Yulu Chen, Antonio Checa, Pei Zhang, Mengna Huang, Rachel S Kelly, Min Kim, Yih-Chieh S Chen, Kathleen A Lee-Sarwar, Nicole Prince, Kevin M Mendez, Sofina Begum, Priyadarshini Kachroo, Su H Chu, Jakob Stokholm, Klaus Bønnelykke, Augusto A Litonjua, Hans Bisgaard, Scott T Weiss, Bo L Chawes, Craig E Wheelock, Jessica A Lasky-Su
BACKGROUND: While dysregulated sphingolipid metabolism has been associated with risk of childhood asthma, the specific sphingolipid classes and/or mechanisms driving this relationship remain unclear. We aimed to understand the multifaceted role between sphingolipids and other established asthma risk factors that complicate this relationship. METHODS: We performed targeted LC-MS/MS-based quantification of 77 sphingolipids in plasma from 997 children aged 6 years from two independent cohorts (VDAART and COPSAC2010 )...
February 2024: Allergy