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Intra articular injection

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https://www.readbyqxmd.com/read/27909672/arthroscopic-360%C3%A2-capsular-release-for-adhesive-capsulitis-in-the-lateral-decubitus-position
#1
Gregory L Cvetanovich, Timothy Leroux, Jason T Hamamoto, John D Higgins, Anthony A Romeo, Nikhil N Verma
Idiopathic adhesive capsulitis of the shoulder is a relatively common condition that results in pain and loss of motion due to capsular thickening and fibrosis. Most cases are successfully treated with conservative management including physical therapy and intra-articular steroid injections. If conservative management fails, arthroscopic capsular release allows precise release of thickened capsular tissue with a lower risk of complications and less soft-tissue trauma than manipulation under anesthesia alone...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27906940/a-new-technique-for-the-treatment-of-lumbar-facet-joint-syndrome-using-intra-articular-injection-with-autologous-platelet-rich-plasma
#2
Jiuping Wu, Zhenwu Du, Yang Lv, Jun Zhang, Wei Xiong, Ruiqiang Wang, Rui Liu, Guizhen Zhang, Qinyi Liu
BACKGROUND AND OBJECTIVES: Lumbar facet joint syndrome is currently suggested to be a main source of axial low back pain, and a large portion of axial low back pain is caused by disorders in lumbar facet joints. Intra-articular injection is one of the most common treatment methods in the early clinical application. Therefore, we attempt to seek a new injectable material, autologous platelet rich plasma (PRP), to treat lumbar facet syndrome, as well as to assess its therapeutic effectiveness and safety...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27900853/an-injectable-click-cross-linked-small-intestinal-submucosa-drug-depot-for-the-treatment-of-rheumatoid-arthritis
#3
Kyungsook Kim, Ji Hoon Park, Seung Hun Park, Hye Yun Lee, Jae Ho Kim, Moon Suk Kim
Here, a click-cross-linked small intestine submucosa (SIS) drug depot is described for the treatment of rheumatoid arthritis (RA). To the best of the knowledge, there have been no studies related to the intra-articular injection of methotrexate (Met)-loaded click-cross-linkable SIS (Met-loaded Cx-SIS) for RA treatment. As the key objective of this work, injectable formulations of tetrazine-modified SIS (TE-SIS) and transcyclooctene-modified SIS (TC-SIS) are employed as drug depots. Within a few seconds, the simple mixing of equal amounts of TE-SIS and TC-SIS suspensions forms a gelatinous click-cross-linked SIS (Cx-SIS) drug depot in vitro and in vivo...
November 30, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27900293/combined-use-of-platelet-rich-plasma-micro-fat-in-sport-and-race-horses-with-degenerative-joint-disease-preliminary-clinical-study-in-eight-horses
#4
Fabrizio Bembo, Julia Eraud, Cecile Philandrianos, Baptiste Bertrand, Alain Silvestre, Julie Veran, Florence Sabatier, Guy Magalon, Jeremy Magalon
BACKGROUND: To assess the safety and potential efficacy of a standardized technique consisting of intra-articular injection of 10 cc of a homogeneous mixed product using autologous micro-fat and platelet rich plasma (PRP) (ratio 1:1) in the carpus or the fetlock joint of sport horses presenting degenerative joint disease (DJD). METHODS: Eight sport horses with DJD confirmed by radiography and ultrasonography and causing lameness and the impossibility to compete were treated...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27895468/increased-localized-delivery-of-piroxicam-by-cationic-nanoparticles-after-intra-articular-injection
#5
Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang
Piroxicam (PRX), a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP) was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after intra-articular (IA) injection, by forming micrometer-sized electrostatic clusters with endogenous hyaluronic acid (HA) in the synovial cavity...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27895439/comparison-of-two-different-molecular-weight-intra-articular-injections-of-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#6
I Gigis, E Fotiadis, A Nenopoulos, K Tsitas, I Hatzokos
BACKGROUND: Knee osteoarthritis (OA) is an incurable joint disorder, representing a major public health issue. Among options for symptom control, viscosupplementation with hyaluronic acid (HA) had established usefulness in pain and function improvement of the knee. However, it is not clear which form of HA yields better results. MATERIAL AND METHODS: We compared two HA preparations with high (HMW) or low molecular weight (LMW) in terms of pain control and function improvement using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the visual analog scale (VAS) score in patients with knee OA...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27891055/imaging-guidance-improves-the-results-of-viscosupplementation-with-hanox-m-xl-in-patients-with-ankle-osteoarthritis-results-of-a-clinical-survey-in-50-patients-treated-in-daily-practice
#7
Marie Bossert, Daniel Boublil, Jean-Marc Parisaux, Ana-Maria Bozgan, Emmanuel Richelme, Thierry Conrozier
BACKGROUND: The objective of this survey was to assess retrospectively the interest of performing viscosupplementation using imaging guidance in patients suffering from ankle osteoarthritis (OA). PATIENTS AND METHODS: This is a multicenter retrospective survey using a standardized questionnaire. Fifty patients suffering from ankle OA and treated, in daily clinical practice, with a single intra-articular injection of a novel viscosupplement made of a combination of a non-animal cross-linked hyaluronan and mannitol, HANOX M-XL, were included in the survey...
