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https://www.readbyqxmd.com/read/29677694/3s-systematic-systemic-and-systems-biology-and-toxicology
#1
Lena Smirnova, Nicole Kleinstreuer, Raffaella Corvi, Andre Levchenko, Suzanne C Fitzpatrick, Thomas Hartung
A biological system is more than the sum of its parts - it accomplishes many functions via synergy. Deconstructing the system down to the molecular mechanism level necessitates the complement of reconstructing functions on all levels, i.e., in our conceptualization of biology and its perturbations, our experimental models and computer modelling. Toxicology contains the somewhat arbitrary subclass "systemic toxicities"; however, there is no relevant toxic insult or general disease that is not systemic...
2018: ALTEX
https://www.readbyqxmd.com/read/29677654/diagnosis-of-lumbar-spinal-fractures-in-emergency-department-low-dose-versus-standard-dose-ct-using-model-based-iterative-reconstruction
#2
Sun Hwa Lee, Seong Jong Yun, Hyeon Hwan Jo, Jae Gwang Song
PURPOSE: To compared the diagnostic performance of low-dose (LD) lumbar-spine (L-spine) CT with that of standard-dose (SD) L-spine CT. METHODS: Patients who underwent SD (n = 76) or LD (n = 68) L-spine CT using model-based iterative reconstruction were included. Two reviewers independently analyzed 10 anatomical regions on both CT scans. Also, suggested treatment decision between both CT scans was compared. RESULTS: LD L-spine CT showed an excellent diagnostic accuracy (98...
April 14, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29677404/hybrid-scaffolds-of-mg-alloy-mesh-reinforced-polymer-extracellular-matrix-composite-for-critical-sized-calvarial-defect-reconstruction
#3
Yingqi Chen, Sang-Ho Ye, Hideyoshi Sato, Yang Zhu, Vesselin Shanov, Tarannum Tiasha, Antonio D'Amore, Samuel Luketich, Guojiang Wan, William R Wagner
The challenge of developing scaffolds to reconstruct critical-sized calvarial defects without the addition of high levels of exogenous growth factor remains relevant. Both osteogenic regenerative efficacy as well as suitable mechanical properties for the temporary scaffold system are of importance. In this study, a Mg alloy mesh reinforced polymer/demineralized bone matrix (DBM) hybrid scaffold was designed where the hybrid scaffold was fabricated by a concurrent electrospinning/electrospraying of poly(lactic-co-glycolic) (PLGA) polymer and DBM suspended in hyaluronic acid (HA)...
April 20, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29677225/occlusive-titanium-barrier-for-immediate-bone-augmentation-of-severely-resorbed-alveolar-sockets-with-secondary-soft-tissue-healing-a-2-year-case-series
#4
Fabio Perret, Federica Romano, Francesco Ferrarotti, Mario Aimetti
This case series evaluated bone dimensional changes following the application of an occlusive titanium barrier on severely resorbed fresh extraction sockets to achieve bone regeneration. Six extraction sites with buccal bone loss were filled with a xenograft and covered with a titanium plate fixed by two miniscrews and left intentionally exposed. No infection occurred. After 4 months of healing, sufficient hard tissue had formed to allow implant insertion. Mean vertical bone gain was 7.3 ± 2.2 mm at the buccal side and 4...
April 20, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29677163/microstructure-images-restoration-of-metallic-materials-based-upon-ksvd-and-smoothing-penalty-sparse-representation-approach
#5
Qing Li, Steven Y Liang
Microstructure images of metallic materials play a significant role in industrial applications. To address image degradation problem of metallic materials, a novel image restoration technique based on K-means singular value decomposition (KSVD) and smoothing penalty sparse representation (SPSR) algorithm is proposed in this work, the microstructure images of aluminum alloy 7075 (AA7075) material are used as examples. To begin with, to reflect the detail structure characteristics of the damaged image, the KSVD dictionary is introduced to substitute the traditional sparse transform basis (TSTB) for sparse representation...
