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Vaccination against HPV

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https://www.readbyqxmd.com/read/27932207/the-current-state-of-therapeutic-and-t-cell-based-vaccines-against-human-papillomaviruses
#1
REVIEW
Andrew Yang, Emily Farmer, John Lin, T-C Wu, Chien-Fu Hung
Human papillomavirus (HPV) is known to be a necessary factor for many gynecologic malignancies and is also associated with a subset of head and neck malignancies. This knowledge has created the opportunity to control these HPV-associated cancers through vaccination. However, despite the availability of prophylactic HPV vaccines, HPV infections remain extremely common worldwide. In addition, while prophylactic HPV vaccines have been effective in preventing infection, they are ineffective at clearing pre-existing HPV infections...
December 5, 2016: Virus Research
https://www.readbyqxmd.com/read/27931989/knowledge-attitudes-and-behaviors-of-the-italian-population-towards-neisseria-meningitidis-streptococcus%C3%A2-pneumoniae-and-hpv-diseases-and-vaccinations-a%C3%A2-cross-sectional-multicentre-study
#2
C de Waure, G Quaranta, C Ianuale, D Panatto, D Amicizia, L Apprato, P Campanella, M Colotto, C De Meo, F Di Nardo, E M Frisicale, D I La Milia, E Rizzitelli, S Aquilani, M P Briata, V Frumento, L Marensi, A Spadea, V Turello, R Gasparini, W Ricciardi
OBJECTIVES: This study addressed knowledge of Streptococcus pneumoniae, Neisseria meningitidis and human papillomavirus (HPV), and attitudes and behaviours towards vaccines against them. STUDY DESIGN: This is a cross-sectional, multicentre study. METHODS: Data were collected through a questionnaire administered to 530 adults who accessed four Departments of Prevention of the Italian National Health Service in 2013. RESULTS: Less than 50% of people gave the right answer to all the questions concerning the three diseases, but 96...
December 2016: Public Health
https://www.readbyqxmd.com/read/27930979/hp91-immunoadjuvant-an-hmgb1-derived-peptide-for-development-of-therapeutic-hpv-vaccines
#3
Somayeh Talebi, Azam Bolhassani, Seyed Mehdi Sadat, Rouhollah Vahabpour, Elnaz Agi, Sepideh Shahbazi
BACKGROUND: High percentage of human cervical malignancy is related to human papillomavirus (HPV) infections. Thus, it is important to find novel non-invasive treatment strategies among various therapeutic HPV vaccines. In current study, we investigated the protective and therapeutic effects of DNA- and protein-based vaccines using HPV16 E7 as a model antigen in tumor mice model. In this line, the full length of high-mobility group box 1 (HMGB1) protein as well as an HMGB1-derived short peptide (Hp91) was used as an adjuvant for stimulating adaptive immunity and developing the potency of these vaccines...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27919863/applying-multiple-data-collection-tools-to-quantify-human-papillomavirus-vaccine-communication-on-twitter
#4
Philip M Massey, Amy Leader, Elad Yom-Tov, Alexandra Budenz, Kara Fisher, Ann C Klassen
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. There are several vaccines that protect against strains of HPV most associated with cervical and other cancers. Thus, HPV vaccination has become an important component of adolescent preventive health care. As media evolves, more information about HPV vaccination is shifting to social media platforms such as Twitter. Health information consumed on social media may be especially influential for segments of society such as younger populations, as well as ethnic and racial minorities...
December 5, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27913692/factors-motivating-hpv-vaccine-uptake-among-vaccinated-and-nonvaccinated-hispanic-young-adult-women
#5
Dionne P Stephens, Hod Tamir, Tami L Thomas
INTRODUCTION: To identify factors influencing human papillomavirus (HPV) vaccination up taking decision making among vaccinated and nonvaccinated Hispanic college women. PARTICIPANTS: Hispanic young women between the ages of 18 and 24 years (N = 49). In total, 26 had not received the HPV vaccine, and 23 had started/completed the vaccine series. METHOD: Participants registered for the study via a psychology research pool at a large public university in the southeast United States after institutional review board approval...
