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https://www.readbyqxmd.com/read/29146745/response-to-use-of-urate-lowering-therapies-is-not-associated-with-an-increase-in-the-risk-of-incident-dementia-in-older-adults-by-lee-and-song
#1
Jasvinder A Singh, John Cleveland
No abstract text is available yet for this article.
November 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29146741/presence-of-monosodium-urate-crystal-deposition-by-dual-energy-ct-in-patients-with-gout-treated-with-allopurinol
#2
Nicola Dalbeth, Savvas Nicolaou, Scott Baumgartner, Jia Hu, Maple Fung, Hyon K Choi
OBJECTIVE: Dual-energy CT (DECT) detects and quantifies monosodium urate (MSU) crystal deposition with high precision. This DECT study assessed crystal deposition in patients with gout treated with stable-dose allopurinol, and investigated potential clinical determinants for crystal deposition. METHODS: Patients with gout treated with allopurinol ≥300 mg daily for at least 3 months were prospectively recruited from the USA and New Zealand, using monitored enrolment to include approximately 25% patients with palpable tophi and approximately 50% with serum urate (sUA) levels <6...
November 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29142418/marantodes-pumilum-blume-kuntze-inhibited-secretion-of-lipopolysaccharide-and-monosodium-urate-crystal-stimulated-cytokines-and-plasma-prostaglandin-e2
#3
Eldiza Puji Rahmi, Jamia Azdina Jamal, Endang Kumolosasi, Juriyati Jalil, Nor-Ashila Aladdin
Background: Marantodes pumilum is traditionally used for dysentery, gonorrhea, and sickness in the bones. Previous studies revealed its antibacterial and xanthine oxidase inhibitory activities. Objective: To evaluate the inhibitory effects of three M. pumilum varieties on the secretion of lipopolysaccharide (LPS)- and monosodium urate crystal (MSU)-induced cytokines and plasma prostaglandin E2 (PGE2) in vitro. Materials and Methods: The leaves and roots of M...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29140472/uric-acid-predicts-adverse-outcomes-in-chronic-kidney-disease-a-novel-insight-from-trajectory-analyses
#4
Ching-Wei Tsai, Hsien-Tsai Chiu, Han-Chun Huang, I-Wen Ting, Hung-Chieh Yeh, Chin-Chi Kuo
Background: Very little is known about longitudinal trajectories of serum uric acid (SUA) over the course of chronic kidney disease (CKD). We aimed to determine whether longitudinal SUA trajectories are associated with the risk of end-stage renal disease (ESRD) and all-cause mortality among CKD patients. Methods: We conducted a prospective cohort study from a 13-year multidisciplinary pre-ESRD care registry. The final study population consisted of 5090 CKD patients aged 20-90 years between 2003 and 2015...
November 10, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29138474/phagocytosis-of-environmental-or-metabolic-crystalline-particles-induces-cytotoxicity-by-triggering-necroptosis-across-a-broad-range-of-particle-size-and-shape
#5
Mohsen Honarpisheh, Orestes Foresto-Neto, Jyaysi Desai, Stefanie Steiger, Lidia Anguiano Gómez, Bastian Popper, Peter Boor, Hans-Joachim Anders, Shrikant R Mulay
In crystallopathies, crystals or crystalline particles of environmental and metabolic origin deposit within tissues, induce inflammation, injury and cell death and eventually lead to organ-failure. The NLRP3-inflammasome is involved in mediating crystalline particles-induced inflammation, but pathways leading to cell death are still unknown. Here, we have used broad range of intrinsic and extrinsic crystal- or crystalline particle-sizes and shapes, e.g. calcium phosphate, silica, titanium dioxide, cholesterol, calcium oxalate, and monosodium urate...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137059/adherence-to-gout-management-recommendations-of-chinese-patients
#6
Feng Sheng, Weigang Fang, Bingqing Zhang, Yue Sha, Xuejun Zeng
Though efficacious and affordable treatments for gout are widely available, gout is still not well controlled in many countries of the world including China.To investigate patient adherence to gout management recommendations and potential barriers in Chinese male gout patients, a survey was carried out by telephone interview in male patients registered in the gout clinic at Peking Union Medical College Hospital. Adherence to dietary and medication recommendations was measured by a food frequency questionnaire and proportion of cumulative time adherent to chemical urate-lowering therapy (ULT), respectively...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135148/-hemorrhagic-complications-of-percutaneous-interventions-for-nephrolithiasis
#7
S V Shkodkin, Yu B Idashkin, V N Dmitriev, A V Lyubushkin, A A Nevskii
Hemorrhagic complications are one of the major problems of percutaneous urolithiasis interventions. AIM: To investigate the incidence of hemorrhagic complications after percutaneous nephrolithotripsy. MATERIAL AND METHODS: This was a comparative analysis of 146 percutaneous nephrolithotripsies. The study group comprised 81 patients with stag horn nephrolithiasis; the rest of the patients were assigned to the control group. RESULTS: Both groups were comparable in age and sex (p>0...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29133496/factors-influencing-allopurinol-initiation-in-primary-care
#8
Lorna E Clarson, Samantha L Hider, John Belcher, Edward Roddy, Christian D Mallen
Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number of consultations, and meeting internationally agreed eligibility criteria on time to allopurinol initiation. Time to first prescription was modeled using multilevel Cox proportional hazards regression. Allopurinol initiation was positively associated with meeting eligibility criteria at diagnosis of gout, but negatively associated with becoming eligible after diagnosis...
