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JOURNAL ARTICLE
Z R Shapiro, J A Kable, T M Grant, S A Stoner, C D Coles
BACKGROUND: Prenatal alcohol exposure (PAE) impacts cognition in childhood and early adulthood. Here we evaluate the cognitive abilities of middle-aged adults with and without a history of PAE. METHODS: Participants (N = 200) were recruited from longitudinal cohorts in the Atlanta and Seattle metropolitan areas and completed measures comprising the National Institutes of Health Toolbox's Fluid Cognition Composite. RESULTS: We found that individuals with PAE had lower Fluid Cognition Summary scores and lower Dimensional Change Card Sort and Flanker task subtest scores than non-PAE controls, after accounting for both potentially confounding demographic variables using propensity scores and the effects of study site...
October 2023: Alcohol Clin Exp Res (Hoboken)
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JOURNAL ARTICLE
Gayathri Nagaraj, Shaveta Vinayak, Ali Raza Khaki, Tianyi Sun, Nicole M Kuderer, David M Aboulafia, Jared D Acoba, Joy Awosika, Ziad Bakouny, Nicole B Balmaceda, Ting Bao, Babar Bashir, Stephanie Berg, Mehmet A Bilen, Poorva Bindal, Sibel Blau, Brianne E Bodin, Hala T Borno, Cecilia Castellano, Horyun Choi, John Deeken, Aakash Desai, Natasha Edwin, Lawrence E Feldman, Daniel B Flora, Christopher R Friese, Matthew D Galsky, Cyndi J Gonzalez, Petros Grivas, Shilpa Gupta, Marcy Haynam, Hannah Heilman, Dawn L Hershman, Clara Hwang, Chinmay Jani, Sachin R Jhawar, Monika Joshi, Virginia Kaklamani, Elizabeth J Klein, Natalie Knox, Vadim S Koshkin, Amit A Kulkarni, Daniel H Kwon, Chris Labaki, Philip E Lammers, Kate I Lathrop, Mark A Lewis, Xuanyi Li, Gilbert de Lima Lopes, Gary H Lyman, Della F Makower, Abdul-Hai Mansoor, Merry-Jennifer Markham, Sandeep H Mashru, Rana R McKay, Ian Messing, Vasil Mico, Rajani Nadkarni, Swathi Namburi, Ryan H Nguyen, Taylor Kristian Nonato, Tracey Lynn O'Connor, Orestis A Panagiotou, Kyu Park, Jaymin M Patel, Kanishka GopikaBimal Patel, Jeffrey Peppercorn, Hyma Polimera, Matthew Puc, Yuan James Rao, Pedram Razavi, Sonya A Reid, Jonathan W Riess, Donna R Rivera, Mark Robson, Suzanne J Rose, Atlantis D Russ, Lidia Schapira, Pankil K Shah, M Kelly Shanahan, Lauren C Shapiro, Melissa Smits, Daniel G Stover, Mitrianna Streckfuss, Lisa Tachiki, Michael A Thompson, Sara M Tolaney, Lisa B Weissmann, Grace Wilson, Michael T Wotman, Elizabeth M Wulff-Burchfield, Sanjay Mishra, Benjamin French, Jeremy L Warner, Maryam B Lustberg, Melissa K Accordino, Dimpy P Shah
Background: Limited information is available for patients with breast cancer (BC) and coronavirus disease 2019 (COVID-19), especially among underrepresented racial/ethnic populations. Methods: This is a COVID-19 and Cancer Consortium (CCC19) registry-based retrospective cohort study of females with active or history of BC and laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection diagnosed between March 2020 and June 2021 in the US. Primary outcome was COVID-19 severity measured on a five-level ordinal scale, including none of the following complications, hospitalization, intensive care unit admission, mechanical ventilation, and all-cause mortality...
October 17, 2023: ELife
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JOURNAL ARTICLE
Mark J Panaggio, Mike Fang, Hyunseung Bang, Paige A Armstrong, Alison M Binder, Julian E Grass, Jake Magid, Marc Papazian, Carrie K Shapiro-Mendoza, Sharyn E Parks
During the COVID-19 pandemic, many public schools across the United States shifted from fully in-person learning to alternative learning modalities such as hybrid and fully remote learning. In this study, data from 14,688 unique school districts from August 2020 to June 2021 were collected to track changes in the proportion of schools offering fully in-person, hybrid and fully remote learning over time. These data were provided by Burbio, MCH Strategic Data, the American Enterprise Institute's Return to Learn Tracker and individual state dashboards...
2023: PloS One
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JOURNAL ARTICLE
Customised enriched coconut oil as panacea for oral biofilm mediated diseases - A prospective study.
