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Intra articular joint injection

Zhenyang Mao, Bing Yue, You Wang, Mengning Yan, Kerong Dai
BACKGROUND: Intra-articular injection of tranexamic acid (TXA) is known to be effective in controlling blood loss after total knee arthroplasty (TKA). However, this method has some disadvantages, such as TXA leakage due to soft tissue release. Peri-articular injection provides an alternative to intra-articular administration of TXA. This study aimed to evaluate the effects of peri-articular injection of TXA in reducing blood loss after TKA and compare them to those of intra-articular TXA injection...
October 19, 2016: BMC Musculoskeletal Disorders
Terry K Morgan, Emilie Jensen, Jeong Lim, Russell Riggs
BACKGROUND: Intra-articular hyaluronic acid (HA) injection is an intermediate option between analgesics and knee joint replacement in patients with osteoarthritis (OA). Our objective was to test whether image-guided HA injections may improve knee OA outcomes after 6 months of treatment independent of potential covariates. METHODS: This is a retrospective case series with multivariate outcome-based analysis of 207 consecutive adult patients with mild to severe knee OA treated at a single out-patient clinic employing fluoroscopy-guided HA injections...
December 2015: Sports Medicine—Open
Kyung Hee Do, Sang Ho Ahn, Rodney Jones, Sung Ho Jang, Su Min Son, Dong Gyu Lee, Hee Kyung Cho, Gyu Sik Choi, Yun-Woo Cho
OBJECTIVES: Sacroiliac joint (SIJ) injections have been used to provide short-term relief of SIJ pain. In this study, the authors investigated a new technique using a superior approach. METHODS: Twenty four patients with chronic SI joint paint were recruited. Each patient was treated with a single SIJ intra-articular injection plus a periarticular injection of local anesthetic and corticosteroid in one procedure. Technical accuracy of the intra-articular procedure was determined by having 2 independent observers review and rate the quality of arthrograms obtained...
October 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Larissa Correa Hermeto, Rafael De Rossi, Paulo Henrique de Affonseca Jardim, Aureo Evangelista Santana, Jaqueline de Carvalho Rinaldi, Luis Antonio Justulin
PURPOSE: To compare two different experimental models of osteoarthritis in rabbits: intra-articular collagenase injection and anterior cruciate ligament transection. METHODS: Ten adult rabbits were randomly divided in two groups: COLL (collagenase group) and ACLT (anterior cruciate ligament transection). The COLL group was treated with 0.5 ml collagenase solution (2mg collagenase/0.5 ml sterile PBS), and the ACTL group was subjected to anterior cruciate ligament...
September 2016: Acta Cirúrgica Brasileira
L Arendt-Nielsen, G-L Jiang, R DeGryse, C C Turkel
OBJECTIVES: OnabotulinumtoxinA (onabotA) attenuates peripheral nociceptive transduction and consequently neuronal firing. The aim of this mechanistic study was to evaluate the effect of intra-articular (IA) onabotA in patients with painful knee osteoarthritis (OA). METHOD: We conducted a double-blind, randomized, placebo-controlled, 12-week trial using a single ultrasound-guided IA injection of onabotA (200 U). Patients (N = 121) were randomized to receive onabotA (n = 61) or placebo (n = 60)...
October 13, 2016: Scandinavian Journal of Rheumatology
Flora Lucena, Vanessa Foletto, Lucas Zanon Mascarin, Carlos Rogério Tonussi
AIMS: Rheumatoid arthritis brings great burdens to the patients. In addition to the highly expensive treatment, they are commonly associated with severe side-effects. In such context, the research for safe and affordable treatments is needed. MAIN METHODS: Arthritis was induced by CFA (0.5mg/mL) in female wistar rats. Trypsin was given p.o. (2.95mg/kg; 2mL) 24 hs after the intra-articular CFA injection. Articular incapacitation was measured daily by counting the paw elevation time (PET; s) during 1-min periods of stimulated walk, throughout the 7-days after intra-articular CFA injection...
October 8, 2016: Life Sciences
Young Kyun Lee, Guen Young Lee, Joon Woo Lee, Eugene Lee, Heung Sik Kang
We evaluated and compared the effectiveness of intra-articular injection of hip joint using hyaluronic acid and steroid in patients with femoroacetabular impingement (FAI). Thirty patients with FAI clinically and radiologically were enrolled and underwent hip injection using steroid (TA) or hyaluronic acid (HA) at 0-weeks with cross-over injection at 2-weeks in patients without clinical response of decrease of pain intensity less than 2-point. Patients were followed up to 12-weeks for pain intensity (Numeric rating scale, NRS: 0-10), hip disability score (HOOS), oral medication and adverse events...
