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https://www.readbyqxmd.com/read/28301563/nicolase-an-open-source-diode-laser-combiner-fiber-launch-and-sequencing-controller-for-fluorescence-microscopy
#1
Philip R Nicovich, James Walsh, Till Böcking, Katharina Gaus
Modern fluorescence microscopy requires software-controlled illumination sources with high power across a wide range of wavelengths. Diode lasers meet the power requirements and combining multiple units into a single fiber launch expands their capability across the required spectral range. We present the NicoLase, an open-source diode laser combiner, fiber launch, and software sequence controller for fluorescence microscopy and super-resolution microscopy applications. Two configurations are described, giving four or six output wavelengths and one or two single-mode fiber outputs, with all CAD files, machinist drawings, and controller source code openly available...
2017: PloS One
https://www.readbyqxmd.com/read/28263006/rapid-analysis-of-forensic-related-samples-using-two-ambient-ionization-techniques-coupled-to-high-resolution-mass-spectrometers
#2
Eshwar Jagerdeo, Amanda Wriston
RATIONALE: This paper highlights the versatility of interfacing two ambient ionization techniques, Laser Diode Thermal Desorption (LDTD) and Atmospheric Solids Analysis probe (ASAP), to high resolution mass spectrometers and demonstrate the method's capability to rapidly generate high-quality data from multiple sample types with minimal, if any sample preparation. METHODS: For ASAP-MS analysis of solid and liquid samples, the material was transferred to a capillary surface before being introduced into the mass spectrometer...
March 6, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28248335/external-cavity-lasing-pumped-stimulated-brillouin-scattering-in-a-high-q-microcavity
#3
Kaijun Che, Deyu Tang, Changlei Guo, Huiying Xu, Changyan Ren, Pan Zhang, Shuisen Jiang, Lujian Chen, Dan Zhang, Zhiping Cai
Stimulated Brillouin scattering (SBS) in a microcavity is usually realized by employing a wavelength tunable external cavity diode laser (TECDL) as the pump source. In this Letter, we report the observation of SBS in a high Q microcavity based on a TECDL-free scheme. The microcavity is employed as a mode-reflecting mirror for constructing a fiber-ring laser and, simultaneously, pumped by the fiber-ring lasing with intrinsic resonance latching. Several regimes are observed in a microcavity with a diameter of ∼215  μm, such as single lasing pumped SBS and multiple regular lasing pumped SBSs (single or cascaded)...
March 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28240810/ultraviolet-320-nm-laser-excitation-for-flow-cytometry
#4
William Telford, Lynn Stickland, Marco Koschorreck
Although multiple lasers and high-dimensional analysis capability are now standard on advanced flow cytometers, ultraviolet (UV) lasers (usually 325-365 nm) remain an uncommon excitation source for cytometry. This is primarily due to their cost, and the small number of applications that require this wavelength. The development of the Brilliant Ultraviolet (BUV fluorochromes, however, has increased the importance of this formerly niche excitation wavelength. Historically, UV excitation was usually provided by water-cooled argon- and krypton-ion lasers...
