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https://www.readbyqxmd.com/read/29228118/where-is-the-tmt-gc-ms-analyses-of-fox-feces-and-behavioral-responses-of-rats-to-fear-inducing-odors
#1
Olivier Rampin, Nathalie Jerôme, Audrey Saint-Albin, Christian Ouali, Frank Boué, Nicolas Meunier, Birte L Nielsen
TMT (2,5-dihydro-2,4,5-trimethylthiazoline) is known as a component of fox feces inducing fear in rodents. However, no recent chemical analyses of fox feces are available, and few studies make direct comparisons between TMT and fox feces. Fox feces from 3 individuals were used to prepare 24 samples to be analyzed for the presence of TMT using gas chromatography-mass spectrometry (GC-MS). When TMT was added in low amounts (50-2000 nmol/g), TMT was detected in 10 out of 11 samples. When no TMT was added, TMT was detected in only 1 out of 13 samples...
December 8, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29227306/big-data-analytical-approaches-to-the-nacc-dataset-aiding-preclinical-trial-enrichment
#2
Ming Lin, Pinghua Gong, Tao Yang, Jieping Ye, Roger L Albin, Hiroko H Dodge
BACKGROUND: Clinical trials increasingly aim to retard disease progression during presymptomatic phases of Mild Cognitive Impairment (MCI) and thus recruiting study participants at high risk for developing MCI is critical for cost-effective prevention trials. However, accurately identifying those who are destined to develop MCI is difficult. Collecting biomarkers is often expensive. METHODS: We used only noninvasive clinical variables collected in the National Alzheimer's Coordinating Center (NACC) Uniform Data Sets version 2...
December 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29226177/color-discrimination-errors-associate-with-axial-motor-impairments-in-parkinson-s-disease
#3
Nicolaas I Bohnen, Jacob Haugen, Andrew Ridder, Vikas Kotagal, Roger L Albin, Kirk A Frey, Martijn L T M Müller
Background: Visual function deficits are more common in imbalance-predominant compared to tremor-predominant PD suggesting a pathophysiological role of impaired visual functions in axial motor impairments. Objective: To investigate the relationship between changes in color discrimination and motor impairments in PD while accounting for cognitive or other confounder factors. Methods: PD subjects (n=49, age 66.7±8.3 years; Hoehn & Yahr stage 2...
November 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/29224231/ultrastructural-aspects-of-hairs-of-chediak-higashi-syndrome
#4
H L de Almeida, A E Kiszewski, T Vicentini Xavier, F Pirolli, L A Suíta de Castro
Chediak-Higashi syndrome (CHS) belongs to a group of partial oculocutaneous albinism and immunodeficiency. Five autosomal recessive conditions are recognized in this group, characterized by hypopigmentation of hair, skin and eyes, associated with recurrent infections. Additionally CHS can present coagulopathies, neurological dysfunction and large granules in many cell types. This article is protected by copyright. All rights reserved.
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29208014/plasma-c4d-as-marker-for-lupus-nephritis-in-systemic-lupus-erythematosus
#5
Myriam Martin, Karolina I Smoląg, Albin Björk, Birgitta Gullstrand, Marcin Okrój, Jonatan Leffler, Andreas Jönsen, Anders A Bengtsson, Anna M Blom
BACKGROUND: In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). METHODS: C4d levels were determined by enzyme-linked immunosorbent assay in plasma samples of patients with established SLE using a novel approach based on detection of a short linear cleavage neoepitope. Cross-sectional associations were studied in 98 patients with SLE with samples taken at lower or higher respective disease activity...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29204917/the-outcome-of-cochlear-implantation-among-children-with-genetic-syndromes
#6
Farid Alzhrani, Rayan Alhussini, Rawan Hudeib, Tuqa Alkaff, Tahera Islam, Abdulrahman Alsanosi
OBJECTIVE: To assess the outcome and efficacy of cochlear implantation in children with genetic syndromes. METHOD: Study design: case-control study. SETTING: A cochlear implantation tertiary referral center. PATIENTS: All pediatric cochlear implantation recipients with Waardenburg syndrome, Usher syndrome, Dandy-Walker syndrome, or albinism. A control group was appropriately matched to the syndromic group with regard to age at implantation and duration of device use...
