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Intra articular joint injection

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https://www.readbyqxmd.com/read/28209481/botulinum-toxin-type-a-reduces-inflammatory-hypernociception-induced-by-arthritis-in-the-temporomadibular-joint-of-rats
#1
Victor Ricardo Manuel Muñoz Lora, Juliana Trindade Clemente-Napimoga, Henrique Ballassini Abdalla, Cristina Gomes Macedo, Giancarlo de la Torre Canales, Celia Marissa Rizzatti Barbosa
OBJECTIVE: This study aimed to investigate the antinociceptive effects of Botulinum toxin type A (BoNT-A) on persistent inflammatory hypernociception induced by arthritis in the temporomandibular joint (TMJ) of rats. MATERIAL AND METHODS: Wistar rats were induced to persistent inflammatory hypernociception in the left TMJ. Then, animals were treated with intra-TMJ injections of BoNT-A, using doses of 3.5, 7 and 14 U/kg. Saline was used as control group. Behavioral tests were applied to evaluated the effect of BoNT-A in the inflammatory hypernociception...
February 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28203597/intra-articular-implantation-of-mesenchymal-stem-cells-part-1-a-review-of-the-literature-for-prevention-of-postmeniscectomy-osteoarthritis
#2
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Osteoarthritis (OA) after a partial or total meniscectomy procedure is a common pathology. Because of the high incidence of meniscectomy in the general population, as well as the significant burden of knee OA, there is increasing interest in determining methods for delaying postmeniscectomy OA. Biological therapies, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), have been proposed as possible therapies that could delay OA in this and other settings...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28203596/intra-articular-implantation-of-mesenchymal-stem-cells-part-2-a-review-of-the-literature-for-meniscal-regeneration
#3
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Knee osteoarthritis (OA) after partial or total meniscectomy is a prevalent issue that patients must face. Various methods of replacing meniscal tissue have been studied to avoid this progression, including meniscal allograft transplantation, meniscal scaffolds, and synthetic meniscus replacement. Studies have shown that meniscal scaffolds may improve symptoms but have not been shown to prevent progression of OA. Recently, mesenchymal stem cells (MSCs) have been proposed as a possible biological therapy for meniscal regeneration...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28194878/platelet-activated-serum-might-have-a-therapeutic-effect-on-damaged-articular-cartilage
#4
Munetaka Yokoyama, Masato Sato, Yoshiki Tani, Miyuki Yokoyama, Mami Kokubo, Masayuki Yamato, Teruo Okano, Joji Mochida
Platelet-activated serum (PAS) was collected from rabbits. This contains high concentrations of growth factors, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)-BB, and transforming growth factor-beta (TGF-β). PAS was injected into the knee joints of Japanese White rabbits subjected to anterior cruciate ligament transection (ACL-T) to investigate its therapeutic effects on articular cartilage. The effect of Avastin (an anti-VEGF monoclonal antibody) on VEGF expression was also investigated...
February 14, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28192374/transcription-factor-nfat5-promotes-macrophage-survival-in-rheumatoid-arthritis
#5
Susanna Choi, Sungyong You, Donghyun Kim, Soo Youn Choi, H Moo Kwon, Hyun-Sook Kim, Daehee Hwang, Yune-Jung Park, Chul-Soo Cho, Wan-Uk Kim
Defective apoptotic death of activated macrophages has been implicated in the pathogenesis of rheumatoid arthritis (RA). However, the molecular signatures defining apoptotic resistance of RA macrophages are not fully understood. Here, global transcriptome profiling of RA macrophages revealed that the osmoprotective transcription factor nuclear factor of activated T cells 5 (NFAT5) critically regulates diverse pathologic processes in synovial macrophages including the cell cycle, apoptosis, and proliferation...
