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shapiro institute

Emily Denise Melton, Dimitry Y Sorokin, Lex Overmars, Olga Chertkov, Alicia Clum, Manoj Pillay, Natalia Ivanova, Nicole Shapiro, Nikos C Kyrpides, Tanja Woyke, Alla L Lapidus, Gerard Muyzer
Desulfurivibrio alkaliphilus strain AHT2(T) is a strictly anaerobic sulfidogenic haloalkaliphile isolated from a composite sediment sample of eight hypersaline alkaline lakes in the Wadi al Natrun valley in the Egyptian Libyan Desert. D. alkaliphilus AHT2(T) is Gram-negative and belongs to the family Desulfobulbaceae within the Deltaproteobacteria. Here we report its genome sequence, which contains a 3.10 Mbp chromosome. D. alkaliphilus AHT2(T) is adapted to survive under highly alkaline and moderately saline conditions and therefore, is relevant to the biotechnology industry and life under extreme conditions...
2016: Standards in Genomic Sciences
Ganesh Narayanasamy, Sotirios Stathakis, Alonso N Gutierrez, Evangelos Pappas, Richard Crownover, John R Floyd, Niko Papanikolaou
BACKGROUND: In this treatment planning study, we compare the plan quality and delivery parameters for the treatment of multiple brain metastases using 2 monoisocentric techniques: the Multiple Metastases Element from Brainlab and the RapidArc volumetric-modulated arc therapy from Varian Medical Systems. METHODS: Eight patients who were treated in our institution for multiple metastases (3-7 lesions) were replanned with Multiple Metastases Element using noncoplanar dynamic conformal arcs...
September 9, 2016: Technology in Cancer Research & Treatment
Alla Keyzner, Sarah Han, Samantha Shapiro, Erin Moshier, Emily Schorr, Bruce Petersen, Vesna Najfeld, Marina Kremyanskaya, Luis Isola, Ronald Hoffman, John Mascarenhas
Myelofibrosis (MF) is a chronic progressive hematologic malignancy with a median overall survival (OS) of approximately 6 years. Allogeneic hematopoietic stem cell transplantation (HSCT) is the sole treatment approach that offers curative potential. The use of reduced-intensity conditioning regimens has expanded the application of HSCT to patients with MF up to age 70 years. Recent retrospective and prospective reports have suggested worse HSCT outcomes for patients with MF receiving an unrelated donor graft compared with those receiving a related donor graft...
September 3, 2016: Biology of Blood and Marrow Transplantation
Dong W Chang, Martin F Shapiro
Importance: Maximizing the value of critical care services requires understanding the relationship between intensive care unit (ICU) utilization, clinical outcomes, and costs. Objective: To examine whether hospitals had consistent patterns of ICU utilization across 4 common medical conditions and the association between higher use of the ICU and hospital costs, use of invasive procedures, and mortality. Design, Setting, and Participants: Retrospective cohort study of 156 842 hospitalizations in 94 acute-care nonfederal hospitals for diabetic ketoacidosis (DKA), pulmonary embolism (PE), upper gastrointestinal bleeding (UGIB), and congestive heart failure (CHF) in Washington state and Maryland from 2010 to 2012...
October 1, 2016: JAMA Internal Medicine
Marlen C Rice, Jeanette M Norton, Frederica Valois, Annette Bollmann, Peter J Bottomley, Martin G Klotz, Hendrikus J Laanbroek, Yuichi Suwa, Lisa Y Stein, Luis Sayavedra-Soto, Tanja Woyke, Nicole Shapiro, Lynne A Goodwin, Marcel Huntemann, Alicia Clum, Manoj Pillay, Nikos Kyrpides, Neha Varghese, Natalia Mikhailova, Victor Markowitz, Krishna Palaniappan, Natalia Ivanova, Dimitrios Stamatis, T B K Reddy, Chew Yee Ngan, Chris Daum
Nitrosospira briensis C-128 is an ammonia-oxidizing bacterium isolated from an acid agricultural soil. N. briensis C-128 was sequenced with PacBio RS technologies at the DOE-Joint Genome Institute through their Community Science Program (2010). The high-quality finished genome contains one chromosome of 3.21 Mb and no plasmids. We identified 3073 gene models, 3018 of which are protein coding. The two-way average nucleotide identity between the chromosomes of Nitrosospira multiformis ATCC 25196 and Nitrosospira briensis C-128 was found to be 77...
