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Monosodium urate crystal

Alexis Ogdie, William J Taylor, Tuhina Neogi, Jaap Fransen, Tim L Jansen, H Ralph Schumacher, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Maxim Eliseev, Geraldine McCarthy, Lisa K Stamp, Fernando Perez-Ruiz, Francisca Sivera, Hang-Korng Ea, Martijn Gerritsen, Giovanni Cagnotto, Lorenzo Cavagna, Chingtsai Lin, Yin-Yi Chou, Anne-Kathrin Tausche, Manuella Lima Gomes Ochtrop, Matthijs Janssen, Jiunn-Horng Chen, Ole Slot, Juris Lazovskis, Douglas White, Marco A Cimmino, Till Uhlig, Nicola Dalbeth
OBJECTIVES: To examine the performance of ultrasound for the diagnosis of gout using presence of monosodium urate (MSU) crystals as the gold standard. METHODS: We analyzed data from the Study for Updated Gout Classification Criteria (SUGAR), a large, multi-center observational cross-sectional study of consecutive subjects with at least one swollen joint who conceivably may have gout. All subjects underwent arthrocentesis; cases were subjects with MSU crystal confirmation...
October 16, 2016: Arthritis & Rheumatology
Yeon-Ho Chung, Dong-Hyun Kim, Won-Woo Lee
IL-1β is a key mediator of sterile inflammation in response to endogenous particulates, a type of damage-associated molecular pattern (DAMPs) molecule derived from damaged cells. Despite the well-known role of sterile particulates such as monosodium urate (MSU) crystals as inflammasome inducers in monocytes/macrophages, little is known regarding how pro-IL-1β synthesis is induced under sterile inflammatory conditions. We provide evidence that MSU crystals post-transcriptionally induce the rapid production of pro-IL-1β in human primary monocytes...
October 3, 2016: Scientific Reports
B Udhaya Lavinya, Ishita Bardhan, Sabina Evan Prince
Gout is a type of arthritis, which could result from the deposition of monosodium urate crystals in joints. It can cause redness, burning pain, inflammation of joints especially in big toe. In this study, we have looked for anti-arthritic effect of coenzyme Q10 (CoQ10) on monosodium urate crystal-induced inflammation in rats and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin. The evaluation was done by measuring the paw volume, antioxidant status, lipid peroxidation, lysosomal enzymes (β-glcuronidase, β-galactosidase, N-acetyl-β-d-glucosaminidase, acid phosphatase) activities and histopathological studies...
September 29, 2016: European Journal of Pharmacology
Ya-Fei Liu, Cai-Yu-Zhu Wen, Zhe Chen, Yu Wang, Ying Huang, Sheng-Hao Tu
Background. Urate crystals-induced inflammation is a critical factor during the initiation of gouty arthritis. Berberine is well known for its anti-inflammatory activity. However, the underlying effects of berberine on monosodium urate crystals-induced inflammation remain obscure. Objectives. This study is set to explore the protective effect and mechanism of berberine on monosodium urate crystals-induced inflammation in human monocytic THP-1 cells. Methods. The mRNA levels of NLRP3 and IL-1β were measured by Real-Time PCR, and the protein levels of NLRP3 and IL-1β were determined by ELISA, Western blot, and immunofluorescence...
2016: BioMed Research International
Chio Yokose, Meng Chen, Adey Berhanu, Michael H Pillinger, Svetlana Krasnokutsky
Osteoarthritis (OA), the most common type of arthritis worldwide, is a degenerative disease of diarthrodial joints resulting in pain, reduced quality of life, and socioeconomic burden. Gout, the most common form of inflammatory arthritis, is a consequence of persistently elevated levels of urate and the formation of proinflammatory monosodium urate crystals in joints. Clinicians have long noted a predilection for both diseases to occur in the same joints. In this review, we provide an overview into research elucidating possible biochemical, mechanical, and immunological relationships between gout and OA...
October 2016: Current Rheumatology Reports
Patapong Towiwat, Anthony J Doyle, Gregory D Gamble, Paul Tan, Opetaia Aati, Anne Horne, Lisa K Stamp, Nicola Dalbeth
BACKGROUND: It is currently unknown whether bone erosion in gout occurs through an 'inside-out' mechanism due to direct intra-osseous crystal deposition or through an 'outside-in' mechanism from the surface of bone. The aim of this study was to examine the mechanism ('outside-in' vs. 'inside-out') of monosodium urate (MSU) crystal deposition in bone erosion in gout. Specifically, we used three-dimensional dual-energy computed tomography (DECT) to analyse the positional relationship between bone and MSU crystal deposition in tophaceous gout, and to determine whether intra-osseous crystal deposition occurs in the absence of erosion...
