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https://www.readbyqxmd.com/read/27882345/institutional-implementation-of-clinical-tumor-profiling-on-an-unselected-cancer-population
#1
Lynette M Sholl, Khanh Do, Priyanka Shivdasani, Ethan Cerami, Adrian M Dubuc, Frank C Kuo, Elizabeth P Garcia, Yonghui Jia, Phani Davineni, Ryan P Abo, Trevor J Pugh, Paul van Hummelen, Aaron R Thorner, Matthew Ducar, Alice H Berger, Mizuki Nishino, Katherine A Janeway, Alanna Church, Marian Harris, Lauren L Ritterhouse, Joshua D Campbell, Vanesa Rojas-Rudilla, Azra H Ligon, Shakti Ramkissoon, James M Cleary, Ursula Matulonis, Geoffrey R Oxnard, Richard Chao, Vanessa Tassell, James Christensen, William C Hahn, Philip W Kantoff, David J Kwiatkowski, Bruce E Johnson, Matthew Meyerson, Levi A Garraway, Geoffrey I Shapiro, Barrett J Rollins, Neal I Lindeman, Laura E MacConaill
BACKGROUND. Comprehensive genomic profiling of a patient's cancer can be used to diagnose, monitor, and recommend treatment. Clinical implementation of tumor profiling in an enterprise-wide, unselected cancer patient population has yet to be reported. METHODS. We deployed a hybrid-capture and massively parallel sequencing assay (OncoPanel) for all adult and pediatric patients at our combined cancer centers. Results were categorized by pathologists based on actionability. We report the results for the first 3,727 patients tested...
November 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27830178/diaphragmatic-hernia-after-living-donor-right-hepatectomy-proposal-for-a-screening-protocol
#2
Scott M Livingstone, Axel Andres, A M James Shapiro, Norman N Kneteman, David L Bigam
BACKGROUND: Living donor hepatectomy (LDH) is increasingly being used to improve access to liver transplantation for those with end-stage liver disease. Although recipient outcomes are equivalent, donor complication rates range from 10% to 41%. A rare, but potentially serious complication is occurrence of a diaphragmatic hernia (DH), of which 9 cases have been reported so far in the literature. The purpose of this work was to review the clinical impact of DH post-LDH, including risk factors (RF) in hope of mitigating impact...
July 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27806243/benefits-and-risks-of-antiretroviral-therapy-for-perinatal-hiv-prevention
#3
Mary G Fowler, Min Qin, Susan A Fiscus, Judith S Currier, Patricia M Flynn, Tsungai Chipato, James McIntyre, Devasena Gnanashanmugam, George K Siberry, Anne S Coletti, Taha E Taha, Karin L Klingman, Francis E Martinson, Maxensia Owor, Avy Violari, Dhayendre Moodley, Gerhard B Theron, Ramesh Bhosale, Raziya Bobat, Benjamin H Chi, Renate Strehlau, Pendo Mlay, Amy J Loftis, Renee Browning, Terence Fenton, Lynette Purdue, Michael Basar, David E Shapiro, Lynne M Mofenson
Background Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevirapine to prevent transmission of the human immunodeficiency virus (HIV) in HIV-infected pregnant women with high CD4 counts are lacking. Methods We randomly assigned HIV-infected women at 14 or more weeks of gestation with CD4 counts of at least 350 cells per cubic millimeter to zidovudine and single-dose nevirapine plus a 1-to-2-week postpartum "tail" of tenofovir and emtricitabine (zidovudine alone); zidovudine, lamivudine, and lopinavir-ritonavir (zidovudine-based ART); or tenofovir, emtricitabine, and lopinavir-ritonavir (tenofovir-based ART)...
November 3, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27798172/update-on-gender-equity-in-immunology-2001-to-2016
#4
Virginia Smith Shapiro, Susan Kovats, Michelle A Parent, Sarah L Gaffen, Catherine C Hedrick, Pooja Jain, Lisa K Denzin, Malini Raghavan, Robin Stephens
In 2001, The American Association of Immunologists Committee on the Status of Women conducted a survey examining the percentage of women faculty members within immunology departments or women in immunology graduate programs across 27 institutions in the United States, comparing it to the percentage of women receiving a Ph.D. Here, we examine the representation of women across these same 27 immunology departments and programs to examine changes in gender equity over the last 15 years.
