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https://www.readbyqxmd.com/read/28627853/determinants-of-outbreaks-of-emerging-infectious-diseases-the-case-of-chikungunya-in-indian-ocean-2004-2007
#1
Antoine Flahault
Emerging outbreaks of arboviroses are most often tied to the convergence of a set of factors which have physical and environmental, genetic and biological, ecological, social, political and economic origins. Thirteen out of these factors are known as main determinants of emerging infectious disease outbreaks. This paper assesses the role of these factors from exploring the Chikungunya outbreak which occurred in Indian Ocean in 2004-2007, as case study. Chikungunya is an alphavirus borne and transmitted by Aedes aegypti and Aedes albopictus...
May 3, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28619679/antiviral-activity-of-1-2-3-triazolo-4-5-d-pyrimidin-7-6h-ones-against-chikungunya-virus-targeting-the-viral-capping-nsp1
#2
Alba Gigante, Asier Gómez-SanJuan, Leen Delang, C Li, Oskía Bueno, Ana María Gamo, Eva-María Priego, María-José Camarasa, Dirk Jochmans, Pieter Leyssen, Etienne Decroly, Bruno Coutard, Gilles Querat, Johan Neyts, María-Jesús Pérez-Pérez
Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted to humans by Aedes mosquitoes. Since 2005, CHIKV has been spreading worldwide resulting in epidemics in Africa, the Indian Ocean islands, Asia and more recently in the Americas. CHIKV is thus considered as a global health concern. There is no specific vaccine or drug available for the treatment of this incapacitating viral infection. We previously identified 3-aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as selective inhibitors of CHIKV replication and proposed the viral capping enzyme nsP1 as a target...
June 12, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28616473/ten-years-of-the-tiger-aedes-albopictus-presence-in-australia-since-its-discovery-in-the-torres-strait-in-2005
#3
REVIEW
Andrew F van den Hurk, Jay Nicholson, Nigel W Beebe, Joe Davis, Odwell M Muzari, Richard C Russell, Gregor J Devine, Scott A Ritchie
The "Asian tiger mosquito", Aedes albopictus, is highly invasive, an aggressive biter and a major arbovirus vector. It is not currently present on mainland Australia despite being intercepted on numerous occasions at international ports and infesting the Torres Strait of Australia since at least 2004. In the current paper, we describe the invasion and current status of Ae. albopictus in the Torres Strait, as well as research conducted to assess the threat of this species becoming established in arbovirus transmission cycles on the Australian mainland...
December 2016: One Health
https://www.readbyqxmd.com/read/28609439/interventions-for-treating-patients-with-chikungunya-virus-infection-related-rheumatic-and-musculoskeletal-disorders-a-systematic-review
#4
Arturo Martí-Carvajal, Pilar Ramon-Pardo, Emilie Javelle, Fabrice Simon, Sylvain Aldighieri, Hacsi Horvath, Julia Rodriguez-Abreu, Ludovic Reveiz
BACKGROUND: Chikungunya virus infection (CHIKV) is caused by a mosquito-borne alphavirus. CHIKV causes high fever and painful rheumatic disorders that may persist for years. Because little is known about interventions for treating CHIKV-related illness, we conducted a systematic review. METHODS: We used Cochrane methods. We searched PubMed, EMBASE, Cochrane Library, LILACS and other sources from the earliest records to March 2016. We had no language restrictions...
2017: PloS One
https://www.readbyqxmd.com/read/28606643/diagnostic-accuracy-of-a-rapid-e1-antigen-test-for-chikungunya-virus-infection-in-a-reference-setting
#5
Ralph Huits, Tamaki Okabayashi, Lieselotte Cnops, Barbara Barbé, Riemsdijk Van Den Berg, Koen Bartholomeeusen, Kevin K Ariën, Jan Jacobs, Emmanuel Bottieau, Emi E Nakayama, Tatsuo Shioda, Marjan Van Esbroeck
OBJECTIVES: Rapid diagnostic tests targeting virus-specific antigen could significantly enhance the diagnostic capacity for chikungunya virus infections. We evaluated the accuracy of an immunochromatographic antigen test for the diagnosis of chikungunya in a reference laboratory for arboviruses. METHODS: an immunochromatographic rapid test that uses mouse monoclonal antibodies as a tracer against the E1-envelope protein of chikungunya (ARKRAY, Inc. Kyoto, Japan) was evaluated...
