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https://www.readbyqxmd.com/read/29719780/establishment-of-pseudovirus-infection-mouse-models-for-in-vivo-pharmacodynamics-evaluation-of-filovirus-entry-inhibitors
#1
Qing Chen, Ke Tang, Xiaoyu Zhang, Panpan Chen, Ying Guo
Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which have restricted the development of anti-filovirus vaccines and drugs. An HIV-based pseudovirus cell infection assay is widely used for viral entry studies in BSL-2 conditions. Here, we successfully constructed nine in vitro pseudo-filovirus models covering all filovirus genera and three in vivo pseudo-filovirus-infection mouse models using Ebola virus, Marburg virus, and Lloviu virus as representative viruses...
March 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29706541/the-egyptian-rousette-genome-reveals-unexpected-features-of-bat-antiviral-immunity
#2
Stephanie S Pavlovich, Sean P Lovett, Galina Koroleva, Jonathan C Guito, Catherine E Arnold, Elyse R Nagle, Kirsten Kulcsar, Albert Lee, Françoise Thibaud-Nissen, Adam J Hume, Elke Mühlberger, Luke S Uebelhoer, Jonathan S Towner, Raul Rabadan, Mariano Sanchez-Lockhart, Thomas B Kepler, Gustavo Palacios
Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer cell receptors, MHC class I genes, and type I interferons, which dramatically differ from their functional counterparts in other mammals...
April 18, 2018: Cell
https://www.readbyqxmd.com/read/29689118/correction-a-prophylactic-multivalent-vaccine-against-different-filovirus-species-is-immunogenic-and-provides-protection-from-lethal-infections-with-ebolavirus-and-marburgvirus-species-in-non-human-primates
#3
Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn
[This corrects the article DOI: 10.1371/journal.pone.0192312.].
2018: PloS One
https://www.readbyqxmd.com/read/29688496/zmapptm-reinforces-the-airway-mucosal-barrier-against-ebola-virus
#4
Bing Yang, Alison Schaefer, Ying-Ying Wang, Justin McCallen, Phoebe Lee, Jay M Newby, Harendra Arora, Priya A Kumar, Larry Zeitlin, Kevin J Whaley, Scott A McKinley, William A Fischer, Dimple Harit, Samuel K Lai
Filoviruses, including Ebola, have the potential to be transmitted via virus-laden droplets deposited onto mucus membranes. Protecting against such emerging pathogens will require understanding how they may transmit at mucosal surfaces and developing strategies to reinforce the airway mucus barrier.Here, we prepared Ebola pseudovirus (with Zaire strain glycoproteins) and employed high resolution multiple particle tracking to track the motions of hundreds of individual pseudoviruses in fresh and undiluted human airway mucus isolated from extubated endotracheal tubes...
April 24, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29625392/the-current-landscape-of-nucleic-acid-tests-for-filovirus-detection
#5
REVIEW
David J Clark, John Tyson, Andrew D Sails, Sanjeev Krishna, Henry M Staines
Nucleic acid testing (NAT) for pathogenic filoviruses plays a key role in surveillance and to control the spread of infection. As they share clinical features with other pathogens, the initial spread of these viruses can be misdiagnosed. Tests that can identify a pathogen in the initial stages of infection are essential to control outbreaks. Since the Ebola virus disease (EVD) outbreak in 2014-2016 several tests have been developed that are faster than previous tests and more suited for field use. Furthermore, the ability to test for a range of pathogens simultaneously has been expanded to improve clinical pathway management of febrile syndromes...
March 22, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29601894/susceptibility-of-paramyxoviruses-and-filoviruses-to-inhibition-by-2-monofluoro-and-2-difluoro-4-azidocytidine-analogs
#6
Michael K Lo, Paul C Jordan, Sarah Stevens, Yuen Tam, Jerome Deval, Stuart T Nichol, Christina F Spiropoulou
Ebolaviruses, marburgviruses, and henipaviruses are zoonotic pathogens belonging to the Filoviridae and Paramyxoviridae families. They exemplify viruses that continue to spill over into the human population, causing outbreaks characterized by high mortality and significant clinical sequelae in survivors of infection. There are currently no approved small molecule therapeutics for use in humans against these viruses. In this study, we evaluated the antiviral activity of the nucleoside analog 4'-azidocytidine (4'N3 -C, R1479) and its 2'-monofluoro- and 2'-difluoro-modified analogs (2'F-4'N3 -C and 2'diF-4'N3 -C) against representative paramyxoviruses (Nipah virus, Hendra virus, measles virus, and human parainfluenza virus 3) and filoviruses (Ebola virus, Sudan virus, and Ravn virus)...
March 27, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29590293/considerations-for-randomised-controlled-trials-during-future-filovirus-outbreaks
#7
S T Jacob, R Colebunders
No abstract text is available yet for this article.
