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Lewy body dementia

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https://www.readbyqxmd.com/read/29133699/referral-practice-reporting-standards-and-the-impact-of-dopamine-transporter-scans-done-in-a-tertiary-hospital
#1
Shakya Bhattacharjee, Albi J Chalissery, Tim Barry, Donagh O'Sullivan, Martin O'Connell, Timothy Lynch
AIMS: We studied the referral practice, reporting standards, and the impact of 123 ioflupane single photon emission computed tomogram dopamine transporters (DAT-SPECT) scans conducted for the diagnosis and clinical management of patients. SETTINGS AND DESIGNS: The present study was a retrospective, non-interventional study. MATERIALS AND METHODS: We assessed the DAT scan referral and the official reports available from the Nuclear Medicine Department of the Mater Misericordiae University Hospital over 1 year (2013)...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29131019/utility-of-autonomic-function-tests-to-differentiate-dementia-with-lewy-bodies-and-parkinson-disease-with-dementia-from-alzheimer-disease
#2
Shuta Toru, Tadashi Kanouchi, Takanori Yokota, Yosuke Yagi, Akira Machida, Takayoshi Kobayashi
OBJECTIVE: We studied autonomic disturbance in patients with dementia with Lewy bodies (DLB), Parkinson disease with dementia (PDD), Alzheimer disease (AD), to determine whether autonomic function tests can be used to distinguish these disorders. METHODS: Autonomic function was tested in 56 patients with DLB, 37 patients with PDD, and 59 patients with AD by using the sympathetic skin response, coefficient of variation in R-R interval, the head-up tilt test, serum norepinephrine concentration, and 123I-meta-iodobenzylguanidine cardiac scintigraphy...
November 13, 2017: European Neurology
https://www.readbyqxmd.com/read/29126445/ykl-40-in-the-brain-and-cerebrospinal-fluid-of-neurodegenerative-dementias
#3
Franc Llorens, Katrin Thüne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andréoletti, Natalia Fernández-Borges, Ina M Vorberg, Markus Glatzel, Theodoros Sklaviadis, Juan Maria Torres, Susanne Krasemann, Raquel Sánchez-Valle, Isidro Ferrer, Inga Zerr
BACKGROUND: YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. METHODS: In the present study, we comparatively analysed YKL-40 levels in the brain and CSF samples from neurodegenerative dementias of different aetiologies characterized by the presence of cortical pathology and disease-specific neuroinflammatory signatures...
November 10, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29119326/neurodegeneration-and-the-ordered-assembly-of-%C3%AE-synuclein
#4
REVIEW
Maria Grazia Spillantini, Michel Goedert
In 2017, it was 200 years since James Parkinson published 'An Essay on the Shaking Palsy' and 20 years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson's disease and dementia with Lewy bodies as the third major synucleinopathy. Here, we describe the work that led to the identification of α-synuclein in Lewy bodies, Lewy neurites and Papp-Lantos bodies. We also review some of the findings reported since 1997.
November 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29117955/alzheimer-s-disease-related-dementias-summit-2016-national-research-priorities
#5
REVIEW
Roderick A Corriveau, Walter J Koroshetz, Jordan T Gladman, Sophia Jeon, Debra Babcock, David A Bennett, S Thomas Carmichael, Susan L-J Dickinson, Dennis W Dickson, Marian Emr, Howard Fillit, Steven M Greenberg, Michael L Hutton, David S Knopman, Jennifer J Manly, Karen S Marder, Claudia S Moy, Creighton H Phelps, Paul A Scott, William W Seeley, Beth-Anne Sieber, Nina B Silverberg, Margaret L Sutherland, Angela Taylor, Christine L Torborg, Salina P Waddy, Amelie K Gubitz, David M Holtzman
Goal 1 of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by 2025. To help inform the research agenda toward achieving this goal, the NIH hosts periodic summits that set and refine relevant research priorities for the subsequent 5 to 10 years. This proceedings article summarizes the 2016 Alzheimer's Disease-Related Dementias Summit, including discussion of scientific progress, challenges, and opportunities in major areas of dementia research, including mixed-etiology dementias, Lewy body dementia, frontotemporal degeneration, vascular contributions to cognitive impairment and dementia, dementia disparities, and dementia nomenclature...
