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Artificial endocrine pancreas

Clara V Alvarez, Fernando Oroz-Gonjar, Montserrat Garcia-Lavandeira
No abstract text is available yet for this article.
April 15, 2017: Molecular and Cellular Endocrinology
Naoji Mita, Shinji Kawahito, Tomohiro Soga, Kazumi Takaishi, Hiroshi Kitahata, Munehide Matsuhisa, Mitsuo Shimada, Hiroyuki Kinoshita, Yasuo M Tsutsumi, Katsuya Tanaka
The aim of the present study was to evaluate the usefulness of a closed-loop system (STG-55; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose, for preventing postoperative acute kidney injury (AKI) in patients undergoing hepatectomy. Thirty-eight patients were enrolled in this study. Glucose concentrations were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n = 19) or the programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n = 19)...
March 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Peter G Jacobs, Navid Resalat, Joseph El Youssef, Ravi Reddy, Deborah Branigan, Nicholas Preiser, John Condon, Jessica Castle
In this article, we present several important contributions necessary for enabling an artificial endocrine pancreas (AP) system to better respond to exercise events. First, we show how exercise can be automatically detected using body-worn accelerometer and heart rate sensors. During a 22 hour overnight inpatient study, 13 subjects with type 1 diabetes wearing a Zephyr accelerometer and heart rate monitor underwent 45 minutes of mild aerobic treadmill exercise while controlling their glucose levels using sensor-augmented pump therapy...
October 5, 2015: Journal of Diabetes Science and Technology
Nadiah Ghazalli, Alborz Mahdavi, Tao Feng, Liang Jin, Mark T Kozlowski, Jasper Hsu, Arthur D Riggs, David A Tirrell, H Teresa Ku
Postnatal pancreas is a potential source for progenitor cells to generate endocrine β-cells for treating type 1 diabetes. However, it remains unclear whether young (1-week-old) pancreas harbors multipotent progenitors capable of differentiating into duct, acinar, and endocrine cells. Laminin is an extracellular matrix (ECM) protein important for β-cells' survival and function. We established an artificial extracellular matrix (aECM) protein that contains the functional IKVAV (Ile-Lys-Val-Ala-Val) sequence derived from laminin (designated aECM-lam)...
September 1, 2015: Stem Cells and Development
Noriko Kambe, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Toshiko Katayama, Yoko Sakai, Tomohiro Soga, Hiroaki Kawano, Munehide Matsuhisa, Mitsuo Shimada, Tetsuya Kitagawa, Hiroshi Kitahata
BACKGROUND: Recent studies have shown that strict perioperative blood glucose management may reduce mortality and morbidity in critically ill adult patients. The purpose of this study was to assess the accuracy and efficacy of the intraoperative application of a newly developed, next-generation artificial endocrine pancreas (STG-55, Nikkiso Co., Ltd., Tokyo, Japan). METHODS: Twenty patients scheduled to undergo surgery were enrolled in this study. The STG-55 is designed to be more user-friendly than its conventional counterpart (STG-22) while maintaining the latter's fundamental functions, such as a closed-loop system using algorithms for insulin and glucose infusion...
2015: Journal of Medical Investigation: JMI
Matilde Otero-Losada, Gabriel Cao, Julián González, Angélica Muller, Graciela Ottaviano, Christopher Lillig, Francisco Capani, Giuseppe Ambrosio, José Milei
AIM: We report the effects of long-term cola beverage drinking on glucose homeostasis, endocrine pancreas function and morphology in rats. METHODS: Wistar rats drank: water (group W), regular cola beverage (group C, sucrose sweetened) or "light" cola beverage (group L, artificially sweetened). After 6 months, 50% of the animals in each group were euthanized and the remaining animals consumed water for the next 6 months when euthanasia was performed. Biochemical assays, insulinemia determination, estimation of insulin resistance (HOMA-IR), morphometry and immunohistochemistry evaluations were performed in pancreas...
2015: PloS One
Chao Fang, Bo Ning, Ahmed Bilal Waqar, Manabu Niimi, Shen Li, Kaneo Satoh, Masashi Shiomi, Ting Ye, Sijun Dong, Jianglin Fan
Bisphenol A (BPA) is an artificial environmental endocrine disrupter. Excess exposure to BPA may induce many disorders in the metabolism and cardiovascular system. However, the underlying toxicological mechanisms remain largely unknown. In this study, we administered genetically hyperlipidemic Watanabe heritable hyperlipidemic (WHHL-MI) rabbits (male, 14 week old), which have more common features with humans than the mouse and rat especially in the metabolism and cardiovascular system, with BPA at 40 mg kg(-1)  day(-1) for 8 weeks by gavage and compared their plasma lipids, glucose and insulin response with those of the vehicle group...