March 26, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29584652/identification-of-ellagic-acid-from-plant-rhodiola-rosea-l-as-an-anti-ebola-virus-entry-inhibitor
#8
Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A Davey, Han Cheng, Lijun Rong
The recent 2014-2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is available for the prevention and treatment. Traditional Chinese medicines (TCMs) represent a huge reservoir of bioactive chemicals and many TCMs have been shown to have antiviral activities. 373 extracts from 128 TCMs were evaluated using a high throughput assay to screen for inhibitors of Ebola virus cell entry...
March 27, 2018: Viruses
https://www.readbyqxmd.com/read/29551136/filoviruses-ecology-molecular-biology-and-evolution
#9
Jackson Emanuel, Andrea Marzi, Heinz Feldmann
The Filoviridae are a family of negative-strand RNA viruses that include several important human pathogens. Ebola virus (EBOV) and Marburg virus are well-known filoviruses which cause life-threatening viral hemorrhagic fever in human and nonhuman primates. In addition to severe pathogenesis, filoviruses also exhibit a propensity for human-to-human transmission by close contact, posing challenges to containment and crisis management. Past outbreaks, in particular the recent West African EBOV epidemic, have been responsible for thousands of deaths and vaulted the filoviruses into public consciousness...
2018: Advances in Virus Research
https://www.readbyqxmd.com/read/29511143/development-and-characterization-of-a-guinea-pig-model-for-marburg-virus
#10
Gary Wong, Wen-Guang Cao, Shi-Hua He, Zi-Rui Zhang, Wen-Jun Zhu, Estella Moffat, Hideki Ebihara, Carissa Embury-Hyatt, Xiang-Guo Qiu
The Angolan strain of Marburg virus (MARV/Ang) can cause lethal disease in humans with a case fatality rate of up to 90%, but infection of immunocompetent rodents do not result in any observable symptoms. Our previous work includes the development and characterization of a MARV/Ang variant that can cause lethal disease in mice (MARV/Ang-MA), with the aim of using this tool to screen for promising prophylactic and therapeutic candidates. An intermediate animal model is needed to confirm any findings from mice studies before testing in the gold-standard non-human primate (NHP) model...
January 18, 2018: Zoological Research
https://www.readbyqxmd.com/read/29511141/animal-models-for-filovirus-infections
#11
REVIEW
Vinayakumar Siragam, Gary Wong, Xiang-Guo Qiu
The family Filoviridae , which includes the genera Marburgvirus and Ebolavirus , contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research...
January 18, 2018: Zoological Research
https://www.readbyqxmd.com/read/29500195/design-and-evaluation-of-bi-and-trispecific-antibodies-targeting-multiple-filovirus-glycoproteins
#12
Elisabeth K Nyakatura, Samantha E Zak, Anna Z Wec, Daniel Hofmann, Sergey Shulenin, Russell R Bakken, M Javad Aman, Kartik Chandran, John M Dye, Jonathan R Lai
Filoviruses (family Filoviridae) include five ebolaviruses and Marburg virus. These pathogens cause a rapidly progressing and severe viral disease with high mortality rates (generally 30-90%). Outbreaks of filovirus disease are sporadic and, until recently, were limited to less than 500 cases. However, the 2013-2016 epidemic in western Africa, caused by Ebola virus (EBOV), illustrated the potential of filovirus outbreaks to escalate to a much larger scale (over 28,000 suspected cases). mAbs against the envelope glycoprotein represent a promising therapeutic platform for managing filovirus infections...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29498743/amiodarone-affects-ebola-virus-binding-and-entry-into-target-cells
#13
Cristiano Salata, Denis Munegato, Francesco Martelli, Cristina Parolin, Arianna Calistri, Aldo Baritussio, Giorgio Palù
Ebola Virus Disease is one of the most lethal transmissible infections characterized by a high fatality rate. Several research studies have aimed to identify effective antiviral agents. Amiodarone, a drug used for the treatment of arrhythmias, has been shown to inhibit filovirus infection in vitro by acting at the early step of the viral replication cycle. Here we demonstrate that amiodarone reduces virus binding to target cells and slows down the progression of the viral particles along the endocytic pathway...
March 2, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29494844/discovery-and-evolution-of-aloperine-derivatives-as-novel-anti-filovirus-agents-through-targeting-entry-stage
#14
Xin Zhang, Qiang Liu, Na Zhang, Qian-Qian Li, Zhan-Dong Liu, Ying-Hong Li, Li-Mei Gao, You-Chun Wang, Hong-Bin Deng, Dan-Qing Song
Preventing filoviruses in the entry stage is an attractive antiviral strategy. Taking aloperine, a Chinese natural herb with an endocyclic skeleton, as the lead, 23 new aloperine derivatives were synthesized and evaluated for their anti-filovirus activities including ebola virus (EBOV) and marburg virus (MARV) using pseudotyped virus model. Structure-activity relationship (SAR) analysis indicated that the introduction of a 12N-dichlorobenzyl group was beneficial for the potency. Compound 2e exhibited the most potent anti-EBOV and anti-MARV effects both in vitro and in vivo...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29486875/domesticated-animals-as-hosts-of-henipaviruses-and-filoviruses-a-systematic-review
#15
Emma E Glennon, Olivier Restif, Silke Riesle Sbarbaro, Romain Garnier, Andrew A Cunningham, Richard D Suu-Ire, Richard Osei-Amponsah, James L N Wood, Alison J Peel
Bat-borne viruses carry undeniable risks to the health of human beings and animals, and there is growing recognition of the need for a 'One Health' approach to understand their frequently complex spill-over routes. While domesticated animals can play central roles in major spill-over events of zoonotic bat-borne viruses, for example during the pig-amplified Malaysian Nipah virus outbreak of 1998-1999, the extent of their potential to act as bridging or amplifying species for these viruses has not been characterised systematically...
