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https://www.readbyqxmd.com/read/28816767/allopurinol-medication-adherence-as-a-mediator-of-optimal-outcomes-in-gout-management
#1
Brian W Coburn, Kayli A Bendlin, Harlan Sayles, Jane Meza, Cynthia L Russell, Ted R Mikuls
BACKGROUND: Patient and provider factors, including allopurinol medication adherence, affect gout treatment outcomes. OBJECTIVES: The aim of this study was to examine associations of patient and provider factors with optimal gout management. METHODS: Linking longitudinal health and pharmacy dispensing records to questionnaire data, we assessed patient and provider factors among 612 patients with gout receiving allopurinol during a recent 1-year period...
August 14, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28812408/calcium-pyrophosphate-deposition-disease-a-frequent-finding-in-patients-with-long-standing-erosive-gout
#2
B Ankli, D Kyburz, A Hirschmann, T Hügle, T Manigold, C T Berger, T Daikeler
OBJECTIVE: To characterize patients with both monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals in their synovial fluid (SF). METHOD: Forty-nine gout patients with acute arthritis were included. Those patients with MSU crystals only in their SF were compared to those patients with both MSU and CPP crystals in their SF. RESULTS: A total of 36 out of 49 patients (73.5%) had only MSU crystals, whereas 13 out of 49 (26.5%) had both MSU and CPP crystals in their SF...
August 16, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28808241/specific-calpain-inhibition-protects-kidney-against-inflammaging
#3
Guillaume Hanouna, Laurent Mesnard, Sophie Vandermeersch, Joëlle Perez, Sandrine Placier, Jean-Philippe Haymann, Fabien Campagne, Julien Moroch, Aurélien Bataille, Laurent Baud, Emmanuel Letavernier
Calpains are ubiquitous pro-inflammatory proteases, whose activity is controlled by calpastatin, their specific inhibitor. Transgenic mice over-expressing rabbit calpastatin (CalpTG) are protected against vascular remodelling and angiotensin II-dependent inflammation. We hypothesized that specific calpain inhibition would protect against aging-related lesions in arteries and kidneys. We analysed tissues from 2-months and 2-years-old CalpTG and wild-type mice and performed high throughput RNA-Sequencing of kidney tissue in aged mice...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28803339/dual-energy-computed-tomography-has-limited-diagnostic-sensitivity-for-short-term-gout
#4
Ertao Jia, Junqing Zhu, Wenhui Huang, Xiaoguang Chen, Juan Li
The aim of this study was to discuss the diagnostic value of dual-energy computed tomography (DECT) in patients with gout during different disease phases. Two hundred twenty-one patients (136 with gout and 85 with other arthritic diseases) were recruited to the study. Arthrosis pain was evaluated in all patients by DECT scans. We calculated the sensitivity and specificity of DECT for the diagnosis of gout, including the first onset period, less than 24 months period, and more than 24 months period. We then investigated the related risk factors of urate crystals volume in the foot...
August 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28801728/arctium-minus-crude-extract-presents-antinociceptive-effect-in-a-mice-acute-gout-attack-model
#5
Susana Paula Moreira Fischer, Indiara Brusco, Camila Camponogara, Mariana Piana, Henrique Faccin, Luciana Assis Gobo, Leandro Machado de Carvalho, Sara Marchesan Oliveira
Gout is a disorder that triggers a severe inflammatory reaction which generates episodes of intense pain and discomfort to the patient. Arctium minus (Hill) Bernh. (Asteraceae) is known as "burdock" and displays anti-inflammatory, antinociceptive, against rheumatic pain and radical-scavenging activities. Species of the genus Arctium have been used in assistant therapy of gout and other inflammatory processes. We investigated the antinociceptive and anti-edematogenic effects of the crude extract of A. minus seeds in an acute gout attack model induced by intra-articular injection of monosodium urate (MSU) crystals in adult male Swiss mice (25-30 g)...
