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Vaccination against HPV

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https://www.readbyqxmd.com/read/29474403/cross-sectional-associations-between-psychological-traits-and-hpv-vaccine-uptake-and-intentions-in-young-adults-from-the-united-states
#1
Aaron M Scherer, Heather Schacht Reisinger, Marin L Schweizer, Natoshia M Askelson, Angela Fagerlin, Charles F Lynch
Human papillomavirus (HPV) is the most prevalent sexually transmitted infection worldwide and can lead to the development of genital warts, and cancers throughout the body. Despite the availability of HPV vaccines for over a decade, uptake in the United States among adolescents and young adults remains well below national targets. While most efforts to improve HPV vaccine uptake have rightly focused on adolescents, there is still a tremendous opportunity to improve vaccination among young adults who have not been vaccinated against HPV...
2018: PloS One
https://www.readbyqxmd.com/read/29474243/anticipating-the-impact-of-human-papillomavirus-vaccination-on-us-cervical-cancer-prevention-strategies
#2
L Stewart Massad
Cervical cancer prevention guidelines are benchmarked to risk of cervical precancer. In younger age cohorts, vaccination against high-risk types of human papillomavirus (HPV) has reduced HPV 16/18 prevalence and cervical intraepithelial neoplasia. Lower prevalence of precancer will impair the sensitivity of cytology and colposcopy, but negative predictive value will rise. Training and skills maintenance will become more difficult as abnormalities become less common. Primary screening with HPV assays will become more attractive but will require HPV genotyping as most positive HPV tests will reflect non-16/18 infections with lower oncogenicity...
February 23, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29465705/non-vaccine-type-hpv-prevalence-after-vaccine-introduction-no-evidence-for-type-replacement-but-evidence-for-cross-protection
#3
Mónica Saccucci, Eduardo L Franco, Lili Ding, David I Bernstein, Darron Brown, Jessica A Kahn
BACKGROUND: We examined non-vaccine-type HPV prevalence in a community before and over the first eight years after vaccine introduction, to assess for 1) type replacement with any non-vaccine type HPV and 2) cross-protection with non-vaccine types genetically related to vaccine-type HPV. METHODS: Sexually experienced 13-26-year-old women were recruited for three cross-sectional studies from 2006-2014 (N=1180). Outcome variables were: 1) prevalence of ≥ 1 of 32 anogenital non-vaccine-type HPVs and 2) prevalence of ≥ 1 HPV type genetically related to HPV16 and HPV18...
October 4, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29458794/the-role-of-human-papillomavirus-vaccines-in-cervical-cancer-prevention-and-treatment
#4
REVIEW
Giorgio Bogani, Umberto Leone Roberti Maggiore, Mauro Signorelli, Fabio Martinelli, Antonino Ditto, Ilaria Sabatucci, Lavinia Mosca, Domenica Lorusso, Francesco Raspagliesi
Human papillomavirus (HPV) is the most common sexually transmitted disease, worldwide. Primary prevention thorough vaccination si able to reduce the burden of HPV-related lesions. Ten years ago the Food and drug Administration (FDA) approved the first vaccine against HPV. In the last decades, growing data on safety and effectiveness have been collected. In the present review we report the current knowledge on vaccine against HPV, highlighting the current value and prospective regarding the widespread diffusion of HPV vaccines...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29447271/parents-knowledge-beliefs-and-acceptance-of-the-hpv-vaccination-in-relation-to-their-socio-demographics-and-religious-beliefs-a-cross-sectional-study-in-thailand
#5
Maria Grandahl, Seung Chun Paek, Siriwan Grisurapong, Penchan Sherer, Tanja Tydén, Pranee Lundberg
Thailand has one of the world's highest prevalence of cervical cancer, mainly caused by the human papillomavirus (HPV). HPV infections can successfully be prevented by vaccination, which is available at a cost but not yet implemented in the national vaccination program. Parents play a critical role in deciding whether to vaccinate their child against HPV. Thus, the aim was to examine the association between parents' knowledge, beliefs, and acceptance of the HPV vaccination for their daughters, considering their socio-demographics and religious beliefs...
