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https://www.readbyqxmd.com/read/27883239/individually-dosed-omalizumab-an-effective-treatment-for-severe-peanut-allergy
#1
J Brandström, M Vetander, G Lilja, S G O Johansson, A-C Sundqvist, F Kalm, C Nilsson, A Nopp
BACKGROUND: Treatment with omalizumab has shown a positive effect on food allergies, but no dosages are established. Basophil allergen threshold sensitivity (CD-sens) can be used to objectively measure omalizumab treatment efficacy and correlates with the outcome of Double Blind Placebo Controlled Food Challenge to peanut. OBJECTIVE: To evaluate if individualized omalizumab treatment monitored by CD-sens could be an effective intervention for suppression of allergic reactions to peanut...
November 24, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27605701/contact-inhibition-of-locomotion-and-mechanical-cross-talk-between-cell-cell-and-cell-substrate-adhesion-determines-the-pattern-of-junctional-tension-in-epithelial-cell-aggregates
#2
Luke Coburn, Hender Lopez, Benjamin J Caldwell, Elliott Moussa, Chloe Yap, Rashmi Priya, Adrian Noppe, Anthony P Roberts, Vladimir Lobaskin, Alpha S Yap, Zoltan Neufeld, Guillermo A Gomez
We generated a computational approach to analyze the biomechanics of epithelial cell aggregates, either island or stripes or entire monolayers, that combines both vertex and contact-inhibition-of-locomotion models to include both cell-cell and cell-substrate adhesion. Examination of the distribution of cell protrusions (adhesion to the substrate) in the model predicted high order profiles of cell organization that agree with those previously seen experimentally. Cells acquired an asymmetric distribution of basal protrusions, traction forces and apical aspect ratios that decreased when moving from the edge to the island center...
September 7, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27598456/no-association-between-hair-cortisol-or-cortisone-and-brain-morphology-in-children
#3
Ruoqing Chen, Ryan L Muetzel, Hanan El Marroun, Gerard Noppe, Elisabeth F C van Rossum, Vincent W Jaddoe, Frank C Verhulst, Tonya White, Fang Fang, Henning Tiemeier
Little is known about the relationship between the long-term hypothalamic-pituitary-adrenal (HPA) axis functioning and brain structure in children. Glucocorticoid in hair has emerged as an important biomarker of HPA activity. In this study, we investigated the associations of hair cortisol and cortisone concentrations with brain morphology in young children. We included 219 children aged 6-10 years from the Generation R Study in Rotterdam, the Netherlands. We examined cortisol and cortisone concentrations by hair analysis using liquid chromatography-tandem mass spectrometry, and assessed brain morphometric measures with structural magnetic resonance imaging...
August 24, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27411319/pros-and-cons-of-clinical-basophil-testing-bat
#4
REVIEW
Hans Jürgen Hoffmann, Edward F Knol, Martha Ferrer, Lina Mayorga, Vito Sabato, Alexandra F Santos, Bernadette Eberlein, Anna Nopp, Donald MacGlashan
PURPOSE OF REVIEW: We review basophil testing by flow cytometry with an emphasis on advantages and disadvantages. RECENT FINDINGS: There are many tools available to assess the presence and severity of allergic diseases in patients. For 50 years, peripheral blood basophils have been used as tools to study these diseases. It is a very accessible cell that binds IgE antibody and secretes the classical mediators responsible for the symptoms of allergic reactions. In the last decade, an even more accessible methodology, using flow cytometry, has been developed to enhance the ability to use basophils for both mechanistic and clinical diagnostics...
July 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27351351/is-poor-neonatal-adaptation-after-exposure-to-antidepressant-medication-related-to-fetal-cortisol-levels-an-explorative-study
#5
Noera Kieviet, Silke de Groot, Gerard Noppe, Yolanda B de Rijke, Elisabeth F C van Rossum, Erica L T van den Akker, Koert M Dolman, Adriaan Honig
BACKGROUND: As a marker for poor neonatal adaptation (PNA) is lacking, the diagnostic process is difficult and includes invasive additional testing. AIMS: In order to develop a marker, it is essential to gain insight into the etiology of PNA. We hypothesized that the fetal cortisol level may play a role in this etiology. STUDY DESIGN: Non-randomized, prospective controlled study. OUTCOME MEASURES: We examined hair cortisol levels of infants exposed and not exposed to selective antidepressants (SADs) during pregnancy...
