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https://www.readbyqxmd.com/read/29773080/adjuvant-ny-eso-1-vaccine-immunotherapy-in-high-risk-resected-melanoma-a-retrospective-cohort-analysis
#1
Michael Lattanzi, Joseph Han, Una Moran, Kierstin Utter, Jeremy Tchack, Rachel Lubong Sabado, Russell Berman, Richard Shapiro, Hsin-Hui Huang, Iman Osman, Nina Bhardwaj, Anna C Pavlick
BACKGROUND: Cancer-testis antigen NY-ESO-1 is a highly immunogenic melanoma antigen which has been incorporated into adjuvant vaccine clinical trials. Three such early-phase trials were conducted at our center among patients with high-risk resected melanoma. We herein report on the pooled long-term survival outcomes of these patients in comparison to historical controls. METHODS: All melanoma patients treated at NYU Langone Health under any of three prospective adjuvant NY-ESO-1 vaccine trials were retrospectively pooled into a single cohort...
May 18, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29753517/liberal-versus-restrictive-intravenous-fluid-therapy-for-early-septic-shock-rationale-for-a-randomized-trial
#2
Wesley H Self, Matthew W Semler, Rinaldo Bellomo, Samuel M Brown, Bennett P deBoisblanc, Matthew C Exline, Adit A Ginde, Colin K Grissom, David R Janz, Alan E Jones, Kathleen D Liu, Stephen P J Macdonald, Chadwick D Miller, Pauline K Park, Lora A Reineck, Todd W Rice, Jay S Steingrub, Daniel Talmor, Donald M Yealy, Ivor S Douglas, Nathan I Shapiro
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approach for administering intravenous fluid in septic shock resuscitation is unknown. Two competing strategies are emerging: a liberal fluids approach, consisting of a larger volume of initial fluid (50 to 75 mL/kg [4 to 6 L in an 80-kg adult] during the first 6 hours) and later use of vasopressors, versus a restrictive fluids approach, consisting of a smaller volume of initial fluid (≤30 mL/kg [≤2 to 3 L]), with earlier reliance on vasopressor infusions to maintain blood pressure and perfusion...
May 9, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29694825/birth-outcomes-for-pregnant-women-with-hiv-using-tenofovir-emtricitabine
#3
COMPARATIVE STUDY
Kathryn Rough, George R Seage, Paige L Williams, Sonia Hernandez-Diaz, Yanling Huo, Ellen G Chadwick, Judith S Currier, Risa M Hoffman, Emily Barr, David E Shapiro, Kunjal Patel
BACKGROUND: In a previous trial of antiretroviral therapy (ART) involving pregnant women with human immunodeficiency virus (HIV) infection, those randomly assigned to receive tenofovir, emtricitabine, and ritonavir-boosted lopinavir (TDF-FTC-LPV/r) had infants at greater risk for very premature birth and death within 14 days after delivery than those assigned to receive zidovudine, lamivudine, and ritonavir-boosted lopinavir (ZDV-3TC-LPV/r). METHODS: Using data from two U...
April 26, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29659475/frailty-screening-and-a-frailty-pathway-decrease-length-of-stay-loss-of-independence-and-30-day-readmission-rates-in-frail-geriatric-trauma-and-emergency-general-surgery-patients
#4
Kathryn E Engelhardt, Quentin Reuter, Jessica Liu, Jonathan F Bean, Joliette Barnum, Michael B Shapiro, Allison Ambre, Amanda Dunbar, Mara Markzon, Tara Reddy, Christine Schilling, Joseph Posluszny
BACKGROUND: Frail geriatric trauma and emergency general surgery (TEGS) patients have longer lengths of stay (LOS), more readmissions, and higher rates of post-discharge institutionalization than their non-frail counterparts. Despite calls to action by national trauma coalitions, there are few published reports of prospective interventions. The objective of this quality improvement (QI) project was to first develop a frailty screening program, and, then, if frail, implement a novel Frailty Pathway to reduce LOS, 30-day readmissions, and loss of independence (LOI)...