Shamini Sai, Raga T Nivedha, Srinivasan Narasimhan, Aruna K Veronica, Jayaraman Selvakumar, Anand V Susila
AIMS: To evaluate a customised enriched formulation of coconut (CEC) oil with Arimedadi Tailam (AT) and 0.2% chlorhexidine mouth rinse (CHX) for their plaque control and potential anticaries effects using the oratest in healthy volunteers. SETTINGS AND DESIGN: Parallel, double-blinded (outcome assessor and statistician), randomised controlled institution-based pilot study. METHODS AND MATERIALS: 60 adults (18-22 years) having DMFT score of 2-11, gingival and plaque index as zero, no history of antibiotics for one month or fluoride application in 2 weeks were randomly divided (computer-generated list) and allocated into 3 groups (A-CHX, B-CEC, C-AT) of 20 subjects each based on the intervention...
2023: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
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JOURNAL ARTICLE
Juan D Saborido-Moral, Matías Fernández-Patón, Natalia Tejedor-Aguilar, Andrei Cristian-Marín, Irene Torres-Espallardo, Juan M Campayo-Esteban, José Pérez-Calatayud, Dimos Baltas, Luis Martí-Bonmatí, Montserrat Carles
PURPOSE: To develop a QA procedure, easy to use, reproducible and based on open-source code, to automatically evaluate the stability of different metrics extracted from CT images: Hounsfield Unit (HU) calibration, edge characterization metrics (contrast and drop range) and radiomic features. METHODS: The QA protocol was based on electron density phantom imaging. Home-made open-source Python code was developed for the automatic computation of the metrics and their reproducibility analysis...
September 29, 2023: Physica Medica: PM
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JOURNAL ARTICLE
Joel Martínez-Salazar, Filiberto Toledano-Toledano
Predictive models play a crucial role in RBMs to analyze performance indicator results to manage unexpected events and make timely decisions to resolve them. Their use in Mexico is deficient, and monitoring and evaluation are among the weakest pillars of the model. In response to these needs, the aim of this study was to perform a comparative analysis of three predictive models to analyze 10 medical performance indicators and cancer data related to children with cancer. To accomplish these purposes, a comparative and retrospective study with nonprobabilistic convenience sampling was conducted...
September 20, 2023: Cancers
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JOURNAL ARTICLE
David B Kurland, Matin Lendhey, Nader Delavari, Jalen Winfield, Jonathan M Mahoney, Tibor Becske, Maksim Shapiro, Eytan Raz, Donato Pacione, Brandon S Bucklen, Anthony K Frempong-Boadu
BACKGROUND AND OBJECTIVES: Instrumented spinal fusion constructs sometimes fail because of fatigue loading, frequently necessitating open revision surgery. Favorable outcomes after percutaneous juxtapedicular cement salvage (perc-cement salvage) of failing instrumentation have been described; however, this approach is not widely known among spine surgeons, and its biomechanical properties have not been evaluated. We report our institutional experience with perc-cement salvage and investigate the relative biomechanical strength of this technique as compared with 3 other common open revision techniques...
September 25, 2023: Operative Neurosurgery (Hagerstown, Md.)
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JOURNAL ARTICLE
A González, W Gutiérrez, T Fuenzalida, F Lizana, M Gutiérrez, N Severino
OBJECTIVES: The Pharmacotherapeutic follow-up program (PFU) carried out by the clinical pharmacist can be categorized within 3 fundamental activities; identification, resolution and prevention of adverse drug events. These must be adjusted to the requirements and resources of each institution, developing procedures to increase PFU efficiency and to guarantee patient safety. The clinical pharmacists of UC-CHRISTUS Healthcare Network developed a Standardized Pharmacotherapeutic Evaluation Process (SPEP)...
September 19, 2023: Farmacia Hospitalaria
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MULTICENTER STUDY
Ashanda R Esdaille, Jose A Karam, Viraj A Master, Philippe E Spiess, Jay D Raman, Pranav Sharma, Daniel D Shapiro, Arighno Das, Wade J Sexton, Logan Zemp, Dattatraya Patil, Glenn O Allen, Surena F Matin, Christopher G Wood, Jason E Abel
OBJECTIVE: To evaluate factors associated with perioperative outcomes in a multi-institutional cohort of patients treated with cytoreductive nephrectomy (CN). METHODS: Data were analyzed for metastatic renal cell carcinoma patients treated with CN at 6 tertiary academic centers from 2005 to 2019. Outcomes included: Clavien-Dindo complications, mortality, length of hospitalization, 30-day readmission rate, and time to systemic therapy. Univariate and multivariable models evaluated associations between outcomes and prognostic variables including the year of surgery...
