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Lewy body dementia

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https://www.readbyqxmd.com/read/28928962/current-concepts-and-controversies-in-the-pathogenesis-of-parkinson-s-disease-dementia-and-dementia-with-lewy-bodies
#1
REVIEW
Rimona S Weil, Tammaryn L Lashley, Jose Bras, Anette E Schrag, Jonathan M Schott
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition. However, until recently, the pathophysiological mechanisms leading to neuronal damage were not known. It was also not understood why some cells are particularly vulnerable in PDD/DLB, nor why some individuals show more aggressive and rapid dementia than others...
2017: F1000Research
https://www.readbyqxmd.com/read/28926500/occipital-lobe-and-posterior-cingulate-perfusion-in-the-prediction-of-dementia-with-lewy-body-pathology-in-a-clinical-sample
#2
Angus M J Prosser, Livia Tossici-Bolt, Christopher M Kipps
OBJECTIVE: The aim of this study was to investigate the diagnostic value of occipital lobe and posterior cingulate perfusion in predicting dopamine transporter imaging outcome using a quantitative measure of analysis. PATIENTS AND METHODS: In total, 99 patients with cognitive complaints who had undergone both technetium-99m-hexamethylpropyleneamine oxime single-photon emission computed tomography (Tc-HMPAO SPECT) and I ioflupane (I-FP-CIT also called DaTSCAN) imaging in a dementia diagnostic center were analyzed...
September 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28922189/acr-acnm-practice-parameter-for-the-performance-of-dopamine-transporter-dat-single-photon-emission-computed-tomography-spect-imaging-for-movement-disorders
#3
Rathan M Subramaniam, Kirk A Frey, Christopher H Hunt, Gustavo A Mercier, Lilja B Solnes, Patrick M Colletti, Yang Lu, Bital Savir-Baruch, Hadyn T Williams
This American College of Radiology and American College of Nuclear Medicine joint clinical practice parameter is for performance of dopamine transporter single photon emission computed tomography (SPECT) imaging, for patients with movement disorders. Parkinsonian syndrome (PS) consists of a group of neurodegenerative diseases including Parkinson disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies (DLB). Accurate diagnosis of PS is critical for clinical management...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28919975/mild-cognitive-impairment-in-parkinson-s-disease-a-distinct-clinical-entity
#4
REVIEW
Ming-Ching Wen, Ling Ling Chan, Louis C S Tan, Eng King Tan
BACKGROUND: Mild cognitive impairment in Parkinson's disease (PD-MCI) is a common clinical condition. Understanding its pathology and clinical features is important for early intervention before the onset of dementia. In the past, variable definitions and differences in neuropsychological batteries generated divergent results of the affected cognitive patterns. MAIN BODY: The introduction of PD-MCI criteria by the Movement Disorders Society (MDS) Task Force provides a more uniform system for defining and measuring PD-MCI and may improve the validity of future research...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28913731/inter-and-intra-observer-reproducibility-of-quantitative-analysis-for-fp-cit-spect-in-patients-with-dlb
#5
Atsutaka Okizaki, Michihiro Nakayama, Kaori Nakajima, Takayuki Katayama, Takahiro Uno, Fumiyoshi Morikawa, Juichiro Naoe, Koji Takahashi
BACKGROUND: Dopamine transporter single photon emission CT (DAT-SPECT) is useful in the evaluation of dementia with Lewy bodies (DLB). The specific binding ratio (SBR) is an index to measure DAT density. However, poorly reproducible cases are occasionally experienced in clinical practice. We hypothesized that distance-weighted histogram (DWH) may be useful to improve the reproducibility of SBR. The purpose of this study was to investigate inter- and intra-observer reproducibility of SBR with conventional and DWH methods, and to visually evaluate the precision in reference voxel of interest (VOI) definition using these methods...