June 9, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28577289/immunoglobulin-responsive-chikungunya-encephalitis-two-case-reports
#6
Stephanie Suzanne de O Scott, Pedro Braga-Neto, Lícia Pacheco Pereira, Paulo Ribeiro Nóbrega, Francisco de Assis Aquino Gondim, Manoel Alves Sobreira-Neto, Claudia Carvalho Mendes Schiavon
Chikungunya virus is an alphavirus transmitted by the mosquito Aedes, mainly Aedes aegypti and Aedes albopictus, that can cause acute illness, mostly self-limited, characterized by fever, maculopapular rash, and disabling polyarthritis/arthralgia, with an incubation period of 1 to 12 days. Chikungunya was largely regarded as a non-fatal and self-limited disease, but recently, serious cases have been reported including some with severe involvement of the nervous system, such as meningoencephalitis, myelitis, polyradiculitis, and polyradiculoneuropathy...
June 2, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28576570/deinococcus-mn-2-peptide-complex-a-novel-approach-to-alphavirus-vaccine-development
#7
Manoshi Gayen, Paridhi Gupta, Elaine M Morazzani, Elena K Gaidamakova, Barbara Knollmann-Ritschel, Michael J Daly, Pamela J Glass, Radha K Maheshwari
Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, on the other hand, has been developed as a bioweapon in the past due to its ease of preparation, aerosol dispersion and high lethality in aerosolized form. Currently, there are no FDA approved vaccines against these viruses...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28557974/oncolytic-alphavirus-sfv-va7-efficiently-eradicates-subcutaneous-and-orthotopic-human-prostate-tumours-in-mice
#8
Miika Martikainen, Janne Ruotsalainen, Johanna Tuomela, Pirkko Härkönen, Magnus Essand, Jari Heikkilä, Ari Hinkkanen
BACKGROUND: Despite recent therapeutic and diagnostic advances, prostate cancer remains the second leading cause of cancer-related deaths among men in the Western world. Oncolytic viruses that replicate selectively in tumour cells represent a novel treatment candidate for these malignancies. METHODS: We analysed infectivity of avirulent Semliki Firest virus SFV-VA7 in human prostate cancer cell lines VCaP, LNCaP and 22Rv1 and in nonmalignant prostate epithelial cell line RWPE-1...
May 30, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28555542/rift-valley-fever-virus-strategies-for-maintenance-survival-and-vertical-transmission-in-mosquitoes
#9
Sarah Lumley, Daniel L Horton, Luis L M Hernandez-Triana, Nicholas Johnson, Anthony R Fooks, Roger Hewson
Rift Valley fever virus (RVFV) is a mosquito-borne arbovirus causing severe disease in humans and ruminants. Spread of RVFV out of Africa has raised concerns that it could emerge in Europe or the USA. Virus persistence is dependent on successful infection of, replication in, and transmission to susceptible vertebrate and invertebrate hosts, modulated by virus-host and vector-virus interactions. The principal accepted theory for the long-term maintenance of RVFV involves vertical transmission (VT) of virus to mosquito progeny, with the virus surviving long inter-epizootic periods within the egg...
May 30, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28531865/glutamine-antagonist-mediated-immune-suppression-decreases-pathology-but-delays-virus-clearance-in-mice-during-nonfatal-alphavirus-encephalomyelitis
#10
Victoria K Baxter, Rebecca Glowinski, Alicia M Braxton, Michelle C Potter, Barbara S Slusher, Diane E Griffin
Infection of weanling C57BL/6 mice with the TE strain of Sindbis virus (SINV) causes nonfatal encephalomyelitis associated with hippocampal-based memory impairment that is partially prevented by treatment with 6-diazo-5-oxo-l-norleucine (DON), a glutamine antagonist (Potter et al., J Neurovirol 21:159, 2015). To determine the mechanism(s) of protection, lymph node and central nervous system (CNS) tissues from SINV-infected mice treated daily for 1 week with low (0.3mg/kg) or high (0.6mg/kg) dose DON were examined...
