keyword
https://read.qxmd.com/read/38530447/association-of-vitamin-d-with-disease-severity-in-infants-with-bronchiolitis
#1
JOURNAL ARTICLE
Jashan Mittal, Nikhil Rajvanshi, Kkomal Suvarna, Prawin Kumar, Jagdish Prasad Goyal
UNLABELLED: Vitamin D's role in immune system regulation and its contribution to host defenses against respiratory infections may have implications for bronchiolitis pathophysiology. This cross-sectional study aimed to determine the association between the clinical severity of bronchiolitis and serum vitamin D levels in infants. Infants aged 1 month to 12 months, diagnosed with bronchiolitis, and healthy controls attending routine immunization were enrolled. Baseline characteristics were recorded, including clinical details, bronchiolitis severity, and course during hospital stay...
March 26, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38492159/environmental-interventions-for-preventing-atopic-diseases
#2
REVIEW
Scott Pfirrman, Ashley Devonshire, Andrew Winslow
PURPOSE OF REVIEW: In this review, we detail the exposome (consisting of environmental factors such as diet, microbial colonization, allergens, pollutants, and stressors), mechanistic and clinical research supporting its influence on atopic disease, and potentiation from climate change. We highlight contemporary environmental interventions and available evidence substantiating their roles in atopic disease prevention, from observational cohorts to randomized controlled trials, when available...
March 16, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38485111/a-critical-review-on-the-long-term-covid-19-impacts-on-patients-with-diabetes
#3
JOURNAL ARTICLE
Sumel Ashique, Neeraj Mishra, Ashish Garg, Sweta Garg, Arshad Farid, Shweta Rai, Gaurav Gupta, Dua Kamal, Keshav Raj Paudel, Farzad Taghizadeh-Hesary
BACKGROUND: The world is currently grappling with the potentially life-threatening coronavirus disease 2019 (COVID-19), marking it as the most severe health crisis in the modern era. COVID-19 has led to a pandemic, with the World Health Organization (WHO) predicting that individuals with diabetes are at a higher risk of contracting the virus compared to the general population. This review aims to provide a practical summary of the long-term impacts of COVID-19 on patients with diabetes...
March 12, 2024: American Journal of Medicine
https://read.qxmd.com/read/38461819/the-influence-of-vitamin-d-on-pregnancy-and-outcomes-current-knowledge-and-future-perspectives
#4
Zhanar Kurmangali, Bibigul Abdykalykova, Aimen Kurmangali, Danat Zhantagulov, Milan Terzic
Vitamin D deficiency increases the risk of adverse pregnancy outcomes. The high prevalence of vitamin D deficiency worldwide requires the analysis of scientific publications to make recommendations for the prevention, management and treatment of vitamin D deficiency in pregnant women. The purpose of the research was to explore the relationship between pathology and pregnancy outcomes with serum 25-hydroxycholecalciferol levels and vitamin D supplementation. A literature search was performed for systematic literature reviews with meta-analyses published between January 2018 and February 2023...
March 8, 2024: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/38459594/circulating-mirnas-associate-with-historical-childhood-asthma-hospitalization-in-different-serum-vitamin-d-groups
#5
JOURNAL ARTICLE
Xiaoning Hong, Mingye Jiang, Alvin T Kho, Anshul Tiwari, Haiyan Guo, Alberta L Wang, Michael J McGeachie, Scott T Weiss, Kelan G Tantisira, Jiang Li
BACKGROUND: Vitamin D may help to alleviate asthma exacerbation because of its anti-inflammation effect, but the evidence is inconsistent in childhood asthma. MiRNAs are important mediators in asthma pathogenesis and also excellent non-invasive biomarkers. We hypothesized that circulating miRNAs are associated with asthma exacerbation and modified by vitamin D levels. METHODS: We sequenced baseline serum miRNAs from 461 participants in the Childhood Asthma Management Program (CAMP)...