February 27, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28198804/investigating-carrier-localization-and-transfer-in-ingan-gan-quantum-wells-with-v-pits-using-near-field-scanning-optical-microscopy-and-correlation-analysis
#5
MinKwan Kim, Sunghan Choi, Joo-Hyung Lee, ChungHyun Park, Tae-Hoon Chung, Jong Hyeob Baek, Yong-Hoon Cho
The V-pits and potential fluctuations in InGaN/GaN multiple quantum wells (MQWs) are key factors for understanding the performance of InGaN/GaN-based light-emitting diodes (LEDs). However, photoluminescence (PL) measurements using conventional optical microscopy only provide ensemble information due to the spatial resolution limit, known as the diffraction barrier, which hinders the analysis of dislocations and potential fluctuations. Here, in order to investigate the influence of the V-pits and potential fluctuations on local optical properties, we performed nanoscopic luminescence mapping for standard and V-pit InGaN/GaN MQWs samples with different sized V-pits using near-field scanning optical microscopy (NSOM) with illumination mode (I-mode) at various laser excitation powers...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28157874/1-6%C3%A2-%C3%A2-kw-yb-fiber-amplifier-using-chirped-seed-amplification-for-stimulated-brillouin-scattering-suppression
#6
Jeffrey O White, Mark Harfouche, John Edgecumbe, Naresh Satyan, George Rakuljic, Vijay Jayaraman, Christopher Burgner, Amnon Yariv
In a high power fiber amplifier, a frequency-chirped seed interrupts the coherent interaction between the laser and Stokes waves, raising the threshold for stimulated Brillouin scattering (SBS). Moving the external mirror of a vertical cavity surface-emitting diode laser 0.2 μm in 10 μs can yield a frequency chirp of 5×10<sup>17</sup>  Hz/s at a nearly constant output power. Opto-electronic feedback loops can linearize the chirp, and stabilize the output power. The linear variation of phase with time allows multiple amplifiers to be coherently combined using a frequency shifter to compensate for static and dynamic path length differences...
January 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28095532/1060-nm-diode-hyperthermic-laser-lipolysis-the-latest-in-non-invasive-body-contouring
#7
Laura Schilling, Nazanin Saedi, Robert Weiss
Non-invasive body contouring is becoming increasingly popular in the United States. Using the 1060 nm diode laser to achieve hyperthermic temperatures within the adipose tissue with subsequent lipolysis is one of the most recent advancements in this field and is the first of its kind. This wavelength was carefully chosen to effectively target the unwanted adipocytes while sparing the overlying skin and adnexae. Appreciable results are achieved after a single treatment, and these results are comparable to other non-invasive technologies...
January 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28091850/repeated-applications-of-photodynamic-therapy-on-candida-glabrata-biofilms-formed-in-acrylic-resin-polymerized
#8
Lírian Silva de Figueiredo Freitas, Rodnei Dennis Rossoni, Antonio Olavo Cardoso Jorge, Juliana Campos Junqueira
Previous studies have been suggested that photodynamic therapy (PDT) can be used as an adjuvant treatment for denture stomatitis. In this study, we evaluated the effects of multiple sessions of PDT on Candida glabrata biofilms in specimens of polymerized acrylic resin formed after 5 days. Subsequently, four applications of PDT were performed on biofilms in 24-h intervals (days 6-9). Also, we evaluated two types of PDT, including application of laser and methylene blue or light-emitting diode (LED) and erythrosine...
April 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28040906/the-method-of-pulsed-x-ray-detection-with-a-diode-laser
#9
Jun Liu, Xiaoping Ouyang, Zhongbing Zhang, Liang Sheng, Liang Chen, Xinjian Tan, Xiufeng Weng
A new class of pulsed X-ray detection methods by sensing carrier changes in a diode laser cavity has been presented and demonstrated. The proof-of-principle experiments on detecting pulsed X-ray temporal profile have been done through the diode laser with a multiple quantum well active layer. The result shows that our method can achieve the aim of detecting the temporal profile of a pulsed X-ray source. We predict that there is a minimum value for the pre-bias current of the diode laser by analyzing the carrier rate equation, which exists near the threshold current of the diode laser chip in experiments...
December 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27958555/electro-optically-spectrum-narrowed-multiline-intracavity-optical-parametric-oscillators
#10
W K Chang, H P Chung, Y Y Chou, R Geiss, S D Yang, T Pertsch, Y H Chen
We report on the first building of an active spectral narrowing mechanism in a pulsed, multiline optical parametric oscillator (OPO) based on a novel aperiodically poled lithium niobate (APPLN) device constructed using the aperiodic optical superlattice technique. The APPLN device functions simultaneously in the system as a multi-channel optical parametric down converter (OPDC) and an electro-optic (EO) gain spectral filter working on the corresponding (multiple) signal bands. When the APPLN OPO was installed in a diode pumped Nd:YVO<sub>4</sub> laser system, highly narrowed dual-wavelength signal lines (at 1540 and 1550 nm) were observed at the output of the system through EO control of the APPLN...