February 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28162781/intra-articular-corticosteroids-versus-intra-articular-corticosteroids-plus-methotrexate-in-oligoarticular-juvenile-idiopathic-arthritis-a-multicentre-prospective-randomised-open-label-trial
#6
Angelo Ravelli, Sergio Davì, Giulia Bracciolini, Angela Pistorio, Alessandro Consolaro, Evert Hendrik Pieter van Dijkhuizen, Bianca Lattanzi, Giovanni Filocamo, Sara Verazza, Valeria Gerloni, Maurizio Gattinara, Irene Pontikaki, Antonella Insalaco, Fabrizio De Benedetti, Adele Civino, Giuseppe Presta, Luciana Breda, Valentina Marzetti, Serena Pastore, Silvia Magni-Manzoni, Maria Cristina Maggio, Franco Garofalo, Donato Rigante, Marco Gattorno, Clara Malattia, Paolo Picco, Stefania Viola, Stefano Lanni, Nicolino Ruperto, Alberto Martini
BACKGROUND: Little evidence-based information is available to guide the treatment of oligoarticular juvenile idiopathic arthritis. We aimed to investigate whether oral methotrexate increases the efficacy of intra-articular corticosteroid therapy. METHODS: We did this prospective, open-label, randomised trial at ten hospitals in Italy. Using a concealed computer-generated list, children younger than 18 years with oligoarticular-onset disease were randomly assigned (1:1) to intra-articular corticosteroids alone or in combination with oral methotrexate (15 mg/m(2); maximum 20 mg)...
February 2, 2017: Lancet
https://www.readbyqxmd.com/read/28146402/a-multicenter-study-of-early-anti-inflammatory-treatment-in-patients-with-acute-anterior-cruciate-ligament-tear
#7
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Laura J Huston, Lee G Gammon, Darren L Johnson, Emily K Reinke, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression from anterior cruciate ligament (ACL) injury to PTOA is multifactorial, involving the interplay between biomechanical disturbances and biochemical homeostasis of articular cartilage. PURPOSE: The purposes of this randomized study using an acute ACL injury model were to (1) evaluate the natural progression of inflammatory and chondrodegenerative biomarkers, (2) evaluate the relationship between subjective reports of pain and inflammatory and chondrodegenerative biomarkers, and (3) determine if postinjury arthrocentesis and corticosteroid injection offer the ability to alter this biochemical cascade...
February 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28139016/a-human-blood-based-anti-inflammatory-solution-inhibits-osteoarthritis-progression-in-a-meniscal-tear-rat-study
#8
William King, Alison Bendele, Taylor Marohl, Jennifer Woodell-May
Current osteoarthritis (OA) research searches for treatments that modify the course of disease progression. Autologous Protein Solution (APS) is derived from whole blood and is a unique autologous therapy that contains high concentrations of white blood cells, platelets, and concentrated plasma, providing cytokines that can target the underlying mechanisms of disease progression. The APS Kit is currently under investigation for clinical use in the USA (NCT02262364). The aim of this study was to determine if APS has disease-modifying properties in the well-characterized rat meniscal tear-induced model of OA...
January 31, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28129516/intra-articular-recombinant-human-proteoglycan-4-mitigates-cartilage-damage-after-destabilization-of-the-medial-meniscus-in-the-yucatan-minipig
#9
Kimberly A Waller, Kaitlyn E Chin, Gregory D Jay, Ling X Zhang, Erin Teeple, Scott McAllister, Gary J Badger, Tannin A Schmidt, Braden C Fleming
BACKGROUND: Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint boundary lubrication. PRG4 has been shown previously to be down-regulated after traumatic joint injury such as a meniscal tear. Preliminary evidence suggests that intra-articular injection of PRG4 after injury will reduce cartilage damage in rat models of surgically induced posttraumatic osteoarthritis. OBJECTIVE: To determine the efficacy of intra-articular injection of full-length recombinant human lubricin (rhPRG4) for reducing cartilage damage after medial meniscal destabilization (DMM) in a preclinical large animal model...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28129509/diagnostic-accuracy-of-imaging-modalities-and-injection-techniques-for-the-diagnosis-of-femoroacetabular-impingement-labral-tear
#10
Michael P Reiman, Kristian Thorborg, Adam P Goode, Chad E Cook, Adam Weir, Per Hölmich
BACKGROUND: Diagnosing femoroacetabular impingement/acetabular labral tear (FAI/ALT) and subsequently making a decision regarding surgery are based primarily on diagnostic imaging and intra-articular hip joint injection techniques of unknown accuracy. PURPOSE: Summarize and evaluate the diagnostic accuracy and clinical utility of various imaging modalities and injection techniques relevant to hip FAI/ALT. STUDY DESIGN: Systematic review with meta-analysis...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28119772/fluoroscopy-guided-intra-articular-steroid-injection-for-sternoclavicular-joint-arthritis-secondary-to-limited-cutaneous-systemic-sclerosis-a-case-report
#11
Savas Sencan, Emel Güler, Isa Cüce, Kemal Erol
We report a case of fluoroscopy-guided intraarticular steroid injection for sternoclavicular joint (SCJ) arthritis caused by limited cutaneous systemic sclerosis (SSc). A 50-year-old woman diagnosed with limited cutaneous SSc presented with swelling and pain in the right SCJ. MRI revealed signs of inflammation consistent with right-sided sternoclavicular joint arthritis. After the failure of oral medications, we performed fluoroscopy-guided injection in this region. She reported complete resolution of her symptoms at 4 and 12-week follow-ups...
