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Congenital pseudarthrosis tibia

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https://www.readbyqxmd.com/read/29664876/what-factors-influence-union-and-refracture-of-congenital-pseudarthrosis-of-the-tibia-a-multicenter-long-term-study
#1
Hitesh Shah, Benjamin Joseph, Binu V S Nair, Devaki B Kotian, In Ho Choi, Benjamin Stephens Richards, Charles Johnston, Vrisha Madhuri, Matthew B Dobbs, Mark Dahl
OBJECTIVE: To identify factors influencing union of congenital pseudarthrosis of the tibia (CPT), refractures, and integrity of the tibia at maturity. METHODS: Data of 119 children operated for Crawford-type IV CPT and followed-up till skeletal maturity were analyzed. Logistic regression and recursive partitioning analyses were used to test associations between several variables and the outcome. RESULTS: Primary union occurred in 86% of children...
April 16, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29410461/in-silico-clinical-trials-for-pediatric-orphan-diseases
#2
A Carlier, A Vasilevich, M Marechal, J de Boer, L Geris
To date poor treatment options are available for patients with congenital pseudarthrosis of the tibia (CPT), a pediatric orphan disease. In this study we have performed an in silico clinical trial on 200 virtual subjects, generated from a previously established model of murine bone regeneration, to tackle the challenges associated with the small, pediatric patient population. Each virtual subject was simulated to receive no treatment and bone morphogenetic protein (BMP) treatment. We have shown that the degree of severity of CPT is significantly reduced with BMP treatment, although the effect is highly subject-specific...
February 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310362/wrapping-grafting-for-congenital-pseudarthrosis-of-the-tibia-a-preliminary-report
#3
An Yan, Hai-Bo Mei, Kun Liu, Jiang-Yan Wu, Jin Tang, Guang-Hui Zhu, Wei-Hua Ye
OBJECTIVE: Treatment of congenital pseudarthrosis of the tibia (CPT) remains a challenge. The autogenic iliac bone graft is important consistent of treatment for CPT. The purpose of this study was to investigate the role of wrapping autogenic iliac bone graft in improvement of the curing opportunities of CPT. METHODS: We combined Ilizarov fixator with intramedullary rodding of the tibia and wrapping autogenic iliac bone graft for treatment 51 cases of CPT between 2007 and 2010...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29241817/salvage-of-congenital-pseudarthrosis-of-the-tibia-by-the-induced-membrane-technique-followed-by-a-motorised-lengthening-nail
#4
T Pollon, J Sales de Gauzy, T Pham, C Thévenin Lemoine, F Accadbled
An 18-year-old male with neurofibromatosis type I was treated for congenital pseudarthrosis of the tibia using the Masquelet induced-membrane technique with internal fixation by retrograde implantation of a transplantar intramedullary nail. Bone healing was obtained at the expense of malunion with external rotation and 5.5cm of lower limb shortening. A motorised intramedullary-lengthening nail (Fitbone® , Wittenstein, Igersheim, Germany) was implanted. This treatment was successful in correcting the rotational malalignment and limb length discrepancy...
February 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28597058/-flexion-and-extension-osteotomy-of-the-knee
#5
T Diermeier, A B Imhoff, K Beitzel
OBJECTIVES: Flexion and extension osteotomy of the knee for symptomatic malalignment in the sagittal plane. INDICATIONS: Congenital/posttraumatic bony deficiencies in flexion/pathologic hyperextension in the knee. Additional treatment for ligament reconstruction. CONTRAINDICATIONS: Absolute: Infection, critical soft tissue situation, circulatory disorders. Relative: Osteoporosis, heavy smoker, obesity, reduced patient compliance. SURGICAL TECHNIQUE: Diagnostic arthroscopy of the knee...
