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Vaccination against HPV

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https://www.readbyqxmd.com/read/28723467/human-papillomavirus-infection-and-vaccination-in-males
#1
REVIEW
Eugenio Ventimiglia, Simon Horenblas, Asif Muneer, Andrea Salonia
CONTEXT: Human papillomavirus (HPV) is the commonest sexually transmitted pathogen in humans and is linked to the aetiopathogenesis for both benign and malignant disease in men. OBJECTIVE: To evaluate and summarise the evidence for HPV infection and vaccination in men. EVIDENCE ACQUISITION: A search of Medline, PubMed, and Scopus was performed to identify articles published in English within the last 10 yr addressing HPV epidemiology, the natural history of HPV infection and its long-term consequences, and vaccination in men...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720463/incidence-rates-of-guillain-barr%C3%A3-gbs-chronic-fatigue-systemic-exertion-intolerance-disease-cfs-seid-and-postural-orthostatic-tachycardia-syndrome-pots-prior-to-introduction-of-human-papilloma-virus-hpv-vaccination-among-adolescent-girls-in-finland-2002-2012
#2
J Skufca, J Ollgren, E Ruokokoski, O Lyytikäinen, H Nohynek
BACKGROUND: In Finland a vaccination programme against human papillomavirus (HPV) was introduced in November 2013 for girls aged 11-12 years with a catchup for girls 13-15 years. Allegations that HPV vaccine is causing Guillain Barré syndrome (GBS) and non-specific diagnostic entities, such as chronic fatigue syndrome/systemic exertion intolerance disease (CFS/SEID) and postural orthostatic tachycardia syndrome (POTS), continue to surface. We examined population register-based incidence rates of CFS/SEID, GBS and POTS to provide baseline data for future HPV vaccine safety evaluations...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720462/a-novel-trivalent-hpv-16-18-58-vaccine-with-anti-hpv-16-and-18-neutralizing-antibody-responses-comparable-to-those-induced-by-the-gardasil-quadrivalent-vaccine-in-rhesus-macaque-model
#3
Fei Yin, Yajun Wang, Na Chen, Dunquan Jiang, Yefeng Qiu, Yan Wang, Mei Yan, Jianping Chen, Haijiang Zhang, Yongjiang Liu
Persistent infection with human papillomavirus (HPV) is a key factor in the development of precancerous lesions and invasive cervical cancer. Prophylactic vaccines to immunize against HPV are an effective approach to reducing HPV related disease burden. In this study, we investigated the immunogenicity and dosage effect of a trivalent HPV 16/18/58 vaccine (3vHPV) produced in Escherichia coli (E.coli), with Gardasil quadrivalent vaccine (4vHPV, Merck & Co.) as a positive control. Sera collected from rhesus macaques vaccinated with three dosage formulations of 3vHPV (termed low-, mid-, and high-dosage formulations, respectively), and the 4vHPV vaccine were analyzed by both Pseudovirus-Based Neutralization Assay (PBNA) and Enzyme-Linked Immunosorbent Assay (ELISA)...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720444/characterization-of-a-spray-dried-candidate-hpv-l2-vlp-vaccine-stored-for-multiple-years-at-room-temperature
#4
Julianne Peabody, Pavan Muttil, Bryce Chackerian, Ebenezer Tumban
HPV infections are associated with human cancers. Although three prophylactic vaccines have been approved to protect against HPV infections, the vaccines require cold-chain storage and may not be suitable for third world countries with less developed refrigeration facilities. We previously developed a bacteriophage L2 virus-like particle (VLP)-based candidate vaccine, which elicited broadly protective antibodies against diverse HPV types. Spray-drying of MS2-16L2 VLPs into a dry powder enhanced the stability of these VLPs...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720147/safety-and-immunogenicity-of-the-quadrivalent-human-papillomavirus-qhpv-vaccine-in-hiv-positive-spanish-men-who-have-sex-with-men-msm
#5
Carmen Hidalgo-Tenorio, Jessica Ramírez-Taboada, Concepción Gil-Anguita, Javier Esquivias, Mohamed Omar-Mohamed-Balgahata, Antonio SamPedro, Miguel Lopez-Ruz, Juan Pasquau
BACKGROUND: Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine were evaluated in HIV-positive Spanish MSM. The prevalence of High Squamous Intraepithelial Lesions (HSIL) and genotypes of high-risk human papillomavirus (HR-HPV) were also determined, as well as risk factors associated with the presence of HR-HPV in anal mucosa. METHODS: This is a randomised, double blind, placebo-controlled trial of the quadrivalent HPV (qHPV) vaccine...