2016: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27891035/intradiscal-and-intra-articular-facet-infiltrations-with-plasma-rich-in-growth-factors-reduce-pain-in-patients-with-chronic-low-back-pain
#8
Fernando Kirchner, Eduardo Anitua
CONTEXT: Low back pain (LBP) is a complex and disabling condition, and its treatment becomes a challenge. AIMS: The aim of our study was to assess the clinical outcome of plasma rich in growth factors (PRGF-Endoret) infiltrations (one intradiscal, one intra-articular facet, and one transforaminal epidural injection) under fluoroscopic guidance-control in patients with chronic LBP. PRGF-Endoret which has been shown to be an efficient treatment to reduce joint pain...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27881922/effectiveness-of-etofenamate-for-treatment-of-knee-osteoarthritis-a-randomized-controlled-trial
#9
Savaş Güner, Mehmet Ata Gökalp, Abdurrahim Gözen, Seyyid Şerif Ünsal, Şükriye İlkay Güner
The intramuscular application of etofenamate in the treatment of knee osteoarthritis was not observed in the existing English language literature. The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis. The patients were randomly divided into etofenamate (n=29) and HA (n=30) groups. Intramuscular etofenamate injection was administered as a series of seven intramuscular injections at intervals of 1 day...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27875757/the-effect-of-body-mass-index-on-fluoroscopy-time-and-radiation-dose-in-intra-articular-glenohumeral-joint-injections
#10
Ryan Mattie, Zachary L McCormick, Benjamin Fogg, Daniel M Cushman
PURPOSE: To determine the relationship between body mass index (BMI) and fluoroscopy time and radiation dose during fluoroscopy-guided glenohumeral joint injections. METHODS: This was a retrospective analysis of prospectively collected data. Physicians with board certification in Physical Medicine and Rehabilitation and/or Sports Medicine performed or supervised all injections. BMI was calculated within three months of the injection. Fluoroscopy time and radiation dose data were recorded by the fluoroscopy system and transcribed into the clinical database after each procedure...
November 16, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27868141/erythematous-grouped-papules-and-plaque-on-an-intra-articular-injection-area-a-quiz
#11
Young Min Cho, Joong Sun Lee, Dae Won Koo, Kyung Eun Jung
is missing (Quiz).
November 21, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27851984/intra-articular-therapy-with-recombinant-human-gdf5-arrests-disease-progression-and-stimulates-cartilage-repair-in-the-rat-medial-meniscus-transection-mmt-model-of-osteoarthritis
#12
W R Parrish, B A Byers, D Su, J Geesin, U Herzberg, S Wadsworth, A Bendele, B Story
OBJECTIVE: Investigation of osteoarthritis (OA) risk alleles suggests that reduced levels of growth and differentiation factor-5 (GDF5) may be a precipitating factor in OA. We hypothesized that intra-articular recombinant human GDF5 (rhGDF5) supplementation to the OA joint may alter disease progression. METHODS: A rat medial meniscus transection (MMT) joint instability OA model was used. Animals received either one intra-articular injection, or two or three bi-weekly intra-articular injections of either 30 μg or 100 μg of rhGDF5 beginning on day 21 post surgery after structural pathology had been established...
November 13, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27847713/effect-of-intra-articular-hyaluronic-acid-injection-on-hemiplegic-shoulder-pain-after-stroke
#13
Myung Hun Jang, Chang-Hyung Lee, Yong-Il Shin, Soo-Yeon Kim, Sung Chul Huh
OBJECTIVE: To evaluate the efficacy of intra-articular hyaluronic acid (IAHA) injection for hemiplegic shoulder pain (HSP) after stroke. METHODS: Thirty-one patients with HSP and limited range of motion (ROM) without spasticity of upper extremity were recruited. All subjects were randomly allocated to group A (n=15) for three weekly IAHA injection or group B (n=16) for a single intra-articular steroid (IAS) injection. All injections were administered by an expert physician until the 8th week using a posterior ultrasonography-guided approach...