November 8, 2017: Neurology
https://www.readbyqxmd.com/read/29116402/a-critical-review-of-the-prion-hypothesis-of-human-synucleinopathies
#6
REVIEW
Gültekin Tamgüney, Amos D Korczyn
Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are neurodegenerative disorders which have been pathologically classified as synucleinopathies, since they are associated with pathognomonic deposits of misfolded alpha-synuclein in cells of the nervous system. Recently PD, DLB, and MSA were also suggested to be prion-like disorders. Much controversy exists regarding this analogy between synucleinopathies and prion diseases. Here, we discuss what characterizes prion diseases and in which way synucleinopathies may be considered prion-like or -unlike...
November 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29116145/cingulate-island-sign-temporally-changes-in-dementia-with-lewy-bodies
#7
Tomomichi Iizuka, Rui Iizuka, Masashi Kameyama
The cingulate island sign (CIS) that reflects sparing of the posterior cingulate cortex (PCC) relative to the precuneus plus cuneus on FDG-PET and brain perfusion SPECT, has been proposed as a feature of dementia with Lewy bodies (DLB). As the CIS is influenced by concomitant Alzheimer's disease (AD)-type neurofibrillary tangle (NFT) pathology, we postulated that the CIS gradually disappears as DLB progresses. To determine temporal changes in the CIS, 24 patients with mild DLB and 7 with prodromal DLB underwent (123)I-IMP-SPECT and MMSE twice at an interval of two years...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29112909/potential-diagnostic-value-of-131-i-mibg-myocardial-scintigraphy-in-discrimination-between-alzheimer-disease-and-dementia-with-lewy-bodies
#8
Mehrshad Abbasi, Nafise Ghalandari, Saeed Farzanefar, Vajiheh Aghamollaii, Mona Ahmadi, Morsaleh Ganji, Mohsen Afarideh, Sogol Loloee, Maryam Naseri, Abbas Tafakhori
OBJECTIVES: Clinical difficulty to discriminate between the Alzheimer disease (AD) and dementia with Lewy bodies (DLB) has led researchers to focus on highly sensitive functional imaging modalities. The aim of the present study was to assess (131)I-MIBG cardiac imaging to distinguish between AD and DLB. PATIENTS AND METHODS: Seventeen patients who were known cases of dementia underwent (131)I-MIBG myocardial scintigraphy to differentiate AD from DLB. Planar and (131)I-MIBG SPECT were obtained 2h after the injection of 1mCi (131)I-MIBG on a dual head gamma camera...
October 25, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29111367/synthesis-and-biological-evaluation-of-novel-radioiodinated-benzimidazole-derivatives-for-imaging-%C3%AE-synuclein-aggregates
#9
Hiroyuki Watanabe, Taisuke Ariyoshi, Akihiko Ozaki, Masafumi Ihara, Masahiro Ono, Hideo Saji
α-Synuclein (α-syn) aggregates are commonly found in the brains of patients with Parkinson's disease (PD), dementia with Lewy bodies (DLB), and some other diseases. Therefore, in vivo imaging of α-syn aggregates would aid in drug development, early diagnosis, and monitoring of disease status. In order to develop imaging probes targeting α-syn aggregates, we synthesized and evaluated three novel radioiodinated benzimidazole (BI) derivatives for selective imaging of α-syn aggregates. In binding experiments, BI-2 exhibited the highest selective binding affinity for α-syn aggregates among the BI derivatives...