2018: PloS One
https://www.readbyqxmd.com/read/29446090/potential-lives-saved-in-73-countries-by-adopting-multi-cohort-vaccination-of-9-14-year-old-girls-against-human-papillomavirus
#6
Mark Jit, Marc Brisson
Up to 2016, low- and middle-income countries mostly introduced routine human papillomavirus (HPV) vaccination for just a single age-cohort of girls each year. However, high income countries have reported large reductions in HPV prevalence following "catch-up" vaccination of multiple age-cohorts in the year of HPV vaccine introduction. We used the mathematical model PRIME to project the incremental impact of vaccinating 10-14-year old girls compared to routine HPV vaccination only in the same year that routine vaccination is expected to be introduced for 9-year old girls across 73 low and lower-middle income countries...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29433132/-the-economic-value-of-vaccinations-a-systematic-review-of-italian-economic-evaluations-and-hta-reports
#7
Francesco Di Nardo, Sara Boccalini, Giovanna Elisa Calabrò, Andrea Marcellusi, Matteo Ruggeri, Paolo Bonanni, Raffaella Vitali, Eleonora Capannini, Francesco Saverio Mennini, Americo Cicchetti, Donatella Panatto, Roberto Gasparini, Walter Ricciardi, Chiara De Waure
INTRODUCTION: Decision-making in healthcare should rely on evidence-based approaches able to make possible a transparent and robust assessment of all the aspects related to health technologies. One of the assessment elements is represented by the efficiency that is the specific objective of economic evaluations and also of Health Technology Assessment (HTA). The collection and synthesis of evidence is the first indispensable step in order to foster a proper convey of scientific knowledge to the decision-makers...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29433128/-the-new-national-immunization-program-2017-2019-and-the-essential-care-levels-what-is-going-to-change
#8
Chiara De Waure, Leuconoe Grazia Sisti, Andrea Poscia, Walter Ricciardi
Italy is witnessing relevant challenges in the field of prevention and control of vaccine-preventable diseases. The worrying and growing phenomenon of "vaccine-hesitancy" has contributed to the reduction of vaccination coverage, undermining goals reached thanks to vaccines introduction. The new Italian National Immunization Plan (NIP) 2017-2019 and the update of the list of Essential Care Levels (LEA), approved in the current year, extend the vaccination offer based on the latest scientific evidence with the introduction of new vaccines and the enlargement of target population...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29409034/high-effectiveness-of-the-bivalent-hpv-vaccine-up-to-six-years-post-vaccination-against-incident-and-persistent-hpv-infections-in-young-dutch-females
#9
R Donken, A J King, J A Bogaards, P J Woestenberg, C J L M Meijer, H E de Melker
Background: Monitoring vaccine effectiveness (VE) in vaccination programs is of importance for assessing the impact of immunization. This study aims to estimate the VE of the bivalent HPV-vaccine against incident and 12-month persistent infections up to six years post-vaccination. Methods: In 2009/2010, girls eligible for the vaccination catch-up campaign (14-16 years of age) were enrolled into a prospective cohort. Annually, participants filled out a questionnaire and handed in a vaginal self-swab for HPV testing by SPF10-LiPA25...
February 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29392992/immunisation-rates-among-children-in-nuuk
#10
Nadja Albertsen, Ivalu Meincke Fencker, Heidi Egede Noasen, Michael Lynge Pedersen
The children immunisation programme in Greenland correlates to the one in Denmark with the addition of the Bacille Calmette-Guerin (BCG)-vaccine and the immunisation against Hepatitis B (HBV). The immunisation rate among children in Greenland has been and is currently unknown and this study aims to estimate the immunisation rates among children in Nuuk from 1 July 2015 until 30 June 2016. We did an observational cross-sectional study based on a statistical extraction identifying all children in Nuuk eligible for an immunization in the children immunisation programme from 1 July 2015 until 30 June 2016 and a review of their medical records...