2016: Standards in Genomic Sciences
John D Puskas, Michael E Halkos, Joseph J DeRose, Emilia Bagiella, Marissa A Miller, Jessica Overbey, Johannes Bonatti, V S Srinivas, Mark Vesely, Francis Sutter, Janine Lynch, Katherine Kirkwood, Timothy A Shapiro, Konstantinos D Boudoulas, Juan Crestanello, Thomas Gehrig, Peter Smith, Michael Ragosta, Steven J Hoff, David Zhao, Annetine C Gelijns, Wilson Y Szeto, Giora Weisz, Michael Argenziano, Thomas Vassiliades, Henry Liberman, William Matthai, Deborah D Ascheim
BACKGROUND: Hybrid coronary revascularization (HCR) combines minimally invasive surgical coronary artery bypass grafting of the left anterior descending artery with percutaneous coronary intervention (PCI) of non-left anterior descending vessels. HCR is increasingly used to treat multivessel coronary artery disease that includes stenoses in the proximal left anterior descending artery and at least 1 other vessel, but its effectiveness has not been rigorously evaluated. OBJECTIVES: This National Institutes of Health-funded, multicenter, observational study was conducted to explore the characteristics and outcomes of patients undergoing clinically indicated HCR and multivessel PCI for hybrid-eligible coronary artery disease, to inform the design of a confirmatory comparative effectiveness trial...
July 26, 2016: Journal of the American College of Cardiology
Amrita Ahluwalia, Mark Gladwin, Gary D Coleman, Norman Hord, George Howard, Daniel B Kim-Shapiro, Martin Lajous, Filip J Larsen, David J Lefer, Leslie A McClure, Bernard T Nolan, Ryszard Pluta, Alan Schechter, Chia-Yih Wang, Mary H Ward, Jane L Harman
No abstract text is available yet for this article.
July 2016: Journal of the American Heart Association
Tessa L Crume, John T Brinton, Allison Shapiro, Jill Kaar, Deborah H Glueck, Anna Maria Siega-Riz, Dana Dabelea
BACKGROUND: Consistent evidence of an influence of maternal dietary intake during pregnancy on infant body size and composition in human populations is lacking, despite robust evidence in animal models. OBJECTIVE: To evaluate the influence of maternal macronutrient intake and balance during pregnancy on neonatal body size and composition, including fat mass and fat free mass. STUDY DESIGN: The analysis was conducted among 1040 mother-offspring pairs enrolled in the prospective pre-birth observational cohort: The Healthy Start Study...
June 28, 2016: American Journal of Obstetrics and Gynecology
Jo Shapiro, Pamela Galowitz
Burnout is plaguing the culture of medicine and is linked to several primary causes including long work hours, increasingly burdensome documentation, and resource constraints. Beyond these, additional emotional stressors for physicians are involvement in an adverse event, especially one that involves a medical error, and malpractice litigation. The authors argue that it is imperative that health care institutions devote resources to programs that support physician well-being and resilience. Doing so after adverse and other emotionally stressful events, such as the death of a colleague or caring for victims of a mass trauma, is crucial as clinicians are often at their most vulnerable during such times...
September 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Affan Umer, David S Shapiro, Chris Hughes, Cynthia Ross-Richardson, Scott Ellner
BACKGROUND: Catheter-associated urinary tract infections (CAUTI) have been associated with increases in morbidity and mortality as well as increased costs of hospitalization. At our institution, we implemented a protocol for indwelling catheter use, maintenance, and removal based on Center for Medicare and Medicaid Services (CMS) guidelines, in efforts to reduce CAUTI rates. METHODS: A hospital committee of quality stewards focused on several measures which included staff education, modification of existing systems to ensure compliance, and auditing of patient care areas for catheter utilization before implementation of the protocol...
