keyword
MENU ▼
Read by QxMD icon Read
search

alphaviruses

keyword
https://www.readbyqxmd.com/read/27920182/monoclonal-antibodies-as-prophylactic-and-therapeutic-agents-against-chikungunya-virus
#1
April M Clayton
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that is responsible for considerable epidemics worldwide and recently emerged in the Americas in 2013. CHIKV may cause long-lasting arthralgia after acute infection. With currently no licensed vaccines or antivirals, the design of effective therapies to prevent or treat CHIKV infection is of utmost importance and will be facilitated by increased understanding of the dynamics of chikungunya. In this article, monoclonal antibodies against CHIKV as viable prophylactic and therapeutic agents will be discussed...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27920181/chikungunya-virus-vaccines-viral-vector-based-approaches
#2
Katrin Ramsauer, Frédéric Tangy
In 2013, a major chikungunya virus (CHIKV) epidemic reached the Americas. In the past 2 years, >1.7 million people have been infected. In light of the current epidemic, with millions of people in North and South America at risk, efforts to rapidly develop effective vaccines have increased. Here, we focus on CHIKV vaccines that use viral-vector technologies. This group of vaccine candidates shares an ability to potently induce humoral and cellular immune responses by use of highly attenuated and safe vaccine backbones...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27920178/animal-models-of-chikungunya-virus-infection-and-disease
#3
Nicole N Haese, Rebecca M Broeckel, David W Hawman, Mark T Heise, Thomas E Morrison, Daniel N Streblow
Chikungunya virus (CHIKV) is a reemerging alphavirus that causes acute febrile illness and severe joint pain in humans. Although acute symptoms often resolve within a few days, chronic joint and muscle pain can be long lasting. In the last decade, CHIKV has caused widespread outbreaks of unprecedented scale in the Americas, Asia, and the Indian Ocean island regions. Despite these outbreaks and the continued expansion of CHIKV into new areas, mechanisms of chikungunya pathogenesis and disease are not well understood...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27920171/chikungunya-pathogenesis-from-the-clinics-to-the-bench
#4
Philippe Gasque, Marie Christine Jaffar Bandjee, Marcela Mercado Reyes, Diego Viasus
Chikungunya alphavirus has caused large epidemics worldwide and leads to acute incapacitating polyarthralgia. The inflammatory reaction over several days will drive robust innate and humoral responses essential to control the infection. Critically, fatal cases and mother-to-child transmission have also been described. Chikungunya can give rise to chronic musculoskeletal diseases, which can last for months to years, particularly in elderly individuals, and occasionally leads to seronegative rheumatoid arthritis-like pathologies...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27919709/evaluation-of-anti-zika-virus-activities-of-broad-spectrum-antivirals-and-nih-clinical-collection-compounds-using-a-cell-based-high-throughput-screen-assay
#5
Robert S Adcock, Yong-Kyu Chu, Jennifer E Golden, Dong-Hoon Chung
Recent studies have clearly underscored the association between Zika virus (ZIKV) and severe neurological diseases such as microcephaly and Guillain-Barre syndrome. Given the historical complacency surrounding this virus, however, no significant antiviral screenings have been performed to specifically target ZIKV. As a result, there is an urgent need for a validated screening method and strategy that is focused on highlighting potential anti-ZIKV inhibitors that can be further advanced via rigorous validation and optimization...
December 2, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27905123/selective-precipitation-reaction-a-novel-diagnostic-test-for-tissue-pathology-in-atlantic-salmon-salmo-salar-infected-with-salmonid-alphavirus-sav3
#6
M Braceland, J Tinsley, D Cockerill, R Bickerdike, M F McLoughlin, P D Eckersall
While investigating biomarkers for infection with salmonid alphavirus (SAV), the cause of pancreas disease (PD), a selective precipitation reaction (SPR) has been discovered in serum which could be an on-farm qualitative test and an in-laboratory quantitative assay for health assessments in aquaculture. Mixing serum from Atlantic salmon, Salmo salar, with SAV infection with a sodium acetate buffer caused a visible precipitation which does not occur with serum from healthy salmon. Proteomic examination of the precipitate has revealed that the components are a mix of muscle proteins, for example enolase and aldolase, along with serum protein such as serotransferrin and complement C9...