November 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/29132945/uric-acid-and-the-risks-of-kidney-failure-and-death-in-individuals-with-ckd
#9
Anand Srivastava, Arnaud D Kaze, Ciaran J McMullan, Tamara Isakova, Sushrut S Waikar
BACKGROUND: Serum uric acid concentrations increase in chronic kidney disease (CKD) and may lead to tubular injury, endothelial dysfunction, oxidative stress, and intrarenal inflammation. Whether uric acid concentrations are associated with kidney failure and death in CKD is unknown. STUDY DESIGN: Prospective observational cohort study. SETTINGS & PARTICIPANTS: 3,885 individuals with CKD stages 2 to 4 enrolled in the Chronic Renal Insufficiency Cohort (CRIC) between June 2003 and September 2008 and followed up through March 2013...
November 10, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29132796/old-drug-new-indication-olsalazine-sodium-reduced-serum-uric-acid-levels-in-mice-via-inhibiting-xanthine-oxidoreductase-activity
#10
Yanfen Niu, Hongjian Li, Lihui Gao, Hua Lin, Hsiangfu Kung, Marie Chia-Mi Lin, Kwong-Sak Leung, Man-Hon Wong, Wenyong Xiong, Ling Li
Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Here we used the protein-ligand docking software idock to virtually screen potential XOD inhibitors from 3167 approved small compounds/drugs. The inhibitory activities of the ten compounds with the highest scores were tested on XOD in vitro...
October 31, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29123379/guideline-development-for-the-management-of-gout-role-of-combination-therapy-with-a-focus-on-lesinurad
#11
REVIEW
Graeme Jones, Elena Panova, Richard Day
The aim of this review was to summarize the evidence for combination therapy to achieve serum urate (SUA) target levels in gout. Within this overarching aim, a second aim was to evaluate the evidence for a new uricosuric agent lesinurad, which inhibits urate transport in the kidney. In summary, this review indicates that there are a number of ways to approach patients who do not achieve a target serum urate with allopurinol (APL) monotherapy. These include higher doses of APL up to 600-800 mg/d, switching to febuxostat, or adding in a uricosuric...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29119028/erosive-pustular-dermatosis-of-the-scalp-with-urate-like-crystals
#12
Patrick O Emanuel, Sharad P Paul
Follicular urate-like crystals were first described in Necrotizing Infundibular Crystalline Folliculitis (NICF), a rare cutaneous disorder with multiple waxy folliculocentric papules. Similar crystal accumulation may be seen within follicular infundibulae as an incidental finding. We describe a case showing identical crystals occurring within the horn-like crusts of a patient with erosive pustular dermatosis of the scalp (EPDS), a condition which due to its presentation can often be mistaken for nonmelanoma skin cancer...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29118366/bot-4-one-attenuates-nlrp3-inflammasome-activation-nlrp3-alkylation-leading-to-the-regulation-of-its-atpase-activity-and-ubiquitination
#13
Do-Wan Shim, Woo-Young Shin, Sang-Hyeun Yu, Byung-Hak Kim, Sang-Kyu Ye, Sushruta Koppula, Hyung-Sik Won, Tae-Bong Kang, Kwang-Ho Lee
The ATPase activity of NLRP3 has pivotal role in inflammasome activation and is recognized as a good target for the development of the NLRP3 inflammasome-specific inhibitor. However, signals in the vicinity of the ATPase activity of NLRP3 have not been fully elucidated. Here, we demonstrate NLRP3 inflammasome-specific action of a benzoxathiole derivative, BOT-4-one. BOT-4-one exhibited an inhibition of NLRP3 inflammasome activation, which was attributable to its alkylating capability to NLRP3. In particular, the NLRP3 alkylation by BOT-4-one led to an impaired ATPase activity of NLRP3, thereby obstructing the assembly of the NLRP3 inflammasome...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115436/sirt5-promotes-cell-proliferation-and-invasion-in-hepatocellular-carcinoma-by-targeting-e2f1
#14
Liang Chang, Liang Xi, Yubin Liu, Rui Liu, Zhongshi Wu, Zhixiang Jian
Sirtuin 5 (SIRT5) is a member of the NAD+‑dependent class III protein deacetylases. Although it is known that SIRT5 deacetylates and activates urate oxidase in the liver mitochondria of mice, the mechanism of SIRT5 in the proliferation of hepatocellular carcinoma (HCC) remains to be fully elucidated. The present study investigated the expression and functional significance of SIRT5 in HCC, and examined the relevant mechanism. SIRT5 was found to be upregulated in HCC tissues and cell lines, and the higher expression of SIRT5 indicated poorer overall survival...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115078/elderly-patients-exhibit-stronger-inflammatory-responses-during-gout-attacks
