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https://www.readbyqxmd.com/read/29458103/zinc-oxide-nanorod-clusters-deposited-seaweed-cellulose-sheet-for-antimicrobial-activity
#1
Priyank L Bhutiya, Mayur S Mahajan, M Abdul Rasheed, Manoj Pandey, S Zaheer Hasan, Nirendra Misra
Seaweed cellulose was isolated from green seaweed Ulva fasciata using a common bleaching agent. Sheet containing porous mesh was prepared from the extracted seaweed crystalline cellulose along with zinc oxide (ZnO) nanorod clusters grown over the sheet by single step hydrothermal method. Seaweed cellulose and zinc oxide nanorod clusters deposited seaweed cellulose sheet was characterized by FT-IR, XRD, TGA, and SEM-EDX. Morphology showed that the diameter of zinc oxide nanorods were around 70 nm. Zinc oxide nanorod clusters deposited on seaweed cellulose sheet gave remarkable antibacterial activity towards gram-positive (Staphylococcus aureus, Bacillus ceresus, Streptococcus thermophilis) and gram-negative (Escherichia coli, Pseudomonas aeruginous) microbes...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29457913/light-emitting-diode-irradiation-induced-shape-conversion-of-dna-capped-silver-nanoparticles-and-their-antioxidant-and-antibacterial-activities
#2
Navaporn Sritong, Siwat Chumsook, Sineenat Siri
Due to size- and shape-dependent properties, a shape-controlled synthesis of silver nanoparticles (AgNPs) is one of the research challenging topics for their production and potential applications. This work reported the simple eco-friendly syntheses of different shaped AgNPs controlled by the plasmid DNA content and light emitting diodes (LEDs) irradiation. The synthesized AgNPs appeared as yellow, orange and green colloidal AgNPs, which transmission electron microscope (TEM) images revealed their different shapes; spherical AgNPs, a mixture of spherical and hexagonal AgNPs, and a mixture of spherical, hexagonal and corner-truncated triangle AgNPs, respectively...
February 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29457249/gut-bacteria-of-cockroaches-are-a-potential-source-of-antibacterial-compound-s
#3
Noor Akbar, Ruqaiyyah Siddiqui, Mazhar Iqbal, K Sagathevan, Naveed Ahmed Khan
Here, we hypothesized that the microbial gut flora of animals/pests living in polluted environments, produce substances to thwart bacterial infections. The overall aim of this study was to source microbes inhabiting unusual environmental niches for potential antimicrobial activity. Two cockroach species, Gromphadorhina portentosa (Madagascar) and Blaptica dubia (Dubia) were selected. The gut bacteria from these species were isolated and grown in RPMI 1640 and conditioned media were prepared. Conditioned media were tested against a panel of Gram-positive (Methicillin resistant Staphylococcus aureus, Streptococcus pyogenes, Bacillus cereus) and Gram-negative (Escherichia coli K1, Salmonella enterica, Serratia marcescens, Pseudomonas aeruginosa, Klebsiella pneumoniae) bacteria, as well as the protist pathogen, Acanthamoeba castellanii...
February 19, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29456792/-n-leucinyl-benzenesulfonamides-as-structurally-simplified-leucyl-trna-synthetase-inhibitors
#4
Michael H Charlton, Rihards Aleksis, Adélaïde Saint-Leger, Arya Gupta, Einars Loza, Lluís Ribas de Pouplana, Ilze Kaula, Daina Gustina, Marina Madre, Daina Lola, Kristaps Jaudzems, Grace Edmund, Christopher P Randall, Louise Kime, Alex J O'Neill, Wil Goessens, Aigars Jirgensons, Paul W Finn
N -Leucinyl benzenesulfonamides have been discovered as a novel class of potent inhibitors of E. coli leucyl-tRNA synthetase. The binding of inhibitors to the enzyme was measured by using isothermal titration calorimetry. This provided information on enthalpy and entropy contributions to binding, which, together with docking studies, were used for structure-activity relationship analysis. Enzymatic assays revealed that N -leucinyl benzenesulfonamides display remarkable selectivity for E. coli leucyl-tRNA synthetase compared to S...
February 8, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29456275/antimicrobial-packaging-based-on-%C3%A9-polylysine-bioactive-film-for-the-control-of-mycotoxigenic-fungi-in-vitro-and-in-bread
#5
C Luz, J Calpe, F Saladino, Fernando B Luciano, M Fernandez-Franzón, J Mañes, G Meca
ɛ-Poly-l-lysine (ɛ-PL) is a cationic peptide with a broad-spectrum antimicrobial activity. This study investigates the use of ɛ-PL as natural antimicrobial to inhibit fungal growth and to reduce aflatoxins (AFs) production. Antifungal activity of starch biofilms with different concentrations of ɛ-Poly-l-lysine (ɛ-PL) was determined in solid medium against Aspergillus parasiticus (AFs producer) and Penicillium expansum . Then, biofilms were tested as antimicrobial devices for the preservation of bread loaf inoculated with A...
