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Intra articular joint injection

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https://www.readbyqxmd.com/read/29334180/nitric-oxide-dependent-degradation-of-polyethylene-glycol-modified-single-walled-carbon-nanotubes-implications-for-intra-articular-delivery
#1
Kunal Bhattacharya, Cristiano Sacchetti, Pedro M Costa, Jens Sommertune, Birgit D Brandner, Andrea Magrini, Nicola Rosato, Nunzio Bottini, Massimo Bottini, Bengt Fadeel
Polyethylene glycol (PEG)-modified carbon nanotubes have been successfully employed for intra-articular delivery in mice without systemic or local toxicity. However, the fate of the delivery system itself remains to be understood. In this study 2 kDa PEG-modified single-walled carbon nanotubes (PNTs) are synthesized, and trafficking and degradation following intra-articular injection into the knee-joint of healthy mice are studied. Using confocal Raman microspectroscopy, PNTs can be imaged in the knee-joint and are found to either egress from the synovial cavity or undergo biodegradation over a period of 3 weeks...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29329028/equine-allogeneic-chondrogenic-induced-mesenchymal-stem-cells-a-gcp-target-animal-safety-and-biodistribution-study
#2
S Y Broeckx, J H Spaas, K Chiers, L Duchateau, L Van Hecke, L Van Brantegem, M Dumoulin, A M Martens, F Pille
The safety of the intra-articular use of mesenchymal stem cells (MSCs) is scarcely reported. Therefore, the goal of this study was to investigate the safety of a single intra-articular injection with allogeneic chondrogenic induced MSCs combined with equine plasma (=the investigational product: IVP) compared to a saline (0.9% NaCl) placebo control (=control product: CP). Sixteen healthy experimental horses were randomly assigned to receive a single intra-articular injection with either the IVP (n=8) or the CP (n=8) in the left metacarpophalangeal joint...
December 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29321825/umbilical-cord-blood-stem-cell-treatment-for-a-patient-with-psoriatic-arthritis
#3
Margaret Coutts, Rowena Soriano, Rajendran Naidoo, Habib Torfi
Clinical and laboratory results document psoriatic arthritis in a 56-year old patient. The symptoms did not resolve with standard treatments (nonsteroidal anti-inflammatory drugs, steroids and methotrexate). TNF-alpha inhibitors (certolizumab pegol and adalimumab) were added to the treatment regime, with some adverse effects. A trial of human umbilical cord stem cell therapy was then initiated. The stem cells were enriched and concentrated from whole cord blood, by removal of erythrocytes and centrifugation...
December 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/29320549/assessing-adverse-effects-of-intra-articular-botulinum-toxin-a-in-healthy-beagle-dogs-a-placebo-controlled-blinded-randomized-trial
#4
Helka M Heikkilä, Tarja S Jokinen, Pernilla Syrjä, Jouni Junnila, Anna Hielm-Björkman, Outi Laitinen-Vapaavuori
OBJECTIVE: To investigate the clinical, cytological, and histopathological adverse effects of intra-articularly injected botulinum toxin A in dogs and to study whether the toxin spreads from the joint after the injection. METHODS: A longitudinal, placebo-controlled, randomized clinical trial was conducted with six healthy laboratory Beagle dogs. Stifle joints were randomized to receive either 30 IU of onabotulinum toxin A or placebo in a 1:1 ratio. Adverse effects and spread of the toxin were examined by evaluating dynamic and static weight-bearing of the injected limbs, by assessing painless range of motion and pain on palpation of joints, and by performing synovial fluid analysis, neurological examination, and electrophysiological recordings at different examination time-points in a 12-week period after the injections...