April 13, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29628939/permanent-deployment-of-the-solitaire-fr%C3%A2-device-in-the-basilar-artery-in-an-acute-stroke-scenario
#5
Miguel S Litao, Erez Nossek, Keith DeSousa, Albert Favate, Eytan Raz, Maksim Shapiro, Tibor Becske, Peter Kim Nelson
Background: Scarce reports exist of permanent deployment of Solitaire FR™ devices for arterial steno-occlusive disease as it is primarily indicated for temporary deployment for thrombectomy in large-vessel, anterior-circulation ischemic strokes. Even more scarce are reports describing permanent deployment of the Solitaire device for posterior circulation strokes. Summary: We present 2 cases where the Solitaire device was electrolytically detached to re-establish flow in an occluded or stenotic basilar artery in acutely symptomatic patients...
February 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29625857/decrease-of-premature-mothers-stress-levels-in-the-intensive-care-unit
#6
B Villamizar-Carvajal, C Vargas-Porras, J R García-Corzo
OBJECTIVE: To determine the effectiveness of the 'Creating Opportunities for Parent Empowerment' (COPE) programme in reducing stress levels in mothers of preterm infants in the neonatal intensive care unit (NICU). METHODS: Clinical trial performed in Colombia, including mothers of infants younger than 34 weeks of gestation, hospitalized, without a history of premature delivery. The mothers with psychiatric illnesses, language disorders, history of use of psychoactive substances and whose newborns had a congenital malformation were excluded...
April 3, 2018: Enfermería Intensiva
https://www.readbyqxmd.com/read/29579509/a-comparison-of-aggression-and-self-injury-among-type-1-diabetic-and-healthy-adolescents-a-sample-from-turkey
#7
Yagmur Sezer Efe, Emine Erdem
BACKGROUND: Adolescents tend to have risky behaviors like aggression and self-injury due to the age period characteristics. The risk of aggression and self-injury may increase in adolescents with the addition of chronic diseases. OBJECTIVES: This study was conducted descriptively to determine and compare the aggression and self-injury in those with type 1 diabetes mellitus (T1DM) and healthy counterparts. METHODS: The study sample consisted of 60 adolescents with T1DM followed up in the child endocrinology polyclinic of a university hospital and 319 healthy counterparts, 15-18 aged, at 9th-12th grade at high school...
April 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29445030/cabozantinib-in-patients-with-advanced-merkel-cell-carcinoma
#8
Guilherme Rabinowits, Cecilia Lezcano, Paul J Catalano, Patricia McHugh, Hailey Becker, Megan M Reilly, Julian Huang, Ayushi Tyagi, Manisha Thakuria, Scott C Bresler, Lynette M Sholl, Geoffrey I Shapiro, Robert Haddad, James A DeCaprio
BACKGROUND: This study sought to determine the efficacy and safety profile of cabozantinib in patients with advanced Merkel cell carcinoma (MCC). EXPERIMENTAL DESIGN: This prospective, phase II, single-institution trial enrolled patients with platinum-failure, recurrent/metastatic MCC to receive cabozantinib 60 mg orally daily until disease progression, withdrawal from study, or severe toxicity. The primary endpoint was disease control rate. Secondary endpoints included overall survival (OS), progression-free survival (PFS), and toxicity...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29404850/mabal-a-novel-deep-learning-architecture-for-machine-assisted-bone-age-labeling
#9
Simukayi Mutasa, Peter D Chang, Carrie Ruzal-Shapiro, Rama Ayyala
Bone age assessment (BAA) is a commonly performed diagnostic study in pediatric radiology to assess skeletal maturity. The most commonly utilized method for assessment of BAA is the Greulich and Pyle method (Pediatr Radiol 46.9:1269-1274, 2016; Arch Dis Child 81.2:172-173, 1999) atlas. The evaluation of BAA can be a tedious and time-consuming process for the radiologist. As such, several computer-assisted detection/diagnosis (CAD) methods have been proposed for automation of BAA. Classical CAD tools have traditionally relied on hard-coded algorithmic features for BAA which suffer from a variety of drawbacks...