January 2018: Journal of Food Processing and Preservation
https://www.readbyqxmd.com/read/29456228/-suttonella-indologenes-peritonitis-in-a-patient-receiving-continuous-ambulatory-peritoneal-dialysis
#6
Nurhayat Ozkan Sevencan, Serkan Bakirdogen, Adem Adar, Burcak Kayhan
Suttonella indologenes is a Gram-negative, aerobic coccobacillus of Cardiobacteriaceae family and its natural habitat is the mucous membranes of the upper respiratory system. The literature includes limited number of case reports concerning fatal endocarditis due to infection in the prosthetic heart valves caused by the aforementioned microorganism. However, there is no information on extracardiac involvement due to this microorganism. Here, we present a peritonitis case caused by Suttonella indologenes in a patient receiving continuous ambulatory peritoneal dialysis...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456212/the-epidemiology-of-acute-peritonitis-in-end-stage-renal-disease-patients-on-peritoneal-dialysis-in-qatar-an-8-year-follow-up-study
#7
Abdullah Hamad, Hany Ismail, Mohamed Elsayed, Ahmad Kaddourah, Hanaa Ahmed, Rania Ibrahim, Ahlam Ali, Fadwa Alali
Acute peritonitis (AP) is a common and devastating complication in end-stage renal disease patients on peritoneal dialysis (PD). We are reporting an epidemiologic study of AP in Qatar over 8-year follow-up. We retrospectively reviewed medical records of all PD patients in Qatar from 2007 to 2014. The analysis was conducted to report epidemiology, outcome, and associated risk factors of AP. We had 318 AP episodes in 180 patients between 2007 and 2014. Six (3.3%) patients died as a result AP. Six cases of fungal peritonitis were reported...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456043/colistin-alone-versus-colistin-plus-meropenem-for-treatment-of-severe-infections-caused-by-carbapenem-resistant-gram-negative-bacteria-an-open-label-randomised-controlled-trial
#8
Mical Paul, George L Daikos, Emanuele Durante-Mangoni, Dafna Yahav, Yehuda Carmeli, Yael Dishon Benattar, Anna Skiada, Roberto Andini, Noa Eliakim-Raz, Amir Nutman, Oren Zusman, Anastasia Antoniadou, Pia Clara Pafundi, Amos Adler, Yaakov Dickstein, Ioannis Pavleas, Rosa Zampino, Vered Daitch, Roni Bitterman, Hiba Zayyad, Fidi Koppel, Inbar Levi, Tanya Babich, Lena E Friberg, Johan W Mouton, Ursula Theuretzbacher, Leonard Leibovici
BACKGROUND: Colistin-carbapenem combinations are synergistic in vitro against carbapenem-resistant Gram-negative bacteria. We aimed to test whether combination therapy improves clinical outcomes for adults with infections caused by carbapenem-resistant or carbapenemase-producing Gram-negative bacteria. METHODS: A randomised controlled superiority trial was done in six hospitals in Israel, Greece, and Italy. We included adults with bacteraemia, ventilator-associated pneumonia, hospital-acquired pneumonia, or urosepsis caused by carbapenem-non-susceptible Gram-negative bacteria...
February 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29456042/evidence-to-improve-the-treatment-of-infections-caused-by-carbapenem-resistant-gram-negative-bacteria
#9
Federico Perez, Robert A Bonomo
No abstract text is available yet for this article.
February 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29456028/polyphasic-characterization-of-a-novel-species-in-the-lactobacillus-casei-group-from-cow-manure-of-taiwan-description-of-l-chiayiensis-sp-nov
#10
Chien-Hsun Huang, Jong-Shian Liou, Ai-Yun Lee, Min Tseng, Mika Miyashita, Lina Huang, Koichi Watanabe
Two Gram-stain-positive, rod-shaped, non-motile, catalase-negative and facultative anaerobic strains, NCYUAST and BCRC 18859 (=NRIC 1947), were isolated from cow manure of Taiwan and coconut juice of Philippines, respectively. Comparative sequence analysis of 16S rRNA gene revealed that the novel strains were members of the genus Lactobacillus. These two strains had 100% of 16S rRNA gene sequence similarity and 98.6% of average nucleotide identity (ANI) value based on whole genome sequences. On the basis of 16S rRNA gene sequence similarity, the type strains of Lactobacillus casei (99...
