keyword
https://read.qxmd.com/read/38515042/the-kidney-histopathological-spectrum-of-patients-with-kidney-injury-following-snakebite-envenomation-in-india-scoping-review-of-five-decades
#1
JOURNAL ARTICLE
Priti Meena, Vinant Bhargava, Pallav Gupta, Sandip Panda, Soumyadeep Bhaumik
INTRODUCTION: Snakebite is a public health problem leading to about 58,000 deaths every year in India. Kidney injury subsequent to snakebite envenomation is common with a reported prevalence of up to 32%. The current study aims to elucidate the spectrum of kidney histopathology in acute kidney injury (AKI) cases associated with snake bites. METHODS: We searched seven electronic database studies to identify studies describing the histopathological findings in the kidney with snakebite envenomation...
March 21, 2024: BMC Nephrology
https://read.qxmd.com/read/38465112/retrospective-analysis-of-potential-adverse-drug-interactions-in-the-drugs-prescribed-to-the-elderly-at-a-tertiary-health-care-center-in-raipur-chhattisgarh-central-india
#2
JOURNAL ARTICLE
Yazhini Rajendran, Yogendra Keche, Nitin R Gaikwad, Suryaprakash Dhaneria
Background The elderly population differs from adults in having various physiological changes and multiple diseases, which demand the use of multiple medications. The practice of polypharmacy in the elderly leads to numerous harmful effects like adverse drug reactions, adverse drug-drug interactions (DDIs), poor compliance, etc. Methodology This study collected 295 case files of elderly patients retrospectively in the Departments of General Medicine, Cardiology and Nephrology after obtaining Institute Ethics Committee approval to look for the potential adverse DDIs with their severity according to the clinical significance...
February 2024: Curēus
https://read.qxmd.com/read/38396436/artificial-intelligence-in-kidney-disease-a-comprehensive-study-and-directions-for-future-research
#3
REVIEW
Chieh-Chen Wu, Md Mohaimenul Islam, Tahmina Nasrin Poly, Yung-Ching Weng
Artificial intelligence (AI) has emerged as a promising tool in the field of healthcare, with an increasing number of research articles evaluating its applications in the domain of kidney disease. To comprehend the evolving landscape of AI research in kidney disease, a bibliometric analysis is essential. The purposes of this study are to systematically analyze and quantify the scientific output, research trends, and collaborative networks in the application of AI to kidney disease. This study collected AI-related articles published between 2012 and 20 November 2023 from the Web of Science...
February 12, 2024: Diagnostics
https://read.qxmd.com/read/38317681/community-acquired-acute-kidney-injury-in-india-data-from-isn-acute-kidney-injury-registry
#4
JOURNAL ARTICLE
Narayan Prasad, Akhilesh Jaiswal, Jeyakumar Meyyappan, Natrajan Gopalakrishnan, Arpita Roy Chaudhary, Edwin Fernando, Manish Rathi, Shivendra Singh, Mohan Rajapurkar, Tarun Jeloka, Jai Kishun, Valentine Lobo
BACKGROUND: Acute kidney injury (AKI), particularly community-acquired AKI (CA-AKI), is a major health concern globally. The International Society of Nephrology's "0 by 25" initiative to reduce preventable deaths from AKI to zero by 2025 is not achievable in low and middle income countries, such as India, possibly due to a lack of data and measures to tackle this urgent public health issue. In India, CA-AKI predisposes younger patients to hospitalization, morbidity, and mortality. This is the first multicenter, prospective, cohort study investigating CA-AKI and its consequences in India...
February 2024: Lancet Reg Health Southeast Asia
https://read.qxmd.com/read/38294522/new-insights-from-the-genetic-work-up-in-early-onset-nephrotic-syndrome-report-from-a-registry-in-western-india
#5
JOURNAL ARTICLE
Jyoti Sharma, Anshuman Saha, Alpana Ohri, Vaishali More, Fagun Shah, Jalpa Dave, Brinda Panchal Jain, Manoj Matnani, K Sathe, Pankaj Bhansali, Puneet Chhajed, Pawan Deore, Nivedita Pande, Chintan Shah, Vala Kinnari, Jyoti Singhal, Nisha Krishnamurthy, Meenal Agarwal, Uma Ali
BACKGROUND: Eighty-five percent of infants with congenital nephrotic syndrome (CNS) and 66% with infantile NS (INS) are likely to have a monogenic etiology. There exists a significant genetic variability between different regions and ethnic groups. This study aimed to determine the genetic defects in children with CNS and INS by establishing a registry in western India. METHODS: In this cross-sectional study, pediatric nephrologists from 13 private and government institutions shared relevant clinical data and details of the genetic evaluation of children presenting with NS within the first year of life...