April 2016: Connecticut Medicine
Travis C Hill, Omar Tanweer, Cheddhi Thomas, John Engler, Maksim Shapiro, Tibor Becske, Paul P Huang
Rupture of isolated posterior spinal artery (PSA) aneurysms is a rare cause of subarachnoid hemorrhage (SAH) that presents unique diagnostic challenges owing to a nuanced clinical presentation. Here, we report on the diagnosis and management of the first known case of an isolated PSA aneurysm in the context of leukocytoclastic vasculitis. A 53-year-old male presented to an outside institution with acute bilateral lower extremity paralysis 9 days after admission for recurrent cellulitis. Early magnetic resonance imaging was read as negative and repeat imaging 15 days after presentation revealed SAH and a compressive spinal subdural hematoma...
March 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
Emily Peterson, Howard Shapiro, Ye Li, John G Minnery, Ray Copes
Community water fluoridation is a WHO recommended strategy to prevent dental carries. One debated concern is that hydrofluorosilicic acid, used to fluoridate water, contains arsenic and poses a health risk. This study was undertaken to determine if fluoridation contributes to arsenic in drinking water, to estimate the amount of additional arsenic associated with fluoridation, and compare this to the National Sanitation Foundation/American National Standards Institute (NSF/ANSI) standard and estimates from other researchers...
April 2016: Journal of Water and Health
Seval Erpolat, Ayla Eser, Ikbal Kaygusuz, Hatice Balci, Aydin Kosus, Nermin Kosus
During pregnancy, cutaneous and appendageal alterations manifest and may cause concern in the subject. The nails may be affected by pregnancy. This study investigated the frequency and nature of nail changes occurring during pregnancy in 312 healthy, 18-40-year-old pregnant women in gestation weeks 16-40. After a routine obstetric examination at the obstetrics and gynecology clinic at the study institution, all subjects submitted to an examination of all fingernails and toenails. Only nail alterations that had developed during pregnancy were recorded...
October 2016: International Journal of Dermatology
Samir R Jani, Fred E Shapiro, Rodney A Gabriel, Hubert Kordylewski, Richard P Dutton, Richard D Urman
Ambulatory and office-based surgery is expanding rapidly. While growth continues, there are lingering patient safety concerns. To this end, the American Society of Anesthesiologists (ASA) created the Anesthesia Quality Institute (AQI), which collected patient and procedural characteristics on 23,341,130 anesthetics from all health care settings from 2010 to 2014. Of these, 179,618 office and 4,627,379 ambulatory cases were isolated and compared. Our findings show that although both settings are often grouped together, there are statistically significant differences in patient demographics, procedure types, and reported adverse events...
April 2016: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
J Peter Campbell, Esra Ataer-Cansizoglu, Veronica Bolon-Canedo, Alican Bozkurt, Deniz Erdogmus, Jayashree Kalpathy-Cramer, Samir N Patel, James D Reynolds, Jason Horowitz, Kelly Hutcheson, Michael Shapiro, Michael X Repka, Phillip Ferrone, Kimberly Drenser, Maria Ana Martinez-Castellanos, Susan Ostmo, Karyn Jonas, R V Paul Chan, Michael F Chiang
IMPORTANCE: Published definitions of plus disease in retinopathy of prematurity (ROP) reference arterial tortuosity and venous dilation within the posterior pole based on a standard published photograph. One possible explanation for limited interexpert reliability for a diagnosis of plus disease is that experts deviate from the published definitions. OBJECTIVE: To identify vascular features used by experts for diagnosis of plus disease through quantitative image analysis...