March 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29481881/use-of-the-filovirus-animal-non-clinical-group-fang-ebola-virus-immuno-assay-requires-fewer-study-participants-to-power-a-study-than-the-alpha-diagnostic-international-assay
#16
James Logue, Kaylie Tuznik, Dean Follmann, Greg Grandits, Jonathan Marchand, Cavan Reilly, Yeya Dit Sadio Sarro, James Pettitt, Eric J Stavale, Mosoka Fallah, Gene G Olinger, Fatorma K Bolay, Lisa E Hensley
As part of the scientific community's development of medical countermeasures against Ebola virus disease, optimization of standardized assays for product evaluation is paramount. The recent outbreak heightened awareness to the scarcity of available assays and limited information on performance and reproducibility. To evaluate the immunogenicity of vaccines entering Phase I-III trials and to identify survivors, two enzyme-linked immunosorbent assays, the Filovirus Animal Non-Clinical Group assay and the Alpha Diagnostics International assay, were evaluated for detection of immunoglobulin G against Ebola virus glycoprotein...
May 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29480365/-west-africa-ebola-outbreak-immediate-and-hands-on-formation-the-pre-deployment-training-program-for-frontline-aid-workers-of-the-german-red-cross-other-aid-organizations-and-the-german-armed-forces-wuerzburg-germany-2014-15
#17
REVIEW
Maximilian Gertler, Sven Loik, Christian Kleine, Alexa Matuschek, Norbert Gresser, Mario di Gennaro, Andreas Fabricius, Thomas Kratz, August Stich, Joost Butenop
BACKGROUND: In September 2014, the German government mandated the German Red Cross (GRC) and the German Armed Forces to support the international efforts to stop the epidemic of Ebola virus disease (EVD) in West-Africa. The GRC requested specific training from the Medical Mission Institute Wuerzburg (MI). OBJECTIVES: We describe and discuss the development, strategy, results, and evaluation of the program to formulate conclusions and recommendations for similar emergencies...
April 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29462200/a-prophylactic-multivalent-vaccine-against-different-filovirus-species-is-immunogenic-and-provides-protection-from-lethal-infections-with-ebolavirus-and-marburgvirus-species-in-non-human-primates
#18
Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn
The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections. A good prophylactic vaccine should be able to provide protection to all known filovirus species and as an upside potentially protect from newly emerging virus strains. We investigated the immunogenicity and protection elicited by multivalent vaccines expressing glycoproteins (GP) from Ebola virus (EBOV), Sudan virus (SUDV), Taï Forest virus (TAFV) and Marburg virus (MARV)...
2018: PloS One
https://www.readbyqxmd.com/read/29457711/small-animal-models-for-evaluating-filovirus-countermeasures
#19
Logan Banadyga, Gary Wong, Xiangguo Qiu
The development of novel therapeutics and vaccines to treat or prevent disease caused by filoviruses, such as Ebola and Marburg viruses, depends on the availability of animal models that faithfully recapitulate clinical hallmarks of disease as it is observed in humans. In particular, small animal models (such as mice and guinea pigs) are historically and frequently used for the primary evaluation of antiviral countermeasures, prior to testing in nonhuman primates, which represent the gold-standard filovirus animal model...
February 26, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29454637/tools-to-study-pathogen-host-interactions-in-bats
#20
REVIEW
Arinjay Banerjee, Vikram Misra, Tony Schountz, Michelle L Baker
Bats are natural reservoirs for a variety of emerging viruses that cause significant disease in humans and domestic animals yet rarely cause clinical disease in bats. The co-evolutionary history of bats with viruses has been hypothesized to have shaped the bat-virus relationship, allowing both to exist in equilibrium. Progress in understanding bat-virus interactions and the isolation of bat-borne viruses has been accelerated in recent years by the development of susceptible bat cell lines. Viral sequences similar to severe acute respiratory syndrome corona virus (SARS-CoV) have been detected in bats, and filoviruses such as Marburg virus have been isolated from bats, providing definitive evidence for the role of bats as the natural host reservoir...
March 15, 2018: Virus Research
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