December 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29204293/validity-reliability-and-feasibility-of-commercially-available-activity-trackers-in-physical-therapy-for-people-with-a-chronic-disease-a-study-protocol-of-a-mixed-methods-research
#7
Emmylou Beekman, Susy M Braun, Darcy Ummels, Kim van Vijven, Albine Moser, Anna J Beurskens
Background: For older people and people with a chronic disease, physical activity provides health benefits. Patients and healthcare professionals can use commercially available activity trackers to objectively monitor (alterations in) activity levels and patterns and to support physical activity. However, insight in the validity, reliability, and feasibility of these trackers in people with a chronic disease is needed. In this article, a study protocol is described in which the validity, reliability (part A), and feasibility from a patient and therapist's point of view (part B) of commercially available activity trackers in daily life and health care is investigated...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29202616/series-practical-guidance-to-qualitative-research-part-4-trustworthiness-and-publishing
#8
Irene Korstjens, Albine Moser
In the course of our supervisory work over the years we have noticed that qualitative research tends to evoke a lot of questions and worries, so-called frequently asked questions (FAQs). This series of four articles intends to provide novice researchers with practical guidance for conducting high-quality qualitative research in primary care. By 'novice' we mean Master's students and junior researchers, as well as experienced quantitative researchers who are engaging in qualitative research for the first time...
December 5, 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/29199486/series-practical-guidance-to-qualitative-research-part-3-sampling-data-collection-and-analysis
#9
Albine Moser, Irene Korstjens
In the course of our supervisory work over the years, we have noticed that qualitative research tends to evoke a lot of questions and worries, so-called frequently asked questions (FAQs). This series of four articles intends to provide novice researchers with practical guidance for conducting high-quality qualitative research in primary care. By 'novice' we mean Master's students and junior researchers, as well as experienced quantitative researchers who are engaging in qualitative research for the first time...
December 4, 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/29187504/tissue-specific-gene-inactivation-in%C3%A2-xenopus-laevis-knockout-of%C3%A2-lhx1%C3%A2-in-the-kidney-with-crispr-cas9
#10
Bridget D DeLay, Mark E Corkins, Hannah L Hanania, Matthew Salanga, Jian Min Deng, Norihiro Sudou, Masanori Taira, Marko Horb, Rachel K Miller
Studying genes involved in organogenesis is often difficult because many of these genes are also essential for early development. The allotetraploid frog, Xenopus laevis, is commonly used to study developmental processes, but because of the presence of two homeologs for many genes, it has been difficult to use as a genetic model. Few studies have successfully used CRISPR in amphibians, and currently there is no tissue-targeted knockout strategy described in Xenopus The goal of this study is to determine whether CRISPR/Cas9-mediated gene knockout can be targeted to the Xenopus kidney without perturbing essential early gene function...
November 29, 2017: Genetics
https://www.readbyqxmd.com/read/29186482/alr-encoding-dcmp-deaminase-is-critical-for-dna-damage-repair-cell-cycle-progression-and-plant-development-in-rice
#11
Mei Niu, Yihua Wang, Chunming Wang, Jia Lyu, Yunlong Wang, Hui Dong, Wuhua Long, Di Wang, Weiyi Kong, Liwei Wang, Xiuping Guo, Liting Sun, Tingting Hu, Huqu Zhai, Haiyang Wang, Jianmin Wan
Deoxycytidine monophosphate deaminase (dCMP deaminase, DCD) is crucial to the production of dTTP needed for DNA replication and damage repair. However, the effect of DCD deficiency and its molecular mechanism are poorly understood in plants. Here, we isolated and characterized a rice albinic leaf and growth retardation (alr) mutant that is manifested by albinic leaves, dwarf stature and necrotic lesions. Map-based cloning and complementation revealed that ALR encodes a DCD protein. OsDCD was expressed ubiquitously in all tissues...
November 24, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29185831/series-practical-guidance-to-qualitative-research-part-1-introduction
#12
Albine Moser, Irene Korstjens
In the course of our supervisory work over the years, we have noticed that qualitative research tends to evoke a lot of questions and worries, so-called Frequently Asked Questions. This journal series of four articles intends to provide novice researchers with practical guidance for conducting high-quality qualitative research in primary care. By 'novice' we mean Master's students and junior researchers, as well as experienced quantitative researchers who are engaging in qualitative research for the first time...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/29185826/series-practical-guidance-to-qualitative-research-part-2-context-research-questions-and-designs
#13
Irene Korstjens, Albine Moser
In the course of our supervisory work over the years, we have noticed that qualitative research tends to evoke a lot of questions and worries, so-called frequently asked questions (FAQs). This series of four articles intends to provide novice researchers with practical guidance for conducting high-quality qualitative research in primary care. By 'novice' we mean Master's students and junior researchers, as well as experienced quantitative researchers who are engaging in qualitative research for the first time...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/29182044/prerequisites-and-driving-forces-behind-an-extended-working-life-among-older-workers
#14
Pia Hovbrandt, Carita Håkansson, Maria Albin, Gunilla Carlsson, Kerstin Nilsson
BACKGROUND: Reforms are changing pension systems in many European countries, in order to both restrict early retirement and force people to extend their working life. From occupational therapy and occupational science perspectives, studies focusing on aspects of working life that motivate the older worker is urgent. AIM: The aim was to describe incentives behind an extended working life among people over age 65. METHOD: Focus group methodology was used, with participants ages 66-71, from varying work fields: construction and technical companies and the municipal elderly care sector...