August 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28580399/does-pamidronate-enhance-the-osteogenesis-in-mesenchymal-stem-cells-derived-from-fibrous-hamartoma-in-congenital-pseudarthrosis-of-the-tibia
#6
Vrisha Madhuri, Smitha Elizabeth Mathew, Karthikeyan Rajagopal, Sowmya Ramesh, B Antonisamy
Neurofibromatosis type 1 (NF1) is a commonly occurring genetic disorder in children. Mutation in the NF1 gene has its implication in poor osteoblastic capabilities. We hypothesised that pamidronate will enhance the osteoblastic potential of the mesenchymal stem cells (MSCs) derived from lipofibromatosis tissue of children with congenital pseudarthrosis tibia (CPT) associated with NF1. In this study, bone marrow MSCs (BM MSCs) and CPT MSCs were obtained from three patients undergoing salvage surgeries/bone grafting (healthy controls) and those undergoing excision of the hamartoma and corrective surgeries respectively...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28562492/congenital-pseudarthrosis-of-the-tibia-in-children-should-we-defer-surgery-until-3-years-old
#7
Yaoxi Liu, Haibo Mei, Guanghui Zhu, Kun Liu, Jiangyan Wu, Jin Tang, Rongguo He
Currently, the timing of surgery for congenital pseudarthrosis of the tibia (CPT) remains controversial. The aim of this study was to investigate the results of treatment of pseudarthrosis of the tibia in children younger than 3 years of age. A retrospective study was carried out to explore the relationship between postoperative complications and the age of surgery in children with CPT. The analysis was carried out on 42 patients with Crawford type IV CPT treated with a combined surgical technique between 2008 and 2012...
January 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28559144/vascularised-fibula-or-induced-membrane-to-treat-congenital-pseudarthrosis-of-the-tibia-a-multicentre-study-of-18-patients-with-a-mean-9-5-year-follow-up
#8
F Vigouroux, G Mezzadri, R Parot, A Gazarian, S Pannier, F Chotel
BACKGROUND: The objective of this study was to compare outcomes of two surgical techniques used to treat congenital pseudarthrosis of the tibia (CPT), the induced membrane technique (IM) and the transfer of the contralateral vascularised fibula (VF). HYPOTHESIS: The IM technique produces similar outcomes to those of VF grafting in terms of healing and function, while being simpler and having a lower complication rate. MATERIAL AND METHOD: This retrospective multicentre study included 18 patients with a mean age of 2...
September 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28437289/congenital-pseudarthrosis-of-the-tibia
#9
Courtney O'Donnell, James Foster, Ryan Mooney, Corey Beebe, Nathan Donaldson, Travis Heare
No abstract text is available yet for this article.
April 21, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/28328566/physeal-and-subphyseal-distraction-osteogenesis-in-atrophic-type-congenital-pseudarthrosis-of-the-tibia-efficacy-and-safety
#10
Woo Young Jang, Yoon Hyo Choi, Moon Seok Park, Won Joon Yoo, Tae-Joon Cho, In Ho Choi
PURPOSE: To examine the efficacy, safety, and clinical outcomes of distraction osteogenesis through the physis (PDO) or through subphyseal osteotomy (SPDO) in patients with atrophic-type congenital pseudarthrosis of tibia with proximal tibial dysplasia. METHODS: To validate the efficacy and safety of PDO and SPDO, radiographic and clinical parameters were compared between 5 patients who underwent proximal tibial metaphyseal or metadiaphyseal lengthening as a control (group 1) and 7 patients who underwent PDO or SPDO (group 2)...