December 2023: Urology
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EDITORIAL
Einat Albin, Shikma Bressler, Asya Rolls, Michal Schwartz, Ehud Shapiro
Over the past 30 weeks, Israel has been undergoing an upheaval marked by unprecedented attacks by the government on the independence of its judiciary, attorney general, government legal advisers, police, military, public broadcasting, and religious freedom. This assault on democratic institutions and principles is an imminent threat to Israeli academia, which relies on a solid democratic foundation. In response, universities, academics, and students have emerged as key proponents of ongoing protests under the banner, "No democracy, no academia...
August 18, 2023: Science
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JOURNAL ARTICLE
Pabel A Miah, Nakisa Pourkey, Alyssa Marmer, Athanasios Sevdalis, Laura Fiedler, Charles DiMaggio, Linda Pak, Richard Shapiro, Karen Hiotis, Deborah Axelrod, Amber Guth, Freya Schnabel
BACKGROUND: Screening MRI as an adjunct to mammography is recommended by the ACS for patients with a lifetime risk for breast cancer > 20%. While the benefits are clear, MRI screening is associated with an increase in false-positive results. The purpose of this study was to analyze our institutional database of high-risk patients and assess the uptake of screening MRI examinations and the results of those screenings. METHODS: Our institutional review board-approved High-Risk Breast Cancer Database was queried for patients enrolled from January 2017 to January 2023 who were at high risk for breast cancer in a comparative analysis between those who were screened versus not screened with MRIs...
August 10, 2023: Annals of Surgical Oncology
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JOURNAL ARTICLE
Tarik Wasfie, Matthew Sowa, Hutton White, Sara N Nesheiwat Oms-Iv, Jennifer Hille, Jennifer Hella, Kimberly Barber, Brian Shapiro
Rib fractures in the elderly are one of the most common injuries in trauma patients admitted to the hospital, accounting for over 350,000 patients annually in the United States. Rib plating has been shown to be most beneficial among certain populations. Early surgical intervention is important to utilize approaches that limit the use of pain medications. This is a retrospective data analysis to determine the efficacy of rib plating in elderly trauma patients with rib fractures. A total of 253 patients were seen with rib fractures, 63% were male and 37% were female...
July 2023: American Surgeon
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JOURNAL ARTICLE
Harshabad Singh, Rachel B Keller, Kevin S Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Elizabeth F Cohen, Michael Tolstorukov, Elizabeth Andrews, Lauren K Brais, Annacarolina da Silva, Kimberly Perez, Douglas A Rubinson, Rishi Surana, Marios Giannakis, Kimmie Ng, Thomas E Clancy, Matthew B Yurgelun, Benjamin L Schlechter, Jeffrey W Clark, Geoffrey I Shapiro, Michael H Rosenthal, Jason L Hornick, Valentina Nardi, Yvonne Y Li, Hersh Gupta, Andrew D Cherniack, Matthew Meyerson, James M Cleary, Jonathan A Nowak, Brian M Wolpin, Andrew J Aguirre
PURPOSE: Approximately 8-10% of pancreatic ductal adenocarcinomas (PDAC) do not harbor mutations in KRAS. Understanding the unique molecular and clinical features of this subset of pancreatic cancer is important to guide patient stratification for clinical trials of molecularly targeted agents. EXPERIMENTAL DESIGN: We analyzed a single-institution cohort of 795 exocrine pancreatic cancer cases (including 785 PDAC cases) with a targeted multi-gene sequencing panel and identified 73 patients (9...
July 18, 2023: Clinical Cancer Research
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JOURNAL ARTICLE
Rahul Silori, Manish Kumar, Durga Madhab Mahapatra, Pinakshi Biswas, Bhanu Prakash Vellanki, Jürgen Mahlknecht, Syed Mohammad Tauseef, Damia Barcelo
We quantified the occurrences and seasonal variations of the target Endocrine disrupting chemicals (EDCs) at four (two major municipals, and two academic institutions) WWTPs in Dehradun city, Uttarakhand, India. The results showed estrone in higher concentrations at μgL-1 levels in influent among the WWTPs, compared to triclosan (TCS) at ngL-1 levels. An astounding concentration of 123.95 μgL-1 was recorded for the estrone in the influent, which is to date the highest ever recorded, globally...
July 14, 2023: Environmental Research
#35
JOURNAL ARTICLE
E Jason Abel, Viraj A Master, Philippe E Spiess, Jay D Raman, Daniel D Shapiro, Wade J Sexton, Logan Zemp, Dattatraya Patil, Kate Lauer, Glenn O Allen, Surena F Matin, Jose A Karam
BACKGROUND: Careful patient selection is critical when considering cytoreductive nephrectomy (CN) for metastatic renal cell carcinoma (mRCC) but few studies have investigated the prognostic value of radiologic features that measure tumor burden. OBJECTIVE: To develop a prognostic model to improve CN selection with integration of common radiologic features with known prognostic factors associated with mortality in the first year following surgery. DESIGN, SETTINGS, AND PARTICIPANTS: Data were analyzed for consecutive patients with mRCC treated with upfront CN at five institutions from 2006 to 2017...