March 8, 2024: Respiratory Research
https://read.qxmd.com/read/38447665/the-association-of-milk-and-multiple-food-avoidance-with-growth-parameters-in-infants-and-children
#6
JOURNAL ARTICLE
Cansin Sackesen, Betul Buyuktiryaki, Tugba Gokce, Emre Gogebakan, Beliz Su Gundogdu, Sevgi Bilgic Eltan, Elif Karakoc-Aydiner, Ebru Arik Yilmaz, Ceren Can, Hilal Cengiz, Ozlem Unlugedik, Nevin Celik, Said Incir, Gul Yesiltepe Mutlu, Damla Yildirim, Hulya Gokmen Ozel, Sukru Hatun
BACKGROUND: Recent studies reported that strict avoidance of milk products in cow's milk allergy (CMA) impacts growth and bone turnover, causing negative calcium balance and changes in bone metabolism. OBJECTIVE: To investigate biochemical parameters to predict bone turnover and its relations with height and weight measurements and nutritional intake. METHODS: Height, weight, and body mass index (BMI) z scores were plotted for age according to the World Health Organization...
March 4, 2024: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/38423800/non-pharmacological-interventions-for-asthma-prevention-and-management-across-the-life-course-umbrella-review
#7
REVIEW
Xunliang Tong, Xinyue Zhang, Mengyuan Wang, Zijun Wang, Fawu Dong, Enying Gong, Torsten Zuberbier, Yanming Li
BACKGROUND: The impact of non-pharmacological interventions (NPIs) on asthma prevention and management is insufficiently examined. We aim to comprehensively evaluate and synthesize existing evidence regarding the effectiveness of various NPIs throughout the life course. METHODS: We conducted a systematic search and screening of reviews that examined the effectiveness of various NPIs on asthma prevention and control in the Cochrane Library, PubMed, Embase, and Ovid databases...
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38417857/oral-administration-of-apple-pectin-solution-improves-atopic-dermatitis-in-a-mouse-model
#8
JOURNAL ARTICLE
Asuka Fujisaki, Aya Matsui, Kosuke Shiki, Rika Tateishi, Tatsuki Itoh
The development of atopic dermatitis (AD) involves multiple factors. Three such factors are particularly important in AD onset: immune abnormalities, skin barrier dysfunction, and itching. Many studies report that an imbalance between helper T (Th)1 and Th2 cells causes AD. Apple pectin, a prebiotic, has preventative effects in other allergic diseases (e.g., bronchial asthma and AD), but its potential benefits in AD are unclear. In this study, we investigated the effect of oral apple pectin administration on skin inflammation in an AD mouse model and examined changes in T cells involved in AD...
2024: Journal of Nutritional Science and Vitaminology
https://read.qxmd.com/read/38415448/mini-review-on-vitamin-d-in-pediatric-population-and-its-role-in-respiratory-and-atopic-disorders
#9
JOURNAL ARTICLE
Cristiana Indolfi, Angela Klain, Giulio Dinardo, Fabio Decimo, Maria Maddalena Marrapodi, Amelia Licari, Michele Miraglia Del Giudice
In recent years, our comprehension of the function of vitamin D has significantly evolved. The ubiquitous presence of the vitamin D receptor (Vitamin D Receptor- VDR) in the body has led to its redefinition from a steroidal hormone primarily involved in skeletal functions to a hormone with pleiotropic effects, exerting its influence on the circulatory, nervous, and immune systems. This has prompted investigations into its potential use in preventing and treating chronic metabolic disorders, cardiovascular diseases, infections, and allergic and autoimmune diseases...
February 20, 2024: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/38397449/the-association-of-vitamin-d-receptor-gene-polymorphisms-with-vitamin-d-total-ige-and-blood-eosinophils-in-patients-with-atopy
#10
JOURNAL ARTICLE
Daina Bastyte, Laura Tamasauskiene, Ieva Stakaitiene, Rasa Ugenskiene, Brigita Gradauskiene Sitkauskiene
BACKGROUND: In order to improve the control of atopic diseases, it is important to clarify the pathogenesis of atopy and identify its various triggers. Single nucleotide polymorphisms (SNPs) of the vitamin D receptor gene ( VDR ) may impact atopy. The aim of this study was to investigate the possible associations between VDR SNPs and vitamin D, total IgE, and eosinophils in atopy. METHODS: In total, 203 adults, including 122 patients with atopic diseases (45 with atopic dermatitis, 77 with allergic asthma) and 81 healthy controls, were involved in the study...
