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JOURNAL ARTICLE
Kavita Yadav, Raja Ramachandran, Vinod Kumar, Ashok K Yadav, Deeksha Pal, Natarajan Gopalakrishnan, Sourabh Sharma, P S Priyamvada, Arpita Lahiri, Manisha Sahay, Sree Bhushan Raju, M Sreelatha, R Manorajan, Pinaki Mukhopadhyay, Narayan Prasad, Priti Meena, Harbir S Kohli, Sanjay Vikrant, Vivekanand Jha
BACKGROUND AND AIM: Primary glomerular disease accounts for one-sixth of all chronic kidney diseases (CKDs) in India. We remain limited in our ability to effectively treat these conditions because of lack of understanding of the disease mechanisms and lack of predictors to identify the clinical course and therapeutic responsiveness. We propose to develop a network of investigators in glomerular diseases, collect information in a systematic fashion to understand the clinical outcomes, answer translational research questions better, and identify and recruit patients for clinical trials...
2023: Indian Journal of Nephrology
#22
JOURNAL ARTICLE
Prem S Patel, Prit P Singh, Amresh Krishna, Archana, Om Kumar
No abstract text is available yet for this article.
2023: Indian Journal of Nephrology
#23
JOURNAL ARTICLE
Edwin Fernando, Harshavardhan Trichy Sanathkumar, Aravind Ramanathan, N D Srinivasaprasad, K Thirumalvalavan, Poongodi Annadurai, S Sujith
BACKGROUND: Renal allograft rejection contributes to significant morbidity and graft loss. In this setting, early detection of rejection is of paramount importance, which currently relies on histopathology. A reliable non-invasive marker to predict rejection would make surveillance and decision-making easier. Donor-derived cell-free DNA (dd-Cf-DNA) has recently been reported as an emerging tool to predict rejection noninvasively. The utility of cell-free DNA in clinical practice has so far not been studied in an Indian setting...
2023: Indian Journal of Nephrology
#24
JOURNAL ARTICLE
Sukhwinder Sangha, Raj Kanwar Yadav, Arunkumar Subbiah, Soumita Bagchi, Sandeep Mahajan, Dipankar Bhowmik, Sanjay Kumar Agarwal
BACKGROUND: Diabetic kidney disease (DKD) is the commonest cause of end-stage renal disease (ESRD) across the world. Development of microalbuminuria is the earliest marker of DKD and predicts progressive decline in estimated glomerular filtration rate (eGFR). However, recent evidence has suggested that a significant proportion of type 2 diabetic patients have chronic kidney disease (CKD) without proteinuria. METHODS: In this single-center, prospective observational study, 400 consecutive type 2 diabetic patients with either overt proteinuria (>500 mg/day) and/or renal dysfunction eGFR <60 ml/min/1...
2023: Indian Journal of Nephrology
#25
Sanjay Maitra, Dhruva Maitra, Swarnalata Gowrishankar
Castleman disease (CD) comprises a rare group of heterogenous benign lymphoproliferative disorders with pathologic similarities. However, they present with diverse clinical manifestations. Renal involvement is rare in CD and is mainly reported with plasma cell type of multicentric disease. Various glomerular pathologies, interstitial involvement, or thrombotic microangiopathies have all been reported, some of which progress to end-stage renal disease (ESRD). Progression of CD to ESRD is well documented; however, a patient on dialysis developing CD is rare...
