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Intra articular joint injection

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https://www.readbyqxmd.com/read/29792929/recent-advances-in-intra-articular-drug-delivery-systems-for-osteoarthritis-therapy
#1
REVIEW
Pierre Maudens, Olivier Jordan, Eric Allémann
Osteoarthritis (OA) is the most common degenerative disease of the joint. Despite many reports and numerous clinical trials, OA is not entirely understood, and there is no effective treatment available for this disease. To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections...
May 21, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29789008/pharmacological-effects-of-n-2-2-2-2-6-dichlorophenyl-amino-phenyl-acetyl-oxy-ethyl-hyaluronamide-diclofenac-etalhyaluronate-si-613-a-novel-sodium-hyaluronate-derivative-chemically-linked-with-diclofenac
#2
Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda, Kenji Miyamoto
BACKGROUND: Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with diclofenac (DF), diclofenac etalhyaluronate (SI-613), which is a potentially safer and more effective treatment for OA knee pain. In this study, we evaluated the pharmacological effects of SI-613 in experimental arthritis models. METHODS: We compared the analgesic and anti-inflammatory effects of intra-articularly administered SI-613, hyaluronic acid (HA), and of orally administered diclofenac sodium (DF-Na) in rat silver nitrate-induced arthritis model and rabbit antigen-induced arthritis model...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29785258/intra-articular-biomaterials-assisted-delivery-to-treat-temporomandibular-joint-disorders
#3
Khandmaa Dashnyam, Jung-Hwan Lee, Nandin Mandakhbayar, Guang-Zhen Jin, Hae-Hyoung Lee, Hae-Won Kim
The temporomandibular joint disorder, also known as myofascial pain syndrome, is considered one of the prevalent chronic pain diseases caused by muscle inflammation and cartilage degradation in head and neck, and thus influences even biopsychosocial conditions in a lifetime. There are several current treatment methodologies relieving inflammation and preventing degradation of the joint complex. One of the promising non-surgical treatment methods is an intra-articular injection of drugs such as corticosteroids, analgesics, and anti-depressants...
January 2018: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29782979/chondroitin-sulfate-from-sturgeon-bone-ameliorates-pain-of-osteoarthritis-induced-by-monosodium-iodoacetate-in-rats
#4
Yingjiao Sun, Guozhuan Zhang, Qian Liu, Xudong Liu, Lei Wang, Jianfeng Wang, Lishuang Liang
Chondroitin sulfate (CS) is an important component of the extracellular matrix of cartilage and has been widely used as one of the main drugs for the treatment of joint pain-related nutraceuticals and medicines. Sturgeon bone (SB) is the main waste during deep processing of sturgeons in fishery production. The present study was evaluated the therapeutic effect of CS from SB (CSSB) on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) pain and further explored the potential medicinal value of CSSB. The OA pain model was induced by intra-articular injection of MIA and then treated with CSSB...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29779621/inhibition-of-notch-signaling-pathway-temporally-postpones-the-cartilage-degradation-progress-of-temporomandibular-joint-arthritis-in-mice
#5
Xueting Luo, Yangmei Jiang, Ruiye Bi, Nan Jiang, Songsong Zhu
PURPOSE: The aim of this study is to explore the role of Notch signaling pathway in the initiation and progression of temporomandibular joint osteoarthritis (TMJOA). METHODS: 48 mice were divided into DAPT-TMJOA, Control-TMJOA and Control-Sham groups. Animals received discectomy/Sham surgery in their right TMJ, following the DAPT/saline intra-articular injections every week. Mice were sacrificed at 1/4/8 weeks post-surgery. Safranin-O and H&E staining were performed on the TMJ sections for the modified Mankin's score...
