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Vaccination against HPV

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https://www.readbyqxmd.com/read/28075249/cost-effectiveness-analysis-of-as04-adjuvanted-human-papillomavirus-16-18-vaccine-compared-with-human-papillomavirus-6-11-16-18-vaccine-in-the-philippines-with-the-new-2-dose-schedule
#1
Maria Julieta Germar, Carrie Purugganan, Ma Socorro Bernardino, Benjamin Cuenca, Y-Chen Chen, Xiao Li, Georges Van Kriekinge, I-Heng Lee
Cervical cancer (CC) is the second leading cause of cancer death among Filipino women. Human papillomavirus (HPV) vaccination protects against CC. Two vaccines (AS04-HPV-16/18 and 4vHPV) are approved in the Philippines; they were originally developed for a 3-dose (3 D) administration and have recently been approved in a 2-dose schedule (2 D). This study aims to evaluate the cost-effectiveness and budget impact of HPV vaccination of 13-year-old Filipino girls, in addition to current screening, in the new 2 D schedule...
January 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28074443/knowledge-behaviors-and-attitudes-about-human-papilloma-virus-among-nursing-students-in-izmir-turkey
#2
Hatice Bal-Yılmaz, Deborah Koniak-Griffin
Human papillomavirus (HPV) is transmitted through sexual contact and can cause cervical cancer. The aim of this study was to determine knowledge, behaviors, and attitudes about human papillomavirus (HPV) in nursing students in a baccalaureate program. This study was conducted with a sample of 624 students. Data were collected via questionnaires administered during the first class time. Students' knowledge about HPV was high; 90.5% knew HPV can cause cervical cancer; 94.6% recognized it as a sexually transmitted disease...
January 10, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28072683/knowledge-of-greek-adolescents-on-human-papilloma-virus-hpv-and-vaccination-a-national-epidemiologic-study
#3
Dennis Vaidakis, Irini Moustaki, Ioannis Zervas, Anastasia Barbouni, Kyriaki Merakou, Maria S Chrysi, George Creatsa, Theodoros Panoskaltsis
The aim of the present study was to identify the sexual behavior, attitudes, beliefs, and knowledge on sexually transmitted infections (STIs) focused on human papilloma virus (HPV) in the Greek adolescent population. The participants were 4547 adolescents, a representative sample for Greek territory with a mean age of 17 years. After written permission from Greek ministry of education each student completed a questionnaire with 36 questions. The fields covered were demographic characteristics, sexual life data, and basic knowledge on HPV...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28056100/chimeric-l2-based-virus-like-particle-vlp-vaccines-targeting-cutaneous-human-papillomaviruses-hpv
#4
Bettina Huber, Christina Schellenbacher, Saeed Shafti-Keramat, Christoph Jindra, Neil Christensen, Reinhard Kirnbauer
Common cutaneous human papillomavirus (HPV) types induce skin warts, whereas species beta HPV are implicated, together with UV-radiation, in the development of non-melanoma skin cancer (NMSC) in immunosuppressed patients. Licensed HPV vaccines contain virus-like particles (VLP) self-assembled from L1 major capsid proteins that provide type-restricted protection against mucosal HPV infections causing cervical and other ano-genital and oro-pharyngeal carcinomas and warts (condylomas), but do not target heterologous HPV...
2017: PloS One
https://www.readbyqxmd.com/read/28053902/human-papilloma-virus-in-oral-cancer
#5
REVIEW
Soung Min Kim
Cervical cancer is the second most prevalent cancer among women, and it arises from cells that originate in the cervix uteri. Among several causes of cervical malignancies, infection with some types of human papilloma virus (HPV) is well known to be the greatest cervical cancer risk factor. Over 150 subtypes of HPV have been identified; more than 40 types of HPVs are typically transmitted through sexual contact and infect the anogenital region and oral cavity. The recently introduced vaccine for HPV infection is effective against certain subtypes of HPV that are associated with cervical cancer, genital warts, and some less common cancers, including oropharyngeal cancer...