April 20, 2018: Materials
https://www.readbyqxmd.com/read/29677135/molecular-evolution-and-expression-divergence-of-hmt-gene-family-in-plants
#6
Man Zhao, Peng Chen, Wenyi Wang, Fengjie Yuan, Danhua Zhu, Zhao Wang, Xiangxian Ying
Homocysteine methyltransferase (HMT) converts homocysteine to methionine using S -methylmethionine (SMM) or S -adenosylmethionine (SAM) as methyl donors in organisms, playing an important role in supplying methionine for the growth and the development of plants. To better understand the functions of the HMT genes in plants, we conducted a wide evolution and expression analysis of these genes. Reconstruction of the phylogenetic relationship showed that the HMT gene family was divided into Class 1 and Class 2...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29677124/estimation-of-longitudinal-force-and-sideslip-angle-for-intelligent-four-wheel-independent-drive-electric-vehicles-by-observer-iteration-and-information-fusion
#7
Te Chen, Long Chen, Xing Xu, Yingfeng Cai, Haobin Jiang, Xiaoqiang Sun
Exact estimation of longitudinal force and sideslip angle is important for lateral stability and path-following control of four-wheel independent driven electric vehicle. This paper presents an effective method for longitudinal force and sideslip angle estimation by observer iteration and information fusion for four-wheel independent drive electric vehicles. The electric driving wheel model is introduced into the vehicle modeling process and used for longitudinal force estimation, the longitudinal force reconstruction equation is obtained via model decoupling, the a Luenberger observer and high-order sliding mode observer are united for longitudinal force observer design, and the Kalman filter is applied to restrain the influence of noise...
April 20, 2018: Sensors
https://www.readbyqxmd.com/read/29676618/cancer-risk-from-paediatric-computed-tomography-scanning-implications-for-radiation-protection-in-medicine
#8
A Kesminiene, E Cardis
The use of computed tomography (CT) imaging is clearly beneficial for millions of patients. However, the potential adverse health effects, particularly cancer, of ionising radiation exposure from CT early in life are an issue of growing concern in the radiological protection, medical, and public health communities. Although efforts to quantify these effects have been conducted, the precision and accuracy of reported risks needs confirmation. EPI-CT, a European collaborative epidemiological study, was set up to quantify risks from paediatric CT to optimise paediatric diagnostic protocol...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29676498/are-older-people-a-vulnerable-group-philosophical-and-bioethical-perspectives-on-ageing-and-vulnerability
#9
Claudia Bozzaro, Joachim Boldt, Mark Schweda
The elderly are often considered a vulnerable group in public and academic bioethical debates and regulations. In this paper, we examine and challenge this assumption and its ethical implications. We begin by systematically delineating the different concepts of vulnerability commonly used in bioethics, before then examining whether these concepts can be applied to old age. We argue that old age should not, in and of itself, be used as a marker of vulnerability, since ageing is a process that can develop in a variety of different ways and is not always associated with particular experiences of vulnerability...
May 2018: Bioethics
https://www.readbyqxmd.com/read/29676463/evaluation-of-machine-log-files-mc-based-treatment-planning-and-delivery-qa-as-compared-to-arccheck-qa
#10
Carl W Stanhope, Douglas G Drake, Jian Liang, Markus Alber, Matthias Söhn, Charbel Habib, Virgil Willcut, Di Yan
PURPOSE: A treatment planning/delivery QA tool using linac log files (LF) and Monte Carlo (MC) dose calculation is investigated as a standalone alternative to phantom-based patient-specific QA (ArcCHECK (AC)). METHODS: Delivering a variety of fields onto MapCHECK2 and ArcCHECK, diode sensitivity dependence on dose rate (in-field) and energy (primarily out-of-field) was quantified. AC and LF QAs were analyzed w.r.t. delivery complexity by delivering 12x12cm static fields/arcs comprised of varying numbers of abutting sub-fields onto ArcCHECK...