November 2016: Journal of Korean Medical Science
Andrew Raines, Mei-Shu Shih, Lorraine Chua, Chen-Wei Su, Scheffer Cg Tseng, Julie O'Connell
Osteoarthritis (OA) is a progressive degenerative joint disease and to date, no disease modifying osteoarthritis drug exist. Amniotic membrane and umbilical cord products have been used clinically in several diseases due to their anti-inflammatory and anti-scarring properties. In the present study, we sought to evaluate whether a particulate amniotic membrane and umbilical cord (AM/UC) matrix could aid in attenuating disease progression. Lewis rats underwent medial meniscus transection (MMT) to induce OA. Two weeks after surgery, animals received intra-articular injections (50 μL) of either 50 µg/µL or 100 µg/µL particulate AM/UC or saline control and were subsequently euthanized 1 or 4 weeks later...
October 5, 2016: Tissue Engineering. Part A
Giuseppe Milano
Intra-articular injection of 0.5% bupivacaine repeated once a week for 5 consecutive weeks might not have deleterious effects on either normal or osteoarthritic knee joints. The chondrotoxic effect of local anesthetics previously reported on in vitro studies was not confirmed by in vivo observations on an animal model.
October 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Caroline C Gillespie, Stephen B Adams, George E Moore
OBJECTIVE: To determine common methods for intra-articular injections and variables associated with the risk of septic arthritis following intra-articular injection in the horse. STUDY DESIGN: Cross-sectional survey. SAMPLE POPULATION: Equine veterinarians. METHODS: A link to an online survey was distributed to equine practitioners in 2014. Responses for descriptive data were tabulated. Data on infection rates obtained from medical records were analyzed...
October 1, 2016: Veterinary Surgery: VS
J L Leatherwood, K L Gehl, J A Coverdale, C E Arnold, R A Dabareiner, K N Walter, E D Lamprecht
Fourteen yearling Quarter horses (351 to 470 kg) were utilized in a randomized complete block design to evaluate potential of glucosamine hydrochloride (HCl) to mitigate intra-articular inflammation following a single inflammatory insult. Horses were blocked by BW, age, and sex, and randomly assigned to treatments for a 98-d experiment. Treatments consisted of a control diet (CON; = 7) fed 1% BW per d (as-fed) of concentrate only or a treatment diet ( = 7) of concentrate top dressed with 30 mg/kg BW glucosamine HCl (99...
August 2016: Journal of Animal Science
Mustafa Soner Özcan, Mahmut Kalem, Menekşe Özçelik, Ercan Şahin, Sanem Çakar, Nazlı Hayırlı, Oya Evirgen, Feyhan Ökten
BACKGROUND AND OBJECTIVES: In this study it was aimed to examine the histological and morphometric effects on cartilage structure of intra-articular application of levobupivacaine to the shoulder joint. METHODS: In twenty New Zealand adult male rabbits, 35 shoulders were used for the study and prepared in 5 groups of 7. These groups were defined as Groups L1, L2, L3 and L4 which were right shoulders administered with 0.25% and 0.5% levobupivacaine, Group C which were left shoulders as the control group and Groups S1 and S2 which were left shoulders administered with 0...
September 28, 2016: Revista Brasileira de Anestesiologia
A Martínez-Martínez, J García-Espinosa, F Ruiz-Santiago, L Guzmán-Álvarez, M M Castellano-García
OBJECTIVE: To evaluate the usefulness of ultrasound-guided versus fluoroscopy-guided injection in CT arthrography and MR arthrography. MATERIAL AND METHODS: We reviewed all CT arthrography and MR arthrography studies done at our center between October 1, 2014 and October 1, 2015. We analyzed 32 studies: 26 with fluoroscopic guidance and 6 with ultrasound guidance. We compared the two techniques on the following parameters: presence of sufficient contrast material in the joint, extravasation or injection of contrast material in the soft tissues (presence of contrast material in the psoas or other soft tissues), and intra-articular gas bubbles...
