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Intra articular joint injection

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https://www.readbyqxmd.com/read/28910961/paeonol-alleviates-interleukin-1%C3%AE-induced-inflammatory-responses-in-chondrocytes-during-osteoarthritis
#1
Mingran Liu, Shuqiang Zhong, Ruifeng Kong, Hong Shao, Chunyan Wang, Hongying Piao, Wentao Lv, Xiaojie Chu, Yan Zhao
Interleukin-1β (IL-1β)-induced inflammatory responses in chondrocytes play an important role in the pathogenesis of osteoarthritis (OA). Searching medicines that affect IL-1β-mediated chondrocytes function is critical in developing therapies for OA. Paeonol, as an important component in traditional Chinese medicine, has anti-inflammatory activity and can offer therapy for a multitude of inflammatory-related diseases. The purpose of this study was to investigate whether paeonol could alleviate the progression of OA through inhibition of IL-1β-induced inflammatory responses in chondrocytes...
September 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28902756/sacroiliac-joint-dysfunction-in-the-athlete-diagnosis-and-management
#2
Rebecca Peebles, Christopher E Jonas
Sacroiliac joint (SIJ) dysfunction is a common cause of low back pain in the athlete, especially in sports with repetitive, asymmetric loading. Complex anatomy and broad pain referral pattern make diagnosis difficult. Identifying three or more positive physical examination maneuvers for the SIJ improves examination sensitivity and specificity. Imaging is rarely helpful in establishing the diagnosis but is often used to rule out other pathology. Conservative management with activity modification, medication, physical therapy, manipulation and bracing is first line treatment...
September 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28902105/clinical-effectiveness-of-intra-articular-pulsed-radiofrequency-compared-to-intra-articular-corticosteroid-injection-for-management-of-atlanto-occipital-joint-pain-a-prospective-randomized-controlled-pilot-study
#3
So Min Shin, Sang Gyu Kwak, Dong Gyu Lee, Min Cheol Chang
STUDY DESIGN: A prospective randomized controlled pilot study OBJECTIVE.: We aimed to assess the effectiveness of pulsed radiofrequency (PRF) stimulation on the atlanto-occipital (AO) joint in patients with chronic joint pain. Additionally, we compared the effects of AO intra-articular (IA) PRF and AO IA corticosteroid. SUMMARY OF BACKGROUND DATA: IA injection of corticosteroids into the AO joint is widely used for the management of head and upper cervical pain, and its effectiveness has been shown in previous studies...
September 8, 2017: Spine
https://www.readbyqxmd.com/read/28888902/a-small-molecule-inhibitor-of-the-wnt-pathway-sm04690-as-a-potential-disease-modifying-agent-for-the-treatment-of-osteoarthritis-of-the-knee
#4
Vishal Deshmukh, Haide Hu, Charlene Barroga, Carine Bossard, Sunil Kc, Luis Dellamary, Joshua Stewart, Kevin Chiu, Maureen Ibanez, Melinda Pedraza, Tim Seo, Long Do, Shawn Cho, Joseph Cahiwat, Betty Tam, Jeyanesh R S Tambiah, John Hood, Nancy E Lane, Yusuf Yazici
OBJECTIVES: Osteoarthritis (OA) is a degenerative disease characterized by loss of cartilage and increased subchondral bone within synovial joints. Wnt signaling affects the pathogenesis of OA as this pathway modulates both the differentiation of osteoblasts and chondrocytes, and production of catabolic proteases. A novel small molecule Wnt pathway inhibitor, SM04690, was evaluated in a series of in vitro and in vivo animal studies to determine its effects on chondrogenesis, cartilage protection and synovial-lined joint pathology...