November 30, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/27902702/selective-inhibitor-of-nuclear-export-sine-compounds-alter-new-world-alphavirus-capsid-localization-and-reduce-viral-replication-in-mammalian-cells
#7
Lindsay Lundberg, Chelsea Pinkham, Cynthia de la Fuente, Ashwini Brahms, Nazly Shafagati, Kylie M Wagstaff, David A Jans, Sharon Tamir, Kylene Kehn-Hall
The capsid structural protein of the New World alphavirus, Venezuelan equine encephalitis virus (VEEV), interacts with the host nuclear transport proteins importin α/β1 and CRM1. Novel selective inhibitor of nuclear export (SINE) compounds, KPT-185, KPT-335 (verdinexor), and KPT-350, target the host's primary nuclear export protein, CRM1, in a manner similar to the archetypical inhibitor Leptomycin B. One major limitation of Leptomycin B is its irreversible binding to CRM1; which SINE compounds alleviate because they are slowly reversible...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27901124/analysis-of-chikungunya-virus-proteins-reveals-that-non-structural-proteins-nsp2-and-nsp3-exhibit-rna-interference-rnai-suppressor-activity
#8
Kalika Mathur, Abhishek Anand, Sunil Kumar Dubey, Neeti Sanan-Mishra, Raj K Bhatnagar, Sujatha Sunil
RNAi pathway is an antiviral defence mechanism employed by insects that result in degradation of viral RNA thereby curbing infection. Several viruses including flaviviruses encode viral suppressors of RNAi (VSRs) to counteract the antiviral RNAi pathway. Till date, no VSR has been reported in alphaviruses. The present study was undertaken to evaluate chikungunya virus (CHIKV) proteins for RNAi suppressor activity. We systematically analyzed all nine CHIKV proteins for RNAi suppressor activity using Sf21 RNAi sensor cell line based assay...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27899441/interferon-regulatory-factor-2-protects-mice-from-lethal-viral-neuroinvasion
#9
Melody M H Li, Leonia Bozzacco, Hans-Heinrich Hoffmann, Gaëlle Breton, Jakob Loschko, Jing W Xiao, Sébastien Monette, Charles M Rice, Margaret R MacDonald
The host responds to virus infection by activating type I interferon (IFN) signaling leading to expression of IFN-stimulated genes (ISGs). Dysregulation of the IFN response results in inflammatory diseases and chronic infections. In this study, we demonstrate that IFN regulatory factor 2 (IRF2), an ISG and a negative regulator of IFN signaling, influences alphavirus neuroinvasion and pathogenesis. A Sindbis virus strain that in wild-type (WT) mice only causes disease when injected into the brain leads to lethal encephalitis in Irf2(-/-) mice after peripheral inoculation...
November 29, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27890043/epidemic-host-community-contribution-to-mosquito-borne-disease-transmission-ross-river-virus
#10
I S Koolhof, S Carver
Most vector-borne diseases infect multiple host species, but disentangling the relative importance of different host species to transmission can be complex. Here we study how host species' abundance and competence (duration and titre of parasitaemia) influence host importance during epidemic scenarios. We evaluate this theory using Ross River virus (RRV, family Togaviridae, genus Alphavirus), a multi-host mosquito-borne disease with significant human health impacts across Australia and Papua New Guinea. We used host contribution models to find the importance of key hosts (possums, wallabies, kangaroos, horses, humans) in typical mammal communities around five Australian epidemic centres...
