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Asthma and Vitamin D

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https://www.readbyqxmd.com/read/28925648/vitamin-d-for-the-management-of-asthma
#1
Juan Qiu
No abstract text is available yet for this article.
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28923762/translating-basic-research-into-clinical-practice-vitamin-d-in-asthma-mechanisms-of-action-and-considerations-for-clinical-trials
#2
REVIEW
Paul E Pfeffer, Catherine M Hawrylowicz
There is increasing interest in the therapeutic utility of vitamin D in asthma, supported by a significant body of evidence on epidemiological associations between vitamin D insufficiency and worse asthma control. In support of a causal relationship, vitamin D beneficially modulates diverse immunological pathways in heterogeneous asthma endotypes, regulating the actions of lymphocytes, mast cells, antigen-presenting cells and structural cells to dampen excessive inflammatory responses. Allergic asthma is characterised by a failure of immune tolerance, and development of pathological responses to inhaled aeroallergens, and vitamin D has been extensively shown to support immune regulation...
September 15, 2017: Chest
https://www.readbyqxmd.com/read/28923490/the-association-of-maternal-asthma-and-early-pregnancy-vitamin-d-with-risk-of-preeclampsia-an-observation-from-vitamin-d-antenatal-asthma-reduction-trial-vdaart
#3
Hooman Mirzakhani, Vincent J Carey, Thomas F McElrath, Nancy Laranjo, George O'Connor, Ronald E Iverson, Aviva Lee-Parritz, Robert C Strunk, Leonard B Bacharier, George A Macones, Robert S Zeiger, Michael Schatz, Bruce W Hollis, Augusto A Litonjua, Scott T Weiss
BACKGROUND: Maternal asthma, uncontrolled asthma, and low vitamin D levels during pregnancy have been individually linked to increased risk of preeclampsia. OBJECTIVE: To investigate the association of history of physician-diagnosed asthma and uncontrolled asthma status during pregnancy with the risk of preeclampsia and the effects of early pregnancy vitamin D concentrations on this relationship. METHODS: A total of 816 subjects with available pregnancy outcome data and risk factors of interest were analyzed...
September 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28901968/medical-comorbidity-in-polycystic-ovary-syndrome-with-special-focus-on-cardiometabolic-autoimmune-hepatic-and-cancer-diseases-an-updated-review
#4
Dorte Glintborg, Marianne Andersen
PURPOSE OF REVIEW: Polycystic ovary syndrome (PCOS) is defined by hyperandrogenism, irregular menses and polycystic ovaries when other causes are excluded. The possible implication of increased morbidity in PCOS for screening and follow-up is uncertain and is reviewed in this article. RECENT FINDINGS: The increased risk of type 2 diabetes and cardiovascular disease in PCOS is closely associated with BMI. Women with PCOS should be screened for the elements of the metabolic syndrome upon diagnosis...
September 8, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28863873/evaluation-of-the-associations-between-immunoglobulin-e-levels-and-the-number-of-natural-teeth
#5
Kyungdo Han, Eunjoo Lee, Jun-Beom Park
BACKGROUND/PURPOSE: The purpose of the study was to evaluate the association between the number of natural teeth and the total serum immunoglobulin E (IgE), allergen-specific IgE against Dermatophagoides farina, allergen-specific IgE against cockroaches, or allergen-specific IgE against dogs with nationally representative data using the Korean National Health and Nutrition Examination Survey (KNHANES). METHODS: This study involved a cross-sectional analysis using KNHANES data from 2010...
August 29, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28846076/a-new-combination-therapy-for-asthma-using-dual-function-dexamethsone-conjugated-polyethylenimine-and-vitamin-d-binding-protein-sirna
#6
M Choi, J Gu, M Lee, T Rhim
Asthma is a multifactorial disease that is influenced by the interaction of genetic and environmental factors. Due to its complex nature, there is no cure for asthma currently. Instead, reliever and controller medications are used to treat asthma. Unfortunately, conventional treatments do not work in some severe cases of asthma. In addition, there may be adverse, systemic effects of long-term treatment with high-dose inhaled corticosteroids as a controller medication. Therefore, we attempted to develop a novel combination therapy for asthma...
August 28, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28835366/vitamin-d-prenatal-programming-of-childhood-metabolomics-profiles-at-age-3-y
#7
Kevin Blighe, Bo L Chawes, Rachel S Kelly, Hooman Mirzakhani, Michael McGeachie, Augusto A Litonjua, Scott T Weiss, Jessica A Lasky-Su
Background: Vitamin D deficiency is implicated in a range of common complex diseases that may be prevented by gestational vitamin D repletion. Understanding the metabolic mechanisms related to in utero vitamin D exposure may therefore shed light on complex disease susceptibility.Objective: The goal was to analyze the programming role of in utero vitamin D exposure on children's metabolomics profiles.Design: First, unsupervised clustering was done with plasma metabolomics profiles from a case-control subset of 245 children aged 3 y with and without asthma from the Vitamin D Antenatal Asthma Reduction Trial (VDAART), in which pregnant women were randomly assigned to vitamin D supplementation or placebo...