July 2016: Early Human Development
https://www.readbyqxmd.com/read/27339603/long-term-glucocorticoid-concentrations-as-a-risk-factor-for-childhood-obesity-and-adverse-body-fat-distribution
#6
G Noppe, E L T van den Akker, Y B de Rijke, J W Koper, V W Jaddoe, E F C van Rossum
BACKGROUND: Childhood obesity is an important risk factor for premature development of the metabolic syndrome (MetS) at adulthood. There is need for understanding of the mechanisms underlying the MetS and obesity. Patients with Cushing's disease suffer from similar metabolic complications, leading to the hypothesis that inter-individual cortisol variation may contribute to the onset of obesity. In addition, glucocorticoid receptor (GR)-gene polymorphisms resulting in differential glucocorticoid (GC) sensitivity, have been associated with an adverse metabolic profile...
July 26, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27192166/college-and-the-grieving-student-a-mixed-methods-analysis
#7
Illene Noppe Cupit, Heather L Servaty-Seib, Sara Tedrick Parikh, Andrea C Walker, Ryan Martin
The current mixed-methods study examines how college students negotiate the grief process with the competing demands of college. Data were collected from 950 students at a regional comprehensive university and a research intensive institution. Quantitative findings revealed closeness to the deceased as a key positive predictor of mental health and academic difficulties and positive associations between changes in peer relationships and mental health difficulties. Qualitative findings showed that closeness to the deceased was associated with a greater sense of purpose in the college experience and findings suggested that institutions and their faculty encourage and exhibit more sensitivity about grief issues...
May 18, 2016: Death Studies
https://www.readbyqxmd.com/read/27061431/scalp-hair-17-hydroxyprogesterone-and-androstenedione-as-a-long-term-therapy-monitoring-tool-in-congenital-adrenal-hyperplasia
#8
Gerard Noppe, Yolanda B de Rijke, Jan W Koper, Elisabeth F C van Rossum, Erica L T van den Akker
BACKGROUND: Glucocorticoid replacement therapy in congenital adrenal hyperplasia (CAH) is challenging, especially in children, because both over- and under-dosing may have profound and long-lasting adverse effects. Clinical follow-up parameters are largely nonspecific and slow to develop. Steroid concentrations in scalp hair may be a useful monitoring tool, as it provides information on both long-term steroid precursor and glucocorticoid exposure. AIM: We aimed to evaluate scalp hair steroid precursor concentrations as a monitoring tool for treatment follow-up in children with CAH...
October 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/26773401/splitting-hair-for-cortisol-associations-of-socio-economic-status-ethnicity-hair-color-gender-and-other-child-characteristics-with-hair-cortisol-and-cortisone
#9
Ralph C A Rippe, Gerard Noppe, Dafna A Windhorst, Henning Tiemeier, Elisabeth F C van Rossum, Vincent W V Jaddoe, Frank C Verhulst, Marian J Bakermans-Kranenburg, Marinus H van IJzendoorn, Erica L T van den Akker
The aim of this study was to examine associations of SES and ethnicity with hair cortisol and cortisone and to identify potential child and family characteristics that can assist in choosing covariates and potential confounders for analyses involving hair cortisol and cortisone concentrations. Hair samples were collected in 2484 6-year-old children from the Generation R Study, a prospective cohort in Rotterdam, the Netherlands. Measurements for cortisol and cortisone were used as the outcome in regression analyses...
April 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/26708067/socioeconomic-status-in-children-is-associated-with-hair-cortisol-levels-as-a-biological-measure-of-chronic-stress
#10
J Vliegenthart, G Noppe, E F C van Rossum, J W Koper, H Raat, E L T van den Akker
INTRODUCTION: Low socioeconomic status (SES) may be associated with a high risk of lifestyle-related diseases such as cardiovascular diseases. There is a strong association between parental SES, stress and indicators of child health and adult health outcome. The exact mechanisms underlying this association have not yet been fully clarified. Low SES may be associated with chronic stress, which may lead to activation of the hypothalamic-pituitary-adrenal (HPA)-axis, resulting in a higher circulating level of the stress hormone cortisol...