August 11, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28797406/ct-detected-growth-of-coronary-artery%C3%A2-calcification-in-asymptomatic-middle-aged-subjects-and-association-with-15-biomarkers
#6
Søren Zöga Diederichsen, Mette Hjortdal Grønhøj, Hans Mickley, Oke Gerke, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Lars Melholt Rasmussen, Michael Hecht Olsen, Axel Diederichsen
OBJECTIVES: This study sought to determine the incidence and progression of coronary artery calcification (CAC) in asymptomatic middle-aged subjects and to evaluate the value of a broad panel of biomarkers in the prediction of CAC growth. BACKGROUND: CAC continues to be a major risk factor, but the value of biochemical markers in predicting CAC incidence and progression remains unresolved. METHODS: At baseline, 1,227 men and women underwent traditional risk assessment and a computed tomography (CT) scan to determine the CAC score...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28797095/single-nucleotide-polymorphisms-associated-with-p2x7r-function-regulate-the-onset-of-gouty-arthritis
#7
Jin-Hui Tao, Miao Cheng, Jiang-Ping Tang, Xiao-Juan Dai, Yong Zhang, Xiang-Pei Li, Qin Liu, Ya-Ling Wang
BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals. However, some hyperuricemia patients, even gouty patients with tophi in the joints, never experience gout attack, which indicates that pathogenic pathways other than MSU participate in the secretion of IL-1β in the pathogenesis of acute gouty arthritis. The ATP-P2X7R-IL-1β axis may be one of these pathways. OBJECTIVE: This study examines the role of Adenosine triphosphate (ATP) in the pathogenesis of gout and the association of ATP receptor (P2X7R) function with single nucleotide polymorphisms and gout arthritis...
2017: PloS One
https://www.readbyqxmd.com/read/28794514/discordant-american-college-of-physicians-and-international-rheumatology-guidelines-for-gout-management-consensus-statement-of-the-gout-hyperuricemia-and-crystal-associated-disease-network-g-can
#8
REVIEW
Nicola Dalbeth, Thomas Bardin, Michael Doherty, Frédéric Lioté, Pascal Richette, Kenneth G Saag, Alexander K So, Lisa K Stamp, Hyon K Choi, Robert Terkeltaub
In November 2016, the American College of Physicians (ACP) published a clinical practice guideline on the management of acute and recurrent gout. This guideline differs substantially from the latest guidelines generated by the American College of Rheumatology (ACR), European League Against Rheumatism (EULAR) and 3e (Evidence, Expertise, Exchange) Initiative, despite reviewing largely the same body of evidence. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) convened an expert panel to review the methodology and conclusions of these four sets of guidelines and examine possible reasons for discordance between them...
August 10, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28793914/performance-of-gout-definitions-for-genetic-epidemiological-studies-analysis-of-uk-biobank
#9
Murray Cadzow, Tony R Merriman, Nicola Dalbeth
BACKGROUND: Many different combinations of available data have been used to identify gout cases in large genetic studies. The aim of this study was to determine the performance of case definitions of gout using the limited items available in multipurpose cohorts for population-based genetic studies. METHODS: This research was conducted using the UK Biobank Resource. Data, including genome-wide genotypes, were available for 105,421 European participants aged 40-69 years without kidney disease...
August 9, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28789618/genome-wide-copy-number-variation-analysis-identified-deletions-in-sfmbt1-associated-with-fasting-plasma-glucose-in-a-han-chinese-population
#10
Ren-Hua Chung, Yen-Feng Chiu, Yi-Jen Hung, Wen-Jane Lee, Kwan-Dun Wu, Hui-Ling Chen, Ming-Wei Lin, Yii-Der I Chen, Thomas Quertermous, Chao A Hsiung
BACKGROUND: Fasting glucose and fasting insulin are glycemic traits closely related to diabetes, and understanding the role of genetic factors in these traits can help reveal the etiology of type 2 diabetes. Although single nucleotide polymorphisms (SNPs) in several candidate genes have been found to be associated with fasting glucose and fasting insulin, copy number variations (CNVs), which have been reported to be associated with several complex traits, have not been reported for association with these two traits...