January 31, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38230297/cryptococcosis-in-kidney-transplant-recipients-current-understanding-and-practices
#6
REVIEW
Priti Meena, Vinant Bhargava, Kulwant Singh, Jasmine Sethi, Aniketh Prabhakar, Sandip Panda
Cryptococcosis is the third most commonly occurring invasive fungal disease in solid organ transplant recipients (SOT). It is caused by encapsulated yeast, Cryptococcus species, predominantly Cryptococcus neoformans and Cryptococcus gattii. Though kidney transplant recipients are at the lowest risk of cryptococcosis when compared to other solid organ transplant recipients such as lung, liver or heart, still this opportunistic infection causes significant morbidity and mortality in this subset of patients. Mortality rates with cryptococcosis range from 10%-25%, while it can be as high as 50% in SOT recipients with central nervous system involvement...
December 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/38156781/variation-in-performing-kidney-biopsy-amongst-nephrologists-in-the-asia-pacific-region-a-multinational-survey
#7
JOURNAL ARTICLE
Sanjiv Jasuja, Vivekanand Jha, Maurizio Gallieni, Devinder S Rana, Tushar Vachharajani, Gaurav Sagar, Anupam Bahl, Samir Tawakley, Mragank Gaur
AIM: Kidney biopsy (KB) is the gold standard procedure for diagnosing kidney diseases. Globally, nephrologists are trained to perform KB. However, the past few decades have witnessed a transition where interventional radiologists (IRs) are now preferentially performing the procedure. Our survey-based cross-sectional study aimed to investigate the current trends of KB operators in the Asia-Pacific region (APR) in practicing interventional nephrologists. MATERIAL AND METHODS: The Association of Vascular Access and intervenTionAl Renal Physicians (AVATAR) Foundation from India conducted a multinational online survey among interventional nephrologists from the APR to investigate who does KB, if the nephrology training curriculum includes KB, and whether nephrologists have access to ultrasound...
December 29, 2023: Clinical Nephrology
https://read.qxmd.com/read/38034151/deranged-biochemical-markers-as-early-predictors-for-the-development-of-hepatorenal-syndrome-in-patients-with-alcoholic-liver-cirrhosis
#8
JOURNAL ARTICLE
Durga Deorukhkar, Archana Sonawale, Aman Goyal, Kshitij Sonawale
Objective To investigate predictive biomarkers correlated with the onset of hepatorenal syndrome (HRS) in individuals with alcoholic liver cirrhosis using various factors, including age, sex, and laboratory indicators such as serum sodium, bilirubin, PT/INR, and albumin levels. Additionally, we sought to establish a correlation between the occurrence of hepatic encephalopathy (HE), spontaneous bacterial peritonitis (SBP), and the model for end-stage liver disease (MELD) score at the time of diagnosis and the development of HRS in cirrhotic patients...
October 2023: Curēus
https://read.qxmd.com/read/37914965/clinical-characteristics-genetic-profile-and-short-term-outcomes-of-children-with-primary-hyperoxaluria-type-2-a-nationwide-experience
#9
JOURNAL ARTICLE
Sudarsan Krishnasamy, Bobbity Deepthi, Nivedita Kamath, Arpana Iyengar, Christy Cathreen Thomas, Susan Uthup, Anshuman Saha, Georgie Mathew, Indira Agarwal, Karalanglin Tiewsoh, Nowneet Kumar Bhat, Kausik Mandal, Sriram Krishnamurthy
BACKGROUND: Three types of primary hyperoxaluria (PH) are recognized. However, data on PH type 2 (PH2), caused by defects in the GRHPR gene, are limited. METHODS: We reviewed the medical records of patients < 18 years of age with genetically-proven PH2 from seven centres across India to identify the age of onset, patterns of clinical presentation, short-term outcomes and genetic profile, and to determine if genotype-phenotype correlation exists. RESULTS: We report 20 patients (all with nephrolithiasis or nephrocalcinosis) diagnosed to have PH2 at a median (IQR) age of 21...