September 14, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28912672/maximizing-the-potential-of-longitudinal-cohorts-for-research-in-neurodegenerative-diseases-a-community-perspective
#6
Catherine J Moody, Derick Mitchell, Grace Kiser, Dag Aarsland, Daniela Berg, Carol Brayne, Alberto Costa, Mohammad A Ikram, Gail Mountain, Jonathan D Rohrer, Charlotte E Teunissen, Leonard H van den Berg, Joanna M Wardlaw
Despite a wealth of activity across the globe in the area of longitudinal population cohorts, surprisingly little information is available on the natural biomedical history of a number of age-related neurodegenerative diseases (ND), and the scope for intervention studies based on these cohorts is only just beginning to be explored. The Joint Programming Initiative on Neurodegenerative Disease Research (JPND) recently developed a novel funding mechanism to rapidly mobilize scientists to address these issues from a broad, international community perspective...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28911198/loss-of-native-%C3%AE-synuclein-multimerization-by-strategically-mutating-its-amphipathic-helix-causes-abnormal-vesicle-interactions-in-neuronal-cells
#7
Ulf Dettmer, Nagendran Ramalingam, Victoria E von Saucken, Tae-Eun Kim, Andrew J Newman, Elizabeth Terry-Kantor, Silke Nuber, Maria Ericsson, Saranna Fanning, Tim Bartels, Susan Lindquist, Oren A Levy, Dennis Selkoe
α-Synuclein (αS) forms round cytoplasmic inclusions in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Evidence suggests a physiological function of αS in vesicle trafficking and release. In contrast to earlier tenets, recent work indicates that αS normally exists in cells in a dynamic equilibrium between monomers and tetramers/multimers. We engineered αS mutants incapable of multimerization, leading to excess monomers at vesicle membranes. By EM, such mutants induced prominent vesicle clustering, leading to round cytoplasmic inclusions...
September 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28904388/protective-efficacy-of-phosphodiesterase-1-inhibition-against-alpha-synuclein-toxicity-revealed-by-compound-screening-in-luhmes-cells
#8
Matthias Höllerhage, Claudia Moebius, Johannes Melms, Wei-Hua Chiu, Joachim N Goebel, Tasnim Chakroun, Thomas Koeglsperger, Wolfgang H Oertel, Thomas W Rösler, Marc Bickle, Günter U Höglinger
α-synuclein-induced neurotoxicity is a core pathogenic event in neurodegenerative synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. There is currently no disease-modifying therapy available for these diseases. We screened 1,600 FDA-approved drugs for their efficacy to protect LUHMES cells from degeneration induced by wild-type α-synuclein and identified dipyridamole, a non-selective phosphodiesterase inhibitor, as top hit. Systematic analysis of other phosphodiesterase inhibitors identified a specific phosphodiesterase 1 inhibitor as most potent to rescue from α-synuclein toxicity...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899330/rem-sleep-behaviour-disorder-not-just-a-bad-dream
#9
REVIEW
Elie Matar, Simon Jg Lewis
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of the normal atonia during the REM stage of sleep, resulting in overt motor behaviours that usually represent the enactment of dreams. Patients will seek medical attention due to sleep-related injuries or unpleasant dream content. Idiopathic RBD which occurs independently of any other disease occurs in up to 2% of the older population. Meanwhile, secondary RBD is very common in association with certain neurodegenerative conditions...
September 18, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28892572/deconstructing-normal-pressure-hydrocephalus-ventriculomegaly-as-early-sign-of-neurodegeneration
#10
REVIEW
Alberto J Espay, Gustavo A Da Prat, Alok K Dwivedi, Federico Rodriguez-Porcel, Jennifer E Vaughan, Michela Rosso, Johnna L Devoto, Andrew P Duker, Mario Masellis, Charles D Smith, J George T Mandybur, Aristide Merola, Anthony E Lang
Idiopathic normal pressure hydrocephalus (NPH) remains both over-suspected on clinical grounds and under-confirmed when based on immediate and sustained response to cerebrospinal fluid diversion. Poor long-term post-shunt benefits and findings of neurodegenerative pathology in most patients with adequate follow up suggests that hydrocephalic disorders appearing in late adulthood may often result from initially unapparent parenchymal abnormalities. We critically review the NPH literature, highlighting the near universal lack of blinding and controls, the absence of specific clinical, imaging, or pathologic features, and the ongoing dependence for diagnostic confirmation on variable cutoffs of gait response to bedside fluid-drainage testing...