January 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28117560/pharmacokinetics-of-betamethasone-in-plasma-urine-and-synovial-fluid-following-intra-articular-administration-to-exercised-thoroughbred-horses
#12
Heather K Knych, Scott D Stanley, Linda M Harrison, Daniel S McKemie
The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racing fit adult Thoroughbred horses received a single intra-articular administration (9 mg) of a betamethasone sodium phosphate & betamethasone acetate injectable suspension into the right antebrachiocarpal joint...
January 24, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28108560/cxcr3-cxcl10-axis-regulates-neutrophil-nk-cell-cross-talk-determining-the-severity-of-experimental-osteoarthritis
#13
Giorgia Benigni, Petya Dimitrova, Fabrizio Antonangeli, Emilio Sanseviero, Viktoriya Milanova, Arjen Blom, Peter van Lent, Stefania Morrone, Angela Santoni, Giovanni Bernardini
Several immune cell populations are involved in cartilage damage, bone erosion, and resorption processes during osteoarthritis. The purpose of this study was to investigate the role of NK cells in the pathogenesis of experimental osteoarthritis and whether and how neutrophils can regulate their synovial localization in the disease. Experimental osteoarthritis was elicited by intra-articular injection of collagenase in wild type and Cxcr3(-/-) 8-wk old mice. To follow osteoarthritis progression, cartilage damage, synovial thickening, and osteophyte formation were measured histologically...
January 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28106925/clinical-study-evaluating-the-accuracy-of-injecting-the-distal-tarsal-joints-in-the-horse
#14
K A Seabaugh, K T Selberg, P O E Mueller, R B Eggleston, J F Peroni, K M Claunch, H J Markwell, G M Baxter
BACKGROUND: Osteoarthritis (OA) of the centrodistal (CD) and tarsometatarsal (TMT) joints is a common cause of lameness in horses. Intra-articular diagnostic anaesthesia and/or therapeutic injection are relied upon to help diagnose and treat many horses with OA of these joints. OBJECTIVES: The objective of this study was to determine the accuracy of arthrocentesis of the CD and TMT joints using a sample population of equine surgeons and surgery residents. STUDY DESIGN: Randomised experimental study...
January 20, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28100866/development-of-intra-knee-joint-sustained-release-gel-formulation-and-evaluation-of-its-pharmacological-efficiency-in-rats
#15
Takehiro Noda, Tomoyuki Okuda, Kousuke Ban, Ryota Mizuno, Tatsuaki Tagami, Tetsuya Ozeki, Hirokazu Okamoto
In the development of a drug for intra-articular administration, a sustained-release formulation is desirable since it is difficult to sustain the effects of conventional injections due to fast drug leakage from the joint cavity. In this study, we prepared sustained release gel formulations for intra-articular administration containing indocyanine green (ICG) as a model drug to follow its fate after intra-articular administration in rats with IVIS. ICG administered as an aqueous solution leaked from the joint cavity in a short time and was excreted out of the body within a day...
