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Irene Sintini, William S Burton, Paul Sade, Jason M Chavarria, Peter J Laz
Morphological variability in the shoulder influences the joint biomechanics and is an important consideration in arthroplasty and implant design. The objectives of this study were to quantify cortical and cancellous proximal humeral morphology and to assess whether shape variation was influenced by gender and ethnicity, with the overarching goal of informing implant design and treatment. A statistical shape model of the proximal humeral cortical and cancellous regions was developed for a training set of 84 subjects of both genders and different ethnicities...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Juan Sebastián Celis, Daniel Wibberg, Catalina Ramírez-Portilla, Oliver Rupp, Alexander Sczyrba, Anika Winkler, Jörn Kalinowski, Thomas Wilke
Background: Many cnidarians, including stony corals, engage in complex symbiotic associations, comprising the eukaryotic host, photosynthetic algae, and highly diverse microbial communities-together referred to as holobiont. This taxonomic complexity makes sequencing and assembling coral host genomes extremely challenging. Therefore, previous cnidarian genomic projects were based on symbiont-free tissue samples. However, this approach may not be applicable to the majority of cnidarian species for ecological reasons...
June 18, 2018: GigaScience
Loreto Castellon, Daniel Jerez, Jaime Mayorga, Alejandra Gallego, Carlos Fuenzalida, German Laissle
: Mandibular reconstruction in pediatric patients is controversial. The scant pediatric experience and the infrequent occurrence of this type of pathology in children complicate therapeutic decisions. The literature contains different treatment protocols and describes the bone graft alternatives to be used. MATERIALS AND METHOD: This is a retrospective review of patients under the age of 15 who were subjected to resection and reconstruction. RESULTS: A total of 18 patients were included in the study: 8 women and 10 men...
June 18, 2018: Journal of Craniofacial Surgery
Pedro Jorge Cavalcante Costa, Johnny Holanda de Gauw, José Zenou Costa Filho, Raphael Teixeira Moreira, Paulo Domingos Ribeiro Júnior
Treatment of orbital fractures involves restoration of lost bone anatomy and orbital volume. Among the materials used for this purpose, the titanium mesh is widely used due to its effectiveness and low complication rate related to distortion especially in non-traumatic events. This study shows an atypical and late complication involving the deformation of the titanium mesh used during reconstruction of the orbital floor in a patient with orbital zygomatic complex fracture 5 months after the procedure and without traumatic etiology...
June 18, 2018: Journal of Craniofacial Surgery
Kyoung Ho Yoon, Jung Suk Kim, Soo Yeon Park, Sang Eon Park
BACKGROUND: Bone tunnel enlargement is one of the important factors that determine whether a revision anterior cruciate ligament reconstruction (ACLR) should be performed in 1 or 2 stages. The goal of this retrospective cohort study was to compare the mid-term to long-term outcomes of 1-stage revision ACLR according to the amount of preoperative tunnel enlargement. METHODS: Between January 2002 and January 2012, 88 patients who underwent revision ACLR were enrolled...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
Lisa M Block, Caleb J Ollech, Samuel O Poore, Ahmed M Afifi
No abstract text is available yet for this article.
June 19, 2018: Annals of Plastic Surgery
Hyun Ho Han, Hyung Bae Kim, Eun Key Kim, Jin Sup Eom
BACKGROUND: Immediate single-stage direct-to-implant breast reconstruction requires caution owing to the possibility of skin necrosis and implant failure. Nevertheless, this method has been performed widely for breast reconstruction. This study aimed to analyze the safety of single-stage implant reconstruction by comparing it with 2-stage reconstruction (TSR). METHODS: Immediate single-stage reconstructions (SSRs) and TSRs with a tissue expander, performed from January 2011 to December 2016, were retrospectively reviewed...
June 19, 2018: Annals of Plastic Surgery
James J Jung, Peter Jüni, Gerald Lebovic, Teodor Grantcharov
OBJECTIVE: To characterize intraoperative errors, events, and distractions, and measure technical skills of surgeons in minimally invasive surgery practice. BACKGROUND: Adverse events in the operating room (OR) are common contributors of morbidity and mortality in surgical patients. Adverse events often occur due to deviations in performance and environmental factors. Although comprehensive intraoperative data analysis and transparent disclosure have been advocated to better understand how to improve surgical safety, they have rarely been done...