May 2, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29775732/il4-10-fusion-protein-has-chondroprotective-anti-inflammatory-and-potentially-analgesic-effects-in-the-treatment-of-osteoarthritis
#6
C Steen-Louws, J Popov-Celeketic, S C Mastbergen, K Coeleveld, C E Hack, N Eijkelkamp, M Tryfonidou, S Spruijt, J A G van Roon, F P J G Lafeber
OBJECTIVE: Effective disease-modifying drugs for osteoarthritis (DMOAD) should preferably have chondroprotective, anti-inflammatory, and analgesic activity combined in a single molecule. We developed a fusion protein of IL4 and IL10 (IL4-10 FP), in which the biological activity of both cytokines is preserved. The present study evaluates the chondroprotective, anti-inflammatory, and analgesic activity of IL4-10 FP in in vitro and in vivo models of osteoarthritis. METHODS: Human osteoarthritic cartilage tissue and synovial tissue were cultured with IL4-10 FP...
May 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29772338/hyaluronic-acid-an-efficient-biomacromolecule-for-treatment-of-inflammatory-skin-and-joint-diseases-a-review-of-recent-developments-and-critical-appraisal-of-preclinical-and-clinical-investigations
#7
REVIEW
Li Hui Chen, Jian Feng Xue, Zhi Yong Zheng, Muhammad Shuhaidi, Hnin Ei Thu, Zahid Hussain
Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29770595/repair-potential-of-non-surgically-delivered-induced-pluripotent-stem-cell-derived-chondrocytes-in-a-rat-osteochondral-defect-model
#8
Yeri Alice Rim, Yoojun Nam, Narae Park, Jennifer Lee, Sung-Hwan Park, Ji Hyeon Ju
Human induced pluripotent stem cells (hiPSCs) are thought to be an alternative cell source for future regenerative medicine. hiPSCs may allow unlimited production of cell types that have low turnover rates and are difficult to obtain such as autologous chondrocytes. In this study, we generated hiPSC-derived chondrogenic pellets and chondrocytes were isolated. To confirm the curative effects, chondrogenic pellets and isolated chondrocytes were transplanted into rat joints with osteochondral defects. Isolated hiPSC-derived chondrocytes were delivered in the defect by a single intra-articular injection...
May 16, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29764447/efficacy-of-intra-articular-hypertonic-dextrose-prolotherapy-versus-normal-saline-for-knee-osteoarthritis-a-protocol-for-a-triple-blinded-randomized-controlled-trial
#9
Regina Wing Shan Sit, Ricky Wing Keung Wu, Kenneth Dean Reeves, David Rabago, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Vincent Chi Ho Chung, Samuel Yeung Shan Wong
BACKGROUND: Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have marginal effectiveness, and surgery is reserved for severe symptomatic KOA. Dextrose Prolotherapy (DPT) is an evidence-based injection-based therapy for chronic musculoskeletal conditions including KOA. The standard "whole joint" injection method includes intra-articular injection and multiple extra-articular injections at soft tissue bony attachments...
May 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29753041/nociceptin-orphanin-fq-opioid-peptide-nop-receptor-and-%C3%A2%C2%B5-opioid-peptide-mop-receptors-both-contribute-to-the-anti-hypersensitive-effect-of-cebranopadol-in-a-rat-model-of-arthritic-pain
#10
Klaus Schiene, Wolfgang Schröder, Klaus Linz, Stefanie Frosch, Thomas M Tzschentke, Ulla Jansen, Thomas Christoph
Cebranopadol is a novel, first-in-class analgesic with agonist activity at the nociceptin/orphanin FQ opioid peptide (NOP) receptor as well as the classical opioid peptide receptors. This study investigated the anti-hypersensitive effect of cebranopadol in a rat model of arthritic pain. Selective antagonists were used to probe the involvement of the NOP receptor and the µ-opioid peptide (MOP) receptors. Experimental mono-arthritis was induced by intra-articular injection of complete Freund's adjuvant into the left hind knee joint...