2016: Arthritis Research & Therapy
Qiao Han, Wang Bing, Yin Di, Li Hua, Li Shi-He, Zheng Yu-Hua, Han Xiu-Guo, Wang Yu-Gang, Fan Qi-Ming, Yang Shih-Mo, Tang Ting-Ting
Gouty arthritis is a rheumatic disease that is characterized by the deposition of monosodium urate (MSU) in synovial joints cause by the increased serum hyperuricemia. This study used a three-dimensional (3D) flowing microfluidic chip to screen the effective candidate against MSU-stimulated human umbilical vein endothelial cell (HUVEC) damage, and found kinsenoside (Kin) to be the leading active component of Anoectochilus roxburghi, one of the Chinese medicinal plant widely used in the treatment of gouty arthritis clinically...
2016: Cell Death & Disease
Gary Ruoff, N Lawrence Edwards
Gout is a progressive, painful, debilitating form of inflammatory arthritis. It is caused by factors that elevate the concentration of serum uric acid (sUA), leading to hyperuricemia (sUA >6.8 mg/dL). Continued elevated sUA can result in monosodium urate (MSU) crystal deposition in joints and soft tissues, and can cause acute and chronic inflammation. The prevalence of hyperuricemia and gout has increased over the last few decades, likely due to an aging population, changes in lifestyles and diet, and an increase in gout-associated comorbidities...
September 2016: Postgraduate Medicine
Faith Li-Ann Chia
Gout, an inflammatory arthritis caused by the deposition of monosodium urate crystals, is commonly seen in primary care and specialist clinics. In recent years, there has been a resurgence of interest in gout due to advances in therapies and the understanding of pathophysiology, with new guidelines being published by international bodies. However, there is still a gap between the goals of treatment and actual day-to-day practice. Barriers that result in poorly controlled gout include patient factors such as lack of understanding of the disease, stigma and nonadherence to treatment, as well as physician factors such as knowledge gaps, inadequate use of allopurinol and lack of ownership of the disease...
August 2016: Singapore Medical Journal
Juhi Bagaitkar, Emilia A Barbu, Lizet J Perez-Zapata, Anthony Austin, Guangming Huang, Sabine Pallat, Mary C Dinauer
Mutations in the leukocyte NADPH oxidase that abrogate superoxide production result in chronic granulomatous disease (CGD), an inherited immunodeficiency associated with recurrent infections and inflammatory complications. The cytosolic regulatory subunit p40(phox) plays a specialized role in stimulating NADPH oxidase activity on intracellular membranes via its phosphatidylinositol 3-phosphate [PI(3)P]-binding domain, as revealed by studies largely focused on neutrophils. Whether PI(3)P-p40(phox)-regulated superoxide production contributes to regulating inflammatory responses is not well understood...
August 19, 2016: Journal of Leukocyte Biology
Isabel Andia, Michele Abate
Hyperuricemia, particularly gout, and the immune inflammatory response are highly integrated. Both, long standing hyperuricemia and monosodium urate (MSU) crystal deposition can challenge tendon homeostasis because of their potential to cause inflammation to the host. Knowledge is emerging from clinical imaging research depicting where MSU crystals deposit, including patellar tendon, triceps and quadriceps tendons. Remarkably, subclinical tendon inflammation and damage are also present in asymptomatic hyperuricemia...
2016: Advances in Experimental Medicine and Biology
Shyamashis Das, Alakendu Ghosh, Parasar Ghosh, Debasish Lahiri, Pradyot Sinhamahapatra, Kaushik Basu
AIM: This study aimed to assess the sensitivity and specificity of ultrasonographic features of gout in intercritical and chronic stages and compared ultrasonographic features of gout between patients with persistent high serum uric acid (SUA) and patients with low SUA. METHODS: Adult patients with gout confirmed by demonstration of monosodium urate crystals were recruited, if they were in intercritical or chronic stage clinically. Ultrasonographic examination of the first metatarsophalangeal joints (MTPJs) and the knee joints of both sides were done by a blinded rheumatologist trained in musculoskeletal ultrasound...
August 16, 2016: International Journal of Rheumatic Diseases
Angélica T Vieira, Izabela Galvão, Laurence M Macia, Érica M Sernaglia, Marco Aurélio R Vinolo, Cristiana C Garcia, Luciana P Tavares, Flávio A Amaral, Lirlândia P Sousa, Flaviano S Martins, Charles R Mackay, Mauro M Teixeira
: Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue damage. We investigated the effects of a high-fiber diet and acetate, a short-chain fatty acid (SCFA) resulting from the metabolism of fiber by gut microbiota, on the inflammatory response in an experimental model of gout in mice. Injection of MSU crystals into the knee joint of mice induced neutrophil influx and inflammatory hypernociception...