March 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28213747/bone-morphogenetic-protein-2-for-the-treatment-of-congenital-pseudarthrosis-of-the-tibia-or-persistent-tibial-nonunion-in-children-and-adolescents-a-retrospective-study-with-a-minimum-2-year-follow-up
#11
Tim N Hissnauer, Norbert Stiel, Kornelia Babin, Martin Rupprecht, Michael Hoffmann, Johannes M Rueger, Ralf Stuecker, Alexander S Spiro
There is a lack of studies reporting on rhBMP-2 application in pediatric orthopaedics, although few reports demonstrated promising results of the use of rhBMP-2 in children, especially for spine fusion and for the treatment of congenital pseudarthrosis of the tibia. The objectives of this study were (1) to examine clinical and radiographic healing after rhBMP-2 application for the treatment of congenital pseudarthrosis of the tibia (CPT) or persistent tibial nonunion in children and adolescents, and (2) to investigate the safety of rhBMP-2 use in these cases...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28070823/relationship-between-postoperative-complications-and-fibular-integrity-in-congenital-pseudarthrosis-of-the-tibia-in-children
#12
Yao-Xi Liu, Hai-Bo Mei, Guang-Hui Zhu, Rong-Guo He, Kun Liu, Jin Tang, Jiang-Yan Wu, Wei-Hua Ye, Xin Hu, Qian Tan, An Yan, Sheng-Xiang Huang, Xiao-Qian Tan, Ting Lei
BACKGROUND: This study aimed to investigate the relationship between postoperative complications and fibular integrity in congenital pseudarthrosis of the tibia (CPT) in children. METHODS: A retrospective study was performed in 59 patients with Crawford type IV CPT who were treated with combined surgical technique from 2007 to 2011. The patients were divided into two groups, the CPT with fibular pseudarthrosis (group A) and CPT with intact fibula groups (group B), on the basis of fibula status after the union of CPT...
June 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27938581/-correlative-study-between-x-ray-type-after-healing-of-congenital-pseudarthrosis-of-the-tibia-in-children-and-postoperative-refracture
#13
Y X Liu, H B Mei, K Liu, J Y Wu, J Tang, R G He, G H Zhu, W H Ye, X Hu, A Yan, Y Z Yi, N Zhang
Objective: To investigate the relationship between postoperative X-ray type in 2 years after healing of congenital pseudarthrosis of the tibia(CPT) and refracture of CPT in children. Methods: A retrospective study was performed on 67 children patients with Crawford type Ⅳ CPT who were treated with combined surgeries from December 2007 to August 2012.There were 46 male and 21 female patients with 37 cases with left CPT and 30 cases with right CPT. There were 12 cases with proximal tibia dysplasia, 56 cases with neurofibromatosis type 1...
June 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27787808/evaluation-of-complications-associated-with-off-label-use-of-recombinant-human-bone-morphogenetic-protein-2-rhbmp-2-in-pediatric-orthopaedics
#14
Norbert Stiel, Tim N Hissnauer, Martin Rupprecht, Kornelia Babin, Carsten W Schlickewei, Johannes M Rueger, Ralf Stuecker, Alexander S Spiro
The off-label use of recombinant human bone morphogenetic protein-2 to promote bone healing in adults has significantly increased in recent years, while reports of recombinant human bone morphogenetic protein-2 application in children and adolescents are very rare. The aim of this study was to evaluate the safety of single and repetitive recombinant human bone morphogenetic protein-2 use in pediatric orthoapedics. Therefore we reviewed the medical records of 39 patients who had been treated with recombinant human bone morphogenetic protein-2 at our institution...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27770774/combination-of-intramedullary-rod-wrapping-bone-grafting-and-ilizarov-s-fixator-for-the-treatment-of-crawford-type-iv-congenital-pseudarthrosis-of-the-tibia-mid-term-follow-up-of-56-cases
#15
Guang-Hui Zhu, Hai-Bo Mei, Rong-Guo He, Yao-Xi Liu, Kun Liu, Jin Tang, Jiang-Yan Wu
BACKGROUND: The purpose of this study was to investigate the initial union rate, refracture rate and residual deformities of congenital pseudarthrosis of the tibia (CPT), using combined surgery including pseudarthrosis resection, intramedullary rodding, autogenous iliac bone grafting and Ilizarov's fixator, with a mean 5.2 years follow-up. METHODS: We retrospectively reviewed the records and diagrams of patients with Crawford type IV congenital pseudarthrosis of the tibia between February 2007 and March 2010...