2023: Indian Journal of Nephrology
#26
JOURNAL ARTICLE
Sanjiv Jasuja, Maurizio Gallieni, Vivekanand Jha, Tushar Vachharajani, A K Bhalla, Jackson Tan, Cheih Suai Tan, Nabin Bahadur Basnet, Nalaka Herath, Ha Phan Hai An, Yong Soo Kim, Yaeni Kim, Krishnaswamy SampathKumar, Manisha Sahay, Raja Ramachandran, Suceena Alexander, Vinant Bhargava, J Balasubramaniam, David Voss, Fredeick E Ogbac, Atma Gunawan, Bak Leong Goh, Chih-Ching Lin, Jamshaid Khan, Ibrahim Shiham, Haroon Ayub, Min Aung Hein, Sarwar Iqbal, Nattachai Srisawat, Bihu Gao, Cherian Sajiv, Catherine Wilkinson, Thim Pichthida, D S Rana, Gaurav Sagar, Anupam Bahl, Samir Tawakley, Mragank Gaur
AIM: This cross-sectional survey aimed to determine the prevalence of Interventional Nephrology (IN) practice amongst nephrologists in the Asia-Pacific Region (APR), specifically related to dialysis access (DA). METHODS: The Association of VA and intervenTionAl Renal physicians (AVATAR) Foundation from India conducted a multinational online survey amongst nephrologists from the Asia-Pacific to determine the practice of IN in the planning, creation, and management of dialysis access...
September 11, 2023: Nephrology
#27
REVIEW
P S Vali, Namrata Parikh, Krithika Mohan, Urmila Anandh
Digital tools have revolutionized education in nephrology in India. All forms of in-person learning are moving online. Social media have taken over the world, with clinicians learning and promoting multidirectional education methods. E-learning is better equipped to keep up with the rapid pace of new knowledge generation and dissemination. The use of digital multimedia tools to enhance rapid learning is backed by science, viz., dual-coding theory. Digital tools such as Twitter, blogs, podcasts, YouTube, and Nephrology Simulator (NephSIM) have had an impact in facilitating nephrology education among medical professionals and the general public...
2023: Front Nephrol
#28
REVIEW
Mythri Shankar, Matthew A Sparks
Social media is defined as "a group of Internet-based applications that build on the ideological and technological foundations of Web 2.0, that allow the creation and exchange of user-generated content". Social media can be used in medical education to enhance knowledge sharing among peer groups and the public in general. The internet revolutionized learning by allowing easier dissemination of knowledge that did not depend on printing and physical distribution of books, journals, or magazines. According to a report from 2018, 95% of students have access to smartphones and 45% are online at any given time...
2023: Front Nephrol
#29
JOURNAL ARTICLE
Ranjit Singh, Majibullah Ansari, Namrata Rao, Abhilash Chandra, Shashwat Verma, Prabhaker Mishra, Ayush Lohiya
PURPOSE: Serum creatinine-based glomerular filtration rate (GFR) estimating equations are imprecise and systemic overestimate GFR in chronic kidney disease (CKD) populations with low muscle mass. Bioimpedance devices can measure body cell mass (BCM), a surrogate for muscle mass which has been included in a published GFR estimating equation. This BCM GFR equation is validated and compared with MDRD and CKD-EPI 2021 equations in an Indian CKD population. METHODS: Patients with stable CKD stages 1-5 and voluntary kidney donors underwent measurement of serum creatinine, DTPA GFR and bioimpedance on the same day...
August 31, 2023: International Urology and Nephrology
#30
JOURNAL ARTICLE
Shobhana Nayak-Rao
Chronic kidney disease (CKD) is a worldwide health problem affecting at least 10% of the world's population. CKD represents especially a large burden in low- to middle-income countries that are ill equipped to deal with its consequences. The burden of CKD is increasing in India as well. Although diabetes and hypertension account for much of this burden of CKD, there are regions where a surprisingly high rate of CKD of undetermined etiology (CKD-U) has been described in certain areas of the country. In our observational cross-sectional study, we attempted to look at burden and etiology of CKD in a predominantly rural referral center...
