Elizabeth E Zumbrun, Carly B Garvey, Jay B Wells, Ginger C Lynn, Sean Van Tongeren, Jesse T Steffens, Kelly S Wetzel, Laura M Gomba, Kristan A O'Brien, Franco D Rossi, Xiankun Zeng, Eric D Lee, Jo Lynne W Raymond, Diana A Hoffman, Alexandra N Jay, Elizabeth S Brown, Paul A Kallgren, Sarah L Norris, Jean Cantey-Kiser, Humza Kudiya, Chris Arthur, Christiana Blair, Darius Babusis, Victor C Chu, Bali Singh, Roy Bannister, Danielle P Porter, Tomas Cihlar, John M Dye
Marburg virus (MARV) causes severe disease and high mortality in humans. The objective of this study was to characterize disease manifestations and pathogenesis in cynomolgus macaques exposed to MARV. The results of this natural history study may be used to identify features of MARV disease useful in defining the ideal treatment initiation time for subsequent evaluations of investigational therapeutics using this model. Twelve cynomolgus macaques were exposed to a target dose of 1000 plaque-forming units MARV by the intramuscular route, and six control animals were mock-exposed...
November 28, 2023: Viruses