March 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/26580089/are-classical-tests-of-repeated-sprint-ability-in-football-externally-valid-a-new-approach-to-determine-in-game-sprinting-behaviour-in-elite-football-players
#11
Jan Schimpchen, Sabrina Skorski, Stephan Nopp, Tim Meyer
The aim of this study was to investigate the occurrence of repeated sprinting bouts in elite football. Furthermore, the construct validity of current tests assessing repeated-sprint ability (RSA) was analysed using information of sprinting sequences as they actually occurred during match-play. Sprinting behaviour in official competition was analysed for 19 games of the German national team between August 2012 and June 2014. A sprinting threshold was individually calculated based on the peak velocity reached during in-game sprinting...
2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/26512808/inhibition-of-alkaline-flocculation-by-algal-organic-matter-for-chlorella-vulgaris
#12
Dries Vandamme, Annelies Beuckels, Eric Vadelius, Orily Depraetere, Wim Noppe, Abhishek Dutta, Imogen Foubert, Lieve Laurens, Koenraad Muylaert
Alkaline flocculation is a promising strategy for the concentration of microalgae for bulk biomass production. However, previous studies have shown that biological changes during the cultivation negatively affect flocculation efficiency. The influence of changes in cell properties and in the quality and composition of algal organic matter (AOM) were studied using Chlorella vulgaris as a model species. In batch cultivation, flocculation was increasingly inhibited over time and mainly influenced by changes in medium composition, rather than biological changes at the cell surface...
January 1, 2016: Water Research
https://www.readbyqxmd.com/read/26452580/top-10-research-questions-related-to-teaching-games-for-understanding
#13
Daniel Memmert, Len Almond, David Bunker, Joy Butler, Frowin Fasold, Linda Griffin, Wolfgang Hillmann, Stefanie Hüttermann, Timo Klein-Soetebier, Stefan König, Stephan Nopp, Marco Rathschlag, Karsten Schul, Sebastian Schwab, Rod Thorpe, Philip Furley
In this article, we elaborate on 10 current research questions related to the "teaching games for understanding" (TGfU) approach with the objective of both developing the model itself and fostering game understanding, tactical decision making, and game-playing ability in invasion and net/wall games: (1) How can existing scientific approaches from different disciplines be used to enhance game play for beginners and proficient players? (2) How can state-of-the-art technology be integrated to game-play evaluations of beginners and proficient players by employing corresponding assessments? (4) How can complexity thinking be utilized to shape day-to-day physical education (PE) and coaching practices? (5) How can game making/designing be helpfully utilized for emergent learning? (6) How could purposeful game design create constraints that enable tactical understanding and skill development through adaptive learning and distributed cognition? (7) How can teacher/coach development programs benefit from game-centered approaches? (8) How can TGfU-related approaches be implemented in teacher or coach education with the goal of facilitating preservice and in-service teachers/coaches' learning to teach and thereby foster their professional development from novices to experienced practitioners? (9) Can the TGfU approach be considered a helpful model across different cultures? (10) Can physical/psychomotor, cognitive, affective/social, and cultural development be fostered via TGfU approaches? The answers to these questions are critical not only for the advancement of teaching and coaching in PE and sport-based clubs, but also for an in-depth discussion on new scientific avenues and technological tools...
2015: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/26276341/observation-of-the-early-structural-changes-leading-to-the-formation-of-protein-superstructures
#14
Vito Foderà, Valeria Vetri, Thea S Wind, Wim Noppe, Claus Cornett, Athene M Donald, Ludmilla A Morozova-Roche, Bente Vestergaard
Formation of superstructures in protein aggregation processes has been indicated as a general pathway for several proteins, possibly playing a role in human pathologies. There is a severe lack of knowledge on the origin of such species in terms of both mechanisms of formation and structural features. We use equine lysozyme as a model protein, and by combining spectroscopic techniques and microscopy with X-ray fiber diffraction and ab initio modeling of Small Angle X-ray Scattering data, we isolate the partially unfolded state from which one of these superstructures (i...
September 18, 2014: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/26198455/the-clinical-utility-of-basophil-activation-testing-in-diagnosis-and-monitoring-of-allergic-disease
#15
REVIEW
H J Hoffmann, A F Santos, C Mayorga, A Nopp, B Eberlein, M Ferrer, P Rouzaire, D G Ebo, V Sabato, M L Sanz, T Pecaric-Petkovic, S U Patil, O V Hausmann, W G Shreffler, P Korosec, E F Knol
The basophil activation test (BAT) has become a pervasive test for allergic response through the development of flow cytometry, discovery of activation markers such as CD63 and unique markers identifying basophil granulocytes. Basophil activation test measures basophil response to allergen cross-linking IgE on between 150 and 2000 basophil granulocytes in <0.1 ml fresh blood. Dichotomous activation is assessed as the fraction of reacting basophils. In addition to clinical history, skin prick test, and specific IgE determination, BAT can be a part of the diagnostic evaluation of patients with food-, insect venom-, and drug allergy and chronic urticaria...