August 23, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28830802/impact-of-vitamin-d-deficiency-on-increased-blood-eosinophil-counts
#8
João Tadeu Damian Souto Filho, Alícia Souza de Andrade, Felipe Mesquita Ribeiro, Paola de Araujo Sardenberg Alves, Virgínia Ribeiro Fernandes Simonini
OBJECTIVE/BACKGROUND: Vitamin D has been increasingly recognized as an immunomodulatory agent. Its deficiency has been associated with immune-mediated diseases such as asthma, rhinitis, and atopic dermatitis. These allergic conditions are dependent on T-helper type 2 (Th2) cells secreting interleukins, overproduction of immunoglobulin E (IgE), and eosinophil activation. We investigated the association between serum vitamin D levels and blood absolute eosinophil count. METHODS: We carried out a cross-sectional study of 669 men and women referred to a clinical pathology laboratory who underwent 25-hydroxyvitamin D testing and complete blood count analysis on the same day...
August 16, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28826280/severe-therapy-resistant-asthma-in-children-translational-approaches-to-uncover-sub-phenotypes
#9
Aldara Martin Alonso, Valentina Fainardi, Sejal Saglani
Paediatric severe therapy resistant asthma (STRA) affects a very small proportion of all children with asthma, but results in significant morbidity, has a high risk of mortality and utilises approximately half of all healthcare resources for childhood asthma. children with STRA need add-on 'beyond guidelines' therapies because of poor control despite maximal conventional treatments and optimisation of basic asthma management. however, STRA is heterogeneous with marked phenotypic variation between patients and mechanisms from adult severe asthma cannot be extrapolated to children...
August 21, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28815786/vitamin-d-intake-during-the-first-4%C3%A2-years-and-onset-of-asthma-by-age-5-a-nested-case-control-study
#10
Bright I Nwaru, Kishor Hadkhale, Niina Hämäläinen, Hanna-Mari Takkinen, Suvi Ahonen, Jorma Ilonen, Jorma Toppari, Onni Niemelä, Anna-Maija Haapala, Riitta Veijola, Mikael Knip, Suvi M Virtanen
BACKGROUND: Early-life vitamin D intake has been linked to asthma risk in childhood, but the role of longitudinal vitamin D exposure has not been previously evaluated. We investigated the association between vitamin D intake during the first 4 years of life and asthma risk by age 5. METHODS: Within a Finnish population-based birth cohort, 182 incident asthma cases were matched to 728 controls on sex, genetic risk for type 1 diabetes, delivery hospital, and time of birth...
August 17, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28775375/the-relationship-between-maternal-25-hydroxyvitamin-d-status-in-pregnancy-and-childhood-adiposity-and-allergy-an-observational-study
#11
V T Boyle, E B Thorstensen, J M D Thompson, L M E McCowan, E A Mitchell, K M Godfrey, L Poston, C R Wall, R Murphy, W Cutfield, T Kenealy, L C Kenny, P N Baker
BACKGROUND: Vitamin D insufficiency (defined as <75 nmol/l) is widespread amongst pregnant women around the world and has been proposed to influence offspring outcomes in childhood and into adult life, including adiposity and allergy. Disorders including asthma and eczema are on the rise amongst children. Our aim was to investigate the relationship between maternal 25-hydroxyvitamin D status in pregnancy and offspring adiposity, asthma and eczema in childhood. SUBJECTS AND METHODS: Maternal 25-hydroxyvitamin D concentrations were analysed in serum samples collected at 15 weeks' gestation from 1710 participants of the prospective Screening for Pregnancy Endpoints (SCOPE) cohort study...
August 4, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28775219/assessment-of-dietary-food-and-nutrient-intake-and-bone-density-in-children-with-eczema
#12
T F Leung, S S Wang, F Y Kwok, L W Leung, C M Chow, E K Hon
INTRODUCTION: Dietary restrictions are common among patients with eczema, and such practice may lead to diminished bone mineral density. This study investigated dietary intake and bone mineral density in Hong Kong Chinese children with eczema. METHODS: This cross-sectional and observational study was conducted in a university-affiliated teaching hospital in Hong Kong. Chinese children aged below 18 years with physician-diagnosed eczema were recruited from our paediatric allergy and dermatology clinics over a 6-month period in 2012...
August 4, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28757230/vitamin-d-high-sensitivity-c-reactive-protein-and-airway-hyperresponsiveness-in-infants-with-recurrent-respiratory-symptoms
#13
Anette M Määttä, Anne Kotaniemi-Syrjänen, Kristiina Malmström, L Pekka Malmberg, Jouko Sundvall, Anna S Pelkonen, Mika J Mäkelä
BACKGROUND: Vitamin D insufficiency might be associated with biased T-cell responses resulting in inflammatory conditions such as atopy and asthma. Little is known about the role of vitamin D in low-grade systemic inflammation and airway hyperresponsiveness (AHR) in young children. OBJECTIVE: To evaluate whether vitamin D insufficiency and increased serum high-sensitivity C-reactive protein (hs-CRP) are linked to AHR in symptomatic infants. METHODS: Seventy-nine infants with recurrent or persistent lower respiratory tract symptoms underwent comprehensive lung function testing and a bronchial methacholine challenge test...
