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Asthma and Vitamin D

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https://www.readbyqxmd.com/read/29142554/vitamin-d-supplementation-improves-fev1-in-patients-of-bronchial-asthma
#1
Muhammad Zafar Majeed Babar, Mazhar Hussain, Sadia Abdul Majeed
Background and Objective: Vitamin D deficiency has strong association with various respiratory disorders in which bronchial asthma is one of them. The objective was to determine the efficacy of vitamin D supplementation in cases with bronchial asthma. Methods: This case control study was conducted at private clinical set up of district, Rahim Yar Khan from August to October 2016 in which 100 cases of bronchial asthma were randomly divided into Group-A and Group-B each contained 50 patients...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29137124/asthmatic-patients-with-vitamin-d-deficiency-have-decreased-exacerbations-after-vitamin-replacement
#2
Paolo Solidoro, Michela Bellocchia, Ilaria Aredano, Alessio Mattei, Emanuele Pivetta, Filippo Patrucco, Monica Boita, Francesca de Blasio, Luisa Brussino, Giovanni Rolla, Caterina Bucca
BACKGROUND: Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL. METHODS: Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29124699/asthma-and-allergy-epidemic-and-the-role-of-vitamin-d-deficiency
#3
Konstantinos Douros, Barbara Boutopoulou, Sotirios Fouzas, Ioanna Loukou
The increase in asthma and allergies prevalence that has been recorded in many countries during the last decades, and the reemergence of vitamin D (VD) deficiency in many populations worldwide, renders fairly plausible the assumption of an underlying association between these two conditions and justifies the research effort invented in this issue. Indeed, there is growing body of evidence from epidemiological, laboratory, and clinical studies, suggesting that such an association does exist. The hypothesis of low levels of VD leading to compromised fetal programming and impairment of various immune functions involved in asthma and allergic disorders, stands as the most credible explanation of this presumed association...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29123222/the-independent-effects-of-vitamin-d-deficiency-and-house-dust-mite-exposure-on-lung-function-are-sex-specific
#4
Nailê K Nuñez, Ellen Bennett, Ling Chen, Paulo Márcio Pitrez, Graeme R Zosky
Vitamin D deficiency is increasing around the world and has been associated with the development of asthma. This study aims to evaluate the effect of dietary vitamin D deficiency at different life stages on lung function using a murine model of allergic airways disease. BALB/c mice were challenged intranasally with HDM or saline alone for 10 days. Twenty four hours after the last challenge, mice were anesthetized and lung function was measured using the forced oscillation technique (FOT). Mice were euthanized for assessment of inflammation in the bronchoalveolar lavage (BAL) and total collagen content in lung homogenates by ELISA...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116314/what-do-cochrane-systematic-reviews-say-about-interventions-for-vitamin-d-supplementation
#5
Mariana Vendramin Mateussi, Carolina de Oliveira Cruz Latorraca, Júlia Pozetti Daou, Ana Luiza Cabrera Martimbianco, Rachel Riera, Rafael Leite Pacheco, Daniela Vianna Pachito
CONTEXT AND OBJECTIVE: Despite the high prevalence of vitamin D supplementation, its use remains controversial. The objective of this review was to identify and summarize the evidence from Cochrane systematic reviews regarding vitamin D supplementation for preventing ortreating any clinical condition. DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo...
November 6, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29112181/vitamin-d-supplementation-in-respiratory-diseases-evidence-from-rct
#6
Carolien Mathyssen, Ghislaine Gayan-Ramirez, Roger Bouillon, Wim Janssens
Pulmonary diseases are one of the most important causes for morbidity and mortality. Although vitamin D is best known for its role in calcium, phosphorus and bone homeostasis, in the recent years vitamin D has gained attention because of a wide range of extra-skeletal effects including its immunomodulatory and antibacterial potential. Vitamin D deficiency is highly prevalent in chronic pulmonary diseases such as Chronic Obstructive Pulmonary Disease (COPD), cystic fibrosis, tuberculosis and asthma and several clinical studies have been conducted investigating the effect of vitamin D supplementation on disease outcomes...