September 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28890381/the-link-between-parkinson-s-disease-and-rapid-eye-movement-sleep-behavior-disorder-with-dream-enactment-possible-implications-for-early-rehabilitation
#11
Brian P Johnson, Kelly P Westlake
The purpose of this paper is twofold. First, to inform readers of the link between the loss of motor inhibition during rapid eye movement (REM) sleep dreaming, diagnosed as REM sleep behavior disorder (RBD), and the future onset of neurodegenerative disorders, such as Parkinson's Disease and dementia with lewy bodies. It has been reported that motor disinhibition during rapid eye movement sleep often precedes onset of these disorders by years or even decades. Second, to consider that identification of RBD and the early involvement of rehabilitation and/or development of home exercise plans may aid in prolonging and even increasing function, independence, and quality of life should such neurodegenerative disorders develop later in life...
September 7, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28890165/reduction-of-the-anticholinergic-burden-makes-it-possible-to-decrease-behavioral-and-psychological-symptoms-of-dementia
#12
Yacine Jaïdi, Vignon Nonnonhou, Lukshe Kanagaratnam, Laurie Anne Bertholon, Sarah Badr, Vivien Noël, Jean-Luc Novella, Rachid Mahmoudi
OBJECTIVE: The aim of this study was to evaluate the impact of a reduction of the anticholinergic burden (AB) on the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) and their repercussions on the care team (occupational disruptiveness). METHODS: In this prospective, single-center study in an acute care unit for Alzheimer disease (AD) and related disorders, 125 elderly subjects (mean age: 84.4 years) with dementia presented with BPSD...
August 14, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28879902/review-of-tremor-in-parkinson-s-disease-and-atypical-parkinsonian-disorders
#13
Pooja Mailankody, M Netravathi, Pramod Kumar Pal
Rest tremor (RT), a cardinal feature of Parkinson's disease (PD) is often accompanied by other types of tremor such as action tremor, which includes postural tremor, kinetic tremor, re-emergent tremor (ReT), and orthostatic tremor (OT). Literature on other tremors of PD, especially ReT and OT, is scarce. Tremor can be present in any of the atypical parkinsonian disorders such as progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, and dementia with Lewy bodies. RT can even be the presenting symptom of these disorders...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28874525/differential-diagnosis-of-alzheimer-s-disease-using-spectrochemical-analysis-of-blood
#14
Maria Paraskevaidi, Camilo L M Morais, Kássio M G Lima, Julie S Snowden, Jennifer A Saxon, Anna M T Richardson, Matthew Jones, David M A Mann, David Allsop, Pierre L Martin-Hirsch, Francis L Martin
The progressive aging of the world's population makes a higher prevalence of neurodegenerative diseases inevitable. The necessity for an accurate, but at the same time, inexpensive and minimally invasive, diagnostic test is urgently required, not only to confirm the presence of the disease but also to discriminate between different types of dementia to provide the appropriate management and treatment. In this study, attenuated total reflection FTIR (ATR-FTIR) spectroscopy combined with chemometric techniques were used to analyze blood plasma samples from our cohort...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28872044/insular-cognitive-impairment-at-the-early-stage-of-dementia-with-lewy-bodies-a-preliminary-study
#15
Nathalie Philippi, Jennifer Kemp, Morgane Constans-Erbs, Malik Hamdaoui, Laetitia Monjoin, Emmanuelle Ehrhard, Timothée Albasser, Anne Botzung, Catherine Demuynck, Géraldine Heim, Catherine Martin-Hunyadi, Mathias Bilger, Laetitia Berly, David Soulier, Benjamin Cretin, Olivier Després, Frédéric Blanc
BACKGROUND: The anterior part of the insula appears atrophied in the early stage of dementia with Lewy bodies (DLB) whereas it is not the case in early Alzheimer's disease (AD). OBJECTIVE: The objective of this study was to develop neuropsychological markers supposed to reflect insular dysfunction, which would facilitate early diagnosis of DLB, namely in comparison to AD. METHODS: Twelve patients with DLB, 12 patients with AD, all at the stage of Mild cognitive impairment (MCI) or mild dementia, as well as 10 Controls subjects (CS) participated in the study...