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28749460/asthma-and-allergy-vitamin-d-primes-neonatal-immune-system
#14
Yvonne Bordon
No abstract text is available yet for this article.
July 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28737861/effects-of-25-hydroxy-vitamin-d-levels-on-the-severity-and-asthma-control-in-school-age-asthma-patients
#15
Merve Havan, Cem H Razi, Ayse D Bulus, Ali O Köksal, Nesibe Andıran
BACKGROUND: The objective was to determine vitamin D levels in patients between the ages 6 and 18 years, followed for asthma, and the relation between vitamin D levels and asthma control and severity. MATERIALS AND METHODS: Patients with asthma and healthy volunteers between the ages 6 and 18 years were enrolled into the study as patient and control groups, respectively. Patient demographic information and clinical findings were recorded; a respiratory function test was performed...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28736267/gamma-tocopherol-enriched-supplement-reduces-sputum-eosinophilia-and-endotoxin-induced-sputum-neutrophilia-in-volunteers-with-asthma
#16
Allison J Burbank, Charity G Duran, Yinghao Pan, Patricia Burns, Susan Jones, Qing Jiang, Chao Yang, Sha'Leema Jenkins, Heather Wells, Neil Alexis, Mehmet Kesimer, William D Bennett, Haibo Zhou, David B Peden, Michelle L Hernandez
BACKGROUND: We and others have shown that the gamma tocopherol (γT) isoform of vitamin E has multiple anti-inflammatory and antioxidant actions and that γT supplementation reduces eosinophilic and endotoxin (LPS)-induced neutrophilic airway inflammation in animal models and healthy human volunteers. OBJECTIVE: We sought to determine whether γT supplementation reduces eosinophilic airway inflammation and acute neutrophilic response to inhaled LPS challenge in volunteers with asthma...
July 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28730377/influence-of-vitamin-d-and-cotinine-on-t-regulatory-cells-and-asthma-severity-in-children
#17
Bolesław Kalicki, Agata Wawrzyniak, Agnieszka Lipińska-Opałka, Sławomir Lewicki, Robert Zdanowski
Asthma is a common chronic respiratory diseases in children. Understanding the immune mechanisms of epigenetic factors may contribute to a better control of asthma. This study seeks to determine the effects of serum vitamin D and urine cotinine on asthma severity and on T regulatory cells (Tregs) and other immune-related factors such as CD3, CD4, CD8, CD19, CD16/56, and anti-CD3 HLA-DR3. The study involved 34 children with asthma. Disease severity was assessed with the Asthma Control Test, spirometry, and the fractional exhaled nitric oxide (FeNO)...
July 21, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28724883/calcium-prepartions-do-not-inhibit-allergic-reactions-a-randomized-controlled-trial
#18
Klaudia Matysiak, Michał Matuszewski, Wojciech Feleszko
INTRODUCTION    Massive consumption of dietary supplements, including vitamins and minerals, has recently became a serious public issue in Europe. When ingested, they may negatively affect pharmacological activity of various medications, including anti-allergic drugs. Calcium preparations are well-known and commonly used in some European countries as a popular remedy for allergy-related skin reactions, such as itching, erythema and wheals, as well as insect bites. However, their action has not been reliably proven yet...
June 27, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28701166/which-early-life-events-or-current-environmental-and-lifestyle-factors-influence-lung-function-in-adolescents-results-from-the-giniplus-lisaplus-studies
#19
Agnes Luzak, Elaine Fuertes, Claudia Flexeder, Marie Standl, Andrea von Berg, Dietrich Berdel, Sibylle Koletzko, Joachim Heinrich, Dennis Nowak, Holger Schulz
BACKGROUND: Various factors may affect lung function at different stages in life. Since investigations that simultaneously consider several factors are rare, we examined the relative importance of early life, current environmental/lifestyle factors and allergic diseases on lung function in 15-year-olds. METHODS: Best subset selection was performed for linear regression models to investigate associations between 21 diverse early life events and current factors with spirometric parameters (forced vital capacity, forced expiratory volume in 1 s and maximal mid-expiratory flow (FEF25-75)) in 1326 participants of the German GINIplus and LISAplus birth cohorts...
July 12, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28698345/suboptimal-vitamin-d-status-in-korean-adolescents-a-nationwide-study-on-its-prevalence-risk-factors-including-cotinine-verified-smoking-status-and-association-with-atopic-dermatitis-and-asthma
#20
Eun Jung Byun, Jinyoung Heo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
OBJECTIVE: To determine the prevalence and risk factors for suboptimal vitamin D status in Korean adolescents and to assess its relationship with atopic dermatitis (AD) and asthma at a national level. DESIGN: This is a cross-sectional study with data from the Korean National Health and Nutrition Examination Survey. Information regarding socioeconomic characteristics, clinical data and environmental factors was collected. Blood and urine samples were taken for vitamin D and cotinine, respectively...
July 10, 2017: BMJ Open
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