February 5, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29397354/napabucasin-versus-placebo-in-refractory-advanced-colorectal-cancer-a-randomised-phase-3-trial
#10
Derek J Jonker, Louise Nott, Takayuki Yoshino, Sharlene Gill, Jeremy Shapiro, Atsushi Ohtsu, John Zalcberg, Michael M Vickers, Alice C Wei, Yuan Gao, Niall C Tebbutt, Ben Markman, Timothy Price, Taito Esaki, Sheryl Koski, Matthew Hitron, Wei Li, Youzhi Li, Nadine M Magoski, Chiang J Li, John Simes, Dongsheng Tu, Christopher J O'Callaghan
BACKGROUND: Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3, which is a poor prognostic factor in colorectal cancer. This study aimed to test napabucasin in advanced colorectal cancer. METHODS: This study was a double-blind randomised phase 3 trial done at 68 centres in Canada, Australia, New Zealand, and Japan. Patients with advanced colorectal cancer with a good Eastern Cooperative Oncology Group (ECOG) performance status (0-1) for whom all available standard therapies had failed were eligible for the study...
April 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29382773/spinal-artery-aneurysms-clinical-presentation-radiological-findings-and-outcome
#11
Leonardo Renieri, Eytan Raz, Giuseppe Lanzino, Timo Krings, Maksim Shapiro, Peyman Shirani, Waleed Brinjikji
BACKGROUND AND PURPOSE: Spinal arterial aneurysms are a rare cause of spinal subarachnoid hemorrhage (SAH). We performed a retrospective review of spinal arterial aneurysms not associated with spinal arteriovenus shunts from three institutions in order to better understand the clinical and imaging characteristics of these lesions. MATERIALS AND METHODS: We performed a retrospective review of spinal arterial aneurysms managed at three North American institutions...
January 30, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29329100/a-web-based-system-for-bayesian-benchmark-dose-estimation
#12
Kan Shao, Andrew J Shapiro
BACKGROUND: Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; therefore, a reliable tool is needed to provide distributional estimates for BMD and other important quantities in dose-response assessment. OBJECTIVES: We developed an online system for Bayesian BMD (BBMD) estimation and compared results from this software with U...
January 11, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29239954/analysis-of-inpatient-falls-after-total-knee-arthroplasty-in-patients-with-continuous-femoral-nerve-block
#13
Lloyd R Turbitt, Paul G McHardy, Michel Casanova, Joel Shapiro, Lisa Li, Stephen Choi
Continuous femoral nerve block (cFNB) is thought to increase the risk of falls after total knee arthroplasty (TKA). Previous studies have failed to consider the timing of cFNB removal in relation to inpatient falls. We investigated all inpatient falls after TKA over a 3-year period using our institutional safety report database. Ninety-five falls were reported from a total of 3745 patients. The frequency of falls after TKA persisted at a similar rate despite removal of cFNB and likely regression of femoral nerve block...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29235988/optimal-transformations-leading-to-normal-distributions-of-positron-emission-tomography-standardized-uptake-values
#14
Matthew Scarpelli, Jens Eickhoff, Enrique Cuna, Scott Perlman, Robert Jeraj
The statistical analysis of positron emission tomography (PET) standardized uptake value (SUV) measurements is challenging due to the skewed nature of SUV distributions. This limits utilization of powerful parametric statistical models for analyzing SUV measurements. An ad-hoc approach, which is frequently used in practice, is to blindly use a log transformation, which may or may not result in normal SUV distributions. This study sought to identify optimal transformations leading to normally distributed PET SUVs extracted from tumors and assess the effects of therapy on the optimal transformations...