October 14, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29110781/cerebrospinal-fluid-in-the-dementias
#10
Henrik Zetterberg, Jonathan D Rohrer, Jonathan M Schott
Alzheimer disease, vascular dementia, dementia with Lewy bodies, and frontotemporal dementia are the most common central nervous system disorders that cause progressive neurocognitive dysfunction and ultimately dementia. A number of biomarkers for pathologies reflecting each condition have been developed. Here, we review these and give an overview of the current state of practice and research regarding cerebrospinal fluid biomarkers for these disorders. The chapter discusses both established (most of which are tau- and amyloid β-related) and upcoming biomarkers and details, wherever appropriate, clinical use and differential diagnostics aspects...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29103031/transcranial-sonography-in%C3%A2-neurodegenerative-diseases-with-cognitive-decline
#11
Silvia Favaretto, Uwe Walter, Claudio Baracchini, Annachiara Cagnin
Transcranial sonography (TCS) of the brain parenchyma detects alterations in the substantia nigra (SN), raphe nuclei, and basal ganglia; this technique has been established as a tool for the early diagnosis of Parkinson's disease and differential diagnosis from atypical parkinsonian syndromes. Here, we aimed to review the main applications of TCS in neurodegenerative diseases presenting with dementia syndrome, focusing on Alzheimer's disease (AD), dementia with Lewy bodies (DLB), frontotemporal lobar degeneration, idiopathic normal pressure hydrocephalus, and atypical and secondary parkinsonisms...
November 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29101940/rem-sleep-behavior-disorder-diagnosis-clinical-implications-and-future-directions
#12
REVIEW
Erik K St Louis, Bradley F Boeve
Rapid eye movement sleep behavior disorder (RBD) is diagnosed by a clinical history of dream enactment accompanied by polysomnographic rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia). Rapid eye movement sleep behavior disorder is strongly associated with neurodegenerative disease, especially synucleinopathies such as Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. A history of RBD may begin several years to decades before onset of any clear daytime symptoms of motor, cognitive, or autonomic impairments, suggesting that RBD is the presenting manifestation of a neurodegenerative process...
November 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29101136/mortality-in-dementia-with-lewy-bodies-compared-with-alzheimer-s-dementia-a-retrospective-naturalistic-cohort-study
#13
Annabel Price, Redwan Farooq, Jin-Min Yuan, Vandana B Menon, Rudolf N Cardinal, John T O'Brien
OBJECTIVES: To use routine clinical data to investigate survival in dementia with Lewy bodies (DLB) compared with Alzheimer's dementia (AD). DLB is the second most common dementia subtype after AD, accounting for around 7% of dementia diagnoses in secondary care, though studies suggest that it is underdiagnosed by up to 50%. Most previous studies of DLB have been based on select research cohorts, so little is known about the outcome of the disease in routine healthcare settings. SETTING: Cambridgeshire & Peterborough NHS Foundation Trust, a mental health trust providing secondary mental health care in England...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29100980/the-limbic-and-neocortical-contribution-of-%C3%AE-synuclein-tau-and-%C3%AE-amyloid-to-disease-duration-in-dementia-with-lewy-bodies
#14
Tanis J Ferman, Naoya Aoki, Julia E Crook, Melissa E Murray, Neill R Graff-Radford, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Jonathan Graff-Radford, Otto Pedraza, Kejal Kantarci, Bradley F Boeve, Dennis W Dickson
INTRODUCTION: We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and β-amyloid to duration of illness in dementia with Lewy bodies (DLB). METHODS: Quantitative digital pathology of neocortical and limbic α-synuclein, tau, and β-amyloid was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration...
October 31, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29096630/trajectories-of-physical-function-prior-to-death-and-brain-neuropathology-in-a-community-based-cohort-the-act-study
#15
Andrea Z LaCroix, Rebecca A Hubbard, Shelly L Gray, Melissa L Anderson, Paul K Crane, Joshua A Sonnen, Oleg Zaslavsky, Eric B Larson
BACKGROUND: Mechanisms linking cognitive and physical functioning in older adults are unclear. We sought to determine whether brain pathological changes relate to the level or rate of physical performance decline. METHODS: This study analyzed data from 305 participants in the autopsy subcohort of the prospective Adult Changes in Thought (ACT) study. Participants were aged 65+ and free of dementia at enrollment. Physical performance was measured at baseline and every two years using the Short Physical Performance Battery (SPPB)...