November 28, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27886209/virus-infection-drives-il-2-antibody-complexes-into-pro-inflammatory-agonists-in-mice
#11
Wendy W L Lee, Teck-Hui Teo, Fok-Moon Lum, Anand K Andiappan, Siti Naqiah Amrun, Laurent Rénia, Olaf Rötzschke, Lisa F P Ng
The use of IL-2/JES6-1 Ab complex (IL-2 Ab Cx) has been considered as a potential therapeutic for inflammatory diseases due to its selective expansion of regulatory T cells (Tregs) in mice. Here, IL-2 Ab Cx was explored as a therapeutic agent to reduce joint inflammation induced by chikungunya virus, an alphavirus causing debilitating joint disease globally. Virus-infected mice treated with IL-2 Ab Cx exhibited exacerbated joint inflammation due to infiltration of highly activated CD4(+) effector T cells (Teffs)...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870591/human-transcriptome-response-to-immunization-with-live-attenuated-venezuelan-equine-encephalitis-virus-vaccine-tc-83-analysis-of-whole-blood
#12
Rebecca A Erwin-Cohen, Aimee I Porter, Phillip R Pittman, Cynthia A Rossi, Luis DaSilva
Venezuelan equine encephalitis virus (VEEV) is an important human and animal alphavirus pathogen transmitted by mosquitoes. The virus is endemic in Central and South America, but has also caused equine outbreaks in southwestern areas of the United States. In an effort to better understand the molecular mechanisms of the development of immunity to this important pathogen, we performed transcriptional analysis from whole, unfractionated human blood of patients who had been immunized with the live-attenuated vaccine strain of VEEV, TC-83...
November 21, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27864552/immune-mediated-protection-and-pathogenesis-of-chikungunya-virus
#13
REVIEW
Julie M Fox, Michael S Diamond
Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized by production of type I IFNs, recruitment of innate and adaptive immune cells, and development of neutralizing Abs. Despite this response, chronic arthritis can develop in some individuals, which may be due to a failure to eliminate viral RNA and Ag and/or persistent immune responses that cause chronic joint inflammation. In this review, based primarily on advances from recent studies in mice, we discuss the innate and adaptive immune factors that control CHIKV dissemination and clearance or contribute to pathogenesis...
December 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27859355/ballan-wrasse-labrus-bergylta-ascanius-is-not-susceptible-to-pancreas-disease-caused-by-salmonid-alphavirus-subtype-2-and-3
#14
M V Røsaeg, H Sindre, D Persson, O Breck, D Knappskog, A B Olsen, T Taksdal
No abstract text is available yet for this article.
November 18, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/27856239/discovery-of-novel-multi-target-indole-based-derivatives-as-potent-and-selective-inhibitors-of-chikungunya-virus-replication
#15
Maria Scuotto, Rana Abdelnabi, Selene Collarile, Chiara Schiraldi, Leen Delang, Antonio Massa, Salvatore Ferla, Andrea Brancale, Pieter Leyssen, Johan Neyts, Rosanna Filosa
We recently identified indole derivatives (IIIe and IIIf) with anti-chikungunya virus (CHIKV) activities at lower micro molar concentrations and a selective index of inhibition higher than the lead compound Arbidol. Here we highlight new structural information for the optimization of the previously identified lead compounds that contain the indole chemical core. Based on the structural data, a series of indole derivatives was synthesized and tested for their antiviral activity against chikungunya virus in Vero cell culture by a CPE reduction assay...
October 31, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27852864/palmitoylation-of-sindbis-virus-tf-protein-regulates-its-plasma-membrane-localization-and-subsequent-incorporation-into-virions
#16
Jolene Ramsey, Emily C Renzi, Randy J Arnold, Jonathan C Trinidad, Suchetana Mukhopadhyay
: Palmitoylation is a reversible, post-translational modification that helps target proteins to cellular membranes. The alphavirus small membrane proteins 6K and TF have been reported to be palmitoylated and to positively regulate budding. 6K and TF are isoforms identical in the N-terminus but unique in the C-terminus due to a (-1) ribosomal frameshift during translation. In this study we used cysteine (Cys) mutants to test differential palmitoylation of Sindbis virus 6K and TF proteins...