November 2, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29111213/prenatal-and-early-life-triclosan-and-parabens-exposure-and-allergic-outcomes
#7
Kathleen Lee-Sarwar, Russ Hauser, Antonia M Calafat, Xiaoyun Ye, George T O'Connor, Megan Sandel, Leonard B Bacharier, Robert S Zeiger, Nancy Laranjo, Diane R Gold, Scott T Weiss, Augusto A Litonjua, Jessica H Savage
BACKGROUND: In cross-sectional studies, triclosan and parabens, ubiquitous ingredients in personal care and other products, are associated with allergic disease. OBJECTIVES: We investigated the association between prenatal and early life triclosan and parabens exposure and childhood allergic disease in a prospective, longitudinal study. METHODS: Subjects were enrollees in VDAART, the Vitamin D Antenatal Asthma Reduction Trial. Triclosan, methyl paraben and propyl paraben concentrations were quantified in maternal plasma samples pooled from first and third trimesters and urine samples from children at age 3 or 4 years...
October 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29102433/effect-of-vitamin-d-supplementation-on-non-skeletal-disorders-a-systematic-review-of-meta-analyses-and-randomised-trials
#8
REVIEW
Philippe Autier, Patrick Mullie, Alina Macacu, Miruna Dragomir, Magali Boniol, Kim Coppens, Cécile Pizot, Mathieu Boniol
Randomised trials reported up to Dec 31, 2012, did not confirm that vitamin D supplementation could protect from non-skeletal health conditions affecting adults, as was expected on the basis of data from observational studies. To examine whether the more recently published meta-analyses and trials would change past conclusions, we systematically reviewed meta-analyses of vitamin D supplementation and non-skeletal disorders published between Jan 1, 2013, and May 31, 2017, that included study participants of all ages, including pregnant women...
October 25, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29077711/prenatal-vitamin-d-supplementation-reduces-risk-of-asthma-recurrent-wheeze-in-early-childhood-a-combined-analysis-of-two-randomized-controlled-trials
#9
Helene M Wolsk, Bo L Chawes, Augusto A Litonjua, Bruce W Hollis, Johannes Waage, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Scott T Weiss
BACKGROUND: We recently published two independent randomized controlled trials of vitamin D supplementation during pregnancy, both indicating a >20% reduced risk of asthma/recurrent wheeze in the offspring by 3 years of age. However, neither reached statistical significance. OBJECTIVE: To perform a combined analysis of the two trials and investigate whether maternal 25-hydroxy-vitamin D (25(OH)D) level at trial entry modified the intervention effect. METHODS: VDAART (N = 806) and COPSAC2010...
2017: PloS One
https://www.readbyqxmd.com/read/29055500/long-term-systemic-corticosteroid-exposure-a-systematic-literature-review
#10
REVIEW
J Bradford Rice, Alan G White, Lauren M Scarpati, George Wan, Winnie W Nelson
PURPOSE: While corticosteroids are relatively inexpensive and commonly used as treatment for a variety of conditions, long-term use is known to be associated with certain toxicities. Prior systematic reviews have revealed an increased risk for costly adverse events (AEs), including bone fracture, infection, and gastrointestinal bleeding. The objective of this study was to conduct a systematic literature review of recent publications on the burden of long-term corticosteroid exposure, specifically, to summarize the AEs and economic impact of long-term corticosteroid use and to reveal data gaps for additional research...
October 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29046037/vitamin-d-and-asthma-in-clinical-practice-the-impact-on-asthma-control
#11
Giorgio Ciprandi, Fabio Gallo
No abstract text is available yet for this article.
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28986128/vitamin-d-supplementation-to-prevent-asthma-exacerbations-a-systematic-review-and-meta-analysis-of-individual-participant-data
#12
David A Jolliffe, Lauren Greenberg, Richard L Hooper, Christopher J Griffiths, Carlos A Camargo, Conor P Kerley, Megan E Jensen, David Mauger, Iwona Stelmach, Mitsuyoshi Urashima, Adrian R Martineau
BACKGROUND: A previous aggregate data meta-analysis of randomised controlled trials showed that vitamin D supplementation reduces the rate of asthma exacerbations requiring treatment with systemic corticosteroids. Whether this effect is restricted to patients with low baseline vitamin D status is unknown. METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016...
November 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28986127/vitamin-d-and-asthma-a-case-to-answer
#13
Richard Beasley, Mark Weatherall
No abstract text is available yet for this article.
October 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28965301/minimal-trauma-ankle-fractures-predominate-during-pregnancy-a-17-year-retrospective-study
#14
Madhuni Herath, Phillip Wong, Anne Trinh, Carolyn A Allan, Euan M Wallace, Peter R Ebeling, Peter J Fuller, Frances Milat
This study assessed all fractures occurring in pregnancy at a tertiary referral centre over a 17-year period. Most fractures were due to minimal trauma, and those involving the ankle were the most common. Women tended to fracture during their second and third trimesters and most required surgical intervention during pregnancy. PURPOSE: To characterise fractures in pregnancy over a 17-year period at a tertiary referral health service. METHODS: Medical records at the Monash Health in Australia were examined from 2000-2016 for fractures in pregnancy using the birthing outcome system database and the tenth revision of the International Statistical Classification of Diseases and Related Health Problems coding...