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28053505/spotlight-on-the-9-valent-hpv-vaccine
#6
REVIEW
Pier Luigi Lopalco
Starting in 2006, vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries. Two vaccines have been successfully used, a bivalent vaccine targeting HPV-related cancers (bHPV) and a quadrivalent vaccine (qHPV) targeting both HPV-related cancers and genital warts. Between December 2014 and June 2015, a new nonavalent HPV vaccine (9vHPV) was granted marketing authorization in the USA and Europe. The 9vHPV was developed from the qHPV and includes five additional HPV types that should increase the level of protection toward HPV-related cancers...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28038948/-immunisation-schedule-of-the-spanish-association-of-paediatrics-2017-recommendations
#7
David Moreno-Pérez, Francisco José Álvarez García, Javier Arístegui Fernández, María José Cilleruelo Ortega, José María Corretger Rauet, Nuria García Sánchez, Ángel Hernández Merino, Teresa Hernández-Sampelayo Matos, Manuel Merino Moína, Luis Ortigosa Del Castillo, Jesús Ruiz-Contreras
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics (CAV- AEP) annually publishes the immunisation schedule which, in our opinion, is considered optimal for children resident in Spain, taking into account the evidence available on current vaccines. Pneumococcal and varicella immunisation in early childhood is already included in all funded vaccines present in the regional immunisation programmes. Furthermore, this committee establishes recommendations on vaccines not included in official calendars (non-funded immunisations), such as rotavirus, meningococcal B, and meningococcal ACWY...
December 27, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28034886/sustained-antibody-responses-six-years-following-one-two-or-three-doses-of-quadrivalent-hpv-vaccine-in-adolescent-fijian-girls-and-subsequent-responses-to-a-single-dose-of-bivalent-hpv-vaccine-a-prospective-cohort-study
#8
Zheng Quan Toh, Fiona M Russell, Rita Reyburn, James Fong, Evelyn Tuivaga, Tupou Ratu, Cattram D Nguyen, Rachel Devi, Mike Kama, Silivia Matanitobua, Sepehr N Tabrizi, Suzanne M Garland, Rohit Sinha, Ian Frazer, Lisi Tikoduadua, Joseph Kado, Eric Rafai, Edward K Mulholland, Paul V Licciardi
BACKGROUND: The antibody response following reduced HPV vaccine doses has not been determined. We compared the antibody responses in girls previously vaccinated with zero, one, two or three doses of 4vHPV (Gardasil(®),Merck Inc.) six years previously. METHODS: A prospective cohort study was undertaken in 200 Fijian girls (15-19 years old). Approximately equal numbers of girls from two main ethnic groups (Fijians-of-Indian-Descent;FIDs) and (Indigenous-Fijians;iTaukei) in Fiji were recruited for each dosage groups...
December 28, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28034371/vaccines-against-human-papillomavirus-infections-protection-against-cancer-genital-warts-or-both
#9
REVIEW
E A Joura, S Pils
Since 2006, three vaccines against infections and disease caused by human papillomavirus (HPV) became available in Europe-in 2006 a quadrivalent HPV 6/11/16/18 vaccine, in 2007 a bivalent HPV 16/18 vaccine and in 2015 a nonavalent HPV 6/11/16/18/31/33/45/52/58 vaccine. HPV 16 and 18 are the most oncogenic HPV strains, causing about 70% of cervical and other HPV-related cancers, HPV 6 and 11 cause 85% of all genital warts. The additional types of the polyvalent vaccine account for about 20% of invasive cervical cancer and >35% of pre-cancer...
December 1, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28011916/immune-responses-after-two-versus-three-doses-of-hpv-vaccination-up-to-4%C3%A2-years-post-vaccination-an-observational-study-among-dutch-routinely-vaccinated-girls-hpv2d
#10
Robine Donken, Tessa M Schurink-van 't Klooster, Rutger M Schepp, Fiona R M van der Klis, Mirjam J Knol, Chris J L M Meijer, Hester E de Melker
BACKGROUND: In 2014 the Netherlands switched from three- to two-doses for routine vaccination with the prophylactic bivalent human papillomavirus (HPV)-vaccine. This study explored whether antibody responses are non-inferior after two- compared to three-doses in girls. METHODS: Girls vaccinated at twelve years of age with two-(0,6 months) or three-doses (0,1,6 months) of the bivalent HPV vaccine were identified in the vaccination registration system. Type-specific antibody concentrations and avidity against HPV16/18/31/33/45/52/58 were assessed...