July 18, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28718520/putting-public-health-infrastructures-to-the-test-introducing-hpv-vaccination-in-austria-and-the-netherlands
#6
Katharina T Paul, Iris Wallenburg, Roland Bal
This article presents two cases of policymaking concerning the vaccine against Human Papilloma Virus (HPV), which is sexually transmitted and carcinogenic. Our analysis focuses on its introduction in Austria and the Netherlands. In both contexts, we find prevention and screening to be at once complementary and competing public health logics and we draw on the concept of 'infrastructure' to understand their roles in shaping the reception of the vaccine. We reveal how the HPV vaccine had to be made 'good enough', much like the Pap smear (Casper and Clarke ), by means of diverse tinkering practices that transformed both the technology and the infrastructures in which they emerged...
July 17, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28717764/comprehensive-human-papillomavirus-genotyping-in-cervical-squamous-cell-carcinomas-and-its-relevance-to-cervical-cancer-prevention-in-malawian-women
#7
Brooke E Howitt, Michael Herfs, Tamiwe Tomoka, Steve Kamiza, Tarik Gheit, Massimo Tommasino, Philippe Delvenne, Christopher P Crum, Danny Milner
PURPOSE: Cervical squamous cell carcinoma (SCC) continues to be a significant cause of cancer morbidity and is the third leading cause of cancer-related death in women worldwide. In sub-Saharan Africa, cervical cancer is not only the most common female cancer but also the leading cause of cancer-related deaths in women. Malawi, in particular, has the highest burden of cervical cancer. With the increasing use of human papillomavirus (HPV) vaccination, documenting the prevalent HPV types in those high-risk populations is necessary to both manage expectations of HPV vaccination and guide future vaccine development...
June 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28714529/immunologic-responses-to-a-novel-dna-vaccine-targeting-human-papillomavirus-11-e6e7
#8
Julie Ahn, Shiwen Peng, Chien-Fu Hung, Richard B S Roden, Tzyy-Choou Wu, Simon R Best
OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a benign disease caused by human papillomavirus (HPV) types 6 and 11. Although a prophylactic vaccine against RRP is available, a therapeutic vaccine is needed to treat those already infected. The objective of our study was to design and test a DNA vaccine targeting HPV11 proteins. STUDY DESIGN: Preclinical scientific investigation. METHODS: A DNA vaccine encoding the HPV11 E6 and E7 genes linked to calreticulin (CRT) was generated...
July 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28707435/evidence-based-policy-choices-for-efficient-and-equitable-cervical-cancer-screening-programs-in-low-resource-settings
#9
Nicole G Campos, Vivien Tsu, Jose Jeronimo, Mercy Mvundura, Jane J Kim
Women in developing countries disproportionately bear the burden of cervical cancer. The availability of prophylactic vaccines against human papillomavirus (HPV) types 16 and 18, which cause approximately 70% of cervical cancers, provides reason for optimism as roll-out begins with support from Gavi, the Vaccine Alliance. However, for the hundreds of millions of women beyond the target age for HPV vaccination, cervical cancer screening to detect and treat precancerous lesions remains the only form of prevention...