December 2018: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/29382323/prevalence-of-high-risk-hpv-genotypes-categorised-by-their-quadrivalent-and-nine-valent-hpv-vaccination-coverage-and-the-genotype-association-with-high-grade-lesions
#11
María Paz-Zulueta, Ledicia Álvarez-Paredes, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Ma Encarnación Andrada Becerra, José María Rodríguez Ingelmo, María Montserrat Ruiz García, Joaquín Portilla, Miguel Santibañez
BACKGROUND: The new nine-valent vaccine against human papillomavirus (HPV) includes the four HPV genotypes (6, 11, 16, and 18) that are targeted by the older quadrivalent HPV vaccine, plus five additional oncogenic types (31, 33, 45, 52, and 58) remain significantly associated with high grade lesions. We aimed to determine the prevalence of high-risk HPV genotypes in unvaccinated subjects and the association of these genotypes with the incidence of high-grade lesions. We also assessed which, if either, of these two HPV vaccines could have prevented these cases...
January 30, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29368102/human-papilloma-virus-vaccination-among-adolescents-in-a-community-clinic-before-and-after-intervention
#12
M Varman, C Sharlin, C Fernandez, J Vasudevan, C Wichman
Human Papilloma Virus (HPV) is the most common sexually transmitted disease with over 14 million infections in 2008. Certain HPV types have been identified in up to 70% of cases of cervical and anal cancers. Despite being safe and effective, HPV vaccination rates remain low. Vaccination and demographic data was collected pre-and post-intervention. Among 13 thru 17-year-old cohort females were significantly more likely to be fully vaccinated. Assessment also found that patients insured by Medicaid were significantly more likely to be fully vaccinated than patients insured privately...
January 24, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29366703/evidence-for-single-dose-protection-by-the-bivalent-hpv-vaccine-review-of-the-costa-rica-hpv-vaccine-trial-and-future-research-studies
#13
Aimée R Kreimer, Rolando Herrero, Joshua N Sampson, Carolina Porras, Douglas R Lowy, John T Schiller, Mark Schiffman, Ana Cecilia Rodriguez, Stephen Chanock, Silvia Jimenez, John Schussler, Mitchell H Gail, Mahboobeh Safaeian, Troy J Kemp, Bernal Cortes, Ligia A Pinto, Allan Hildesheim, Paula Gonzalez
The Costa Rica Vaccine Trial (CVT), a phase III randomized clinical trial, provided the initial data that one dose of the HPV vaccine could provide durable protection against HPV infection. Although the study design was to administer all participants three doses of HPV or control vaccine, 20% of women did not receive the three-dose regimens, mostly due to involuntary reasons unrelated to vaccination. In 2011, we reported that a single dose of the bivalent HPV vaccine could be as efficacious as three doses of the vaccine using the endpoint of persistent HPV infection accumulated over the first four years of the trial; findings independently confirmed in the GSK-sponsored PATRICIA trial...
January 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29363293/safety-of-hpv-vaccines-in-the-age-of-nonavalent-vaccination
#14
Filippo Quattrone, Alice Canale, Elisa Filippetti, Alberto Tulipani, Andrea Porretta, Pier L Lopalco
To date three vaccines against human papilloma virus (HPV) have been licensed: a bivalent, a quadrivalent and, in 2014, a nonavalent vaccine. Despite the early implementation of national vaccination programs, in the majority of developed countries coverage rates remain unsatisfactory. Rumors about vaccine safety have been one of the principal obstacles for the acceptance of HPV vaccination by the public. It is therefore of primary importance to provide the public with clear and up-to-date information about HPV vaccination safety...
February 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29361344/immunogenicity-of-hpv-prophylactic-vaccines-serology-assays-and-their-use-in-hpv-vaccine-evaluation-and-development
#15
Ligia A Pinto, Joakim Dillner, Simon Beddows, Elizabeth R Unger
When administered as standard three-dose schedules, the licensed HPV prophylactic vaccines have demonstrated extraordinary immunogenicity and efficacy. We summarize the immunogenicity of these licensed vaccines and the most commonly used serology assays, with a focus on key considerations for one-dose vaccine schedules. Although immune correlates of protection against infection are not entirely clear, both preclinical and clinical evidence point to neutralizing antibodies as the principal mechanism of protection...
