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Vaccination against HPV

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https://www.readbyqxmd.com/read/29683766/displaying-31rg-1-peptide-on-the-surface-of-hpv16-l1-by-use-of-a-human-papillomavirus-chimeric-virus-like-particle-induces-cross-neutralizing-antibody-responses-in-mice
#1
Xue Chen, Ting Zhang, Hongyang Liu, Yaru Hao, Guoyang Liao, Xuemei Xu
Current available human papillomavirus (HPV) vaccines are based on the major capsid protein L1 virus-like particles (VLPs), which mainly induce type-specific neutralizing antibodies against vaccine types. Continuing to add more types of VLPs in a vaccine raises the complexity and cost of production which remains the principal impediment to achieve broad implementation of HPV vaccines, particularly in developing regions. In this study, we constructed 16L1-31L2 chimeric VLP (cVLP) by displaying HPV31 L2 aa.17-38 on the h4 coil surface region of HPV16 L1, and assessed its immunogenicity in mouse model...
April 23, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29665430/awareness-of-cervical-cancer-and-willingness-to-be-vaccinated-against-human-papillomavirus-in-mozambican-adolescent-girls
#2
Azucena Bardají, Carolina Mindu, Orvalho J Augusto, Aina Casellas, Olga Cambaco, Egas Simbine, Graça Matsinhe, Eusébio Macete, Clara Menéndez, Esperança Sevene, Khátia Munguambe
Sub-Saharan Africa concentrates the largest burden of cervical cancer worldwide. The introduction of the HPV vaccination in this region is urgent and strategic to meet global health targets. This was a cross-sectional study conducted in Mozambique prior to the first round of the HPV vaccine demonstration programme. It targeted girls aged 10-19 years old identified from schools and households. Face-to-face structured interviews were conducted. A total of 1,147 adolescents were enrolled in three selected districts of the country...
April 14, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29659751/a-randomized-placebo-controlled-trial-of-the-quadrivalent-hpv-vaccine-in-hiv-infected-adults-age-27-years-or-older-aids-clinical-trials-group-protocol-a5298
#3
Timothy J Wilkin, Huichao Chen, Michelle S Cespedes, Jorge T Leon-Cruz, Catherine Godfrey, Elizabeth Y Chiao, Barbara Bastow, Jennifer Webster-Cyriaque, Qinghua Feng, Joan Dragavon, Robert W Coombs, Rachel M Presti, Alfred Saah, Ross D Cranston
Background: Adults living with HIV are at increased risk for anal and oropharyngeal cancer caused by human papillomavirus (HPV). The efficacy of HPV vaccines in this population is unknown. Methods: Phase 3, double-blind, randomized controlled trial. We assigned HIV-infected adults age 27 or older to the quadrivalent HPV (Types 6, 11, 16, 18) vaccine or placebo (1:1) stratified by sex and presence of anal high-grade squamous intraepithelial lesions on biopsy (bHSIL)...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29652958/-hpv-vaccine-implementation-in-chile-an-appraisal-from-the-social-determinants-of-health-model
#4
Loreto Fernández González
Cervical cancer is the fourth most common neoplasm in women worldwide and its incidence is associated with profound social inequities. In Chile, it is the second cause of death in women of reproductive age. The Chilean clinical guideline identifies the vaccine against Human Papillomavirus (HPV) as the main preventive measure. Since 2014, the Ministry of Health has implemented free immunization against HPV for girls and female adolescents. This article critically analyzes this public policy from the viewpoint of health equity, using as framework the Social Determinants of Health Model...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29614733/factors-that-predict-parental-willingness-to-have-their-children-vaccinated-against-hpv-in-a-country-with-low-hpv-vaccination-coverage
#5
Maria Ganczak, Barbara Owsianka, Marcin Korzeń
Background: Adolescent HPV (Human Papilloma Virus) vaccination is yet to be introduced as a mandatory program in Poland. Polish literature on factors associated with adolescent HPV vaccination is scant, despite the fact that uptake is one of the poorest in the European Union. Objectives: To assess HPV awareness and identify independent predictors for parental willingness to have their children vaccinated against HPV. Methods: All parents of first grade students from three selected high schools in Zgorzelec, Poland, who participated in parent-teacher meetings at the time the study was conducted, had their children unvaccinated regarding HPV, and who gave informed consent to participate were included...