October 17, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27783257/is-poor-working-memory-a-transdiagnostic-risk-factor-for-psychopathology
#5
Cynthia Huang-Pollock, Zvi Shapiro, Hilary Galloway-Long, Alex Weigard
In contrast to historical conceptualizations that framed psychological disorders as distinct, categorical conditions, it is now widely understood that co- and multi-morbidities between disorders are extensive. As a result, there has been a call to better understand the dimensional liabilities that are common to and influence the development of multiple psychopathologies, as supported and exemplified by the National Institutes of Mental Health (NIMH) Research Domain Criteria (RDoC) framework. We use a latent variable SEM approach to examine the degree to which working memory deficits represent a cognitive liability associated with the development of common and discrete dimensions of psychopathology...
October 25, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27782975/obliterative-versus-reconstructive-prolapse-repair-for-women-older-than-70-is-there-an-optimal-approach
#6
Sybil G Dessie, Alex Shapiro, Miriam J Haviland, Michele R Hacker, Eman A Elkadry
OBJECTIVES: This study aimed to evaluate outcomes among women 70 years and older who underwent obliterative compared with reconstructive procedures for pelvic organ prolapse. METHODS: This was a retrospective cohort study of patients 70 years and older who underwent surgical prolapse repair at our institution from January 2004 through June 2010. Only patients with at least 4 weeks of follow-up were included. Patient characteristics and relevant pre, intra, and postoperative information were abstracted from medical records...
October 25, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27782829/the-effect-of-skin-to-skin-contact-at-birth-early-versus-immediate-on-the-duration-of-exclusive-human-lactancy-in-full-term-newborns-treated-at-the-cl%C3%A3-nica-universidad-de-la-sabana-study-protocol-for-a-randomized-clinical-trial
#7
Sergio Agudelo, Oscar Gamboa, Fabio Rodríguez, Sandra Cala, Nathalie Gualdrón, Evelyn Obando, María Lucía Padrón
BACKGROUND: Human lactancy is a simple and cost-effective strategy that influences infant and maternal mortality rates. Skin-to-skin contact (SSC) is an immediate postpartum period strategy that has proven to benefit the initiation and continuation of human lactation and to decrease hospitalization during the first week of life. This study aims to determine the effect of SSC initiation at birth (immediate versus early) in healthy, full-term newborns treated at the Universidad de La Sabana Clinic on the duration of exclusive human lactation...
October 26, 2016: Trials
https://www.readbyqxmd.com/read/27617057/complete-genome-sequence-of-desulfurivibrio-alkaliphilus-strain-aht2-t-a-haloalkaliphilic-sulfidogen-from-egyptian-hypersaline-alkaline-lakes
#8
Emily Denise Melton, Dimitry Y Sorokin, Lex Overmars, Olga Chertkov, Alicia Clum, Manoj Pillay, Natalia Ivanova, Nicole Shapiro, Nikos C Kyrpides, Tanja Woyke, Alla L Lapidus, Gerard Muyzer
Desulfurivibrio alkaliphilus strain AHT2(T) is a strictly anaerobic sulfidogenic haloalkaliphile isolated from a composite sediment sample of eight hypersaline alkaline lakes in the Wadi al Natrun valley in the Egyptian Libyan Desert. D. alkaliphilus AHT2(T) is Gram-negative and belongs to the family Desulfobulbaceae within the Deltaproteobacteria. Here we report its genome sequence, which contains a 3.10 Mbp chromosome. D. alkaliphilus AHT2(T) is adapted to survive under highly alkaline and moderately saline conditions and therefore, is relevant to the biotechnology industry and life under extreme conditions...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27612917/a-systematic-analysis-of-2-monoisocentric-techniques-for-the-treatment-of-multiple-brain-metastases
#9
Ganesh Narayanasamy, Sotirios Stathakis, Alonso N Gutierrez, Evangelos Pappas, Richard Crownover, John R Floyd, Niko Papanikolaou
BACKGROUND: In this treatment planning study, we compare the plan quality and delivery parameters for the treatment of multiple brain metastases using 2 monoisocentric techniques: the Multiple Metastases Element from Brainlab and the RapidArc volumetric-modulated arc therapy from Varian Medical Systems. METHODS: Eight patients who were treated in our institution for multiple metastases (3-7 lesions) were replanned with Multiple Metastases Element using noncoplanar dynamic conformal arcs...
September 9, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27596130/outcome-of-allogeneic-hematopoietic-stem-cell-transplantation-for-patients-with-chronic-and-advanced-phase-myelofibrosis
#10
Alla Keyzner, Sarah Han, Samantha Shapiro, Erin Moshier, Emily Schorr, Bruce Petersen, Vesna Najfeld, Marina Kremyanskaya, Luis Isola, Ronald Hoffman, John Mascarenhas
Myelofibrosis (MF) is a chronic progressive hematologic malignancy with a median overall survival (OS) of approximately 6 years. Allogeneic hematopoietic stem cell transplantation (HSCT) is the sole treatment approach that offers curative potential. The use of reduced-intensity conditioning regimens has expanded the application of HSCT to patients with MF up to age 70 years. Recent retrospective and prospective reports have suggested worse HSCT outcomes for patients with MF receiving an unrelated donor graft compared with those receiving a related donor graft...