October 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27847523/intra-articular-hyaluronic-acid-compared-to-traditional-conservative-treatment-in-dogs-with-osteoarthritis-associated-with-hip-dysplasia
#14
Gabriel O L Carapeba, Poliana Cavaleti, Gabriel M Nicácio, Rejane B Brinholi, Rogério Giuffrida, Renata N Cassu
The purpose of this study was to compare the efficacy of the intra-articular (IA) hyaluronic acid injection to traditional conservative treatment (TCT) in dogs with osteoarthritis (OA) induced by hip dysplasia. Sixteen dogs were distributed into two groups: Hyal: IA injection of hyaluronic acid (5-10 mg), and Control: IA injection with saline solution (0.5-1.0 mL) in combination with a TCT using an oral nutraceutical (750-1000 mg every 12 h for 90 days) and carprofen (2.2 mg/kg every 12 h for 15 days)...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27845030/capsule-preserving-hydrodilatation-with-corticosteroid-versus-corticosteroid-injection-alone-in-refractory-adhesive-capsulitis-of-shoulder-a-randomized-controlled-trial
#15
Doo-Hyung Lee, Seung-Hyun Yoon, Michael Young Lee, Kyu-Sung Kwack, Ueon Woo Rah
OBJECTIVE: To determine whether capsule-preserved hydrodilatation with corticosteroid (CPHC) improves pain and function in patients with refractory adhesive capsulitis (AC) better than intra-articular corticosteroid injection (IACI) alone. DESIGN: Prospective randomized controlled study. SETTING: University-affiliated tertiary care hospital. PARTICIPANTS: Primary AC subjects (N=64) with shoulder pain level of visual analogue scale (VAS) ≥ 5 even after the initial administration of IACI alone...
November 11, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27844404/erratum-to-intra-articular-injection-of-urinary-bladder-matrix-reduces-osteoarthritis-development
#16
Heather N Jacobs, Sona Rathod, Matthew T Wolf, Jennifer H Elisseeff
No abstract text is available yet for this article.
November 14, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27842839/thermo-sensitive-injectable-hydrogel-based-on-the-physical-mixing-of-hyaluronic-acid-and-pluronic-f-127-for-sustained-nsaid-delivery
#17
Young-Seok Jung, Wooram Park, Hyejin Park, Deok-Keun Lee, Kun Na
The aim of this research is the development of a new type of intra-articularly injectable thermo-sensitive hydrogels for the long-term delivery of Piroxicam (PX). The thermo-sensitive hydrogel was prepared by the simple physical mixing of HA and Pluronic F-127 (HP) in aqueous solution. The addition of high-molecular-weight HA not only enhanced the mechanical strength of the hydrogel but also elicited a sustained drug release. This result could be attributed to the high-molecular-weight HA-assisted inter-micellar packing in the hydrogel inner structure...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27836707/celecoxib-loaded-pea-microspheres-as-an-auto-regulatory-drug-delivery-system-after-intra-articular-injection
#18
Maarten Janssen, Ufuk Tan Timur, Nina Woike, Tim J M Welting, Guy Draaisma, Marion Gijbels, Lodewijk W van Rhijn, George Mihov, Jens Thies, Pieter J Emans
In this study, we investigated the potential of celecoxib-loaded polyester amide (PEA) microspheres as an auto-regulating drug delivery system for the treatment of pain associated with knee osteoarthritis (OA). Celecoxib release from PEA microspheres and inflammation responsive release of a small molecule from PEA was investigated in vitro. Inflammation responsive release of a small molecule from PEA was observed when PEA was exposed to cell lysates obtained from a neutrophil-like Hl-60 cell line. Following a short initial burst release of ~15% of the total drug load in the first days, celecoxib was slowly released throughout a period of >80days...
November 8, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27836674/chondroprotective-activity-of-n-acetyl-phenylalanine-glucosamine-derivative-on-knee-joint-structure-and-inflammation-in-a-murine-model-of-osteoarthritis
#19
F Veronesi, G Giavaresi, M Maglio, A Scotto d'Abusco, L Politi, R Scandurra, E Olivotto, B Grigolo, R M Borzì, M Fini
OBJECTIVE: Osteoarthritis (OA), the most common chronic degenerative joint disease, is characterized by joint structure changes and inflammation, both mediated by the IκB kinase (IKK) signalosome complex. The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKα kinase activity, has been observed in vitro. The present study aims to further clarify the effect of NAPA in counteracting OA progression, in an in vivo mouse model after destabilization of the medial meniscus (DMM)...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27832815/in-vivo-human-adipose-derived-mesenchymal-stem-cell-tracking-after-intra-articular-delivery-in-a-rat-osteoarthritis-model
#20
Meng Li, Xuan Luo, Xiaoteng Lv, Victor Liu, Guangyu Zhao, Xue Zhang, Wei Cao, Richard Wang, Wen Wang
BACKGROUND: Human adipose-derived mesenchymal stem cells (haMSCs) have shown efficacy in treating osteoarthritis (OA) both preclinically and clinically via intra-articular (IA) injection. However, understanding the mode of action of the cell therapy has been limited by cell tracking capability and correlation between the pharmacokinetics of the injected cells and the intended pharmacodynamics effect. This study aims to explore methodology and to understand in vivo biodistribution of clinical-grade haMSCs labeled with fluorescent dye and injected into an immunocompetent OA rat model...
November 10, 2016: Stem Cell Research & Therapy
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