September 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28885454/attenuation-of-early-phase-inflammation-by-cannabidiol-prevents-pain-and-nerve-damage-in-rat-osteoarthritis
#5
Holly T Philpott, Melissa O'Brien, Jason J McDougall
Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a non-euphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine if CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. OA was induced in male Wistar rats (150-175g) by intra-articular injection of sodium monoiodoacetate (MIA; 3mg)...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28882752/mechanosensitive-ion-channels-msics-in-articular-nociceptors-drive%C3%A2-mechanical-allodynia-in-osteoarthritis-oa
#6
B H He, M Christin, S Mouchbahani-Constance, A Davidova, R Sharif-Naeini
OBJECTIVE: Osteoarthritis (OA) is a disabling and highly prevalent condition affecting millions worldwide. Pain is the major complaint of OA patients and is presently inadequately managed. It manifests as mechanical allodynia, a painful response to innocuous stimuli such as joint movement. Allodynia is due in part to the sensitization of articular nociceptors to mechanical stimuli. These nociceptors respond to noxious mechanical stimuli applied to their terminals via the expression of depolarizing high-threshold mechanosensitive ion channels (MSICs) that convert painful mechanical forces into electrical signals...
September 5, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28874727/effectiveness-of-glenohumeral-joint-dilatation-for-treatment-of-frozen-shoulder-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Wei-Ting Wu, Ke-Vin Chang, Der-Sheng Han, Chung-Hsun Chang, Fu-Sui Yang, Chih-Peng Lin
The objective was to explore the effectiveness of glenohumeral joint distension for the treatment of frozen shoulder. We searched electronic data sources including PubMed, Scopus, and Embase from the earliest records available to February 2017. Eleven randomized controlled trials including at least one pair of comparisons between capsular distension and a reference treatment were included, comprising 747 participants. Patients' characteristics, details of reference treatments, aspects of capsular distension therapy, and outcome measurement were evaluated at three points in time: baseline, early following intervention, and at the trial's end...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871338/comparison-of-the-effectiveness-on-intra-articular-and-subcutaneous-tnf-inhibitor-in-rheumatoid-arthritis-patients
#8
Fangze Zhang, Cuili Ma
The objective of this study is to evaluate the efficacy of single intra-articular (IA) injection of tumor necrosis factor α (TNFα) inhibitor in knee joints comparing with subcutaneous injection in rheumatoid arthritis (RA) patients. Forty-eight RA patients with 73 knee arthritis were divided into three groups, group A: received a single injection of TNF inhibitor into knee joints; group B: received regular subcutaneous injection; and group C: received both of the regimen as groups A and B. Ultrasound, erythrocyte sedimentation rate, C-reactive protein (CRP), patients' global visual analogue scale (VAS), and 28-joint Disease Activity Score (DAS28) were collected pre- and post-therapy 4 weeks...
September 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28866048/subcutaneous-lipoatrophy-and-skin-depigmentation-secondary-to-tmj-intra-articular-corticosteroid-injection
#9
Nicolás Patricio Skármeta, Fernando Ariel Hormazábal, Juan Alvarado, Ana Maria Rodriguez
Chronic orofacial pain is a complex multidimensional experience that produces disability and impairment of normal mandibular function. Overall estimations of chronic orofacial pain prevalence are 7 to 11% of the general population. Temporomandibular disorders (TMDs) are one of the most prevalent chronic orofacial pain conditions, with temporomandibular joint (TMJ) arthralgia accounted for 30.1% of TMD patients. Interventional procedures are often used in pain and palliative medicine to achieve reasonable and cost-effective pain relief...
August 5, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28860852/expression-of-matrix-metalloproteinases-and-components-of-the-endocannabinoid-system-in-the-knee-joint-are-associated-with-biphasic-pain-progression-in-a-rat-model-of-osteoarthritis
#10
Agnieszka Pajak, Magdalena Kostrzewa, Natalia Malek, Michal Korostynski, Katarzyna Starowicz
Matrix metalloproteinases (MMPs) are considered important in articular cartilage breakdown during osteoarthritis (OA). Similarly, the endocannabinoid system (ECS) is implicated in joint function and modulation of nociceptive processing. Functional interplay between ECS and MMPs has been recently indicated. Here, we tested if changes in the expression of selected MMPs and major ECS elements temporally correlate with the intensity of OA-related pain. Knee OA was induced in male Wistar rats by intra-articular sodium monoiodoacetate injection...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28844566/role-of-trka-signalling-and-mast-cells-in-the-initiation-of-osteoarthritis-pain-in-the-monoiodoacetate-model
#11
J Sousa-Valente, L Calvo, V Vacca, R Simeoli, J C Arévalo, M Malcangio
OBJECTIVE: Aiming to delineate novel neuro-immune mechanisms for NGF/TrkA signalling in osteoarthritis (OA) pain, we evaluated inflammatory changes in the knee joints following injection of monoiodoacetate (MIA) in mice carrying a TrkA receptor mutation (P782S; TrkA KI mice). METHOD: In behavioural studies we monitored mechanical hypersensitivity following intra-articular MIA and oral prostaglandin D2 (PGD2) synthase inhibitor treatments. In immunohistochemical studies we quantified joint mast cell numbers, calcitonin gene-related peptide expression in synovia and dorsal root ganglia, spinal cord neuron activation and microgliosis...