August 29, 2023: International Urology and Nephrology
#31
JOURNAL ARTICLE
Rupesh Raina, Sidharth Kumar Sethi, Gopal Agrawal, Sanjay Wazir, Naveen Bajaj, Naveen Parkash Gupta, Abhishek Tibrewal, Ananya Vadhera, Shishir Mirgunde, Binesh Balachandran, Jagdish Sahoo, Kamran Afzal, Anubha Shrivastava, Jyoti Bagla, Sushma Krishnegowda, Ananth Konapur, Kritika Soni, Khalid Alhasan, Mignon McCulloch, Timothy Bunchman
BACKGROUND: Diuretics are commonly used in neonatal AKI with the rationale to decrease positive fluid balance in critically sick neonates. The patterns of furosemide use vary among hospitals, which necessitates the need for a well-designed study. METHODS: The TINKER (The Indian Iconic Neonatal Kidney Educational Registry) study provides a database, spanning 14 centres across India since August 2018. Admitted neonates (≤ 28 days) receiving intravenous fluids for at least 48 h were included...
August 15, 2023: Pediatric Nephrology
#32
JOURNAL ARTICLE
Vidushi Mahajan, Anam Siddiqui, Anita Tahlan, Sanjay D 'Cruz, Shivani Jaiswal
UNLABELLED: We aimed to estimate the prevalence of anemia in children with nephrotic syndrome (NS), determine its etiology, and correlate severity with disease duration and response to steroids. This was a prospective cohort study carried from 15th July 2019-14th July 2021 at the pediatric nephrology clinic, of a teaching hospital in India. We screened children aged 3 months-18 years with NS for eligibility. We excluded those suffering from chronic kidney disease and, on haematinics...
October 2023: European Journal of Pediatrics
#33
JOURNAL ARTICLE
Elenjickal Elias John, Sanjeet Roy, Jeethu Joseph Eapen, Reka Karuppusami, Nisha Jose, Selvin Sundar Raj Mani, Joseph Johny, Rizwan Alam, Sabina Yusuf, Athul Thomas, Anna T Valson, Vinoi George David, Santosh Varughese, Suceena Alexander
AIM: Diabetic patients are prone to infections, thus making them a unique cohort at risk of developing bacterial infection-related glomerulonephritis (IRGN). METHODS: In total, 1693 adult diabetic patients underwent kidney biopsy between 2005 and 2021 at our tertiary care hospital in South India. Of these, 121 consecutive cases which met criteria of bacterial IRGN were included in this study. RESULTS: The mean age of the cohort was 53.1 ± 10...
July 26, 2023: Nephrology
#34
(no author information available yet)
[This corrects the article on p. 170 in vol. 33.].
2023: Indian Journal of Nephrology
#35
JOURNAL ARTICLE
Vivek Kute, Sonal Asthana, Subhash Gupta, Sanjay K Agarwal, G Swarnalatha, Manisha Sahay, Sujoy Pal, S Sudhindran, Ashish Sharma, Sandeep Seth, Alla Gopala Krishna Gokhale, Milind D Hote, Arpita R Chaudhury, Arvinder S Soin, Mohamed Rela, Rajesh Malhotra, Virinder K Bansal, Devinder S Rana, Vasanthi Ramesh
From the context of organ donation, COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is important as there is an ethical dilemma in utilizing versus discarding organs from potential donors succumbing to VITT. This consensus statement is an attempt by the National Organ and Tissue Transplant Organization (NOTTO) apex technical committees India to formulate the guidelines for deceased organ donation and transplantation in relation to VITT to help in appropriate decision making. VITT is a rare entity, but a meticulous approach should be taken by the Organ Procurement Organization's (OPO) team in screening such cases...
2023: Indian Journal of Nephrology
#36
JOURNAL ARTICLE
George T John, Chakko K Jacob, Madhivanan Sundaram, Suceena Alexander, Nitin S Kekre, Dolly Daniel, Santosh Varughese
No abstract text is available yet for this article.