November 2015: Allergy
https://www.readbyqxmd.com/read/26119963/modelling-wound-closure-in-an-epithelial-cell-sheet-using-the-cellular-potts-model
#16
Adrian R Noppe, Anthony P Roberts, Alpha S Yap, Guillermo A Gomez, Zoltan Neufeld
We use a two-dimensional cellular Potts model to represent the behavior of an epithelial cell layer and describe its dynamics in response to a microscopic wound. Using an energy function to describe properties of the cells, we found that the interaction between contractile tension along cell-cell junctions and cell-cell adhesion plays an important role not only in determining the dynamics and morphology of cells in the monolayer, but also in influencing whether or not a wound in the monolayer will close. Our results suggest that, depending on the balance between cell-cell adhesion and junctional tension, mechanics of the monolayer can either correspond to a hard or a soft regime that determines cell morphology and polygonal organization in the monolayer...
October 2015: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/25878561/evaluation-of-basophil-allergen-threshold-sensitivity-cd-sens-to-peanut-and-ara-h-8-in-children-ige-sensitized-to-ara-h-8
#17
Susanne Glaumann, Caroline Nilsson, S G O Johansson, Anna Asarnoj, Magnus Wickman, Magnus P Borres, Anna Nopp
BACKGROUND: Diagnosing peanut allergy properly is important and can be achieved by combining clinical history with various diagnostic methods such as IgE-antibody (IgE-ab) measurements, skin-prick test, basophil allergen threshold sensitivity (CD-sens) and food challenge. We aimed to evaluate CD-sens to peanut, Ara h 8 and Gly m 4 in relation to an oral peanut challenge in children IgE-sensitized to birch, peanut and Ara h 8 avoiding peanuts. METHODS: Twenty children IgE-sensitized to birch pollen and Ara h 8, but not to Ara h 1, Ara h 2 or Ara h 3 were challenged orally with roasted peanuts...
2015: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/25823708/lc-ms-ms-based-method-for-long-term-steroid-profiling-in-human-scalp-hair
#18
Gerard Noppe, Yolanda B de Rijke, Kristien Dorst, Erica L T van den Akker, Elisabeth F C van Rossum
BACKGROUND: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the method of choice for quantification of steroids. Human scalp hair provides the possibility to measure long-term retrospective steroid concentrations, which is especially useful for steroids with large time-dependent fluctuations in concentration, such as the glucocorticoid cortisol. AIM: We set up and validated a LC-MS/MS-based method for long-term steroid profiling, quantifying cortisol, cortisone, testosterone, androstenedione, dehydroepiandrosterone sulphate (DHEAS) and 17-α-hydroxyprogesterone (17OHP)...
August 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25707509/basophil-allergen-threshold-sensitivity-and-component-resolved-diagnostics-improve-hazelnut-allergy-diagnosis
#19
RANDOMIZED CONTROLLED TRIAL
J Brandström, A Nopp, S G O Johansson, G Lilja, A-C Sundqvist, M P Borres, C Nilsson
BACKGROUND: IgE sensitization to hazelnut is common, especially in birch endemic areas. However, its clinical significance often needs to be confirmed by a food challenge. OBJECTIVE: To evaluate the clinical significance of IgE antibodies to hazelnut components and basophil allergen threshold sensitivity (CD-sens) to hazelnut, in relation to double-blind placebo-controlled food challenge (DBPCFC) in children with a suspected hazelnut allergy. METHODS: Forty children underwent a DBPCFC...
September 2015: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25456089/deep-electrode-insertion-and-sound-coding-in-cochlear-implants
#20
REVIEW
Ingeborg Hochmair, Erwin Hochmair, Peter Nopp, Melissa Waller, Claude Jolly
Present-day cochlear implants demonstrate remarkable speech understanding performance despite the use of non-optimized coding strategies concerning the transmission of tonal information. Most systems rely on place pitch information despite possibly large deviations from correct tonotopic placement of stimulation sites. Low frequency information is limited as well because of the constant pulse rate stimulation generally used and, being even more restrictive, of the limited insertion depth of the electrodes. This results in a compromised perception of music and tonal languages...
April 2015: Hearing Research
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