November 2, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29094778/long-reaction-times-are-associated-with-delayed-brain-activity-in-lewy-body-dementia
#16
Michael J Firbank, John T O'Brien, John Paul Taylor
A significant symptom of Lewy body dementia (LBD) is slow cognitive processing or bradyphrenia. In a previous fMRI task-based study, we found slower responses in LBD, accompanied by greater deactivation in the default mode network. In this study, we investigated the timing and magnitude of the activations and deactivations with respect to reaction time to determine whether the slower responses in LBD were associated with delayed neuronal activity. Using fMRI, we examined the magnitude and latency of activations and deactivations during an event-related attention task in 32 patients with LBD and 23 healthy controls using predefined regions of interest...
November 2, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29092095/a%C3%AE-exacerbates-%C3%AE-synuclein-induced-neurotoxicity-through-impaired-insulin-signaling-in-%C3%AE-synuclein-overexpressed-human-sk-n-mc-neuronal-cells
#17
Ching-Chi Chang, Hsin-Hua Li, Yen-Ting Chang, Ying-Jui Ho, Ling-Jia Hsieh, Pai-Yi Chiu, Yu-Shih Cheng, Chih-Li Lin, Te-Jen Lai
AIM: α-Synuclein (αSyn) is known as a small soluble protein abundantly expressed in neuronal cells. Although its physiological role is still unclear, the aggregation of αSyn has been recognized as responsible for some neurodegenerative disorders such as dementia with Lewy bodies (DLB). In most cases, intracellular abnormal aggregates are caused by protein-coding mutations that alter primary structure and therefore increase propensity toward aggregation. However, no pathogenic alterations or polymorphisms in αSyn are found in DLB patients so far, suggesting genetic mutations may not play a major role in DLB pathogenesis...
November 1, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29078129/age-and-the-association-of-dementia-related-pathology-with-trajectories-of-cognitive-decline
#18
Willemijn J Jansen, Robert S Wilson, Pieter Jelle Visser, Sukriti Nag, Julie A Schneider, Bryan D James, Sue E Leurgans, Ana W Capuano, David A Bennett, Patricia A Boyle
The association of dementia-related pathologies with cognition is hypothesized to decrease as age advances. We examined this in 413 persons without cognitive impairment at baseline who completed annual cognitive evaluations during a mean of 10.4 years. After death, neuropathologic examinations quantified beta amyloid plaque load, neurofibrillary tangles, and transactive response DNA-binding protein 43 pathology, and identified Lewy bodies, hippocampal sclerosis, and gross and microscopic cerebral infarcts...
September 5, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29077801/introduction-to-the-special-issue-on-clinical-neuropsychology-of-movement-disorders
#19
Alexander I Tröster
The special issue on the clinical neuropsychology of movement disorders provides an overview for the non-subspecialist clinical neuropsychologist and other clinical neuroscientists of the neuropsychological features, assessment and treatment of Parkinson's disease and Lewy body dementias, atypical parkinsonian disorders (corticobasal syndrome, progressive supranuclear palsy, and multiple system atrophy), Huntington's disease, dystonia, and amyotrophic lateral sclerosis. Additionally, articles provide overviews of neuropsychological and ethical issues related to deep brain stimulation and a discussion of non-pharamcologic and non-invasive treatment of cognitive dysfunction in Parkinson's disease...
November 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29067344/determining-the-impact-of-psychosis-on-rates-of-false-positive-and-false-negative-diagnosis-in-alzheimer-s-disease
#20
Corinne E Fischer, Winnie Qian, Tom A Schweizer, Zahinoor Ismail, Eric E Smith, Colleen P Millikin, David G Munoz
INTRODUCTION: The rate of clinical misdiagnosis of Alzheimer's disease (AD) and how psychosis impacts that clinical judgment is unclear. METHODS: Using data from National Alzheimer's Coordinating Center, we compared the clinical and neuropathologic diagnosis in patients with a diagnosis of AD with autopsy and in neuropathology-confirmed AD cases (n = 961). We determined the rate of true positives, false positives, and false negatives in patients with and without psychosis...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
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