September 30, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28925648/vitamin-d-for-the-management-of-asthma
#15
Juan Qiu
No abstract text is available yet for this article.
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28923762/vitamin-d-in-asthma-mechanisms-of-action-and-considerations-for-clinical-trials
#16
REVIEW
Paul E Pfeffer, Catherine M Hawrylowicz
There is increasing interest in the therapeutic utility of vitamin D in asthma, which is supported by a significant body of evidence on epidemiologic associations between vitamin D insufficiency and worse asthma control. In support of a causal relationship, vitamin D beneficially modulates diverse immunologic pathways in heterogeneous asthma endotypes, regulating the actions of lymphocytes, mast cells, antigen-presenting cells, and structural cells to dampen excessive inflammatory responses. Allergic asthma is characterized by a failure of immune tolerance and the development of pathologic responses to inhaled aeroallergens, and vitamin D has been extensively shown to support immune regulation...
September 18, 2017: Chest
https://www.readbyqxmd.com/read/28923490/the-association-of-maternal-asthma-and-early-pregnancy-vitamin-d-with-risk-of-preeclampsia-an-observation-from-vitamin-d-antenatal-asthma-reduction-trial-vdaart
#17
Hooman Mirzakhani, Vincent J Carey, Thomas F McElrath, Nancy Laranjo, George O'Connor, Ronald E Iverson, Aviva Lee-Parritz, Robert C Strunk, Leonard B Bacharier, George A Macones, Robert S Zeiger, Michael Schatz, Bruce W Hollis, Augusto A Litonjua, Scott T Weiss
BACKGROUND: Maternal asthma, uncontrolled asthma, and low vitamin D levels during pregnancy have been individually linked to increased risk of preeclampsia. OBJECTIVE: To investigate the association of history of physician-diagnosed asthma and uncontrolled asthma status during pregnancy with the risk of preeclampsia and the effects of early pregnancy vitamin D concentrations on this relationship. METHODS: A total of 816 subjects with available pregnancy outcome data and risk factors of interest were analyzed...
September 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28901968/medical-comorbidity-in-polycystic-ovary-syndrome-with-special-focus-on-cardiometabolic-autoimmune-hepatic-and-cancer-diseases-an-updated-review
#18
Dorte Glintborg, Marianne Andersen
PURPOSE OF REVIEW: Polycystic ovary syndrome (PCOS) is defined by hyperandrogenism, irregular menses and polycystic ovaries when other causes are excluded. The possible implication of increased morbidity in PCOS for screening and follow-up is uncertain and is reviewed in this article. RECENT FINDINGS: The increased risk of type 2 diabetes and cardiovascular disease in PCOS is closely associated with BMI. Women with PCOS should be screened for the elements of the metabolic syndrome upon diagnosis...
December 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28863873/evaluation-of-the-associations-between-immunoglobulin-e-levels-and-the-number-of-natural-teeth
#19
Kyungdo Han, Eunjoo Lee, Jun-Beom Park
BACKGROUND/PURPOSE: The purpose of the study was to evaluate the association between the number of natural teeth and the total serum immunoglobulin E (IgE), allergen-specific IgE against Dermatophagoides farina, allergen-specific IgE against cockroaches, or allergen-specific IgE against dogs with nationally representative data using the Korean National Health and Nutrition Examination Survey (KNHANES). METHODS: This study involved a cross-sectional analysis using KNHANES data from 2010...
August 29, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28846076/a-new-combination-therapy-for-asthma-using-dual-function-dexamethsone-conjugated-polyethylenimine-and-vitamin-d-binding-protein-sirna
#20
M Choi, J Gu, M Lee, T Rhim
Asthma is a multifactorial disease that is influenced by the interaction of genetic and environmental factors. Due to its complex nature, there is no cure for asthma currently. Instead, reliever and controller medications are used to treat asthma. Unfortunately, conventional treatments do not work in some severe cases of asthma. In addition, there may be adverse, systemic effects of long-term treatment with high-dose inhaled corticosteroids as a controller medication. Therefore, we attempted to develop a novel combination therapy for asthma...
August 28, 2017: Gene Therapy
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