December 12, 2016: Optics Express
https://www.readbyqxmd.com/read/27910521/a-low-temperature-external-cavity-diode-laser-for-broad-wavelength-tuning
#11
William G Tobias, Jason S Rosenberg, Nicholas R Hutzler, Kang-Kuen Ni
We report on the design and characterization of a low-temperature external cavity diode laser (ECDL) system for broad wavelength tuning. The performance achieved with multiple diode models addresses the scarcity of commercial red laser diodes below 633 nm, which is a wavelength range relevant to the spectroscopy of many molecules and ions. Using a combination of multiple-stage thermoelectric cooling and water cooling, the operating temperature of a laser diode is lowered to -64 °C, more than 85 °C below the ambient temperature...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27828256/propagation-of-modulated-optical-beams-carrying-orbital-angular-momentum-in-turbid-water
#12
Brandon Cochenour, Kaitlyn Morgan, Keith Miller, Eric Johnson, Kaitlin Dunn, Linda Mullen
The attenuation and temporal dispersion of beams with and without orbital angular momentum (OAM) underwater are investigated in a controlled laboratory water tank environment. Both spherical polystyrene beads and a commercial antacid are used to determine the effect of scattering particle size and shape on the results. Varying concentrations of the scattering agents were used to study the propagation of light in both minimally scattered and multiply scattered regimes (over 20 attenuation lengths). To study temporal dispersion, a custom diode seeded fiber amplified laser source is used to modulate beams up to 1 GHz, and diffractive spiral phase plates are used to compare performance over different spatial modes...
November 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27760646/-the-efficacy-of-large-spot-indirect-ophthalmoscopy-laser-alone-or-combined-with-systemic-chemotherapy-in-retinoblastoma-therapy
#13
J H Liang, Y Cheng, X Deng, Y Y Yu, X X Li
Objective: To evaluate the efficacy of large spot indirect ophthalmoscopy laser alone or combined with systemic chemotherapy in the treatment of early and middle stage retinoblastoma. Methods: Retrospective series case study. Clinical data of 21 patients (22 eyes) who were diagnosed as retinoblastoma (RB) in Peking University People's Hospital from March 2009 to August 2014 were collected. Medical and family history, ocular ultrasound, orbital and cranial MRI or CT examination of RB Children were detailed recorded...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27732068/hydrogen-isotopic-composition-of-arctic-and-atmospheric-ch4-determined-by-a-portable-near-infrared-cavity-ring-down-spectrometer-with-a-cryogenic-pre-concentrator
#14
Y Chen, Kevin K Lehmann, Y Peng, L M Pratt, J R White, S B Cadieux, B Sherwood Lollar, G Lacrampe-Couloume, T C Onstott
In this study, near-infrared continuous wave cavity ring-down spectroscopy was applied to the measurement of the δ(2)H of methane (CH4). The cavity ring-down spectrometer (CRDS) system consisted of multiple DFB laser diodes to optimize selection of spectral line pairs. By rapidly switching measurements between spectral line peaks and the baseline regions, the long-term instrumental drift was minimized, substantially increasing measurement precision. The CRDS system coupled with a cryogenic pre-concentrator measured the δ(2)H of terrestrial atmospheric CH4 from 3 standard liters of air with a precision of ±1...
October 2016: Astrobiology
https://www.readbyqxmd.com/read/27726169/selective-photoantisepsis
#15
David M Harris, Lou Reinisch
BACKGROUND AND OBJECTIVE: Selective killing of pathogens by laser is possible due to the difference in absorption of photon energy by pathogens and host tissues. The optical properties of pathogenic microorganisms are used along with the known optical properties of soft tissues in calculations of the laser-induced thermal response of pathogen colonies embedded in a tissue model. The objective is to define the laser parameters that optimize pathogen destruction and depth of the bactericidal effect...