April 20, 2018: Medical Physics
https://www.readbyqxmd.com/read/29676403/combined-endoscopic-transorbital-and-endonasal-repair-of-high-flow-orbital-apex-middle-fossa-cerebrospinal-fluid-leak-with-a-nasoseptal-flap
#11
Brandon Lucke-Wold, Gustavo Mendez, David Cua, Paul Akins, Haley Gillham, Jeremy Ciporen
Background and importance: High flow orbital apex or middle fossa cerebrospinal fluid (CSF) leaks can be life threatening and complex to repair. These leaks associated with large dural defects are most commonly repaired with an open temporalis muscle patch or free flaps, but these flaps do not always stop the leak. Clinical Presentation: A 65-year-old patient presented two years after orbital exenteration and radiation for squamous cell carcinoma. He developed multi-organism meningitis and pneumocephalus secondary to a large high-flow orbital apex/middle fossa CSF leak...
2018: J Neuroinflamm Neurodegener Dis
https://www.readbyqxmd.com/read/29675796/construction-of-transcriptional-regulatory-network-of-alzheimer-s-disease-based-on-panda-algorithm
#12
Jieyuan Ding, Wei Kong, Xiaoyang Mou, Shuaiqun Wang
The focus of modern biomedical research concentrates on molecular level regulatory mechanisms and how the normal and abnormal phenotypes of tissue functional are affected by regulatory mechanisms. Most of the research on regulatory mechanism starts from the reconstruction of gene regulation network. At present, a large number of reconstruction methods construct the network using a single data set. These methods of inferring and predicting the relationship between the target gene and the transcription factor (TF) can be used to identify individual interactions between genes, while there is not much research on the interaction of many functional-related genes...
April 19, 2018: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29675743/single-versus-double-bundle-pcl-reconstruction-scientific-rationale-and-clinical-evidence
#13
REVIEW
Christopher J Tucker, Patrick W Joyner, Nathan K Endres
PURPOSE OF REVIEW: The goal of this paper is to review the biomechanical and clinical rationale for single-bundle versus double-bundle posterior cruciate ligament (PCL) reconstruction. The primary question is whether there has been demonstrated any clear biomechanical or clinical superiority of a double-bundle reconstruction over a single-bundle reconstruction. RECENT FINDINGS: There is some recent evidence demonstrating biomechanical superiority of double-bundle versus single-bundle reconstruction; however, this is not definitive...
April 19, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29675721/fenestration-of-the-supraclinoid-segment-of-the-ica-and-associated-aneurysms-a-case-report-with-literature-review
#14
Alessandro Sgreccia, Oguzhan Coskun, Federico Di Maria, Georges Rodesch, Arturo Consoli
The supraclinoid ICA fenestration (SIF) is considered an extremely rare congenital anomaly. However, most of the reported cases of SIF are associated with intracranial aneurysms either ruptured or unruptured. We report the case of a 55-year-old patient with a right SIF and an unruptured, large, wide-necked aneurysm located on the larger limb of the fenestration and a second small aneurysm distal to the SIF. The aneurysms were treated with a Pipeline flow-diverter stent, achieving the complete reconstruction of the anatomy of the carotid siphon...
April 20, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29675685/laplace-based-modeling-of-fiber-orientation-in-the-tongue
#15
Arnold D Gomez, Nahla Elsaid, Maureen L Stone, Jiachen Zhuo, Jerry L Prince
Mechanical modeling of tongue deformation plays a significant role in the study of breathing, swallowing, and speech production. In the absence of internal joints, fiber orientations determine the direction of sarcomeric contraction and have great influence over real and simulated tissue motion. However, subject-specific experimental observations of fiber distribution are difficult to obtain; thus, models of fiber distribution are generally used in mechanical simulations. This paper describes modeling of fiber distribution using solutions of Laplace equations and compares the effectiveness of this approach against tractography from diffusion tensor magnetic resonance imaging...