December 2016: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/27910798/a-qualitative-study-of-women-who-experience-side-effects-from-human-papillomavirus-vaccination
#6
Tina Sørensen, Pernille Tanggaard Andersen
INTRODUCTION: In Denmark, vaccination against human papillomavirus (HPV) is offered to girls and women to prevent cervical cancer. Unfortunately, reporting of possible side effects from vaccination has increased in recent years. Therefore, the present study examine women's experiences of side effects from the HPV vaccine. METHODS: In-depth qualitative interviews were conducted with eight HPV-vaccinated Danish women, aged 25-44 years, who experienced side effects from the vaccine...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27902759/seroprevalence-and-associated-factors-of-9-valent-human-papillomavirus-hpv-types-among-men-in-the-multinational-him-study
#7
Shams Rahman, Christine M Pierce Campbell, Dana E Rollison, Wei Wang, Tim Waterboer, Angelika Michel, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Amy R Borenstein, Anna R Giuliano
BACKGROUND: Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Recently a 9-valent HPV (9vHPV) prophylactic vaccine was licensed. Seroprevalence prior to vaccine dissemination is needed for monitoring vaccine effectiveness over time. Few studies have assessed the seroprevalence of 9vHPV types in men. OBJECTIVES: To investigate the seroprevalence of 9vHPV vaccine types and associated risk factors among men residing in Brazil, Mexico, and the United States...
2016: PloS One
https://www.readbyqxmd.com/read/27896666/characteristics-associated-with-hpv-diagnosis-and-perceived-risk-for-cervical-cancer-among-unmarried-sexually-active-college-women
#8
Kelly L Wilson, Clayton J Cowart, Brittany L Rosen, Jairus C Pulczinski, Kayce D Solari, Marcia G Ory, Matthew Lee Smith
Human papillomavirus (HPV) has been identified as the leading cause of cervical cancer. While HPV risk factors have been well studied, less is known about those with HPV and their perceptions about health ramifications. The purposes of this study were to examine unmarried college student women's (1) HPV diagnosis status and (2) perceived risk of getting cervical cancer in the next 5 years. Data were analyzed from 1106 unmarried, sexually active college women aged 18 to 26. Binary logistic regression compared HPV-related knowledge, vaccination-related perceptions, mandate support, healthcare utilization, sexual behaviors, and personal characteristics...
November 28, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27894910/cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus-infection-recommendations-from-a-consensus-conference
#9
Paolo Giorgi Rossi, Francesca Carozzi, Antonio Federici, Guglielmo Ronco, Marco Zappa, Silvia Franceschi
In Italy, the cohorts of women who were offered Human papillomavirus (HPV) vaccination in 2007/08 will reach the age for cervical cancer (CC) screening from 2017. The simultaneous shift from cytology-based screening to HPV test-based screening gives the opportunity for unprecedented reorganisation of CC prevention. The ONS (National Screening Monitoring Centre) Directive and the GISCi (Italian Group for Cervical Screening) identified the consensus conference as the most suitable method for addressing this topic...
November 25, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27893068/immunogenicity-of-the-9-valent-hpv-vaccine-using-2-dose-regimens-in-girls-and-boys-vs-a-3-dose-regimen-in-women
#10
Ole-Erik Iversen, Maria Jose Miranda, Angels Ulied, Terje Soerdal, Erica Lazarus, Kulkanya Chokephaibulkit, Stan L Block, Ales Skrivanek, Abdul Ghani Nur Azurah, Siew Moy Fong, Vladimir Dvorak, Kyung-Hyo Kim, Ramon M Cestero, Matitiahu Berkovitch, Mehmet Ceyhan, Misoo C Ellison, Michael A Ritter, Shuai S Yuan, Mark J DiNubile, Alfred J Saah, Alain Luxembourg
Importance: Human papillomavirus (HPV) infections cause anogenital cancers and warts. The 9-valent HPV vaccine provides protection against 7 high-risk types of HPV responsible for 90% of cervical cancers and 2 other HPV types accounting for 90% of genital warts. Objective: To determine whether HPV type-specific antibody responses would be noninferior among girls and boys aged 9 to 14 years after receiving 2 doses of the 9-valent HPV vaccine compared with adolescent girls and young women aged 16 to 26 years receiving 3 doses...