September 3, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27532500/association-between-intensive-care-unit-utilization-during-hospitalization-and-costs-use-of-invasive-procedures-and-mortality
#11
Dong W Chang, Martin F Shapiro
Importance: Maximizing the value of critical care services requires understanding the relationship between intensive care unit (ICU) utilization, clinical outcomes, and costs. Objective: To examine whether hospitals had consistent patterns of ICU utilization across 4 common medical conditions and the association between higher use of the ICU and hospital costs, use of invasive procedures, and mortality. Design, Setting, and Participants: Retrospective cohort study of 156 842 hospitalizations in 94 acute-care nonfederal hospitals for diabetic ketoacidosis (DKA), pulmonary embolism (PE), upper gastrointestinal bleeding (UGIB), and congestive heart failure (CHF) in Washington state and Maryland from 2010 to 2012...
October 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27471578/complete-genome-of-nitrosospira-briensis-c-128-an-ammonia-oxidizing-bacterium-from-agricultural-soil
#12
Marlen C Rice, Jeanette M Norton, Frederica Valois, Annette Bollmann, Peter J Bottomley, Martin G Klotz, Hendrikus J Laanbroek, Yuichi Suwa, Lisa Y Stein, Luis Sayavedra-Soto, Tanja Woyke, Nicole Shapiro, Lynne A Goodwin, Marcel Huntemann, Alicia Clum, Manoj Pillay, Nikos Kyrpides, Neha Varghese, Natalia Mikhailova, Victor Markowitz, Krishna Palaniappan, Natalia Ivanova, Dimitrios Stamatis, T B K Reddy, Chew Yee Ngan, Chris Daum
Nitrosospira briensis C-128 is an ammonia-oxidizing bacterium isolated from an acid agricultural soil. N. briensis C-128 was sequenced with PacBio RS technologies at the DOE-Joint Genome Institute through their Community Science Program (2010). The high-quality finished genome contains one chromosome of 3.21 Mb and no plasmids. We identified 3073 gene models, 3018 of which are protein coding. The two-way average nucleotide identity between the chromosomes of Nitrosospira multiformis ATCC 25196 and Nitrosospira briensis C-128 was found to be 77...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27443431/hybrid-coronary-revascularization-for%C3%A2-the%C3%A2-treatment-of-multivessel-coronary%C3%A2-artery-disease-a-multicenter-observational-study
#13
John D Puskas, Michael E Halkos, Joseph J DeRose, Emilia Bagiella, Marissa A Miller, Jessica Overbey, Johannes Bonatti, V S Srinivas, Mark Vesely, Francis Sutter, Janine Lynch, Katherine Kirkwood, Timothy A Shapiro, Konstantinos D Boudoulas, Juan Crestanello, Thomas Gehrig, Peter Smith, Michael Ragosta, Steven J Hoff, David Zhao, Annetine C Gelijns, Wilson Y Szeto, Giora Weisz, Michael Argenziano, Thomas Vassiliades, Henry Liberman, William Matthai, Deborah D Ascheim
BACKGROUND: Hybrid coronary revascularization (HCR) combines minimally invasive surgical coronary artery bypass grafting of the left anterior descending artery with percutaneous coronary intervention (PCI) of non-left anterior descending vessels. HCR is increasingly used to treat multivessel coronary artery disease that includes stenoses in the proximal left anterior descending artery and at least 1 other vessel, but its effectiveness has not been rigorously evaluated. OBJECTIVES: This National Institutes of Health-funded, multicenter, observational study was conducted to explore the characteristics and outcomes of patients undergoing clinically indicated HCR and multivessel PCI for hybrid-eligible coronary artery disease, to inform the design of a confirmatory comparative effectiveness trial...
July 26, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27385425/dietary-nitrate-and-the-epidemiology-of-cardiovascular-disease-report-from-a-national-heart-lung-and-blood-institute-workshop
#14
Amrita Ahluwalia, Mark Gladwin, Gary D Coleman, Norman Hord, George Howard, Daniel B Kim-Shapiro, Martin Lajous, Filip J Larsen, David J Lefer, Leslie A McClure, Bernard T Nolan, Ryszard Pluta, Alan Schechter, Chia-Yih Wang, Mary H Ward, Jane L Harman
No abstract text is available yet for this article.