February 11, 2024: Biomolecules
https://read.qxmd.com/read/38397331/vitamin-d-level-and-immune-modulation-in-children-with-recurrent-wheezing
#11
JOURNAL ARTICLE
Gavriela Feketea, Emilia Vassilopoulou, Oana Andreescu, Elena Camelia Berghea, Raluca Maria Pop, Octavia Sabin, Mihnea Zdrenghea, Ioana Corina Bocsan
INTRODUCTION AND AIM: A direct causal relationship between vitamin D (vit D) deficiency and recurrent wheezing has not been proven. The present study investigated the role of vit D in enhancing the risk of asthma or recurrent wheezing by modifying the intensity of the inflammatory process. MATERIAL AND METHOD: Forty children with wheezing presenting at the emergency service and sixteen healthy control subjects were included in the study. Children with wheezing were either in the first episode (20) or with recurrent wheezing (20)...
February 8, 2024: Children
https://read.qxmd.com/read/38360214/vitamin-d-primary-prevention-of-respiratory-infections-and-asthma-in-early-childhood-evidence-and-mechanisms
#12
JOURNAL ARTICLE
Nicklas Brustad, Bo Chawes
Respiratory infections are a leading cause of child morbidity worldwide and asthma is the most common chronic disorder in childhood. Both conditions associate with high socioeconomic costs and are major reasons for medication prescriptions and hospitalizations in children. Vitamin D deficiency has concomitantly increased with asthma prevalence and is hypothesized to play a key role in the development. Current evidence suggests that high prenatal and early childhood vitamin D could be protective against respiratory infections and asthma in some studies where several mechanisms are proposed...
February 13, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38344540/vitamin-d-deficiency-in-children-and-adolescents-in-saudi-arabia-a-systematic-review
#13
REVIEW
Meath S Alhamed, Fahad Alharbi, Abdullatif Al Joher, Sara Dhahry, Albandari A Fallatah, Omar H Alanazi, Jawaher M Almutiri, Saida S Albaradie, Budoor Aziz A Al Enezi, Mashail S Albishi
Vitamin D deficiency is a globally recognized health concern, with particular prominence in specific geographies and demographics. Saudi Arabia, with its unique climatic conditions and cultural practices, has been under scrutiny regarding the prevalence of this deficiency, especially among children and adolescents. This systematic review aimed to assess the prevalence of vitamin D deficiency among children and adolescents in Saudi Arabia by compiling and analyzing various studies to offer a comprehensive view of the situation...
January 2024: Curēus
https://read.qxmd.com/read/38339221/genetic-diversity-in-bronchial-asthma-susceptibility-exploring-the-role-of-vitamin-d-receptor-gene-polymorphisms-in-varied-geographic-contexts
#14
JOURNAL ARTICLE
Natalia Paramonova, Ilva Trapina, Brigita Gradauskiene Sitkauskiene, Samanta Plavina, Laura Tamasauskiene, Daina Bastyte, Ingrida Rumba-Rozenfelde, Sandra Tapina, Ieva Stakaitiene, Rasa Ugenskiene, Lawrence Shih-Hsin Wu, Jiu-Yao Wang, Miao-Hsi Hsieh, Pei-Chi Chen, Nikolajs Sjakste
Bronchial asthma (BA) exhibits varying prevalence across global populations, prompting a comprehensive investigation into genetic and environmental determinants. Vitamin D is a potent immunomodulator capable of suppressing inflammatory signals in several cell types involved in the asthmatic response; it exerts effects on the immune system by binding to the nuclear vitamin D receptor (VDR). VDR gene genetic variations are affecting serum vitamin D levels with a possible role in the BA risk. The current study aimed to examine the complex interaction of various factors (genetic background, serum vitamin D levels, and geographic location) to identify differences in the influence of these factors on the susceptibility to asthma between populations at different latitudes...
February 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38337625/the-roles-of-micrornas-in-asthma-and-emerging-insights-into-the-effects-of-vitamin-d-3-supplementation
#15
REVIEW
Adrián Hernández-Díazcouder, Rodrigo Romero-Nava, Blanca E Del-Río-Navarro, Fausto Sánchez-Muñoz, Carlos A Guzmán-Martín, Nayely Reyes-Noriega, Octavio Rodríguez-Cortés, José J Leija-Martínez, Juan Manuel Vélez-Reséndiz, Santiago Villafaña, Enrique Hong, Fengyang Huang
Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway remodeling. Current epidemiological studies reported that hypovitaminosis D is frequent in patients with asthma and is associated with worsening the disease and that supplementation with vitamin D3 improves asthma symptoms. However, despite several advances in the field, the molecular mechanisms of asthma have yet to be comprehensively understood...