November 2, 2023: Pediatric Nephrology
https://read.qxmd.com/read/37881748/granulomatous-spondylodiscitis-as-a-rare-manifestation-of-brucellosis-in-a-patient-on-maintenance-hemodialysis-from-india
#10
JOURNAL ARTICLE
Umesha Lingaraj, C G Sreedhara, Bhushan C Shetty, Kishan Aralapuram, Megha Pai, Mythri Shankar
No abstract text is available yet for this article.
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37881737/a-novel-mutation-in-gata3-gene-in-a-case-of-hypoparathyroidism-deafness-and-renal-dysplasia-syndrome
#11
Pooja Prakash Prabhu, Sudarshan Ballal, Rohan Augustine, Mitesh Shetty
A 39-year-old male was incidentally detected to have hypertension and chronic kidney disease (CKD) with left solitary functioning kidney in 2017. He has bilateral sensorineural hearing loss since adolescence. He was initially suspected to have adynamic bone disease in view of low parathyroid hormone levels and was started on teriparatide injections and calcium supplements. Despite all these measures, he had persistent hypocalcemia and low parathyroid hormone levels. Hence, Hypoparathyroidism, Deafness, and Renal dysplasia (HDR) syndrome was suspected, and the patient was evaluated for the same...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37881735/changing-tides-of-acute-interstitial-nephritis-a-retrospective-observational-study-from-south-india
#12
JOURNAL ARTICLE
Mythri Shankar, Sreedhara C Gurusiddaiah, Seeta Mutalik, Kishan Aralapuram
INTRODUCTION: The incidence of acute interstitial nephritis (AIN) has been increasing in recent years. The causes and outcomes of AIN have been changing with time and vary widely based on geographical region. METHODS: A retrospective observational study was conducted in a tertiary care center. All ( n = 6234) native kidney biopsies were reviewed from January 2016 to December 2021. All biopsy-proven AIN cases were included in the study. AIN associated with systemic diseases (such as SLE, Sjogren's, sarcoidosis, plasma cell dyscrasias), proliferative glomerulonephritis, and allograft biopsies were excluded...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37881731/transition-of-kidney-care-at-18-challenges-and-practical-solutions-for-india
#13
REVIEW
Niveditha Girimaji, Priya Pais, Arpana Iyengar
Health-care transition (HCT) from pediatric-centered to adult-oriented health-care setting is more than a simple transfer of care. It is a carefully planned movement specially tailored for the needs of adolescents and young adults (AYAs). Similar to other chronic diseases, the need for HCT for AYAs with kidney disease has been well established by the International Society of Nephrology (ISN) and the International Pediatric Nephrology Association (IPNA) consensus statements since 2011. However, successful HCT in India and other low- and middle-income countries (LMICs) has been limited...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37870264/parakid-navigating-the-relation-between-paraproteins-and-kidney-lesions-a-multi-center-retrospective-observational-study
#14
MULTICENTER STUDY
Mythri Shankar, Urmila Anandh, Swarnalatha Guditi
INTRODUCTION: Monoclonal gammopathy is a heterogeneous group of disorders due to the clonal proliferation of immunoglobulin-producing plasma cells or B lymphocytes. Patients develop kidney disease not only due to malignant transformation but also due to the idiosyncratic properties of the M protein and the host factors. We aim to study the spectrum of kidney diseases in patients with paraproteinemia. MATERIALS AND METHODS: A retrospective observational study was performed at three tertiary care centers in Southern India...
December 2023: Clinical Nephrology
https://read.qxmd.com/read/37842396/measured-glomerular-filtration-rate-in-live-related-kidney-donors-three-months-post-kidney-donation-a-single-center-experience-from-western-india
#15
JOURNAL ARTICLE
Abhijit S Chavan, Charan B Bale, Pavan S Wakhare, Nilesh Shinde, Akshay R Kulkarni, Atul D Sajgure, Tushar A Dighe
Background Glomerular filtration rate (GFR) estimation is pivotal in the evaluation of kidney donors. There are various methods available for assessing GFR, but there has been a lack of consensus on the measurement of GFR and the frequency of renal evaluation after kidney donation. Our study aims to analyze the measured GFR (m-GFR) before and three months after kidney donation and note the compensatory abilities of the remnant kidney in live related kidney donors. Methods This prospective observational study was conducted at the Department of Nephrology, Dr...