2018: PloS One
https://www.readbyqxmd.com/read/29319609/joint-nociceptor-nerve-activity-and-pain-in-an-animal-model-of-acute-gout-and-its-modulation-by-intra-articular-hyaluronan
#5
Aida Marcotti, Ana Miralles, Eduardo Dominguez, Eliseo Pascual, Ana Gomis, Carlos Belmonte, Elvira de la Peña
The mechanisms whereby monosodium urate (MSU) crystals deposition in gout activate nociceptors to induce joint pain are incompletely understood. We tried to reproduce the signs of painful gouty arthritis, injecting into the knee joint of rats suspensions containing amorphous or triclinic, needle MSU crystals. The magnitude of MSU-induced inflammation and pain behavior signs was correlated with the changes in firing frequency of spontaneous and movement-evoked nerve impulse activity recorded in single knee joint nociceptor saphenous nerve fibers...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29318429/effect-of-intra-articular-injection-of-intermediate-weight-hyaluronic-acid-on-hip-and-knee-cartilage-in-vivo-evaluation-using-t2-mapping
#6
Giulio Ferrero, Luca Maria Sconfienza, Francesco Fiz, Emanuele Fabbro, Angelo Corazza, Daniele Dettore, Davide Orlandi, Carlo Castellazzo, Stefano Tornago, Giovanni Serafini
OBJECTIVES: We used T2 mapping to quantify the effect of intra-articular hyaluronic acid administration (IAHAA) on cartilage with correlation to clinical symptoms. METHODS: One hundred two patients with clinical and MRI diagnosis of hip or knee grade I-III chondropathy were prospectively included. All patients received a standard MRI examination of the affected hip/knee (one joint/patient) and T2-mapping multiecho sequence for cartilage evaluation. T2 values of all slices were averaged and used for analysis...
January 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29317799/intra-articular-collagenase-injection-increases-range-of-motion-in-a-rat-knee-flexion-contracture-model
#7
Kayleigh Wong, Guy Trudel, Odette Laneuville
Objectives: A knee joint contracture, a loss in passive range of motion (ROM), can be caused by prolonged immobility. In a rat knee immobilization flexion contracture model, the posterior capsule was shown to contribute to an irreversible limitation in ROM, and collagen pathways were identified as differentially expressed over the development of a contracture. Collagenases purified from Clostridium histolyticum are currently prescribed to treat Dupuytren's and Peyronie's contractures due to their ability to degrade collagen...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29311503/a-rat-model-of-knee-osteoarthritis-suitable-for-electroacupuncture-study
#8
Yongyuan Ma, Haiyun Guo, Fuhai Bai, Ming Zhang, Liu Yang, Jiao Deng, Lize Xiong
Acupuncture is widely used for knee osteoarthritis (KOA) treatment in clinical practice. In the present study, we aimed to set a standard KOA animal model for electroacupuncture (EA) study and provide an acupuncture recipe for further KOA studies. Rats intra-articularly administered monosodium iodoacetate (MIA, 0.3, 1 or 3 mg respectively, n=12 each) were evaluated for pain-like behavior: paw withdrawal mechanical threshold, weight bearing deficit, and joint pathological changes (OARSI score) until 28 days after injury...
January 1, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29306764/treatment-strategy-for-sacroiliac-joint-related-pain-at-or-around-the-posterior-superior-iliac-spine
#9
Eiichi Murakami, Daisuke Kurosawa, Toshimi Aizawa
OBJECTIVE: Pain at or around the posterior superior iliac spine (PSIS) is characteristic of sacroiliac joint (SIJ) -related pain. This pain can be treated by either a peri- or intra-articular injection into the joint, with the former being much easier to perform. We investigated whether peri- or intra-articular injections were more frequently effective in patients with SIJ-related pain, and aimed to create an efficient treatment strategy for SIJ-related pain at or around the PSIS. DESIGN: Prospective case-control study...
December 21, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29305995/acute-septic-arthritis-of-the-knee-a-rare-case-report-of-infection-with-parvimonas-micra-after-an-intra-articular-corticosteroid-injection-for-osteoarthritis
#10
Assem A Sultan, William A Cantrell, Anton Khlopas, Connor Cole, Nicolas S Piuzzi, Nipun Sodhi, Peter Brooks, Michael A Mont
Acute bacterial mono-articular septic arthritis affects most commonly the lower extremity joints in adult population and most commonly caused by Staphylococcus aureus. Various risk factors determine susceptibility to infection including host immunity, medical co-morbidity and joint structural abnormality and other organisms may be involved. Parvimonas micra (P. micra) is among the rare organisms that may be associated with atypical septic arthritis and primarily affects the native knee joint. Only 3 case reports in the literature have reported on pyogenic pyogenic joint infection caused by this organism...