September 27, 2016: Radiología
Ana T G Guerrero, Larissa G Pinto, Fernando Q Cunha, Sérgio H Ferreira, Jose C Alves-Filho, Waldiceu A Verri, Thiago M Cunha
BACKGROUND: Toll-like receptors (TLRs) including TLR4 and their signal pathways contribute to the pathogenesis of arthritis. Herein, we evaluated the mechanisms underlying the hyperalgesic response caused by TLR4 activation in the tibio-tarsal joint in mice. METHODS: Joint inflammatory hyperalgesia was induced by intra-articular (ia) injection of LPS (lipopolysaccharide- TLR4 agonist) in C57BL/6, TLR4, TLR2, MyD88, TRIF, TNFR1/2 and IL-1R1 knockout ((-/-)) mice...
August 24, 2016: Pharmacological Reports: PR
Jin Cheng, Xiaoqing Hu, Linghui Dai, Xin Zhang, Bo Ren, Weili Shi, Zhenlong Liu, Xiaoning Duan, Jiying Zhang, Xin Fu, Wenqing Chen, Yingfang Ao
Osteoarthritis (OA) is a common debilitating joint disorder, there's still no available disease-modifying drug for OA currently. This study aims to explore the role of TAK1 in OA pathogenesis and therapeutic efficiency of TAK1 inhibition for OA. The contribution of TAK1 to OA pathogenesis was investigated by intra-articular injection of TAK1-encoding adenovirus in rats. TAK1 inhibitor 5Z-7-induced expression changes of extracellular matrix (ECM)-related genes were detected by real-time PCR. The protective effect of 5Z-7 against OA progression was evaluated in a post-traumatic OA rat model...
September 29, 2016: Scientific Reports
M Ricci, G M Micheloni, M Berti, F Perusi, E Sambugaro, E Vecchini, B Magnan
PURPOSE: Osteoarthritis (OA) is a progressive, chronic and degenerative joint disease characterized by a loss of articular cartilage. Treatment of OA is largely palliative based on nonsteroidal anti-inflammatory drugs, opioids and injections of steroids. Regarding conservative treatment, intra-articular injections of hyaluronic acid (HA) can play a role in early symptomatic knee OA. MATERIALS AND METHODS: Between August 2015 and September 2015, sixty patients (32 males and 28 females) between 40 and 70 years old were randomly allocated into two groups: Half were treated with three weekly intra-articular injections of hyaluronic acid 1...
September 28, 2016: Musculoskeletal Surgery
Małgorzata Piechota, Jarosław Maczuch, Jarosław Skupiński, Karolina Kukawska-Sysio, Wojciech Wawrzynek
Snapping hip syndrome is an audible or palpable snap in a hip joint during movement which may be accompanied by pain or locking. It is typically seen in young athletes performing activities requiring repeated extreme movements of the hip. It may also follow a physical trauma, intramuscular injections or surgeries. There are two main forms of snapping hip: extra- or intra-articular. Extra-articular snapping hip is elicited by an abnormal movement of specific tendons and is divided into two forms: internal and external...
September 2016: Journal of Ultrasonography
Isabel Andia, Nicola Maffulli
Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action...
September 28, 2016: Sports Medicine
Varun Singla, Yatindra K Batra, Neerja Bharti, Vijay G Goni, Neelam Marwaha
BACKGROUND: Despite widespread use of steroids to treat sacroiliac joint (SIJ) pain, their duration of pain reduction is short. Platelet-rich plasma (PRP) can potentially enhance tissue healing and may have a longer-lasting effect on pain. OBJECTIVES: To assess the efficacy and safety of PRP compared with methylprednisolone in ultrasound-guided SIJ injection for low back pain. STUDY DESIGN: Prospective randomized open blinded end-point (PROBE) study...
September 27, 2016: Pain Practice: the Official Journal of World Institute of Pain
Szu-Hsuan Chen, Ta-Shen Kuan, Mu-Jung Kao, Wei-Ting Wu, Li-Wei Chou
Osteoarthritis (OA) is a degenerative disorder resulting from loss of joint cartilage and underlying bone and causes pain and loss of function. The treatment of knee OA is still a challenge because of the poor self-regeneration capacity of cartilage. The nonsurgical interventions include control of the aggravating factor (such as weight control and the use of walking aids), symptomatic treatment (such as acetaminophen or nonsteroidal anti-inflammatory drugs), prolotherapy, and viscosupplementation. However, the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) has not been widely used because of lack of clinical evidence and several limitations in patients with severe knee OA...
2016: Clinical Interventions in Aging
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