August 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28774457/conventional-radiology-in-crystal-arthritis-gout-calcium-pyrophosphate-deposition-and-basic-calcium-phosphate-crystals
#11
REVIEW
Thibaut Jacques, Paul Michelin, Sammy Badr, Michelangelo Nasuto, Guillaume Lefebvre, Neal Larkman, Anne Cotten
This article reviews the main radiographic features of crystal deposition diseases. Gout is linked to monosodium urate crystals. Classic radiographic features include subcutaneous tophi, large and well-circumscribed paraarticular bone erosions, and exuberant bone hyperostosis. Calcium pyrophosphate deposition (CPPD) can involve numerous structures, such as hyaline cartilages, fibrocartilages, or tendons. CPPD arthropathy involves joints usually spared by osteoarthritis. Basic calcium phosphate deposits are periarticular or intraarticular...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28774446/computed-tomography-and-mr-imaging-in-crystalline-induced-arthropathies
#12
REVIEW
Constantinus Franciscus Buckens, Maaike P Terra, Mario Maas
Crystalline-induced arthropathies impose substantial morbidity but can be challenging to diagnose, especially in early phases. The most common crystalline arthropathies are gout (monosodium urate deposition), calcium pyrophosphate dihydrate deposition, and hydroxyapatite deposition disease. Computed tomography (CT) and MR imaging provide 3-dimensional information on osseous structures, periarticular soft tissue, and tophi with superior spatial resolution. Dual-source CT (dual-energy CT [DECT]) offers the further advantage of selectively identifying crystalline deposits...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28768207/bm-muted-orthologous-to-mouse-muted-and-encoding-a-subunit-of-the-bloc-1-complex-is-responsible-for-the-otm-translucent-mutation-of-the-silkworm-bombyx-mori
#13
Haokun Zhang, Takashi Kiuchi, Lingyan Wang, Munetaka Kawamoto, Yutaka Suzuki, Sumio Sugano, Yutaka Banno, Susumu Katsuma, Toru Shimada
"Tanaka's mottled translucent" (otm) is a mutation of the silkworm Bombyx mori that exhibits translucent skin during larval stages. We performed positional cloning of the gene responsible for otm and mapped it to a 364-kb region on chromosome 5 that contains 22 hypothetical protein-coding genes. We performed RNA-seq analysis of the epidermis and fat body of otm larvae and determined that the gene BGIBMGA002619 may be responsible for the otm mutation. BGIBMGA002619 encodes the biosynthesis of lysosome-related organelles complex 1 (BLOC-1) subunit 5, whose ortholog is responsible for the Muted mutant in mouse...
July 30, 2017: Gene
https://www.readbyqxmd.com/read/28765252/management-of-gout-in-a-hospital-setting-a-lost-opportunity
#14
Sarah Wright, Peter T Chapman, Christopher Frampton, John L O'Donnell, Rafi Raja, Lisa Stamp
OBJECTIVE: Management of gout is frequently suboptimal. The aim of this study was to determine the proportion of patients presenting to Christchurch Hospital for a gout flare and to determine whether management for both acute flares and urate lowering was in accordance with international recommendations. METHODS: A retrospective audit was undertaken of all admissions to Christchurch Hospital from June 1, 2013, to May 31, 2014, in which gout was coded as a primary or secondary discharge diagnosis...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28765249/ultrasound-characteristics-of-the-achilles-tendon-in-tophaceous-gout-a-comparison-with-age-and-sex-matched-controls
#15
Matthew Carroll, Nicola Dalbeth, Bruce Allen, Sarah Stewart, Tony House, Mark Boocock, Christopher Frampton, Keith Rome
OBJECTIVE: To investigate the frequency and distribution of characteristics of the Achilles tendon (AT) in people with tophaceous gout using musculoskeletal ultrasound (US). METHODS: Twenty-four participants with tophaceous gout and 24 age- and sex-matched controls without gout or other arthritis were recruited. All participants underwent a greyscale and power Doppler US examination. The AT was divided into 3 anatomical zones (insertion, pre-insertional, and proximal to the mid-section)...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28758502/unexpected-effect-of-urate-on-hydrogen-peroxide-induced-oxidative-damage-in-embryonic-chicken-cardiac-cells
#16
Xiaolong Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin
Uric acid (UA) is a potent scavenger of oxidants in most mammalian and avian species. The aim of this study was to obtain more comprehensive information regarding the relationship between different concentrations of UA and oxidative balance in chicken cardiac cells. First, oxidative damage parameters were measured in chicken cardiac cells treated with different concentrations of UA. UA concentrations within the normal physiological range had no effect, while treatment with a high level of UA, i.e. 1200 μM, increased the malondialdehyde (MDA) and protein carbonyl contents, decreased the superoxide dismutase (SOD) and catalase (CAT) activities, and had no effect on glutathione (GSH) in cardiac muscle cells...