June 18, 2018: Annals of Surgery
Sungmin Kim, Sun Ouk Yi, Myungchul Oh, Bo Gyu Jang, W Nam, Yong-Chan Yoo, Minjun Lee, Hoyean Jeon, Inhae Zoh, Hanho Lee, Chao Zhang, Kee Hoon Kim, JungPil Seo, Ji Hoon Shim, Jungseok Chae, Young Kuk
Whether or not epitaxially grown superconducting films have the same bulk-like superconducting properties is an important concern. We report the structure and the electronic properties of epitaxially grown Ba(Fe1-xCox)2As2 films using scanning tunneling microscopy and scanning tunneling spectroscopy (STS). This film showed a different surface structure, (2√2×2√2)R45º reconstruction, from those of as-cleaved surfaces from bulk crystals. The electronic structure of the grown film is different from that in bulk, and it is notable that the film exhibits the same superconducting transport properties...
June 19, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Hongfu Sun, Ana C Klahr, Mahesh Kate, Laura C Gioia, Derek J Emery, Kenneth S Butcher, Alan H Wilman
Purpose To follow the evolution of intracranial hemorrhage (ICH) by using quantitative susceptibility mapping (QSM). Materials and Methods Thirty-six patients with ICH confirmed at CT were enrolled to follow ICH evolution on day 2, 7, and 30 after symptom onset between August 2013 and April 2017. QSM was reconstructed from MRI gradient-echo phase images acquired at 1.5 T or 3.0 T. ICH regions were manually drawn on two-dimensional sections of co-registered CT and MR images independently by two raters. The ICH areas and mean values were compared between CT and MRI by using Bland-Altman plots and Pearson correlation...
June 19, 2018: Radiology
Katharina Brehmer, Torkel B Brismar, Fabian Morsbach, Anders Svensson, Per Stål, Antonios Tzortzakakis, Nikolaos Voulgarakis, Michael A Fischer
Purpose To develop and evaluate a triple arterial phase CT liver protocol with a similar radiation dose to that of standard single arterial phase CT in study subjects suspected of having hepatocellular carcinoma (HCC). Materials and Methods The study consisted of a retrospective part A for protocol development (n = 15) and a prospective part B to evaluate diagnostic accuracy (n = 38). All 53 participants underwent perfusion CT with 50 mL contrast material between August 2013 and September 2014. Group B underwent an additional standard multiphasic liver CT examination with 120 mL of contrast material (range, 70-143 mL)...
June 19, 2018: Radiology
Bjoern Sommer, Stefan Rampp, Arnd Doerfler, Hermann Stefan, Hajo M Hamer, Michael Buchfelder, Karl Roessler
OBJECTIVES: One of the main obstacles of electrode implantation in epilepsy surgery is the electrode shift between implantation and the day of explantation. We evaluated this possible electrode displacement using intraoperative MRI (iopMRI) data and CT/MRI reconstruction. METHODS: Thirteen patients (nine female, four male, median age 26 ± 9.4 years) suffering from drug-resistant epilepsy were examined. After implantation, the position of subdural electrodes was evaluated by 3...
June 19, 2018: Neurological Research
Jérémie Bettoni, Gwénaël Pagé, Anne-Virginie Salsac, Jean-Marc Constans, Sylvie Testelin, Bernard Devauchelle, Olivier Balédent, Stéphanie Dakpé
Owing to the lack of databases of blood flow distributions in the external carotid branches, surgeons currently rely on per-operative imaging and on their experience to choose the recipient vessels for microsurgical facial reconstructions. But, thanks to three-dimensional phase contrast angiography (PCA) and kinematic CINE phase contrast (PC) sequences, MRI technologies have the potential to provide quantitative anatomical and hemodynamic information without injection of contrast agent. Having developed and optimized PC-MRI sequences for the small facial vessels, our objective was to investigate the haemodynamic and blood flow distribution in the external carotid branches...
June 19, 2018: Dento Maxillo Facial Radiology
Saturnino Marco Lupi, Pietro Galinetto, Matteo Cislaghi, Arianna Rodriguez Y Baena, Andrea Scribante, Ruggero Rodriguez Y Baena
OBJECTIVES: To evaluate the geometric distortion of tilting of mandibular third molars with respect to second molars on panoramic reconstruction. MATERIAL AND METHODS: Cone-beam computed tomography (CBCT) reconstructions of 160 third molars, obtained due to an indication of risk of inferior alveolar nerve damage during surgery, were used. CBCT-reconstructed panoramic images were used as bi-dimensional images, to avoid distortions other than geometric distortions...