November 28, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29180933/implementation-of-an-enhanced-recovery-after-surgery-eras-protocol-in-a-gynaecology-department-the-follow-up-at-1-year
#15
Tomasz Nikodemski, Agnieszka Biskup, Aleksandra Taszarek, Małgorzata Albin, Anita Chudecka-Głaz, Aneta Cymbaluk-Płoska, Janusz Menkiszak
Aim of the study: An ERAS protocol provides the latest perioperative care principles, whose primary aim is to reduce complication rates, and therefore mortality. The aim of this study is to establish the progress of the ERAS pathway implementation in our gynaecology department. Material and methods: This was a retrospective analysis of two sets of 100 consecutive medical records: patients treated before (PRE-ERAS) and after (ERAS) introduction of the ERAS protocol...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29179261/targeted-base-editing-via-rna-guided-cytidine-deaminases-in-xenopus-laevis-embryos
#16
Dong-Seok Park, Mijung Yoon, Jiyeon Kweon, An-Hee Jang, Yongsub Kim, Sun-Cheol Choi
Genome editing using programmable nucleases such as CRISPR/Cas9 or Cpf1 has emerged as powerful tools for gene knock-out or knock-in in various organisms. While most genetic diseases are caused by point mutations, these genome-editing approaches are inefficient in inducing single-nucleotide substitutions. Recently, Cas9-linked cytidine deam-inases, named base editors (BEs), have been shown to convert cytidine to uridine efficiently, leading to targeted single-base pair substitutions in human cells and organisms...
November 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29161625/prediction-of-walk-to-run-transition-using-stride-frequency-a-test-retest-reliability-study
#17
Ernst Albin Hansen, Andreas Møller Nielsen, Lasse Andreas Risgaard Kristensen, Pascal Madeleine, Michael Voigt
The transition from walking to running has previously been predicted to occur at a point where the stride frequency starts getting closer to the running attractor than to the walking attractor. The two behavioural attractors were considered to be represented by the freely chosen stride frequencies during unrestricted treadmill walking and running. The aim of the present study was to determine the relative and absolute test-retest reliability of the predicted walk-to-run transition stride frequency. Healthy individuals (n=25) performed walking and running on a treadmill in a day-to-day test-retest design...
November 18, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29161433/jaspar-2018-update-of-the-open-access-database-of-transcription-factor-binding-profiles-and-its-web-framework
#18
Aziz Khan, Oriol Fornes, Arnaud Stigliani, Marius Gheorghe, Jaime A Castro-Mondragon, Robin van der Lee, Adrien Bessy, Jeanne Chèneby, Shubhada R Kulkarni, Ge Tan, Damir Baranasic, David J Arenillas, Albin Sandelin, Klaas Vandepoele, Boris Lenhard, Benoît Ballester, Wyeth W Wasserman, François Parcy, Anthony Mathelier
No abstract text is available yet for this article.
November 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29141312/-clinical-manifestation-and-gene-analyses-of-15-patients-with-intellectual-disability-or-developmental-delay-complicated-with-congenital-nystagmus
#19
Z J Gao, Q Jiang, Q Chen, K M Xu, Z Q Liu, X B Chen, X L Chen
Objective: To analyze the clinical and genetic features of 15 cases with intellectual disability or developmental delay (ID/DD) complicated with congenital nystagmus. Method: The clinical characteristics and the results of laboratory tests, images and genetics of 15 patients with ID/DD complicated with congenital nystagmus, confirmed by gene diagnosis in the Department of Neurology, Children's Hospital Affiliated to Capital Institute of Pediatrics from March 2015 to October 2016, were retrospectively analyzed...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29140473/jaspar-2018-update-of-the-open-access-database-of-transcription-factor-binding-profiles-and-its-web-framework
#20
Aziz Khan, Oriol Fornes, Arnaud Stigliani, Marius Gheorghe, Jaime A Castro-Mondragon, Robin van der Lee, Adrien Bessy, Jeanne Chèneby, Shubhada R Kulkarni, Ge Tan, Damir Baranasic, David J Arenillas, Albin Sandelin, Klaas Vandepoele, Boris Lenhard, Benoît Ballester, Wyeth W Wasserman, François Parcy, Anthony Mathelier
JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across multiple species in six taxonomic groups. In the 2018 release of JASPAR, the CORE collection has been expanded with 322 new PFMs (60 for vertebrates and 262 for plants) and 33 PFMs were updated (24 for vertebrates, 8 for plants and 1 for insects). These new profiles represent a 30% expansion compared to the 2016 release...
November 13, 2017: Nucleic Acids Research
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