February 7, 2018: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29455989/biocompatible-nanocomposite-of-carboxymethyl-cellulose-and-functionalized-carbon-norfloxacin-intercalated-layered-double-hydroxides
#11
N'guadi Blaise Allou, Archana Yadav, Mintu Pal, Rajib Lochan Goswamee
In recent years, the development of systems with progressive drug release properties, which is an effective technique for the use of drugs, has aroused great interest in the field of controlled release formulations. In this work, hybrid materials containing citric acid cross-linked carboxymethyl cellulose (CMC) and norfloxacin (NOR) intercalated layered double hydroxide (LDH) deposited over the surface of functionalized carbon (AC) were prepared. The synthesized CMC@AC-LDHNOR nanohybrids were characterized using different techniques and in vitro NOR release behaviors were investigated in phosphate buffer saline, pH 7...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455988/fabrication-of-novel-nanohybrids-by-impregnation-of-cuo-nanoparticles-into-bacterial-cellulose-and-chitosan-nanofibers-characterization-antimicrobial-and-release-properties
#12
Hadi Almasi, Paria Jafarzadeh, Laleh Mehryar
The efficiency of bacterial cellulose nanofibers (BCNF) and chitosan nanofibers (CHNF) were compared, aiming at fabricating novel organic-inorganic nanohybrids containing copper oxide (CuO) nanoparticles (NPs). FT-IR spectra confirmed the formation of real nanohybrids through occurring new interactions between CuO NPs and nanofibers. XRD results indicated that both the crystallite size and the crystallinity index of nanofibers decreased after nanohybrid formation. Noticeably, these morphological changes for CHNF were more than those for BCNF...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455272/the-outcome-and-timing-of-death-of-17-767-nosocomial-bloodstream-infections-in-acute-care-hospitals-in-finland-during-1999-2014
#13
Keiju S K Kontula, Kirsi Skogberg, Jukka Ollgren, Asko Järvinen, Outi Lyytikäinen
Few studies covering all patient groups and specialties are available regarding the outcome of nosocomial bloodstream infections (BSI). We analyzed the role of patient characteristics and causative pathogens of nosocomial BSIs reported by the hospitals participating in national surveillance in Finland during 1999-2014, in terms of outcome, with particular interest in those leading to death within 2 days (i.e. early death). National nosocomial BSI surveillance was laboratory-based and hospital-wide. Data on nosocomial BSIs was collected by infection control nurses, and dates of death were obtained from the national population registry with linkage to national identity codes...
February 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29455109/dysregulation-of-jak-stat-genes-by-vasoactive-intestinal-peptide-vip-in-salmonella-infected-monocytes-may-inhibit-its-therapeutic-potential-in-human-sepsis
#14
Hiba Ibrahim, Basim Askar, Paul Barrow, Neil Foster
Murine/LPS models of Gram negative sepsis indicate that vasoactive intestinal peptide (VIP) has therapeutic potential. We investigated the unknown effect of VIP on JAK/STAT proteins and genes in human monocytes infected with Salmonella Typhimurium 14028. S. Typhimurium 14028 increased expression of both IL-6 receptor (IL-6R) and interferon gamma receptor 1 (IFNγR1) on monocytes but co-culture of infected monocytes with VIP (10-7 M) only decreased expression of IFNγR1 (P < 0.05). In contrast, S. Typhimurium 14028 infection or co-culture with VIP had no effect on IL-10 receptor expression on the monocyte surface...
February 15, 2018: Cytokine
https://www.readbyqxmd.com/read/29454921/sequential-pretreatment-for-cell-disintegration-of-municipal-sludge-in-a-neutral-bio-electro-fenton-system
#15
Qilin Yu, Xiaochen Jin, Yaobin Zhang
Sludge cell disruption was generally considered as the rate-limiting step for the anaerobic digestion of waste activated sludge (WAS). Advanced oxidation processes and bio-electro-chemical systems were recently reported to enhance the hydrolysis of WAS and sludge cell disruption, while the cell-breaking processes of these systems remain unclear yet. In this study, an innovative Bio-electro-Fenton system was developed to pretreat the WAS sequentially with cathode Fenton process and anode anaerobic digestion...