August 5, 2016: Journal of Leukocyte Biology
Shyamashis Das, Rudra Prosad Goswami, Alakendu Ghosh, Parasar Ghosh, Debasish Lahiri, Kaushik Basu
OBJECTIVE: To detect evolution of ultrasonographic signs of deposition of monosodium urate crystals (MSUC) in gouty joints by serial ultrasonography after initiation of urate-lowering therapy (ULT). METHODS: Adult gout patients were examined by serial ultrasonography after initiation of ULT with target serum uric acid (SUA) < 6 mg/dL. RESULTS: Thirty-eight male patients with gout with mean age of 50 ± 11 years, median disease duration of 48 months and baseline mean SUA level of 8...
August 5, 2016: Modern Rheumatology
Ahmet Mutlu, Emine Dündar, Mete İşeri, Cengiz Erçin, Ayşe Cefle
Gout is a common metabolic disease and is characterized by episodic acute and chronic arthritis caused by the deposition of monosodium urate (MSU) crystals in joints and connective tissues. The most commonly involved joint is the first metatarsophalangeal joint. It may also present with nonspecific complaints caused by gouty tophi in unusual sites of the body such as the spine, bone, and middle ear. Such involvements can be disabling and impair the quality of life. In this report, we describe the case of a patient who had complaints of hearing loss and otorrhea...
August 2016: Journal of International Advanced Otology
Randall N Beyl, Laura Hughes, Sarah Morgan
Gout is an inflammatory arthritis caused by deposition of monosodium urate crystals within synovial joints. Although it is most well-known for its arthritis, gout has an intimate relationship with many other cardiovascular and metabolic conditions. Current recommendations support aggressive medical therapy to treat gout while dietary counseling has become less emphasized. This article argues for the absolute importance of dietary counseling in gout and proves why this counseling may impact the long term well-being of a patient with gout...
July 21, 2016: American Journal of Medicine
Yi Wang, Chao Luo, Guang Yang, Xiao Wei, Dian Liu, Shaobing Zhou
The recurrence of acute gout attacks remains an unsolved problem in clinical therapy. In order to tackle this problem, poly(ε-caprolactone) (PCL)/gelatin composite fibrous devices loaded with luteolin are presented via electrospinning for the therapy of gout and its recurrence. The luteolin-loaded fibrous device has the capability of inhibiting metabolic activities and reducing inflammation-associated cytokine productions (TNF-a, IL-1β, IL-6) that are secreted by lipopolysaccharide stimulated RAW 264.7 macrophages...
July 22, 2016: Macromolecular Bioscience
Jieru Han, Ying Xie, Fangyu Sui, Chunhong Liu, Xiaowei Du, Chenggang Liu, Xiaoling Feng, Deyou Jiang
Based on traditional Chinese medicinal theories on gouty arthritis, Zisheng Shenqi decoction (ZSD), a novel Chinese medicinal formula, was developed due to its multiple functions, including reinforcing renal function, promoting blood circulation and relieving pain. In the present study, the effect of ZSD on monosodium urate (MSU) crystal-induced gouty arthritis in rats was investigated and the underlying mechanisms were examined. The data from these investigations showed that the injection of MSU crystals into the ankle joint cavity caused significant elevations in ankle swelling and inflammatory cell infiltration into the synovium, whereas these abnormal changes were markedly suppressed by oral administration of ZSD (40 mg/kg) for 7 days...
September 2016: Molecular Medicine Reports
Clare C Cunningham, Emma M Corr, Geraldine M McCarthy, Aisling Dunne
OBJECTIVE: Basic calcium phosphate (BCP) and monosodium urate (MSU) crystals are particulates with potent pro-inflammatory effects, associated with osteoarthritis (OA) and gout, respectively. Bone erosion, due to increased osteoclastogenesis, is a hallmark of both arthropathies and results in severe joint destruction. The aim of this study was to investigate the effect of these endogenous particulates on anti-osteoclastogenic cytokine signalling. METHODS: Human osteoclast precursors were treated with BCP and MSU crystals prior to stimulation with IL-6 or IFN-γ and the effect on STAT-3 and STAT-1 activation in addition to MAP kinase activation was examined by immunoblotting...
July 14, 2016: Osteoarthritis and Cartilage
Heidi Dahl Christensen, Hussam Mahmoud Sheta, Melanie Birger Morillon, Inger Marie Jensen Hansen
BACKGROUND Gout is characterized by deposition of uric acid crystals (monosodium urate) in tissues and fluids. This can cause acute inflammatory arthritis. The 2015 ACR/EULAR criteria for the diagnosis of gout include dual energy computed tomography (DECT)-demonstrated monosodium urate crystals as a new criterion. DECT is a spectral decomposition that permits recognition of different types of tissues based on their characteristic energy-dependent photon attenuation. A positive scan is defined as the presence of urate at articular or periarticular sites...
2016: American Journal of Case Reports
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