June 1, 2016: JAMA Ophthalmology
Babak J Orandi, Xun Luo, Allan B Massie, Jacqueline M Garonzik-Wang, Bonne E Lonze, Rizwan Ahmed, Kyle J Van Arendonk, Mark D Stegall, Stanley C Jordan, Jose Oberholzer, Ty B Dunn, Lloyd E Ratner, Sandip Kapur, Ronald P Pelletier, John P Roberts, Marc L Melcher, Pooja Singh, Debra L Sudan, Marc P Posner, Jose M El-Amm, Ron Shapiro, Matthew Cooper, George S Lipkowitz, Michael A Rees, Christopher L Marsh, Bashir R Sankari, David A Gerber, Paul W Nelson, Jason Wellen, Adel Bozorgzadeh, A Osama Gaber, Robert A Montgomery, Dorry L Segev
BACKGROUND: A report from a high-volume single center indicated a survival benefit of receiving a kidney transplant from an HLA-incompatible live donor as compared with remaining on the waiting list, whether or not a kidney from a deceased donor was received. The generalizability of that finding is unclear. METHODS: In a 22-center study, we estimated the survival benefit for 1025 recipients of kidney transplants from HLA-incompatible live donors who were matched with controls who remained on the waiting list or received a transplant from a deceased donor (waiting-list-or-transplant control group) and controls who remained on the waiting list but did not receive a transplant (waiting-list-only control group)...
March 10, 2016: New England Journal of Medicine
Jason M Shapiro, Helga Zoega, Samir A Shah, Renee M Bright, Meaghan Mallette, Heather Moniz, Stacey A Grabert, Barbara Bancroft, Marjorie Merrick, Nicole T Flowers, Zahid Samad, Sheldon Lidofsky, Neal S LeLeiko, Bruce E Sands
BACKGROUND: Studies describing the incidence of Crohn's disease (CD) and ulcerative colitis (UC) are uncommon in the United States. We sought to determine the incidence of CD and UC in the state of Rhode Island. METHODS: The Ocean State Crohn's and Colitis Area Registry is a state-based inception cohort of patients newly diagnosed with inflammatory bowel disease (IBD) in Rhode Island. To confirm a diagnosis of CD, UC, or IBD unclassified (IBDU), the National Institute of Diabetes and Digestive and Kidney Diseases IBD Genetics Consortium criteria were applied in a review of medical records from gastroenterology practices located in the state of Rhode Island and adjacent to the Rhode Island border in Massachusetts and Connecticut...
June 2016: Inflammatory Bowel Diseases
Amir H Davarpanah, Michael Spektor, Mahan Mathur, Gary M Israel
Purpose To retrospectively determine if homogeneous high T1 signal intensity (SI) masses with smooth borders on unenhanced magnetic resonance (MR) images can be characterized as benign. Materials and Methods Institutional review board approval was obtained for this HIPAA-compliant retrospective study, with waiver of informed consent. MR images in 84 patients with hemorrhagic or proteinaceous cysts and 50 patients with renal cell carcinoma (RCC) were evaluated. Sixty-three cysts and 49 RCCs underwent unenhanced computed tomography (CT)...
July 2016: Radiology
Julia F Malalis, Pooja Bhat, Michael Shapiro, Debra A Goldstein
PURPOSE: To describe the course of retinoschisis in patients with pars planitis (PP). METHODS: Chart review of PP patients seen July 2012-September 2014 at a single institution. RESULTS: Included were 34 patients (68 eyes). Uveitis was bilateral in all cases. Thirteen eyes (19%) developed retinoschisis. In six patients (86%), the schisis was bilateral. The average follow-up of patients with schisis was 7 years; the average best-corrected visual acuity (BCVA) was 20/22 at last follow-up...
February 22, 2016: Ocular Immunology and Inflammation
Jung-In Kim, Jin-Beom Chung, Ju-Young Song, Sung Kyu Kim, Yunseok Choi, Chang Heon Choi, Won Hoon Choi, Byungchul Cho, Jin Sung Kim, Sung Jin Kim, Sung-Joon Ye
This study aims to investigate tolerance levels for patient-specific IMRT dose QA (DQA) using the confidence limits (CL) determined by a multi-institutional study. Eleven institutions participated in the multi-institutional study in Korea. A total of 155 DQA measurements, consisting of point-dose differences (high- and low-dose regions) and gamma passing rates (composite and per-field) for IMRT patients with brain, head and neck (H&N), abdomen, and prostate cancers were examined. The Shapiro-Wilk test was used to evaluate the normality of data grouped by the treatment sites and the DQA methods...
2016: Journal of Applied Clinical Medical Physics
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