patients often undergo inconsistent and inefficient stimulation changes, as well as unnecessary visits. OBJECTIVE/HYPOTHESIS: We reviewed the literature on initial and follow-up DBS programming procedures and integrated our current practice at Toronto Western Hospital (TWH) to develop standardized DBS programming protocols...
May 2016: Brain Stimulation
Jianyu Li, Yuqing Zhang, Yongjie Li
BACKGROUND AND PURPOSE: The long-term benefits of deep bilateral brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD) are less well described, especially in Chinese cohorts. Here, we present a large group of Chinese PD patients treated with bilateral STN DBS. METHODS: Between 2003 and 2010, 195 consecutive PD patients received implants at the Xuanwu Hospital affiliated to the Capital Medical University in Beijing (China) for bilateral STN DBS...
June 2015: British Journal of Neurosurgery
Emi Isaki, Cynthia Fangman Farrell
This exploratory study evaluated the effectiveness of Apple (Cupertino, CA) iPad(®) (second generation) to deliver telepractice speech and/or language services. Five children and their parents/guardians, as well as four adult participants, received services for communication disorders in a university clinic setting over two academic semesters. The children met some of their speech goals and all of their language goals. All adult clients met some of their communication goals. Personal opinions about telepractice did not change statistically before and after therapy...
July 2015: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Olha Nahorna, Frédéric Berthommier, Jean-Luc Schwartz
While audiovisual interactions in speech perception have long been considered as automatic, recent data suggest that this is not the case. In a previous study, Nahorna et al. [(2012). J. Acoust. Soc. Am. 132, 1061-1077] showed that the McGurk effect is reduced by a previous incoherent audiovisual context. This was interpreted as showing the existence of an audiovisual binding stage controlling the fusion process. Incoherence would produce unbinding and decrease the weight of the visual input in fusion. The present paper explores the audiovisual binding system to characterize its dynamics...
January 2015: Journal of the Acoustical Society of America
Serge Pinto, Murielle Ferraye, Robert Espesser, Valérie Fraix, Audrey Maillet, Jennifer Guirchoum, Deborah Layani-Zemour, Alain Ghio, Stéphan Chabardès, Pierre Pollak, Bettina Debû
Improvement of gait disorders following pedunculopontine nucleus area stimulation in patients with Parkinson's disease has previously been reported and led us to propose this surgical treatment to patients who progressively developed severe gait disorders and freezing despite optimal dopaminergic drug treatment and subthalamic nucleus stimulation. The outcome of our prospective study on the first six patients was somewhat mitigated, as freezing of gait and falls related to freezing were improved by low frequency electrical stimulation of the pedunculopontine nucleus area in some, but not all, patients...
October 2014: Brain: a Journal of Neurology
Ylva Hivand Hiorth, Jan Petter Larsen, Kirsten Lode, Kenn Freddy Pedersen
BACKGROUND: Prospective long-term studies of falls in Parkinson's disease (PD) are scarce. OBJECTIVE: To examine the development of falls over 8 years in a population-based cohort of ambulatory patients with PD, and to investigate predictors of future falls in non-fallers at baseline. METHODS: All patients were examined at baseline and after 4 and 8 years, including the UPDRS, MMSE, Montgomery and Aaberg Depression Rating Scale, Functional Comorbidity Index, and a clinical dementia interview...
October 2014: Parkinsonism & related Disorders
S Vercruysse, M Gilat, J M Shine, E Heremans, S Lewis, A Nieuwboer
Besides the continuous motor impairments that characterize Parkinson's disease (PD), patients are frequently troubled by sudden paroxysmal arrests or brief episodes of movement breakdown, referred to as 'freezing'. Freezing of gait (FOG) is common in advanced PD and typically occurs in walking conditions that challenge dynamic motor-cognitive control. Mounting evidence suggests that episodic motor phenomena during repetitive upper limb (e.g. writing), lower limb (e.g. foot tapping) and speech sequences resemble FOG and may share some underlying neural mechanisms...
June 2014: Neuroscience and Biobehavioral Reviews
R Erro, M R Tedeschi, C Vitale, S Buonocore, G Orefice
BACKGROUND: Freezing of speech (FoS) and other repetitive speech behaviours can frequently occur in parkinsonian syndromes, worsening the efficacy of language functioning, hampering social interactions, and thus reducing quality of life. Pharmacological treatment are ineffective and other interventions have not specifically developed so far. AIM: The aim of this paper was to test the efficacy on a pilot rehabilitation program for freezing of speech based on cueing...
October 2014: European Journal of Physical and Rehabilitation Medicine
Hee Kyung Park, Jong Yoon Yoo, Miseon Kwon, Jae-Hong Lee, Sook Joung Lee, Sung Reul Kim, Mi Jung Kim, Myoung C Lee, Sang Min Lee, Sun Ju Chung
Gait freezing and speech disturbance are disabling axial features of Parkinson's disease (PD). However, the pathogenesis of these features remains unclear. We investigated the relation between changes in gait freezing and speech disturbance using visual and auditory cues in PD. 18 PD patients, comprising of 9 patients with freezing (PDGF) and 9 without gait freezing were studied. Patients performed a 7-m back-and-forth walk in a baseline state and with visual and auditory cues. Gait velocity, stride length and cadence were evaluated using a three-dimensional gait analysis system...
March 2014: Neurological Sciences
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