November 21, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27889616/developments-in-l2-based-human-papillomavirus-hpv-vaccines
#11
REVIEW
Christina Schellenbacher, Richard B S Roden, Reinhard Kirnbauer
Infections with sexually transmitted high-risk Human Papillomavirus (hrHPV), of which there are at least 15 genotypes, are responsible for a tremendous disease burden by causing cervical, and subsets of other ano-genital and oro-pharyngeal carcinomas, together representing 5% of all cancer cases worldwide. HPV subunit vaccines consisting of virus-like particles (VLP) self-assembled from major capsid protein L1 plus adjuvant have been licensed. Prophylactic vaccinations with the 2-valent (HPV16/18), 4-valent (HPV6/11/16/18), or 9-valent (HPV6/11/16/18/31/33/45/52/58) vaccine induce high-titer neutralizing antibodies restricted to the vaccine types that cause up to 90% of cervical carcinomas, a subset of other ano-genital and oro-pharyngeal cancers and 90% of benign ano-genital warts (condylomata)...
November 23, 2016: Virus Research
https://www.readbyqxmd.com/read/27882783/communication-about-sex-and-hpv-among-puerto-rican-mothers-and-daughters
#12
Vivian Colón-López, Natalie Fernández-Espada, Camille Vélez, Velda J Gonzalez, Elba C Diaz-Toro, William A Calo, Lara S Savas, Angela Pattatucci, María E Fernández
OBJECTIVE: Although opportunities to vaccinate against human papillomavirus (HPV) are available, vaccination rates in Puerto Rico remain low. Communication between parents and adolescents about sexual topics may influence decisions about HPV vaccination uptake, particularly among young women; yet, few studies have addressed this issue. This qualitative study explored Puerto Rican mothers' and daughters' communication on sex-related topics, and HPV, including the HPV vaccine. DESIGN: Thirty participants, including 9 mothers and 21 daughters, participated in seven focus groups...
November 24, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27869440/immunology-update-new-vaccines
#13
S Paul Starr
A new 9-valent human papillomavirus (HPV) vaccine is effective against more cancer-causing HPV types than previous vaccines. HPV vaccine series started with previous vaccines can be completed with the 9-valent vaccine. Two new influenza vaccines are available for adults 65 years and older: a high-dose vaccine and an enhanced adjuvant vaccine. These elicit stronger antibody responses than standard-dose vaccines. Current guidelines specify no preference for the new versus standard-dose vaccines. Two new group B meningococcal vaccines are intended for use during outbreaks and for patients with asplenia, complement deficiencies, frequent occupational meningococcus exposure, or for patients who desire protection from type B meningococcus...
November 2016: FP Essentials
https://www.readbyqxmd.com/read/27864489/protecting-women-against-human-papillomavirus-benefits-barriers-and-evidence-based-strategies-to-increase-vaccine-uptake
#14
Tamera Coyne-Beasley, Bridget E Hochwalt
Human papillomavirus (HPV) infection significantly impacts women, as it can cause cancers and precancers of the cervix, vulva, vagina, oropharynx, and anus. However, many of these cancers can be prevented by HPV vaccination. Despite evidence of vaccine effectiveness and safety, vaccination rates remain low. Evidence-based strategies should be utilized to reduce barriers and increase vaccination rates.
November 2016: North Carolina Medical Journal
https://www.readbyqxmd.com/read/27861611/knowledge-awareness-and-attitude-on-hpv-hpv-vaccine-and-cervical-cancer-among-the-college-students-in-india
#15
Shazia Rashid, Satyanarayana Labani, Bhudev C Das
BACKGROUND: Infection of specific high risk Human papillomaviruses (HPVs) is known to cause cervical cancer and two prophylactic vaccines have been developed against two major high risk HPV types 16 and 18 for prevention of cervical cancer. Because of societal, religious and ethical issues associated with the vaccination of adolescent girls in India together with lack of awareness about HPV and HPV vaccines, no successful HPV immunization program has been employed in India. OBJECTIVE: To determine knowledge, awareness and attitude of college students on HPV, HPV vaccine and cervical cancer...