September 2015: Journal of Applied Toxicology: JAT
Kayo Hirose, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Tomiya Kawahara, Tomohiro Soga, Toshiko Katayama, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mitsuo Shimada, Munehide Matsuhisa, Hiroshi Kitahata
A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level was controlled using the artificial endocrine pancreas, which enabled continuous blood glucose monitoring and computer-operated glucose and insulin infusion to maintain the blood glucose level at a steady state...
2014: Journal of Medical Investigation: JMI
Ling Hinshaw, Michele Schiavon, Ashwini Mallad, Chiara Dalla Man, Rita Basu, Adil E Bharucha, Claudio Cobelli, Rickey E Carter, Ananda Basu, Yogish C Kudva
Controlling meal-related glucose excursions continues to be a therapeutic challenge in diabetes mellitus. Mechanistic reasons for this need to be understood better to develop appropriate therapies. To investigate delayed gastric emptying effects on postprandial glucose turnover, insulin sensitivity, and β-cell responsivity and function, as a feasibility study prior to studying patients with type 1 diabetes, we used the triple tracer technique C-peptide and oral minimal model approach in healthy subjects. A single dose of 30 μg of pramlintide administered at the start of a mixed meal was used to delay gastric emptying rates...
September 15, 2014: American Journal of Physiology. Endocrinology and Metabolism
Nicholas Caputo, Melanie A Jackson, Jessica R Castle, Joseph El Youssef, Parkash A Bakhtiani, Colin P Bergstrom, Julie M Carroll, Matthew E Breen, Gerald L Leonard, Larry L David, Charles T Roberts, W Kenneth Ward
BACKGROUND: For patients with type 1 diabetes mellitus, a bihormonal artificial endocrine pancreas system utilizing glucagon and insulin has been found to stabilize glycemic control. However, commercially available formulations of glucagon cannot currently be used in such systems because of physical instability characterized by aggregation and chemical degradation. Storing glucagon at pH 10 blocks protein aggregation but results in chemical degradation. Reductions in pH minimize chemical degradation, but even small reductions increase protein aggregation...
November 2014: Diabetes Technology & Therapeutics
Kazuhiro Hanazaki, Hiroyuki Kitagawa, Tomoaki Yatabe, Masaya Munekage, Ken Dabanaka, Yuka Takezaki, Yuuki Tsukamoto, Takuji Asano, Yoshihiko Kinoshita, Tsutomu Namikawa
BACKGROUND: We examined whether perioperative intensive insulin therapy (IIT) using an artificial pancreas (AP) with a closed-loop glycemic control system can be used to prevent hypoglycemia in surgical patients. METHODS: Between 2006 and 2012, perioperative glycemic control using an AP was performed in 427 patients undergoing general surgery. A total of 305 patients undergoing IIT using an AP in the target blood glucose range of 80 to 110 mg/dL were enrolled in the study...
June 2014: American Journal of Surgery
Tsuyoshi Okada, Shinji Kawahito, Naoji Mita, Munehide Matsuhisa, Hiroshi Kitahata, Mitsuo Shimada, Shuzo Oshita
BACKGROUND: The purpose of this study was to evaluate the usefulness of the closed-loop system (STG-22; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose in patients undergoing liver transplantation. METHODS: Sixteen patients undergoing living-donor liver transplantation were enrolled in this study. Glucose levels were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n=8) or a programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n=8)...
2013: Journal of Medical Investigation: JMI
Y H Jo, B M Nam, B Y Kim, J G Nemeno, S Lee, J E Yeo, W Yang, S H Park, Y S Kim, J I Lee
Investigators conducting diabetes-related research have focused on islet transplantation as a radical therapy for type 1 diabetes mellitus. Pancreatic islet isolation, an essential process, is a very demanding work because of the proteolytic enzymes, species, treatment time, and individual difference. Replacement of primary isolated pancreatic islets must be carried out continuously for various in vitro tests, making primary isolated islets a useful tool for cell transplantation research. Hence, we sought to develop pseudoislets from commercial pancreas-derived cell lines...