December 23, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28011911/effectiveness-of-hpv-vaccination-on-prevalence-of-vaccine-genotypes-in-young-sexually-active-women-in-france
#11
Isabelle Heard, Laura Tondeur, Laurence Arowas, Marie Demazoin, Michaël Falguières, Isabelle Parent Du Chatelet
BACKGROUND: Effectiveness of human papillomavirus (HPV) vaccines in the context of both guidelines which recommend vaccination at 14 years and modest vaccine coverage is poorly documented. METHOD: Residual specimens from females aged under 25 years undergoing chlamydia testing were collected, together with demographic, sexual behaviour and vaccine status data. HPV genotypes were determined using the PapilloCheck® test system. We compared vaccine type (VT, types 6,11,16,18) prevalence according to vaccination status and identified factors associated with VT prevalence...
December 23, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28004837/the-de-and-fg-loops-of-the-hpv-major-capsid-protein-contribute-to-the-epitopes-of-vaccine-induced-cross-neutralising-antibodies
#12
Sara L Bissett, Anna Godi, Simon Beddows
The human papillomavirus (HPV) vaccines consist of major capsid protein (L1) virus-like particles (VLP) and are highly efficacious against the development of cervical cancer precursors attributable to oncogenic genotypes, HPV16 and HPV18. A degree of vaccine-induced cross-protection has also been demonstrated against genetically-related genotypes in the Alpha-7 (HPV18-like) and Alpha-9 (HPV16-like) species groups which is coincident with the detection of L1 cross-neutralising antibodies. In this study the L1 domains recognised by inter-genotype cross-neutralising antibodies were delineated...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28004510/mothers-intentions-to-vaccinate-their-teenaged-children-against-human-papillomavirus-as-predicted-by-sex-in-south-korea-an-application-of-the-theory-of-planned-behavior
#13
Kyung Mi Kim, Jeong Sil Choi
AIM: This study was conducted in order to examine the intention of mothers to vaccinate their teenaged children against human papillomavirus (HPV) infection, according to the children's sex. Based on the theory of planned behavior, the study identified the sex-specific predictors of mothers' intention to vaccinate their teenaged children against HPV. METHODS: This was a descriptive survey study that included, as participants, 200 mothers whose teenaged children were not vaccinated against HPV...
December 22, 2016: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28000571/immuno-stimulating-peptide-derived-from-hmgb1-is-more-effective-than-the-n-terminal-domain-of-gp96-as-an-endogenous-adjuvant-for-improvement-of-protein-vaccines
#14
Somayeh Talebi, Azam Bolhassani, Talat Mokhtari Azad, Arash Arashkia, Mohammad Hossein Modaresi
Up to now, different protein vaccine modalities against human papillomavirus (HPV) have been designed to control cervical cancer. The important issue is to increase their immunogenicity using appropriate adjuvants. Among heat shock proteins (HSPs), glycoprotein 96 (Gp96) and its N-terminal region (NT-gp96) have attracted a specific interest in stimulation of antigen-specific immune responses in vivo. Furthermore, the potency of high mobility group box 1 (HMGB1) protein and its fragment (Hp91) was reported to enhance the desired immune responses against various disorders...
December 20, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27998015/efficacy-immunogenicity-and-safety-of-the-hpv-16-18-as04-adjuvanted-vaccine-in-chinese-women-aged-18-25%C3%A2-years-event-triggered-analysis-of-a-randomized-controlled-trial
#15
Feng-Cai Zhu, Shang-Ying Hu, Ying Hong, Yue-Mei Hu, Xun Zhang, Yi-Ju Zhang, Qin-Jing Pan, Wen-Hua Zhang, Fang-Hui Zhao, Cheng-Fu Zhang, Xiaoping Yang, Jia-Xi Yu, Jiahong Zhu, Yejiang Zhu, Feng Chen, Qian Zhang, Hong Wang, Changrong Wang, Jun Bi, Shiyin Xue, Lingling Shen, Yan-Shu Zhang, Yunkun He, Haiwen Tang, Naveen Karkada, Pemmaraju Suryakiran, Dan Bi, Frank Struyf
We previously reported the results of a phase II/III, double-blind, randomized controlled study in Chinese women (NCT00779766) showing a 94.2% (95% confidence interval: 62.7-99.9) HPV-16/18 AS04-adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6-month (M) persistent infection (PI) with a mean follow-up of <2 years, and immunogenicity until 7 months post-dose 1. Here, we report efficacy and safety results from an event-triggered analysis with ~3 years longer follow-up, and immunogenicity until M24...