September 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28871793/utility-of-montreal-cognitive-assessment-in-differentiating-dementia-with-lewy-bodies-from-alzheimer-s-dementia
#16
Erin Yamamoto, Lyla Mourany, Rosemary Colleran, Christine Whitman, Babak Tousi
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the 2 most common neurodegenerative dementias. Identification of patients with DLB is necessary to guide appropriate clinical management and medication trials. Patients with DLB are reported to perform poorly on tasks of visuospatial and executive function, compared to patients with AD who perform poorly on memory tasks. Using the Montreal Cognitive Assessment, we found that patients with DLB (n = 73) had statistically significant lower performance in clock drawing (visuospatial and executive function) and higher performance in delayed recall (memory) subscores compared to patients with AD (n = 57)...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28870518/multitep-platform-based-dna-vaccines-for-alpha-synucleinopathies-preclinical-evaluation-of-immunogenicity-and-therapeutic-potency
#17
Hayk Davtyan, Karen Zagorski, Irina Petrushina, Konstantin Kazarian, Natalie R S Goldberg, Janet Petrosyan, Mathew Blurton-Jones, Eliezer Masliah, David H Cribbs, Michael G Agadjanyan, Anahit Ghochikyan
We have previously demonstrated that anti-beta amyloid DNA vaccine (AV-1959D) based on our proprietary MultiTEP platform technology is extremely immunogenic in mice, rabbits, and monkeys. Importantly, MultiTEP platform enables development of vaccines targeting pathological molecules involved in various neurodegenerative disorders. Taking advantage of the universality of MultiTEP platform, we developed DNA vaccines targeting 3 B-cell epitopes (amino acids [aa]85-99, aa109-126, and aa126-140) of human alpha-synuclein (hα-Syn) separately or all 3 epitopes simultaneously...
August 10, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28856994/lack-of-research-about-dementia-with-lewy-bodies
#18
(no author information available yet)
Dementia with Lewy bodies, which is characterised by clumps of protein that develop inside nerve cells in the brain, accounts for 10%-20% of dementia cases. Cognitive symptoms start with visuospatial and executive functions rather than with memory. Psychiatric and behavioural features, especially hallucinations, sleep disturbances and apathy, are common and often present early in the course of the disease.
August 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28843020/clinicopathologic-discrepancies-in-a-population-based-incidence-study-of-parkinsonism-in-olmsted-county-1991-2010
#19
Pierpaolo Turcano, Michelle M Mielke, Keith A Josephs, James H Bower, Joseph E Parisi, Bradley F Boeve, Rodolfo Savica
OBJECTIVE: The purpose of this study was to examine the discrepancies between the clinical diagnosis of parkinsonism and neuropathological findings in a population-based cohort with parkinsonian disorders. BACKGROUND: The specific clinical diagnosis of parkinsonism is challenging, and definite confirmation requires neuropathological evaluation. Currently, autopsies are seldom performed, and most brain autopsies represent atypical or diagnostically unresolved cases...
August 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28842567/insular-atrophy-at-the-prodromal-stage-of-dementia-with-lewy-bodies-a-vbm-dartel-study
#20
Daniel Roquet, Vincent Noblet, Pierre Anthony, Nathalie Philippi, Catherine Demuynck, Benjamin Cretin, Catherine Martin-Hunyadi, Paulo Loureiro de Sousa, Frédéric Blanc
Diffuse atrophy including the insula was previously demonstrated in dementia with Lewy bodies (DLB) patients but little is known about the prodromal stage of DLB (pro-DLB). In this prospective study, we used SPM8-DARTEL to measure gray matter (GM) and white matter (WM) atrophy in pro-DLB patients (n = 54), prodromal Alzheimer's disease (pro-AD) patients (n = 16), DLB patients at the stage of dementia (mild-DLB) (n = 15), and Alzheimer's disease patients at the stage of dementia (mild-AD) (n = 28), and compared them with healthy elderly controls (HC, n = 22)...
August 25, 2017: Scientific Reports
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