May 19, 2017: Virology
https://www.readbyqxmd.com/read/28518022/high-frequency-of-mayaro-virus-igm-among-febrile-patients-central-brazil
#11
Sandra Brunini, Divânia Dias Silva França, Juliana Brasiel Silva, Leandro Nascimento Silva, Flúvia Pereira Amorim Silva, Mariana Spadoni, Giovanni Rezza
Mayaro virus (MAYV), an Aedes mosquito-borne alphavirus, is endemic to Brazil and other South America countries. We investigated dengue- and chikungunya-negative febrile patients visiting rural areas near Goiânia, Goiás, and found a high proportion (55%) of MAYV IgM. Our findings suggest the presence of highly endemic foci of MAYV in central Brazil.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28515133/development-of-a-novel-virus-like-particle-vaccine-platform-that-mimics-immature-form-of-alphavirus
#12
Akane Urakami, Atsuko Sakurai, Momoko Ishikawa, Moh Lan Yap, Yevel Flores-Garcia, Yasunari Haseda, Taiki Aoshi, Fidel P Zavala, Michael G Rossmann, Sachiko Kuno, Ryuji Ueno, Wataru Akahata
Virus-like particles (VLPs) are non-infectious multiprotein structures that are engineered to self-assemble from viral structural proteins. Here, we developed a novel VLP-based vaccine platform utilizing VLPs from the Chikungunya virus. We identified two regions within the envelope protein, a structural component of Chikungunya, where foreign antigens can be inserted without compromising VLP structure. Our VLP displays 480 copious copies of an inserted antigen on the VLP surface in a highly symmetric manner, thus capable of inducing strong immune responses against any inserted antigen...
May 17, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28504426/mosquito-distribution-in-a-saltmarsh-determinants-of-eggs-in-a-variable-environment
#13
Raylea Rowbottom, Scott Carver, Leon A Barmuta, Philip Weinstein, Geoff R Allen
Two saltmarsh mosquitoes dominate the transmission of Ross River virus (RRV, Togoviridae: Alphavirus), one of Australia's most prominent mosquito-borne diseases. Ecologically, saltmarshes vary in their structure, including habitat types, hydrological regimes, and diversity of aquatic fauna, all of which drive mosquito oviposition behavior. Understanding the distribution of vector mosquitoes within saltmarshes can inform early warning systems, surveillance, and management of vector populations. The aim of this study was to identify the distribution of Ae...
June 2017: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/28501330/virus-entry-and-replication-in-the-brain-precedes-blood-brain-barrier-disruption-during-intranasal-alphavirus-infection
#14
Matthew D Cain, Hamid Salimi, Yongfeng Gong, Lihua Yang, Samantha L Hamilton, James R Heffernan, Jianghui Hou, Mark J Miller, Robyn S Klein
Viral infections of the central nervous system (CNS) are often associated with blood-brain barrier (BBB) disruption, yet the impact of virus replication and immune cell recruitment on BBB integrity are incompletely understood. Using two-photon microscopy, we demonstrate that Venezuelan equine encephalitis virus (VEEV) strain TC83-GFP, a GFP expressing, attenuated strain with a G3A mutation within the 5' UTR that is associated with increased sensitivity to type I interferons (IFNs), does not directly impact BBB permeability...
July 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28493514/protective-effect-and-antibody-response-of-dna-vaccine-against-salmonid-alphavirus-3-sav3-in-atlantic-salmon
#15
C J Chang, J Gu, B Robertsen
This work reports the effect of two DNA vaccines against salmonid alphavirus 3 (SAV3) in Atlantic salmon. Presmolts were vaccinated by intramuscular injection of plasmids encoding the SAV3 structural polyprotein C-E3-E2-6K-E2 (pCSP), E2 only (pE2), or plasmid without insert (pcDNA3.3). E2 is expressed at the surface of cells transfected with pCSP and internally in cells transfected with pE2. A commercial vaccine based on inactivated SAV (NCPD) was used for comparison. At 10 weeks post-vaccination, only fish vaccinated with pCSP showed antibody against E2 and virus-neutralizing activity...