July 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28706878/a-genetically-modified-attenuated-listeria-vaccine-expressing-hpv16-e7-kill-tumor-cells-in-direct-and-antigen-specific-manner
#10
Yan Yan Jia, Wei Jun Tan, Fei Fei Duan, Zhi Ming Pan, Xiang Chen, Yue Lan Yin, Xin An Jiao
Attenuated Listeria monocytogenes (L. monocytogenes, LM) induces specific CD8(+) and CD4(+) T cell responses, and has been identified as a promising cancer vaccine vector. Cervical cancer is the third most common cancer in women worldwide, with human papillomavirus (HPV), particularly type 16, being the main etiological factor. The therapeutic HPV vaccines are urgently needed. The E7 protein of HPV is necessary for maintaining malignancy in tumor cells. Here, a genetically modified attenuated LM expressing HPV16 E7 protein was constructed...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28701899/cost-effectiveness-analysis-of-the-nine-valent-hpv-vaccine-in-italy
#11
Francesco Saverio Mennini, Paolo Bonanni, Florence Bianic, Chiara de Waure, Gianluca Baio, Giacomo Plazzotta, Mathieu Uhart, Alessandro Rinaldi, Nathalie Largeron
BACKGROUND: In Italy HPV vaccination with the quadrivalent vaccine (Gardasil(®)) is offered actively and free of charge to girls aged 12 since 2007. A nine-valent vaccine (Gardasil 9(®)) received the European market authorization in 2015 to protect, with only 2 doses, against around 90% of all HPV positive cancers, over 80% of high-grade precancerous lesions and 90% of genital warts caused by HPV types 6/11. METHODS: A dynamic transmission model simulating the natural history of HPV-infections was calibrated to the Italian setting and used to estimate costs and QALYs associated with vaccination strategies...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28699820/expanded-strain-coverage-for-a-highly-successful-public-health-tool-prophylactic-9-valent-human-papillomavirus-vaccine
#12
Zhigang Zhang, Jun Zhang, Ningshao Xia, Qinjian Zhao
Human papillomavirus is considered the causative factor for cervical cancer, which accounts for approximately 5% of the global cancer burden and more than 600,000 new cases annually that are attributable to HPV infection worldwide. The first-generation prophylactic HPV vaccines, Gardasil® and Cervarix®, were licensed approximately a decade ago. Both vaccines contain the most prevalent high-risk types, HPV16 and 18, which are associated with 70% of cervical cancer. To further increase the type coverage, five additional oncogenic HPV types (31, 33, 45, 52 and 58) were added to the existing Gardasil-4 to develop a 9-valent HPV vaccine (9vHPV), Gardasil 9®, increasing the potential level of protection from ∼70% to ∼90%...
July 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28682189/perspectives-of-young-chinese-singaporean-women-on-seeking-and-processing-information-to-decide-about-vaccinating-against-human-papillomavirus-hpv
#13
Iccha Basnyat, Cheryl Lim
Human papillomavirus (HPV) vaccination uptake in Singapore is low among young women. Low uptake has been found to be linked to low awareness. Thus, this study aimed to understand active and passive vaccine information-seeking behavior. Furthermore, guided by the Elaboration Likelihood Model (ELM), this study examined young women's (aged 21-26 years) processing of information they acquired in their decision to get vaccinated. ELM postulates that information processing could be through the central (i.e., logic-based) or peripheral (i...
July 6, 2017: Women & Health
https://www.readbyqxmd.com/read/28667755/incidence-and-risk-factors-for-human-papillomavirus-infections-in-young-female-online-daters
#14
Sharon Ma, Joshua E Stern, Qinghua Feng, James P Hughes, Stephen E Hawes, Rachel L Winer
Risk factors for incident HPV infections are undefined in young women who use internet dating Web sites. From 2010-2012 we followed 18-24-year-old female internet daters (N = 164) triannually for a mean of one year. Women collected and returned self-collected vaginal samples for HPV genotyping and health and behavior questionnaires. We used Kaplan-Meier methods to estimate incidence of clinically-relevant HPV infection (high-risk HPV, HPV-6, or HPV-11) and generalized estimating equations and Firth logistic regression to identify associated risk factors...
July 1, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28666469/on-the-implications-of-desexualizing-vaccines-against-sexually-transmitted-diseases-health-policy-challenges-in-a-multicultural-society
#15
Baruch Velan, Yaacov Yadgar
Two vaccines against sexually transmitted infections are included in many national vaccination programs: Hepatitis B Virus (HBV) vaccine and Human Papilloma Virus (HPV) vaccine. The trajectories of the implementation of these two programs were marked by differences in the way the sexual context of risk was communicated to the public. These trajectories fluctuated between full accounts of the sexual nature of the infection and attempts to desexualize the vaccines. Vaccine desexualization can be achieved by withholding information of sexual context, blurring information, and distancing the age of vaccination from the age of sexual debut...