July 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27371352/maternal-dietary-intake-during-pregnancy-and-offspring-body-composition-the-healthy-start-study
#15
Tessa L Crume, John T Brinton, Allison Shapiro, Jill Kaar, Deborah H Glueck, Anna Maria Siega-Riz, Dana Dabelea
BACKGROUND: Consistent evidence of an influence of maternal dietary intake during pregnancy on infant body size and composition in human populations is lacking, despite robust evidence in animal models. OBJECTIVE: To evaluate the influence of maternal macronutrient intake and balance during pregnancy on neonatal body size and composition, including fat mass and fat free mass. STUDY DESIGN: The analysis was conducted among 1040 mother-offspring pairs enrolled in the prospective pre-birth observational cohort: The Healthy Start Study...
June 28, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27355784/peer-support-for-clinicians-a-programmatic-approach
#16
Jo Shapiro, Pamela Galowitz
Burnout is plaguing the culture of medicine and is linked to several primary causes including long work hours, increasingly burdensome documentation, and resource constraints. Beyond these, additional emotional stressors for physicians are involvement in an adverse event, especially one that involves a medical error, and malpractice litigation. The authors argue that it is imperative that health care institutions devote resources to programs that support physician well-being and resilience. Doing so after adverse and other emotionally stressful events, such as the death of a colleague or caring for victims of a mass trauma, is crucial as clinicians are often at their most vulnerable during such times...
September 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/27265921/the-use-of-an-indwelling-catheter-protocol-to-reduce-rates-of-postoperative-urinary-tract-infections
#17
Affan Umer, David S Shapiro, Chris Hughes, Cynthia Ross-Richardson, Scott Ellner
BACKGROUND: Catheter-associated urinary tract infections (CAUTI) have been associated with increases in morbidity and mortality as well as increased costs of hospitalization. At our institution, we implemented a protocol for indwelling catheter use, maintenance, and removal based on Center for Medicare and Medicaid Services (CMS) guidelines, in efforts to reduce CAUTI rates. METHODS: A hospital committee of quality stewards focused on several measures which included staff education, modification of existing systems to ensure compliance, and auditing of patient care areas for catheter utilization before implementation of the protocol...
April 2016: Connecticut Medicine
https://www.readbyqxmd.com/read/27114966/posterior-spinal-artery-aneurysm-presenting-with-leukocytoclastic-vasculitis
#18
Travis C Hill, Omar Tanweer, Cheddhi Thomas, John Engler, Maksim Shapiro, Tibor Becske, Paul P Huang
Rupture of isolated posterior spinal artery (PSA) aneurysms is a rare cause of subarachnoid hemorrhage (SAH) that presents unique diagnostic challenges owing to a nuanced clinical presentation. Here, we report on the diagnosis and management of the first known case of an isolated PSA aneurysm in the context of leukocytoclastic vasculitis. A 53-year-old male presented to an outside institution with acute bilateral lower extremity paralysis 9 days after admission for recurrent cellulitis. Early magnetic resonance imaging was read as negative and repeat imaging 15 days after presentation revealed SAH and a compressive spinal subdural hematoma...
March 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27105409/arsenic-from-community-water-fluoridation-quantifying-the-effect
#19
Emily Peterson, Howard Shapiro, Ye Li, John G Minnery, Ray Copes
Community water fluoridation is a WHO recommended strategy to prevent dental carries. One debated concern is that hydrofluorosilicic acid, used to fluoridate water, contains arsenic and poses a health risk. This study was undertaken to determine if fluoridation contributes to arsenic in drinking water, to estimate the amount of additional arsenic associated with fluoridation, and compare this to the National Sanitation Foundation/American National Standards Institute (NSF/ANSI) standard and estimates from other researchers...
April 2016: Journal of Water and Health
https://www.readbyqxmd.com/read/27097299/nail-alterations-during-pregnancy-a-clinical-study
#20
Seval Erpolat, Ayla Eser, Ikbal Kaygusuz, Hatice Balci, Aydin Kosus, Nermin Kosus
During pregnancy, cutaneous and appendageal alterations manifest and may cause concern in the subject. The nails may be affected by pregnancy. This study investigated the frequency and nature of nail changes occurring during pregnancy in 312 healthy, 18-40-year-old pregnant women in gestation weeks 16-40. After a routine obstetric examination at the obstetrics and gynecology clinic at the study institution, all subjects submitted to an examination of all fingernails and toenails. Only nail alterations that had developed during pregnancy were recorded...
October 2016: International Journal of Dermatology
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