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Asthma and Vitamin D

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https://www.readbyqxmd.com/read/28105733/vitamin-d-supplementation-for-sickle-cell-disease
#1
REVIEW
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28100331/-hmgb1-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-and-role-of-vitamin-d-in-asthmatic-mice
#2
Jun-Ying Qiao, Li Song, Yan-Li Zhang, Bin Luan
OBJECTIVE: To investigate the changes in the mRNA and protein expression of high-mobility group box 1 (HMGB1), Toll-like receptor 4 (TLR4), and nuclear factor-kappa B (NF-κB) in lung tissues of asthmatic mice and the interventional effect of vitamin D. METHODS: A total of 48 BALB/c mice were randomly divided into control group, asthma group, and 1,25-(OH)2D3 intervention group, with 16 mice in each group. An animal model of asthma was established, and lung tissue samples were taken in each group at weeks 1 and 2 of ovalbumin challenging...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28092390/asthma-comparing-the-impact-of-vitamin-d-versus-uvr-on-clinical-and-immune-parameters
#3
Kylie A Morgan, Elizabeth H Mann, Antony R Young, Catherine M Hawrylowicz
The incidence of asthma has increased markedly since the 1960s and is currently estimated to affect more than 300 million individuals worldwide. A number of environmental factors are implicated in asthma pathogenesis, one of which is vitamin D. Vitamin D deficiency is a global health concern and has increased in parallel with asthma incidence. Epidemiological studies report associations between low vitamin D status, assessed as circulating levels of 25-hydroxyvitamin D, with asthma incidence, severity, exacerbations and responses to treatment...
January 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28079560/prenatal-exposures-and-the-development-of-childhood-wheezing-illnesses
#4
Christian Rosas-Salazar, Tina V Hartert
PURPOSE OF REVIEW: To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS: The aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes...
January 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28079559/strategies-to-alter-the-natural-history-of-childhood-asthma
#5
K A Lee-Sarwar, L B Bacharier, A A Litonjua
PURPOSE OF REVIEW: Asthma exhibits significant heterogeneity in occurrence and severity over the lifespan. Our goal is to discuss recent evidence regarding determinants of the natural history of asthma during childhood, and review the rationale behind and status of major efforts to alter its course. RECENT FINDINGS: Variations in microbial exposures are associated with risk of allergic disease, and the use of bacterial lysates may be a promising preventive strategy...
January 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28017448/25-hydroxyvitamin-d-concentrations-asthma-and-eczema-in-childhood-the-generation-r-study
#6
Ilse I M Tromp, Oscar H Franco, Edith H van den Hooven, Annemieke C Heijboer, Vincent W V Jaddoe, Liesbeth Duijts, Johan C de Jongste, Henriëtte A Moll, Jessica C Kiefte-de Jong
BACKGROUND & AIMS: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children...
December 8, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28012936/results-of-daily-oral-dosing-with-up-to-60-000-international-units-iu-of-vitamin-d3-for-2-to-6-years-in-3-adult-males
#7
REVIEW
Patrick McCullough, Jeffrey Amend
In the 1930's and 1940's, vitamin D was reported to be an effective treatment for a number of diseases, including asthma, psoriasis, rheumatoid arthritis, rickets and tuberculosis. High doses were used, 60,000 to 300,000 IU a day for asthma, and 200,000 to 600,000 IU a day for rheumatoid arthritis. Toxicity from hypercalcemia occurred after prolonged oral dosing with these supraphysiologic doses. Assays for measuring vitamin D in the blood were not available, and blood levels of vitamin D associated with hypercalcemia were unknown...
December 21, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28003380/control-of-circulating-ige-by-the-vitamin-d-receptor-in-vivo-involves-b-cell-intrinsic-and-extrinsic-mechanisms
#8
Jamaal James, Veronika Weaver, Margherita T Cantorna
Vitamin D deficiency is associated with the development of asthma and allergy. The active form of vitamin D [1,25(OH)2D] regulates B cells in vitro and mice without the vitamin D receptor (VDR knockout [KO]) have high serum IgE. Whole-body VDR KO, T cell-specific VDR (T-VDR) KO, B cell-specific VDR (B-VDR) KO, and vitamin D deficient mice were used to determine the targets of vitamin D in the regulation of IgE in vivo. Vitamin D deficient, VDR KO, and B-VDR KO mice developed hyper-IgE, whereas T-VDR KO mice did not...