July 1, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28656100/efficacy-of-human-papillomavirus-l1-protein-vaccines-cervarix-and-gardasil-in-reducing-the-risk-of-cervical-intraepithelial-neoplasia-a-meta-analysis
#16
REVIEW
Mohammad Reza Haghshenas, Tahoora Mousavi, Motahareh Kheradmand, Mahdi Afshari, Mahmood Moosazadeh
Human papillomavirus (HPV) can induce cervical intraepithelial neoplasia (CIN). Vaccination against HPV can play an important role in CIN prevention. This study aims to estimate the efficacy of L1 protein vaccines (Cervarix and Gardasil) in CIN 1, 2, 3 risk reduction using meta-analysis. Relevant articles were identified by two independent researchers searching international databanks. After application of inclusion/exclusion criteria and quality assessment, eligible articles were entered into the final meta-analysis...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28644153/louisiana-physicians-are-increasing-hpv-vaccination-rates
#17
Donna L Williams, Courtney S Wheeler, Michelle Lawrence, Stacy S Hall, Michael Hagensee
Human papilloma virus (HPV) is a common virus that can cause genital warts and certain cancers. The HPV vaccine is effective in preventing many HPV-associated diseases, however, vaccination rates suggest many remain unprotected. This study examined successful strategies used by physicians to improve HPV vaccination rates. Providers with above average vaccination rates were identified. A representative from each provider participated in an interview to identify strategies used to boost HPV vaccination. Key strategies in ensuring vaccine completion were reminders, education, standing orders, and scheduling future vaccine appointments at time of first dose...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28641366/human-papillomavirus-vaccine-dose-effectiveness-against-incident-genital-warts-in-a-cohort-of-insured-us-females
#18
Susan Hariri, Megan S Schuler, Allison L Naleway, Matthew F Daley, Sheila Weinmann, Bradley Crane, Sophia R Newcomer, Dennis Tolsma, Lauri E Markowitz
We examined effectiveness of HPV vaccination by dose number and interval against incident genital warts in a cohort of 64,517 females in the United States during 8/2006-9/2012. Eligible females were classified into 0, 1-dose, 2-dose < 6 months apart, 2-dose ≥6 months apart, and 3-dose groups and followed until genital wart diagnosis, loss to follow-up, or end of study. Propensity score weights were used to balance baseline differences across groups. To account for latent genital warts before vaccination, 6-month and 12-month buffer periods from last and first vaccine dose, respectively, were applied...
June 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28633892/seropositivity-to-non-vaccine-incorporated-genotypes-induced-by-the-bivalent-and-quadrivalent-hpv-vaccines-a-systematic-review-and-meta-analysis
#19
Sara L Bissett, Anna Godi, Mark Jit, Simon Beddows
BACKGROUND: Human papillomavirus vaccines have demonstrated remarkable efficacy against persistent infection and disease associated with vaccine-incorporated genotypes and a degree of efficacy against some genetically related, non-vaccine-incorporated genotypes. The vaccines differ in the extent of cross-protection against these non-vaccine genotypes. Data supporting the role for neutralizing antibodies as a correlate or surrogate of cross-protection are lacking, as is a robust assessment of the seroconversion rates against these non-vaccine genotypes...
July 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28622401/impact-of-a-pharmacist-conducted-educational-program-on-human-papilloma-virus-vaccination-rates-in-a-low-socioeconomic-population-in-the-city-of-lares-pr
#20
Edda Marie Jiménez-Quiñones, Kyle Melin, Francisco Javier Jiménez-Ramírez
OBJECTIVE: To observe whether local vaccination rates are improved by a patient and physician education program on the human papillomavirus (HPV) vaccine in Farmacia San José, Lares. According to the Puerto Rico Immunization Registry, the HPV vaccine is currently underutilized. METHODS: Patients within the ages of 18 and 26 years who are current patients of Farmacia San José were contacted by phone and approached in person at the pharmacy. Once contacted, patients were provided with educational materials and counseling regarding the risks and benefits of HPV vaccination...
June 2017: Puerto Rico Health Sciences Journal
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