March 31, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29588103/black-mother-s-intention-to-vaccinate-daughters-against-hpv-a-mixed-methods-approach-to-identify-opportunities-for-targeted-communication
#6
Jennifer Cunningham-Erves, Laura Forbes, Nataliya Ivankova, Tilicia Mayo-Gamble, Kendria Kelly-Taylor, Jason Deakings
OBJECTIVE: The cervical cancer disparity continues to exist and has widened between Black and non-Hispanic White women. Human Papillomavirus (HPV) vaccines could potentially reduce this disparity, yet remain underused among Black female adolescents. We investigated psychosocial and cultural factors associated with Black mothers' intentions to vaccinate their daughters against HPV, and explored views toward a HPV vaccine mandate. METHODS: In this quantitative dominant, mixed methods study, cross sectional surveys (n=237) and follow-up semi-structured interviews (n=9) were conducted with Black mothers of daughters...
March 24, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29578097/are-two-doses-of-human-papillomavirus-vaccine-sufficient-for-girls-aged-15-18-years-results-from-a-cohort-study-in-india
#7
Neerja Bhatla, Bhagwan M Nene, Smita Joshi, Pulikottil O Esmy, Usha Rani Reddy Poli, Geeta Joshi, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Priya R Prabhu, Partha Basu, Richard Muwonge, Sanjay Hingmire, Catherine Sauvaget, Eric Lucas, Michael Pawlita, Tarik Gheit, Kasturi Jayant, Sylla G Malvi, Maqsood Siddiqi, Angelika Michel, Julia Butt, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Uma Divate, Martina Willhauck-Fleckenstein, Tim Waterboer, Martin Müller, Peter Sehr, Alka Kriplani, Gauravi Mishra, Radhika Jadhav, Ranjit Thorat, Massimo Tommasino, M Radhakrishna Pillai, Rengaswamy Sankaranarayanan
Extending two-dose recommendations of HPV vaccine to girls between 15-18 years will reduce program cost and improve compliance. Immunogenicity and vaccine targeted HPV infection outcomes were compared between 1795 girls aged 15-18 years receiving two (1-180 days) and 1515 girls of same age receiving three (1-60-180 days) doses. Immunogenicity outcomes in 15-18 year old two-dose recipients were also compared with the 10-14 year old three-dose (N=2833) and two-dose (N=3184) recipients. The 15-18 year old two-dose recipients had non-inferior L1-binding antibody titres at seven months against vaccine-targeted HPV types compared to three-dose recipients at 15-18 years and three-dose recipients at 10-14 years of age...
March 22, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29567355/hepatitis-b-vaccine-non-responders-possible-mechanisms-and-solutions
#8
REVIEW
Tara Vinyette Saco, Alexandra T Strauss, Dennis K Ledford
OBJECTIVE: Hepatitis B (HBV) is a viral illness that chronically infects 240 million people worldwide, leads to cirrhotic liver disease, and increases risk of hepatocellular carcinoma. The HBV vaccine has decreased HBV infection and along with human papilloma virus (HPV) vaccine are the only vaccines that prevent cancer. Despite the effectiveness of HBV vaccine, some populations do not develop protective responses. The risk groups for poor response include those with immunosuppression or dialysis-dependent, end-stage renal disease...
March 19, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29565690/cervical-screening-in-hpv-vaccinated-populations
#9
K Canfell
Cervical screening with cytology has been the basis for substantial reductions in cervical cancer incidence and mortality in most high-income countries over the last few decades. More recently, there have been two key, parallel developments which have prompted a major re-consideration of cervical screening. The first is the emergence of evidence on the improved sensitivity of human papillomavirus (HPV) DNA testing compared to cytology, and the second is the large-scale deployment of prophylactic vaccination against HPV...
March 22, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29556461/knowledge-about-human-papillomavirus-hpv-related-oral-cancers-among-oral-health-professionals-in-university-setting-a-cross-sectional-study
#10
Shelly Arora, Srinivas Sulugodu Ramachandra, Christopher Squier
Introduction: Scientific literature suggests that human papillomavirus (HPV) infection may be associated with oral squamous cell carcinoma (OSCC). However, knowledge regarding HPV-OSCC link among oral health professionals (OHP) has been insufficient. So, the aim of this study was to assess the knowledge about HPV associated OSCC among OHP working in dental faculties in Malaysia. Methodology: Ethical committee of the University approved this study. A validated, pre-tested questionnaire was sent electronically to 224 OHP...