2016: PloS One
https://www.readbyqxmd.com/read/27858157/gender-and-age-specific-seroprevalence-of-human-papillomavirus-16-and-18-in-general-population-in-tehran-iran
#16
Arezoo Aghakhani, Setareh Mamishi, Shahram Sabeti, Farahnaz Bidari-Zerehpoosh, Mohammad Banifazl, Anahita Bavand, Amitis Ramezani
The assessment of the gender and age-specific seroprevalence of human papillomavirus (HPV) is essential for planning of HPV vaccine implementation into the preventive programs. In this study, we aimed to determine the age-specific seroprevalence of HPV-16 and 18 in both males and females in Tehran, Iran. Three hundred and seventy-eight women (10-35 years) and 162 men (10-25 years) from Tehran, Iran, were enrolled. Anti-HPV IgG antibodies against HPV-16 and HPV-18 were detected by ELISA using papillomavirus type 16 and 18 L1-capsids as antigen...
November 17, 2016: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/27843487/invasive-cervical-cancers-in-the-united-states-botswana-and-kenya-hpv-type-distribution-and-health-policy-implications
#17
Aaron Ermel, Brahim Qadadri, Yan Tong, Omenge Orang'o, Benson Macharia, Doreen Ramogola-Masire, Nicola M Zetola, Darron R Brown
BACKGROUND: More deaths occur in African women from invasive cervical cancer (ICC) than from any other malignancy. ICC is caused by infection with oncogenic types of human papillomavirus (HPV). Co-infection with the human immunodeficiency virus (HIV) accelerates the natural history of ICC, and may influence the HPV type distribution. Because HPV vaccines are available, this malignancy is theoretically preventable, but the vaccines are largely type-specific in protection against infection...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27833202/a-physician-s-reflection-on-the-moral-use-of-human-papilloma-virus-vaccine
#18
EDITORIAL
Greg F Burke
Controversies often surround the use of vaccines, particularly among the pediatric population. Often, the possible temporal relationship between vaccination and subsequent disease is at the center of the controversy. However, others have questioned the moral status of the human papilloma virus (HPV) vaccine because of some instances of state coercion and also the possibility that the vaccine may promote promiscuity. This article addresses the moral status of the HPV vaccine from the perspective of a primary care physician and father of four daughters...
August 2016: Linacre Quarterly
https://www.readbyqxmd.com/read/27831602/-evaluation-of-the-cost-effectiveness-of-two-alternative-human-papillomavirus-vaccines-as-prophylaxis-against-uterine-cervical-cancer
#19
Rafael Bolaños-Díaz, Romina A Tejada, Jessica Beltrán, Seimer Escobedo-Palza
Objectives.: To determine the cost-effectiveness of human papillomavirus (HPV) vaccination and cervical lesion screening versus screening alone for the prevention of uterine cervical cancer (UCC). Materials and methods.: This cost-effectiveness evaluation from the perspective of the Ministry of Health employed a Markov model with a 70-year time horizon and three alternatives for UCC prevention (screening alone, screening + bivalent vaccine, and screening + quadrivalent vaccine) in a hypothetical cohort of 10-year-old girls...
July 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27816370/threshold-cost-effectiveness-analysis-for-a-therapeutic-vaccine-against-hpv-16-18-positive-cervical-intraepithelial-neoplasia-in-the-netherlands
#20
Jos Luttjeboer, Didik Setiawan, Qi Cao, Toos Cahh Daemen, Maarten J Postma
In this study, the potential price for a therapeutic vaccine against Human Papilloma Virus (HPV)-16 & 18 (pre)-malignant cervical lesions is examined. A decision tree model was built in the context of the new Dutch cervical cancer-screening program and includes a primary test for the presence of HPV. Based on data of cervical cancer screening and HPV prevalence in the Netherlands, cohorts were created with HPV-16 or 18 positive women with cervical intraepithelial neoplasia (CIN) 2 or 3 or cervical cancer stage 1A (FIGO 1A)...
December 7, 2016: Vaccine
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