January 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29346307/knowledge-and-attitudes-of-general-practitioners-and-sexual-health-care-professionals-regarding-human-papillomavirus-vaccination-for-young-men-who-have-sex-with-men
#16
Samuel W D Merriel, Carrie Flannagan, Joanna M Kesten, Gilla K Shapiro, Tom Nadarzynski, Gillian Prue
Men who have sex with men (MSM) may be at higher risk for human papillomavirus (HPV)-associated cancers. Healthcare professionals' recommendations can affect HPV vaccination uptake. Since 2016, MSM up to 45 years have been offered HPV vaccination at genitourinary medicine (GUM) clinics in a pilot programme, and primary care was recommended as a setting for opportunistic vaccination. Vaccination prior to potential exposure to the virus (i.e., sexual debut) is likely to be most efficacious, therefore a focus on young MSM (YMSM) is important...
January 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29336241/generation-of-the-fluorescent-hpv16-e7-protein-for-detection-of-delivery-in-vitro
#17
Sepideh Shahbazi, Azam Bolhassani, Arash Arashkia, Esmaeil Sadroddiny
Immunotherapies targeting the human papillomavirus (HPV) oncogenic proteins, E6 and E7, are effective to treat HPV-associated cervical malignancies. In this study, two types of the fusion E7-GFP proteins (i.e., with or without linker) were expressed in different E. coli strains. Then, the efficiency of GFP and E7-GFP transfection was compared with FITC-antibody protein control using TurboFect reagent in the HEK-293T cell line. Our data indicated that both E7-GFP fusion proteins were efficiently produced in M15 E...
January 15, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29335156/adapting-cervical-cancer-screening-for-women-vaccinated-against-human-papillomavirus-infections-the-value-of-stratifying-guidelines
#18
Kine Pedersen, Emily A Burger, Mari Nygård, Ivar S Kristiansen, Jane J Kim
BACKGROUND: Several countries have implemented vaccination against human papillomavirus (HPV) for adolescent girls and must decide whether and how to adapt cervical cancer (CC) screening for these low-risk women. We aimed to identify the optimal screening strategies for women vaccinated against HPV infections and quantify the amount that could be spent to identify vaccination status among women and stratify CC screening guidelines accordingly. METHODS: We used a mathematical model reflecting HPV-induced CC in Norway to project the long-term health benefits, resources and costs associated with 74 candidate-screening strategies that varied by screening test, start age and frequency...
January 12, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29334901/monitoring-vaccine-and-non-vaccine-hpv-type-prevalence-in-the-post-vaccination-era-in-women-living-in-the-basilicata-region-italy
#19
Francesca Carozzi, Donella Puliti, Cristina Ocello, Pasquale Silvio Anastasio, Espedito Antonio Moliterni, Emilia Perinetti, Laurence Serradell, Elena Burroni, Massimo Confortini, Paola Mantellini, Marco Zappa, Géraldine Dominiak-Felden
BACKGROUND: A large free-of-charge quadrivalent HPV (qHPV) vaccination program, covering four cohorts annually (women 11, 14, 17 and 24 years), has been implemented in Basilicata since 2007. This study evaluated vaccine and non-vaccine HPV prevalence 5-7 years post-vaccination program implementation in vaccinated and unvaccinated women. METHODS: This population-based, cross-sectional study was conducted in the public screening centers of the Local Health Unit in Matera between 2012 and 2014...
January 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29334706/-analysis-of-mothers-acceptance-of-hpv-vaccination-of-adolescent-girls-in-xiamen
#20
Y F Han, Y N Zhuang, Y Li, Y Fang
Objective: To survey the mothers' acceptance of the HPV vaccination for their adolescent girls in Xiamen and to explore the influencing factors. Methods: Mothers of adolescent girls were selected by multistage cluster random sampling. Data of demography of the mothers and girls, the knowledge and attitude of cervical cancer and HPV vaccine of the mothers were collected. The influencing factors of mothers' attitudes were analyzed with univariate and multivariate logistic regression. Results: A total of 2 307 mothers were selected...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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