Yoon-Ah Kim, Celine Abueva, Andrew Padalhin, So Young Park, Ha Young Lee, Hyun-Seok Ryu, Phil-Sang Chung, Seung Hoon Woo
Objective: The submandibular gland (SMG) produces the most saliva, and factors such as aging and chemotherapy can affect its structure and function. However, there are only temporary treatments available for salivary hypofunction. This study aimed to evaluate the effects of photobiomodulation (PBM) on the function of SMG by using a rat animal model and vismodegib, an antagonist of the sonic hedgehog (SHH) pathway. Methods: Vismodegib (10 mg/kg) drug was gavaged orally for 14 days in rats to significantly decrease the SHH signaling proteins (SHH, protein patched homolog 1 [PTCH1], smoothened protein [SMO], glioma-associated oncogene homolog 1 [GLI1]), induce damage in SMG tissue, and affect salivary functional markers AQP5 and Keratin5...
February 2, 2024: Photobiomodulation, photomedicine, and laser surgery