September 2023: Curēus
https://read.qxmd.com/read/37781560/indian-translational-glomerulonephritis-biology-network-i-tangible-design-and-methods
#16
JOURNAL ARTICLE
Kavita Yadav, Raja Ramachandran, Vinod Kumar, Ashok K Yadav, Deeksha Pal, Natarajan Gopalakrishnan, Sourabh Sharma, P S Priyamvada, Arpita Lahiri, Manisha Sahay, Sree Bhushan Raju, M Sreelatha, R Manorajan, Pinaki Mukhopadhyay, Narayan Prasad, Priti Meena, Harbir S Kohli, Sanjay Vikrant, Vivekanand Jha
BACKGROUND AND AIM: Primary glomerular disease accounts for one-sixth of all chronic kidney diseases (CKDs) in India. We remain limited in our ability to effectively treat these conditions because of lack of understanding of the disease mechanisms and lack of predictors to identify the clinical course and therapeutic responsiveness. We propose to develop a network of investigators in glomerular diseases, collect information in a systematic fashion to understand the clinical outcomes, answer translational research questions better, and identify and recruit patients for clinical trials...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37781557/nephrotic-syndrome-with-acute-kidney-injury-after-covaxin-bbv152-covid-19-vaccination-a-case-from-india
#17
JOURNAL ARTICLE
Prem S Patel, Prit P Singh, Amresh Krishna, Archana, Om Kumar
No abstract text is available yet for this article.
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37781552/donor-derived-cell-free-dna-and-active-rejection-in-renal-allografts
#18
JOURNAL ARTICLE
Edwin Fernando, Harshavardhan Trichy Sanathkumar, Aravind Ramanathan, N D Srinivasaprasad, K Thirumalvalavan, Poongodi Annadurai, S Sujith
BACKGROUND: Renal allograft rejection contributes to significant morbidity and graft loss. In this setting, early detection of rejection is of paramount importance, which currently relies on histopathology. A reliable non-invasive marker to predict rejection would make surveillance and decision-making easier. Donor-derived cell-free DNA (dd-Cf-DNA) has recently been reported as an emerging tool to predict rejection noninvasively. The utility of cell-free DNA in clinical practice has so far not been studied in an Indian setting...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37781550/clinical-profile-of-nonproteinuric-kidney-disease-in-type-2-diabetic-patients-in-india
#19
JOURNAL ARTICLE
Sukhwinder Sangha, Raj Kanwar Yadav, Arunkumar Subbiah, Soumita Bagchi, Sandeep Mahajan, Dipankar Bhowmik, Sanjay Kumar Agarwal
BACKGROUND: Diabetic kidney disease (DKD) is the commonest cause of end-stage renal disease (ESRD) across the world. Development of microalbuminuria is the earliest marker of DKD and predicts progressive decline in estimated glomerular filtration rate (eGFR). However, recent evidence has suggested that a significant proportion of type 2 diabetic patients have chronic kidney disease (CKD) without proteinuria. METHODS: In this single-center, prospective observational study, 400 consecutive type 2 diabetic patients with either overt proteinuria (>500 mg/day) and/or renal dysfunction eGFR <60 ml/min/1...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37781546/successful-renal-transplant-in-castleman-disease-first-case-report-from-india
#20
Sanjay Maitra, Dhruva Maitra, Swarnalata Gowrishankar
Castleman disease (CD) comprises a rare group of heterogenous benign lymphoproliferative disorders with pathologic similarities. However, they present with diverse clinical manifestations. Renal involvement is rare in CD and is mainly reported with plasma cell type of multicentric disease. Various glomerular pathologies, interstitial involvement, or thrombotic microangiopathies have all been reported, some of which progress to end-stage renal disease (ESRD). Progression of CD to ESRD is well documented; however, a patient on dialysis developing CD is rare...
2023: Indian Journal of Nephrology
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