January 30, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29099565/implementation-of-an-enhanced-recovery-after-surgery-program-for-colorectal-surgery-at-a-community-teaching-hospital
#15
Mallory S Bray, Angela L Appel, Kara J Kallies, Andrew J Borgert, Brittany A Zinnel, Stephen B Shapiro
INTRODUCTION: Perioperative programs aimed at decreasing surgical stress to colorectal patients can reduce hospital length of stay and morbidity while improving the patient’s perception of the surgical experience. Our goal was to transform patient care from a perioperative platform based on individual physician and nurse choice to a standardized evidence-based Enhanced Recovery After Surgery (ERAS) protocol for all patients undergoing elective colorectal resections. METHODS: An institutional review board-approved retrospective review was performed for the first 12 months of ERAS protocol-driven patient care in 2014 and compared to the prior 12 months (2013) of individual choice managed care...
February 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29098423/hypoglycemia-reduction-strategies-in-the-icu
#16
REVIEW
Susan Shapiro Braithwaite, Dharmesh B Bavda, Thaer Idrees, Faisal Qureshi, Oluwakemi T Soetan
PURPOSE OF REVIEW: We reviewed the strategies associated with hypoglycemia risk reduction among critically ill non-pregnant adult patients. RECENT FINDINGS: Hypoglycemia in the ICU has been associated with increased mortality in a number of studies. Insulin dosing and glucose monitoring rules, response to impending hypoglycemia, use of computerization, and attention to modifiable factors extrinsic to insulin algorithms may affect the risk for hypoglycemia. Recurring use of intravenous (IV) bolus doses of insulin in insulin-resistant cases may reduce reliance upon higher IV infusion rates...
November 2, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/29064510/biomolecular-computers-with-multiple-restriction-enzymes
#17
Sebastian Sakowski, Tadeusz Krasinski, Jacek Waldmajer, Joanna Sarnik, Janusz Blasiak, Tomasz Poplawski
The development of conventional, silicon-based computers has several limitations, including some related to the Heisenberg uncertainty principle and the von Neumann "bottleneck". Biomolecular computers based on DNA and proteins are largely free of these disadvantages and, along with quantum computers, are reasonable alternatives to their conventional counterparts in some applications. The idea of a DNA computer proposed by Ehud Shapiro's group at the Weizmann Institute of Science was developed using one restriction enzyme as hardware and DNA fragments (the transition molecules) as software and input/output signals...
October 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28912973/clinical-characteristics-in-patients-with-triple-negative-breast-cancer
#18
Janet Yeh, Jennifer Chun, Shira Schwartz, Annie Wang, Elizabeth Kern, Amber A Guth, Deborah Axelrod, Richard Shapiro, Freya Schnabel
PURPOSE: The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. METHODS: Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016. RESULTS: Out of a total of 1964 patients, 190 (10%) patients had TNBC...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28835200/research-productivity-of-doctor-of-physical-therapy-faculty-promoted-in-the-southeastern-united-states
#19
Marissa A Littman, James W Sonne, Gerald V Smith
BACKGROUND: Little information exists on the research productivity of successfully promoted tenure-track Doctor of Physical Therapy (DPT) faculty. OBJECTIVE: To determine the research productivity that typically results in successful promotion. DESIGN: We collected publicly available curriculum vitae (CVs) from faculty currently in accredited DPT programs and who had been successfully promoted from an institution in the southeastern USA from 2000 through 2016...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28807752/vasectomy-practice-patterns-among-family-medicine-physicians-and-compliance-with-the-american-urological-association-2012-vasectomy-guidelines
#20
Daniel D Shapiro, Sandra A Kamnetz, Brian V Le
OBJECTIVE: To survey urologists and family medicine physicians (FMPs) within a single institution to determine current vasectomy practice patterns and determine compliance with 2012 American Urological Association (AUA) vasectomy guidelines. METHODS: In 2016, a single-institution survey was conducted to understand the vasectomy practice patterns among urologists and nonurologists. The survey questions and 3 clinical scenarios were designed based on the 2012 AUA vasectomy guidelines...
November 2017: Urology
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