January 3, 2018: Anaerobe
https://www.readbyqxmd.com/read/29300716/anti-osteoarthritic-and-anti-inflammatory-activities-of-diazine-in-vitro-and-in-vivo-studies
#11
Binjie Gui, Jinling Zhang, Sisheng Wang, Genxiang Rong
BACKGROUND The present study evaluated the effects of diazine (DZN) on collagenase-induced osteoarthritis (OA) in rats. MATERIAL AND METHODS OA was produced via intra-articular injections of collagenase type II into the knee joint. The rats were then treated with DZN (25, 50, or 100 mg/kg, p.o.) for three weeks. At the end of the protocol, all rats were evaluated for paw latency, paw edema, and knee swelling. Additionally, serum concentrations of glycosaminoglycan (GAG), alkaline phosphatase (ALP), and C-reactive protein (CRP) were determined...
January 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29287105/effect-of-intra-articular-administration-of-superparamagnetic-iron-oxide-nanoparticles-spions-for-mri-assessment-of-the-cartilage-barrier-in-a-large-animal-model
#12
Raphael Labens, Carola Daniel, Sarah Hall, Xin-Rui Xia, Tobias Schwarz
Early diagnosis of cartilage disease at a time when changes are limited to depletion of extracellular matrix components represents an important diagnostic target to reduce patient morbidity. This report is to present proof of concept for nanoparticle dependent cartilage barrier imaging in a large animal model including the use of clinical magnetic resonance imaging (MRI). Conditioned (following matrix depletion) and unconditioned porcine metacarpophalangeal cartilage was evaluated on the basis of fluorophore conjugated 30 nm and 80 nm spherical gold nanoparticle permeation and multiphoton laser scanning and bright field microscopy after autometallographic particle enhancement...
2017: PloS One
https://www.readbyqxmd.com/read/29279807/an-autologous-anti-inflammatory-protein-solution-yielded-a-favorable-safety-profile-and-significant-pain-relief-in-an-open-label-pilot-study-of-patients-with-osteoarthritis
#13
Jason Hix, Mark Klaassen, Ryan Foreman, Edith Cullen, Krista Toler, William King, Jennifer Woodell-May
Osteoarthritis (OA) is a progressive and degenerative disease, which may result in significant pain and decreased quality of life. Recent updates in our understanding of OA have demonstrated that it is a whole joint disease that has many similarities to an unhealed wound containing inflammatory cytokines. The nSTRIDE Autologous Protein Solution (APS) Kit is a medical device under development for the treatment of OA. The APS Kit processes a patient's own blood at the point of care to contain high concentrations of anti-inflammatory cytokines and anabolic growth factors...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29274196/musculoskeletal-ultrasound-for-intra-articular-bleed-detection-a-highly-sensitive-imaging-modality-compared-to-conventional-magnetic-resonance-imaging
#14
S Nguyen, X Lu, Y Ma, J Du, E Y Chang, A von Drygalski
BACKGROUND: There is increasing demand for musculoskeletal ultrasound (MSKUS) to detect hemophilic joint bleeding, but there is uncertainty regarding blood detection concentration thresholds or if magnetic resonance imaging (MRI) is more accurate. AIMS: Compare the sensitivity of blood detection by MSKUS and MRI. METHODS: Increasing blood concentrations in plasma were imaged with MSKUS and MRI 1-2 hours, 3-4 days and 7 days after blood withdrawal in vitro, and after injection into cadaveric pig joints...
December 23, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29273079/united-kingdom-frozen-shoulder-trial-uk-frost-multi-centre-randomised-12-month-parallel-group-superiority-study-to-compare-the-clinical-and-cost-effectiveness-of-early-structured-physiotherapy-versus-manipulation-under-anaesthesia-versus-arthroscopic-capsular
#15
Stephen Brealey, Alison L Armstrong, Andrew Brooksbank, Andrew Jonathan Carr, Charalambos P Charalambous, Cushla Cooper, Belen Corbacho, Joseph Dias, Iona Donnelly, Lorna Goodchild, Catherine Hewitt, Ada Keding, Lucksy Kottam, Sarah E Lamb, Catriona McDaid, Matthew Northgraves, Gerry Richardson, Sara Rodgers, Sarwat Shah, Emma Sharp, Sally Spencer, David Torgerson, Francine Toye, Amar Rangan
BACKGROUND: Frozen shoulder (also known as adhesive capsulitis) occurs when the capsule, or the soft tissue envelope around the ball and socket shoulder joint, becomes scarred and contracted, making the shoulder tight, painful and stiff. It affects around 1 in 12 men and 1 in 10 women of working age. Although this condition can settle with time (typically taking 1 to 3 years), for some people it causes severe symptoms and needs referral to hospital. Our aim is to evaluate the clinical and cost-effectiveness of two invasive and costly surgical interventions that are commonly used in secondary care in the National Health Service (NHS) compared with a non-surgical comparator of Early Structured Physiotherapy...