August 24, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28841497/injectable-hydrogels-for-treatment-of-osteoarthritis-a-rheological-study
#12
Benjamin von Lospichl, Shabnam Hemmati-Sadeghi, Pradip Dey, Tilo Dehne, Rainer Haag, Michael Sittinger, Jochen Ringe, Michael Gradzielski
Osteoarthritis (OA) is a disabling condition especially in the elderly population. The current therapeutic approaches do not halt the OA progression or reverse joint damage. In order to overcome the problem of rapid clearance of hyaluronic acid (HA), a standard viscosupplement for OA, we investigated the rheological properties of a relatively non-degradable dendritic polyglycerol sulfate (dPGS) hydrogel to determine a suitable concentration for intra articular injections that mimics HA in terms of its viscoelastic and mechanical properties...
August 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28836846/a-technique-of-needle-redirection-at-a-single-craniolateral-site-for-injection-of-three-compartments-of-the-equine-stifle-joint
#13
Meredith R A Herdrich, Shelby E Arrieta, Brad B Nelson, David D Frisbie, Valerie J Moorman
OBJECTIVE To determine accuracy for a technique of needle redirection at a single craniolateral site for injection of 3 compartments of the equine stifle joint, describe the external needle position, and identify the location of the needle tip within each joint compartment. SAMPLE 24 equine cadaver stifle joints. PROCEDURES Stifle joints were placed in a customized stand. After the needle was placed, external needle position was measured and recorded. Each joint compartment (medial and lateral compartments of the femorotibial joint and the femoropatellar joint) was injected with a solution containing iodinated contrast medium, water, and dye...
September 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28835778/effectiveness-of-intra-articular-therapies-in-osteoarthritis-a-literature-review
#14
REVIEW
Peter Wehling, Christopher Evans, Jana Wehling, William Maixner
Osteoarthritis is a painful, chronic disease with widespread burden on patients, communities, health and social care systems. Conservative therapies, such as nonpharmacological interventions, systemic drug treatment and intra-articular therapies are used before resorting to surgery; nonetheless, disease control often remains inadequate. Recent advances in osteoarthritis management have aimed to provide greater variety of treatment options. Here, we summarize a targeted literature review evaluating efficacy and safety of intra-articular therapies for osteoarthritis...
August 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28827659/tdag8-trpv1-and-asic3-involved-in-establishing-hyperalgesic-priming-in-experimental-rheumatoid-arthritis
#15
Wei-Shan Hsieh, Chia-Chi Kung, Shir-Ly Huang, Shih-Chang Lin, Wei-Hsin Sun
Rheumatoid arthritis (RA), characterized by chronic inflammation of synovial joints, is often associated with ongoing pain and increased pain sensitivity. High hydrogen ion concentration (acidosis) found in synovial fluid in RA patients is associated with disease severity. Acidosis signaling acting on proton-sensing receptors may contribute to inflammation and pain. Previous studies focused on the early phase of arthritis (<5 weeks) and used different arthritis models, so elucidating the roles of different proton-sensing receptors in the chronic phase of arthritis is difficult...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28822720/juvenile-idiopathic-arthritis-practice-patterns-among-oral-and-maxillofacial-surgeons
#16
Brian E Kinard, Shelly Abramowicz
PURPOSE: The purpose of this investigation is to assess the current clinical practices by oral and maxillofacial surgeons (OMSs) in the United States regarding diagnosis and treatment of temporomandibular joint (TMJ) involvement in children with juvenile idiopathic arthritis (JIA). MATERIALS AND METHODS: We implemented a cross-sectional survey of academic OMSs in the United States via an electronic survey. The survey included respondent demographic data, patient volumes, diagnostic methods, and management practices for children with JIA and TMJ involvement...