2023: Indian Journal of Nephrology
#37
JOURNAL ARTICLE
Mamidi Neeraja, Sreedhar Kesireddy, Neerudi Raj Kumar, Madasu Praveen Kumar, Potlapally Pullaiah, Raju Chittampalli
INTRODUCTION: Recipient sensitization against donor human leukocyte antigens (HLA) plays a key role in transplant rejection, and this risk is best minimized by efficient pre transplant antibody detection. Determination of antibody specificity with the highest sensitivity and degree of resolution to the allelic antigen level is achieved by using single-antigen bead (SAB) assay. METHODS: This study evaluated the correlation of Luminex cross match (LXM) with SAB assay for detection of donor-specific antibodies (DSA)...
2023: Indian Journal of Nephrology
#38
JOURNAL ARTICLE
Malsawmkima Chhakchhuak, Manish Chaturvedy, Jony Agarwal, Vibhor Tak, Nitin K Bajpai
INTRODUCTION: Hemodialysis patients are at risk of infections. This study examines the spectrum of infections and antibiotic resistance patterns. METHODS: We retrospectively reviewed the records of 586 hemodialysis patients from May 2018 to April 2020 in a tertiary care hospital in North India. RESULTS: The study identified 99 episodes of confirmed infections. Urinary tract infections were the most common type of infections (55.5%), followed by catheter-related bloodstream infections (CRBSI) (definitive 21...
2023: Indian Journal of Nephrology
#39
JOURNAL ARTICLE
Vivekanand Jha, Alan Almeida, Arpita R Choudhury, Arup R Dutta, Dinesh Khullar, Gokulnath, Urmila Anandh, Umesh Khanna, Vijay Kher
Despite the availability of multiple therapies for chronic kidney disease (CKD), there still exists an unmet need for better options to slow down disease progression and prevent complications. The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial, which demonstrated the renoprotective effects of the sodium-glucose cotransporter-2 inhibitor (SGLT2i) dapagliflozin, independent of diabetes, with improved survival, even in patients with CKD with estimated glomerular filtration rate (eGFR) as low as 25 mL/min/1...
October 2022: Journal of the Association of Physicians of India
#40
REVIEW
H K Chopra, G S Wander, C K Ponde, Navin C Nanda, Dinesh Khullar, K Venugopal, Saumitra Ray, Tiny Nair, D S Rana, Vijay Kher, J P S Sawhney, R R Kasliwa, A Jabir, Rabin Chakraborty, Praveen Chandra, Sandeep Bansal, Viveka Kumar, A K Pancholia, Aditya Kapoor, Sunil Prakash, Anil Saxena, Vishal Rastogi, Vinod Sharma, Y K Arora, Arup Dasbiswas, Mohan Bhargava, Aparna Jaswal, K Bhargava, Mona Bhatia, A K Omar, N N Khanna, Rajiv Passey, Dilip Bhalla, I B Vijayalakshmi, A K Bhalla, Asha Moorthy, H S Isser, S S Mishra, S N Routray, Vivek Tandon, Ajay Sinha, Manish Bansal, Praveen Jain, Ramesh Hotchandani, Dharmendra Jain, V K Katyal, Sanjiv Gulati, Rohit Tandon, Shalini Jaggi, Blessy Sehgal, Vitull Gupta, Rahul Mehrotra, N C Krishnamani, S N Pathak, M S Yadav, Rajeev Chawla, Jyotirmoy Pal, Nandini Chatterjee, Shambo S Samajdar, N R Shastry
;Heart failure (HF) is a huge global public health task due to morbidity, mortality, disturbed quality of life, and major economic burden. It is an area of active research and newer treatment strategies are evolving. Recently angiotensin receptor-neprilysin inhibitor (ARNI), a class of drugs (the first agent in this class, Sacubitril-Valsartan), reduces cardiovascular mortality and morbidity in chronic HF patients with reduced left ventricular ejection fraction (LVEF). Positive therapeutic effects have led to a decrease in cardiovascular mortality and HF hospitalizations (HFH), with a favorable safety profile, and have been documented in several clinical studies with an unquestionable survival benefit with ARNI, Sacubitril-Valsartan...
February 2023: Journal of the Association of Physicians of India
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