January 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28094412/ultrasound-guided-approach-to-the-cervical-articular-process-joints-in-horses-a-validation-of-the-technique-in-cadavers
#16
Jessica Purefoy Johnson, John David Stack, Conor Rowan, Ian Handel, John Mark O'Leary
OBJECTIVES: To compare accuracy of the ultrasound-guided craniodorsal (CrD) approach with the dorsal (D) approach to the cervical articular process joints, and to evaluate the effect of transducer, needle gauge, and operator experience. METHODS: Cervical articular process joints from 14 cadaveric neck specimens were injected using either a D or CrD approach, a linear (13 MHx) or microconvex transducer (10 MHz), and an 18 or 20 gauge needle, by an experienced or inexperienced operator...
January 17, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28088207/cytokine-and-neuropeptide-levels-are-associated-with-pain-relief-in-patients-with-chronically-painful-total-knee-arthroplasty-a-pilot-study
#17
Jasvinder A Singh, Siamak Noorbaloochi, Keith L Knutson
BACKGROUND: There are few studies with an assessment of the levels of cytokines or neuropeptides as correlates of pain and pain relief in patients with painful joint diseases. Our objective was to assess whether improvements from baseline to 2-months in serum cytokine, chemokine and substance P levels were associated with clinically meaningful pain relief at 2-months post-injection in patients with painful total knee arthroplasty (TKA). METHODS: Using data from randomized trial of 60 TKAs, we assessed the association of change in cytokine/chemokine/Substance P levels with primary study outcome, clinically important improvement in Western Ontario McMaster Osteoarthritis Index (WOMAC) pain subscale at 2-months post-injection using Student's t-tests and Spearman's correlation coefficient (non-parametric)...
January 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28066733/viscosupplementation-with-intra-articular-hyaluronic-acid-for-hip-disorders-a-systematic-review-and-meta-analysis
#18
Eleonora Piccirilli, Francesco Oliva, Mihaela Aconstantinesei Murè, Asmaa Mahmoud, Calogero Foti, Umberto Tarantino, Nicola Maffulli
BACKGROUND: Hip joint diseases are common in adult population and their prevalence increases with age. Osteoarthritis, rheumatoid arthritis and femoroacetabular impingement are the most common chronic diseases in the hip joint. Viscosupplementation with exogenous hyaluronic acid (HA) is one of the most widely used conservative treatment aiming to improve synovial fluid properties and to decrease pain. There is no global consensus on the type of HA, method of injection and frequency, or on its efficacy in hip joint...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28065216/expression-of-mirna-140-in-chondrocytes-and-synovial-fluid-of-knee-joints-in-patients-with-osteoarthritis
#19
Si Hai-Bo, Zeng Yi, Zhou Zong-Ke, Pei Fu-Xing, Lu Yan-Rong, Cheng Jing-Qiu, Shen Bin
Objective To investigate the expression of miRNA-140 in chondrocytes and synovial fluid of osteoarthritis (OA) patients, and explore the relationship between the miRNA-140 expression and OA severity.Methods This study enrolled 30 OA patients who underwent total knee arthroplasty for chondrocytes sampling and 30 OA patients who underwent intra-articular injection for synovial fluid sampling. All OA patients were grouped into mild [Kellgren and Lawrence (KL) grade 1-2], moderate (KL grade 3) and severe (KL grade 4), with 10 in each subgroups for each sampling purposes...
November 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28059868/a-novel-inhibitor-of-active-protein-kinase-g-attenuates-chronic-inflammatory-and-osteoarthritic-pain
#20
Ying-Ju Sung, Nelson Sofoluke, Mary Nkamany, Shixian Deng, Yuli Xie, Jeremy Greenwood, Ramy Farid, Donald W Landry, Richard T Ambron
Activating Protein kinase-1α (PKG-1α) induces a long-term hyperexcitability (LTH) in nociceptive neurons. Since the LTH correlates directly with chronic pain in many animal models we tested the hypothesis that inhibiting PKG-1α would attenuate LTH-mediated pain. We first synthesized and characterized compound N46 (propoxybenzoyl)benzamidopyrrolidin-3-yl)-1H-indazole-5-carboxamide). N46 inhibits PKG-1α with an IC50 of 7.5nmol, was highly selective when tested against a panel of 274 kinases, and tissue distribution studies indicate that it does not enter the CNS...
December 30, 2016: Pain
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