January 24, 2024: Nutrients
https://read.qxmd.com/read/38316183/ockham-s-razor-the-application-of-parsimonious-medicine-in-allergy-immunology
#16
JOURNAL ARTICLE
John O Warner
The spectacular advances of modern medicine have distracted clinicians from applying the age-old principles of thorough history and examination followed by only ordering tests relevant to the patient's presentation. The most obvious diagnosis is the most likely and should be addressed first. Ockham's razor, or parsimonious medicine, should be applied because plurality of diagnoses is less likely than a single explanation. Component resolved diagnostics and highly effective biological therapies for allergy/immune mediated diseases have been highly effective when used by specialist allergy services...
February 3, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38297283/multivitamin-consumption-and-childhood-asthma-a-cross-sectional-study-of-the-nhanes-database
#17
JOURNAL ARTICLE
Li Zhang, Yali Xu, Xuemei Li, Fan Yang, Chengxiu Wang, Chunmei Yu
BACKGROUND: Dietary intakes of vitamins are associated with asthma. However, previous studies mainly explored the association between a single vitamin intake and asthma, which did not take the multivitamins into consideration. Herein, this study aims to explore the overall effect of dietary multivitamins consumption on childhood asthma. METHODS: Data of children and adolescents (aged 2-17 years old) were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2015-2018 in this cross-sectional study...
January 31, 2024: BMC Pediatrics
https://read.qxmd.com/read/38287280/analysis-of-the-correlation-between-serum-klotho-and-feno-a-cross-sectional-study-from-nhanes-2007-2012
#18
JOURNAL ARTICLE
Haiyan Mao, Zhenye Xie, Shanshan Huang, Xingkai Shen, Shaofeng Jin, Tong Lin, Zhouxin Yang
BACKGROUND: Klotho is an anti-aging protein that has multiple functions and may play a key role in the pathogenesis and progression of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). Fractional Exhaled Nitric Oxide (FeNO) is a non-invasive and novel biomarker that has the advantages of being simple, fast and reproducible. It can effectively assess the degree of airway inflammation in diseases such as asthma and COPD. Despite these insights, the relationship between serum Klotho levels and FeNO has not been explored yet...
January 29, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38273268/unveiling-the-potent-effect-of-vitamin-d-harnessing-nrf2-ho-1-signaling-pathways-as-molecular-targets-to-alleviate-urban-particulate-matter-induced-asthma-inflammation
#19
JOURNAL ARTICLE
Dandan Ge, Qihong Chen, Xiaohua Xie, Qiyuan Li, Yungang Yang
BACKGROUND: Asthma is the most common allergic disease characterized by an inflammatory response in the airways. Mechanismly, urban particulate matter (PM) is the most widely air pollutant associated with increased asthma morbidity and airway inflammation. Current research found that vitamin D is an essential vitamin with anti-inflammatory, antioxidant and other medical efficacy. Inadequate or deficient vitamin D often leads to the pathogenesis and stability of asthma. NGF exacerbates airway inflammation in asthma by promoting smooth muscle cell proliferation and inducing the Th2 immune response...
January 25, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38256371/the-effects-of-environmental-exposure-on-epigenetic-modifications-in-allergic-diseases
#20
REVIEW
Sandra Mijač, Ivana Banić, Ana-Marija Genc, Marcel Lipej, Mirjana Turkalj
Allergic diseases are one of the most common chronic conditions and their prevalence is on the rise. Environmental exposure, primarily prenatal and early life influences, affect the risk for the development and specific phenotypes of allergic diseases via epigenetic mechanisms. Exposure to pollutants, microorganisms and parasites, tobacco smoke and certain aspects of diet are known to drive epigenetic changes that are essential for immune regulation (e.g., the shift toward T helper 2-Th2 cell polarization and decrease in regulatory T-cell (Treg) differentiation)...
January 7, 2024: Medicina
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