May 9, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29747385/mithramycin-a-alleviates-osteoarthritic-cartilage-destruction-by-inhibiting-hif-2%C3%AE-expression
#11
Moon-Chang Choi, Woo Hee Choi
Osteoarthritis (OA) is the most common and increasing joint disease worldwide. Current treatment for OA is limited to control of symptoms. The purpose of this study was to determine the effect of specificity protein 1 (SP1) inhibitor Mithramycin A (MitA) on chondrocyte catabolism and OA pathogenesis and to explore the underlying molecular mechanisms involving SP1 and other key factors that are critical for OA. Here, we show that MitA markedly inhibited expressions of matrix-degrading enzymes induced by pro-inflammatory cytokine interleukin-1β (IL-1β) in mouse primary chondrocytes...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29743011/procaine-and-saline-have-similar-effects-on-articular-cartilage-and-synovium-in-rat-knee
#12
Aysun Ankay Yilbas, Basak Akca, Berkem Buyukakkus, Elham Bahador Zirh, Dilara Zeybek, Filiz Uzumcugil, Fatma Saricaoglu
BACKGROUND: Intra-articular local anaesthetics are widely used for providing postoperative analgesia and decreasing the need for opioids. Procaine has proven positive effects in carpal tunnel syndrome and chondromalacia patella. However, the effect of procaine on articular cartilage has not yet been studied. The aim of this study was to evaluate the effects of intra-articular procaine injection on the articular cartilage and the synovium. METHODS: Twenty adult Sprague-Dawley rats were enrolled in the study...
May 9, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29737459/safety-of-intra-articular-transplantation-of-lentivirally-transduced-mesenchymal-stromal-cells-for-haemophilic-arthropathy-in-a-non-human-primate
#13
Tsukasa Ohmori, Hiroaki Mizukami, Yuko Katakai, Sho Kawai, Hitoyasu Nakamura, Makoto Inoue, Tsugumine Shu, Hideharu Sugimoto, Yoichi Sakata
Joint bleeding and resultant arthropathy are major determinants of quality of life in haemophilia patients. We previously developed a mesenchymal stromal cell (MSC)-based treatment approach for haemophilic arthropathy in a mouse model of haemophilia A. Here, we evaluated the long-term safety of intra-articular injection of lentivirally transduced autologous MSCs in non-human primates. Autologous bone-marrow-derived MSCs transduced with a lentiviral vector expressing coagulation factor VIII (FVIII) were injected into the left knee joint of cynomolgus monkeys...
May 8, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29734232/corticosteroid-injections-into-lumbar-facet-joints-a-prospective-randomized-double-blind-placebo-controlled-trial
#14
David J Kennedy, Lisa Huynh, Joe Wong, Ryan Mattie, Josh Levin, Matthew Smuck, Byron J Schneider
BACKGROUND: Corticosteroid injections into the intra-articular (IA) zygapophysial (z-joints) are frequently utilized to treat this cause of low back pain. No studies have been done on the efficacy of IA corticosteroids in those with z-joint pain confirmed by dual comparative medial branch blocks (MBB). OBJECTIVE: To determine if an injection of a corticosteroid into lumbar z-joints is effective in reducing pain and the need for radiofrequency neurotomy (RFN). DESIGN: Double-Blind, prospective, randomized, placebo controlled trial SETTING: Academic Medical Center PATIENTS: 28 subjects with z-joint pain confirmed by MBBs...
May 4, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29729412/sustained-intra-articular-release-of-celecoxib-in-an-equine-repeated-lps-synovitis-model
#15
Stefan M Cokelaere, Saskia G M Plomp, Esther de Boef, Mike de Leeuw, Sophie Bool, Chris H A van de Lest, P René van Weeren, Nicoline M Korthagen
Synovial inflammation is an important characteristic of arthritic disorders like osteoarthritis and rheumatoid arthritis. Orally administered non-steroidal anti-inflammatory drugs (NSAIDs) such as celecoxib are among the most widely prescribed drugs to manage these debilitating diseases. Intra-articular delivery in biodegradable in situ forming hydrogels overcomes adverse systemic effects and prolongs drug retention in the joint. In this study two formulations of celecoxib (40 mg/g and 120 mg/g) in a propyl-capped PCLA-PEG-PCLA triblock copolymer were sequentially evaluated in a multiple LPS challenge equine synovitis model...