December 21, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27993535/jaci-editorial-vitamin-d-status-through-the-first-10-years-of-life-a-vital-piece-of-the-puzzle-in-asthma-inception
#9
EDITORIAL
Augusto A Litonjua, Scott T Weiss
No abstract text is available yet for this article.
December 16, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27987538/vitamin-d-deficiency-and-its-impact-on-asthma-severity-in-asthmatic-children
#10
Nasrin Esfandiar, Fariba Alaei, Shahrzad Fallah, Delara Babaie, Niloofar Sedghi
BACKGROUND: Despite obtaining evidences on association between vitamin D and development of lung in fetus, little is known about vitamin D level and its impact on severity of asthma in children. The present study aimed to assess the relationship between the asthma severity and vitamin D deficiency in asthmatic children. METHODS: This case-control study was conducted on 106 individuals including asthmatic (n = 53) and healthy children (n = 53) who referred to Mofid hospital in Tehran in 2013...
December 17, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27981740/maternal-vitamin-d-status-during-pregnancy-and-risk-of-childhood-asthma%C3%A0-a-meta-analysis-of-prospective-studies
#11
Huihui Song, Lei Yang, Chongqi Jia
SCOPE: Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma. METHODS AND RESULTS: A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma...
December 16, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27974898/serum-vitamin-d-levels-and-vitamin-d-supplement-in-adult-patients-with-asthma-exacerbation
#12
Tadech Boonpiyathad, Teerapol Chantveerawong, Panitan Pradubpongsa, Atik Sangasapaviliya
Introduction. Vitamin D deficiency has been linked to an increased risk of asthma exacerbations. Objective. This study aimed to compare vitamin D status during the period of severe asthma exacerbations and investigate if vitamin D supplementation improves asthma control. Methods. A total of 47 asthmatic patients and 40 healthy subjects participated in this study. Serum 25-hydroxyvitamin D (25(OH)D), asthma control test (ACT) score, and % predicted peak expiratory flow rate were evaluated in the period with and without severe asthma exacerbations...
2016: Journal of Allergy
https://www.readbyqxmd.com/read/27964949/vitamin-d-and-the-lung
#13
REVIEW
Sofia Konstantinopoulou, Ignacio E Tapia
Vitamin D metabolism is complex and its deficiency has proven to be deleterious in bone health, and to have significant effects on the immune and cardiovascular systems. Vitamin D has also been associated with pulmonary diseases outcomes. This review will focus on vitamin D metabolism, and studies performed mostly in children with asthma or Cystic Fibrosis.
October 31, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27955890/the-relation-of-innate-and-adaptive-immunity-with-viral-induced-acute-asthma-attacks-focusing-on-ip-10-and-cathelicidin
#14
T Arikoglu, E Akyilmaz, D D Yildirim, S B Batmaz, S T Ulger, G Aslan, S Kuyucu
BACKGROUND: Despite growing evidence suggesting potential association between innate and adaptive immunity in viral-induced acute asthma, there is paucity of data in this area. OBJECTIVE: This study aimed to investigate the association of innate and adaptive immunity with acute asthma attacks by analysing the role of IFN-γ-inducible protein 10 (IP-10), TLR2, cathelicidin, vitamin D and cytokines. MATERIAL AND METHODS: This prospective study included 33 patients with viral-induced acute asthma and 30 children with controlled asthma...
December 9, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27939043/periostin-the-bone-and-beyond
#15
REVIEW
L Idolazzi, E Ridolo, A Fassio, D Gatti, M Montagni, M Caminati, I Martignago, C Incorvaia, G Senna
In recent years the relationship between bone, metabolism and many pathophysiologic mechanisms involving other organs and the immune system, was increasingly apparent. This observation concerns vitamin D, osteopontin and periostin (PO). PO is expressed in the periosteum of long bones but also in many other tissues and organs, including heart, kidney, skin and lungs, being enhanced by mechanical stress or injury. PO has a relevant physiological function in promoting injury repair in a large number of tissues...