#15
Jae Hyun Lee, Ji Ae Yang, Kichul Shin, Ga Hye Lee, Won Woo Lee, Eun Young Lee, Yeong Wook Song, Eun Bong Lee, Jin Kyun Park
Gout attacks are often accompanied by systemic inflammatory response. The aim of the retrospective study was to compare gout patients in different age groups in terms of their clinical features at gout attacks. Patients, who were treated for gout attack in two tertiary medical centers between January 2000 and April 2014, were divided into young (≤ 50 years), middle-aged, and elderly (> 65 years) groups. Patients in three age groups were compared in terms of presence of fever (> 37.8°C), C-reactive protein (CRP) levels, and erythrocyte sedimentation ratio (ESR) at the gout attacks...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29104632/fucoidan-elevates-surface-organic-cation-transporter-2-expression-via-upregulation-of-protein-kinase-a-in-uric-acid-nephropathy
#16
Xinlin Wu, Miansheng Yan, Taoli Liu, Jiantang Liao, Jianqing Zhang, Shuqing Chen, Wei Deng, Shijun Zhang, Baoguo Sun, Houming Zhou, Bin Ke
Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis, renal diseases and cardiovascular diseases. The present study aimed to evaluate the protective effect of fucoidan, a sulfated polysaccharide component of brown algae, on UAN and to elucidate the underlying molecular mechanism. A rat model of UAN was induced by adenine treatment, and rats were then randomly assigned to control, model or fucoidan treatment groups. Hematoxylin and eosin staining of the kidney tissues of rats with UAN was subjected to conventional morphological evaluation...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103339/lesinurad-for-the-treatment-of-hyperuricaemia-in-people-with-gout
#17
Philip C Robinson, Nicola Dalbeth
Gout is a common form of inflammatory arthritis caused by deposition of monosodium urate crystals. The central strategy for effective long-term management of gout is serum urate lowering. Current urate-lowering drugs include both xanthine oxidase inhibitors and uricosuric agents. Lesinurad is a URAT1 inhibitor that selectively inhibits urate rebsorption at the proximal renal tubule. Lesinurad 200mg daily in combination with a xanthine oxidase is approved for urate-lowering therapy in patients with gout. Areas covered: The published literature was searched using Pubmed and additional information was obtained from publically available regulatory documents...
November 6, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29103248/total-anuria-in-an-infant-with-rotavirus-gastroenteritis-differential-diagnosis-between-bilaterally-obstructing-ammonium-acid-urate-aau-stones-and-bilateral-papillary-necrosis
#18
Amos Neheman, Ze'ev Korzets, Rodica Stackievicz, Tomer Itzhaki, Giulia Pula, Galit Pomeranz, Meidad Greenberg, Dganit Adam, Avishalom Pomeranz
No abstract text is available yet for this article.
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29102957/stepwise-dose-increase-of-febuxostat-is-comparable-with-colchicine-prophylaxis-for-the-prevention-of-gout-flares-during-the-initial-phase-of-urate-lowering-therapy-results-from-fortune-1-a-prospective-multicentre-randomised-study
#19
Hisashi Yamanaka, Shigenori Tamaki, Yumiko Ide, Hyeteko Kim, Kouichi Inoue, Masayuki Sugimoto, Yuji Hidaka, Atsuo Taniguchi, Shin Fujimori, Tetsuya Yamamoto
OBJECTIVES: To determine whether febuxostat with stepwise dose increase is as useful as colchicine prophylaxis in reducing gout flares during the initial introduction of urate-lowering therapy in patients with gout in comparison with febuxostat with no dose titration. METHODS: In this prospective, multicentre, randomised open-label comparative study, patients were randomised to group A (stepwise dose increase of febuxostat from 10 to 40 mg/day), group B (fixed-dose febuxostat 40 mg/day plus colchicine 0...
November 4, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29101428/composition-of-urinary-calculi-in-infants-a-report-from-an-endemic-country
#20
Mirza Naqi Zafar, Salma Ayub, Hafsa Tanwri, Syed Ali Anwar Naqvi, Syed Adibul Hasan Rizvi
Pediatric urolithiasis remains endemic in low-resource countries where infants constitute 17-40% of all children with urolithiasis. This study reports socio-economic factors, medical history and chemical composition of urinary stones in 976 infants of up to 2 years of age. Between 1992 and 2016, 976 infants presented to our institute with 1038 stones. Chemical composition of stones was analyzed by Fourier transformation infrared spectroscopy (FTIR). The mean age of infants was 19.5 ± 5.74 months with a M:F ratio of 5...
November 3, 2017: Urolithiasis
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