January 2018: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29553886/estimation-of-the-individual-residual-risk-of-cervical-cancer-after-vaccination-with-the-nonavalent-hpv-vaccine
#11
Karl-Ulrich Petry, Kaatje Bollaerts, Paolo Bonanni, Margaret Stanley, Rosybel Drury, Elmar Joura, Susanne K Kjaer, Chris J L M Meijer, Didier Riethmuller, Benoit Soubeyrand, Pierre Van Damme, Xavier Bosch
BACKGROUND: The nonavalent HPV (9vHPV) vaccine is indicated for active immunisation of individuals from the age of 9 years against cervical, vulvar, vaginal and anal premalignant lesions and cancers causally related to vaccine HPV high risk types 16, 18, 31, 33, 45, 52 and 58, and to the HPV low risk types 6 and 11, causing genital warts. OBJECTIVE: To estimate the lifetime risk (up to the age of 75 years) for developing cervical cancer after vaccinating a HPV naïve girl (e...
March 19, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29551226/can-a-single-dose-of-human-papillomavirus-hpv-vaccine-prevent-cervical-cancer-early-findings-from-an-indian-study
#12
Rengaswamy Sankaranarayanan, Smita Joshi, Richard Muwonge, Pulikottil Okkuru Esmy, Partha Basu, Priya Prabhu, Neerja Bhatla, Bhagwan M Nene, Janmesh Shaw, Usha Rani Reddy Poli, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Massimo Tommasino, Michael Pawlita, Tarik Gheit, Tim Waterboer, Peter Sehr, Madhavan Radhakrishna Pillai
BACKGROUND: Human papillomavirus (HPV) vaccination is a major strategy for preventing cervical and other ano-genital cancers. Worldwide HPV vaccination introduction and coverage will be facilitated if a single dose of vaccine is as effective as two or three doses or demonstrates significant protective effect compared to 'no vaccination'. METHODS: In a multi-centre cluster randomized trial of two vs three doses of quadrivalent HPV vaccination (GARDASIL©) in India, suspension of the vaccination due to events unrelated to the study led to per protocol and partial vaccination of unmarried 10-18 year old girls leading to four study groups, two by design and two by default...
March 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29544689/preclinical-development-of-peptide-vaccination-combined-with-oncolytic-mg1-e6e7-for-hpv-associated-cancer
#13
Matthew J Atherton, Kyle B Stephenson, Jake K Nikota, Qian N Hu, Andrew Nguyen, Yonghong Wan, Brian D Lichty
Human papilloma virus (HPV)-associated cancer is a significant global health burden and despite the presence of viral transforming antigens within neoplastic cells, therapeutic vaccinations are ineffective for advanced disease. HPV positive TC1 cells are susceptible to viral oncolysis by MG1-E6E7, a custom designed oncolytic Maraba virus. Epitope mapping of mice vaccinated with MG1-E6E7 enabled the rational design of synthetic long peptide (SLP) vaccines against HPV16 and HPV18 antigens. SLPs were able to induce specific CD8+ immune responses and the magnitude of these responses significantly increased when boosted by MG1-E6E7...
March 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29544466/knowledge-attitudes-and-practices-toward-cervical-cancer-prevention-among-women-in-kampong-speu-province-cambodia
#14
Sothy Touch, Jin-Kyoung Oh
BACKGROUND: There is little information concerning the preventive behaviors against cervical cancer among women in Cambodia, a country without organized cervical cancer screening programs and national human papillomavirus (HPV) vaccination policies. We aimed to examine the cervical cancer knowledge, attitudes, and practices as well as cervical cancer prevention methods among Cambodian women. METHODS: A community-based cross-sectional survey on cervical cancer prevention was conducted...