December 6, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27913247/vitamin-d-insufficiency-and-asthma-in-a-us-nationwide-study
#16
Yueh-Ying Han, Erick Forno, Juan C Celedón
BACKGROUND: Vitamin D insufficiency (a serum 25-hydroxy vitamin D level of <30 ng/mL) has been associated with asthma morbidity. OBJECTIVE: To examine vitamin D insufficiency, asthma, and lung function among US children and adults. METHODS: Using data from the National Health and Nutrition Examination Survey from 2001 to 2010, we examined vitamin D insufficiency and (1) current asthma or wheeze in 10,860 children (6-17 years) and 24,115 adults (18-79 years) and (2) lung function in a subset of participants...
November 29, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27902981/calcitriol-reduces-eosinophil-necrosis-which-leads-to-the-diminished-release-of-cytotoxic-granules
#17
Caroline Ethier, Yingqi Yu, Lisa Cameron, Paige Lacy, Francis Davoine
BACKGROUND: Asthma severity and eosinophilia correlate with a deficiency in vitamin D and its active metabolite calcitriol. Calcitriol modulates numerous leukocyte functions, but its effect on eosinophils is not fully understood. We postulated that calcitriol exerts a direct effect on eosinophil biology by modulating cell survival. METHODS: Purified peripheral blood eosinophils from atopic donors were incubated in the presence of calcitriol for up to 14 days with or without IL-5...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27867307/adequate-vitamin-d-intake-but-low-serum-levels-in-pediatric-asthma-patients-a-pilot-study-alberta-children-s-hospital
#18
Sarah Howe McKenna, Tanis R Fenton, Mary Noseworthy, Mark Anselmo
Background. We assessed vitamin D intakes and serum 25(OH) vitamin D levels in pediatric asthma patients on moderate-to-high dose inhaled steroids and compared them to published findings of healthy children in our city. Methods. Parents and/or patients were interviewed to estimate the children's vitamin D intakes from foods and supplements (using an adapted validated food frequency questionnaire) and asthma duration and management. Vitamin D status: serum 25-hyroxy vitamin D (25(OH)D) was obtained from the medical records...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27826434/development-and-piloting-of-a-food-based-intervention-to-increase-vitamin-e-intake-in-pregnant-women-in-a-randomized-controlled-trial
#19
Julia Clark, Nikki Holgan, Leone Craig, Heather Morgan, Peter Danielian, Graham Devereux
Low maternal vitamin E intake during pregnancy is associated with childhood asthma and a trial is required to test whether increasing maternal vitamin E intake reduces childhood asthma. This study investigated whether such a trial is possible using food to increase vitamin E intake. Three soup varieties with enhanced vitamin E content (16-19 mg/can) from food ingredients were developed. Near identical retail versions (vitamin E 1-4 mg/can) acted as placebo. In a pilot double-blind randomized controlled trial, pregnant women were randomized 1:1 to enhanced or placebo soups (three tins/week) from 12 weeks gestation to delivery...
November 2016: Food Science & Nutrition
https://www.readbyqxmd.com/read/27825992/prevalence-determinants-and-clinical-correlates-of-vitamin-d-deficiency-in-adults-with-inhaled-corticosteroid-treated-asthma-in-london-uk
#20
REVIEW
David A Jolliffe, Kate Kilpin, Beverley D MacLaughlin, Claire L Greiller, Richard L Hooper, Neil C Barnes, Peter M Timms, Raj K Rajakulasingam, Angshu Bhowmik, Aklak B Choudhury, David E Simcock, Elina Hyppönen, Christopher J Corrigan, Robert T Walton, Christopher J Griffiths, Adrian R Martineau
Vitamin D deficiency is common in children with asthma, and it associates with poor asthma control, reduced forced expiratory volume in one second (FEV1) and increased requirement for inhaled corticosteroids (ICS). Cross-sectional studies investigating the prevalence, determinants and clinical correlates of vitamin D deficiency in adults with asthma are lacking. We conducted a multi-centre cross-sectional study in 297 adults with a medical record diagnosis of ICS-treated asthma living in London, UK. Details of potential environmental determinants of vitamin D status, asthma control and medication use were collected by questionnaire; blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction, and participants underwent measurement of weight, height and fractional exhaled nitric oxide concentration (FeNO), spirometry and sputum induction for determination of lower airway eosinophil counts (n=35 sub-group)...
November 5, 2016: Journal of Steroid Biochemistry and Molecular Biology
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