December 20, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27993116/molecular-approaches-target-to-immunotherapy-for-hpv-associated-cancers
#16
Fang Zhou, Lifang Zhang, Kong-Nan Zhao
Infection with human papillomavirus (HPVs) causes many cancers, which account for about 10-20% of total human cancers. Two recently developed prophylactic vaccines against virus infection confer strong immunogenicity to provide long-term protection. The use of these vaccines has contributed to a substantial decrease in the rates of cervical cancer the second most common cancer of women worldwide. However, therapeutic vaccines that can eliminate pre-existing HPV infections and treat an existing HPV- caused cancer have not been developed...
December 15, 2016: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/27986194/cost-effectiveness-study-of-hpv-vaccination-as-a-primary-prevention-strategy-for-anal-cancer-in-hiv-positive-men-in-chile
#17
Constanza Vargas Parada, J Lennert Veerman
BACKGROUND: Most anal cancers are caused by the human papilloma virus (HPV) infection. The incidence is increasing, especially in high-risk individuals such as HIV-positive men. Evidence shows that the new quadrivalent HPV vaccine reduces the rates of anal intraepithelial neoplasia among men who have sex with men. OBJECTIVE: To determine whether vaccinating against HPV-related anal cancer is cost-effective in HIV-positive men in Chile. METHODS: A cost-effectiveness analysis was conducted by constructing a cohort multistate life-table-based Markov model in MS Excel in which the prevention of HPV infection was expected to influence the incidence of anal cancer in HIV-positive men...
December 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27983896/how-often-people-google-for-vaccination-qualitative-and-quantitative-insights-from-a-systematic-search-of-the-web-based-activities-using-google-trends
#18
Nicola Luigi Bragazzi, Ilaria Barberis, Roberto Rosselli, Vincenza Gianfredi, Daniele Nucci, Massimo Moretti, Tania Salvatori, Gianfranco Martucci, Mariano Martini
Nowadays, more and more people surf the Internet seeking health-related information. Information and communication technologies (ICTs) can represent an important opportunities in the field of Public Health and vaccinology. The aim of our current research was to investigate a) how often people search the Internet for vaccination-related information, b) if this search is spontaneous or induced by media, and c) which kind of information is in particular searched. We used Google Trends (GT) for monitoring the interest for preventable infections and related vaccines...
December 16, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27980529/ten-years-of-anti-hpv-vaccinations-what-do-we-know
#19
Robert Jach, Antoni Basta, Jan Kotarski, Janina Markowska, Tomasz Paszkowski, Romuald Dębski, Wojciech Rokita, Witold Kędzia, Krystyna Kiszka
Human papillomavirus (HPV) is one of the most important carcinogens in humans. Vaccines against HPV are now considered the first anti-cancer vaccinations. Since 2007, in many developed countries, there have been recommendations present for preventive vaccines against HPV. At present, the degree of implementation of these recommendations depends on a number of country-specific factors such as the health care system organization or the ways of funding. HPV vaccines are primarily to prevent the development of cervical cancer and other genital cancers...
November 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/27979747/dna-vaccination-for-cervical-cancer-a-novel-technology-platform-of-rala-mediated-gene-delivery-via-polymeric-microneedles
#20
A A Ali, C M McCrudden, J McCaffrey, J W McBride, G Cole, N J Dunne, T Robson, A Kissenpfennig, R F Donnelly, H O McCarthy
HPV subtypes (16, 18) are associated with the development of cervical cancer, with oncoproteins E6 and E7 responsible for pathogenesis. The goal of this study was to evaluate our 'smart system' technology platform for DNA vaccination against cervical cancer. The vaccination platform brings together two main components; a peptide RALA which condenses DNA into cationic nanoparticles (NPs), and a polymeric polyvinylpyrrolidone (PVP) microneedle (MN) patch for cutaneous delivery of the loaded NPs. RALA condensed E6/E7 DNA into NPs not exceeding 100nm in diameter, and afforded the DNA protection from degradation in PVP...
December 12, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
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