October 2013: Transplantation Proceedings
Kazuhiro Hanazaki, Tsutomu Namikawa
It is well known that tight glycemic control (TGC) in patients with diabetes mellitus is the most important to reduce complications, such as nephropathy, neuropathy, and retinopathy. Also, surgical stress induced hyperglycemia leading to glucose toxicity is the main cause of infectious complications after surgery. Recently perioperative TGC has been proven an effective method to reduce postoperative infectious complications and accelerate enhanced recovery after surgery (ERAS), with the main purpose of short staying hospital...
2013: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Shinji Kawahito, Seiichi Higuchi, Naoji Mita, Tetsuya Kitagawa, Hiroshi Kitahata
We tried to perform continuous blood glucose monitoring during cardiovascular surgery involving cardiopulmonary bypass using an artificial endocrine pancreas (STG-22 or -55; Nikkiso, Tokyo, Japan); however, we often encountered problems during these procedures because insufficient blood was obtained for monitoring. Thus, we started performing the blood sampling via the venous side of the cardiopulmonary bypass circuit. As a result, continuous blood glucose monitoring using an artificial endocrine pancreas was proven to be stable and reliable during cardiovascular surgery involving cardiopulmonary bypass...
December 2013: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Chinmay Manohar, Derek T O'Keeffe, Ling Hinshaw, Ravi Lingineni, Shelly K McCrady-Spitzer, James A Levine, Rickey E Carter, Ananda Basu, Yogish C Kudva
BACKGROUND: Currently, patients with type 1 diabetes decide on the amount of insulin to administer based on several factors, including current plasma glucose value, expected meal input, and physical activity (PA). One future therapeutic modality for patients with type 1 diabetes is the artificial endocrine pancreas (AEP). Incorporation of PA could enhance the efficacy of AEP significantly. We compared the main technologies used for PA quantitation. SUBJECTS AND METHODS: Data were collected during inpatient studies involving healthy control subjects and type 1 diabetes...
September 2013: Diabetes Technology & Therapeutics
Peter E Picton, Melanie Yeung, Nathaniel Hamming, Lane Desborough, Eyal Dassau, Joseph A Cafazzo
Despite advancements in the development of the artificial pancreas, barriers in the form of proprietary data and communication protocols of diabetes devices have made the integration of these components challenging. The Artificial Pancreas Standards and Technical Platform Project is an initiative funded by the JDRF Canadian Clinical Trial Network with the goal of developing device communication standards for the interoperability of diabetes devices. Stakeholders from academia, industry, regulatory agencies, and medical and patient communities have been engaged in advancing this effort...
July 1, 2013: Journal of Diabetes Science and Technology
Evanthia Pashos, Joon Tae Park, Steven Leach, Shannon Fisher
Development of the pancreas and cerebellum require Pancreas-specific transcription factor-1a (Ptf1a), which encodes a subunit of the transcription factor complex PTF1. Ptf1a is required in succession for specification of the pancreas, proper allocation of pancreatic progenitors to endocrine and exocrine fates, and the production of digestive enzymes from the exocrine acini. In several neuronal structures, including the cerebellum, hindbrain, retina and spinal cord, Ptf1a is transiently expressed and promotes inhibitory neuron fates at the expense of excitatory fates...
September 15, 2013: Developmental Biology
A L McCall, L S Farhy
Type 1 diabetes is a disorder where slow destruction of pancreatic β-cells occurs through autoimmune mechanisms. The result is a progressive and ultimately complete lack of endogenous insulin. Due to β-cell lack, secondary abnormalities in glucagon and likely in incretins occur. These multiple hormonal abnormalities cause metabolic instability and extreme glycemic variability, which is the primary phenotype. As the disease progresses patients often develop hypoglycemia unawareness and defects in their counterregulatory defenses...
June 2013: Minerva Endocrinologica
Kun-Hee Kim, Hye-Jeong Park, Jin Hee Kim, Suhyun Kim, Darren R Williams, Myeong-Kyu Kim, Young Do Jung, Hiroki Teraoka, Hae-Chul Park, Hyon E Choy, Boo Ahn Shin, Seok-Yong Choi
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the unintentional byproduct of various industrial processes, is classified as human carcinogen and could disrupt reproductive, developmental and endocrine systems. Induction of cyp1a1 is used as an indicator of TCDD exposure. We sought to determine tissues that are vulnerable to TCDD toxicity using a transgenic zebrafish (Danio rerio) model. We inserted a nuclear enhanced green fluorescent protein gene (EGFP) into the start codon of a zebrafish cyp1a gene in a fosmid clone using DNA recombineering...
June 15, 2013: Aquatic Toxicology
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