February 9, 2018: Water Research
https://www.readbyqxmd.com/read/29454906/risk-factors-for-pseudomonas-aeruginosa-infections-consequences-of-inappropriate-initial-antimicrobial-therapy-a-systematic-literature-review-meta-analysis
#16
REVIEW
Sanjay Merchant, Emma M Proudfoot, Hafsa N Quadri, Heather J McElroy, William R Wright, Ankur Gupta, Eric M Sarpong
Treating infections of Gram-negative pathogens, in particular Pseudomonas aeruginosa, is a challenge for clinicians in the Asia-Pacific region due to inherent and acquired resistance to antimicrobials. This systematic review and meta-analysis provides updated information of the risk factors for P. aeruginosa infections in Asia-Pacific, and consequences (e.g., mortality, costs) of initial inappropriate antimicrobial therapy (IIAT). EMBASE and MEDLINE databases were searched for Asia-Pacific studies reporting the consequences of IIAT versus initial appropriate antimicrobial therapy (IAAT) in Gram-negative infections, and risk factors for serious P...
February 15, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29454879/application-of-genetically-encoded-redox-biosensors-to-measure-dynamic-changes-in-the-glutathione-bacillithiol-and-mycothiol-redox-potentials-in-pathogenic-bacteria
#17
REVIEW
Quach Ngoc Tung, Nico Linzner, Vu Van Loi, Haike Antelmann
Gram-negative bacteria utilize glutathione (GSH) as their major LMW thiol. However, most Gram-positive bacteria do not encode enzymes for GSH biosynthesis and produce instead alternative LMW thiols, such as bacillithiol (BSH) and mycothiol (MSH). BSH is utilized by Firmicutes and MSH is the major LMW thiol of Actinomycetes. LMW thiols are required to maintain the reduced state of the cytoplasm, but are also involved in virulence mechanisms in human pathogens, such as Staphylococcus aureus, Mycobacterium tuberculosis, Streptococcus pneumoniae, Salmonella enterica subsp...
February 15, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29454808/a-new-multifunctionalized-material-against-multi-drug-resistant-bacteria-and-abnormal-osteoclast-activity
#18
Elisa Boanini, Paola Torricelli, Francesca Bonvicini, Maria Cristina Cassani, Milena Fini, Giovanna Angela Gentilomi, Adriana Bigi
The development of new biomaterials able to favor bone formation and to inhibit bone abnormal resorption is mandatory to face the increasing number of age-related musculo-skeletal disorders. Moreover, the increasing antibiotic resistance of clinically important bacteria, which is among the main causes of implant failure, requires new antimicrobial systems. In this study, we prepared multifunctional materials consisting of hydroxyapatite-zoledronate composite crystals decorated with Ag Nanoparticles (AgNPs)...
February 15, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29454787/trans-envelope-multidrug-efflux-pumps-of-gram-negative-bacteria-and-their-synergism-with-the-outer-membrane-barrier
#19
Helen I Zgurskaya, Valentin V Rybenkov, Ganesh Krishnamoorthy, Inga V Leus
Antibiotic resistance is a serious threat to public health. Significant efforts are currently directed toward containment of the spread of resistance, finding new therapeutic options concerning resistant human and animal pathogens, and addressing the gaps in the fundamental understanding of mechanisms of resistance. Experimental data and kinetic modeling revealed a major factor in resistance, the synergy between active efflux and the low permeability barrier of the outer membrane, which dramatically reduces the intracellular accumulation of many antibiotics...
February 15, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29454770/molecular-imaging-of-apoptosis-in-ischemia-reperfusion-injury-with-radiolabeled-duramycin-targeting-phosphatidylethanolamine-effective-target-uptake-and-reduced-nontarget-organ-radiation-burden
#20
Hideki Kawai, Farhan Chaudhry, Aditya Shekhar, Artiom Petrov, Takehiro Nakahara, Takashi Tanimoto, Dongbin Kim, Jiqiu Chen, Djamel Lebeche, Francis G Blankenberg, Koon Y Pak, Frank D Kolodgie, Renu Virmani, Partho Sengupta, Navneet Narula, Roger J Hajjar, Harry W Strauss, Jagat Narula
OBJECTIVES: The purpose of this study was to evaluate the feasibility of imaging apoptosis in experimental ischemia-reperfusion model by technetium-99m (99m Tc)-labeled Duramycin, and compare it to an established tracer,99m Tc-labeled Annexin-V, which has a relative disadvantage of high radiation burden to nontarget organs. BACKGROUND: During apoptosis, the cell membrane phospholipids-phosphatidylserine (PS) and phosphatidylethanolamine (PE) are exposed and can be targeted by Annexin-V and Duramycin, respectively, for in vivo imaging...
February 9, 2018: JACC. Cardiovascular Imaging
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