October 22, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27519821/prevalence-of-neurofibromatosis-type-1-in-congenital-pseudarthrosis-of-the-tibia
#16
REVIEW
Kjell Van Royen, Hilde Brems, Eric Legius, Johan Lammens, Armand Laumen
UNLABELLED: A strong relationship between congenital pseudarthrosis of the tibia (CPT) and neurofibromatosis type 1 (NF1) has been suggested, but prevalence varies widely throughout the literature and the criteria used for diagnosis are very heterogeneous. Literature focus is mainly on treatment and no specific review on the prevalence of NF1 has been published. Based on our own observations, we hypothesized the prevalence of NF1 in patients with CPT to be higher than what is previously accepted...
September 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27406218/femoral-overgrowth-in-children-with-congenital-pseudarthrosis-of-the-tibia
#17
COMPARATIVE STUDY
Mi Hyun Song, Moon Seok Park, Won Joon Yoo, Tae-Joon Cho, In Ho Choi
BACKGROUND: Having observed a tendency towards femoral overgrowth (FO) of the affected limb in children with atrophic-type congenital pseudarthrosis of the tibia (CPT), we aimed to identify the incidence of, contributors to, and patterns of FO among such children. METHODS: We retrospectively evaluated 55 children with CPT, 22 with prepseudarthrosis and 33 with atrophic-type CPT from 1989 to 2012. FO was defined as an affected femoral segment ≥10 mm longer than the contralateral segment...
July 12, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27261960/rhbmp-2-and-intramedullary-fixation-in-congenital-pseudarthrosis-of-the-tibia
#18
B Stephens Richards, Terrence D Anderson
BACKGROUND: In congenital pseudarthrosis of the tibia, use of intramedullary (IM) fixation and autogenous bone graft has long been the standard of care. This study was undertaken to determine whether the addition of rhBMP-2 to this treatment method further enhances healing potential. METHODS: Twenty-one patients with congenital pseudarthrosis of the tibia were evaluated. Fifteen of these patients had neurofibromatosis type 1 (NF1). All had IM fixation and autogenous bone graft, followed by a BMP-soaked collagen sponge wrapped around both the fracture site and bone graft...
April 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27036507/transplantar-intramedullary-locking-nailing-in-childhood-congenital-pseudarthrosis-of-the-tibia-a-report-of-3-cases
#19
A Chalopin, S Pesenti, E Peltier, K Bin, F Launay, J-L Jouve
The treatment objectives in congenital pseudarthrosis of the tibia are bone consolidation and a restored lower-limb axis. They are difficult to achieve, and various surgical techniques have been described, with varying results in terms of bone consolidation and complications. The present study reports clinical and radiographic results in 3 patients managed by the same original technique of transplantar intramedullary nailing using a custom-made proximal locking nail, without surgical approach or resection of the pseudarthrosis site...
June 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27018684/the-evolution-of-free-vascularized-bone-transfer-a-40-year-experience
#20
G Ian Taylor, Russell J Corlett, Mark W Ashton
BACKGROUND: The first successful free vascularized bone flap was performed on June 1, 1974 (and reported in 1975), using the fibula. This was followed by the iliac crest based on the superficial circumflex iliac artery in 1975 and then the deep circumflex iliac artery in 1978. METHODS: A total of 384 transfers using fibula (n = 198), iliac crest (n = 180), radius (n = 4), rib (n = 1), and metatarsal (n = 1) were used between June of 1974 and June of 2014 for reconstruction of the mandible (n = 267), maxilla (n = 20), clavicle (n = 1), humerus (n = 8), radius and ulna (n = 21), carpus (n = 3), pelvis (n = 2), femur (n = 11), tibia (n = 47), and foot bones (n = 4)...
April 2016: Plastic and Reconstructive Surgery
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