April 19, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29675503/factors-affecting-subjective-and-objective-outcomes-and-return-to-play-in-anterior-cruciate-ligament-reconstruction-a-retrospective-cohort-study
#16
Federica Rosso, Davide E Bonasia, Umberto Cottino, Simone Cambursano, Federico Dettoni, Roberto Rossi
Purpose  To analyze the prognostic factors influencing subjective and objective outcomes and return to play (RTP) after anterior cruciate ligament reconstruction (ACL-R). Methods  Primary ACL-Rs using a transtibial technique performed between 2008 and 2012 were included. Data regarding patients, surgery, sports, and rehabilitation, including an on-field rehabilitation (OFR) and duration of the rehabilitation program, were collected. The International Knee Documentation Committee (IKDC) subjective and objective evaluation forms, and the Knee Injury and Osteoarthritis Outcome Score and Lysholm questionnaires were used for the assessment of subjective and objective outcomes...
March 2018: Joints
https://www.readbyqxmd.com/read/29675501/does-donor-age-of-nonirradiated-achilles-tendon-allograft-influence-mid-term-results-of-revision-acl-reconstruction
#17
Stefano Zaffagnini, Tommaso Roberti di Sarsina, Tommaso Bonanzinga, Marco Nitri, Luca Macchiarola, Federico Stefanelli, Gianandrea Lucidi, Alberto Grassi
Purpose  The purpose of the present study was to investigate if the donor age of nonirradiated Achilles tendon allograft could influence the clinical results of revision anterior cruciate ligament (ACL) reconstruction. Methods  All patients that underwent ACL revision between 2004 and 2008 with at least 4 years of follow-up were included. For all the patients that met the inclusion criteria, the age of the graft donor was obtained from the tissue bank. Lysholm score was administered to patients that met inclusion criteria...
March 2018: Joints
https://www.readbyqxmd.com/read/29675473/comprehensive-algorithm-for-nasal-ala-reconstruction-utility-of-the-auricular-composite-graft
#18
REVIEW
Collin Chen, Ruchin Patel, John Chi
Defects of the nasal ala are challenging to reconstruct, given its complex three-dimensional structure. Successful repair of these defects needs to provide aesthetic symmetry and preserve nasal function. A wide variety of reconstructive options have been described for nasal ala defects, ranging from skin grafts to locoregional flaps, and also includes the auricular composite graft. However, there are currently no comprehensive guidelines for nasal ala repair, and the versatile role of the auricular composite graft has not been well defined...
April 2018: Surgery Journal
https://www.readbyqxmd.com/read/29675394/cryopreserved-limbal-lamellar-keratoplasty-for-peripheral-corneal-and-limbal-reconstruction
#19
Hua-Tao Xie, Jing Li, Yang Liu, Dong-Ling Jiang, Rui-Fen Shen, Ming-Chang Zhang
This study aimed to evaluate the outcomes and described the recovery process of cryopreserved limbal lamellar keratoplasty (CLLK) for peripheral corneal and limbal diseases. Thirteen eyes of 12 patients with a mean age of 41±23.9y were included. The average follow-up was 12.1±5.6mo. Stable ocular surface was achieved in all eyes at last follow-up. Epithelialization originated from both recipient and graft in 9 eyes. We conclude that CLLK compensates for the shortage of donor corneas and cryopreserved limbal grafts provide epithelialization sources in ocular surface reconstruction...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675361/a-survey-of-gpu-based-acceleration-techniques-in-mri-reconstructions
#20
REVIEW
Haifeng Wang, Hanchuan Peng, Yuchou Chang, Dong Liang
Image reconstruction in magnetic resonance imaging (MRI) clinical applications has become increasingly more complicated. However, diagnostic and treatment require very fast computational procedure. Modern competitive platforms of graphics processing unit (GPU) have been used to make high-performance parallel computations available, and attractive to common consumers for computing massively parallel reconstruction problems at commodity price. GPUs have also become more and more important for reconstruction computations, especially when deep learning starts to be applied into MRI reconstruction...
March 2018: Quantitative Imaging in Medicine and Surgery
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