October 10, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27677521/spectroscopic-and-device-aspects-of-nanocrystal-quantum-dots
#16
Jeffrey M Pietryga, Young-Shin Park, Jaehoon Lim, Andrew F Fidler, Wan Ki Bae, Sergio Brovelli, Victor I Klimov
The field of nanocrystal quantum dots (QDs) is already more than 30 years old, and yet continuing interest in these structures is driven by both the fascinating physics emerging from strong quantum confinement of electronic excitations, as well as a large number of prospective applications that could benefit from the tunable properties and amenability toward solution-based processing of these materials. The focus of this review is on recent advances in nanocrystal research related to applications of QD materials in lasing, light-emitting diodes (LEDs), and solar energy conversion...
September 28, 2016: Chemical Reviews
https://www.readbyqxmd.com/read/27661573/method-for-predicting-junction-temperature-distribution-in-a-high-power-laser-diode-bar
#17
Dae-Suk Kim, Caleb Holloway, Bongtae Han, Avram Bar-Cohen
A hybrid experimental/numerical method is proposed for predicting the junction temperature distribution in a high-power laser diode (LD) bar with multiple emitters. A commercial water-cooled LD bar with multiple emitters is used to illustrate and validate the proposed method. A unique experimental setup is developed and implemented first to measure the average junction temperatures of the LD bar emitters. After measuring the heat dissipation of the LD bar, the effective heat transfer coefficient of the cooling system is determined inversely from the numerical simulation using the measured average junction temperature and the heat dissipation...
September 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27630957/comparative-morphologic-evaluation-and-occluding-effectiveness-of-nd-yag-co2-and-diode-lasers-on-exposed-human-dentinal-tubules-an-invitro-sem-study
#18
Mini Saluja, Harpreet Singh Grover, Pankaj Choudhary
INTRODUCTION: Dentinal hypersensitivity is one of the most common problem, encountered in dental practice but has least predictable treatment outcome. The advent of lasers in dentistry has provided an additional therapeutic option for treating dentinal hypersensitivity. Although various lasers have been tried over a period of time to treat dentinal hypersensitivity, but still the doubt persist as to which laser leads to maximum dentinal tubular occlusion and is most suitable with minimal hazardous effects...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27615808/orbital-angular-momentum-based-space-division-multiplexing-for-high-capacity-underwater-optical-communications
#19
Yongxiong Ren, Long Li, Zhe Wang, Seyedeh Mahsa Kamali, Ehsan Arbabi, Amir Arbabi, Zhe Zhao, Guodong Xie, Yinwen Cao, Nisar Ahmed, Yan Yan, Cong Liu, Asher J Willner, Solyman Ashrafi, Moshe Tur, Andrei Faraon, Alan E Willner
To increase system capacity of underwater optical communications, we employ the spatial domain to simultaneously transmit multiple orthogonal spatial beams, each carrying an independent data channel. In this paper, we show up to a 40-Gbit/s link by multiplexing and transmitting four green orbital angular momentum (OAM) beams through a single aperture. Moreover, we investigate the degrading effects of scattering/turbidity, water current, and thermal gradient-induced turbulence, and we find that thermal gradients cause the most distortions and turbidity causes the most loss...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27581309/a-multiport-mr-compatible-neuroendoscope-spanning-the-gap-between-rigid-and-flexible-scopes
#20
Sunil Manjila, Margherita Mencattelli, Benoit Rosa, Karl Price, Georgios Fagogenis, Pierre E Dupont
OBJECTIVE Rigid endoscopes enable minimally invasive access to the ventricular system; however, the operative field is limited to the instrument tip, necessitating rotation of the entire instrument and causing consequent tissue compression while reaching around corners. Although flexible endoscopes offer tip steerability to address this limitation, they are more difficult to control and provide fewer and smaller working channels. A middle ground between these instruments-a rigid endoscope that possesses multiple instrument ports (for example, one at the tip and one on the side)-is proposed in this article, and a prototype device is evaluated in the context of a third ventricular colloid cyst resection combined with septostomy...
September 2016: Neurosurgical Focus
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