July 31, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28758372/metabolomic-profiling-of-long-term-weight-change-role-of-oxidative-stress-and-urate-levels-in-weight-gain
#17
Cristina Menni, Marie Migaud, Gabi Kastenmüller, Tess Pallister, Jonas Zierer, Annette Peters, Robert P Mohney, Tim D Spector, Vincenzo Bagnardi, Christian Gieger, Steve C Moore, Ana M Valdes
OBJECTIVE: To investigate the association between long-term weight change and blood metabolites. METHODS: Change in BMI over 8.6 ± 3.79 years was assessed in 3,176 females from the TwinsUK cohort (age range: 18.3-79.6, baseline BMI: 25.11 ± 4.35) measured for 280 metabolites at follow-up. Statistically significant metabolites (adjusting for covariates) were included in a multivariable least absolute shrinkage and selection operator (LASSO) model. Findings were replicated in the Cooperative Health Research in the Region of Augsburg (KORA) study (n = 1,760; age range: 25-70, baseline BMI: 27...
July 31, 2017: Obesity
https://www.readbyqxmd.com/read/28758362/metabolomic-determinants-of-metabolic-risk-in-mexican-adolescents
#18
Wei Perng, Emily C Hector, Peter X K Song, Martha Maria Tellez Rojo, Sasha Raskind, Maureen Kachman, Alejandra Cantoral, Charles F Burant, Karen E Peterson
OBJECTIVE: The goal of this study was to identify metabolites associated with metabolic risk, separately by sex, in Mexican adolescents. METHODS: Untargeted metabolomic profiling was carried out on fasting serum of 238 youth aged 8 to 14 years, and metabolites associated with a metabolic syndrome risk z-score (MetRisk z-score) were identified separately for boys and girls, using the simulation and extrapolation algorithm. Associations of each metabolite with MetRisk z-score were examined using linear regression models that accounted for maternal education, child's age, and pubertal status...
July 31, 2017: Obesity
https://www.readbyqxmd.com/read/28754803/uric-acid-and-incident-dementia-over-12-years-of-follow-up-a-population-based-cohort-study
#19
Augustin Latourte, Aicha Soumaré, Thomas Bardin, Fernando Perez-Ruiz, Stéphanie Debette, Pascal Richette
OBJECTIVES: In patients with gout, maintaining too low serum uric acid (SUA) level with urate-lowering therapy is a concern because uric acid is thought to be neuroprotective. However, the relation between SUA and dementia remains debated. This study aimed to investigate the impact of SUA level on the incidence of dementia. METHODS: We assessed the longitudinal association between SUA level and incident dementia (Diagnostic and Statistical Manual of Mental Disorders Version IV (DSM-IV) criteria) in a large cohort of healthy older people from the community (Three-City Dijon cohort)...
July 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28748426/quality-of-care-in-gout-a-clinical-audit-on-treating-to-the-target-with-urate-lowering-therapy-in-real-world-gout-patients
#20
Carly A Janssen, Tim L Th A Jansen, Martijn A H Oude Voshaar, Harald E Vonkeman, Mart A F J van de Laar
The current paper aimed to describe the quality of care for gout patients by showing the clinical outcomes achieved in two patient cohorts in which differing targeted urate lowering therapy (ULT) treatment approaches were employed, both aiming to reach the European League Against Rheumatism recommended serum urate (sUA) targets. A retrospective medical chart review study was conducted. Data from the medical records of gout patients from two clinical centers in The Netherlands, both applying targeted ULT treatments (albeit using different approaches), were reviewed...
July 26, 2017: Rheumatology International
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