March 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29538565/-knowledge-and-perception-of-hpv-in-the-population-over-18-years-of-age-in-the-city-of-ipatinga-state-of-minas-gerais-brazil
#15
Mery Natali Silva Abreu, Angela Deise Soares, Diemack Alle Oliveira Ramos, Fernanda Vieira Soares, Gerson Nunes Filho, Analina Furtado Valadão, Patrícia Gonçalves da Motta
Several studies have identified misconceptions about human papillomavirus (HPV), which can lead to negligent behavior and risk to the health of the population. This article aims to assess the knowledge of men and women about HPV in the city of Ipatinga, Minas Gerais, and evaluate socioeconomic factors and preventive measures associated with such knowledge. It involved a cross-sectional study with 591 subjects living in the city, by means of stratified sampling by quotas proportional to the number of individuals by sex and age in each of the eight administrative regions of the city...
March 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29524677/hpv-vaccination-in-male-physicians-a-survey-of-gynecologists-and-otolaryngology-surgeons-attitudes-towards-vaccination-in-themselves-and-their-patients
#16
Claire Stanley, Michael Secter, Sarah Chauvin, Amanda Selk
OBJECTIVE: Attitudes and barriers towards HPV vaccination were explored in a population of male surgeons in Gynecology and Otolaryngology in Ontario, Canada. MATERIALS/METHODS: An internet-based survey was distributed to male residents and physicians affiliated with the departments of Obstetrics and Gynecology, and Otolaryngology at six Ontario universities. The survey consisted of 16 questions (3 demographic, 3 workplace exposure, 6 regarding personal vaccination, and 3 regarding patient vaccination)...
March 7, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29519885/accelerating-the-pace-of-cancer-prevention-right-now
#17
Graham A Colditz, Karen M Emmons
As a nation, we underinvest in prevention and fail to implement strategies that ensure all population groups equitably share in the return on investment in prevention research and the benefits of prevention effectiveness. There is significant evidence indicating that by applying knowledge that we already have to reduce tobacco, inactivity, and obesity (known modifiable causes of cancer), we can prevent more than 50% of cancers. Vaccination against HPV, aspirin and selective estrogen receptor modulators, and screening programs further reduce risk...
March 8, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29502634/evaluation-of-pediatric-human-papillomavirus-vaccination-provider-counseling-written-materials-a-health-literacy-perspective
#18
Rosy Chhabra, Deena J Chisolm, Barbara Bayldon, Maheen Quadri, Iman Sharif, Jessica J Velazquez, Karen Encalada, Angelic Rivera, Millie Harris, Elana Levites-Agababa, H Shonna Yin
BACKGROUND AND OBJECTIVES: Despite recommendations supporting human papillomavirus (HPV) vaccination, pediatric vaccination rates remain suboptimal in the United States; lack of tools to support provider counseling is one barrier. We sought to evaluate HPV-related counseling materials for readability, suitability, and content, and assess parent perceptions of materials, using a health literacy perspective. METHODS: A systematic search was conducted for written materials developed for HPV vaccination counseling by examining state Department of Health Web sites and associated links to local and national organizations...
March 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29484460/-human-papillomavirus-and-penile-cancer-thinking-about-measures-for-prevention
#19
REVIEW
P Schneede, B Schlenker
Two major pathways of penile carcinogenesis are known: human papillomavirus (HPV)-induced penile cancer and HPV-negative cancers associated with chronic dermatoses. Therefore, modern measures for prevention of penile cancer may for example include prophylactic HPV vaccination. The resulting B‑cell-mediated immunity to HPV capsid proteins is effective protection against future HPV infections. Contrarily when treating existing HPV infections or HPV-associated cancers an antigen-specific T‑cell immunity is necessary...
February 26, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29476028/long-term-incidence-trends-of-hpv-related-cancers-and-cases-preventable-by-hpv-vaccination-a-registry-based-study-in-norway
#20
Bo T Hansen, Suzanne Campbell, Mari Nygård
OBJECTIVES: Examine long-term incidence trends of human papillomavirus (HPV)-related cancer in Norway, and estimate the number of cancer cases preventable by vaccines against HPV 16/18 or HPV 16/18/31/33/45/52/58. DESIGN: Observational registry-based study. We extracted incident cases of HPV-related cancer during 1953-2015 from the Cancer Registry of Norway. Tumour HPV prevalence estimates from large international meta-analyses or from Norway were used to estimate the protective potential of HPV vaccines...
February 23, 2018: BMJ Open
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