July 25, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28807034/exosomes-from-embryonic-mesenchymal-stem-cells-alleviate-osteoarthritis-through-balancing-synthesis-and-degradation-of-cartilage-extracellular-matrix
#17
Yafei Wang, Dongsheng Yu, Zhiming Liu, Fang Zhou, Jun Dai, Bingbing Wu, Jing Zhou, Boon Chin Heng, Xiao Hui Zou, Hongwei Ouyang, Hua Liu
BACKGROUND: Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have been implicated in many diseases and are known to participate in many physiological processes. Here, we investigate the therapeutic potential of exosomes from human embryonic stem cell-induced mesenchymal stem cells (ESC-MSCs) in alleviating osteoarthritis (OA). METHODS: Exosomes were harvested from conditioned culture media of ESC-MSCs by a sequential centrifugation process...
August 14, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28803211/melatonin-protects-chondrocytes-from-impairment-induced-by-glucocorticoids-via-nad-dependent-sirt1
#18
Wei Yang, Xiaomin Kang, Na Qin, Feng Li, Xinxin Jin, Zhengmin Ma, Zhuang Qian, Shufang Wu
Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in osteoarthritis patients, which is occasionally accompanied with the serious side effects of glucocorticoids in collagen-producing tissue. Melatonin is the major hormone released from the pineal gland and its beneficial effects on cartilage has been suggested. In the present study, we investigated the protective role of melatonin on matrix degeneration in chondrocytes induced by dexamethasone (Dex). The chondrocytes isolated from mice knee joint were treated with Dex, melatonin, EX527 and siRNA targeted for SIRT6, respectively...
October 2017: Steroids
https://www.readbyqxmd.com/read/28797764/inflammatory-pain-assessment-in-the-arthritis-of-the-temporomandibular-joint-in-rats-a-comparison-between-two-phlogistic-agents
#19
Joana Cláudia Bezerra de Araújo, Delane Viana Gondim, André Luiz Cunha Cavalcante, Mario Roberto Pontes Lisboa, Gerly Anne de Castro Brito, Mariana Lima Vale
Temporomandibular joint (TMJ) disorders are a group of conditions that result in TMJ pain, which frequently limits basic daily activities. Experimental models that allow the study of the mechanisms underlying these inflammatory and pain conditions are of great clinical relevance. The aim of this study was to evaluate nociception, inflammation and participation of the macrophage/microglia cells in the arthritis of the TMJ induced by two phlogistic agents. 84 rats were divided into 2 groups: Zy, which received zymosan intra-articularly, or Cg, which received carrageenan intra-articularly...
August 8, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28794657/repeated-administration-of-mazindol-reduces-spontaneous-pain-related-behaviors-without-modifying-bone-density-and-microarchitecture-in-a-mouse-model-of-complete-freund-s-adjuvant-induced-knee-arthritis
#20
L E Robledo-González, A Martínez-Martínez, V M Vargas-Muñoz, R I Acosta-González, R Plancarte-Sánchez, M Anaya-Reyes, C Fernández Del Valle-Laisequilla, J G Reyes-García, J M Jiménez-Andrade
BACKGROUND: The role of dopaminergic system in the development of rheumatoid arthritis-related pain, a major symptom in this disease, has not been explored. Therefore, the anti-nociceptive effect of mazindol, a dopamine uptake inhibitor, was evaluated in a model of complete Freund's adjuvant (CFA)-induced arthritis. Furthermore, as studies have shown that the dopaminergic system regulates bone metabolism, the effect of mazindol on bone mass and microarchitecture was determined. METHODS: Adult ICR male mice received intra-articular injections of either CFA or saline into the right knee joint every week...
2017: Journal of Pain Research
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