December 22, 2017: Trials
https://www.readbyqxmd.com/read/29246530/controversies-in-rheumatoid-arthritis-glucocorticoid-therapy
#16
Adeline Ruyssen-Witrand, Arnaud Constantin
Despite therapeutic innovations in the past 20 years, glucocorticoids (GC) are still widely used for the symptomatic treatment of rheumatoid arthritis (RA). Studies have demonstrated the clinical and structural efficacy of moderate doses (i.e. 30-60 mg/d) GC in addition to disease modifying anti-rheumatic drug (DMARD) initiation in early RA. A combination of a low dose of GC (i.e. 7.5-10 mg/d) and DMARDs increases remission rates and decreases the risk of medium-term structural progression in early RA. Intravenous and intramuscular administration of GC associated with DMARD initiation or intra-articular GC injections in symptomatic joints in tight control strategies increase remission rates in early RA...
December 12, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29245352/effect-of-multiple-intra-articular-injections-of-polynucleotides-on-treatment-of-intractable-knee-osteoarthritis-a-case-report
#17
Jong-Uk Mun, Hyung Rae Cho, Young Soon Choi, Young Uk Kim
RATIONALE: Knee osteoarthritis (KOA) is a chronic joint degenerative disease. Intra-articular injection (IAI) of hyaluronic acid (HA) is widely used to treat KOA. However, some HA injections have no effect at all. Polynucleotides (PN) are recently noted as a valid substitute for HA. PATIENT CONCERNS: A 61-year-old female was admitted to the pain center with symptoms of pain over the knee and warmth feeling with stiffness in the left knee. The patient reported chronic severe pain in the left knee area despite 6 times IAI of HA...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29244893/effectiveness-of-intra-articular-injections-of-sodium-hyaluronate-or-corticosteroids-for-intracapsular-temporomandibular-disorders-a-systematic-review-and-meta-analysis
#18
Marlon A Moldez, Victor R Camones, Guillermo E Ramos, Mariela Padilla, Reyes Enciso
AIMS: To assess the effectiveness of intra-articular injections of sodium hyaluronate (NaH) or corticosteroids (CS) for treatment of intracapsular temporomandibular disorders (TMD). METHODS: Single- or double-blinded randomized controlled trials (RCTs) on the effectiveness of NaH or CS injections, compared to each other or to placebo, for the treatment of intracapsular TMD due to osteoarthritis and/or internal joint derangement were analyzed in this systematic review and meta-analysis...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29243283/intra-articular-injection-of-autologous-adipose-derived-mesenchymal-stem-cells-in-treatment-of-knee-osteoarthritis
#19
Duško Spasovski, Vesna Spasovski, Zoran Baščarević, Maja Stojiljković, Miša Vreća, Marina Andjelković, Sonja Pavlović
BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disease, considered to be the fourth leading cause of disability and the second cause of inability to work in men. Recently, adipose derived mesenchymal stem cells (AD-MSCs) came in focus of regenerative medicine as promising tool for treatment of OA. It has been shown that administration of stem cells into impaired joints results in pain relief and improves quality of life, accompanied with restoration of hyaline articular cartilage...
December 15, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29231159/facet-joint-injections-for-non-specific-low-back-pain-a-feasibility-rct
#20
Saowarat Snidvongs, Rod S Taylor, Alia Ahmad, Simon Thomson, Manohar Sharma, Angela Farr, Deborah Fitzsimmons, Stephanie Poulton, Vivek Mehta, Richard Langford
BACKGROUND: Pain of lumbar facet-joint origin is a common cause of low back pain in adults and may lead to chronic pain and disability, with associated health and socioeconomic implications. The socioeconomic burden includes an inability to return to work resulting in loss of productivity in addition to direct and indirect health-care utilisation costs. Lumbar facet-joints are paired synovial joints between the superior and inferior articular processes of consecutive lumbar vertebrae and between the fifth lumbar vertebra and the sacrum...
December 2017: Health Technology Assessment: HTA
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