May 11, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28483796/imaging-of-viral-neuroinvasion-in-the-zebrafish-reveals-that-sindbis-and-chikungunya-viruses-favour-different-entry-routes
#16
Gabriella Passoni, Christelle Langevin, Nuno Palha, Bryan C Mounce, Valérie Briolat, Pierre Affaticati, Elodie De Job, Jean-Stéphane Joly, Marco Vignuzzi, Maria-Carla Saleh, Philippe Herbomel, Pierre Boudinot, Jean-Pierre Levraud
Alphaviruses, such as chikungunya (CHIKV) and Sindbis virus (SINV), are vector‑borne pathogens that cause acute illnesses in humans and are sometimes associated with neuropathies, especially in infants and elderly patients. Little is known about their entry mechanism in the central nervous system (CNS), even for SINV, which has been used extensively as a model for viral encephalopathies. We previously established a CHIKV infection model in the optically transparent zebrafish larva; here we describe a new SINV infection model in this host...
May 8, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28472924/identification-of-differentially-expressed-atlantic-salmon-mirnas-responding-to-salmonid-alphavirus-sav-infection
#17
Rune Andreassen, Nardos Tesfaye Woldemariam, Ine Østråt Egeland, Oleg Agafonov, Hilde Sindre, Bjørn Høyheim
BACKGROUND: MicroRNAs (miRNAs) control multiple biological processes including the innate immune responses by negative post-transcriptional regulation of gene expression. As there were no studies on the role(s) of miRNAs in viral diseases in Atlantic salmon, we aimed to identify miRNAs responding to salmonid alphavirus (SAV) infection. Their expression were studied at different time points post infection with SAV isolates associated with different mortalities. Furthermore, the genome sequences of the identified miRNAs were analysed to reveal putative cis-regulatory elements, and, finally, their putative target genes were predicted...
May 4, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28468889/hypervariable-domain-of-eastern-equine-encephalitis-virus-nsp3-redundantly-utilizes-multiple-cellular-proteins-for-replication-complex-assembly
#18
Ilya Frolov, Dal Young Kim, Maryna Akhrymuk, James A Mobley, Elena I Frolova
Eastern equine encephalitis virus (EEEV) is a representative member of the New World alphaviruses. It is pathogenic for a variety of vertebrate hosts, in which EEEV induces highly debilitating disease with frequent lethal outcome. Despite a significant public health threat, the molecular mechanism of EEEV replication and interaction with hosts is poorly understood. Our previously published data and those of other teams have demonstrated that hypervariable domains (HVDs) of alphavirus nsP3 protein interact with virus-specific host factors and play critical roles in assembly of viral replication complexes (vRCs)...
May 3, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28467475/correction-triploid-atlantic-salmon-salmo-salar-l-post-smolts-accumulate-prevalence-more-slowly-than-diploid-salmon-following-bath-challenge-with-salmonid-alphavirus-subtype-3
#19
Lindsey J Moore, Tom Ole Nilsen, Jiraporn Jarungsriapisit, Per Gunnar Fjelldal, Sigurd O Stefansson, Geir Lasse Taranger, Sonal Patel
[This corrects the article DOI: 10.1371/journal.pone.0175468.].
2017: PloS One
https://www.readbyqxmd.com/read/28462045/on-the-entry-of-an-emerging-arbovirus-into-host-cells-mayaro-virus-takes-the-highway-to-the-cytoplasm-through-fusion-with-early-endosomes-and-caveolae-derived-vesicles
#20
Carlos A M Carvalho, Jerson L Silva, Andréa C Oliveira, Andre M O Gomes
Mayaro virus (MAYV) is an emergent sylvatic alphavirus in South America, related to sporadic outbreaks of a chikungunya-like human febrile illness accompanied by severe arthralgia. Despite its high potential for urban emergence, MAYV is still an obscure virus with scarce information about its infection cycle, including the corresponding early events. Even for prototypical alphaviruses, the cell entry mechanism still has some rough edges to trim: although clathrin-mediated endocytosis is quoted as the putative route, alternative paths as distinct as direct virus genome injection through the cell plasma membrane seems to be possible...
2017: PeerJ
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