November 16, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27852852/ablation-of-programmed-1-ribosomal-frameshifting-in-venezuelan-equine-encephalitis-virus-results-in-attenuated-neuropathogenicity
#17
Joseph A Kendra, Cynthia de la Fuente, Ashwini Brahms, Caitlin Woodson, Todd M Bell, Bin Chen, Yousuf A Khan, Jonathan L Jacobs, Kylene Kehn-Hall, Jonathan D Dinman
: The Alphaviruses, Venezuelan, eastern and western equine encephalitis viruses (VEEV, EEEV, WEEV) are arthropod-borne (+) RNA viruses that are capable of causing acute and fatal encephalitis in many mammals including humans. VEEV was weaponized during the Cold War, and is recognized as a select agent. Currently, there are no FDA approved vaccines or therapeutics for these viruses. The spread of VEEV and other members of this family due to climate change-mediated vector range expansion underscore the need for research aimed at developing medical countermeasures...
November 16, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27845418/chikungunya-virus-infectivity-rna-replication-and-non-structural-polyprotein-processing-depend-on-the-nsp2-protease-s-active-site-cysteine-residue
#18
Kai Rausalu, Age Utt, Tania Quirin, Finny S Varghese, Eva Žusinaite, Pratyush Kumar Das, Tero Ahola, Andres Merits
Chikungunya virus (CHIKV), genus Alphavirus, family Togaviridae, has a positive-stand RNA genome approximately 12 kb in length. In infected cells, the genome is translated into non-structural polyprotein P1234, an inactive precursor of the viral replicase, which is activated by cleavages carried out by the non-structural protease, nsP2. We have characterized CHIKV nsP2 using both cell-free and cell-based assays. First, we show that Cys478 residue in the active site of CHIKV nsP2 is indispensable for P1234 processing...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27827980/replicon-rna-viral-vectors-as-vaccines
#19
REVIEW
Kenneth Lundstrom
Single-stranded RNA viruses of both positive and negative polarity have been used as vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus and rhabdoviruses have been engineered for expression of surface protein genes and antigens. Administration of replicon RNA vectors has resulted in strong immune responses and generation of neutralizing antibodies in various animal models. Immunization of mice, chicken, pigs and primates with virus-like particles, naked RNA or layered DNA/RNA plasmids has provided protection against challenges with lethal doses of infectious agents and administered tumor cells...
November 7, 2016: Vaccines
https://www.readbyqxmd.com/read/27827562/complete-genome-sequencing-and-phylogenetic-analysis-of-a-getah-virus-strain-genus-alphavirus-family-togaviridae-isolated-from-culex-tritaeniorhynchus-mosquitoes-in-nagasaki-japan-in-2012
#20
Daisuke Kobayashi, Haruhiko Isawa, Hiroko Ejiri, Toshinori Sasaki, Toshihiko Sunahara, Kyoko Futami, Yoshio Tsuda, Yukie Katayama, Tetsuya Mizutani, Noboru Minakawa, Nobuo Ohta, Kyoko Sawabe
Getah virus (GETV; genus Alphavirus, family Togaviridae) is a mosquito-borne virus known to cause disease in horses and pigs. In 2014, for the first time in ∼30 years, a sudden GETV outbreak occurred among racehorses in Ibaraki, Japan. Two years before this outbreak, we obtained multiple GETV isolates from Culex tritaeniorhynchus mosquitoes collected in Nagasaki, Japan and determined the whole genome sequence of GETV isolate 12IH26. Our phylogenetic analysis of GETV strains revealed that the isolate 12IH26 forms a robust clade with the epidemic strains 14-I-605-C1 and 14-I-605-C2 isolated from horses in the 2014 outbreak in Ibaraki...
December 2016: Vector Borne and Zoonotic Diseases
keyword
keyword
38963
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"