July 11, 2023: European Urology Oncology
#36
JOURNAL ARTICLE
Charlotte Heleniak, Bonnie Goff, Laurel J Gabard-Durnam, Eva H Telzer, Kathryn L Humphreys, Daniel S Lumian, Jessica E Flannery, Christina Caldera, Mor Shapiro, Jennifer Y Louie, Fan Shen, Anna Vannucci, Maitri Jain, Charles E Glatt, Nim Tottenham
OBJECTIVE: A large literature has identified exposure to early caregiving adversities as a potent risk for developing affective psychopathology, with depression, in particular, increasing across childhood into adolescence. Evidence suggests telomere erosion, a marker of biological aging, may underlie associations between adverse early-life experiences and later depressive behavior; yet, little is understood about this association during development. METHOD: The current accelerated longitudinal study examined concurrent telomere length and depressive symptoms concurrently, 2 and 4 years later, from the preschool period through adolescence among children exposed (n =116) and not exposed (n = 242) to early previous institutional (PI) care...
June 23, 2023: Journal of the American Academy of Child and Adolescent Psychiatry
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JOURNAL ARTICLE
Grégoire B Morand, Antoine Eskander, Rui Fu, John de Almeida, David Goldstein, Hesameddin Noroozi, Ali Hosni, Hadi Seikaly, Paul Tabet, Justin M Pyne, T Wayne Matthews, Joseph Dort, Steve Nakoneshny, Apostolos Christopoulos, Houda Bahig, Stephanie Johnson-Obaseki, Nadia Hua, Marc Gaudet, Alborz Jooya, Anthony Nichols, Francisco Laxague, Matthew Cecchini, Jenny Du, Justin Shapiro, Irene Karam, Peter T Dziegielewski, Krishna Hanubal, Boban Erovic, Stefan Grasl, Joel Davies, Eric Monteiro, Maru Gete, Ian Witterick, Nader Sadeghi, Keith Richardson, George Shenouda, Anastasios Maniakas, Vivianne Landry, Michael Gupta, Kelvin Zhou, Alex M Mlynarek, Marc Pusztaszeri, Khalil Sultanem, Michael P Hier
BACKGROUND: The objective of this study was to examine the utility of postoperative radiation for low and intermediate grade cancers of the parotid and submandibular glands. METHODS: The authors conducted a retrospective, Canadian-led, international, multi-institutional analysis of a patient cohort with low or intermediate grade salivary gland cancer of the parotid or submandibular gland who were treated from 2010 until 2020 with or without postoperative radiation therapy...
July 4, 2023: Cancer
#38
JOURNAL ARTICLE
Muhammad Safwan Riaz, Steven F Moss, Jason M Shapiro, Carolina Cerezo, Michael Herzlinger
BACKGROUND: In 2016, ESPGHAN/NASPGHAN issued revised guidelines for the management of Helicobacter pylori (H. pylori) infection in children and adolescents. Recommendations include performing antibiotic susceptibility testing to tailor therapy. The aim of our study was to evaluate the H. pylori treatment landscape in pediatric patients at our institution. METHODS: We performed a retrospective study of patients diagnosed with H. pylori infection at a single academic children's hospital from 2015 to 2021...
July 5, 2023: Rhode Island Medical Journal
#39
JOURNAL ARTICLE
Amandeep Singh, Amitojveer S Josan, Kamlesh Gupta, Sangeeta Pahwa
Background There are very few studies on the association between fetal epicardial fat thickness (EFT) and gestational diabetes mellitus (GDM). Aims To evaluate the role of fetal epicardial fat thickness as a marker and use it in pregnancies to screen for GDM. Settings and Design A cross-sectional analytical study was conducted in the Department of Radiodiagnosis and Imaging at Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, after the due clearance from the institutional research and ethics committee...
July 2023: Indian Journal of Radiology & Imaging
#40
JOURNAL ARTICLE
Carter J Boyd, Jonathan M Bekisz, Sruthi Ramesh, Kshipra Hemal, Amber A Guth, Deborah M Axelrod, Richard L Shapiro, Karen Hiotis, Freya R Schnabel, Mihye Choi, Nolan S Karp
UNLABELLED: Prophylactic nipple-sparing mastectomies (NSM) have become increasingly common, although there is little long-term data on its efficacy in prevention of breast cancer. The objective of this study was to assess the incidence of breast cancer in a cohort of patients undergoing prophylactic NSM with a median follow-up of 10 years. METHODS: Patients receiving prophylactic NSM at a single institution from 2006 to 2019 were included in a retrospective nature...
June 2023: Plastic and Reconstructive Surgery. Global Open
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