June 19, 2018: Dento Maxillo Facial Radiology
Shuang Zhang, Chenqiong Zhao, Shi Liu, Yufeng Wang, Yuhua Zhao, Weijun Guan, Zhiqiang Zhu
Bone marrow mesenchymal stem cells (BM‑MSCs) are pluripotent stem cells that are regarded as ideal resources for the reconstruction of tissues and organs. The Tibetan mastiff is a breed of domesticated Chinese native dog that is well‑adjusted to the high‑altitude environments of Tibet. To the best of our knowledge, the biological characterization and multi‑lineage differentiation of Tibetan mastiff BM‑MSCs have not been reported previously. Therefore, the present study aimed to investigate the biological characteristics and therapeutic potential of Tibetan mastiff BM‑MSCs...
June 15, 2018: Molecular Medicine Reports
Brandon P Hedrick, Laurel Yohe, Abby Vander Linden, Liliana M Dávalos, Karen Sears, Alexa Sadier, Stephen J Rossiter, Kalina T J Davies, Elizabeth Dumont
The increased accessibility of soft-tissue data through diffusible iodine-based contrast-enhanced computed tomography (diceCT) enables comparative biologists to increase the taxonomic breadth of their studies with museum specimens. However, it is still unclear how soft-tissue measurements from preserved specimens reflect values from freshly collected specimens and whether diceCT preparation may affect these measurements. Here, we document and evaluate the accuracy of diceCT in museum specimens based on the soft-tissue reconstructions of brains and eyes of five bats...
June 19, 2018: Microscopy and Microanalysis
Fengjuan Liu, Jinji Liu, Zaimei Yuan, Yubo Qing, Honghui Li, Kaixiang Xu, Wanyun Zhu, Heng Zhao, Baoyu Jia, Weirong Pan, Jianxiong Guo, Xuezeng Zhang, Wenmin Cheng, Wei Wang, Hong-Ye Zhao, Hong-Jiang Wei
Pig-to-human organ transplantation has drawn attention in recent years due to the potential use of pigs as an alternative source of human donor organs. While GGTA1 knockout (GTKO) can protect xenografts from hyperacute rejection, complement-dependent cytotoxicity might still contribute to this type of rejection. To prolong the xenograft survival, we utilized a T2A-mediated pCMV-hCD55-T2A-hCD59-Neo vector and transfected the plasmid into GTKO Diannan miniature pig fetal fibroblasts. After G418 selection combined with single-cell cloning culture, four colonies were obtained, and three of these were successfully transfected with the hCD55 and hCD59...
June 18, 2018: Molecular Biotechnology
F Oesch, E Fabian, Robert Landsiedel
Studies on the metabolic fate of medical drugs, skin care products, cosmetics and other chemicals intentionally or accidently applied to the human skin have become increasingly important in order to ascertain pharmacological effectiveness and to avoid toxicities. The use of freshly excised human skin for experimental investigations meets with ethical and practical limitations. Hence information on xenobiotic-metabolizing enzymes (XME) in the experimental systems available for pertinent studies compared with native human skin has become crucial...
June 18, 2018: Archives of Toxicology
Felix Berlth, Han-Kwang Yang
Minimal-invasive gastrectomy has been established as commonly used method for the early gastric cancer in Korea and Japan. From the first laparoscopic cancer gastrectomy in 1992 in Japan, numerous prospective randomized trials from these two countries have gained the evidence for non-inferiority or even specific benefits compared to open surgery. In Korea, the "Korean Laparoscopic Gastrointestinal Surgical Study Group" (KLASS group) founded, in 2004, successfully gained evidence not only in regards of oncological safety of laparoscopic gastrectomy, but also for the impact of different reconstruction methods and alternative extents of luminal resection on postoperative outcome and quality of life...
June 18, 2018: Updates in Surgery
Young Suk Park, Dong Joon Shin, Sang-Yong Son, Ki-Hyun Kim, Dong Jin Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
BACKGROUND: Uncut Roux-en-Y gastrojejunostomy (uRYGJ) was developed to prevent slow peristalsis in the Roux limb after Roux-en-Y gastrojejunostomy (RYGJ). This study compared the incidence of Roux stasis syndrome (RSS) and severe gastric food stasis in gastric cancer patients who underwent RYGJ or uRYGJ after laparoscopic curative distal gastrectomy. METHODS: Between January 2006 and June 2012, 319 patients underwent RYGJ or uRYGJ. After covariates were adjusted by propensity score matching, 39 patients in the RYGJ group and 65 patients in the uRYGJ group were included in the final analysis...
June 18, 2018: World Journal of Surgery
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