May 2, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29723651/quadrupedal-rodent-gait-compensations-in-a-low-dose-monoiodoacetate-model-of-osteoarthritis
#16
Emily H Lakes, Kyle D Allen
BACKGROUND: Rodent gait analysis provides robust, quantitative results for preclinical musculoskeletal and neurological models. In prior work, surgical models of osteoarthritis have been found to result in a hind limb shuffle-stepping gait compensation, while a high dose monoiodoacetate (MIA, 3 mg) model resulted in a hind limb antalgic gait. However, it is unknown whether the antalgic gait caused by MIA is associated with severity of degeneration from the high dosage or the whole-joint degeneration associated with glycolysis inhibition...
April 22, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29722575/isolated-intra-articular-injections-of-hyaluronic-acid-or-corticosteroids-or-combined-with-joint-lavage-in-patients-with-severe-hemophilic-arthropathy-of-the-knee-are-any-of-these-interventions-really-effective
#17
Emerito Carlos Rodriguez-Merchan, Leonard A Valentino
The aim of this review is to explore the scientific rationale and evidence for a potential benefit of joint lavage followed by intra-articular injection of hyaluronic acid and/or corticosteroids in patients with severe hemophilic arthropathy of the knee (SHAK). Areas covered: This article is a narrative review of the evidence for potential benefits of joint lavage followed by intra-articular injection of hyaluronic acid and corticosteroids in SHAK compared with osteoarthritis of the knee in non-hemophilia patients...
May 3, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29721463/trapeziometacarpal-joint-osteoarthritis-a-prospective-trial-on-two-widespread-conservative-therapies
#18
Lorenzo Rocchi, Antonio Merolli, Laura Giordani, Caterina Albensi, Calogero Foti
Introduction: The trapeziometacarpal (TMC) joint osteoarthritis (OA) is at the origin of important secondary functional disability to pinch as well as a painful grip. Several conservative therapies are often considered in the early stages of TMC OA to decrease pain, recover function and slow the evolution of OA. They include massage therapy, heat applications, stretching of the first web span and assisted mobilization of the TMC joint. However, as with other arthritic joints, many physicians often suggest administering intra-articular corticosteroids...
October 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/29704190/tissue-engineering-in-osteoarthritis-current-status-and-prospect-of-mesenchymal-stem-cell-therapy
#19
Gun-Il Im
Osteoarthritis (OA) is the most common form of arthritis. Over the last 20 years, attempts have been made to regenerate articular cartilage to overcome the limitations of conventional treatments. As OA is generally associated with larger and diffuse involvement of articular surfaces and alteration of joint homeostasis, a tissue engineering approach for cartilage regeneration is more difficult than in simple chondral defects. Autologous and allogeneic mesenchymal stem cells (MSCs) have rapidly emerged as investigational products for cartilage regeneration...
April 27, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29703511/validation-of-musculoskeletal-ultrasound-in-the-assessment-of-experimental-gout-synovitis
#20
Esperanza Naredo, Juan Pablo Medina, Sandra Pérez-Baos, Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
The objective of this study was to validate musculoskeletal ultrasound (US) in a rabbit model of acute gout. Acute gout was induced by intra-articular injection of monosodium urate (MSU) crystals in 10 rabbits; the 3 controls received vehicle. Rabbit knees were assessed by B-mode and power Doppler (PD) US 24 and 72 h after injections. After 72 h, all rabbits were euthanized. US discriminated between the MSU-injected and control groups with respect to the different inflammatory findings at both at 24 and 72 h and for MSU crystal-related findings after 24 h of injection...
April 24, 2018: Ultrasound in Medicine & Biology
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